Pub Date : 2024-10-01Epub Date: 2024-05-31DOI: 10.1007/s12070-024-04775-9
Raman Sharma, Pratik Kumar, Divya Singh, Ravi Meher, Jyoti Kumar
Carotidynia is transient perivascular inflammation of the carotid artery. It is a rare condition of head and neck associated with atypical neck pain, often unilateral. Patients with carotidynia often presents with atypical symptoms that makes the diagnosis of this rare entity difficult. In this article, we report a case series of 3 patients that presents with variable symptoms along with different investigative modalities and treatment approaches. Due to rare entity, this condition is often misdiagnosed or necessitates several visits to various specialties before a diagnosis is reached. Thorough clinical examination along with radiology is must to reach to a diagnosis. Patient should be counselled regarding the benign nature of the disease that can be easily controlled by low dose steroids.
{"title":"Carotidynia - An Unexplored Entity in Otolaryngology Practice: Three Case Reports & Review of Literature.","authors":"Raman Sharma, Pratik Kumar, Divya Singh, Ravi Meher, Jyoti Kumar","doi":"10.1007/s12070-024-04775-9","DOIUrl":"https://doi.org/10.1007/s12070-024-04775-9","url":null,"abstract":"<p><p>Carotidynia is transient perivascular inflammation of the carotid artery. It is a rare condition of head and neck associated with atypical neck pain, often unilateral. Patients with carotidynia often presents with atypical symptoms that makes the diagnosis of this rare entity difficult. In this article, we report a case series of 3 patients that presents with variable symptoms along with different investigative modalities and treatment approaches. Due to rare entity, this condition is often misdiagnosed or necessitates several visits to various specialties before a diagnosis is reached. Thorough clinical examination along with radiology is must to reach to a diagnosis. Patient should be counselled regarding the benign nature of the disease that can be easily controlled by low dose steroids.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The major prognostic factor in head-neck squamous cell carcinoma is the status of lymph nodes. Though there are studies addressing the role of neck dissection in organ preservation protocol, a lacuna still exists as far as the question of upfront neck dissection arises. Despite the potential benefits of upfront neck dissection; the benefits have not been well researched and thus its place in management of head-neck cancers undergoing organ preservation protocol is still questionable. We conducted an observational study in 22 patients with T1 - 2N2 - 3a biopsy proven squamous cell carcinoma of hypopharynx, oropharynx and laryngopharynx which were eligible for organ preservation protocol for their primary site. The primary outcome was to calculate their overall survival rate at 5 years. Overall 5 year survival rate was 68.12%, 5-year Disease free survival rate was 77.2%. The time to start for the primary site, after neck dissection however had a significant effect on overall survival. Those who had a delay of 21 days or less had 80.1% survival at 5 years compared to those who started at 30 days (61.3%) and drastically reduced in those who started at 39 days (20.4%). Log-rank test for the effect of nodal status showed a significant difference in terms of 5 year survival between the groups(p = .027). The 5 year survival rates for N2A, N3A and N2B nodal status were 88.8%, 50% ,and 54.5% ,respectively. We strongly favour upfront neck dissections in a subset of head-neck squamous cell carcinoma cases with T1 - 2N2 - 3a eligible for organ preservation regimen.
{"title":"Upfront Neck Dissection in Organ Preservation Protocol in Head-Neck SCC : Can it be a Game Changer?","authors":"Bhanu Bhardwaj, Jaskaran Singh, Harmanjot Singh Kalra, Sohail Thapar, Dhanwant Aulakh","doi":"10.1007/s12070-024-04793-7","DOIUrl":"https://doi.org/10.1007/s12070-024-04793-7","url":null,"abstract":"<p><p>The major prognostic factor in head-neck squamous cell carcinoma is the status of lymph nodes. Though there are studies addressing the role of neck dissection in organ preservation protocol, a lacuna still exists as far as the question of upfront neck dissection arises. Despite the potential benefits of upfront neck dissection; the benefits have not been well researched and thus its place in management of head-neck cancers undergoing organ preservation protocol is still questionable. We conducted an observational study in 22 patients with T<sub>1 - 2</sub>N<sub>2 - 3a</sub> biopsy proven squamous cell carcinoma of hypopharynx, oropharynx and laryngopharynx which were eligible for organ preservation protocol for their primary site. The primary outcome was to calculate their overall survival rate at 5 years. Overall 5 year survival rate was 68.12%, 5-year Disease free survival rate was 77.2<b>%.</b> The time to start for the primary site, after neck dissection however had a significant effect on overall survival. Those who had a delay of 21 days or less had 80.1% survival at 5 years compared to those who started at 30 days (61.3%) and drastically reduced in those who started at 39 days (20.4%). Log-rank test for the effect of nodal status showed a significant difference in terms of 5 year survival between the groups(<i>p</i> = .027). The 5 year survival rates for N2A, N3A and N2B nodal status were 88.8%, 50% ,and 54.5% ,respectively. We strongly favour upfront neck dissections in a subset of head-neck squamous cell carcinoma cases with T<sub>1 - 2</sub>N<sub>2 - 3a</sub> eligible for organ preservation regimen.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-05-31DOI: 10.1007/s12070-024-04762-0
Nader G Zalaquett, Nadim Hamadeh, Rolvix H Patterson, Eric K Kim, Zeina Korban, Mark G Shrime
Study background and aims: There are marked barriers to research and publishing for low- and middle- income country (LMIC) ENT researchers. This could be reflected in LMIC journal characteristics and research, which has never been investigated. We aim to characterize differences in the number, geographic distribution, publishing costs, reach, number of articles, citations, and impact factors of high-income country (HIC) journals compared to LMIC journals.
Methods: We included journals listed under the category "Otorhinolaryngology' in three major journal databases. From journal websites, we collected data related to financial model, waiver policy, access, and distribution. Additionally, from the Clarivate Journal Citation Reports 2022, we collected the following journal metrics: total articles, total citations, journal citation indicator, journal impact factor (JIF), 5-year JIF, and JIF without self cites.
Results: 79.7% HIC journals offered English editing services, compared with 25.0% of LMIC journals. Additionally, 40.0% of HIC journals are solely open access compared with 92.0% in LMICs. Lower journal metrics were seen in LMIC journals, including 2022 mean total articles (107 HICs vs. 60 LMICs), total citations (4296 vs. 751), journal citation indicator (0.88 vs. 0.35), and journal impact factor (12.68 vs. 0.82).
Conclusion: We have identified substantial differences in the distribution, English editing services, and journal metrics of HIC journals compared to LMIC journals. These may point to potential barriers to publishing and research access for those in LMICs. To support LMIC research, future work should evaluate opportunities to increase the number of ENT journals in LMICs, expand open access publishing, improve access to language services, and increase LMIC research impact.
研究背景和目的:中低收入国家(LMIC)的耳鼻喉科研究人员在研究和出版方面存在明显障碍。这可能反映在中低收入国家的期刊特点和研究中,而这方面的研究还从未有过。我们旨在描述高收入国家(HIC)期刊与中低收入国家(LMIC)期刊在数量、地理分布、出版成本、影响力、文章数量、引用率和影响因子方面的差异:我们收录了三大期刊数据库中 "耳鼻喉科 "类别下的期刊。我们从期刊网站上收集了与财务模式、豁免政策、访问和发行相关的数据。此外,我们还从 Clarivate Journal Citation Reports 2022 中收集了以下期刊指标:总文章数、总引用数、期刊引用指标、期刊影响因子(JIF)、5 年 JIF 和不含自引的 JIF:79.7%的高收入国家期刊提供英文编辑服务,而低收入国家期刊的这一比例为25.0%。此外,40.0% 的高收入国家和地区期刊完全开放获取,而低收入国家和地区的这一比例为 92.0%。低收入与中等收入国家的期刊指标较低,包括2022篇平均总文章数(107篇高收入与中等收入国家 vs. 60篇低收入与中等收入国家)、总被引次数(4296次 vs. 751次)、期刊被引指标(0.88 vs. 0.35)和期刊影响因子(12.68 vs. 0.82):我们发现高收入国家期刊与低收入国家期刊在发行、英文编辑服务和期刊指标方面存在巨大差异。这些差异可能会给低收入和中等收入国家的出版和研究人员带来潜在的障碍。为支持低收入与中等收入国家的研究,未来的工作应评估增加低收入与中等收入国家耳鼻喉科期刊数量、扩大开放出版、改善语言服务以及提高低收入与中等收入国家研究影响力的机会。
{"title":"A Comparative Analysis of Otolaryngology Journal Characteristics and Metrics Across World Bank Income Groups.","authors":"Nader G Zalaquett, Nadim Hamadeh, Rolvix H Patterson, Eric K Kim, Zeina Korban, Mark G Shrime","doi":"10.1007/s12070-024-04762-0","DOIUrl":"https://doi.org/10.1007/s12070-024-04762-0","url":null,"abstract":"<p><strong>Study background and aims: </strong>There are marked barriers to research and publishing for low- and middle- income country (LMIC) ENT researchers. This could be reflected in LMIC journal characteristics and research, which has never been investigated. We aim to characterize differences in the number, geographic distribution, publishing costs, reach, number of articles, citations, and impact factors of high-income country (HIC) journals compared to LMIC journals.</p><p><strong>Methods: </strong>We included journals listed under the category \"Otorhinolaryngology' in three major journal databases. From journal websites, we collected data related to financial model, waiver policy, access, and distribution. Additionally, from the Clarivate Journal Citation Reports 2022, we collected the following journal metrics: total articles, total citations, journal citation indicator, journal impact factor (JIF), 5-year JIF, and JIF without self cites.</p><p><strong>Results: </strong>79.7% HIC journals offered English editing services, compared with 25.0% of LMIC journals. Additionally, 40.0% of HIC journals are solely open access compared with 92.0% in LMICs. Lower journal metrics were seen in LMIC journals, including 2022 mean total articles (107 HICs vs. 60 LMICs), total citations (4296 vs. 751), journal citation indicator (0.88 vs. 0.35), and journal impact factor (12.68 vs. 0.82).</p><p><strong>Conclusion: </strong>We have identified substantial differences in the distribution, English editing services, and journal metrics of HIC journals compared to LMIC journals. These may point to potential barriers to publishing and research access for those in LMICs. To support LMIC research, future work should evaluate opportunities to increase the number of ENT journals in LMICs, expand open access publishing, improve access to language services, and increase LMIC research impact.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-05-31DOI: 10.1007/s12070-024-04764-y
Anupam Golash, Tamasuk Das, Abhijit Golash
Introduction: Free tissue transfer is now done routinely for Head & neck reconstruction. A suction drain is needed for efficient drainage of the neck post-dissection & with it arises a new dilemma, challenge or obsession amidst the practicing surgeons about the safe and efficient placement of suction drain in an anatomical location so that it does not injure or impair the anastomosis but will still be able to carry out its role efficiently. No prior studies are available regarding the safe practice. Hence the aim of our study was to explore & establish a reliable manoeuvre where the drain could be introduced in a safe and efficient way. From April of 2017-February of 2024 a prospective study was carried out in which cases of 517 patients were taken into account who underwent head and neck reconstruction using a free tissue transfer procedure where the suction drain tube was placed in the dependent part of the neck (i.e. the posterior triangle region) & the margin of sternocleidomastoid muscle was fixed with the pre-vertebral layer of the cervical fascia. The drain was secured externally with a percutaneous non- absorbable suture.
Study design: A prospective Study.
Study period: April 2017- February 2024.
Observation: A thorough observation was carried out & no evidence of drain induced anastomotic complications were reported.
Conclusion: Hence it can be assumed that this particular method of drain placement is both safe & efficient and it can act as a beacon among the surgeons who suffer a from a dilemma & challenge about where to place the drain safely & efficiently.
{"title":"A Safe Methodology for Suction Drain Placement in in Head & Neck Reconstruction after Free Tissue Transfer.","authors":"Anupam Golash, Tamasuk Das, Abhijit Golash","doi":"10.1007/s12070-024-04764-y","DOIUrl":"https://doi.org/10.1007/s12070-024-04764-y","url":null,"abstract":"<p><strong>Introduction: </strong>Free tissue transfer is now done routinely for Head & neck reconstruction. A suction drain is needed for efficient drainage of the neck post-dissection & with it arises a new dilemma, challenge or obsession amidst the practicing surgeons about the safe and efficient placement of suction drain in an anatomical location so that it does not injure or impair the anastomosis but will still be able to carry out its role efficiently. No prior studies are available regarding the safe practice. Hence the aim of our study was to explore & establish a reliable manoeuvre where the drain could be introduced in a safe and efficient way. From April of 2017-February of 2024 a prospective study was carried out in which cases of 517 patients were taken into account who underwent head and neck reconstruction using a free tissue transfer procedure where the suction drain tube was placed in the dependent part of the neck (i.e. the posterior triangle region) & the margin of sternocleidomastoid muscle was fixed with the pre-vertebral layer of the cervical fascia. The drain was secured externally with a percutaneous non- absorbable suture.</p><p><strong>Study design: </strong>A prospective Study.</p><p><strong>Study period: </strong>April 2017- February 2024.</p><p><strong>Observation: </strong>A thorough observation was carried out & no evidence of drain induced anastomotic complications were reported.</p><p><strong>Conclusion: </strong>Hence it can be assumed that this particular method of drain placement is both safe & efficient and it can act as a beacon among the surgeons who suffer a from a dilemma & challenge about where to place the drain safely & efficiently.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-05-27DOI: 10.1007/s12070-024-04740-6
Syed Ahmed Shahzaeem Hussain, Hassan Ali, Syed Muzahir Hussain, Syeda Anum Fatima Naqvi, Syed Ahmed Shahzain Hussain, Muhammad Abdullah
Extra Nasopharyngeal Angiofibromas are rare benign vascular tumors typically affecting adolescent males. They have variable sites of origin. Only five cases of extra nasopharyngeal angiofibroma originating from the middle turbinate have been reported in the literature, here we present the sixth such case. A 44-year-old female presented with a history of left-sided nasal obstruction and spontaneous, profuse and recurrent epistaxis. A contrast-enhanced computed tomography (CT) scan showed a hyper vascular mass arising from the left middle turbinate. A provisional diagnosis of extra nasopharyngeal angiofibroma was made and it was successfully surgically excised using a midfacial degloving approach under general anaesthesia. The diagnosis was confirmed with post-operative histopathological analysis. Due to the extremely rare occurrence of Extra Nasopharyngeal Angiofibromas originating from the middle turbinate and their infrequent presentation in female patients, misdiagnosis poses a greater risk of complications. The surgeon must exercise caution before conducting misguided biopsies, which are contraindicated.
Supplementary information: The online version contains supplementary material available at 10.1007/s12070-024-04740-6.
{"title":"Middle Turbinate Angiofibroma in a Middle-Aged Female: A Case Report and Review of the Literature.","authors":"Syed Ahmed Shahzaeem Hussain, Hassan Ali, Syed Muzahir Hussain, Syeda Anum Fatima Naqvi, Syed Ahmed Shahzain Hussain, Muhammad Abdullah","doi":"10.1007/s12070-024-04740-6","DOIUrl":"https://doi.org/10.1007/s12070-024-04740-6","url":null,"abstract":"<p><p>Extra Nasopharyngeal Angiofibromas are rare benign vascular tumors typically affecting adolescent males. They have variable sites of origin. Only five cases of extra nasopharyngeal angiofibroma originating from the middle turbinate have been reported in the literature, here we present the sixth such case. A 44-year-old female presented with a history of left-sided nasal obstruction and spontaneous, profuse and recurrent epistaxis. A contrast-enhanced computed tomography (CT) scan showed a hyper vascular mass arising from the left middle turbinate. A provisional diagnosis of extra nasopharyngeal angiofibroma was made and it was successfully surgically excised using a midfacial degloving approach under general anaesthesia. The diagnosis was confirmed with post-operative histopathological analysis. Due to the extremely rare occurrence of Extra Nasopharyngeal Angiofibromas originating from the middle turbinate and their infrequent presentation in female patients, misdiagnosis poses a greater risk of complications. The surgeon must exercise caution before conducting misguided biopsies, which are contraindicated.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12070-024-04740-6.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-06-28DOI: 10.1007/s12070-024-04751-3
N Aishwarya, G Selvarajan, Kala Samaya
PPPD is a chronic and functional disorder without diagnostic data and definitive laboratory tests. In such conditions, questionnaires are the easiest quantifiable measures to identify and rate the severity of individuals suffering from PPPD. The current study aimed to adapt the Niigata PPPD Questionnaire (NPQ) into Tamil language and analyze its psychometric properties. A conventional method of translation involving forward and backward translation was carried out, followed by subsequent content validation. The translated version was field tested in three groups, the controls, the dizzy group, and PPPD group, for further analysis. The final Tamil version of the questionnaire, NPQ-T, had good reliability and validity. This version was identified to have good sensitivity and specificity in discriminating the PPPD group from the dizzy group. The NPQ in Tamil (NPQ-T) is a valid tool for identifying individuals with PPPD and noting the severity of the exacerbating factors.
{"title":"Translation and Validation of the Niigata PPPD Questionnaire into Tamil: A Tool to Assess Persistent Postural-Perceptual Dizziness.","authors":"N Aishwarya, G Selvarajan, Kala Samaya","doi":"10.1007/s12070-024-04751-3","DOIUrl":"https://doi.org/10.1007/s12070-024-04751-3","url":null,"abstract":"<p><p>PPPD is a chronic and functional disorder without diagnostic data and definitive laboratory tests. In such conditions, questionnaires are the easiest quantifiable measures to identify and rate the severity of individuals suffering from PPPD. The current study aimed to adapt the Niigata PPPD Questionnaire (NPQ) into Tamil language and analyze its psychometric properties. A conventional method of translation involving forward and backward translation was carried out, followed by subsequent content validation. The translated version was field tested in three groups, the controls, the dizzy group, and PPPD group, for further analysis. The final Tamil version of the questionnaire, NPQ-T, had good reliability and validity. This version was identified to have good sensitivity and specificity in discriminating the PPPD group from the dizzy group. The NPQ in Tamil (NPQ-T) is a valid tool for identifying individuals with PPPD and noting the severity of the exacerbating factors.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: the study aimed to characterize the novel entity referred to as secretory carcinoma of the salivary glands.
Methods: we comprehensively evaluated 150 patients afflicted by malignant salivary gland tumors who had been under treatment at the University of Verona. Inclusion criteria primarily focused on the availability of paraffin block materials and adequate follow-up data. Subsequently, we conducted a comprehensive Fluorescent In Situ Hybridization (FISH) analysis, utilizing probes targeting NTRK-3, MALM-2, EWRS-1, HER-2, MDM-2, and NTRK1-2.
Results: out of the initial cohort, 37 patients met the eligibility criteria for our study. We identified NTRK3 gene rearrangements in four patients (11%), two of whom had mucoepidermoid carcinoma, and the remaining two had acinic cell carcinoma. Notably, none of these patients had initially received a secretory carcinoma diagnosis. The primary treatment approach for all patients entailed surgical parotid gland resection. The overall survival (OS) for patients with NTRK3 rearrangements amounted to 78 months, with a corresponding progression-free survival (PFS) of 73 months.
Conclusion: in summary, our case series suggests that secretory carcinomas exhibit a favorable clinical course and underscores the pivotal importance of distinguishing secretory carcinomas from other histological subtypes.
{"title":"Clinical Behavior and Molecular Insights of Secretory Carcinoma of Salivary Glands, a Single Center Experience.","authors":"Sara Bassani, Denise Fiorini, Miriam Sara Destefanis, Athena Eliana Arsie, Davide Mulone, Albino Eccher, Matteo Brunelli, Filippo Marani, Daniele Monzani, Gabriele Molteni","doi":"10.1007/s12070-024-04807-4","DOIUrl":"https://doi.org/10.1007/s12070-024-04807-4","url":null,"abstract":"<p><strong>Objective: </strong>the study aimed to characterize the novel entity referred to as secretory carcinoma of the salivary glands.</p><p><strong>Methods: </strong>we comprehensively evaluated 150 patients afflicted by malignant salivary gland tumors who had been under treatment at the University of Verona. Inclusion criteria primarily focused on the availability of paraffin block materials and adequate follow-up data. Subsequently, we conducted a comprehensive Fluorescent In Situ Hybridization (FISH) analysis, utilizing probes targeting NTRK-3, MALM-2, EWRS-1, HER-2, MDM-2, and NTRK1-2.</p><p><strong>Results: </strong>out of the initial cohort, 37 patients met the eligibility criteria for our study. We identified NTRK3 gene rearrangements in four patients (11%), two of whom had mucoepidermoid carcinoma, and the remaining two had acinic cell carcinoma. Notably, none of these patients had initially received a secretory carcinoma diagnosis. The primary treatment approach for all patients entailed surgical parotid gland resection. The overall survival (OS) for patients with NTRK3 rearrangements amounted to 78 months, with a corresponding progression-free survival (PFS) of 73 months.</p><p><strong>Conclusion: </strong>in summary, our case series suggests that secretory carcinomas exhibit a favorable clinical course and underscores the pivotal importance of distinguishing secretory carcinomas from other histological subtypes.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-06-19DOI: 10.1007/s12070-024-04797-3
Tejaswi Gupta, Charu Singh, Silky Silky
Schwannoma is a rare benign encapsulated nerve sheath tumor which originates from Schwann cells. Generally, schwannoma arising from lingual nerve involves the oral tongue and tongue base in the oral cavity. We report a rare case of lingual nerve schwannoma in a 16-year-old girl with complaint of right-side submandibular swelling for last 4-5 years. A diagnosis was established based on computed tomography (CT scan) and fine needle aspiration cytology (FNAC). CT scan showed tumor involving right submandibular region and superiorly reaching up to parapharyngeal space without any intraoral swelling. She underwent excision under general anesthesia (transcervical approach) without any complication. Per operatively, the tumor was found eccentrically placed with relation to the lingual nerve and lingual nerve fibers were splayed over the tumor. The final histopathological results confirmed the diagnosis of schwannoma.
{"title":"Rare case of Lingual Nerve Schwannoma Presenting as Submandibular Area Swelling with Parapharyngeal Extension.","authors":"Tejaswi Gupta, Charu Singh, Silky Silky","doi":"10.1007/s12070-024-04797-3","DOIUrl":"https://doi.org/10.1007/s12070-024-04797-3","url":null,"abstract":"<p><p>Schwannoma is a rare benign encapsulated nerve sheath tumor which originates from Schwann cells. Generally, schwannoma arising from lingual nerve involves the oral tongue and tongue base in the oral cavity. We report a rare case of lingual nerve schwannoma in a 16-year-old girl with complaint of right-side submandibular swelling for last 4-5 years. A diagnosis was established based on computed tomography (CT scan) and fine needle aspiration cytology (FNAC). CT scan showed tumor involving right submandibular region and superiorly reaching up to parapharyngeal space without any intraoral swelling. She underwent excision under general anesthesia (transcervical approach) without any complication. Per operatively, the tumor was found eccentrically placed with relation to the lingual nerve and lingual nerve fibers were splayed over the tumor. The final histopathological results confirmed the diagnosis of schwannoma.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Kiss of death\" an Unusual case Encountered in ENT Emergency.","authors":"Aditya Gargava, Nishta Tiwari, Manish Nigam, Shiv Kumar Raghuwanshi","doi":"10.1007/s12070-024-04923-1","DOIUrl":"https://doi.org/10.1007/s12070-024-04923-1","url":null,"abstract":"","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-05-27DOI: 10.1007/s12070-024-04760-2
Divya Sethi, B K Prasad, Manoj Gopinath
To compare the depth of mastoid antrum on High Resolution Computed Tomography and per operatively in cases undergoing mastoidectomy. This prospective observational study was done in a tertiary care Army Hospital with 35 patients meriting cortical mastoidectomy surgery. The patients underwent HRCT of temporal bone as a routine pre-operative work up, where depth of mastoid antrum was measured from dome of lateral semicircular canal to outer cortex of temporal bone. Depth was also recorded per-operatively with the help of measuring scale. Measurements were correlated and data was analysed statistically. There were 12 male patients and 23 females. 6 patients were < 3 years of age and 29 above. Study included 29 cases of Chronic Otitis Media and 6 of Bilateral Congenital Sensorineural Hearing Loss. Mean depth of mastoid antrum was 1.625 cm ± 0.228 on HRCT, and 1.651 cm ± 0.245 per-operatively. Depths of mastoid antrum on HRCT and per operatively amongst paediatrics as well as adult cases were comparable, but were more than the standard depth of 1 cm in 5 (82.3%) paediatrics cases and ˃1.5 cm in 24 (82.9%) adult patients. In absence of Koerner's Septum, mean HRCT depth was 1.60 cm ± SD 0.23 and per operatively was 1.63 cm ± SD 0.21; whereas in its presence mean HRCT depth was 1.84 cm ± SD 0.069 and per-operatively was 1.85 cm ± SD 0.42. Significant difference in depth was noted between adults and children, and between the cases with or without Koerner's Septum. However, difference in depth was not significant when compared between different genders, laterality of disease or disease pathology.
{"title":"Comparison of Depth of Mastoid Antrum on High Resolution Computed Tomography and Per Operatively in Cases Undergoing Mastoidectomy.","authors":"Divya Sethi, B K Prasad, Manoj Gopinath","doi":"10.1007/s12070-024-04760-2","DOIUrl":"https://doi.org/10.1007/s12070-024-04760-2","url":null,"abstract":"<p><p>To compare the depth of mastoid antrum on High Resolution Computed Tomography and per operatively in cases undergoing mastoidectomy. This prospective observational study was done in a tertiary care Army Hospital with 35 patients meriting cortical mastoidectomy surgery. The patients underwent HRCT of temporal bone as a routine pre-operative work up, where depth of mastoid antrum was measured from dome of lateral semicircular canal to outer cortex of temporal bone. Depth was also recorded per-operatively with the help of measuring scale. Measurements were correlated and data was analysed statistically. There were 12 male patients and 23 females. 6 patients were < 3 years of age and 29 above. Study included 29 cases of Chronic Otitis Media and 6 of Bilateral Congenital Sensorineural Hearing Loss. Mean depth of mastoid antrum was 1.625 cm ± 0.228 on HRCT, and 1.651 cm ± 0.245 per-operatively. Depths of mastoid antrum on HRCT and per operatively amongst paediatrics as well as adult cases were comparable, but were more than the standard depth of 1 cm in 5 (82.3%) paediatrics cases and ˃1.5 cm in 24 (82.9%) adult patients. In absence of Koerner's Septum, mean HRCT depth was 1.60 cm ± SD 0.23 and per operatively was 1.63 cm ± SD 0.21; whereas in its presence mean HRCT depth was 1.84 cm ± SD 0.069 and per-operatively was 1.85 cm ± SD 0.42. Significant difference in depth was noted between adults and children, and between the cases with or without Koerner's Septum. However, difference in depth was not significant when compared between different genders, laterality of disease or disease pathology.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}