Sleep Medicine Reviews最新文献

{"title":"Insomnia among hospitalized inpatients: A systematic review and network meta-analysis","authors":"Dario Bottignole ,&nbsp;Giulia Balella ,&nbsp;Matteo Minetti ,&nbsp;Luca Gambolò ,&nbsp;Francesco Rausa ,&nbsp;Giorgio Ughetti ,&nbsp;Andrea Melpignano ,&nbsp;Marcello Giuseppe Maggio ,&nbsp;Liborio Parrino ,&nbsp;Carlotta Mutti","doi":"10.1016/j.smrv.2025.102210","DOIUrl":"10.1016/j.smrv.2025.102210","url":null,"abstract":"<div><div>Insomnia affects up to 50% of hospitalized patients and is strongly associated with longer hospital stays and higher mortality rates, especially among vulnerable individuals. Despite its prevalence, it's often overlooked in clinical practice and research. Our systematic review analyzed and compared pharmacological interventions for insomnia in hospitalized patients. We searched five major databases for randomized controlled trials published before January 2024. A total of 29 trials (1913 patients, mean age 58.4 ± 9.66) were finally included. Different drug classes were evaluated, including benzodiazepines, Z-drugs, melatonin receptor agonists, antidepressants, antihistamines, alpha-2 adrenergic agonists, and dietary supplements. We conducted a network meta-analysis on drugs' efficacy across subjective sleep quality, sleep latency, total sleep duration, and nocturnal awakenings. Notably, only a minority of studies focused on fragile populations, such as geriatric and critically ill patients. Results are also discussed according to potential moderating factors (i.e., gender, age, admission setting). Our review provides a framework for the pharmacologic treatment of insomnia disorder in inpatients. Differences in study methodologies limit the generalizability of findings, highlighting the urgent need for standardized research to fill existing gaps. We therefore propose a concise protocol to guide the design of future studies on this clinically important topic.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102210"},"PeriodicalIF":9.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing strategies to address the global burden of insomnia","authors":"Adam V. Benjafield ,&nbsp;Emerson M. Wickwire","doi":"10.1016/j.smrv.2025.102209","DOIUrl":"10.1016/j.smrv.2025.102209","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102209"},"PeriodicalIF":9.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145584160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, cognition, and electrophysiology: Intersecting pathways in childhood cancer","authors":"Andrea Sanchez-Corzo ,&nbsp;Zachary Loschinskey ,&nbsp;Miguel Navarrete ,&nbsp;Catalina A. Saini Ferron ,&nbsp;Pankaj Pandey ,&nbsp;Jesyin Lai ,&nbsp;Belinda N. Mandrell ,&nbsp;Zachary R. Abramson ,&nbsp;Valerie McLaughlin Crabtree ,&nbsp;Ranganatha Sitaram","doi":"10.1016/j.smrv.2025.102205","DOIUrl":"10.1016/j.smrv.2025.102205","url":null,"abstract":"<div><div>Survivors of pediatric cancer are at high risk of long-term cognitive dysfunction. This problem is exacerbated as this population often reports poor sleep quality, which can negatively affect well-being. Sleep-related brain activity is known to influence cognitive development by regulating memory consolidation and cognitive functioning. However, the differences in sleep-related brain activity between healthy controls and pediatric cancer survivors are unclear. This review examines how sleep disturbances and cognitive impairments converge in survivors of childhood cancer, and proposes electrophysiology as a possible mechanistic bridge between these domains. We synthesize what is known from the general population and pediatric samples, highlight the critical need to investigate electrophysiological anomalies in pediatric cancer survivors, and suggest that neuromodulation techniques such as transcranial direct stimulation, transcranial magnetic stimulation, and sensory stimulation may be viable therapeutic interventions to enhance both sleep quality and cognitive function once possible anomalies are characterized in this population. Our review emphasizes the need for additional research to understand the complex relationship between sleep and cognition in pediatric cancer survivors to improve patient care and quality of life.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102205"},"PeriodicalIF":9.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to commentary on “Sleep abnormalities in mouse models of depression: a systematic review”","authors":"Alberto Potenzieri ,&nbsp;Andrea Escelsior ,&nbsp;Gianluca Serafini ,&nbsp;Antonio Uccelli ,&nbsp;Antoine Adamantidis ,&nbsp;Lino Nobili","doi":"10.1016/j.smrv.2025.102208","DOIUrl":"10.1016/j.smrv.2025.102208","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102208"},"PeriodicalIF":9.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-stroke sleep disordered breathing and the effect of positive airway pressure treatment: An updated systematic review and meta-analysis of randomized control trials","authors":"Fotios Sampsonas ,&nbsp;Vasileios Karamouzos ,&nbsp;Michael Doulberis ,&nbsp;Kyriakos Karkoulias ,&nbsp;Dimosthenis Lykouras ,&nbsp;Paschalis Steiropoulos ,&nbsp;Argyrios Tzouvelekis","doi":"10.1016/j.smrv.2025.102207","DOIUrl":"10.1016/j.smrv.2025.102207","url":null,"abstract":"<div><div>Obstructive sleep apnea is under-diagnosed, under-reported and therefore under-treated in patients after a stroke. The aim of this meta-analysis of Randomized Control Trials (RCTs) was to investigate the effectiveness of positive airway treatment on recurrent vascular events, neurological deficit, functional independence, depression, sleepiness and cognitive function in patients post-stroke.</div><div>Records identified from Embase Elsevier Database (Embase, Medline/PubMed, Preprints, PubMed-not-Medline) were searched from inception in July 2024, up to September 2024. After screening 72387 records, 21 RCTs were included with 1457 patients with stroke. Out of these 753 patients were in the PAP arm and 704 in the conventional arm.</div><div>Metanalysis showed that PAP treatment reduced recurrent vascular events OR 0.45, (95 % Confidence Interval (CI) 0.28 to 0.78; p &lt; 0.01), improved neurological deficit OR -0.30, (95 % CI -0.47 to −0.14; p &lt; 0.01), reduced daytime sleepiness OR: −0.96, (95 % CI -1.47 to −0.45; p &lt; 0.01), improved depression levels; OR: −0.58, (95 % CI -1.05 to −0.11; p = 0.02), improved cognitive function; OR1.10; (95 % CI 0.35 to 1.86; p = 0.02), but did not improve functional independence OR 0.25, (95 % CI -0.11 to 0.60; p = 0.17)</div><div>Therefore, positive airway pressure treatment is effective in patients with stroke and can reduce recurrent vascular events and improve recovery of these patients.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102207"},"PeriodicalIF":9.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145584159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unpacking sleep and mental health disparities across childhood and adolescence: A meta-analytic and systematic review","authors":"Morgan J. Thompson ,&nbsp;Alexandra D. Ehrhardt ,&nbsp;Ekjyot K. Saini ,&nbsp;Emily F. Brigham ,&nbsp;Zeynep Su Altinoz ,&nbsp;Tiffany Yip ,&nbsp;Joseph A. Buckhalt ,&nbsp;Mona El-Sheikh","doi":"10.1016/j.smrv.2025.102206","DOIUrl":"10.1016/j.smrv.2025.102206","url":null,"abstract":"<div><div>Children and adolescents from racial and ethnic minority and socioeconomically disadvantaged backgrounds are at greater risk for health disparities. This meta-analysis examined the association between sleep and mental health, with attention to variations by: (a) race, ethnicity, and socioeconomic status, and (b) individual sleep parameters and mental health domains. The review included 104 studies (66 independent samples, 326,478 participants). Less optimal sleep was associated with worse mental health (<em>r</em> = −.20, 95% CI [–.23, −.16]). Subjective sleep quality was a stronger correlate of mental health relative to all other sleep parameters (<em>b</em>s ranged from .11 to .19, <em>p</em>s &lt; .001). Sleep schedule was a stronger correlate than objective sleep duration and quality (<em>b</em>s = .08 and .07, respectively, <em>p</em>s &lt; .01). Sleep consistency was also a stronger correlate than objective sleep duration (<em>b</em> = .05, <em>p</em> = .03). Socioeconomic status moderated two associations. Objective sleep quality was more strongly linked to mental health among middle- relative to mixed-SES samples (<em>b</em> = .11, <em>p</em> = .01). Sleep consistency was more strongly associated with mental health among low- compared to mixed-SES samples (<em>b</em> = .05, <em>p</em> = .002). Findings are discussed in the context of methodological challenges in studying health disparities.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102206"},"PeriodicalIF":9.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep regularity as an important component of sleep hygiene: a systematic review","authors":"Alexandros Kalkanis ,&nbsp;Dierik Lenkens ,&nbsp;Paschalis Steiropoulos ,&nbsp;Dries Testelmans","doi":"10.1016/j.smrv.2025.102203","DOIUrl":"10.1016/j.smrv.2025.102203","url":null,"abstract":"<div><h3>Background</h3><div>Beyond sleep duration and efficiency, the day-to-day regularity of bed- and wake-times is increasingly recognized as a distinct dimension of sleep health. Whether irregular schedules independently predict adverse health outcomes remains unclear.</div></div><div><h3>Objective</h3><div>To synthesize evidence on the association between objectively or diary-quantified sleep regularity and mental, cardiometabolic, inflammatory, cognitive, lifestyle, sleep-disorder, and mortality outcomes in adults.</div></div><div><h3>Methods</h3><div>A protocol registered with PROSPERO (CRD420251101936) guided the review. MEDLINE (PubMed), Cochrane Library, PsycINFO, and Google Scholar were searched from inception to July 1, 2025 using a comprehensive strategy incorporating validated regularity metrics (Sleep Regularity Index, interdaily stability, composite phase deviation, social jetlag, night-to-night standard deviations). After duplicate removal, 3140 unique records underwent title/abstract screening; 147 full texts were reviewed. Risk of bias was appraised with the Newcastle–Ottawa Scale. Heterogeneity of metrics and outcomes precluded meta-analysis; evidence was synthesized narratively following SWiM guidelines and graded with van Tulder's best-evidence taxonomy.</div></div><div><h3>Results</h3><div>Fifty-nine primary studies met all criteria. Consistent, moderate-certainty evidence linked greater sleep-timing irregularity to higher depressive and anxiety symptoms, elevated body mass index, insulin resistance, hypertension, and incident cardiovascular events. Limited but directionally uniform evidence indicated higher inflammatory markers and poorer lifestyle indices in irregular sleepers. Prospective biobank data associated low Sleep Regularity Index with smaller hippocampal volume and a 26–53 % increase in dementia risk. Five low-bias cohorts showed 20–88 % higher all-cause mortality for the least regular sleepers, independent of sleep duration and quality. Mechanistic pathways implicated circadian misalignment, autonomic imbalance, and systemic inflammation.</div></div><div><h3>Conclusions</h3><div>Across diverse populations and measurement approaches, unstable sleep timing consistently portends poorer mental, metabolic, vascular, cognitive, and survival outcomes. Because sleep regularity is modifiable and objectively trackable with wearables, schedule stabilization merits elevation to a core public-health recommendation and a priority target for randomized intervention trials.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102203"},"PeriodicalIF":9.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission, treatment response, and treatment adherence across the delivery methods of cognitive behavioral therapy for insomnia: A systematic review and meta-analysis of randomized controlled trials","authors":"Yuta Takano ,&nbsp;Isa Okajima ,&nbsp;Masumi Osao ,&nbsp;Rui Ibata ,&nbsp;Naho Machida ,&nbsp;Koyo Higami ,&nbsp;Shunsuke Takagi ,&nbsp;Yuichi Inoue","doi":"10.1016/j.smrv.2025.102204","DOIUrl":"10.1016/j.smrv.2025.102204","url":null,"abstract":"<div><div>This study aimed to clarify the clinically meaningful outcomes and treatment adherence across different delivery methods of cognitive behavioral therapy for insomnia (CBT-I). CBT-I was defined as incorporating both sleep restriction and stimulus control techniques. This study included individual, group, fully automated Internet-based, and supported Internet-based formats. Remission from insomnia increased significantly across all delivery methods compared with the control group (individual: <em>k</em> = 36, <em>n</em> = 1696, odds ratio [OR] = 8.36; group: <em>k</em> = 22, <em>n</em> = 2356, OR = 4.65; fully automated Internet-based: <em>k</em> = 50, <em>n</em> = 15590, OR = 3.87; supported Internet-based: <em>k</em> = 19, <em>n</em> = 1759, OR = 8.35). After adjusting for comorbidities and types of control group, meta-regression analysis showed that the individual and supported Internet-based formats were significantly associated with higher odds of remission from insomnia compared with the fully automated Internet-based format. The completion rate for all sessions was significantly higher in the individual format (<em>k</em> = 8, 83.8%) than in the Internet-based formats (supported Internet-based: <em>k</em> = 15, 70.7%; fully automated Internet-based: <em>k</em> = 26, 58.4%). CBT-I is robustly effective in managing insomnia, although relatively lower treatment adherence continues to be a major challenge for Internet-based CBT-I.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102204"},"PeriodicalIF":9.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corpus callosum agenesis: does sleep matter?","authors":"Ludovica Pasca ,&nbsp;Helene Vitali ,&nbsp;Sara Uccella ,&nbsp;Carlo Alberto Quaranta ,&nbsp;Lia Macina ,&nbsp;Lynn K. Paul ,&nbsp;Valentina De Giorgis ,&nbsp;Valentina Franco ,&nbsp;Renato Borgatti ,&nbsp;Romina Romaniello","doi":"10.1016/j.smrv.2025.102202","DOIUrl":"10.1016/j.smrv.2025.102202","url":null,"abstract":"<div><div>Agenesis of the corpus callosum is a brain malformation that can lead to intellectual, behavioural, social and emotional impairments, with outcomes varying based on severity. Sleep disturbances are common in children with this disorder, and some studies have evidenced the role of corpus callosum in interhemispheric synchronisation that may influence sleep patterns. This narrative review attempted to intercept available information on sleep in patients with isolated Agenesis of the corpus callosum, partial and complete, across different ages. Since literature about this issue is underdeveloped, knowledge on callostomized individuals has been included. Corpus callosum disruption is linked to sleep disturbances, especially in early life, though the corpus callosum specific contribution remains unclear. Studies on callostomized individuals suggest that the corpus callosum plays a role in slow-wave transmission across hemispheres, which may affect sleep architecture and plasticity. The impaired transfer of brain activity between the hemispheres also seems to influence their dream experiences. The discussion pointed out that sleep problems in patients with Agenesis of the corpus callosum should be systematically assessed, as they may impact neurodevelopment and overall well-being, highlighting the need for further research and sleep interventions.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102202"},"PeriodicalIF":9.7,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guest editorial: Obstructive sleep apnea, cellular senescence, and aging: A convergence of pathways driving cardiometabolic risk","authors":"Yunzhou Dong,&nbsp;Virend K. Somers","doi":"10.1016/j.smrv.2025.102201","DOIUrl":"10.1016/j.smrv.2025.102201","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102201"},"PeriodicalIF":9.7,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}