Critical Care and Resuscitation最新文献

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A tribute to Rinaldo Bellomo: Why randomised behaviour is better than random behaviour 向Rinaldo Bellomo致敬：为什么随机行为比随机行为更好

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100123

John A. Myburgh MBBCh PhD DSc, FCICM, Balasubramanian Venkatesh MD, FCICM

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Sedation Practice in Intensive Care Evaluation, SPICE and beyond, Rinaldo’s legacy in sedation and delirium research 重症监护评估中的镇静实践，SPICE及其他，Rinaldo在镇静和谵妄研究中的遗产

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100142

Yahya Shehabi MBBS, PhD, EMBA, FCICM, FANZCA, Michael C. Reade MBBS, MPH, DPhil, DMedSc, GAICD, AFRACMA, FHEA, FCCM, FANZCA, FCICM

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Rinaldo Bellomo and the ‘Dark Arts’ of clinical trials 里纳尔多·贝洛莫和临床试验的“黑魔法”

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100146

Steve A. Webb MBBS, PhD, Alisa M. Higgins BPhysio(Hons), PhD

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Rinaldo Bellomo: A clinician with a passion for preclinical research 里纳尔多·贝洛莫：一位对临床前研究充满热情的临床医生

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100128

Clive N. May PhD , Yugeesh R. Lankadeva PhD , Shailesh Bihari PhD

Professor Rinaldo Bellomo was a pioneer in intensive care medicine whose influence extended beyond clinical trials to preclinical and translational research. His long-standing collaboration with the Florey Institute established ovine sepsis models that overturned dogma, demonstrating that septic acute kidney injury can occur despite increased renal blood flow, and clarifying the effects of fluids, noradrenaline, vasopressin, and angiotensin II. These studies advanced understanding of renal medullary hypoperfusion and hypoxia, guided antioxidant strategies, and inspired clinical investigation of megadose sodium ascorbate. Rinaldo also championed integration of preclinical science into the ANZICS Clinical Trials Group, legitimising dedicated sessions, fostering collaboration, and ensuring basic discoveries informed hypothesis-driven clinical trials. A gifted mentor and communicator, he inspired generations of researchers with his curiosity, humility, and passion for physiology. His legacy as both clinician and scientist underscores the enduring value of discovery research in advancing critical care.

Rinaldo Bellomo教授是重症监护医学的先驱，其影响从临床试验扩展到临床前和转化研究。他与弗洛里研究所的长期合作建立了羊脓毒症模型，推翻了以往的教条，证明尽管肾血流量增加，脓毒性急性肾损伤仍可能发生，并阐明了液体、去甲肾上腺素、血管加压素和血管紧张素II的作用。这些研究促进了对肾髓质灌注不足和缺氧的认识，指导了抗氧化策略，并启发了大剂量抗坏血酸钠的临床研究。Rinaldo还倡导将临床前科学纳入ANZICS临床试验小组，使专门会议合法化，促进合作，并确保基本发现为假设驱动的临床试验提供信息。他是一位天才导师和沟通者，他的好奇心、谦逊和对生理学的热情激励了一代又一代的研究人员。他作为临床医生和科学家的遗产强调了发现研究在推进重症监护方面的持久价值。

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Science-based fluid therapy in the intensive care unit: Professor Rinaldo Bellomo’s legacy 重症监护室的科学液体疗法：里纳尔多·贝洛莫教授的遗产

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100145

Simon R. Finfer DrMed , Naomi E. Hammond PhD , John A. Myburgh PhD

Research into the use of resuscitation and “maintenance” fluids in the intensive care unit was integral to the development of the Australian and New Zealand Intensive Care Society Clinical Trials Group (CTG) and the CTG being recognised as one of the most productive and influential trials groups in the world. Professor Rinaldo Bellomo (Rinaldo) played a central and critical role in this research and in this article; we focus on Rinaldo’s many roles and contributions to the key large clinical trials that changed the critical care research landscape in Australia and New Zealand and clinical practice worldwide. With a proposed recruitment of 7000 participants, the Saline versus Albumin Fluid Evaluation study was the first large pragmatic trial conducted in intensive care units anywhere in the world. Rinaldo brought the concept of the trial to the CTG and was critical to securing funding from multiple sources at a time when Australian National Health and Medical Research Council’s funding limits would cover only a fraction of the costs of such a trial. His personal contacts at CSL Ltd. and the Australian Red Cross Blood Service helped secure the supply of study fluids and made possible the seemingly impossible task of blinding a trial of two fluids that were macroscopically different with one supplied in glass bottles and the other in polyvinyl chloride bags. The successful conduct of the Saline versus Albumin Fluid Evaluation trial, the CTG’s first publication in The New England Journal of Medicine and presentation at the US Food and Drugs Administration, established the CTG on the global stage and served as a template for the Crystalloid versus Hydroxyethyl Starch Study and PlasmaLyte-148® versus Saline Study trials; we can only speculate what fraction of this could have been achieved without Rinaldo.

对在重症监护室使用复苏和“维持”液体的研究是澳大利亚和新西兰重症监护学会临床试验小组发展的组成部分，该小组被认为是世界上最有成效和最有影响力的试验小组之一。教授里纳尔多贝洛莫（里纳尔多）在这项研究和这篇文章中发挥了核心和关键作用；我们专注于Rinaldo在关键的大型临床试验中的许多角色和贡献，这些试验改变了澳大利亚和新西兰以及全球临床实践的重症监护研究格局。盐水与白蛋白液评估研究计划招募7000名参与者，是世界上第一个在重症监护病房进行的大型实用试验。Rinaldo向CTG提出了试验的概念，在澳大利亚国家卫生和医学研究委员会的资金限制只能支付此类试验费用的一小部分时，他对从多个来源获得资金至关重要。他在CSL有限公司和澳大利亚红十字会血液服务中心的个人联系帮助确保了研究液体的供应，并使一项看似不可能完成的任务成为可能，即对两种宏观上不同的液体进行盲化试验，一种用玻璃瓶供应，另一种用聚氯乙烯袋供应。CTG首次在《新英格兰医学杂志》（The New England Journal of Medicine）上发表，并在美国食品和药物管理局（US Food and drug Administration）上发表，CTG的成功开展使CTG登上了全球舞台，并成为Crystalloid与羟乙基淀粉研究和PlasmaLyte-148®与生理盐水研究试验的模板；我们只能推测，如果没有雷纳尔多，这一成绩能达到多少。

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Rinaldo Bellomo's contribution to trauma and traumatic brain injury research 雷纳多·贝洛莫对创伤和创伤性脑损伤研究的贡献

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100130

Craig French

引用次数: 0

Professor Rinaldo Bellomo: Founder, architect, and choreographer of critical care nephrology 教授里纳尔多·贝洛莫：创始人，建筑师和危重病肾病学的编舞

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100150

Sean M. Bagshaw MD, MSc, FRCPC, FCAHS , John A. Kellum MD, MCCM

The field of critical care nephrology recently lost one of its founders and champions. From his seminal and revolutionary investigations into the pathophysiology of sepsis-induced AKI to his relentless efforts to improve the care of patients with AKI through drugs and devices, Rinaldo Bellomo was a larger-than-life figure in intensive care medicine. He was a visionary leader, mentor and thinker and yes, an unrelenting challenger of conventional wisdom. He will be missed by his many friends and collaborators around the world. We are thankful to have walked alongside him and to have been inspired by his humble enthusiasm, openness, and limitless curiosity.

重症监护肾病学领域最近失去了一位创始人和冠军。从他对败血症引起的AKI的病理生理学的开创性和革命性的研究，到他通过药物和设备不懈地努力改善AKI患者的护理，里纳尔多·贝洛莫是重症监护医学界的传奇人物。他是一位有远见的领袖、导师和思想家，当然，他也是传统智慧的不懈挑战者。他在世界各地的许多朋友和合作者将怀念他。我们很感激能与他并肩而行，被他谦逊的热情、开放的态度和无限的好奇心所激励。

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Rinaldo Bellomo's seminal contribution to observational research using the ANZICS CORE registry Rinaldo Bellomo对使用ANZICS CORE注册表进行观察研究的开创性贡献

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100140

Michael Bailey PhD , Sean M. Bagshaw MD, MSc , Graeme K. Hart MBBS , David Pilcher MBBS

Rinaldo Bellomo advanced critical care not only through randomised trials but also through rigorous use of observational data, particularly from the ANZICS Centre for Outcome and Resource Evaluation (ANZICS CORE) Registry. At a time when retrospective analyses were often confined to hypothesis generation, he showed that carefully curated, clinically grounded registry studies could inform policy and change practice. Recognising early the potential of ANZICS CORE to become a leading registry, he worked to strengthen its data architecture and published in journals such as The New England Journal of Medicine and JAMA, helping to spark global dialogue and shape guidelines. Using the Adult Patient Database, he described epidemiological trends, identified clinically relevant questions, designed, justified and evaluated randomised trials, and monitored the uptake of evidence-based practice. His work addressed key challenges in sepsis, acute kidney injury, glycaemic control, temperature management and health equity, and was marked by clear case definitions, extensive sensitivity analyses and transparent reporting. This article reviews selected contributions using ANZICS CORE data and outlines how his legacy endures through the value of these datasets and the many researchers he mentored.

Rinaldo Bellomo不仅通过随机试验，而且通过严格使用观察数据，特别是来自ANZICS结果和资源评估中心（ANZICS CORE）注册中心的观察数据，提高了重症监护水平。在回顾性分析通常局限于假设生成的时代，他表明，精心策划的、临床基础的注册研究可以为政策和改变实践提供信息。他很早就认识到ANZICS CORE成为领先注册中心的潜力，致力于加强其数据架构，并在《新英格兰医学杂志》和《美国医学会杂志》等期刊上发表文章，帮助引发全球对话并制定指导方针。利用成人患者数据库，他描述了流行病学趋势，确定了临床相关问题，设计、证明和评估了随机试验，并监测了循证实践的采用情况。他的工作解决了败血症、急性肾损伤、血糖控制、体温管理和健康公平方面的关键挑战，并以明确的病例定义、广泛的敏感性分析和透明的报告为标志。本文回顾了使用ANZICS CORE数据的精选贡献，并概述了他的遗产如何通过这些数据集和他指导的许多研究人员的价值而持久。

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One hundred trials of solitude: A call to action 孤独的一百次考验：行动的呼唤

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100122

Glenn Eastwood

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Rinaldo Bellomo and the evolution of critical care survivorship 里纳尔多·贝洛莫和重症监护生存的演变

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation

Pub Date : 2025-09-01 DOI: 10.1016/j.ccrj.2025.100143

Carol L. Hodgson PhD, PT, Sue Berney BPhysio, PhD

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