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The effects of ethyl pyruvate against experimentally induced cisplatin ototoxicity in rats. 丙酮酸乙酯对实验性大鼠顺铂耳毒性的影响。
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-12-01 Epub Date: 2021-10-12 DOI: 10.1080/08990220.2021.1984875
Muhammed Ayral, Serdar Ferit Toprak

Introduction: Cisplatin (CDDP) is a widely used antineoplastic drug. However, its use is limited due to the ototoxic side effects. In this study, the effects of ethyl pyruvate (EP), known for its antioxidant and anti-inflammatory effects, against CDDP ototoxicity were investigated.

Methods: Thirty-two Wistar albino rats (n:8) were used in this study. CDDP was administered i.p. as a single dose of 15 mg/kg/day in order to cause ototoxicity. EP was applied i.p. at a dose of 50 mg/kg/day for 7 days.

Results: When the Auditory Brainstem Responses (ABR) and Distortion Product Otoacoustic Emissions (DPOAE) tests carried out in the pre-treatment and post-treatment periods were examined, it was observed that the hearing functions were significantly impaired with the CDDP application, while a significant improvement was observed in the CDDP + EP group. Compared to the control group, the CDDP group had significantly higher malondialdehyde (MDA) levels and significantly lower glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) levels. In the CDDP + EP group, there was no deterioration in MDA, SOD and CAT levels that was observed in the CDDP group. The increase in pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) levels caused by CDDP administration was observed to be significantly decreased in the CDDP + EP group.

Conclusions: Hearing tests and biochemical results show that ethyl pyruvate is protective against cisplatin ototoxicity with its antioxidant and anti-inflammatory effects.

顺铂(CDDP)是一种应用广泛的抗肿瘤药物。然而,由于耳毒性副作用,其使用受到限制。本文研究了具有抗氧化和抗炎作用的丙酮酸乙酯(EP)对CDDP耳毒性的影响。方法:选用32只Wistar白化大鼠(8只)。CDDP单次给药15 mg/kg/d,以引起耳毒性。EP以50mg /kg/天的剂量ig,连用7天。结果:对治疗前后的听觉脑干反应(ABR)和畸变产物耳声发射(DPOAE)测试进行对比,发现CDDP组听力功能明显受损,而CDDP + EP组听力功能明显改善。与对照组相比,CDDP组丙二醛(MDA)水平显著升高,谷胱甘肽过氧化物酶(GPx)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)水平显著降低。在CDDP + EP组中,MDA、SOD和CAT水平未见CDDP组的下降。在CDDP + EP组中,CDDP引起的促炎细胞因子(IL-1β、IL-6和TNF-α)水平升高明显降低。结论:丙酮酸乙酯具有抗氧化和抗炎作用,对顺铂耳毒性具有保护作用。
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引用次数: 1
Visuospatial working memory abilities and spontaneous sensations perception. 视觉空间工作记忆能力和自发感觉知觉。
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-06-27 DOI: 10.1080/08990220.2021.1914018
Sara Salgues, Gaën Plancher, George A Michael

Aim: Body awareness arises when attending to and maintaining awareness of visuospatial body representations. By the same token, focussing on representations transfers them to working memory. Body awareness and working memory seemingly rely on similar processes and recruit common parietal areas involved in perception. Therefore, we asked whether visuospatial working memory abilities would define individual differences in the perception of spontaneous sensations (SPS), i.e., bodily sensations perceived in the absence of triggers (e.g., tactile stimulation or movement), when attending to the body.Method: Participants completed two visuospatial working memory tasks to assess various mechanisms: (i) the decay of representations was assessed through a Brown-Peterson task in which the delay between the memorandum presentation and its recall was manipulated, and (ii) the impact of distractors' interference and cognitive load (i.e., complexity) on recall performances were assessed through a complex span task that required the processing of distractors while maintaining a memorandum. A standard SPS task involving localization and characterization of SPS perceived on the hands was completed afterwards.Results: Low performance due to decay, distractors' interference and cognitive load in visuospatial working memory was associated with a decrease in the frequency of SPS. Additionally, low performance due to distractors' cognitive load predicted a decrease in the perception of surface-type sensations, and high performance despite distractors' interference led to a better perception of SPS on less sensitive areas of the hand.Conclusion: We discuss how visuospatial working memory processes might contribute to body awareness and perceptual distortions of the body.

目的:当注意和保持对视觉空间身体表征的意识时,身体意识就会产生。出于同样的原因,专注于表征会将它们转移到工作记忆中。身体意识和工作记忆似乎依赖于类似的过程,并涉及到与感知有关的共同顶叶区域。因此,我们询问视觉空间工作记忆能力是否会定义自发感觉(SPS)感知的个体差异,即,当关注身体时,在没有触发(如触觉刺激或运动)的情况下感知的身体感觉。方法:被试完成两个视觉空间工作记忆任务来评估不同的记忆机制:(i)通过Brown-Peterson任务来评估表征的衰退,在Brown-Peterson任务中,备忘录的呈现和回忆之间的延迟被操纵;(ii)通过一个复杂的跨任务来评估干扰物的干扰和认知负荷(即复杂性)对回忆表现的影响,该任务要求在保持备忘录的同时处理干扰物。随后完成一项标准的SPS任务,包括定位和表征手部感知到的SPS。结果:视觉空间工作记忆的衰退、干扰和认知负荷导致的表现低下与SPS频率降低有关。此外,由于干扰物的认知负荷导致的低表现预示着对表面类型感觉的感知下降,而尽管有干扰物的干扰,高表现导致对手部不敏感区域的SPS感知更好。结论:我们讨论了视觉空间工作记忆过程对身体意识和身体知觉扭曲的影响。
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引用次数: 2
Investigation of the relationship between physical activity, kinesiophobia and fear of falling in older adults with chronic pain. 老年慢性疼痛患者体力活动、运动恐惧症和跌倒恐惧之间关系的调查。
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-08-02 DOI: 10.1080/08990220.2021.1958774
Meral Sertel, Saniye Aydoğan Arslan, Eylem Tütün Yümin, Cevher Savcun Demirci, Tülay Tarsuslu Şimşek

Aims: This study aims to investigate the relationship between physical activity, fear of movement and fear of falling in older adults with chronic pain.

Materials and methods: The study includes 163 older adults aged 65 years and over, who live in a private nursing home. The cognitive functions of the individuals who participated in the study were evaluated with the mini-mental examination scale (MMES), fears of movement with the Tampa Scale of Kinesiophobia (TSK), fear-avoidance behaviour with the Fear-avoidance Beliefs Questionnaire (FABQ), physical activity levels with the Physical Activity Scale for Older (PASE), and the fears of falling were assessed with Tinetti's Falls Efficacy Scale (FES).

Results: In the correlation analysis, there was a weak correlation between age and fall risk (r = 0.349, p < 0.001), and PASETotal score (r = -0.020, p = 0.011). There was a weak positive correlation between Tinetti FES and FABQ scores (r = 0.349, p < 0.001), and kinesiophobia value (r = 0.259, p < 0.001), there was a weak negative correlation between Tinetti FES and PASETotal (r = -0.241, p = 0.002). A positive mid correlation was determined between kinesiophobia and the FABQ scores (r = 0.41, p < 0.001). The established regression model was found to be significant (F = 12.175; p < 0.001). Among the independent variables included in the model, FABQTotal (t = 3.589; p < 0.0001) and PASETotal (t = -3.325; p < 0.0001) significantly affected the fear of falling.

Conclusion: The presence of chronic pain in older adults who have problems related to physical activity, fear of falling, and kinesiophobia due to advancing age may affect social participation, functional level, and quality of life significantly. Therefore, pain should be addressed in older adults and should be considered as an important issue in rehabilitation programs.

目的:本研究旨在探讨慢性疼痛老年人身体活动、运动恐惧和跌倒恐惧之间的关系。材料和方法:研究对象为163名65岁及以上的老年人,他们住在一家私人养老院。采用迷你心理检查量表(MMES)、坦帕运动恐惧量表(TSK)、恐惧回避行为量表(FABQ)、老年人身体活动量表(PASE)和Tinetti跌倒效能量表(FES)评估受试者的认知功能。结果:在相关分析中,年龄与跌倒风险呈弱相关(r = 0.349, p)。总分(r = -0.020, p = 0.011)。Tinetti FES与FABQ评分呈弱正相关(r = 0.349, p r = 0.259, p Total (r = -0.241, p = 0.002)。运动恐惧症与FABQ评分呈正相关(r = 0.41, p F = 12.175;p Total (t = 3.589;p Total (t = -3.325;p结论:老年人慢性疼痛的存在与身体活动相关的问题,由于年龄的增长,害怕跌倒和运动恐惧症可能会显著影响社会参与,功能水平和生活质量。因此,疼痛应该在老年人中得到解决,并应被视为康复计划中的一个重要问题。
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引用次数: 10
Two-point discrimination assessment of the lower extremities of healthy young Turkish individuals. 健康年轻土耳其人下肢两点辨别评估
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-08-08 DOI: 10.1080/08990220.2021.1959310
Cem Erçalık, Seçil Özkurt

Objectives: To investigate the normative two-point discrimination (TPD) values of the lower extremities of healthy young Turkish individuals.

Patients and methods: Fifty-five healthy, young adults were recruited in this prospective study. Ten lower extremity parts were tested with esthesiometer: proximal thigh, midlateral thigh, midmedial thigh, midposterior thigh, proximal lateral leg, distal lateral leg, medial leg, the tip of great toe, skin over 1-2 metatarsal interspace, skin over 5th metatars at both dominant and non-dominant sides.

Results: There were 27 (49.1%) female and 28 (50.9%) male participants with a mean age of 22.06 ± 1.76 years. The reference values of the TPD of the lower extremities were between 42.4 ± 5.4 mm and 4.0 ± 1.3 mm by females and between 42.6 ± 6.4 mm and 4.4 ± 2.4 mm by males. Test values in the combined group of men and women were statistically greater at the dominant sides than the non-dominant sides at the following areas: proximal lateral leg (p = 0.01), distal lateral leg (p = 0.046), medial leg (p = 0.001), tip of great toe (p = 0.02), skin over 1-2 metatarsal interspace (p = 0.010), skin over 5th metatars (p = 0.002). There was no statistical difference in the test scores of men and women in any of the measured areas, with additional evaluation of both the dominant and the non-dominant sides (p > 0.05).

Conclusion: The results of the present study demonstrated that TPD ability varied in different skin areas within the same individual. We found that laterality, though with lower scores on the non-dominant side in some lower extremity parts, but not the gender had an effect on TPD.

目的:探讨土耳其健康青年下肢两点辨别(TPD)的标准值。患者和方法:在这项前瞻性研究中招募了55名健康的年轻人。用触感计测试10个下肢部位:大腿近端、大腿中外侧、大腿中外侧、大腿中外侧、大腿中外侧、小腿内侧、大脚趾尖、优势侧和非优势侧1-2跖间隙皮肤、第5跖皮肤。结果:女性27例(49.1%),男性28例(50.9%),平均年龄22.06±1.76岁。下肢TPD参考值女性为42.4±5.4 mm ~ 4.0±1.3 mm,男性为42.6±6.4 mm ~ 4.4±2.4 mm。联合组男性和女性优势侧的测试值在以下区域大于非优势侧:小腿近侧(p = 0.01)、小腿远侧(p = 0.046)、小腿内侧(p = 0.001)、大趾尖(p = 0.02)、1-2跖间隙皮肤(p = 0.010)、第5跖皮肤(p = 0.002)。男性和女性在任何测量区域的测试成绩均无统计学差异,并对优势侧和非优势侧进行了额外评估(p > 0.05)。结论:本研究结果表明,同一个体不同皮肤区域的TPD能力存在差异。我们发现,侧偏性虽然在某些下肢非优势侧得分较低,但性别对TPD没有影响。
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引用次数: 0
The characteristics, disabilities, and spinal alignment of women with double crush syndrome: a case-control study. 双重挤压综合征女性的特征、残疾和脊柱对齐:一项病例对照研究。
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-04-05 DOI: 10.1080/08990220.2021.1908250
Derya Ozer Kaya, Seyda Toprak Celenay, Senem Sas

Aims: Double crush syndrome is a clinical condition composed of neurological dysfunction due to compressive pathology at multiple sites along a single peripheral nerve. The aims were to investigate the characteristics and disabilities of women with double crush syndrome, to compare the spinal alignment to healthy women, and to determine the cut-offs for the spinal alignment characteristics.

Methods: Twenty women with double crush syndrome (age: 49.50 ± 8.64 years) and 21 asymptomatic healthy controls (age: 44.76 ± 7.82 years) were included in the study. The physical characteristics, pain intensity, and symptoms were questioned. Disability with Disability of Arm and Shoulder Questionnaire and Neck Disability Index and spinal alignment with Spinal Mouse® (Idiag, Fehraltorf, Switzerland) were assessed.

Results: The pain intensity at rest, night, and during activity was 3.70 ± 3.25, 6.01 ± 2.77, and 7.15 ± 2.68 cm, respectively. The most bothersome symptom was numbness (65%). The symptoms were seen in hands and/or fingers (55%), arms (15%), shoulder blade (15%), and neck (15%). The Disability of Arm and Shoulder Questionnaire and Neck Disability Index scores were 58.64 ± 15.41 and 19.55 ± 6.37, respectively. The sagittal thoracic curvature (p: .011) and lumbar curvature (p: .049) increased, and the overall spine mobility (p<.001) decreased in the double crush syndrome patients. The cut-off points were detected as 54.5° (area under the curve: 0.680, p: .049, 40% sensitivity, 99.9% specificity) for the thoracic spinal curvature, and 113.5° (area under the curve: 0.667, p<.000, 65% sensitivity, 99.9% specificity) for the overall spine mobility.

Conclusions: The double crush syndrome patients had moderate to severe pain and disability, increased thoracic and lumbar curvature, and decreased spine mobility. The cut-off values were found as 54.5° for thoracic curvature and 113.5° for spine mobility.

目的:双重挤压综合征是一种神经功能障碍的临床症状,由于压迫病理在多个部位沿单一周围神经。目的是调查双重挤压综合征女性的特征和残疾,将脊柱对齐与健康女性进行比较,并确定脊柱对齐特征的截止点。方法:选取20例双挤压综合征患者(年龄49.50±8.64岁)和21例无症状健康对照(年龄44.76±7.82岁)作为研究对象。对患者的身体特征、疼痛强度和症状进行了调查。使用spinal Mouse®(Idiag, Fehraltorf, Switzerland)对手臂和肩部残疾问卷、颈部残疾指数和脊柱对准进行评估。结果:休息、夜间、活动时疼痛强度分别为3.70±3.25 cm、6.01±2.77 cm、7.15±2.68 cm。最令人烦恼的症状是麻木(65%)。症状见于手和/或手指(55%)、手臂(15%)、肩胛骨(15%)和颈部(15%)。臂肩残疾问卷得分为58.64±15.41分,颈部残疾指数得分为19.55±6.37分。矢状胸椎曲度(p: 0.011)和腰椎曲度(p: 0.049)增加,胸椎曲度和113.5°(曲线下面积:0.667)的整体脊柱活动度(p: 0.049,敏感性40%,特异性99.9%)增加,结论:双挤压综合征患者有中重度疼痛和残疾,胸椎曲度和腰椎曲度增加,脊柱活动度降低。截断值为胸椎弯曲度54.5°,脊柱活动度113.5°。
{"title":"The characteristics, disabilities, and spinal alignment of women with double crush syndrome: a case-control study.","authors":"Derya Ozer Kaya,&nbsp;Seyda Toprak Celenay,&nbsp;Senem Sas","doi":"10.1080/08990220.2021.1908250","DOIUrl":"https://doi.org/10.1080/08990220.2021.1908250","url":null,"abstract":"<p><strong>Aims: </strong>Double crush syndrome is a clinical condition composed of neurological dysfunction due to compressive pathology at multiple sites along a single peripheral nerve. The aims were to investigate the characteristics and disabilities of women with double crush syndrome, to compare the spinal alignment to healthy women, and to determine the cut-offs for the spinal alignment characteristics.</p><p><strong>Methods: </strong>Twenty women with double crush syndrome (age: 49.50 ± 8.64 years) and 21 asymptomatic healthy controls (age: 44.76 ± 7.82 years) were included in the study. The physical characteristics, pain intensity, and symptoms were questioned. Disability with Disability of Arm and Shoulder Questionnaire and Neck Disability Index and spinal alignment with Spinal Mouse<sup>®</sup> (Idiag, Fehraltorf, Switzerland) were assessed.</p><p><strong>Results: </strong>The pain intensity at rest, night, and during activity was 3.70 ± 3.25, 6.01 ± 2.77, and 7.15 ± 2.68 cm, respectively. The most bothersome symptom was numbness (65%). The symptoms were seen in hands and/or fingers (55%), arms (15%), shoulder blade (15%), and neck (15%). The Disability of Arm and Shoulder Questionnaire and Neck Disability Index scores were 58.64 ± 15.41 and 19.55 ± 6.37, respectively. The sagittal thoracic curvature (<i>p</i>: .011) and lumbar curvature (<i>p</i>: .049) increased, and the overall spine mobility (<i>p</i><.001) decreased in the double crush syndrome patients. The cut-off points were detected as 54.5° (area under the curve: 0.680, <i>p</i>: .049, 40% sensitivity, 99.9% specificity) for the thoracic spinal curvature, and 113.5° (area under the curve: 0.667, <i>p</i><.000, 65% sensitivity, 99.9% specificity) for the overall spine mobility.</p><p><strong>Conclusions: </strong>The double crush syndrome patients had moderate to severe pain and disability, increased thoracic and lumbar curvature, and decreased spine mobility. The cut-off values were found as 54.5° for thoracic curvature and 113.5° for spine mobility.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"157-163"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08990220.2021.1908250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25560680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pilot trial of a mouthpiece as treatment for signs and symptoms of Parkinson disease. 用牙套治疗帕金森病的症状和体征的初步试验。
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-07-28 DOI: 10.1080/08990220.2021.1953462
David Scott May, Kerri Sharp Rawson, Donald Richard Moeller, Lauren Elizabeth Tueth, Gammon M Earhart

Purpose: Several case studies and anecdotal reports have shown assorted motor and quality of life benefits from use of a dental mouthpiece among people with Parkinson disease (PD). A larger exploratory study is necessary to assess potential efficacy and feasibility of this treatment strategy. If shown to be effective and feasible in a larger sample of people with PD, mechanistic studies may be warranted to examine a potential relationship between orofacial sensory input and motor function in people with PD.

Materials and methods: This study was registered on clinicaltrials.gov (NCT: 04082663). Twenty people with PD, Hoehn and Yahr stages I-III, participated in this study. Each participant completed various baseline motor and quality of life assessments before being fitted with a custom mouthpiece. Motor assessments were completed a second time after 25 min of mouthpiece wear. Participants were asked to wear the mouthpiece for 1 month before completing follow-up quality of life assessments and providing feedback about the mouthpiece. Wilcoxon signed-rank tests were used to compare results across conditions.

Results: Gait velocity and cadence showed significant (p < .05) improvement while wearing the mouthpiece. However, these changes were not significant after correcting for multiple comparisons. Thirteen participants indicated they would be unlikely to continue wearing the mouthpiece.

Conclusions: These results do not provide adequate evidence to pursue further this type of mouthpiece as a treatment strategy for motor signs and symptoms or quality of life in people with PD.

目的:几个案例研究和轶事报告显示,帕金森病(PD)患者使用牙套对运动和生活质量有各种好处。需要更大规模的探索性研究来评估这种治疗策略的潜在疗效和可行性。如果在更大的PD患者样本中被证明是有效和可行的,那么机制研究可能有必要检查PD患者口面部感觉输入和运动功能之间的潜在关系。材料和方法:本研究已在clinicaltrials.gov网站注册(NCT: 04082663)。20名PD患者,Hoehn和Yahr I-III期,参与了这项研究。每位参与者在佩戴定制的牙套之前完成了各种基线运动和生活质量评估。佩戴牙套25分钟后进行第二次运动评估。参与者被要求在完成后续生活质量评估并提供关于口腔套的反馈之前佩戴口腔套1个月。使用Wilcoxon符号秩检验来比较不同条件下的结果。结果:步态速度和节奏显示显著(p)结论:这些结果没有提供足够的证据来进一步研究这种类型的牙套作为PD患者运动体征和症状或生活质量的治疗策略。
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引用次数: 0
Effect of sensorimotor training on spatiotemporal parameters of gait among middle and older age adults with diabetic peripheral neuropathy. 感觉运动训练对中老年糖尿病周围神经病变患者步态时空参数的影响。
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-08-02 DOI: 10.1080/08990220.2021.1955671
Irshad Ahmad, Shalini Verma, Majumi Mohamad Noohu, Mohd Ejaz Hussain

Purpose: The study aimed to evaluate the effect of sensorimotor training on spatiotemporal parameters of gait among middle-aged and older adults with diabetic peripheral neuropathy (DPN).

Methods: A randomised controlled study with four parallel arms (two intervention groups and two control groups) was conducted. Thirty-seven DPN patients were selected on the basis of inclusion and exclusion criteria. Of these, 16 middle-aged and 21 older adults were randomly allocated to the intervention and control groups. Participants in the intervention group were administered eight weeks (three days/week) of sensorimotor training along with diabetes and foot care education whereas participants in the control group received only diabetes and foot care education. Outcome measures involved spatiotemporal parameters of gait at self-paced and maximal-paced, measured before and after eight weeks.

Results: Age difference was found to be significant in velocity (p ≤ 0.013) and stride length (p ≤ 0.017) at self-paced and maximal-paced walking. After the intervention, velocity was found to be a significant group effect and time × group interaction at self-paced (p = 0.003) and maximal-paced (p = 0.003) walking. Stride length (p = 0.006) was found to be a significant group effect and time × group interaction at self-paced only. Cadence (p = 0.041) and gait cycle (p = 0.05) were found to be significant time × group interaction only at maximal-paced walking. Stance (p ≤ 0.047) and double limb support (p ≤ 0.02) were found to be significant group effect and time × group interaction at self-paced and maximal-paced walking.

Conclusion: Sensorimotor training improves spatiotemporal parameters of gait after eight weeks in similar fashion in middle-aged and older age DPN patients, regardless of age.

目的:研究感觉运动训练对中老年糖尿病周围神经病变(DPN)患者步态时空参数的影响。方法:采用随机对照研究,4个平行臂(2个干预组和2个对照组)。根据纳入和排除标准选择37例DPN患者。其中,16名中年人和21名老年人被随机分配到干预组和对照组。干预组的参与者接受了8周(3天/周)的感觉运动训练,同时接受了糖尿病和足部护理教育,而对照组的参与者只接受了糖尿病和足部护理教育。结果测量包括在8周之前和之后测量的自步速和最大步速步态的时空参数。结果:自配步幅与最大配步幅在速度(p≤0.013)和步幅(p≤0.017)上存在显著的年龄差异。干预后,在自步速(p = 0.003)和最大步速(p = 0.003)步行中,速度是显著的组效应,时间×组交互作用显著。步幅长度(p = 0.006)在组间效应和时间×组间交互作用均显著。步幅(p = 0.041)和步态周期(p = 0.05)仅在最大步速步行时被发现具有显著的时间×组相互作用。站立(p≤0.047)和双肢支撑(p≤0.02)在自步速和最大步速行走中具有显著的组效应和时间×组交互作用。结论:感觉运动训练在8周后以相似的方式改善中老年DPN患者的步态时空参数,无论年龄大小。
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引用次数: 4
The effect of a textured insole on anticipatory postural adjustments. 质地鞋垫对预期姿势调整的影响。
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-05-24 DOI: 10.1080/08990220.2021.1918659
Etem Curuk, Alexander S Aruin

Purpose: To obtain preliminary data on the effect of a textured insole on postural control.

Methods: Nine healthy subjects were exposed to external perturbations applied to their shoulders while standing with or without a single textured insole. Body weight distribution and bilateral electromyographic activity (EMG) of trunk and leg muscles were recorded. Onsets of EMG activity of muscles were calculated and analyzed within the interval typical for anticipatory postural adjustments.

Results: When a textured insole was provided under one foot, subjects shifted their body weight towards the contralateral foot. With no insole, the anticipatory onsets of EMG activity of the left and right muscles were symmetrical; when a textured insole was used, the EMG onsets of the muscles on the contralateral side of the body were seen earlier as compared to the insole side. This early activation was more pronounced in the trunk muscles (p < 0.05).

Conclusions: Using a single textured insole under one-foot induced asymmetry of anticipatory onsets of EMG activity in healthy subjects. The outcome highlights the importance of investigating the role of a single textured insole in control of vertical posture and provides a foundation for future studies focussed on improvement of postural control in individuals with body asymmetry due to unilateral weakness.

目的:获得纹理鞋垫对姿势控制影响的初步数据。方法:9名健康受试者在穿着或不穿单一纹理鞋垫站立时暴露于施加于肩部的外部扰动。记录体重分布及躯干、腿部肌肉的双侧肌电活动。在预期体位调整的典型间隔内计算和分析肌肉肌电活动的发作。结果:当在一只脚下提供有纹理的鞋垫时,受试者将体重转移到对侧脚。无鞋垫时,左右肌肌电活动的预期发作是对称的;当使用有纹理的鞋垫时,与鞋垫一侧相比,身体对侧肌肉的肌电图发作时间更早。这种早期激活在躯干肌肉中更为明显(p)。结论:在健康受试者中,在单足下使用单一纹理鞋垫会导致肌电图活动的预期不对称。该结果强调了研究单一纹理鞋垫在控制垂直姿势中的作用的重要性,并为未来的研究提供了基础,重点是改善由于单侧虚弱而导致的身体不对称个体的姿势控制。
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引用次数: 3
Does somatosensory feedback from the plantar foot sole contribute to verticality perception? 来自足底的体感反馈是否有助于垂直感?
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-07-13 DOI: 10.1080/08990220.2021.1949977
A Nedelkou, V Hatzitaki, K Chatzinikolaou, G Grouios

Aim of the study: In upright standing, the human foot sole is the only point of contact with the ground conveying information about the pressure distribution under the feet. We examined how the altered somatosensory input from the plantar foot receptors, when standing on a soft surface, affects the subjective estimation of the earth vertical in different sensory contexts.

Materials and methods: Twelve (12) healthy young females (mean age: 21.8 ± 2.4 years) adjusted the orientation of a visual line (35 × 1.5 cm) representing the roll orientation of a hand-held (attached on a 24.9 × 4 cm cylinder) or head-attached electromagnetic tracking sensor (Nest of Birds, Ascension Technologies Inc., VT. USA, 60 Hz) under two visual conditions (eyes open, eyes closed) while standing on a soft or firm surface. The mean absolute (accuracy) and variable (precision) error in the verticality estimate was depicted in the sensor's roll deviation from the gravitational vertical.

Results: The accuracy and the precision of the estimate decreased in the absence of vision, while standing on the soft surface and when the estimate was provided by an active hand rather than head rotation. The surface effect was significant only in the absence of vision and when the estimate was provided by the hand.

Conclusions: The contribution of the plantar foot mechanoreceptors to gravity perception is sensory context dependent. Perception of the earth vertical is more accurate when estimated by active head rotation due to the integration of the vestibular and neck proprioceptive afferents.

研究的目的:在直立站立时,人的脚底是唯一与地面接触的点,传递有关脚底压力分布的信息。我们研究了当站在柔软的表面上时,来自足底感受器的体感输入是如何在不同的感觉环境中影响对地面垂直度的主观估计的。材料和方法:12(12)名健康的年轻女性(平均年龄:21.8±2.4岁)在两种视觉条件下(眼睛睁开和闭上),站在柔软或坚硬的表面上,调整代表手持式(附着在24.9 × 4 cm圆柱体上)或头戴式电磁跟踪传感器(Nest of Birds, Ascension Technologies Inc., VT. USA, 60 Hz)滚动方向的视觉线(35 × 1.5 cm)的方向。垂直度估计的平均绝对(精度)和变(精度)误差用传感器与重力垂直线的滚转偏差来描述。结果:在没有视觉的情况下,当站在柔软的表面上,当用手而不是头部旋转提供估计时,估计的准确性和精度下降。表面效应只有在没有视觉和用手进行估计时才显着。结论:足底机械感受器对重力感知的贡献是感觉环境依赖性的。由于前庭和颈部本体感觉传入的整合,当头部主动旋转时,对地球垂直的感知更准确。
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引用次数: 5
Characterization of stimulus response curves obtained with transcranial magnetic stimulation from bilateral anterior digastric muscles in healthy subjects. 健康受试者双侧前二腹肌经颅磁刺激获得的刺激反应曲线特征。
IF 0.9 4区 医学 Q4 NEUROSCIENCES Pub Date : 2021-09-01 Epub Date: 2021-06-14 DOI: 10.1080/08990220.2021.1914019
Paul Herbert, Jeanmarie R Burke

Purpose: The purpose of the study was to describe measurements of stimulus-response curves in the anterior digastric muscle (ADM) bilaterally following transcranial magnetic stimulation (TMS) to the right and left hemispheres. The first dorsal interosseous muscle (FDI) was the control muscle.

Materials and methods: The subjects were 20 healthy young adults. Test sessions determined motor thresholds (MT) and stimulus-response curves (1.0, 1.2, 1.4, 1.6 × MT) from either the FDI or ADM following TMS to left and right hemispheres using the double cone coil. Bilateral recordings of MEPs in the left and right ADM allowed us to generate stimulus response curves following ipsilateral and contralateral TMS.

Results: Intraclass correlation coefficients (ICC) for MEP amplitudes from ipsilateral and contralateral ADMs were >0.60 at motor threshold (MT) and >0.90 at stimulus intensities above MT. There was a linear increase in MEP amplitudes across stimulus intensities for the FDI following contralateral TMS, while MEP amplitudes from the ADM following contralateral and ipsilateral TMS increased linearly across stimulus intensities [F(3, 57) [Muscle × Recording Site × Stim Intensity] = 33.57; p < 0.05]; (ηp2 = 0.64). The slopes of the stimulus-response curve of the contralateral FDI was greater than the slopes of the stimulus response curves of the ipsilateral and contralateral ADM (p < 0.05).

Conclusions: The current study provided insights on the methodology for recording stimulus response curves in the ADM with TMS. These findings may translate into a valid, reliable, and relevant clinical outcome to study the pathophysiology of the corticobulbar motor system.

目的:本研究的目的是描述经颅磁刺激(TMS)左右脑半球后双侧前二腹肌(ADM)的刺激反应曲线的测量结果。第一背骨间肌(FDI)为控制肌。材料与方法:研究对象为20名健康青年。使用双锥体线圈测定经颅磁刺激后FDI或ADM到左右半球的运动阈值(MT)和刺激反应曲线(1.0、1.2、1.4、1.6 × MT)。在同侧和对侧经颅磁刺激后,左、右ADM的mep双侧记录使我们能够生成刺激反应曲线。结果:同侧和对侧ADMs MEP振幅的类内相关系数(ICC)在运动阈值(MT)下>0.60,在MT以上刺激强度下>0.90。对侧经颅磁刺激后FDI MEP振幅在不同刺激强度下呈线性增加,而对侧和同侧经颅磁刺激后ADM MEP振幅在不同刺激强度下呈线性增加[F(3,57)][肌肉×记录部位×刺激强度]= 33.57;P (ηp2 = 0.64)。对侧FDI的刺激-反应曲线斜率大于同侧和对侧ADM的刺激-反应曲线斜率(p)。结论:本研究对经颅磁刺激法记录ADM刺激反应曲线的方法提供了新的思路。这些发现可以转化为有效、可靠和相关的临床结果来研究皮质球运动系统的病理生理学。
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引用次数: 0
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Somatosensory and Motor Research
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