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Aldehyde free - Bovine Pericardium - A New Option of Graft in Urethral Stricture Treatment.
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-12-20 DOI: 10.1590/S1677-5538.IBJU.2024.9928
Luciano A Favorito, Rodrigo R Vieiralves, Arthur V Batista, Renata S Palopoli, Luis Octavio Hauschild, Lucas A M Uneda, José A D Resende

Objective: The current management for complex urethral strictures commonly uses open reconstruction with buccal mucosa urethroplasty. However, there are multiple situations whereby buccal mucosa is inadequate (pan-urethral stricture or prior buccal harvest) or inappropriate for utilization (heavy tobacco use or oral radiation). Multiple options exist for use as alternatives or adjuncts to buccal mucosa in complex urethral strictures (injectable antifibrotic agents, augmentation urethroplasty with skin flaps, lingual mucosa, bladder mucosa, colonic mucosa, and new developments in tissue engineering for urethral graft material) (1, 2). In the present video, we present a case where we used a new option of graft to treat urethral strictures: the L-Hydro® tissue treatment technology 100% aldehyde free, VIVENDI graft.

Materials and methods: The present study was approved according to the ethical standards of the hospital's institutional committee on experimentation with human beings. A 57 year-old male patient developed a urethral stricture due to prolonged use of a urinary catheter during a previous hospitalization. A cystourethrogram was performed, which revealed a stenosis of the penile urethra measuring 2.5 cm in length. Urethroplasty was proposed for the surgical treatment in this case. We used a longitudinal penile incision with a ventral sagittal urethrotomy in the penile stricture. A free VIVENDI graft was placed into the longitudinal incision in the dorsal urethra and fixed with interrupted suture as dorsal inlay. The ventral urethrotomy was closed over a 16Fr Foley catheter and the skin incision was then closed in layers. The patient will receive post-operative follow-up for 3 months for clinical assessment through symptoms, uroflowmetry, urethroscopy and residual urine volume after urination.

Results: No intraoperative or postoperative complications occurred. The patient could achieve satisfactory voiding and no complication was seen during the three-month follow-up. Four weeks after surgery, he underwent urethroscopy, which revealed a good appearance of the urethra, with no stenosis or signs of infection.

Conclusion: In the present case the use of bovine pericardium graft for the treatment of penile urethral stricture had a good result and can be an option to repair complex urethral strictures. However, the results presented require a larger population group in addition to multicenter studies with longer follow-up time to ensure the findings obtained. Available at: http://www.intbrazjurol.com.br/video-section/20249928_Vieiralves_et_al.

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引用次数: 0
Evidence of restorative therapies in the treatment of Peyronie disease: A narrative review. 治疗佩罗尼氏病的修复疗法证据:叙述性综述。
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.9920
Francesco Costantini Mesquita, Rodrigo Barros, Thiago Fernandes Negris Lima, David Velasquez, Luciano A Favorito, Edoardo Pozzi, James Dornbush, David Miller, Francis Petrella, Ranjith Ramasamy

Objective: To describe the evidence of Platelet Rich Plasma (PRP), Stem cells therapy (SCT) and Extracorporeal shockwave therapy (ESWL) for the treatment of Peyronies disease (PD), including information from the main urological society guidelines.

Materials and methods: A literature review of PubMed articles published between 2000 and 2023 was conducted, utilizing keywords such as "Peyronie's Disease", "Penile curvature", "Platelet Rich Plasma", "Stem cells", and "Extracorporeal shockwave therapy". Only full-text articles in English were included, excluding case reports and opinions.

Results: A considerable number of clinical trials were conducted using PRP penile injections for therapy of PD, showing reduction of curvature, plaque size and improvement in quality of life. Preclinical studies in rats have shown the potential benefit of adipose-derived stem cells, with improvements in erectile function and fibrosis. Human studies with mesenchymal stem cells demonstrated promising results, with reduction of curvature and plaque size. ESWL effects on PD were investigated in randomized clinical trials and demonstrated no significant impact in curvature or plaque size, but reasonable effect on pain control.

Conclusion: Restorative therapies has emerged as an innovative treatment option for PD and the results from current studies appear to be promising and demonstrated good safety profile. Unfortunately, due to scarce evidence, PRP and SCT are still considered experimental by American Urological Association (AUA) and European Association of Urology (EAU) guidelines. ESWT is recommended, by the same guidelines, for pain control only. More high-quality studies with long-term follow-up outcomes are needed to evaluate efficacy and reproducibility of those therapies.

目的描述富血小板血浆(PRP)、干细胞疗法(SCT)和体外冲击波疗法(ESWL)治疗佩罗尼氏病(PD)的证据,包括来自主要泌尿外科学会指南的信息:利用 "佩罗尼氏病"、"阴茎弯曲"、"富血小板血浆"、"干细胞 "和 "体外冲击波疗法 "等关键词,对2000年至2023年间发表的PubMed文章进行了文献综述。只收录全文英文文章,不包括病例报告和观点:大量临床试验显示,PRP 阴茎注射疗法可减少阴茎弯曲、缩小斑块并改善生活质量。对大鼠进行的临床前研究显示,脂肪来源干细胞具有潜在益处,可改善勃起功能和纤维化。使用间充质干细胞进行的人体研究也显示了良好的效果,弯曲度和斑块大小均有所减少。随机临床试验调查了 ESWL 对勃起功能障碍的影响,结果表明 ESWL 对勃起功能障碍的曲度或斑块大小没有显著影响,但对疼痛控制有合理影响:结论:修复疗法已成为治疗椎间盘突出症的一种创新选择,目前的研究结果似乎很有希望,并显示出良好的安全性。遗憾的是,由于证据不足,美国泌尿外科协会(AUA)和欧洲泌尿外科协会(EAU)的指南仍将 PRP 和 SCT 视为试验性疗法。同样的指南建议 ESWT 仅用于控制疼痛。需要更多具有长期随访结果的高质量研究来评估这些疗法的疗效和可重复性。
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引用次数: 0
Tomographic aspect of a giant stone in a bricker urinary diversion. 砖石尿路分流术中巨大结石的断层成像。
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.9919
Luciano A Favorito, Arthur Valdier, André L Diniz, Ana Raquel M Morais, José A de Resende
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引用次数: 0
Development of nerves and vessels in the penis during the human fetal period. 人类胎儿时期阴茎神经和血管的发育。
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.9916
Carla B M Gallo, Waldemar S Costa, Luciano A Favorito, Francisco J B Sampaio

Introduction: Although nerves and vessels of the penis play important role in erection, there are few studies on their development in human fetus. Therefore, the objective of the present study is to analyze, quantitatively, in the corpora cavernosa and corpus spongiosum, the development of the nerves and vessels in the fetal penis at different gestational ages.

Material and methods: Fifty-six fresh, macroscopically normal human fetuses aged from 13 to 36 weeks post-conception (WPC) were used. Gestational age was determined by the foot length criterion. Penises were immediately fixed in 10% formalin, and routinely processed for paraffin embedding, after which tissue sections from the mid-shaft were obtained. We used immunohistochemical staining to analyze the nerves and vessels in the corpus cavernous and in the corpus spongiosum. These elements were identified and quantified as percentage by using the Image-J software.

Results: The quantitative analysis showed that the percentage of nerves varied from 3.03% to 20.35% in the corpora cavernosa and from 1.89% to 23.88% in the corpus spongiosum. The linear regression analysis indicated that nerves growth (incidence) in the corpora cavernosa and corpus spongiosum correlated significantly and positively with fetal age (r2=0.9421, p<0.0001) and (r2=0.9312, p<0.0001), respectively, during the whole fetal period studied. Also, the quantitative analysis showed that the percentage of vessels varies from 2.96% to 12.86% in the corpora cavernosa and from 3.62% to 14.85% in the corpus spongiosum. The linear regression analysis indicated that vessels growth (appearance) in the corpora cavernosa and corpus spongiosum correlated significantly and positively with fetal age (r2=0.8722, p<0.0001) and (r2=0.8218, p<0.0001), respectively, during the whole fetal period studied. In addition, the linear regression analysis demonstrated a more intense growth rate of nerves in the corpus spongiosum during the 2nd trimester of gestation, when compared with nerves in the corpora cavernosa. In addition, the linear regression analysis demonstrated a more intense growth rate of vessels in the corpus spongiosum when compared with the corpora cavernosa, during the whole fetal period studied.

Conclusions: In the fetal period, the human penis undergoes major developmental changes, notably in the content and distribution of nerves and vessels. We found strong correlation between nerves and vessels growth (amount) with fetal age, both in the corpora cavernosa and corpus spongiosum. There is significant greater proportional number of nerves than vessels during the whole fetal period studied. Also, nerves and vessels grow in a more intense rate than that of the corpora cavernosa and corpus spongiosum areas.

简介虽然阴茎的神经和血管在勃起中起着重要作用,但有关它们在人类胎儿中发育的研究却很少。因此,本研究旨在定量分析不同胎龄胎儿阴茎海绵体和阴茎神经及血管的发育情况:材料和方法:使用了 56 个新鲜的、宏观上正常的人类胎儿,其年龄为受孕后 13 周至 36 周(WPC)。胎龄根据足长标准确定。阴茎立即在 10%福尔马林中固定,常规处理后进行石蜡包埋,然后获取中轴的组织切片。我们使用免疫组化染色法分析海绵体和海绵体中的神经和血管。我们使用 Image-J 软件对这些元素进行了识别和百分比量化:定量分析显示,海绵体中神经的百分比从 3.03% 到 20.35% 不等,海绵体中神经的百分比从 1.89% 到 23.88% 不等。线性回归分析表明,阴茎海绵体和海绵体神经的生长(发生率)与胎儿年龄呈显著正相关(r2=0.9421,p结论:在胎儿时期,人类阴茎经历了重大的发育变化,尤其是神经和血管的含量和分布。我们发现神经和血管的生长(数量)与胎儿年龄密切相关,在海绵体和阴茎海绵体中都是如此。在研究的整个胎儿期,神经的比例数量明显多于血管。此外,神经和血管的生长速度比海绵体和海绵体区域的生长速度更快。
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引用次数: 0
Robot-assisted radical nephroureterectomy using the KangDuo Surgical Robot-01 System versus the da Vinci System: a multicenter prospective randomized controlled trial. 使用康多手术机器人-01系统与达芬奇系统的机器人辅助根治性肾切除术:一项多中心前瞻性随机对照试验。
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.0230
Zhongyuan Zhang, Zhenyu Li, Weifeng Xu, Xuan Wang, Shengcai Zhu, Jie Dong, Xiaojun Tian, Wei Zuo, Qi Tang, Zhihua Li, Kunlin Yang, Xiaoqiang Xue, Yingjie Li, Hongxian Zhang, Qiming Zhang, Silu Chen, Zhaoheng Jin, Xuesong Li, Zhigang Ji, Lulin Ma, Ming Liu

Introduction: We aim to compare the safety and effectiveness of the KangDuo (KD)-Surgical Robot-01 (KD-SR-01) system and the da Vinci (DV) system for robot-assisted radical nephroureterectomy (RARNU).

Materials and methods: This multicenter prospective randomized controlled trial was conducted between March 2022 and September 2023. Group 1 included 29 patients undergoing KD-RARNU. Group 2 included 29 patients undergoing DV-RARNU. Patient demographic and clinical characteristics, perioperative data, and follow-up outcomes were collected prospectively and compared between the two groups.

Results: There were no significant differences in patient baseline demographic and preoperative characteristics between the two groups. The success rates in both groups were 100% without conversion to open or laparoscopic surgery or positive surgical margins. No significant difference was observed in docking time [242 (120-951) s vs 253 (62-498) s, P = 0.780], console time [137 (55-290) min vs 105 (62-220) min, P = 0.114], operative time [207 (121-460) min vs 185 (96-305) min, P = 0.091], EBL [50 (10-600) mL vs 50 (10-700) mL, P = 0.507], National Aeronautics and Space Administration Task Load Index scores, and postoperative serum creatinine levels between the two groups. None of the patients showed evidence of distant metastasis, local recurrence, or equipment-related adverse events during the four-week follow-up. One (3.4%) patient in Group 2 experienced postoperative enterovaginal and enterovesical fistulas (Clavien-Dindo grade III).

Conclusions: The KD-SR-01 system is safe and effective for RARNU compared to the DV Si or Xi system. Further randomized controlled studies with larger sample sizes and longer durations are required.

简介我们旨在比较康多(KD)-手术机器人-01(KD-SR-01)系统和达芬奇(DV)系统用于机器人辅助根治性肾切除术(RARNU)的安全性和有效性:这项多中心前瞻性随机对照试验于2022年3月至2023年9月期间进行。第一组包括 29 名接受 KD-RARNU 手术的患者。第2组包括29名接受DV-RARNU治疗的患者。对两组患者的人口统计学特征、临床特征、围手术期数据和随访结果进行了前瞻性收集和比较:结果:两组患者的基本人口统计学特征和术前特征无明显差异。两组手术的成功率均为100%,没有出现转为开腹或腹腔镜手术或手术切缘阳性的情况。对接时间[242(120-951)秒 vs 253(62-498)秒,P = 0.780]、控制台时间[137(55-290)分钟 vs 105(62-220)分钟,P = 0.114]、手术时间[207(121-460)分钟 vs 185(96-305)分钟,P = 0.091]、EBL[50 (10-600) mL vs 50 (10-700) mL,P = 0.507]、美国国家航空航天局任务负荷指数评分以及术后血清肌酐水平在两组之间存在差异。在四周的随访中,没有一名患者出现远处转移、局部复发或与设备相关的不良事件。第二组中有一名(3.4%)患者术后出现肠瘘和肠道瘘(Clavien-Dindo III级):结论:与 DV Si 或 Xi 系统相比,KD-SR-01 系统对 RARNU 安全有效。需要进一步开展样本量更大、持续时间更长的随机对照研究。
{"title":"Robot-assisted radical nephroureterectomy using the KangDuo Surgical Robot-01 System versus the da Vinci System: a multicenter prospective randomized controlled trial.","authors":"Zhongyuan Zhang, Zhenyu Li, Weifeng Xu, Xuan Wang, Shengcai Zhu, Jie Dong, Xiaojun Tian, Wei Zuo, Qi Tang, Zhihua Li, Kunlin Yang, Xiaoqiang Xue, Yingjie Li, Hongxian Zhang, Qiming Zhang, Silu Chen, Zhaoheng Jin, Xuesong Li, Zhigang Ji, Lulin Ma, Ming Liu","doi":"10.1590/S1677-5538.IBJU.2024.0230","DOIUrl":"10.1590/S1677-5538.IBJU.2024.0230","url":null,"abstract":"<p><strong>Introduction: </strong>We aim to compare the safety and effectiveness of the KangDuo (KD)-Surgical Robot-01 (KD-SR-01) system and the da Vinci (DV) system for robot-assisted radical nephroureterectomy (RARNU).</p><p><strong>Materials and methods: </strong>This multicenter prospective randomized controlled trial was conducted between March 2022 and September 2023. Group 1 included 29 patients undergoing KD-RARNU. Group 2 included 29 patients undergoing DV-RARNU. Patient demographic and clinical characteristics, perioperative data, and follow-up outcomes were collected prospectively and compared between the two groups.</p><p><strong>Results: </strong>There were no significant differences in patient baseline demographic and preoperative characteristics between the two groups. The success rates in both groups were 100% without conversion to open or laparoscopic surgery or positive surgical margins. No significant difference was observed in docking time [242 (120-951) s vs 253 (62-498) s, P = 0.780], console time [137 (55-290) min vs 105 (62-220) min, P = 0.114], operative time [207 (121-460) min vs 185 (96-305) min, P = 0.091], EBL [50 (10-600) mL vs 50 (10-700) mL, P = 0.507], National Aeronautics and Space Administration Task Load Index scores, and postoperative serum creatinine levels between the two groups. None of the patients showed evidence of distant metastasis, local recurrence, or equipment-related adverse events during the four-week follow-up. One (3.4%) patient in Group 2 experienced postoperative enterovaginal and enterovesical fistulas (Clavien-Dindo grade III).</p><p><strong>Conclusions: </strong>The KD-SR-01 system is safe and effective for RARNU compared to the DV Si or Xi system. Further randomized controlled studies with larger sample sizes and longer durations are required.</p>","PeriodicalId":49283,"journal":{"name":"International Braz J Urol","volume":"50 ","pages":"727-736"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telesurgery and the International Brazilian Journal of Urology in 2024. 2024 年的《远程手术》和《国际巴西泌尿外科杂志》。
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.06.01
Luciano A Favorito
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引用次数: 0
Single-Port Transvesical Robotic Radical Prostatectomy in a Patient with Hostile Abdomen. 单孔经膀胱机器人前列腺癌根治术在有敌意的腹股沟患者中的应用
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.0333
Sij Hemal, Sina Sobhani

Introduction: Robotic Radical Prostatectomy using the Da-Vinci Single-Port (SP) robot can provide comparable functional and oncological outcomes with potential advantages pertaining to peri-operative morbidity, especially in patients with an extensive history of prior abdominal surgeries (1, 2).

Materials and methods: Our case is a 74-year-old male with a history of diabetes, cardiac bypass, hypertension, and hyperlipidemia, presenting with a PSA of 7.2. His MRI showed a PIRADS-5 lesion in the left apex and mid-gland peripheral zone, and he was diagnosed with unfavorable intermediate-risk prostate cancer after MRI guided fusion biopsy. His BMI was 31, and past surgical history was pertinent for two exploratory laparotomies due to gunshot wounds and a colostomy creation followed by reversal. The standardized steps of robotic radical prostatectomy were carried out using SP robotic platform performed by author SH (3, 4).

Results: Total operative time and estimated blood loss were 210 minutes and 150mL respectively. The patient was discharged on postoperative day one and final pathology showed adenocarcinoma of the prostate Gleason score 4+3=7, pT2NxR0 and negative surgical margins. The patient was continent four weeks after surgery and the PSA continues to be undetectable after three months.

Conclusion: Transvesical Radical prostatectomy using the single port platform provides acceptable oncological and functional outcomes and quicker recovery given decreased risk of ileus and peritoneal irritation. Given that the abdominal cavity is not violated, the risk of bowel or vascular injury is mitigated, especially in patients with a hostile abdomen.

导言:使用 Da-Vinci Single-Port (SP) 机器人进行机器人前列腺根治术可提供相当的功能和肿瘤治疗效果,并在围手术期发病率方面具有潜在优势,尤其是对于既往接受过腹部手术的患者(1, 2):我们的病例是一名 74 岁的男性,有糖尿病、心脏搭桥、高血压和高脂血症病史,PSA 为 7.2。他的核磁共振成像显示左侧顶点和腺体中段外周区有一个 PIRADS-5 病变,在核磁共振成像引导下进行融合活检后,他被诊断为中危前列腺癌。他的体重指数(BMI)为31,既往手术史为两次因枪伤而进行的探查性开腹手术,以及一次结肠造口术后的逆转手术。作者SH(3,4)使用SP机器人平台实施了机器人前列腺癌根治术的标准化步骤:总手术时间和估计失血量分别为 210 分钟和 150 毫升。患者于术后第一天出院,最终病理结果显示前列腺腺癌格里森评分 4+3=7,pT2NxR0,手术切缘阴性。术后四周,患者继续接受治疗,三个月后仍检测不到 PSA:结论:使用单孔平台的经膀胱根治性前列腺切除术可提供可接受的肿瘤和功能结果,而且由于回肠和腹膜刺激的风险降低,术后恢复更快。由于没有侵犯腹腔,肠道或血管损伤的风险得以降低,尤其是对腹部有敌意的患者。
{"title":"Single-Port Transvesical Robotic Radical Prostatectomy in a Patient with Hostile Abdomen.","authors":"Sij Hemal, Sina Sobhani","doi":"10.1590/S1677-5538.IBJU.2024.0333","DOIUrl":"10.1590/S1677-5538.IBJU.2024.0333","url":null,"abstract":"<p><strong>Introduction: </strong>Robotic Radical Prostatectomy using the Da-Vinci Single-Port (SP) robot can provide comparable functional and oncological outcomes with potential advantages pertaining to peri-operative morbidity, especially in patients with an extensive history of prior abdominal surgeries (1, 2).</p><p><strong>Materials and methods: </strong>Our case is a 74-year-old male with a history of diabetes, cardiac bypass, hypertension, and hyperlipidemia, presenting with a PSA of 7.2. His MRI showed a PIRADS-5 lesion in the left apex and mid-gland peripheral zone, and he was diagnosed with unfavorable intermediate-risk prostate cancer after MRI guided fusion biopsy. His BMI was 31, and past surgical history was pertinent for two exploratory laparotomies due to gunshot wounds and a colostomy creation followed by reversal. The standardized steps of robotic radical prostatectomy were carried out using SP robotic platform performed by author SH (3, 4).</p><p><strong>Results: </strong>Total operative time and estimated blood loss were 210 minutes and 150mL respectively. The patient was discharged on postoperative day one and final pathology showed adenocarcinoma of the prostate Gleason score 4+3=7, pT2NxR0 and negative surgical margins. The patient was continent four weeks after surgery and the PSA continues to be undetectable after three months.</p><p><strong>Conclusion: </strong>Transvesical Radical prostatectomy using the single port platform provides acceptable oncological and functional outcomes and quicker recovery given decreased risk of ileus and peritoneal irritation. Given that the abdominal cavity is not violated, the risk of bowel or vascular injury is mitigated, especially in patients with a hostile abdomen.</p>","PeriodicalId":49283,"journal":{"name":"International Braz J Urol","volume":"50 ","pages":"779-780"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are very thin patients at a higher risk of complications when submitted to percutane-ous nephrolithotomy? 非常瘦弱的患者在接受经皮肾镜碎石术时发生并发症的风险是否更高?
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.0341
Priscila Kuriki Vieira Mota, Daniel Beltrame Ferreira, Rafael Felisberto Dias Florencio, David Jacques Cohen, Rodrigo Perrella, Carlos Alfredo Batagello, Claudio Bovolenta Murta, Joaquim Francisco de Almeida Claro, Fabio C Vicentini

Purpose: To assess the impact of thinness on the outcome of the percutaneous nephrolithotomy (PCNL).

Materials and methods: A matched case-control study was performed using a prospectively collected database of all patients who underwent PCNL between June 2011 and October 2021. The patients were stratified into two groups according to their phenotypic characteristics, arbitrarily defined according to their body mass index (BMI): <0kg/m2 (Group 1, very thin patients, G<20) and ≥25 kg/m2 (Group 2, non-thin patients, G≥25). Patients were randomly matched based on Guy's Stone Score (GSS) according to case complexity at a ratio of 1:3.

Results: A total of 204 patients were enrolled in this study: 51 patients (G<20) and 153 controls (G≥25). Complications occurred in 15.2% of the patients, with 5.4% of these complications classified as major complications (Clavien grade ≥ 3). According to complications there were no significant differences between the groups. The overall complication rates were 17.6% in the G<20 and 14.4% in the G≥25 (p = 0.653). The major complication rates were 3.9% in the G<20 and 5.8% in the G≥25 (p=0.429). No differences in transfusion or urinary fistula rates were found.

Conclusions: In this study, very thin patients were not at a higher risk of complications when submitted to PCNL than in those with a BMI of ≥25 kg/m2. Apparently, this technique can be used in these patients, just as it is used in any other type of patient, independently of their BMI.

目的:评估消瘦对经皮肾镜取石术(PCNL)结果的影响:利用前瞻性收集的数据库,对 2011 年 6 月至 2021 年 10 月间接受 PCNL 的所有患者进行了匹配病例对照研究。根据表型特征将患者分为两组,并根据体重指数(BMI)进行任意定义:结果:共有 204 名患者参与了这项研究:51名患者(G结论:在这项研究中,与体重指数≥25 kg/m2 的患者相比,非常瘦的患者在接受 PCNL 时并没有更高的并发症风险。显然,这种技术可以用于这些病人,就像用于其他类型的病人一样,与他们的体重指数无关。
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引用次数: 0
Endoscopic Combined Intrarenal Surgery: best practices and future perspectives. 内镜联合肾内手术:最佳实践与未来展望。
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.9921
Anderson B Pellanda, Fabio C M Torricelli, John Denstedt, Alexandre Danilovic, Giovanni S Marchini, Fabio C Vicentini, Carlos A Batagello, William C Nahas, Eduardo Mazzucchi

Introduction: Endoscopic Combined Intrarenal Surgery (ECIRS) has emerged as a promising technique for the management of large and complex kidney stones, potentially offering advantages over traditional Percutaneous Nephrolithotomy (PCNL). This study aims to evaluate best practices, outcomes, and future perspectives associated with ECIRS.

Materials and methods: A comprehensive PubMed search was conducted from 2008 to 2024, using MESH terms and the following key words: "ECIRS" and "Endoscopic Combined Intrarenal Surgery" The search yielded 157 articles, including retrospective cohort studies, two randomized controlled trials (RCTs), and four meta-analyses comparing ECIRS with PCNL. Most important findings were summarized regarding indications, patient positioning, kidney access, tract size, surgical outcomes, and complications.

Results: ECIRS demonstrated higher stone-free rate, lower complication rate, and a reduced need for multiple procedures compared to traditional PCNL. Additionally, ECIRS has the potential to integrate new technologies to further enhance outcomes.

Conclusion: ECIRS demonstrates significant advantages in the management of large kidney stones. Future research should focus on well-designed RCTs to provide robust evidence of its efficacy, safety, and cost-effectiveness, potentially establishing ECIRS as the first option treatment for complex kidney stones.

导言:内镜联合肾内手术(ECIRS)已成为一种治疗大型复杂肾结石的有前途的技术,与传统的经皮肾镜取石术(PCNL)相比具有潜在优势。本研究旨在评估与 ECIRS 相关的最佳实践、结果和未来前景:从 2008 年到 2024 年,使用 MESH 术语和以下关键词对 PubMed 进行了全面搜索:"搜索共获得 157 篇文章,包括回顾性队列研究、两项随机对照试验 (RCT) 和四项比较 ECIRS 与 PCNL 的荟萃分析。对最重要的研究结果进行了总结,包括适应症、患者定位、肾脏通路、肾道大小、手术效果和并发症:结果:与传统 PCNL 相比,ECIRS 的无结石率更高,并发症发生率更低,而且减少了多次手术的需要。此外,ECIRS 还具有整合新技术以进一步提高疗效的潜力:结论:ECIRS 在治疗大块肾结石方面具有显著优势。未来的研究应侧重于设计良好的 RCT,为其疗效、安全性和成本效益提供有力的证据,从而将 ECIRS 确立为复杂肾结石的首选治疗方法。
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引用次数: 0
Safety and efficacy of vacuum-assisted mini-percutaneous nephrolithotomy for the treatment of renal stone disease: an analysis of stone free status and postoperative infectious complications. 真空辅助迷你经皮肾镜取石术治疗肾结石病的安全性和有效性:无结石状态和术后感染并发症分析。
IF 3.1 3区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-11-01 DOI: 10.1590/S1677-5538.IBJU.2024.0308
Kaushik P Kolanukuduru, Osama Zaytoun, Neeraja Tillu, Asher Mandel, Zachary Dovey, Maurizio Buscarini

Purpose: Vacuum-assisted mini-percutaneous nephrolithotomy (vmPCNL) is being increasingly adopted due to its faster operating times and lower incidence of postoperative infectious complications (IC), however, studies have been limited by small sample sizes. We hypothesize that vmPCNL is an efficacious treatment for renal stone disease with acceptable stone-free rates (SFR) and low incidence of IC. The objectives of this study were to measure SFR three months after surgery, determine the factors influencing SFR, and determine the rates of postoperative IC after vmPCNL.

Materials and methods: Seven hundred and sixty seven patients underwent vmPCNL for the treatment of renal stones > 20 mm at a single institution. Patients underwent postoperative computed tomography at three months to assess SFR. Postoperative fever and SIRS/Sepsis were recorded for individual patients. Multivariate logistics regression was performed to assess predictors of SFR.

Results: The SFR was found to be 73.7% at three months. Stone burden (OR 0.39, 95% CI [0.33-0.46]) and age (OR 1.03, 95% CI [1.01-1.04]) emerged as statistically significant predictors of SFR on multivariate analysis. 5.5% of patients experienced postoperative fever, while 2.9% experienced SIRS/Sepsis.

Conclusions: This is the largest continuous cohort of patients to undergo vmPCNL for stone disease and demonstrates that vmPCNL is safe and efficacious, with an SFR of 74% at three months. The incidence of postoperative fever and SIRS/Sepsis is 5.5% and 2.9% respectively. Further randomized studies with large sample sizes are required to ascertain the rates of these complications in comparison to conventional approaches.

目的:真空辅助迷你经皮肾镜取石术(vmPCNL)因其手术时间短、术后感染性并发症(IC)发生率低而被越来越多地采用,然而,由于样本量较小,研究受到了限制。我们假设,vmPCNL 是一种治疗肾结石病的有效方法,其无石率(SFR)可接受,IC 发生率低。本研究的目的是测量术后三个月的无结石率,确定影响无结石率的因素,并确定 vmPCNL 术后 IC 的发生率:767 名患者在一家医疗机构接受了 vmPCNL 手术,以治疗大于 20 毫米的肾结石。患者术后三个月接受计算机断层扫描以评估 SFR。患者术后发热和 SIRS/Sepsis 均有记录。进行多变量物流回归以评估SFR的预测因素:结果:三个月后的 SFR 为 73.7%。在多变量分析中,结石负荷(OR 0.39,95% CI [0.33-0.46])和年龄(OR 1.03,95% CI [1.01-1.04])成为 SFR 的显著预测因素。5.5%的患者出现术后发热,2.9%的患者出现SIRS/Sepsis:这是连续接受vmPCNL治疗结石病的最大规模患者群,证明了vmPCNL的安全性和有效性,三个月的SFR为74%。术后发热和 SIRS/Sepsis 的发生率分别为 5.5% 和 2.9%。需要进一步开展大样本量的随机研究,以确定这些并发症的发生率与传统方法的比较。
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International Braz J Urol
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