首页 > 最新文献

Sleep Medicine Reviews最新文献

英文 中文
Individualized approaches to pediatric chronic insomnia: Advancing precision medicine in sleep disorders 小儿慢性失眠症的个性化治疗方法:推进睡眠障碍的精准医疗
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-05-07 DOI: 10.1016/j.smrv.2024.101946
Oliviero Bruni , Marco Angriman , Silvia Miano , Lourdes M. DelRosso , Karen Spruyt , Maria P. Mogavero , Raffaele Ferri

The manifestations of chronic insomnia undergo age-related changes. In younger infants and children, behavioral insomnia emerges as the most prevalent form and typically responds to behavioral interventions. However, distinct clusters of clinical presentations suggest the presence of various phenotypes, potentially implicating the primary involvement of specific neurotransmitters. These conceptualizations, coupled with genetic studies on pleiotropy and polygenicity, may aid in identifying individuals at risk of persistent insomnia into adulthood and shed light on novel treatment options. In school-age children, the predominant presentation is sleep-onset insomnia, often linked with nighttime fears, anxiety symptoms, poor sleep hygiene, limit-setting issues, and inadequate sleep duration. The manifestations of insomnia in adolescence correlate with the profound changes occurring in sleep architecture, circadian rhythms, and homeostatic processes. The primary symptoms during adolescence include delayed sleep onset, sleep misperception, persistent negative thoughts about sleep, and physiological hyperarousal—paralleling features observed in adult insomnia. An approach centered on distinct presentations may provide a framework for precision-based treatment options. Enhanced comprehension of insomnia’s manifestations across diverse developmental stages can facilitate accurate assessment. Efforts to subtype insomnia in childhood align with this objective, potentially guiding the selection of appropriate treatments tailored to individual neurobiological, clinical, and familial features.

慢性失眠症的表现会随着年龄的变化而变化。在年龄较小的婴儿和儿童中,行为性失眠是最常见的表现形式,通常对行为干预措施有反应。然而,不同的临床表现群表明存在不同的表型,这可能与特定神经递质的主要参与有关。这些概念,再加上对多义性和多基因性的遗传研究,可能有助于识别成年后仍有持续失眠风险的个体,并揭示新的治疗方案。在学龄儿童中,主要表现为睡眠发作性失眠,通常与夜间恐惧、焦虑症状、睡眠不卫生、限制问题和睡眠时间不足有关。青春期失眠的表现与睡眠结构、昼夜节律和体内平衡过程发生的深刻变化有关。青春期的主要症状包括睡眠开始延迟、睡眠误解、对睡眠的持续消极想法以及生理过度焦虑--与成人失眠症的特征相似。以不同表现为中心的方法可为精确治疗方案提供一个框架。加强对失眠症在不同发育阶段表现形式的理解有助于进行准确的评估。对儿童失眠症进行亚型分类的努力与这一目标相一致,有可能指导人们根据个体的神经生物学、临床和家族特征选择适当的治疗方法。
{"title":"Individualized approaches to pediatric chronic insomnia: Advancing precision medicine in sleep disorders","authors":"Oliviero Bruni ,&nbsp;Marco Angriman ,&nbsp;Silvia Miano ,&nbsp;Lourdes M. DelRosso ,&nbsp;Karen Spruyt ,&nbsp;Maria P. Mogavero ,&nbsp;Raffaele Ferri","doi":"10.1016/j.smrv.2024.101946","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101946","url":null,"abstract":"<div><p>The manifestations of chronic insomnia undergo age-related changes. In younger infants and children, behavioral insomnia emerges as the most prevalent form and typically responds to behavioral interventions. However, distinct clusters of clinical presentations suggest the presence of various phenotypes, potentially implicating the primary involvement of specific neurotransmitters. These conceptualizations, coupled with genetic studies on pleiotropy and polygenicity, may aid in identifying individuals at risk of persistent insomnia into adulthood and shed light on novel treatment options. In school-age children, the predominant presentation is sleep-onset insomnia, often linked with nighttime fears, anxiety symptoms, poor sleep hygiene, limit-setting issues, and inadequate sleep duration. The manifestations of insomnia in adolescence correlate with the profound changes occurring in sleep architecture, circadian rhythms, and homeostatic processes. The primary symptoms during adolescence include delayed sleep onset, sleep misperception, persistent negative thoughts about sleep, and physiological hyperarousal—paralleling features observed in adult insomnia. An approach centered on distinct presentations may provide a framework for precision-based treatment options. Enhanced comprehension of insomnia’s manifestations across diverse developmental stages can facilitate accurate assessment. Efforts to subtype insomnia in childhood align with this objective, potentially guiding the selection of appropriate treatments tailored to individual neurobiological, clinical, and familial features.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101946"},"PeriodicalIF":10.5,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bright light therapy in cancer: Evidence for future research and therapy 癌症中的强光疗法:未来研究和治疗的证据
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-05-07 DOI: 10.1016/j.smrv.2024.101945
Nancy S. Redeker
{"title":"Bright light therapy in cancer: Evidence for future research and therapy","authors":"Nancy S. Redeker","doi":"10.1016/j.smrv.2024.101945","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101945","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101945"},"PeriodicalIF":10.5,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140906455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep assessment using EEG-based wearables – A systematic review 使用脑电图可穿戴设备进行睡眠评估 - 系统综述
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-05-07 DOI: 10.1016/j.smrv.2024.101951
C.J. de Gans , P. Burger , E.S. van den Ende , J. Hermanides , P.W.B. Nanayakkara , R.J.B.J. Gemke , F. Rutters , D.J. Stenvers

Polysomnography (PSG) is the reference standard of sleep measurement, but is burdensome for the participant and labor intensive. Affordable electroencephalography (EEG)-based wearables are easy to use and are gaining popularity, yet selecting the most suitable device is a challenge for clinicians and researchers. In this systematic review, we aim to provide a comprehensive overview of available EEG-based wearables to measure human sleep. For each wearable, an overview will be provided regarding validated population and reported measurement properties. A systematic search was conducted in the databases OVID MEDLINE, Embase.com and CINAHL. A machine learning algorithm (ASReview) was utilized to screen titles and abstracts for eligibility. In total, 60 papers were selected, covering 34 unique EEG-based wearables. Feasibility studies indicated good tolerance, high compliance, and success rates. The 42 included validation studies were conducted across diverse populations and showed consistently high accuracy in sleep staging detection. Therefore, the recent advancements in EEG-based wearables show great promise as alternative for PSG and for at-home sleep monitoring. Users should consider factors like user-friendliness, comfort, and costs, as these devices vary in features and pricing, impacting their suitability for individual needs.

多导睡眠图(PSG)是睡眠测量的参考标准,但对参与者来说是一种负担,而且需要大量人力。经济实惠的脑电图(EEG)可穿戴设备使用方便,越来越受到欢迎,但对于临床医生和研究人员来说,选择最合适的设备是一项挑战。在本系统综述中,我们旨在全面概述现有的基于脑电图的可穿戴设备,以测量人类睡眠。对于每种可穿戴设备,我们都将提供有关验证人群和报告测量特性的概述。我们在 OVID MEDLINE、Embase.com 和 CINAHL 数据库中进行了系统检索。利用机器学习算法(ASReview)筛选符合条件的标题和摘要。共筛选出 60 篇论文,涉及 34 种基于脑电图的可穿戴设备。可行性研究显示了良好的耐受性、较高的依从性和成功率。所纳入的 42 项验证研究针对不同人群进行,结果显示睡眠分期检测的准确性始终很高。因此,基于脑电图的可穿戴设备的最新进展显示出作为 PSG 和家庭睡眠监测的替代品的巨大前景。由于这些设备的功能和价格各不相同,影响了它们对个人需求的适用性,因此用户应考虑设备的易用性、舒适度和成本等因素。
{"title":"Sleep assessment using EEG-based wearables – A systematic review","authors":"C.J. de Gans ,&nbsp;P. Burger ,&nbsp;E.S. van den Ende ,&nbsp;J. Hermanides ,&nbsp;P.W.B. Nanayakkara ,&nbsp;R.J.B.J. Gemke ,&nbsp;F. Rutters ,&nbsp;D.J. Stenvers","doi":"10.1016/j.smrv.2024.101951","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101951","url":null,"abstract":"<div><p>Polysomnography (PSG) is the reference standard of sleep measurement, but is burdensome for the participant and labor intensive. Affordable electroencephalography (EEG)-based wearables are easy to use and are gaining popularity, yet selecting the most suitable device is a challenge for clinicians and researchers. In this systematic review, we aim to provide a comprehensive overview of available EEG-based wearables to measure human sleep. For each wearable, an overview will be provided regarding validated population and reported measurement properties. A systematic search was conducted in the databases OVID MEDLINE, Embase.com and CINAHL. A machine learning algorithm (ASReview) was utilized to screen titles and abstracts for eligibility. In total, 60 papers were selected, covering 34 unique EEG-based wearables. Feasibility studies indicated good tolerance, high compliance, and success rates. The 42 included validation studies were conducted across diverse populations and showed consistently high accuracy in sleep staging detection. Therefore<strong>,</strong> the recent advancements in EEG-based wearables show great promise as alternative for PSG and for at-home sleep monitoring. Users should consider factors like user-friendliness, comfort, and costs, as these devices vary in features and pricing, impacting their suitability for individual needs.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101951"},"PeriodicalIF":10.5,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000558/pdfft?md5=5757a5c8010e5bba8fe2f2b638b96be6&pid=1-s2.0-S1087079224000558-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory aspects of restless legs syndrome: Clinical, neurophysiological and neuroimaging prospectives 不宁腿综合征的感官方面:临床、神经生理学和神经影像学展望。
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-05-07 DOI: 10.1016/j.smrv.2024.101949
Elena Antelmi , Maria P. Mogavero , Giuseppe Lanza , Sandy M. Cartella , Luigi Ferini-Strambi , Giuseppe Plazzi , Raffaele Ferri , Michele Tinazzi

Restless Legs Syndrome (RLS) is a complex sensorimotor disorder, classified among the sleep-related movement disorders. Although sensory symptoms appear as key features of the disorder, they are still poorly characterized from a clinical perspective and conceptualized from a pathophysiological point of view. In this review, we aim to describe the clinical and functional substrates of RLS, focusing mainly on its sensory symptoms and on their neurophysiological and anatomical correlates. Knowledge of both subjective sensory symptoms and objective sensory signs are still controversial. Current data also indicate that the sensory component of RLS seems to be subserved by anomalies of sensorimotor integration and by mechanism of central sensitization. Overall, electrophysiological findings highlight the involvement of multiple generators in the pathogenesis of RLS, eventually resulting in an increased nervous system excitability and/or alterations in inhibition within the somatosensory and nociceptive pathways. Structural and functional neuroimaging data show the involvement of several crucial areas and circuits, among which the thalamus appears to play a pivotal role. A holistic approach looking at brain connectivity, structural or functional abnormalities, and their interplay with molecular vulnerability and neurotransmitter alterations is warranted to disentangle the complex framework of RLS.

不安腿综合征(RLS)是一种复杂的感觉运动障碍,属于睡眠相关运动障碍。虽然感觉症状是该疾病的主要特征,但从临床角度和病理生理学角度来看,这些症状的特征还很不明显。在这篇综述中,我们旨在描述 RLS 的临床和功能基础,主要侧重于其感觉症状及其神经生理学和解剖学相关性。关于主观感觉症状和客观感觉体征的知识仍存在争议。目前的数据还表明,RLS 的感觉症状似乎是由感觉运动整合异常和中枢敏感化机制引起的。总之,电生理学研究结果表明,RLS 的发病机制涉及多个发生器,最终导致神经系统兴奋性增高和/或躯体感觉和痛觉通路抑制的改变。结构和功能神经影像学数据显示,有几个关键区域和回路参与其中,其中丘脑似乎起着关键作用。我们有必要采用一种整体方法来研究大脑连接、结构或功能异常,以及它们与分子脆弱性和神经递质改变之间的相互作用,从而揭示 RLS 的复杂框架。
{"title":"Sensory aspects of restless legs syndrome: Clinical, neurophysiological and neuroimaging prospectives","authors":"Elena Antelmi ,&nbsp;Maria P. Mogavero ,&nbsp;Giuseppe Lanza ,&nbsp;Sandy M. Cartella ,&nbsp;Luigi Ferini-Strambi ,&nbsp;Giuseppe Plazzi ,&nbsp;Raffaele Ferri ,&nbsp;Michele Tinazzi","doi":"10.1016/j.smrv.2024.101949","DOIUrl":"10.1016/j.smrv.2024.101949","url":null,"abstract":"<div><p>Restless Legs Syndrome (RLS) is a complex sensorimotor disorder, classified among the sleep-related movement disorders. Although sensory symptoms appear as key features of the disorder, they are still poorly characterized from a clinical perspective and conceptualized from a pathophysiological point of view. In this review, we aim to describe the clinical and functional substrates of RLS, focusing mainly on its sensory symptoms and on their neurophysiological and anatomical correlates. Knowledge of both subjective sensory symptoms and objective sensory signs are still controversial. Current data also indicate that the sensory component of RLS seems to be subserved by anomalies of sensorimotor integration and by mechanism of central sensitization. Overall, electrophysiological findings highlight the involvement of multiple generators in the pathogenesis of RLS, eventually resulting in an increased nervous system excitability and/or alterations in inhibition within the somatosensory and nociceptive pathways. Structural and functional neuroimaging data show the involvement of several crucial areas and circuits, among which the thalamus appears to play a pivotal role. A holistic approach looking at brain connectivity, structural or functional abnormalities, and their interplay with molecular vulnerability and neurotransmitter alterations is warranted to disentangle the complex framework of RLS.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101949"},"PeriodicalIF":10.5,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lamentations in the night: A systematic review on catathrenia 黑夜中的哀歌catathrenia 系统综述
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-05-06 DOI: 10.1016/j.smrv.2024.101944
Quentin Martel , Jean-Baptiste Maranci , Carole Philippe , Isabelle Arnulf

Catathrenia is a loud expiratory moan during sleep that is a social embarrassment and is sometimes confused with central apnea on polysomnography. It affects about 4% of adults, but cases are rarely referred to sleep centers. Catathrenia affects males and females, children and adults, who are usually young and thin. A “typical” catathrenia begins with a deep inhalation, followed by a long, noisy exhalation, then a short, more pronounced exhalation, followed by another deep inhalation, often accompanied by arousal. The many harmonics of the sound indicate that it is produced by the vocal cords. It is often repeated in clusters, especially during REM sleep and at the end of the night. It does not disturb the sleepers, but their neighbors, and is associated with excessive daytime sleepiness in one-third of cases. The pathophysiology and treatment of typical catathrenia are still unknown. Later, a more atypical catathrenia was described, consisting of episodes of short (2 s), regular, semi-continuous expiratory moans during NREM sleep (mainly in stages N1 and N2) and REM sleep, often in people with mild upper airway obstruction. This atypical catathrenia is more commonly reduced by positive airway pressure and mandibular advancement devices that promote vertical opening.

Catathrenia 是一种睡眠时大声呼气的呻吟,会让人在社交场合感到尴尬,有时在多导睡眠图上会与中枢性呼吸暂停相混淆。约有 4% 的成年人患有这种疾病,但很少将病例转介到睡眠中心。卡他性睡眠呼吸暂停症影响男性和女性、儿童和成人,他们通常年轻而消瘦。典型的 "卡他性睡眠 "先是深吸气,然后是长而嘈杂的呼气,接着是短而更明显的呼气,然后是另一次深吸气,通常伴有唤醒。声音中的许多谐音表明它是由声带发出的。它经常成群重复出现,尤其是在快速动眼期睡眠和夜深人静时。它不会干扰睡眠者,但会干扰其周围的人,三分之一的病例与白天过度嗜睡有关。典型的脑供血不足的病理生理学和治疗方法尚不清楚。后来,有人描述了一种更不典型的催眠,即在快速眼动睡眠(主要是在 N1 和 N2 阶段)和快速眼动睡眠中出现短促(2 秒)、有规律、半持续的呼气呻吟,通常发生在有轻度上气道阻塞的人身上。气道正压和下颌前突装置可促进垂直开口,从而减少这种非典型呼气呻吟。
{"title":"Lamentations in the night: A systematic review on catathrenia","authors":"Quentin Martel ,&nbsp;Jean-Baptiste Maranci ,&nbsp;Carole Philippe ,&nbsp;Isabelle Arnulf","doi":"10.1016/j.smrv.2024.101944","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101944","url":null,"abstract":"<div><p>Catathrenia is a loud expiratory moan during sleep that is a social embarrassment and is sometimes confused with central apnea on polysomnography. It affects about 4% of adults, but cases are rarely referred to sleep centers. Catathrenia affects males and females, children and adults, who are usually young and thin. A “typical” catathrenia begins with a deep inhalation, followed by a long, noisy exhalation, then a short, more pronounced exhalation, followed by another deep inhalation, often accompanied by arousal. The many harmonics of the sound indicate that it is produced by the vocal cords. It is often repeated in clusters, especially during REM sleep and at the end of the night. It does not disturb the sleepers, but their neighbors, and is associated with excessive daytime sleepiness in one-third of cases. The pathophysiology and treatment of typical catathrenia are still unknown. Later, a more atypical catathrenia was described, consisting of episodes of short (2 s), regular, semi-continuous expiratory moans during NREM sleep (mainly in stages N1 and N2) and REM sleep, often in people with mild upper airway obstruction. This atypical catathrenia is more commonly reduced by positive airway pressure and mandibular advancement devices that promote vertical opening.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101944"},"PeriodicalIF":10.5,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140880088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep apnea and stroke: A dynamic duo 睡眠呼吸暂停与中风活力二重奏
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-05-01 DOI: 10.1016/j.smrv.2024.101943
Antonio Culebras
{"title":"Sleep apnea and stroke: A dynamic duo","authors":"Antonio Culebras","doi":"10.1016/j.smrv.2024.101943","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101943","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101943"},"PeriodicalIF":10.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review 评估针对阻塞性睡眠呼吸暂停患者白天过度嗜睡的药物治疗:综合网络荟萃分析和系统综述
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-04-30 DOI: 10.1016/j.smrv.2024.101934
Seyed Sina Neshat , Afshin Heidari , Mario Henriquez-Beltran , Kripa Patel , Brendon Colaco , Vichaya Arunthari , Alejandra Yu Lee Mateus , Joseph Cheung , Gonzalo Labarca

Obstructive sleep apnea (OSA) is associated with excessive daytime sleepiness (EDS). Pharmacotherapy offers a potential treatment approach for EDS in OSA patients. This systematic review and meta-analysis aimed to assess the efficacy and safety of pharmacological interventions for alleviating EDS in patients with OSA. Following PRISMA guidelines, we included randomized controlled trials investigating pharmacological treatments for EDS in adult OSA until August 2023. We conducted meta-analysis, subgroup, and meta-regression analyses using a random effects model. Finally, a network meta-analysis synthesized direct and indirect evidence, followed by a comprehensive safety analysis. We included 32 articles in the meta-analysis (n = 3357). Pharmacotherapy showed a significant improvement in the Epworth Sleepiness Scale (ESS) score (Mean Difference (MD) −2.73, (95 % Confidence Interval (CI) [−3.25, −2.20], p < 0.01) and Maintenance of Wakefulness Test (MWT) score (MD 6.00 (95 % CI [2.66, 9.33] p < 0.01). Solriamfetol, followed by Pitolisant and modafinil, exhibited the greatest ESS reduction, while Danavorexton, followed by Solriamfetol and MK-7288, had the strongest impact on MWT. MK-7288 had the most total adverse events (AEs), followed by Danavorexton and armodafinil. Pharmacological Interventions significantly alleviate EDS in OSA patients but with heterogeneity across medications. Treatment decisions should involve a personalized assessment of patient factors and desired outcomes.

阻塞性睡眠呼吸暂停(OSA)与白天过度嗜睡(EDS)有关。药物疗法是治疗 OSA 患者 EDS 的一种潜在方法。本系统综述和荟萃分析旨在评估药物干预对减轻 OSA 患者 EDS 的疗效和安全性。根据 PRISMA 指南,我们纳入了 2023 年 8 月之前调查成人 OSA EDS 药物治疗的随机对照试验。我们采用随机效应模型进行了荟萃分析、亚组分析和元回归分析。最后,网络荟萃分析综合了直接和间接证据,并进行了全面的安全性分析。我们在荟萃分析中纳入了 32 篇文章(n = 3357)。药物治疗可显著改善埃普沃思嗜睡量表(ESS)评分(平均差(MD)-2.73,(95 % 置信区间(CI)[-3.25,-2.20],p < 0.01)和保持清醒测试(MWT)评分(MD 6.00,(95 % CI [2.66,9.33] p < 0.01)。Solriamfetol 对ESS 的降低幅度最大,其次是 Pitolisant 和 modafinil,而 Danavorexton 对 MWT 的影响最大,其次是 Solriamfetol 和 MK-7288。MK-7288 的总不良事件(AEs)最多,其次是达那伐他汀和阿莫达非尼。药物干预能明显缓解 OSA 患者的 EDS,但不同药物之间存在差异。治疗决策应包括对患者因素和预期结果的个性化评估。
{"title":"Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review","authors":"Seyed Sina Neshat ,&nbsp;Afshin Heidari ,&nbsp;Mario Henriquez-Beltran ,&nbsp;Kripa Patel ,&nbsp;Brendon Colaco ,&nbsp;Vichaya Arunthari ,&nbsp;Alejandra Yu Lee Mateus ,&nbsp;Joseph Cheung ,&nbsp;Gonzalo Labarca","doi":"10.1016/j.smrv.2024.101934","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101934","url":null,"abstract":"<div><p>Obstructive sleep apnea (OSA) is associated with excessive daytime sleepiness (EDS). Pharmacotherapy offers a potential treatment approach for EDS in OSA patients. This systematic review and meta-analysis aimed to assess the efficacy and safety of pharmacological interventions for alleviating EDS in patients with OSA. Following PRISMA guidelines, we included randomized controlled trials investigating pharmacological treatments for EDS in adult OSA until August 2023. We conducted meta-analysis, subgroup, and meta-regression analyses using a random effects model. Finally, a network meta-analysis synthesized direct and indirect evidence, followed by a comprehensive safety analysis. We included 32 articles in the meta-analysis (n = 3357). Pharmacotherapy showed a significant improvement in the Epworth Sleepiness Scale (ESS) score (Mean Difference (MD) −2.73, (95 % Confidence Interval (CI) [−3.25, −2.20], p &lt; 0.01) and Maintenance of Wakefulness Test (MWT) score (MD 6.00 (95 % CI [2.66, 9.33] p &lt; 0.01). Solriamfetol, followed by Pitolisant and modafinil, exhibited the greatest ESS reduction, while Danavorexton, followed by Solriamfetol and MK-7288, had the strongest impact on MWT. MK-7288 had the most total adverse events (AEs), followed by Danavorexton and armodafinil. Pharmacological Interventions significantly alleviate EDS in OSA patients but with heterogeneity across medications. Treatment decisions should involve a personalized assessment of patient factors and desired outcomes.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101934"},"PeriodicalIF":10.5,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glimpsing tomorrow: Unveiling the prospective trajectory of childhood sleep 瞥见明天:揭示儿童睡眠的未来轨迹
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-04-27 DOI: 10.1016/j.smrv.2024.101941
Karen Spruyt (Prof. Dr.)
{"title":"Glimpsing tomorrow: Unveiling the prospective trajectory of childhood sleep","authors":"Karen Spruyt (Prof. Dr.)","doi":"10.1016/j.smrv.2024.101941","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101941","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101941"},"PeriodicalIF":10.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140823897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of sleep on oral health: A scoping review 睡眠对口腔健康的影响:范围审查
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-04-26 DOI: 10.1016/j.smrv.2024.101939
Jainy Shah, Brianna F. Poirier, Joanne Hedges, Lisa Jamieson, Sneha Sethi

Sleep is a vital biological process that facilitates numerous vital functions integral to mental and physical restoration of the body. Sleep deprivation or poor sleep quality not only affects physical health but may also affect oral health. This scoping review aims to collate existing evidence related to the impact of sleep duration and/or quality on oral health. A systematic search strategy using PubMed, Embase, Scopus and CINAHL databases was performed to identify studies that assessed the association between sleep quality or duration and oral health or hygiene. Two researchers independently screened and extracted the data. Eligible studies were critically appraised using the NIH quality assessment tool for observational cohort and cross-sectional studies checklist. The search identified 18,398 studies, from which 14 fulfilled the inclusion criteria. Of the 14 papers, four papers were associated with effect of sleep on caries, 8 papers described the effect of sleep on gingival and periodontal health, and two papers described the effect of sleep on general oral health and oral disease symptoms. This review found a direct link between sleep and dental decay in children, and short sleep duration was associated with an increased risk of periodontitis adults.

睡眠是一个重要的生物过程,它能促进人体精神和身体恢复所不可或缺的众多重要功能。睡眠不足或睡眠质量差不仅会影响身体健康,还可能影响口腔健康。本范围综述旨在整理与睡眠时间和/或质量对口腔健康的影响有关的现有证据。我们使用 PubMed、Embase、Scopus 和 CINAHL 数据库进行了系统性检索,以确定评估睡眠质量或持续时间与口腔健康或卫生之间关系的研究。两名研究人员独立筛选并提取数据。采用美国国立卫生研究院的观察性队列和横断面研究质量评估工具清单对符合条件的研究进行了严格评估。搜索共发现 18,398 项研究,其中 14 项符合纳入标准。在这 14 篇论文中,4 篇与睡眠对龋齿的影响有关,8 篇描述了睡眠对牙龈和牙周健康的影响,2 篇描述了睡眠对一般口腔健康和口腔疾病症状的影响。该综述发现,睡眠与儿童蛀牙之间存在直接联系,睡眠时间短与成人患牙周炎的风险增加有关。
{"title":"Effect of sleep on oral health: A scoping review","authors":"Jainy Shah,&nbsp;Brianna F. Poirier,&nbsp;Joanne Hedges,&nbsp;Lisa Jamieson,&nbsp;Sneha Sethi","doi":"10.1016/j.smrv.2024.101939","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101939","url":null,"abstract":"<div><p>Sleep is a vital biological process that facilitates numerous vital functions integral to mental and physical restoration of the body. Sleep deprivation or poor sleep quality not only affects physical health but may also affect oral health. This scoping review aims to collate existing evidence related to the impact of sleep duration and/or quality on oral health. A systematic search strategy using PubMed, Embase, Scopus and CINAHL databases was performed to identify studies that assessed the association between sleep quality or duration and oral health or hygiene. Two researchers independently screened and extracted the data. Eligible studies were critically appraised using the NIH quality assessment tool for observational cohort and cross-sectional studies checklist. The search identified 18,398 studies, from which 14 fulfilled the inclusion criteria. Of the 14 papers, four papers were associated with effect of sleep on caries, 8 papers described the effect of sleep on gingival and periodontal health, and two papers described the effect of sleep on general oral health and oral disease symptoms. This review found a direct link between sleep and dental decay in children, and short sleep duration was associated with an increased risk of periodontitis adults.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101939"},"PeriodicalIF":10.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000431/pdfft?md5=2c895651fe43f97159614db9198bfcac&pid=1-s2.0-S1087079224000431-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141084421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of one night of sleep restriction on sleepiness and cognitive function: A systematic review and meta-analysis 一夜睡眠限制对嗜睡和认知功能的影响:系统回顾和荟萃分析。
IF 10.5 1区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-04-26 DOI: 10.1016/j.smrv.2024.101940
Larissa N. Wüst , Noëmi C. Capdevila , Lina T. Lane , Carolin F. Reichert , Ruta Lasauskaite

Detrimental consequences of chronic sleep restriction on cognitive function are well established in the literature. However, effects of a single night of sleep restriction remain equivocal. Therefore, we synthesized data from 44 studies to investigate effects of sleep restriction to 2–6 h sleep opportunity on sleepiness and cognition in this meta-analysis. We investigated subjective sleepiness, sustained attention, choice reaction time, cognitive throughput, working memory, and inhibitory control. Results revealed a significant increase in subjective sleepiness following one night of sleep restriction (Standardized Mean Difference (SMD) = 0.986, p < 0.001), while subjective sleepiness was not associated with sleep duration during sleep restriction (β = −0.214, p = 0.039, significance level 0.01). Sustained attention, assessed via common 10-min tasks, was impaired, as demonstrated through increased reaction times (SMD = 0.512, p < 0.001) and attentional lapses (SMD = 0.489, p < 0.001). However, the degree of impaired attention was not associated with sleep duration (ps > 0.090). We did not find significant effects on choice reaction time, cognitive throughput, working memory, or inhibitory control. Overall, results suggest that a single night of restricted sleep can increase subjective sleepiness and impair sustained attention, a cognitive function crucial for everyday tasks such as driving.

长期限制睡眠对认知功能的有害影响已在文献中得到证实。然而,单晚睡眠限制的影响仍不明确。因此,我们综合了 44 项研究的数据,在这项荟萃分析中研究了将睡眠时间限制在 2-6 小时对嗜睡和认知的影响。我们调查了主观嗜睡、持续注意、选择反应时间、认知吞吐量、工作记忆和抑制控制。结果显示,在限制睡眠一晚后,主观嗜睡感会明显增加(标准化平均差 (SMD) = 0.986,P 0.090)。我们没有发现睡眠限制对选择反应时间、认知吞吐量、工作记忆或抑制控制有明显影响。总之,研究结果表明,一夜的睡眠限制会增加主观嗜睡感,并损害持续注意力,而持续注意力是对驾驶等日常任务至关重要的认知功能。
{"title":"Impact of one night of sleep restriction on sleepiness and cognitive function: A systematic review and meta-analysis","authors":"Larissa N. Wüst ,&nbsp;Noëmi C. Capdevila ,&nbsp;Lina T. Lane ,&nbsp;Carolin F. Reichert ,&nbsp;Ruta Lasauskaite","doi":"10.1016/j.smrv.2024.101940","DOIUrl":"10.1016/j.smrv.2024.101940","url":null,"abstract":"<div><p>Detrimental consequences of chronic sleep restriction on cognitive function are well established in the literature. However, effects of a single night of sleep restriction remain equivocal. Therefore, we synthesized data from 44 studies to investigate effects of sleep restriction to 2–6 h sleep opportunity on sleepiness and cognition in this meta-analysis. We investigated subjective sleepiness, sustained attention, choice reaction time, cognitive throughput, working memory, and inhibitory control. Results revealed a significant increase in subjective sleepiness following one night of sleep restriction (<em>Standardized Mean Difference</em> (<em>SMD</em>) = 0.986, <em>p</em> &lt; 0.001), while subjective sleepiness was not associated with sleep duration during sleep restriction (<em>β</em> = −0.214, <em>p</em> = 0.039, significance level 0.01). Sustained attention, assessed via common 10-min tasks, was impaired, as demonstrated through increased reaction times (<em>SMD</em> = 0.512, <em>p</em> &lt; 0.001) and attentional lapses (<em>SMD</em> = 0.489, <em>p</em> &lt; 0.001). However, the degree of impaired attention was not associated with sleep duration (<em>p</em>s &gt; 0.090). We did not find significant effects on choice reaction time, cognitive throughput, working memory, or inhibitory control. Overall, results suggest that a single night of restricted sleep can increase subjective sleepiness and impair sustained attention, a cognitive function crucial for everyday tasks such as driving.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101940"},"PeriodicalIF":10.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000443/pdfft?md5=62c60552bbf84456bcea4bf9d623a05a&pid=1-s2.0-S1087079224000443-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Sleep Medicine Reviews
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1