Pub Date : 2025-03-01Epub Date: 2025-01-21DOI: 10.2450/BloodTransfus.974
Michael Makris, Cedric Hermans
{"title":"Cryoprecipitate should not be the essential medicine recommended by the WHO to treat hemophilia.","authors":"Michael Makris, Cedric Hermans","doi":"10.2450/BloodTransfus.974","DOIUrl":"10.2450/BloodTransfus.974","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"187-188"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-01-21DOI: 10.2450/BloodTransfus.982
Glenn F Pierce, Brian O'Mahony, Radoslaw Kaczmarek, Salome Mekhuzla, Mark W Skinner
{"title":"Recommending defunct therapies is a safety risk for hemophilia.","authors":"Glenn F Pierce, Brian O'Mahony, Radoslaw Kaczmarek, Salome Mekhuzla, Mark W Skinner","doi":"10.2450/BloodTransfus.982","DOIUrl":"10.2450/BloodTransfus.982","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"189-190"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-12-16DOI: 10.2450/BloodTransfus.894
Fabio Candura, Ilaria Pati, Lucia De Fulvio, Maria Simona Massari, Vanessa Piccinini, Simonetta Pupella, Giacomo Silvioli, Matteo Bolcato, Monica Sane Schepisi, Massimo La Raja, Roberto Bruni, Anna Rita Ciccaglione, Giulio Pisani, Livia Cannata, Raffaele Donadio, Daniele Prati, Vincenzo De Angelis
Parvovirus B19 (B19V) presents a significant concern in the context of blood transfusion safety, given its potential for transmission through contaminated blood products, and the increased viral circulation recently reported across Europe. This study examines the recent epidemiological trends of B19V in Italy, where a notable increase in B19V-positive plasma units was observed during early 2024. While routine NAT testing for B19V in individual blood donations is not currently justified, the existing screening protocols for plasma intended for industrial fractionation are crucial to ensure the safety of plasma-derived medicinal products. However, this situation requires careful consideration of the optimal management of viremic donors and the implementation of targeted look back procedures to trace and monitor recipients of labile blood components. To address these issues, we propose an algorithm for managing both donors and recipients in cases of B19V positivity. These measures aim to balance recipient safety with minimising donor loss, while also addressing significant operational and ethical considerations within blood establishments.
{"title":"Comprehensive analysis of parvovirus B19 infection in blood donors: epidemiological trend and implications for transfusion safety and management strategies in Italy.","authors":"Fabio Candura, Ilaria Pati, Lucia De Fulvio, Maria Simona Massari, Vanessa Piccinini, Simonetta Pupella, Giacomo Silvioli, Matteo Bolcato, Monica Sane Schepisi, Massimo La Raja, Roberto Bruni, Anna Rita Ciccaglione, Giulio Pisani, Livia Cannata, Raffaele Donadio, Daniele Prati, Vincenzo De Angelis","doi":"10.2450/BloodTransfus.894","DOIUrl":"10.2450/BloodTransfus.894","url":null,"abstract":"<p><p>Parvovirus B19 (B19V) presents a significant concern in the context of blood transfusion safety, given its potential for transmission through contaminated blood products, and the increased viral circulation recently reported across Europe. This study examines the recent epidemiological trends of B19V in Italy, where a notable increase in B19V-positive plasma units was observed during early 2024. While routine NAT testing for B19V in individual blood donations is not currently justified, the existing screening protocols for plasma intended for industrial fractionation are crucial to ensure the safety of plasma-derived medicinal products. However, this situation requires careful consideration of the optimal management of viremic donors and the implementation of targeted look back procedures to trace and monitor recipients of labile blood components. To address these issues, we propose an algorithm for managing both donors and recipients in cases of B19V positivity. These measures aim to balance recipient safety with minimising donor loss, while also addressing significant operational and ethical considerations within blood establishments.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"168-175"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-01-29DOI: 10.2450/BloodTransfus.712
Frederik B Clausen, C Ellen van der Schoot
Noninvasive fetal blood group antigen genotyping serves as a diagnostic tool to predict the risk of hemolytic disease of the fetus and newborn in pregnancies of immunized women. In addition, fetal RHD genotyping is used as an antenatal screening to guide targeted use of immunoglobulin prophylaxis in non-immunized RhD negative, pregnant women. Based on testing of cell-free DNA extracted from maternal plasma, these noninvasive assays demonstrate high performance accuracies. Consequently, noninvasive fetal blood group antigen genotyping has become standard care in transfusion medicine.
无创胎儿血型抗原基因分型可作为一种诊断工具，用于预测已接受免疫的孕妇的胎儿和新生儿患溶血性疾病的风险。此外，胎儿 RHD 基因分型还可用作产前筛查，以指导未接受免疫的 RhD 阴性孕妇有针对性地使用免疫球蛋白进行预防。这些无创检测基于对从母体血浆中提取的无细胞 DNA 的检测，具有很高的准确性。因此，无创胎儿血型抗原基因分型已成为输血医学的标准疗法。
{"title":"Noninvasive fetal blood group antigen genotyping.","authors":"Frederik B Clausen, C Ellen van der Schoot","doi":"10.2450/BloodTransfus.712","DOIUrl":"10.2450/BloodTransfus.712","url":null,"abstract":"<p><p>Noninvasive fetal blood group antigen genotyping serves as a diagnostic tool to predict the risk of hemolytic disease of the fetus and newborn in pregnancies of immunized women. In addition, fetal RHD genotyping is used as an antenatal screening to guide targeted use of immunoglobulin prophylaxis in non-immunized RhD negative, pregnant women. Based on testing of cell-free DNA extracted from maternal plasma, these noninvasive assays demonstrate high performance accuracies. Consequently, noninvasive fetal blood group antigen genotyping has become standard care in transfusion medicine.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"101-108"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-11-22DOI: 10.2450/BloodTransfus.921
Suma Choorapoikayil, Kai Zacharowski, Patrick Meybohm
{"title":"Safety of intraoperative blood salvage in cancer surgery: what is new?","authors":"Suma Choorapoikayil, Kai Zacharowski, Patrick Meybohm","doi":"10.2450/BloodTransfus.921","DOIUrl":"10.2450/BloodTransfus.921","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"90-92"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.2450/BloodTransfus.1024
Manuel Muñoz, Jens Meier, Anna Falanga
{"title":"Is there no such thing as a free lunch? With Patient Blood Management, maybe there is!","authors":"Manuel Muñoz, Jens Meier, Anna Falanga","doi":"10.2450/BloodTransfus.1024","DOIUrl":"10.2450/BloodTransfus.1024","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":"23 1","pages":"1-4"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-11-22DOI: 10.2450/BloodTransfus.945
Daniel Ariza-Villanueva, Donat R Spahn, Andrés Cobos-Díaz
{"title":"Which should be the target for preoperative hemoglobin optimization?","authors":"Daniel Ariza-Villanueva, Donat R Spahn, Andrés Cobos-Díaz","doi":"10.2450/BloodTransfus.945","DOIUrl":"10.2450/BloodTransfus.945","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"33-36"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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