Yohei Otsuka, S. Tomura, T. Toyooka, S. Takeuchi, A. Tomiyama, Tomoko Omura, Daizoh Saito, K. Wada
Background: The pathophysiology of traumatic brain injury (TBI) is caused by the initial physical damage and by the subsequent biochemical damage (secondary brain injury). Oxidative stress is deeply involved in secondary brain injury, so molecular hydrogen therapy may be effective for TBI. Hydrogen gas shows the optimal effect at concentrations of 2% or higher, but can only be used up to 1.3% in the form of a gas cylinder mixed with oxygen gas, which may not be sufficiently effective. The partial pressure of hydrogen increases in proportion to the pressure, so hyperbaric hydrogen therapy (HBH2) is more effective than that at atmospheric pressure. Methods: A total of 120 mice were divided into three groups: TBI + non-treatment group (TBI group; n = 40), TBI + HBH2 group (n = 40), and non-TBI + non-treatment group (sham group; n = 40). The TBI and TBI + HBH2 groups were subjected to moderate cerebral contusion induced by controlled cortical impact. The TBI + HBH2 group received hyperbaric hydrogen therapy at 2 atmospheres for 90 minutes, at 30 minutes after TBI. Brain edema, neuronal cell loss in the injured hippocampus, neurological function, and cognitive function were evaluated. Results: The TBI + HBH2 group showed significantly less cerebral edema (p < 0.05). Residual hippocampal neurons were significantly more numerous in the TBI + HBH2 group on day 28 (p < 0.05). Neurological score and behavioral tests showed the TBI + HBH2 group had significantly reduced hyperactivity on day 14 (p < 0.01). Conclusion: Hyperbaric hydrogen therapy may be effective for posttraumatic secondary brain injury.
{"title":"Hyperbaric hydrogen therapy improves secondary brain injury after head trauma","authors":"Yohei Otsuka, S. Tomura, T. Toyooka, S. Takeuchi, A. Tomiyama, Tomoko Omura, Daizoh Saito, K. Wada","doi":"10.22462/01.01.2023.43","DOIUrl":"https://doi.org/10.22462/01.01.2023.43","url":null,"abstract":"Background: The pathophysiology of traumatic brain injury (TBI) is caused by the initial physical damage and by the subsequent biochemical damage (secondary brain injury). Oxidative stress is deeply involved in secondary brain injury, so molecular hydrogen therapy may be effective for TBI. Hydrogen gas shows the optimal effect at concentrations of 2% or higher, but can only be used up to 1.3% in the form of a gas cylinder mixed with oxygen gas, which may not be sufficiently effective. The partial pressure of hydrogen increases in proportion to the pressure, so hyperbaric hydrogen therapy (HBH2) is more effective than that at atmospheric pressure. Methods: A total of 120 mice were divided into three groups: TBI + non-treatment group (TBI group; n = 40), TBI + HBH2 group (n = 40), and non-TBI + non-treatment group (sham group; n = 40). The TBI and TBI + HBH2 groups were subjected to moderate cerebral contusion induced by controlled cortical impact. The TBI + HBH2 group received hyperbaric hydrogen therapy at 2 atmospheres for 90 minutes, at 30 minutes after TBI. Brain edema, neuronal cell loss in the injured hippocampus, neurological function, and cognitive function were evaluated. Results: The TBI + HBH2 group showed significantly less cerebral edema (p < 0.05). Residual hippocampal neurons were significantly more numerous in the TBI + HBH2 group on day 28 (p < 0.05). Neurological score and behavioral tests showed the TBI + HBH2 group had significantly reduced hyperactivity on day 14 (p < 0.01). Conclusion: Hyperbaric hydrogen therapy may be effective for posttraumatic secondary brain injury.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"63 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82202655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Cerebral radiation necrosis is a rarely encountered in pediatric patients. This case report describes a child with cerebral radiation necrosis who was successfully treated using a corticosteroids, bevacizumab, and hyperbaric oxygenation. Case Report: A 3-year-old boy developed progressive extremity weakness six months after completion of radiation therapy for treatment of a neuroepithelial malignancy. Treatment with corticosteroids and bevacizumab was initiated, but his symptoms did not improve, and he was then referred for hyperbaric oxygen therapy. After completion of 60 hyperbaric treatments, he experienced significant improvements in mobility which remained stable over the next year. Discussion: Cerebral radiation necrosis typically presents in children with symptoms of ataxia or headache. Corticosteroids and bevacizumab are common treatments, but hyperbaric oxygen therapy has also been studied as a therapeutic modality for this condition. When considering the use of hyperbaric oxygenation in pediatric patients, careful attention to treatment planning and patient safety can reduce the risks of adverse events such as middle ear barotrauma and confinement anxiety. Conclusion: Hyperbaric oxygenation, in addition to other available pharmacologic therapies, should be considered for the treatment of pediatric patients with cerebral radiation necrosis.
{"title":"Treatment of pediatric cerebral radiation necrosis using hyperbaric oxygenation","authors":"K. Johnson-Arbor","doi":"10.22462/01.01.2023.4","DOIUrl":"https://doi.org/10.22462/01.01.2023.4","url":null,"abstract":"Introduction: Cerebral radiation necrosis is a rarely encountered in pediatric patients. This case report describes a child with cerebral radiation necrosis who was successfully treated using a corticosteroids, bevacizumab, and hyperbaric oxygenation. Case Report: A 3-year-old boy developed progressive extremity weakness six months after completion of radiation therapy for treatment of a neuroepithelial malignancy. Treatment with corticosteroids and bevacizumab was initiated, but his symptoms did not improve, and he was then referred for hyperbaric oxygen therapy. After completion of 60 hyperbaric treatments, he experienced significant improvements in mobility which remained stable over the next year. Discussion: Cerebral radiation necrosis typically presents in children with symptoms of ataxia or headache. Corticosteroids and bevacizumab are common treatments, but hyperbaric oxygen therapy has also been studied as a therapeutic modality for this condition. When considering the use of hyperbaric oxygenation in pediatric patients, careful attention to treatment planning and patient safety can reduce the risks of adverse events such as middle ear barotrauma and confinement anxiety. Conclusion: Hyperbaric oxygenation, in addition to other available pharmacologic therapies, should be considered for the treatment of pediatric patients with cerebral radiation necrosis.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"16 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81315636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to investigate the effect of hyperbaric oxygen (HBO2) administration applied during cold ischemic time to organs removed from donors before kidney transplantation. A total of 24 rats were divided into three groups: Group 1 was the control group, Group 2 received 60 minutes of HBO2 at 2.5 atmospheres absolute, and Group 3 received 120 minutes of 2.5 ATA HBO2. The renal artery was entered with a polyethylene catheter and perfused with a standard organ preservation solution. Falcon tubes containing organs obtained from rats in Groups 2 and 3 were placed in a box supported by ice blocks. The temperature was kept constant at 4 °C and the box was placed in a pressure tank with 2.5 ATA HBO2. HBO2 was applied for 60 and 120 minutes, respectively. Organ samples were harvested at the end of 24 hours for histopathological evaluation, immunohistochemical analysis of TNF-α and IL-18, TUNEL analysis for apoptosis, and gene expression levels of kidney injury molecule-1 (KIM-1) and caspase-3. In histopathological examinations, hematoxylin and eosin staining was performed and samples were evaluated for tubular necrosis and vacuolization criteria. Group 2 and Group 3 had significant decreases compared to Group 1 in this regard. Immunohistochemical staining was performed for TNF-α, IL-18, and apoptosis levels; significant decreases were found in Groups 2 and 3. There were significant decreases in Groups 2 and 3 for KIM-1 and caspase-3 gene expression levels compared to Group 1, as well. Thus, it was demonstrated that during the cold ischemic time before kidney transplantation, HBO2 administration to organs removed from donors can reduce apoptotic cell numbers, inflammatory cytokine release, and histopathological damage to the organs as well as decreasing the expression of the KIM-1 gene, which is an indicator of kidney damage.
本研究的目的是探讨在冷缺血时间应用高压氧(HBO2)对肾移植前从供体取出的器官的影响。将24只大鼠分为3组:1组为对照组，2组给予2.5个大气压下60分钟的HBO2, 3组给予2.5个大气压下120分钟的HBO2。用聚乙烯导管进入肾动脉，用标准的器官保存液灌注。从第2组和第3组的大鼠身上取下器官，放入装有冰块的盒子中。温度保持在4℃，将箱体置于2.5 ATA HBO2压力罐中。HBO2分别作用60分钟和120分钟。24小时后采集器官标本，进行组织病理学评估、TNF-α和IL-18免疫组化分析、TUNEL细胞凋亡分析、肾损伤分子-1 (KIM-1)和caspase-3基因表达水平分析。在组织病理学检查中，进行苏木精和伊红染色，并评估样本的小管坏死和空泡化标准。与1组相比，2组和3组在这方面有显著降低。免疫组化染色检测TNF-α、IL-18、细胞凋亡水平;第2、3组明显降低。与1组相比，2组和3组的KIM-1和caspase-3基因表达水平也显著降低。由此可见，在肾移植前的冷缺血时期，给药HBO2可以减少供体器官的凋亡细胞数量、炎症细胞因子的释放和对器官的组织病理学损伤，并降低肾损伤指标KIM-1基因的表达。
{"title":"Hyperbaric oxygen administration mitigates the expression of kidney injury molecule-1, inflammatory cytokines, and apoptotic markers during cold ischemic time in kidney transplantation","authors":"Başak Büyük, Özlem Öztopuz","doi":"10.22462/01.01.2023.2","DOIUrl":"https://doi.org/10.22462/01.01.2023.2","url":null,"abstract":"The aim of this study was to investigate the effect of hyperbaric oxygen (HBO2) administration applied during cold ischemic time to organs removed from donors before kidney transplantation. A total of 24 rats were divided into three groups: Group 1 was the control group, Group 2 received 60 minutes of HBO2 at 2.5 atmospheres absolute, and Group 3 received 120 minutes of 2.5 ATA HBO2. The renal artery was entered with a polyethylene catheter and perfused with a standard organ preservation solution. Falcon tubes containing organs obtained from rats in Groups 2 and 3 were placed in a box supported by ice blocks. The temperature was kept constant at 4 °C and the box was placed in a pressure tank with 2.5 ATA HBO2. HBO2 was applied for 60 and 120 minutes, respectively. Organ samples were harvested at the end of 24 hours for histopathological evaluation, immunohistochemical analysis of TNF-α and IL-18, TUNEL analysis for apoptosis, and gene expression levels of kidney injury molecule-1 (KIM-1) and caspase-3. In histopathological examinations, hematoxylin and eosin staining was performed and samples were evaluated for tubular necrosis and vacuolization criteria. Group 2 and Group 3 had significant decreases compared to Group 1 in this regard. Immunohistochemical staining was performed for TNF-α, IL-18, and apoptosis levels; significant decreases were found in Groups 2 and 3. There were significant decreases in Groups 2 and 3 for KIM-1 and caspase-3 gene expression levels compared to Group 1, as well. Thus, it was demonstrated that during the cold ischemic time before kidney transplantation, HBO2 administration to organs removed from donors can reduce apoptotic cell numbers, inflammatory cytokine release, and histopathological damage to the organs as well as decreasing the expression of the KIM-1 gene, which is an indicator of kidney damage.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"56 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83876620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anwei Liu, Xiaogan Hou, Jian-Yun Nie, Q. Wen, Zhi-guo Pan
Decompression sickness (DCS) is a disease caused by abrupt change of extracorporeal pressure, with varying severity. Symptoms range from mild musculoskeletal pain to severe organ dysfunction and death, especially among patients with chronic underlying disease. Here, we report an unusual case of a 49-year-old man who experienced DCS after a dive to a depth of 38 meters. The patient’s symptoms progressed, starting with mild physical discomfort that progressed to disturbance of consciousness on the second morning. During hospitalization, we identified that in addition to DCS he had also developed diabetic ketoacidosis, septic shock, and rhabdomyolysis. After carefully balancing the benefits and risks, we decided to provide a series of supportive treatment to sustain vital signs, including ventilation support, sugar-reducing therapy, fluid replacement, and anti-infection medications. We then administered delayed hyperbaric oxygen (HBO2) when his condition was stable. Ultimately, the patient recovered without any sequelae. This is the first case report of a diver suffering from DCS followed by diabetic ketoacidosis and septic shock. We have learned that when DCS, along with other critical illness is highly suspected, it is essential to assess the condition comprehensively and focus on the principal contradiction.
{"title":"Decompression sickness followed by diabetic ketoacidosis and sepsis shock: an unusual case report","authors":"Anwei Liu, Xiaogan Hou, Jian-Yun Nie, Q. Wen, Zhi-guo Pan","doi":"10.22462/01.01.2023.13","DOIUrl":"https://doi.org/10.22462/01.01.2023.13","url":null,"abstract":"Decompression sickness (DCS) is a disease caused by abrupt change of extracorporeal pressure, with varying severity. Symptoms range from mild musculoskeletal pain to severe organ dysfunction and death, especially among patients with chronic underlying disease. Here, we report an unusual case of a 49-year-old man who experienced DCS after a dive to a depth of 38 meters. The patient’s symptoms progressed, starting with mild physical discomfort that progressed to disturbance of consciousness on the second morning. During hospitalization, we identified that in addition to DCS he had also developed diabetic ketoacidosis, septic shock, and rhabdomyolysis. After carefully balancing the benefits and risks, we decided to provide a series of supportive treatment to sustain vital signs, including ventilation support, sugar-reducing therapy, fluid replacement, and anti-infection medications. We then administered delayed hyperbaric oxygen (HBO2) when his condition was stable. Ultimately, the patient recovered without any sequelae. This is the first case report of a diver suffering from DCS followed by diabetic ketoacidosis and septic shock. We have learned that when DCS, along with other critical illness is highly suspected, it is essential to assess the condition comprehensively and focus on the principal contradiction.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"34 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88958361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dale Parsons, E. Utz, Grant A Kidd, Gina R Virgilio
Inner ear decompression sickness (IEDCS) is an uncommon diving-related injury affecting the vestibulocochlear system, with symptoms typically including vertigo, tinnitus and hearing loss, either in isolation or in combination. Classically associated with deep, mixed-gas diving, more recent case series have shown that IEDCS is indeed possible after seemingly innocuous recreational dives, and there has been one previous report of IEDCS following routine hyperbaric chamber operations. The presence of right-to-left shunt (RLS), dehydration and increases in intrathoracic pressure have been identified as risk factors for IEDCS, and previous studies have shown a predominance of vestibular rather than cochlear symptoms, with a preference for lateralization to the right side. Most importantly, rapid identification and initiation of recompression treatment are critical to preventing long-term or permanent inner ear deficits. This case of a U.S. Navy (USN) diver with previously unidentified RLS reemphasizes the potential for IEDCS following uncomplicated diving and recompression chamber operations – only the second reported instance of the latter.
{"title":"Inner ear decompression sickness after a routine dive and recompression chamber drill: A case report","authors":"Dale Parsons, E. Utz, Grant A Kidd, Gina R Virgilio","doi":"10.22462/01.01.2023.27","DOIUrl":"https://doi.org/10.22462/01.01.2023.27","url":null,"abstract":"Inner ear decompression sickness (IEDCS) is an uncommon diving-related injury affecting the vestibulocochlear system, with symptoms typically including vertigo, tinnitus and hearing loss, either in isolation or in combination. Classically associated with deep, mixed-gas diving, more recent case series have shown that IEDCS is indeed possible after seemingly innocuous recreational dives, and there has been one previous report of IEDCS following routine hyperbaric chamber operations. The presence of right-to-left shunt (RLS), dehydration and increases in intrathoracic pressure have been identified as risk factors for IEDCS, and previous studies have shown a predominance of vestibular rather than cochlear symptoms, with a preference for lateralization to the right side. Most importantly, rapid identification and initiation of recompression treatment are critical to preventing long-term or permanent inner ear deficits. This case of a U.S. Navy (USN) diver with previously unidentified RLS reemphasizes the potential for IEDCS following uncomplicated diving and recompression chamber operations – only the second reported instance of the latter.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75887181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melisa Öçbe, Selin Gamze Sümen, Busra Dilara Altun, A. Dumlu
Barodontalgia, barometric pressure-induced dental pain, may occur during hyperbaric oxygen therapy due to pressure changes. This case report represents an 8-year-old male patient with barodontalgia. The patient declared a severe toothache during hyperbaric therapy. The diving medicine specialist referred the patient to the dental clinician immediately. Upon clinical examination, the pain was thought to be caused by caries lesions of the deciduous teeth in the left maxillary molar region. Tooth extraction was suggested. After extraction, patient continued hyperbaric oxygen therapy sessions without any pain. Patient was recommended for a session to intraoral and radiographic examination one week after the extraction. In conclusion, caries lesions and faulty restorations should be examined before hyperbaric oxygen therapy sessions. Even though barodontalgia is a rare phenomenon, dental examination is essential to avoid these kinds of pain-related complications. All carious lesions and defective restorations must be treated, if necessary. Removal of faulty restorations, and management of inflammation as part of the treatment is suggested before being exposed to pressure changes.
{"title":"Barodontalgia during hyperbaric oxygen therapy of an 8-year-old male: a case report","authors":"Melisa Öçbe, Selin Gamze Sümen, Busra Dilara Altun, A. Dumlu","doi":"10.22462/01.01.2023.29","DOIUrl":"https://doi.org/10.22462/01.01.2023.29","url":null,"abstract":"Barodontalgia, barometric pressure-induced dental pain, may occur during hyperbaric oxygen therapy due to pressure changes. This case report represents an 8-year-old male patient with barodontalgia. The patient declared a severe toothache during hyperbaric therapy. The diving medicine specialist referred the patient to the dental clinician immediately. Upon clinical examination, the pain was thought to be caused by caries lesions of the deciduous teeth in the left maxillary molar region. Tooth extraction was suggested. After extraction, patient continued hyperbaric oxygen therapy sessions without any pain. Patient was recommended for a session to intraoral and radiographic examination one week after the extraction. In conclusion, caries lesions and faulty restorations should be examined before hyperbaric oxygen therapy sessions. Even though barodontalgia is a rare phenomenon, dental examination is essential to avoid these kinds of pain-related complications. All carious lesions and defective restorations must be treated, if necessary. Removal of faulty restorations, and management of inflammation as part of the treatment is suggested before being exposed to pressure changes.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"37 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77794300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. D. Spencer, Tyler Connely, J. Cooper, J. Dowdall
We present two cases of cricoid chondronecrosis treated with hyperbaric oxygen (HBO2) therapy. Both patients presented with biphasic stridor and dyspnea several weeks after an intubation event. Tracheostomy was ultimately performed for airway protection, followed by antibiotic treatment and outpatient HBO2 therapy. Both patients were decannulated within 6 months of presentation and after at least 20 HBO2 therapy sessions. Despite a small sample size, our findings are consistent with data supporting HBO2 therapy’s effects on tissue edema and neovascularization as well as HBO2 potentiation of antibiotic treatment and leukocyte function. We suggest HBO2 therapy may have accelerated airway decannulation by way of infection resolution as well as the revitalization of upper airway tissues, ultimately renewing the structural integrity of the larynx. Physicians should be aware of the potential benefits of HBO2 therapy when presented with this rare but significant clinical challenge.
{"title":"Chondronecrosis of the cricoid treated with hyperbaric oxygen therapy: A case series","authors":"J. D. Spencer, Tyler Connely, J. Cooper, J. Dowdall","doi":"10.22462/01.01.2023.30","DOIUrl":"https://doi.org/10.22462/01.01.2023.30","url":null,"abstract":"We present two cases of cricoid chondronecrosis treated with hyperbaric oxygen (HBO2) therapy. Both patients presented with biphasic stridor and dyspnea several weeks after an intubation event. Tracheostomy was ultimately performed for airway protection, followed by antibiotic treatment and outpatient HBO2 therapy. Both patients were decannulated within 6 months of presentation and after at least 20 HBO2 therapy sessions. Despite a small sample size, our findings are consistent with data supporting HBO2 therapy’s effects on tissue edema and neovascularization as well as HBO2 potentiation of antibiotic treatment and leukocyte function. We suggest HBO2 therapy may have accelerated airway decannulation by way of infection resolution as well as the revitalization of upper airway tissues, ultimately renewing the structural integrity of the larynx. Physicians should be aware of the potential benefits of HBO2 therapy when presented with this rare but significant clinical challenge.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89274306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hayden W. Hess, Z. Schlader, Blair D. Johnson, Riana R. Pryor, D. Hostler
We tested the hypotheses that self-paced aerobic exercise performance is reduced following four hours of cold-water immersion when breathing air and further reduced when breathing 100% oxygen (O2). Nine healthy adults (four women; age 24 ± 3 years; body fat 17.9 ± 6.4 %; V̇O2max 48 ± 9 mL·kg·minute-1) completed three visits: a no-immersion control trial and two experimental trials consisting of a four-hour cold-water immersion (20.1±0.3C) either breathing air (FIO2 = 0.21) or O2 (FIO2 = 1.0). During the no-immersion control trial and following immersion in the experimental trials, subjects first completed a 60-minute ruck-march carrying 20% of body mass in a rucksack, immediately followed by an unweighted, self-paced 5-km time trial on a motorized treadmill. Core temperature, heart rate, and rating of perceived exertion were recorded every 1,000 meters during the 5-km time trial. Data are presented mean ± SD. Time trial performance was reduced following immersion in both the 100% O2 trial (32 ± 6 minutes; p=0.01) and air trial (32 ± 5 minutes; p=0.01) compared to the control trial (28 ± 4 minutes). However, there was no difference between the 100% O2 and air trials (p=0.86). Heart rate, core temperature, and rating of perceived exertion increased during the time trial (time effect: p<0.01), but were not different between trials (trial effect: p≥0.33). These findings suggests that prolonged cold-water immersion attenuates self-paced aerobic exercise performance, but does not appear to be further affected by breathing gas type.
{"title":"Aerobic exercise performance is reduced following prolonged cold-water immersion","authors":"Hayden W. Hess, Z. Schlader, Blair D. Johnson, Riana R. Pryor, D. Hostler","doi":"10.22462/01.01.2023.33","DOIUrl":"https://doi.org/10.22462/01.01.2023.33","url":null,"abstract":"We tested the hypotheses that self-paced aerobic exercise performance is reduced following four hours of cold-water immersion when breathing air and further reduced when breathing 100% oxygen (O2). Nine healthy adults (four women; age 24 ± 3 years; body fat 17.9 ± 6.4 %; V̇O2max 48 ± 9 mL·kg·minute-1) completed three visits: a no-immersion control trial and two experimental trials consisting of a four-hour cold-water immersion (20.1±0.3C) either breathing air (FIO2 = 0.21) or O2 (FIO2 = 1.0). During the no-immersion control trial and following immersion in the experimental trials, subjects first completed a 60-minute ruck-march carrying 20% of body mass in a rucksack, immediately followed by an unweighted, self-paced 5-km time trial on a motorized treadmill. Core temperature, heart rate, and rating of perceived exertion were recorded every 1,000 meters during the 5-km time trial. Data are presented mean ± SD. Time trial performance was reduced following immersion in both the 100% O2 trial (32 ± 6 minutes; p=0.01) and air trial (32 ± 5 minutes; p=0.01) compared to the control trial (28 ± 4 minutes). However, there was no difference between the 100% O2 and air trials (p=0.86). Heart rate, core temperature, and rating of perceived exertion increased during the time trial (time effect: p<0.01), but were not different between trials (trial effect: p≥0.33). These findings suggests that prolonged cold-water immersion attenuates self-paced aerobic exercise performance, but does not appear to be further affected by breathing gas type.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"49 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77618987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Closed-circuit rebreather diving is becoming more common. Rebreathers are complicated, adding to the stress of diving. Also adding to this complexity in the presented case is diving at a high-altitude cold-water reservoir in Colorado. One diver experienced an oxygen-induced seizure at depth. The other diver had a rapid ascent with loss of consciousness. As will be seen in this case, two experienced divers were able to recover from a possible devastating dive. Fortunately, they both returned to their pre-dive baseline health. Dive planning is important, but as in this case, dive execution is paramount. This is a clinical case for an uncommon event that presented to an emergency department.
{"title":"Altitude diving on a closed-circuit oxygen rebreather: A case report","authors":"J. Conard","doi":"10.22462/01.01.2023.12","DOIUrl":"https://doi.org/10.22462/01.01.2023.12","url":null,"abstract":"Closed-circuit rebreather diving is becoming more common. Rebreathers are complicated, adding to the stress of diving. Also adding to this complexity in the presented case is diving at a high-altitude cold-water reservoir in Colorado. One diver experienced an oxygen-induced seizure at depth. The other diver had a rapid ascent with loss of consciousness. As will be seen in this case, two experienced divers were able to recover from a possible devastating dive. Fortunately, they both returned to their pre-dive baseline health. Dive planning is important, but as in this case, dive execution is paramount. This is a clinical case for an uncommon event that presented to an emergency department.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"50 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73438664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koichi Mimura, M. Harada, S. Sumiyoshi, Gyo Toya, M. Takagi, E. Fujita, Akira Takata, S. Tatetsu
On November 9, 1963, during the afternoon shift change at the Miike coal mine, eight rail cars filled with coal broke free and fell 360 meters [1]. The impact ignited coal dust in the mine and set off two explosions, killing 20 people immediately and trapping nearly 1,400 other workers up to 450 meters below the surface and 8 kilometers from the mine entrance. The explosion damaged electrical and telephone lines, but the ventilation fan continued to operate and spread carbon monoxide throughout the mine [1].
{"title":"Long-term eff ects of carbon monoxide poisoning at Miike coal mine: A 33-year follow-up study","authors":"Koichi Mimura, M. Harada, S. Sumiyoshi, Gyo Toya, M. Takagi, E. Fujita, Akira Takata, S. Tatetsu","doi":"10.22462/01.01.2023.40","DOIUrl":"https://doi.org/10.22462/01.01.2023.40","url":null,"abstract":"On November 9, 1963, during the afternoon shift change at the Miike coal mine, eight rail cars filled with coal broke free and fell 360 meters [1]. The impact ignited coal dust in the mine and set off two explosions, killing 20 people immediately and trapping nearly 1,400 other workers up to 450 meters below the surface and 8 kilometers from the mine entrance. The explosion damaged electrical and telephone lines, but the ventilation fan continued to operate and spread carbon monoxide throughout the mine [1].","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75478832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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