Sleep Medicine Reviews最新文献_第4页

Does short- and long-term exposure to air pollution affect the risk of obstructive sleep apnea? A systematic review and meta-analysis 短期和长期暴露在空气污染中会影响阻塞性睡眠呼吸暂停的风险吗？系统回顾和荟萃分析

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.smrv.2025.102225

Yansu He , Shuting Wang , Tianhang Zhang , Yuxuan Gu , Zuyao Yang , Linying Wu , Kin Fai Ho

The contribution of air pollution to obstructive sleep apnea (OSA) remains unclear. This systematic review and meta-analysis evaluated the impact of air pollution across different exposure windows on OSA and examined effect modifiers. Pubmed, Web of Science, and Embase were searched from inception to September 2024. Meta-analyses synthesized risk estimates using fixed- or random-effects models with I² heterogeneity assessment. Certainty of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. Of 5196 potential papers, 20 studies were included, with 13 eligible for meta-analysis. High-certainty evidence indicated that each 10 μg/m³ increase in short- and long-term PM_2.5 exposure was associated with a 2.25 % (95 % CI: 1.10 to 3.41) and 13.33 % (95 % CI: 9.85 to 16.80) increase in apnea-hypopnea index (AHI), respectively. For NO₂, each 10 ppb increase in short- and long-term exposure was associated with a 2.92 % (95 % CI: 1.29 to 4.54) and 8.93 % (95 % CI: 2.06 to 15.79) increase in AHI, with high- and moderate-certainty evidence, respectively. Medium-term PM_2.5 and NO₂ exposure were also associated with AHI, although with low certainty. No significant associations were observed for PM₁₀ and O₃. Exposure to PM_2.5 and NO₂, but not PM₁₀ or O₃, was associated with OSA severity.

空气污染对阻塞性睡眠呼吸暂停（OSA）的影响尚不清楚。本系统综述和荟萃分析评估了不同暴露窗口的空气污染对OSA的影响，并检查了影响调节剂。Pubmed， Web of Science和Embase从成立到2024年9月进行了搜索。荟萃分析使用固定或随机效应模型综合风险估计，并进行I2异质性评估。证据的确定性采用GRADE（建议评估、发展和评价分级）方法进行评估。在5196篇潜在论文中，纳入了20篇研究，其中13篇符合meta分析的条件。高确定性证据表明，短期和长期PM2.5暴露每增加10 μg/m3，呼吸暂停低通气指数（AHI）分别增加2.25% （95% CI: 1.10至3.41）和13.33% （95% CI: 9.85至16.80）。对于二氧化氮，短期和长期暴露每增加10 ppb， AHI分别增加2.92% （95% CI: 1.29至4.54）和8.93% (95% CI: 2.06至15.79)，具有高确定性和中等确定性的证据。中期PM2.5和NO2暴露也与AHI相关，尽管确定性较低。PM10和O3没有明显的相关性。暴露于PM2.5和NO2，而不是PM10或O3，与OSA严重程度相关。

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引用次数: 0

Post-stroke sleep disordered breathing and the effect of positive airway pressure treatment: An updated systematic review and meta-analysis of randomized control trials 卒中后睡眠呼吸障碍和气道正压治疗的效果：随机对照试验的最新系统综述和荟萃分析

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2025-11-22 DOI: 10.1016/j.smrv.2025.102207

Fotios Sampsonas , Vasileios Karamouzos , Michael Doulberis , Kyriakos Karkoulias , Dimosthenis Lykouras , Paschalis Steiropoulos , Argyrios Tzouvelekis

Obstructive sleep apnea is under-diagnosed, under-reported and therefore under-treated in patients after a stroke. The aim of this meta-analysis of Randomized Control Trials (RCTs) was to investigate the effectiveness of positive airway treatment on recurrent vascular events, neurological deficit, functional independence, depression, sleepiness and cognitive function in patients post-stroke.

Records identified from Embase Elsevier Database (Embase, Medline/PubMed, Preprints, PubMed-not-Medline) were searched from inception in July 2024, up to September 2024. After screening 72387 records, 21 RCTs were included with 1457 patients with stroke. Out of these 753 patients were in the PAP arm and 704 in the conventional arm.

Metanalysis showed that PAP treatment reduced recurrent vascular events OR 0.45, (95 % Confidence Interval (CI) 0.28 to 0.78; p < 0.01), improved neurological deficit OR -0.30, (95 % CI -0.47 to −0.14; p < 0.01), reduced daytime sleepiness OR: −0.96, (95 % CI -1.47 to −0.45; p < 0.01), improved depression levels; OR: −0.58, (95 % CI -1.05 to −0.11; p = 0.02), improved cognitive function; OR1.10; (95 % CI 0.35 to 1.86; p = 0.02), but did not improve functional independence OR 0.25, (95 % CI -0.11 to 0.60; p = 0.17)

Therefore, positive airway pressure treatment is effective in patients with stroke and can reduce recurrent vascular events and improve recovery of these patients.

阻塞性睡眠呼吸暂停在中风后的患者中诊断、报告不足，因此治疗不足。这项随机对照试验（RCTs）的荟萃分析的目的是研究正气道治疗对卒中后血管事件复发、神经功能缺损、功能独立、抑郁、嗜睡和认知功能的有效性。从Embase爱思唯尔数据库（Embase, Medline/PubMed, Preprints, PubMed-not-Medline）中识别的记录从2024年7月到2024年9月进行检索。在筛选72387份记录后，纳入21项随机对照试验，纳入1457例脑卒中患者。其中753名患者在PAP组，704名患者在常规组。荟萃分析显示PAP治疗减少血管复发事件OR 0.45,(95%可信区间（CI） 0.28 ~ 0.78；p < 0.01)，改善神经功能缺损OR -0.30, (95% CI -0.47至- 0.14;p < 0.01)，减少白天嗜睡OR: - 0.96, (95% CI -1.47至- 0.45;p < 0.01)，改善抑郁水平；OR: - 0.58, (95% CI -1.05 ~ - 0.11; p = 0.02)，认知功能改善；OR1.10;（95% CI 0.35 ~ 1.86; p = 0.02），但未改善功能独立性OR 0.25, （95% CI -0.11 ~ 0.60; p = 0.17）因此，气道正压治疗对脑卒中患者有效，可减少血管事件复发，提高患者康复。

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引用次数: 0

Time to take the Declaration of Helsinki seriously? A systematic review of comparison conditions in clinical trials on internet-delivered cognitive behavioral therapy for insomnia 是时候认真对待《赫尔辛基宣言》了？网络认知行为治疗失眠症临床试验比较条件的系统回顾

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.smrv.2025.102224

Lorenz Grolig , Hanna Brückner , Hannah Heimes , Claudia Buntrock , Christin Hempeler , Kai Spiegelhalder , Dirk Lehr

The Declaration of Helsinki (DoH) provides guidance on the choice of comparators in clinical trials, stating that new treatments must be compared against the best proven treatment. This systematic review examines whether research on a new treatment – internet-delivered cognitive behavioral therapy for insomnia (iCBT-I) – has adhered to these DoH requirements. A systematic literature search for randomized controlled trials (RCTs) testing iCBT-I in clinical samples was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. To identify the gold standard treatment, national guidelines were analyzed for all countries where published research on iCBT-I had been conducted.

After screening, 32 RCTs and seven guidelines for 12 countries were included. Almost all guidelines recommend face-to-face CBT-I as the gold standard, but only four (12.5 %) of the RCTs used this gold standard as a comparator. None of the other trials explained why they did not follow the DoH's recommendation.

The majority of clinical trials did not compare iCBT-I against the gold standard. As the DoH is intended to guide clinical research ethics, this low level of adherence is remarkable, and it raises uncertainty for patients, therapists, and policymakers about the effectiveness of iCBT-I compared to the gold standard treatment.

《赫尔辛基宣言》（DoH）为临床试验中比较物的选择提供了指导，指出必须将新治疗方法与已证实的最佳治疗方法进行比较。这篇系统综述研究了一种新的治疗方法——互联网传递的失眠认知行为疗法（iCBT-I）——是否符合这些DoH要求。按照系统评价和荟萃分析的首选报告项目（PRISMA）指南，对临床样本中检测iCBT-I的随机对照试验（rct）进行了系统文献检索。为了确定金标准治疗，对已发表icbt - 1研究的所有国家的国家指南进行了分析。筛选后，纳入了12个国家的32项随机对照试验和7项指南。几乎所有的指南都推荐面对面的CBT-I作为金标准，但只有四个（12.5%）的随机对照试验使用这一金标准作为比较。其他试验都没有解释为什么他们没有遵循卫生部的建议。大多数临床试验没有将iCBT-I与黄金标准进行比较。由于DoH旨在指导临床研究伦理，这种低水平的依从性是值得注意的，它给患者、治疗师和政策制定者带来了与金标准治疗相比iCBT-I有效性的不确定性。

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引用次数: 0

Letter to the editor: Higher risk evidence underlying claims of therapist-delivered CBT-I superiority 致编辑的信：高风险证据支持治疗师提供的CBT-I优势

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2026-01-21 DOI: 10.1016/j.smrv.2026.102234

Christopher B. Miller , Ian Wood , Colin A. Espie

引用次数: 0

Unravelling the association between sleep traits and reproductive cancers: A systematic review and meta-analysis 揭示睡眠特征与生殖癌症之间的关系：一项系统回顾和荟萃分析。

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2026-01-13 DOI: 10.1016/j.smrv.2026.102235

Eirini Pagkalidou , Christos K. Papagiannopoulos , Maria Manou , Panagiotis Filis , Rebecca C. Richmond , Konstantinos K. Tsilidis , Georgios Markozannes , Christos V. Chalitsios

Sleep traits (duration, insomnia, chronotype, snoring) are modifiable lifestyle factors that may influence cancer risk, but their association with reproductive cancers remains unclear. We systematically searched PubMed, Scopus, and Web of Science (until 09/2024) for observational studies investigating associations between sleep traits and reproductive cancers (including breast, prostate, endometrial, epithelial ovarian). We extracted estimates from maximally adjusted models and performed random-effects and dose-response meta-analyses. This study included 62 observational studies (45 cohort, 17 case-control) from 55 publications, but cohorts were primarily considered in interpretation. Compared to a morning chronotype, evening chronotype was associated with higher risk of breast cancer (HR = 1.12; 95 %CI: 1.07–1.17; I² = 14 %; 4 cohorts) and epithelial ovarian cancer (HR = 1.15; 95 %CI: 1.02–1.29; I² = 0 %; 2 cohorts). Insomnia was associated with elevated breast cancer risk (RR = 1.23; 95 %CI: 1.01–1.50; I² = 94 %; 9 cohorts), and the association remained similar for diagnosed insomnia (RR = 1.26; 95 %CI: 1.01–1.58; I² = 96 %; 5 studies), but high between-study heterogeneity was observed and the association was lost in properly adjusted studies (RR = 1.04; 95 %CI: 0.95–1.14; I² = 41.5 %; 3 cohorts). These findings support a role for circadian disruption in carcinogenesis. Future research should use objective sleep assessments and evaluate whether modifying sleep behaviours or circadian alignment can reduce cancer risk.

睡眠特征（持续时间、失眠、睡眠类型、打鼾）是可改变的生活方式因素，可能会影响癌症风险，但它们与生殖癌症的关系尚不清楚。我们系统地检索了PubMed、Scopus和Web of Science（截至2024年9月），以调查睡眠特征与生殖癌症（包括乳腺癌、前列腺癌、子宫内膜癌、卵巢上皮癌）之间关系的观察性研究。我们从最大调整模型中提取估计，并进行随机效应和剂量-反应荟萃分析。本研究包括来自55篇出版物的62项观察性研究（45项队列研究，17项病例对照研究），但在解释时主要考虑队列研究。与早晨睡眠类型的人相比，晚上睡眠类型的人患乳腺癌（HR = 1.12; 95% CI: 1.07-1.17; I2 = 14%； 4个队列）和上皮性卵巢癌（HR = 1.15; 95% CI: 1.02-1.29; I2 = 0%； 2个队列）的风险更高。失眠与乳腺癌风险升高相关（RR = 1.23; 95% CI: 1.01-1.50; I2 = 94%； 9个队列），诊断为失眠的患者与失眠之间的关联相似（RR = 1.26; 95% CI: 1.01-1.58; I2 = 96%； 5项研究），但研究间存在较高的异质性，在适当调整的研究中，这种关联消失（RR = 1.04; 95% CI: 0.95-1.14; I2 = 41.5%； 3个队列）。这些发现支持了昼夜节律紊乱在癌变中的作用。未来的研究应该使用客观的睡眠评估，并评估改变睡眠行为或昼夜节律是否可以降低癌症风险。

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引用次数: 0

Network models of subjective sleep health: a systematic review and statistical evaluation 主观睡眠健康的网络模型：系统回顾和统计评价

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2026-01-15 DOI: 10.1016/j.smrv.2026.102233

Meng-Yi Chen , Hua-Qing Xing , Qian-Hua Huang , Yuan Feng , Qinge Zhang , Ping Fan , Han-Xi Chen , Matteo Malgaroli , Todd Jackson , Gang Wang , Yu-Tao Xiang

Background

Given the increased use of network analysis in sleep studies, this systematic review and statistical evaluation aimed to aggregate network studies to identify the most central symptoms in composite network models of sleep-related symptoms.

Methods

A systematic search of cross-sectional network studies focused exclusively on sleep within community or clinical samples was conducted across PubMed, Web of Science (WOS), PsycINFO, and EMBASE databases up to March 5, 2025. Studies were categorized by topic and measurement instruments. Statistical evaluations extracted the most central symptoms across network models.

Results

The review included 23 studies of 84,510 participants and 29 network models. Explored topics included insomnia/sleep disturbances, sleep quality, sleep attitudes and behaviors, daytime function, and dream content. Regarding main analyses, key central symptoms in network models of insomnia were “Difficulty staying asleep” [median rank:1.5, Interquartile range (IQR): 1–2], “Distress caused by the sleep difficulties” (median rank:2, IQR: 2–3) and “Interference with daytime functioning” (median rank:3.5, IQR: 2.25–4). For sleep quality, “Subjective sleep quality” (median rank:1, IQR: 1-1), “Daytime dysfunction” (median rank:3, IQR: 2–5.25) and “Sleep disturbance” (median rank:3.5, IQR: 2–4.5) were the most central experiences.

Conclusions

Identified central symptoms offer plausible targets for intervention across populations and guide future research directions.

鉴于网络分析在睡眠研究中的应用越来越多，本系统综述和统计评估旨在汇总网络研究，以确定睡眠相关症状的复合网络模型中最核心的症状。方法系统检索截至2025年3月5日，在PubMed、Web of Science （WOS）、PsycINFO和EMBASE数据库中专门针对社区或临床样本中睡眠的横断面网络研究。研究按主题和测量工具分类。统计评估在网络模型中提取了最核心的症状。结果共纳入23项研究，84510名参与者，29个网络模型。研究的主题包括失眠/睡眠障碍、睡眠质量、睡眠态度和行为、白天功能和梦境内容。主要分析方面，失眠网络模型的主要中心症状为“难以入睡”（中位数秩：1.5，四分位差（IQR）： 1-2）、“睡眠困难引起的焦虑”（中位数秩：2，IQR: 2 - 3）和“干扰白天功能”（中位数秩：3.5,IQR: 2.25-4）。在睡眠质量方面，“主观睡眠质量”（中位数排名：1，IQR: 1-1）、“白天功能障碍”（中位数排名：3，IQR: 2-5.25）和“睡眠障碍”（中位数排名：3.5,IQR: 2-4.5）是最核心的体验。结论确定的中心症状为跨人群干预提供了合理的目标，并指导了未来的研究方向。

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引用次数: 0

Beyond the pulse and the pressure: human intelligence in the age of algorithmic Sleep Medicine 超越脉搏和压力：算法睡眠医学时代的人类智能

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2026-01-20 DOI: 10.1016/j.smrv.2026.102238

Monica Levy Andersen PhD (Editor in Chief of Sleep Medicine Reviews)

引用次数: 0

Unpacking sleep and mental health disparities across childhood and adolescence: A meta-analytic and systematic review 儿童期和青春期的睡眠和心理健康差异：一项荟萃分析和系统回顾

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2025-11-22 DOI: 10.1016/j.smrv.2025.102206

Morgan J. Thompson , Alexandra D. Ehrhardt , Ekjyot K. Saini , Emily F. Brigham , Zeynep Su Altinoz , Tiffany Yip , Joseph A. Buckhalt , Mona El-Sheikh

Children and adolescents from racial and ethnic minority and socioeconomically disadvantaged backgrounds are at greater risk for health disparities. This meta-analysis examined the association between sleep and mental health, with attention to variations by: (a) race, ethnicity, and socioeconomic status, and (b) individual sleep parameters and mental health domains. The review included 104 studies (66 independent samples, 326,478 participants). Less optimal sleep was associated with worse mental health (r = −.20, 95% CI [–.23, −.16]). Subjective sleep quality was a stronger correlate of mental health relative to all other sleep parameters (bs ranged from .11 to .19, ps < .001). Sleep schedule was a stronger correlate than objective sleep duration and quality (bs = .08 and .07, respectively, ps < .01). Sleep consistency was also a stronger correlate than objective sleep duration (b = .05, p = .03). Socioeconomic status moderated two associations. Objective sleep quality was more strongly linked to mental health among middle- relative to mixed-SES samples (b = .11, p = .01). Sleep consistency was more strongly associated with mental health among low- compared to mixed-SES samples (b = .05, p = .002). Findings are discussed in the context of methodological challenges in studying health disparities.

来自种族和族裔少数群体和社会经济不利背景的儿童和青少年面临更大的健康差异风险。这项荟萃分析考察了睡眠和心理健康之间的关系，并注意到：(a)种族、民族和社会经济地位的差异，以及(b)个体睡眠参数和心理健康领域的差异。该综述包括104项研究（66个独立样本，326,478名参与者）。较差的最佳睡眠与较差的心理健康相关（r = -）。20, 95% ci[-]。23日,−16])。相对于所有其他睡眠参数，主观睡眠质量与心理健康的相关性更强。11 . to…19, ps < .001)。睡眠计划与客观睡眠时间和质量的相关性更强(bs = .08和。分别为（p < .01）。睡眠一致性也比客观睡眠时间更强（b = 0.05, p = 0.03）。社会经济地位调节了这两种关联。目的：相对于混合ses样本，中等ses样本的睡眠质量与心理健康的关系更强（b = .11, p = .01）。与混合ses相比，低ses样本的睡眠一致性与心理健康的关系更强（b = 0.05, p = 0.002）。在研究健康差异的方法挑战的背景下讨论了研究结果。

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引用次数: 0

Advances in sleep research based on the Caenorhabditis elegans: an intestinal microbiota perspective and cutting-edge technology applications 基于秀丽隐杆线虫的睡眠研究进展：肠道微生物群视角和前沿技术应用

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2026-01-13 DOI: 10.1016/j.smrv.2026.102229

Wan-Qi Zhang , Xiao-Lin Li , Rui-Peng Xu , Yu-Long Li , Peng-Fei Hu , Ka-Hing Wong , Zhong-Yang Lin , Qiong-Qiong Yang , Bo-Bo Zhang

Sleep disorders affect approximately 27 % of the global population, driving non-pharmacological research on gut-brain axis regulation. Understanding sleep mechanisms is crucial, given its profound impact on health and disease. Caenorhabditis elegans (C. elegans) offers a powerful model for dissecting fundamental sleep processes, owing to its compact and fully mapped nervous system, genetic tractability, and suitability for high-throughput screening. This review leverages C. elegans integrated with gene editing, high-throughput behavioral phenotyping, and calcium imaging to dissect gut microbiota's role in sleep modulation. We explore how microbial metabolites regulate sleep via gut-brain pathways and summarize conserved sleep-related molecular mechanisms. The purpose of this review is to decode gut-brain-sleep axis interactions, offering novel mechanistic insights into sleep disorder pathophysiology.

睡眠障碍影响了全球约27%的人口，推动了肠-脑轴调节的非药物研究。考虑到睡眠对健康和疾病的深远影响，了解睡眠机制是至关重要的。秀丽隐杆线虫（秀丽隐杆线虫）提供了一个强大的模型，解剖基本的睡眠过程，由于其紧凑和完全映射的神经系统，遗传易感，适合高通量筛选。本综述利用秀丽隐杆线虫整合基因编辑、高通量行为表型和钙成像来解剖肠道微生物群在睡眠调节中的作用。我们探索微生物代谢物如何通过肠-脑通路调节睡眠，并总结保守的睡眠相关分子机制。本综述的目的是解码肠-脑-睡眠轴的相互作用，为睡眠障碍的病理生理学提供新的机制见解。

引用次数: 0

Hypnosis as therapy for non-REM parasomnia: A literature review 催眠治疗非快速眼动睡眠异常：文献综述

IF 9.7 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews

Pub Date : 2026-02-01 Epub Date: 2025-12-18 DOI: 10.1016/j.smrv.2025.102227

Geoffroy Solelhac , Nina Rimorini , Chantal Berna , Francesca Siclari

This systematic review provides an overview of the use of medical hypnosis for non-rapid eye movement parasomnias. It aims to describe the hypnotic inductions and suggestions applied in this context and assess their reported effectiveness. From a total of 427 articles identified through a comprehensive search of major medical databases, 24 studies met inclusion criteria. The majority were individual case reports or small case series, with only one study using a controlled design. Across these studies, 348 individuals with non-rapid eye movement parasomnias were described, with 148 receiving treatments with hypnosis. A positive clinical response was reported in approximately 82.6 % of these treated cases. However, the overall quality of evidence was low, with most studies offering limited methodological robustness and lacking standardized outcome measures. The hypnotic induction and suggestion techniques varied widely, yet general suggestions aimed at improving sleep quality were more frequently reported than specific ones targeting parasomnia features. Nevertheless, the more specific suggestions seemed to have better outcomes. This review suggests that hypnosis could be a promising therapeutic option. However, further, well-designed trials are required, including objective outcome evaluation, and standardized, targeted hypnotic approaches developed collaboratively between sleep and hypnosis specialists.

这篇系统的综述提供了对非快速眼动异动症使用医学催眠的概述。它的目的是描述催眠诱导和建议应用在这种情况下，并评估其报告的有效性。通过对主要医学数据库的全面检索，从总共427篇文章中确定，24项研究符合纳入标准。大多数是个案报告或小病例系列，只有一项研究采用对照设计。在这些研究中，348名非快速眼动异动症患者被描述，其中148人接受了催眠治疗。据报道，这些治疗病例中约有82.6%的临床反应为阳性。然而，证据的总体质量较低，大多数研究提供有限的方法稳健性，缺乏标准化的结果测量。催眠诱导和暗示技术差异很大，但旨在改善睡眠质量的一般建议比针对睡眠异常特征的特定建议更频繁地被报道。然而，更具体的建议似乎有更好的结果。这篇综述表明，催眠可能是一种很有前途的治疗选择。然而，进一步需要精心设计的试验，包括客观的结果评估，以及由睡眠和催眠专家合作开发的标准化、有针对性的催眠方法。

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引用次数: 0