首页 > 最新文献

Statistics & Probability Letters最新文献

英文 中文
Large deviations of Gaussian neural networks with ReLU activation 具有ReLU激活的高斯神经网络的大偏差
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-25 DOI: 10.1016/j.spl.2025.110611
Quirin Vogel
We prove a large deviation principle for deep neural networks with Gaussian weights and at most linearly growing activation functions, such as ReLU. This generalizes earlier work, in which bounded and continuous activation functions were considered. In practice, linearly growing activation functions such as ReLU are most commonly used. We furthermore simplify previous expressions for the rate function and provide a power-series expansions for the ReLU case.
我们证明了具有高斯权值和最多线性增长激活函数(如ReLU)的深度神经网络的大偏差原理。这推广了先前的工作,其中考虑了有界和连续的激活函数。在实践中,像ReLU这样的线性增长激活函数是最常用的。我们进一步简化了先前的速率函数表达式,并为ReLU情况提供了幂级数展开式。
{"title":"Large deviations of Gaussian neural networks with ReLU activation","authors":"Quirin Vogel","doi":"10.1016/j.spl.2025.110611","DOIUrl":"10.1016/j.spl.2025.110611","url":null,"abstract":"<div><div>We prove a large deviation principle for deep neural networks with Gaussian weights and at most linearly growing activation functions, such as ReLU. This generalizes earlier work, in which bounded and continuous activation functions were considered. In practice, linearly growing activation functions such as ReLU are most commonly used. We furthermore simplify previous expressions for the rate function and provide a power-series expansions for the ReLU case.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110611"},"PeriodicalIF":0.7,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fitting mixtures of von Mises distributions via noise contrastive estimation 通过噪声对比估计拟合von Mises分布的混合
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-24 DOI: 10.1016/j.spl.2025.110608
Cinzia Di Nuzzo, Salvatore Ingrassia, Luca Scaffidi Domianello
Directional distributions requires the evaluation of complicated normalizing constants, even for the univariate von Mises. For this reason, maximum likelihood estimation methods are often difficult to apply in practice. To address this issue, we present an approach based on Noise Contrastive Estimation (NCE), a statistical learning technique used for parameter estimation in non-normalized statistical models. In NCE, the estimation problem is reformulated as a binary classification task. In this paper, we focus on fitting mixtures of von Mises distributions, with particular emphasis on toroidal data. Our application to real data, in which we compare several estimation methods, suggests that NCE is a promising alternative for parameter inference in finite mixtures of directional distributions.
方向分布需要计算复杂的归一化常数,即使对于单变量von Mises也是如此。由于这个原因,极大似然估计方法在实践中往往难以应用。为了解决这个问题,我们提出了一种基于噪声对比估计(NCE)的方法,这是一种用于非归一化统计模型参数估计的统计学习技术。在NCE中,估计问题被重新表述为一个二元分类任务。在本文中,我们着重于拟合von Mises分布的混合,特别强调环面数据。我们对实际数据的应用,其中我们比较了几种估计方法,表明NCE是在有限混合方向分布中进行参数推断的有希望的替代方法。
{"title":"Fitting mixtures of von Mises distributions via noise contrastive estimation","authors":"Cinzia Di Nuzzo,&nbsp;Salvatore Ingrassia,&nbsp;Luca Scaffidi Domianello","doi":"10.1016/j.spl.2025.110608","DOIUrl":"10.1016/j.spl.2025.110608","url":null,"abstract":"<div><div>Directional distributions requires the evaluation of complicated normalizing constants, even for the univariate von Mises. For this reason, maximum likelihood estimation methods are often difficult to apply in practice. To address this issue, we present an approach based on Noise Contrastive Estimation (NCE), a statistical learning technique used for parameter estimation in non-normalized statistical models. In NCE, the estimation problem is reformulated as a binary classification task. In this paper, we focus on fitting mixtures of von Mises distributions, with particular emphasis on toroidal data. Our application to real data, in which we compare several estimation methods, suggests that NCE is a promising alternative for parameter inference in finite mixtures of directional distributions.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110608"},"PeriodicalIF":0.7,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On elephant random walk with random memory 大象随机漫步,随机记忆
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-24 DOI: 10.1016/j.spl.2025.110610
M. Dhillon, K.K. Kataria
In this paper, we introduce the elephant random walk (ERW) with memory consisting of randomly selected steps from its history. It is a time-changed variant of the standard elephant random walk with memory consisting of its full history. At each time point, the time changing component is the composition of two uniformly distributed independent random variables with support over all the past steps. Several conditional distributional properties including the conditional mean increments and conditional displacement of ERW with random memory are obtained. Using these conditional results, we derive the recursive and explicit expressions for the mean increments and mean displacement of the walk.
本文介绍了大象随机漫步(ERW)算法,该算法的记忆是由其历史中随机选择的步骤组成的。它是标准大象随机行走的一种随时间变化的变体,具有包含其全部历史的记忆。在每个时间点,时间变化分量是两个均匀分布的独立随机变量的组合,对过去的所有步骤都有支持。得到了具有随机记忆的ERW的条件平均增量和条件位移的几个条件分布性质。利用这些条件结果,我们推导出了行走的平均增量和平均位移的递归式和显式表达式。
{"title":"On elephant random walk with random memory","authors":"M. Dhillon,&nbsp;K.K. Kataria","doi":"10.1016/j.spl.2025.110610","DOIUrl":"10.1016/j.spl.2025.110610","url":null,"abstract":"<div><div>In this paper, we introduce the elephant random walk (ERW) with memory consisting of randomly selected steps from its history. It is a time-changed variant of the standard elephant random walk with memory consisting of its full history. At each time point, the time changing component is the composition of two uniformly distributed independent random variables with support over all the past steps. Several conditional distributional properties including the conditional mean increments and conditional displacement of ERW with random memory are obtained. Using these conditional results, we derive the recursive and explicit expressions for the mean increments and mean displacement of the walk.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110610"},"PeriodicalIF":0.7,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An asymptotically exact multiple testing procedure under dependence 依赖条件下的渐近精确多重检验过程
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-22 DOI: 10.1016/j.spl.2025.110609
Swarnadeep Datta , Monitirtha Dey
We propose a simple single-step multiple testing procedure that asymptotically controls the family-wise error rate (FWER) at the desired level exactly under the equicorrelated multivariate Gaussian setup. The method is shown to be asymptotically exact using an explicit plug-in estimator for the equicorrelation, and does not require stepwise adjustments. We establish its theoretical properties, including the convergence to the desired error level (along with an estimate of the rate of convergence), and demonstrate its effectiveness through simulation results. We also spell out related extensions to unknown equicorrelation, block-correlated structures and generalized FWER control.
我们提出了一个简单的单步多重测试程序,该程序在等相关多元高斯设置下,将家庭错误率(FWER)渐进地控制在期望的水平上。该方法被证明是渐进精确的,使用显式插入估计器进行等相关,并且不需要逐步调整。我们建立了它的理论性质,包括收敛到期望的误差水平(以及收敛速度的估计),并通过仿真结果证明了它的有效性。我们还详细阐述了未知等相关、块相关结构和广义FWER控制的相关扩展。
{"title":"An asymptotically exact multiple testing procedure under dependence","authors":"Swarnadeep Datta ,&nbsp;Monitirtha Dey","doi":"10.1016/j.spl.2025.110609","DOIUrl":"10.1016/j.spl.2025.110609","url":null,"abstract":"<div><div>We propose a simple single-step multiple testing procedure that asymptotically controls the family-wise error rate (FWER) at the desired level exactly under the equicorrelated multivariate Gaussian setup. The method is shown to be asymptotically exact using an explicit plug-in estimator for the equicorrelation, and does not require stepwise adjustments. We establish its theoretical properties, including the convergence to the desired error level (along with an estimate of the rate of convergence), and demonstrate its effectiveness through simulation results. We also spell out related extensions to unknown equicorrelation, block-correlated structures and generalized FWER control.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110609"},"PeriodicalIF":0.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trotter-Kato approximations of stochastic evolution equations with local Lipschitz nonlinearities 局部Lipschitz非线性随机演化方程的Trotter-Kato近似
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-22 DOI: 10.1016/j.spl.2025.110605
T.E. Govindan
The paper studies semilinear stochastic evolution equations in a real Hilbert space. The main goal is to consider the Trotter-Kato approximations of mild solutions of such equations using local Lipschitz conditions on the nonlinear terms. The results obtained are new and generalize some of the results from Govindan (2015).
本文研究了实数Hilbert空间中的半线性随机演化方程。主要目的是利用非线性项上的局部Lipschitz条件考虑此类方程温和解的Trotter-Kato近似。获得的结果是新的,并推广了Govindan(2015)的一些结果。
{"title":"Trotter-Kato approximations of stochastic evolution equations with local Lipschitz nonlinearities","authors":"T.E. Govindan","doi":"10.1016/j.spl.2025.110605","DOIUrl":"10.1016/j.spl.2025.110605","url":null,"abstract":"<div><div>The paper studies semilinear stochastic evolution equations in a real Hilbert space. The main goal is to consider the Trotter-Kato approximations of mild solutions of such equations using local Lipschitz conditions on the nonlinear terms. The results obtained are new and generalize some of the results from <span><span>Govindan (2015)</span></span>.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110605"},"PeriodicalIF":0.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A functional limit theorem for self-normalized partial sum processes in the M1 topology M1拓扑中自归一化部分和过程的泛函极限定理
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-21 DOI: 10.1016/j.spl.2025.110607
Danijel Krizmanić
For a stationary sequence of random variables we derive a self-normalized functional limit theorem under joint regular variation with index α(0,2) and weak dependence conditions. The convergence takes place in the space of real-valued càdlàg functions on [0,1] with the Skorokhod M1 topology.
对于平稳随机变量序列,在指数α∈(0,2)和弱相关条件下,导出了一个联合正则变分下的自归一化泛函极限定理。收敛发生在[0,1]上的实值càdlàg函数空间中,具有Skorokhod M1拓扑。
{"title":"A functional limit theorem for self-normalized partial sum processes in the M1 topology","authors":"Danijel Krizmanić","doi":"10.1016/j.spl.2025.110607","DOIUrl":"10.1016/j.spl.2025.110607","url":null,"abstract":"<div><div>For a stationary sequence of random variables we derive a self-normalized functional limit theorem under joint regular variation with index <span><math><mrow><mi>α</mi><mo>∈</mo><mrow><mo>(</mo><mn>0</mn><mo>,</mo><mn>2</mn><mo>)</mo></mrow></mrow></math></span> and weak dependence conditions. The convergence takes place in the space of real-valued càdlàg functions on <span><math><mrow><mo>[</mo><mn>0</mn><mo>,</mo><mn>1</mn><mo>]</mo></mrow></math></span> with the Skorokhod <span><math><msub><mrow><mi>M</mi></mrow><mrow><mn>1</mn></mrow></msub></math></span> topology.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110607"},"PeriodicalIF":0.7,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Power enhancement of permutation-augmented partial-correlation tests via fixed-row permutations 基于定行置换的置换增强型部分相关检验的功率增强
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-21 DOI: 10.1016/j.spl.2025.110591
Tianyi Wang, Guanghui Wang, Zhaojun Wang, Changliang Zou
Permutation-based partial-correlation tests guarantee finite-sample Type I error control under any fixed design and exchangeable noise, yet their power can collapse when the permutation-augmented design aligns too closely with the covariate of interest. We remedy this by fixing a design-driven subset of rows and permuting only the remainder. The fixed rows are chosen by a greedy algorithm that maximizes a lower bound on power. This strategy reduces covariate-permutation collinearity while preserving worst-case Type I error control. Simulations confirm that this refinement maintains nominal size and delivers substantial power gains over original unrestricted permutations, especially in high-collinearity regimes.
基于置换的部分相关测试保证了在任何固定设计和可交换噪声下的有限样本I型误差控制,但是当置换增强设计与感兴趣的协变量过于接近时,它们的能力可能会崩溃。我们通过修复设计驱动的行子集并只排列其余的行来解决这个问题。固定的行由贪心算法选择,贪心算法使幂的下界最大化。该策略在保持最坏情况I型误差控制的同时减少了协变量置换共线性。模拟证实,这种改进保持了标称尺寸,并提供了大量的功率增益比原来的无限制排列,特别是在高共线性制度。
{"title":"Power enhancement of permutation-augmented partial-correlation tests via fixed-row permutations","authors":"Tianyi Wang,&nbsp;Guanghui Wang,&nbsp;Zhaojun Wang,&nbsp;Changliang Zou","doi":"10.1016/j.spl.2025.110591","DOIUrl":"10.1016/j.spl.2025.110591","url":null,"abstract":"<div><div>Permutation-based partial-correlation tests guarantee finite-sample Type I error control under any fixed design and exchangeable noise, yet their power can collapse when the permutation-augmented design aligns too closely with the covariate of interest. We remedy this by fixing a design-driven subset of rows and permuting only the remainder. The fixed rows are chosen by a greedy algorithm that maximizes a lower bound on power. This strategy reduces covariate-permutation collinearity while preserving worst-case Type I error control. Simulations confirm that this refinement maintains nominal size and delivers substantial power gains over original unrestricted permutations, especially in high-collinearity regimes.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110591"},"PeriodicalIF":0.7,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Generalized Likelihood Ratio test for constancy in varying coefficient models with endogenous regressors 内源性回归变量变系数模型的广义似然比检验
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-20 DOI: 10.1016/j.spl.2025.110606
Luis A. Arteaga-Molina, Juan M. Rodriguez-Poo
This paper proposes a Generalized Likelihood Ratio test for assessing coefficient constancy in varying coefficient models with endogenous regressors. The test accommodates endogeneity through a nonparametric instrumental variables framework and is explicitly designed for time series data, allowing for serial dependence via mixing conditions.
本文提出了一种广义似然比检验来评估具有内生回归量的变系数模型的系数稳定性。该测试通过非参数工具变量框架适应内生性,并明确为时间序列数据设计,允许通过混合条件进行序列依赖。
{"title":"A Generalized Likelihood Ratio test for constancy in varying coefficient models with endogenous regressors","authors":"Luis A. Arteaga-Molina,&nbsp;Juan M. Rodriguez-Poo","doi":"10.1016/j.spl.2025.110606","DOIUrl":"10.1016/j.spl.2025.110606","url":null,"abstract":"<div><div>This paper proposes a Generalized Likelihood Ratio test for assessing coefficient constancy in varying coefficient models with endogenous regressors. The test accommodates endogeneity through a nonparametric instrumental variables framework and is explicitly designed for time series data, allowing for serial dependence via mixing conditions.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110606"},"PeriodicalIF":0.7,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptotic behavior of renewal processes with random time 随机时间更新过程的渐近行为
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-19 DOI: 10.1016/j.spl.2025.110603
Diana Rauwolf , Udo Kamps
For renewal processes with random time, extensions of well-known asymptotic relations such as the elementary renewal theorem, Blackwell’s renewal and Smith’s key renewal theorem are given. Whereas, in these results, time tends to infinity, the limits here are taken with respect to a sequence of parameters of respective random-time distributions satisfying some condition.
对于随机时间的更新过程,给出了众所周知的渐近关系如初等更新定理、Blackwell更新定理和Smith键更新定理的推广。然而,在这些结果中,时间趋于无穷,这里的极限是对满足某些条件的各自随机时间分布的参数序列取的。
{"title":"Asymptotic behavior of renewal processes with random time","authors":"Diana Rauwolf ,&nbsp;Udo Kamps","doi":"10.1016/j.spl.2025.110603","DOIUrl":"10.1016/j.spl.2025.110603","url":null,"abstract":"<div><div>For renewal processes with random time, extensions of well-known asymptotic relations such as the elementary renewal theorem, Blackwell’s renewal and Smith’s key renewal theorem are given. Whereas, in these results, time tends to infinity, the limits here are taken with respect to a sequence of parameters of respective random-time distributions satisfying some condition.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110603"},"PeriodicalIF":0.7,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Location tests with noisy proxies for latent variables 使用潜在变量的噪声代理进行定位测试
IF 0.7 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2025-11-17 DOI: 10.1016/j.spl.2025.110590
Louis Deutsch, Eugene Katsevich
We investigate inference in a latent binary variable model where a noisy proxy of the latent variable is available, motivated by the variable perturbation effectiveness problem in single-cell CRISPR screens. The baseline approach is to ignore the perturbation effectiveness problem, while a recent proposal employs a weighted average based on the proxies. Our main goals are to determine how accurate the proxies must be in order for a weighted test to gain power over the unweighted baseline, and to develop tests that are powerful regardless of the accuracy of the proxies. To address the first goal, we compute the Pitman relative efficiency of the weighted test relative to the unweighted test, yielding an interpretable quantification of proxy quality that drives the power of the weighted test. To address the second goal, we propose two strategies. First, we propose a maximum-likelihood based approach that adapts the proxies to the data. Second, we propose an estimator of the Pitman efficiency if a “positive control outcome variable” is available (as is often the case in single-cell CRISPR screens), which facilitates an adaptive choice of whether to use the proxies at all. Our numerical simulations support the Pitman efficiency as the key quantity for determining whether the weighted test gains power over the baseline, and demonstrate that the two proposed adaptive tests can improve on both existing approaches across a range of proxy qualities.
我们研究了潜在二元变量模型中的推理,其中潜在变量的噪声代理是可用的,这是由单细胞CRISPR屏幕中的可变扰动有效性问题驱动的。基线方法忽略了扰动有效性问题,而最近的一项建议采用基于代理的加权平均方法。我们的主要目标是确定代理必须有多准确,以便加权测试获得超过未加权基线的能力,并开发无论代理的准确性如何都强大的测试。为了解决第一个目标,我们计算了加权测试相对于未加权测试的Pitman相对效率,产生了驱动加权测试能力的代理质量的可解释量化。为实现第二个目标,我们提出两项战略。首先,我们提出了一种基于最大似然的方法,使代理适应数据。其次,如果存在“阳性控制结果变量”(如单细胞CRISPR筛选中经常出现的情况),我们提出皮特曼效率的估计,这有助于对是否使用代理进行自适应选择。我们的数值模拟支持Pitman效率作为确定加权测试是否优于基线的关键数量,并证明两种提出的自适应测试可以在代理质量范围内改进现有的两种方法。
{"title":"Location tests with noisy proxies for latent variables","authors":"Louis Deutsch,&nbsp;Eugene Katsevich","doi":"10.1016/j.spl.2025.110590","DOIUrl":"10.1016/j.spl.2025.110590","url":null,"abstract":"<div><div>We investigate inference in a latent binary variable model where a noisy proxy of the latent variable is available, motivated by the variable perturbation effectiveness problem in single-cell CRISPR screens. The baseline approach is to ignore the perturbation effectiveness problem, while a recent proposal employs a weighted average based on the proxies. Our main goals are to determine how accurate the proxies must be in order for a weighted test to gain power over the unweighted baseline, and to develop tests that are powerful regardless of the accuracy of the proxies. To address the first goal, we compute the Pitman relative efficiency of the weighted test relative to the unweighted test, yielding an interpretable quantification of proxy quality that drives the power of the weighted test. To address the second goal, we propose two strategies. First, we propose a maximum-likelihood based approach that adapts the proxies to the data. Second, we propose an estimator of the Pitman efficiency if a “positive control outcome variable” is available (as is often the case in single-cell CRISPR screens), which facilitates an adaptive choice of whether to use the proxies at all. Our numerical simulations support the Pitman efficiency as the key quantity for determining whether the weighted test gains power over the baseline, and demonstrate that the two proposed adaptive tests can improve on both existing approaches across a range of proxy qualities.</div></div>","PeriodicalId":49475,"journal":{"name":"Statistics & Probability Letters","volume":"230 ","pages":"Article 110590"},"PeriodicalIF":0.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Statistics & Probability Letters
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1