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Current Problems in Pediatric and Adolescent Health Care最新文献

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Emerging therapeutics in the management of food allergy 治疗食物过敏的新疗法。
IF 3 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01 DOI: 10.1016/j.cppeds.2025.101732
Noor Hamideh , Lydia Su Yin Wong
Food allergy therapy has experienced rapid growth over the past five years. In addition to avoidance measures and reactive treatment of accidental exposures, physicians can now offer patients multiple therapies for reducing the risk of severe reactions upon accidental exposure, and potentially achieving sustained remission. Many promising therapies are also in the pipeline.
In this review, we outline the clinical management of food allergy, including mainstream non-pharmaceutical therapies, such as food oral immunotherapy (OIT), as well as three FDA-approved therapies: Palforzia (pharmaceutical peanut oral immunotherapy), omalizumab (anti-IgE monoclonal antibody), and Neffy (intranasal epinephrine).
We also discuss emerging therapies, including novel routes of immunotherapy administration (epicutaneous, subcutaneous, sublingual, oral mucosal) and existing immunomodulatory therapies undergoing trials for use in food allergy, including dupilumab (anti-IL-4 and IL-13 monoclonal antibody), abrocitinib (oral JAK inhibitor) and abatacept (IgG-CTLA-4 fusion protein).
食物过敏治疗在过去五年中经历了快速发展。除了避免意外暴露的措施和反应性治疗外，医生现在可以为患者提供多种治疗方法，以减少意外暴露后严重反应的风险，并有可能实现持续缓解。许多有前景的疗法也在研发中。在这篇综述中，我们概述了食物过敏的临床管理，包括主流的非药物治疗，如食品口服免疫治疗（OIT），以及fda批准的三种治疗方法：Palforzia（药物花生口服免疫治疗），omalizumab（抗ige单克隆抗体）和Neffy（鼻内肾上腺素）。我们还讨论了新兴的治疗方法，包括新的免疫治疗给药途径（表皮、皮下、舌下、口腔粘膜）和现有的用于食物过敏的免疫调节疗法，包括杜匹单抗（抗il -4和IL-13单克隆抗体）、阿布替尼（口服JAK抑制剂）和阿巴接受（IgG-CTLA-4融合蛋白）。
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引用次数: 0
Approach to the spectrum of infant non-IgE-mediated food allergy manifestations and physiologic infant behaviors 婴儿非ige介导的食物过敏表现和婴儿生理性行为谱的探讨。
IF 3 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01 DOI: 10.1016/j.cppeds.2025.101730
Katherine Herman, Kirsi M. Järvinen
Physiologic infant behaviors and symptoms of pathologic conditions such as gastroesophageal reflux disease, IgE-mediated food allergy, eosinophilic esophagitis, and other non-IgE-mediated food allergy (including food protein-induced allergic proctocolitis, acute and chronic forms of food protein-induced enterocolitis syndrome, and food protein-induced enteropathy) may have significant overlap, leading to diagnostic uncertainty for primary care physicians and pediatric subspecialists alike. Here we explore the clinical features of gastroesophageal reflux disease and IgE-mediated and non-IgE-mediated food allergy in infants, highlighting the considerable similarities in symptomology and difficulties in ascertaining an accurate diagnosis. Utilizing case studies, we discuss diagnostic and management pearls and review the ramifications of delayed diagnosis or misdiagnosis of infant food allergy for both infants and their caregivers.
婴儿的生理行为与胃食管反流病、IgE 介导的食物过敏、嗜酸性粒细胞食管炎和其他非 IgE 介导的食物过敏（包括食物蛋白诱导的过敏性直肠结肠炎、急性和慢性食物蛋白诱导的肠炎综合征和食物蛋白诱导的肠病）等病理情况的症状可能有很大的重叠，从而导致初级保健医生和儿科亚专科医生在诊断上的不确定性。在此，我们探讨了婴儿胃食管反流病、IgE 介导的和非 IgE 介导的食物过敏的临床特征，强调了症状学中相当大的相似性以及确定准确诊断的困难。通过病例研究，我们讨论了诊断和管理要点，并回顾了延迟诊断或误诊婴儿食物过敏对婴儿及其看护者的影响。
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引用次数: 0
IF 3.7 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01
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引用次数: 0
IF 3.7 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01
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引用次数: 0
IF 3.7 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01
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引用次数: 0
IF 3.7 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01
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引用次数: 0
IF 3.7 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01
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引用次数: 0
IF 3.7 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01
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引用次数: 0
IF 3.7 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01
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引用次数: 0
IF 3.7 4区 医学 Q1 PEDIATRICS
Current Problems in Pediatric and Adolescent Health Care
Pub Date : 2025-01-01
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引用次数: 0
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