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Blood Transfusion最新文献

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Which should be the target for preoperative hemoglobin optimization? 术前优化血红蛋白的目标是什么?
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-22 DOI: 10.2450/BloodTransfus.945
Daniel Ariza-Villanueva, Donat R Spahn, Andrés Cobos-Díaz
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引用次数: 0
Physiologic transfusion thresholds, better than using Hb-based thresholds? 生理输血阈值优于基于血液学的阈值?
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-22 DOI: 10.2450/BloodTransfus.901
Matthias Noitz, Martin W Dünser, Tina Tomić Mahečić, Jens Meier
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引用次数: 0
Viscoelastic monitoring of direct oral anticoagulants (DOAC). 直接口服抗凝剂(DOAC)的粘弹性监测。
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-22 DOI: 10.2450/BloodTransfus.867
Lidia Mora, Laura Pons-Pellicé, Manuel Quintana-Díaz
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引用次数: 0
PBM and ERAS: mandatory bedfellows. PBM和ERAS:强制性的同床异梦。
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-22 DOI: 10.2450/BloodTransfus.876
Henrik Kehlet
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引用次数: 0
Anemia is a disease, not a number. 贫血是一种疾病,而不是一个数字。
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-22 DOI: 10.2450/BloodTransfus.897
Shane C Coy, Matthew A Warner
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引用次数: 0
Restrictive versus liberal transfusion thresholds: lights and shadow. 限制性与自由输血阈值:光明与阴影。
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-22 DOI: 10.2450/BloodTransfus.884
Massimo Franchini, Matteo Zani, Daniele Focosi
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引用次数: 0
Postoperative anemia: is there a role for iron replacement therapy? 术后贫血:铁替代治疗是否有作用?
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-22 DOI: 10.2450/BloodTransfus.906
Elvira Bisbe
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引用次数: 0
Reticulocyte hemoglobin in the evaluation of erythropoietic activity and iron availability. 网织红细胞血红蛋白在红细胞生成活性和铁可用性的评价。
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-22 DOI: 10.2450/BloodTransfus.893
Eloísa Urrechaga, Mónica Fernández
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引用次数: 0
SARS-CoV-2 infection rebound among patients receiving antiviral agents, convalescent plasma, or no treatment: a systematic review with meta-analysis. 接受抗病毒药物、康复血浆或不接受治疗的患者中 SARS-CoV-2 感染的反弹:系统回顾与荟萃分析。
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-05-27 DOI: 10.2450/BloodTransfus.764
Mario Cruciani, Ilaria Pati, Francesca Masiello, Vanessa Piccinini, Simonetta Pupella, Vincenzo De Angelis

Background: There is some evidence showing rebound of COVID-19 infections in patients treated with nirmatrelvir-ritonavir between 2 and 8 days following cessation of the antiviral treatment. COVID-19 rebound is not unique to patients treated with nirmatrelvir-ritonavir, but is also observed in molnupiravir recipients, in patients who did not receive any antiviral treatment and in patients who received convalescent plasma (CP).

Materials and methods: This was a systematic review with meta-analysis of clinical trials evaluating rates of virologic and clinical rebound in COVID-19 patients receiving antiviral agents, CP or no treatment. Both randomized clinical trials and controlled cohort studies were considered. The methodological quality of trials was assessed using ROB-2 and ROBIN-1 checklists, and the GRADE approach.

Results: Data were available from 16 trials. The occurrence of virologic rebound was more commonly observed among nirmatrelvir recipients than among untreated patients (relative risk [RR]=2.12; 95% confidence interval [CI]: 1.38-3.28; p=0.0007). No differences were observed in the occurrence of virologic rebound between nirmatrelvir-ritonavir and molnupiravir recipients (RR=1.01; 95% CI: 0.71-1.43). Similar rates of virologic rebounds were observed in molnupiravir recipients and untreated patients (RR=1.14; 95% CI: 0.81-1.6). One study in the pre-omicron period compared rates of virologic rebound between patients receiving standard of care with or without CP: no differences were observed between groups (RR=1.04; 95% CI: 0.55-1.99). Rates of clinical rebound were reported in seven trials, five evaluating nirmatrelvir-ritonavir and untreated patients, and two evaluating nirmatrelvir-ritonavir and molnupiravir recipients. No statistically significant differences between groups were observed. For all these comparisons, the certainty of the available evidence was graded as low or moderate.

Discussion: Virologic rebound of COVID-19 infections appears to be mild and self-limited, and was observed more commonly in nirmatrelvir-ritonavir recipients than in untreated patients, but was also observed in patients treated with molnupiravir or CP.

背景:有证据显示,在停止抗病毒治疗后的 2 到 8 天内,接受尼马瑞韦-利托那韦治疗的患者会出现 COVID-19 感染反弹。COVID-19反弹并不是尼马瑞韦-利托那韦治疗患者所独有的,在接受莫仑吡韦治疗的患者、未接受任何抗病毒治疗的患者以及接受康复血浆(CP)治疗的患者中也可观察到COVID-19反弹:这是一项系统性回顾和荟萃分析临床试验,评估了接受抗病毒药物、CP 或未接受治疗的 COVID-19 患者的病毒学和临床反弹率。随机临床试验和对照队列研究均在考虑之列。采用ROB-2和ROBIN-1检查表以及GRADE方法对试验的方法学质量进行了评估:结果:16 项试验提供了数据。与未经治疗的患者相比,接受尼尔马特韦治疗的患者更容易出现病毒学反弹(相对风险 [RR]=2.12; 95% 置信区间 [CI]: 1.38-3.28; p=0.0007)。尼马瑞韦-利托那韦和molnupiravir受试者之间的病毒学反弹发生率没有差异(RR=1.01;95% CI:0.71-1.43)。在接受莫仑吡拉韦治疗的患者和未接受治疗的患者中观察到相似的病毒学反弹率(RR=1.14;95% CI:0.81-1.6)。有一项研究比较了接受标准治疗和未接受 CP 治疗的患者的病毒学反弹率:未观察到组间差异(RR=1.04;95% CI:0.55-1.99)。有七项试验报告了临床反弹率,其中五项评估了接受奈马瑞韦-利托那韦治疗的患者和未接受治疗的患者,两项评估了接受奈马瑞韦-利托那韦治疗的患者和接受莫仑匹拉韦治疗的患者。没有观察到组间有明显的统计学差异。在所有这些比较中,现有证据的确定性被评为低度或中度:讨论:COVID-19感染的病毒学反弹似乎是轻微的、自限性的,与未接受过治疗的患者相比,在接受过尼马瑞韦-利托那韦治疗的患者中更常观察到这种反弹,但在接受过莫仑吡韦或CP治疗的患者中也可观察到这种反弹。
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引用次数: 0
Recurrent disease after a matched sibling hematopoietic transplant in an aplastic anemia patient with a disease risk allele, HLA-B*40:02. 一名再生障碍性贫血患者在接受配型成功的同胞造血移植后病情复发,而该患者具有患病风险等位基因 HLA-B*40:02。
IF 2.4 3区 医学 Q2 HEMATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.2450/BloodTransfus.674
Akshita Khosla, Yoshitaka Inoue, Joseph Cioccio, Kevin Rakszawski, Natthapol Songdej, Myles Nickolich, Hong Zheng, Seema Naik, Christopher Ehmann, David Claxton, Witold Rybka, Jeffrey Sivik, Joseph Mierski, Brooke Silar, Caitlin Vajdic, Raymond Hohl, Hiroko Shike, Shin Mineishi, Kentaro Minagawa
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引用次数: 0
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Blood Transfusion
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