Pub Date : 2025-12-01Epub Date: 2025-09-09DOI: 10.1007/s12020-025-04410-9
Gianluca Marzi, Martina Verrienti, Filomena Longo, Camilla Alice Cattaneo, Alberto Gobbo, Katalin Vetralla, Gian Pietro Franzè, Alberto Cossu, Martina Culcasi, Maria Chiara Zatelli, Maria Rosaria Ambrosio
{"title":"Glycated albumin as a diagnostic tool for diabetes mellitus in transfusion-dependent β-thalassemia patients.","authors":"Gianluca Marzi, Martina Verrienti, Filomena Longo, Camilla Alice Cattaneo, Alberto Gobbo, Katalin Vetralla, Gian Pietro Franzè, Alberto Cossu, Martina Culcasi, Maria Chiara Zatelli, Maria Rosaria Ambrosio","doi":"10.1007/s12020-025-04410-9","DOIUrl":"10.1007/s12020-025-04410-9","url":null,"abstract":"","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1187-1196"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12708767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-13DOI: 10.1007/s12020-025-04463-w
Duygu Tutan, Jan Ulfberg, Ülkem Şen Uzeli, Tuba Kayır, Ayşe Erdoğan Kaya, Nilay Bektas Akpinar, Handan Bilgin, Mehmet Berksun Tutan
{"title":"Alpha-Lipoic acid in the management of restless legs syndrome in patients with diabetic neuropathy: A possible novel therapeutic approach.","authors":"Duygu Tutan, Jan Ulfberg, Ülkem Şen Uzeli, Tuba Kayır, Ayşe Erdoğan Kaya, Nilay Bektas Akpinar, Handan Bilgin, Mehmet Berksun Tutan","doi":"10.1007/s12020-025-04463-w","DOIUrl":"10.1007/s12020-025-04463-w","url":null,"abstract":"","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1311-1322"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-09-16DOI: 10.1007/s12020-025-04423-4
Mohammad S Islam, Alexandra M Dumitrescu, Amna Ahmed, Samuel Refetoff, Roy E Weiss
{"title":"Prevalence of pendrin defects in sudanese families with congenital hypothyroidism.","authors":"Mohammad S Islam, Alexandra M Dumitrescu, Amna Ahmed, Samuel Refetoff, Roy E Weiss","doi":"10.1007/s12020-025-04423-4","DOIUrl":"10.1007/s12020-025-04423-4","url":null,"abstract":"","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1339-1349"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-09-04DOI: 10.1007/s12020-025-04412-7
Muhammad Unais, Muskan Malviya
Background: Depression is a common but often underrecognized comorbidity in individuals with diabetes mellitus. Identifying its prevalence can help in early intervention and better management.
Objective: To estimate the proportion of depression in patients with diabetes mellitus using the Hamilton Depression Rating Scale (HAM-D) and to evaluate associations with gender, age, diabetes duration, and comorbid conditions.
Methods: This descriptive cross-sectional study was conducted among 89 diabetic patients attending outpatient services at a tertiary care hospital. Data was collected via structured interviews using the HAM-D [1] questionnaire. A HAM-D score ≥ 8 was considered indicative of depression. Data analysis was conducted using descriptive statistics and subgroup analysis based on gender, age groups, and other variables.
Results: Among 89 patients, 26 (29.2%) were found to have depression. The prevalence was higher in females (36.8%) compared to males (23.5%). Depression was more frequent in older age groups, particularly among patients aged 60-74 years. [Pie chart and bar graphs to be inserted.] CONCLUSION: A significant proportion of diabetic patients exhibit depressive symptoms, particularly older individuals and females. Routine screening using tools like HAM-D can aid in early identification and intervention.
{"title":"Proportion of depression in diabetes patients: A Cross-Sectional study using HAM-D scale.","authors":"Muhammad Unais, Muskan Malviya","doi":"10.1007/s12020-025-04412-7","DOIUrl":"10.1007/s12020-025-04412-7","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common but often underrecognized comorbidity in individuals with diabetes mellitus. Identifying its prevalence can help in early intervention and better management.</p><p><strong>Objective: </strong>To estimate the proportion of depression in patients with diabetes mellitus using the Hamilton Depression Rating Scale (HAM-D) and to evaluate associations with gender, age, diabetes duration, and comorbid conditions.</p><p><strong>Methods: </strong>This descriptive cross-sectional study was conducted among 89 diabetic patients attending outpatient services at a tertiary care hospital. Data was collected via structured interviews using the HAM-D [1] questionnaire. A HAM-D score ≥ 8 was considered indicative of depression. Data analysis was conducted using descriptive statistics and subgroup analysis based on gender, age groups, and other variables.</p><p><strong>Results: </strong>Among 89 patients, 26 (29.2%) were found to have depression. The prevalence was higher in females (36.8%) compared to males (23.5%). Depression was more frequent in older age groups, particularly among patients aged 60-74 years. [Pie chart and bar graphs to be inserted.] CONCLUSION: A significant proportion of diabetic patients exhibit depressive symptoms, particularly older individuals and females. Routine screening using tools like HAM-D can aid in early identification and intervention.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1197-1200"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-23DOI: 10.1007/s12020-025-04458-7
Anat Bel-Ange, Daniel Fux, Dana Zelnik Yovel, Ilia Beberashvili, Ronit Koren, Simona Grozinsky-Glasberg, Shlomit Koren
{"title":"\"Impaired adrenal responsiveness in hemodialysis patients: a low-dose ACTH stimulation test study\".","authors":"Anat Bel-Ange, Daniel Fux, Dana Zelnik Yovel, Ilia Beberashvili, Ronit Koren, Simona Grozinsky-Glasberg, Shlomit Koren","doi":"10.1007/s12020-025-04458-7","DOIUrl":"10.1007/s12020-025-04458-7","url":null,"abstract":"","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1535-1543"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-09-27DOI: 10.1007/s12020-025-04437-y
Naama Fisch-Shvalb, Meytal Bar-Maisels, Michal Yackobovitch-Gavan, Moshe Phillip, Galia Gat-Yablonski
{"title":"Lipocalin-2 levels in children with idiopathic short stature.","authors":"Naama Fisch-Shvalb, Meytal Bar-Maisels, Michal Yackobovitch-Gavan, Moshe Phillip, Galia Gat-Yablonski","doi":"10.1007/s12020-025-04437-y","DOIUrl":"10.1007/s12020-025-04437-y","url":null,"abstract":"","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"890-895"},"PeriodicalIF":2.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12572053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-08-14DOI: 10.1007/s12020-025-04357-x
Qiaoling Zhu, Ru Wang, Fazhan Xu, Cheng Ji, Dandan Yi, Jianfeng Sang
Purpose: Hypocalcemia is a common complication after total thyroidectomy (TT). Several studies have identified risk factors for early biochemical hypocalcemia, nevertheless, the noteworthy symptomatic hypocalcemia has not been considered. This study aims to construct an intuitive predictive model for biochemical and symptomatic hypocalcemia to assist individualized management.
Methods: A retrospective study was conducted on thyroid cancer patients undergoing TT. Two separate patient cohorts were used for model development and external validation, respectively. Data were gathered to identify the risk factors for biochemical (serum calcium <8.0 mg/dL) and symptomatic hypocalcemia by logistic regression. A predictive model was visualized by a nomogram and validated internally and externally.
Results: Of 431 patients studied, 258 (59.9%) developed hypocalcemia including 180 with biochemical hypocalcemia and 196 with symptomatic hypocalcemia, of whom 118 patients had both. Female (OR 2.108, 95% CI 1.166-3.812, P = 0.014) and postoperative PTH decreased ratio ≥ 60% (OR 22.489, 95% CI 13.289-38.058, P < 0.001) were independent risk factors for hypocalcemia, while BMI ≥ 24 kg/m2 (OR 0.567, 95% CI 0.331-0.970, P = 0.038) was a protective factor. Besides, Hashimoto's thyroiditis tended to increase the risk of hypocalcemia (P = 0.082). A nomogram was developed and a predicted probability of exceeding 0.55 suggested a higher risk of hypocalcemia with a sensitivity of 81.8% and a specificity of 82.1%. The internal and external validated areas under the curve (AUC) were 0.860 and 0.862, respectively.
Conclusion: The validated nomogram combining gender, BMI and proportion of PTH reduction may guide the risk identification and stratified management of hypocalcemia after total thyroidectomy.
目的：低钙血症是甲状腺全切除术（TT）后常见的并发症。一些研究已经确定了早期生化性低钙的危险因素，然而，值得注意的症状性低钙尚未被考虑。本研究旨在建立生化及症状性低钙血症的直观预测模型，辅助个体化治疗。方法：对甲状腺癌患者行TT治疗进行回顾性研究。两个独立的患者队列分别用于模型开发和外部验证。结果：在研究的431例患者中，258例（59.9%）发生低钙血症，其中180例为生化低钙血症，196例为症状性低钙血症，其中118例同时存在生化低钙血症。女性（OR 2.108, 95% CI 1.166 ~ 3.812, P = 0.014）和术后PTH降低率≥60% （OR 22.489, 95% CI 13.288 ~ 38.058, OR 0.567, 95% CI 0.331 ~ 0.970, P = 0.038）为保护因素。此外，桥本甲状腺炎倾向于增加低钙血症的风险（P = 0.082）。建立了一个nomogram，预测概率超过0.55表明低钙血症的风险较高，敏感性为81.8%，特异性为82.1%。内、外验证曲线下面积（AUC）分别为0.860和0.862。结论：经验证的结合性别、BMI和甲状旁腺激素降低比例的nomogram，可指导甲状腺全切除术后低钙血症的风险识别和分层处理。
{"title":"Prediction of early biochemical and symptomatic hypocalcemia in thyroid cancer patients after total thyroidectomy.","authors":"Qiaoling Zhu, Ru Wang, Fazhan Xu, Cheng Ji, Dandan Yi, Jianfeng Sang","doi":"10.1007/s12020-025-04357-x","DOIUrl":"10.1007/s12020-025-04357-x","url":null,"abstract":"<p><strong>Purpose: </strong>Hypocalcemia is a common complication after total thyroidectomy (TT). Several studies have identified risk factors for early biochemical hypocalcemia, nevertheless, the noteworthy symptomatic hypocalcemia has not been considered. This study aims to construct an intuitive predictive model for biochemical and symptomatic hypocalcemia to assist individualized management.</p><p><strong>Methods: </strong>A retrospective study was conducted on thyroid cancer patients undergoing TT. Two separate patient cohorts were used for model development and external validation, respectively. Data were gathered to identify the risk factors for biochemical (serum calcium <8.0 mg/dL) and symptomatic hypocalcemia by logistic regression. A predictive model was visualized by a nomogram and validated internally and externally.</p><p><strong>Results: </strong>Of 431 patients studied, 258 (59.9%) developed hypocalcemia including 180 with biochemical hypocalcemia and 196 with symptomatic hypocalcemia, of whom 118 patients had both. Female (OR 2.108, 95% CI 1.166-3.812, P = 0.014) and postoperative PTH decreased ratio ≥ 60% (OR 22.489, 95% CI 13.289-38.058, P < 0.001) were independent risk factors for hypocalcemia, while BMI ≥ 24 kg/m<sup>2</sup> (OR 0.567, 95% CI 0.331-0.970, P = 0.038) was a protective factor. Besides, Hashimoto's thyroiditis tended to increase the risk of hypocalcemia (P = 0.082). A nomogram was developed and a predicted probability of exceeding 0.55 suggested a higher risk of hypocalcemia with a sensitivity of 81.8% and a specificity of 82.1%. The internal and external validated areas under the curve (AUC) were 0.860 and 0.862, respectively.</p><p><strong>Conclusion: </strong>The validated nomogram combining gender, BMI and proportion of PTH reduction may guide the risk identification and stratified management of hypocalcemia after total thyroidectomy.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"896-907"},"PeriodicalIF":2.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号