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Unveiling the Allergy-Meniere Connection: Exploring the Impact of Allergen Positivity on Meniere's Disease Severity. 揭开过敏与美尼尔病的联系:探索过敏原阳性对梅尼埃病严重程度的影响。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-02 DOI: 10.1007/s12070-023-04337-5
Kirubakaran Kothandaraman, Satyawati Mohindra, Naresh Kumar Panda, Gyana Ranjan Nayak, Sanjay Munjal

Meniere's Disease is a rare ear disorder that can cause severe morbidity to the patient and has no definitive treatment to date. Endolymphatic hydrops is the critical event. Though symptomatology is well understood, the exact etiology of Endolymphatic hydrops attack is still unclear. Twenty-five consecutive patients of Meniere's Disease diagnosed in the Vertigo clinic aged 12 to 70 years were included. Their allergic status was evaluated using a skin prick test. Allergic and non-allergic patients were then identified. Comparison between the two groups was made to identify the effect of allergy on the severity of symptoms using vertigo scales, Functional level scale, Dizziness handicap index, and Pure tone average staging. The prevalence of allergy among Meniere's Disease patients was 56%. The most common allergen found in our study was tyrophagus(n = 8). Polysensitization was more common(n = 12). Airborne allergens were more common than food allergens. There was no significant relationship between the severity scales and the allergen positivity status (p > 0.05). The prevalence of allergy is more among patients with Meniere's Disease. The Endolymphatic sac is allergy prone. The occurrence of endolymphatic hydrops may be due to a cross-reaction of allergen-induced IgE antibodies to self-antigen. Management of the specific allergen may help decrease symptomatology in these patients. Allergen-specific therapies have a promising role in the treatment of allergic conditions and provide a long-term symptom-free period in affected individuals. This can be applied in patients with Meniere's Disease having associated allergic features based on their skin prick test results.

美尼尔氏病是一种罕见的耳部疾病,可导致患者严重发病,至今仍无确切的治疗方法。内淋巴水肿是关键事件。虽然人们对症状有了很好的了解,但内淋巴水肿发作的确切病因仍不清楚。眩晕门诊连续收治了 25 名梅尼埃病患者,年龄在 12 岁至 70 岁之间。通过皮肤点刺试验评估了他们的过敏状态。然后确定了过敏和非过敏患者。使用眩晕量表、功能水平量表、眩晕障碍指数和纯音平均分期对两组患者进行比较,以确定过敏对症状严重程度的影响。美尼尔病患者的过敏症发病率为 56%。在我们的研究中发现,最常见的过敏原是酪胺菌(8 例)。多过敏原更为常见(12 例)。空气传播的过敏原比食物过敏原更常见。严重程度量表与过敏原阳性状态之间没有明显关系(P > 0.05)。美尼尔氏病患者的过敏症发病率较高。内淋巴囊容易引起过敏。内淋巴水肿的发生可能是由于过敏原诱导的 IgE 抗体与自身抗原发生交叉反应。对特定过敏原进行处理可能有助于减轻这些患者的症状。过敏原特异性疗法在治疗过敏性疾病方面大有可为,可使患者长期无症状。根据皮肤点刺试验结果,这种疗法可用于具有相关过敏特征的美尼尔氏病患者。
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引用次数: 0
Implementation of the Symptom Based Risk Calculator for Head and Neck Cancer HaNC-RC v.2 Post COVID-19 Pandemic. A Single Centre Audit. COVID-19 大流行后基于症状的头颈癌风险计算器 HaNC-RC v.2 的实施情况。单中心审计。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-04 DOI: 10.1007/s12070-023-04412-x
Adam Hatoum, Radhika Kumta, Selda Boztepe, Amr Salem, Jagdeep Virk

Background: As the incidence of head and neck cancer continues to rise, the volume of referrals to our urgent suspected cancer clinics continues to rise with it. Cancer referral and review time targets are not being met within the UK, and our centre has experienced an increase in volume of referrals which cannot be met by available clinic slots. We proposed a pathway to the North East London Cancer Alliance to safely triage these patients using the Head and Neck Cancer Risk Calculator version 2 (HaNC-RCv2).

Methods: All 2-week-wait referrals to our unit in June 2023 were initially triaged in a telephone consultation by a specialty registrar working in the department. A brief history would be taken, and a risk score calculated. Those scoring < 5% were moved to routine or less urgent follow up.

Results: 120 patients were referred to our department. We were able to safely triage 48.7% patients off the urgent suspected cancer pathway and to routine follow up. A total of 3 patients were found to have a head and neck malignancy and all were treated within the 62 day window.

Conclusion: As trusts work to cut the waiting times following the COVID-19 pandemic, there is an evident need for more efficient practices. The use of validated, safe triaging methods such as this can play a central role.

背景:随着头颈部癌症发病率的不断上升,我们的疑似癌症紧急门诊的转诊量也随之增加。在英国,癌症转诊和复查时间的目标没有实现,我们中心的转诊量也随之增加,而现有的门诊时间无法满足这些需求。我们向伦敦东北部癌症联盟(North East London Cancer Alliance)提出了一条途径,利用头颈癌风险计算器第二版(HaNC-RCv2)对这些患者进行安全分流:所有在 2023 年 6 月转诊到我们科室的两周等待期患者最初都将由在科室工作的专科注册医师通过电话咨询进行分流。他们将简要询问病史并计算风险评分。这些评分结果:120 名患者被转诊到我们科室。我们能够安全地将 48.7% 的患者从紧急疑似癌症路径中分流出来,并进行常规随访。共有 3 名患者被发现患有头颈部恶性肿瘤,所有患者均在 62 天内接受了治疗:结论:COVID-19 大流行后,各信托机构都在努力缩短候诊时间,因此显然有必要采取更有效的做法。使用这种经过验证的安全分诊方法可以发挥核心作用。
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引用次数: 0
Total Thyroidectomy while on Extracorporeal Membrane Oxygenation for Thyroid Storm. 在体外膜氧合治疗甲状腺风暴的同时进行全甲状腺切除术。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-27 DOI: 10.1007/s12070-023-04430-9
Jia Jia Wee, Kai Jun Tay, Siti Radhziah Binte Sudirman, Shaun Ray Han Loh

Thyroid storm is an acute life-threatening condition of hyperthyroidism that can present with cardiac failure, requiring extracorporeal membrane oxygenation (ECMO). We present the first case reported of total thyroidectomy successfully performed while on ECMO for thyroid storm in a 32-year-old male. This case highlights the challenges of managing refractory thyroid storm with multi-organ failure. We demonstrate that total thyroidectomy may still be safely performed while on ECMO for thyroid storm, if steps are taken to optimise the patient perioperatively, with careful surgical and anaesthesia planning.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04430-9.

甲状腺风暴是一种危及生命的急性甲状腺功能亢进症,可伴有心力衰竭,需要进行体外膜肺氧合(ECMO)。我们介绍了首例因甲状腺风暴而在使用 ECMO 时成功实施甲状腺全切除术的病例,患者是一名 32 岁的男性。该病例凸显了治疗难治性甲状腺风暴合并多器官功能衰竭所面临的挑战。我们证明,如果采取步骤优化患者围手术期,并制定周密的手术和麻醉计划,在使用ECMO治疗甲状腺风暴时仍可安全地实施全甲状腺切除术:在线版本包含补充材料,可在 10.1007/s12070-023-04430-9上查阅。
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引用次数: 0
Endoscopic Retrieval of a Penetrating Ethmoid Sinus Foreign Body with a Successful Minimally Invasive Approach: A Case Report. 以微创方法成功取出穿透性乙状窦异物的内窥镜手术:病例报告。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-27 DOI: 10.1007/s12070-023-04447-0
Lekha Kawal Kapoor

A 14-year-old girl suffered a rare injury when a pen pierced her left eye, leading to a foreign object lodged in her ethmoid sinus. Prompt diagnosis and endoscopic sinus surgery (ESS) effectively removed the object, highlighting ESS as a valuable approach for managing uncommon sinus foreign bodies while minimizing complications.

一名 14 岁女孩因被钢笔刺伤左眼,导致异物卡在乙状窦内而遭受罕见伤害。及时的诊断和内窥镜鼻窦手术(ESS)有效地取出了异物,凸显了ESS是处理不常见鼻窦异物的重要方法,同时将并发症降至最低。
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引用次数: 0
Outcome of Adjuvant Radiotherapy and Adjuvant Chemoradiation for Oral Cancers with Close Margins of Resection. 切除边缘较近的口腔癌辅助放疗和辅助化疗的效果
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-27 DOI: 10.1007/s12070-023-04416-7
Lini Joseph, S M Azeem Mohiyuddin, G N Manjunath, R Kalyani

Oral cancers comprise 50% of all head and neck malignancies in India which can be attributed to tobacco chewing. Advanced oral cancers are managed with surgery followed by adjuvant radiotherapy or adjuvant chemoradiation. There is paucity of studies regarding need for adjuvant treatment in oral cancers with close margins i.e. ≤ 0.5 cm after formalin fixation. This study aims at documenting the oncological outcome with regards to loco-regional control, disease-free survival, overall survival and complications of adjuvant radiotherapy and adjuvant chemoradiation in operated oral cancer patients having close margins of resection. In this Retrospective cohort study, 163 patients with stage T1-T4 oral cancers operated between 2015 and 2019 who have fulfilled the inclusion and exclusion criteria, received adjuvant treatment and could be followed up for at least one year were included. At the end of 45 months, the overall survival was 74.7% and disease specific survival was 82.7%. Among the 7 patients who defaulted radiotherapy, 4 patients succumbed to the disease. Complications were bone marrow depression (2 patients), dysphagia (17) and Trismus (1). Adjuvant radiotherapy should be given in oral cancer patients with close margins of resection since it improves the oncological outcome and disease specific survival and the benefit often outweighs the risk.

在印度,口腔癌占所有头颈部恶性肿瘤的 50%,这可能与咀嚼烟草有关。晚期口腔癌可通过手术治疗,然后进行辅助放疗或辅助化疗。关于边缘较近的口腔癌(即福尔马林固定后≤ 0.5 厘米)是否需要辅助治疗的研究很少。本研究旨在记录切除边缘较近的口腔癌患者接受辅助放疗和辅助化疗后的局部区域控制、无病生存期、总生存期和并发症等方面的肿瘤学结果。在这项回顾性队列研究中,纳入了163名2015年至2019年期间手术的T1-T4期口腔癌患者,这些患者均符合纳入和排除标准,接受了辅助治疗,并可随访至少一年。45个月后,总生存率为74.7%,疾病特异性生存率为82.7%。在7名放弃放疗的患者中,有4人死于疾病。并发症包括骨髓抑制(2 例)、吞咽困难(17 例)和肢体瘫痪(1 例)。对于切除边缘较近的口腔癌患者,应给予辅助放射治疗,因为它能改善肿瘤预后和疾病特异性生存率,而且收益往往大于风险。
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引用次数: 0
Posterior Belly of Digastric Muscle is not Always an Intern's Friend, During Neck Dissection. 在颈部解剖过程中,消化肌后腹部并不总是实习生的朋友。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-07 DOI: 10.1007/s12070-023-04359-z
Jeyashanth Riju, Prankur Verma

Among the various anatomical landmarks during neck dissection, digastric muscle is one of the most important. It is well known that all important blood vessels in neck lies deep to digastric. Thus, it acts as a safety landmark during neck dissection. In this article we describe a variation in vascular anatomy with relation to posterior belly of digastric that has not been reported so far during live surgery. Surgeon performing neck dissection should have a detailed knowledge of anatomy and infrequent anatomical variation. The knowledge of current anatomical variation will avoid torrential bleed during neck dissection and preserve the artery for vascular related procedures.

在颈部解剖的各种解剖标志中,腹股沟肌是最重要的标志之一。众所周知,颈部所有重要的血管都位于腹股沟的深处。因此,它是颈部解剖过程中的安全地标。在本文中,我们描述了与腹股沟后腹部有关的血管解剖变异,这是迄今为止在现场手术中从未报道过的。进行颈部解剖的外科医生应详细了解解剖结构和不常见的解剖变异。对当前解剖变异的了解将避免在颈部解剖时发生大出血,并为血管相关手术保留动脉。
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引用次数: 0
Prevalence of Vocal Fatigue Due to the Use of Facial Protective Gear in Teaching Medical Professionals. 教学医务人员因使用面部防护装备而发声疲劳的普遍程度。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-08 DOI: 10.1007/s12070-023-04350-8
Shreya A Bhat, Suja Sreedharan, Radish Kumar Balasubramanium, K V Apoorva

Since the COVID-19 pandemic, masks have become far more widely used by doctors and are now commonplace in the hospital, with many professionals still wearing them for extended amounts of time. Emerging literature describing numerous mask-related difficulties prompted the authors to conduct a study aimed at assessing the self-perceived impact on voices of teaching doctors due to facial protective gear. In this study carried out from October 2021 to March 2022, data was gathered from 170 pre-, para-, and clinical professionals who were involved in offline teaching. Over half of teaching medical professionals were found to be vocally fatigued. Pre and para-clinical professionals have greater vocal tiredness and avoidance than clinical doctors (p = 0.016). The type of mask used does not make a significant difference in degree of vocal fatigue. Individuals with lingering respiratory difficulties following COVID-19 were significantly more vocally fatigued than their recovered peers (p value for tiredness and avoidance = 0.010). Thus, teaching doctors are at risk of impaired quality of life due to vocal fatigue. Further research on vocal habits and rest practices in the study population may help identify the most effective interventions.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04350-8.

自 COVID-19 大流行以来,口罩在医生中的使用越来越广泛,目前在医院中已司空见惯,但许多专业人员仍长时间佩戴口罩。新出现的文献描述了许多与口罩相关的困难,这促使作者开展了一项研究,旨在评估教学医生自我感觉到的面部防护装备对嗓音的影响。这项研究于 2021 年 10 月至 2022 年 3 月进行,收集了 170 名参与线下教学的学前、准临床和临床专业人员的数据。研究发现,超过一半的医学专业教学人员存在声音疲劳。与临床医生相比,预、准临床专业人员的声音疲劳和回避程度更高(p = 0.016)。使用的口罩类型对发声疲劳程度的影响不大。COVID-19 后呼吸困难挥之不去者的发声疲劳程度明显高于康复者(疲劳和回避的 p 值 = 0.010)。因此,教学医生有可能因发声疲劳而导致生活质量下降。对研究人群发声习惯和休息方式的进一步研究可能有助于确定最有效的干预措施:在线版本包含补充材料,可在 10.1007/s12070-023-04350-8。
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引用次数: 0
Audiological Evaluation of Leprosy Patients in an Endemic Area of Central India: A Case-Control Pilot Study. 印度中部麻风病流行区麻风病人的听力评估:病例对照试点研究。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-04 DOI: 10.1007/s12070-023-04381-1
Yashpriya Nayak, Neel Prabha, Ripu Daman Arora, Monalisa Jati, Aakash Aggarwal

There are discrepancies in the literature about the specific influence of leprosy on auditory functions. In routine clinical practice regular hearing screening of leprosy patients is not done. Due to conflicting reports of auditory system involvement in the literature, we conducted this case control study to evaluate the need of regular hearing screening in leprosy patients. A complete otological examination of thirty leprosy patients was conducted. Thirty age and sex matched healthy individual attending ear, nose and throat outpatient department were enrolled as control. Ten cases (33.3%) out of the thirty leprosy patients were found to have high frequency (4 and 8 kHZ) sensorineural hearing loss. The results of this study suggest that leprosy patients require routine monitoring for auditory functions for early identifications of sensorineural hearing loss. As our study is a case-control study with small sample size, in future large prospective studies are required to evaluate the correlation of hearing loss with leprosy and to see the progression hearing loss.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04381-1.

关于麻风病对听觉功能的具体影响,文献中说法不一。在常规临床实践中,并没有对麻风病人进行定期听力筛查。由于文献中关于听觉系统受影响的报道相互矛盾,我们开展了这项病例对照研究,以评估麻风病人定期进行听力筛查的必要性。我们对 30 名麻风病人进行了全面的耳科检查。30名年龄和性别匹配的健康人在耳鼻喉科门诊就诊,作为对照。结果发现,30 名麻风病人中有 10 例(33.3%)患有高频(4 kHZ 和 8 kHZ)感音神经性听力损失。研究结果表明,麻风病人需要进行常规听觉功能监测,以便及早发现感音神经性听力损失。由于我们的研究是一项样本量较小的病例对照研究,因此今后需要进行大规模的前瞻性研究,以评估听力损失与麻风病的相关性,并观察听力损失的进展情况:在线版本包含补充材料,可在 10.1007/s12070-023-04381-1上查阅。
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引用次数: 0
A Retrospective Study of Correlation between Radiological and Intra-Operative Findings in FESS: A Case Series. 关于 FESS 手术中放射学检查结果与术中检查结果之间相关性的回顾性研究:病例系列。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-02 DOI: 10.1007/s12070-023-04371-3
Fathima Minnu P, Priya K, Balaji D, Ramya Shree C

Introduction: The imaging of the paranasal sinuses has advanced from plain X-ray films to CT and MRI. This advancement in the radiological field helps to yield more accurate information and aids in arriving at a proper differential diagnosis, especially for rhinosinusitis. However, CT should be used cautiously among patients considering its effects due to radiation. Aim: This study aims to correlate the pre-operative radiological findings with the intraoperative functional endoscopic sinus surgery findings in a series of 100 cases. Materials and Methods: A retrospective case series was conducted among 100 cases who had complaints relating to nose and paranasal sinuses in a tertiary care hospital, Chengalpattu. Their symptoms, clinical examination, pre-operative radiological findings, and intra operative findings have been recorded. The collected data was analyzed for correlation and agreement between pre-operative radiological findings and intraoperative findings. Results: Almost all the CT revealed pathologies like polyps, mucosal thickening, and anatomical variations. However, intraoperatively, only 64.5% had mucosal thickening and 23.6% had polyps. Poor to acceptable correlation has been reported among patients with OMC obstruction, polyps, and mucosal thickening, respectively. Yet, no agreement was seen between pre-operative radiological and intraoperative findings. Conclusion: Endoscopy remains the most valuable test to diagnose, confirm the severity and manage sinus related diseases.

介绍:鼻旁窦成像技术已从普通 X 光片发展到 CT 和 MRI。放射学领域的这一进步有助于获得更准确的信息,有助于做出正确的鉴别诊断,尤其是鼻窦炎。不过,考虑到 CT 的辐射影响,患者应谨慎使用 CT。目的:本研究旨在将 100 例系列病例的术前放射学检查结果与术中功能性内窥镜鼻窦手术检查结果进行关联分析。材料与方法:在 Chengalpattu 的一家三级医院对 100 例有鼻部和副鼻窦相关主诉的病例进行了回顾性病例系列研究。记录了他们的症状、临床检查、术前放射学检查结果和术中检查结果。对收集的数据进行了分析,以确定术前放射学检查结果与术中检查结果之间的相关性和一致性。结果:几乎所有的 CT 都显示出息肉、粘膜增厚和解剖变异等病变。然而,术中只有 64.5%的患者有粘膜增厚,23.6%的患者有息肉。有报告称,OMC 梗阻、息肉和粘膜增厚患者之间的相关性从较差到可以接受。然而,术前放射学检查结果与术中检查结果并不一致。结论:内窥镜检查仍然是诊断、确认鼻窦相关疾病的严重程度并进行治疗的最有价值的检查方法。
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引用次数: 0
New Frontiers in Newborn Hearing Screening: Understanding Auditory Neuropathy and its Predictive Trajectory. 新生儿听力筛查的新前沿:了解听觉神经病变及其预测轨迹。
IF 0.6 Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-04 DOI: 10.1007/s12070-023-04386-w
Sanjay Kumar, Sudheer Kumar Marlapudi, Rashmi Natraj

Auditory Neuropathy (AN) poses a substantial challenge in neonatal auditory screenings due to its complex course and potential for delayed onset. Early identification and intervention are important for optimizing developmental outcomes. This study aimed to explore the prevalence, determinants, and temporal progression of AN in neonates, and assess the therapeutic benefit of amplification devices on their communication skills. The study utilized a longitudinal cohort design to analyze a cohort of 200 neonates from a tertiary care center over the duration from January 2021 to December 2022. Auditory evaluations were conducted at specified intervals, utilizing a comprehensive battery of auditory assessments. Statistical analyses, including regression models, were employed to identify associations between various determinants and the progression of AN. The results of the study revealed a significant correlation between low birth weight and familial history with onset of AN. The data also revealed a gradual rise in AN prevalence over the study duration. However, a negative correlation was observed between AN severity and communication skills. The utilization of hearing aids was associated with enhanced communication outcomes. The study highlights the importance of comprehensive auditory screenings in newborns, particularly emphasizing the early detection and intervention of AN. Based on empirical findings, it emerged that amplification devices, particularly hearing aids, have the potential to mitigate the detrimental effects of auditory neuropathy (AN) on communication skills. This study provides a valuable contribution to the academic debate by highlighting the need for strengthening neonatal auditory screening protocols. The findings have profound implications for clinical practices, highlighting the role of early interventions in optimizing developmental prospects for neonates diagnosed with AN.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04386-w.

听觉神经病(AN)病程复杂,且可能延迟发病,这给新生儿听觉筛查带来了巨大挑战。早期识别和干预对于优化发育结果非常重要。本研究旨在探讨新生儿听觉障碍的发病率、决定因素和时间进展,并评估扩音设备对新生儿沟通能力的治疗效果。该研究采用纵向队列设计,分析了一家三级医疗中心在2021年1月至2022年12月期间的200名新生儿队列。在规定的时间间隔内,利用听觉评估综合电池进行听觉评估。研究采用了包括回归模型在内的统计分析方法,以确定各种决定因素与新生儿听觉障碍进展之间的关联。研究结果表明,低出生体重和家族史与自闭症发病之间存在显著相关性。数据还显示,在研究期间,自闭症的发病率逐渐上升。然而,AN 的严重程度与沟通能力之间呈负相关。助听器的使用与沟通能力的提高有关。这项研究强调了对新生儿进行全面听力筛查的重要性,尤其是强调了早期发现和干预听力障碍的重要性。根据实证研究结果,扩音设备,尤其是助听器,有可能减轻听觉神经病变(AN)对沟通能力的不利影响。本研究强调了加强新生儿听觉筛查方案的必要性,为学术讨论做出了宝贵贡献。研究结果对临床实践具有深远影响,强调了早期干预在优化被诊断患有听觉神经病的新生儿发展前景方面的作用:在线版本包含补充材料,可在 10.1007/s12070-023-04386-w.上查阅。
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引用次数: 0
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Indian Journal of Otolaryngology and Head and Neck Surgery
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