Pub Date : 2024-10-01Epub Date: 2024-10-15DOI: 10.1055/s-0044-1788580
Antonio Di Donna, Salvatore Masala, Gianluca Muto, Stefano Marcia, Flavio Giordano, Mario Muto
Metabolic bone diseases (MBDs), including osteoporosis, osteomalacia, and Paget's disease, represent a significant challenge in medical imaging and intervention. Interventional radiologists play a pivotal role in managing these conditions, due to the crucial role of detailed and precise imaging in diagnosing and treating MBDs. This article offers comprehensive recommendations aimed at optimizing interventional radiologic practices for patients with MBDs, highlighting the importance of using advanced imaging modalities, including dual-energy X-ray absorptiometry and magnetic resonance imaging, essential for accurate assessment of bone mineral density and architecture, guiding effective intervention strategies. We also discuss the use of minimally invasive procedures like vertebroplasty and biopsy, vital for both diagnostic and therapeutic purposes, to enhance diagnostic accuracy and therapeutic outcomes, ensuring high-quality patient management in the context of MBDs.
代谢性骨病(MBDs),包括骨质疏松症、骨软化症和帕吉特氏病,是医学影像和介入治疗的重大挑战。由于详细而精确的成像在诊断和治疗代谢性骨病方面起着至关重要的作用,因此介入放射科医生在管理这些疾病方面发挥着举足轻重的作用。本文提出了旨在优化 MBD 患者介入放射疗法的全面建议,强调了使用先进成像模式(包括双能 X 射线吸收测量法和磁共振成像)的重要性,这对于准确评估骨矿物质密度和结构、指导有效的介入策略至关重要。我们还讨论了微创手术(如椎体成形术和活检)的使用,这对诊断和治疗都至关重要,可提高诊断准确性和治疗效果,确保对 MBD 患者进行高质量的管理。
{"title":"Metabolic Bone Diseases: Recommendations for Interventional Radiology.","authors":"Antonio Di Donna, Salvatore Masala, Gianluca Muto, Stefano Marcia, Flavio Giordano, Mario Muto","doi":"10.1055/s-0044-1788580","DOIUrl":"https://doi.org/10.1055/s-0044-1788580","url":null,"abstract":"<p><p>Metabolic bone diseases (MBDs), including osteoporosis, osteomalacia, and Paget's disease, represent a significant challenge in medical imaging and intervention. Interventional radiologists play a pivotal role in managing these conditions, due to the crucial role of detailed and precise imaging in diagnosing and treating MBDs. This article offers comprehensive recommendations aimed at optimizing interventional radiologic practices for patients with MBDs, highlighting the importance of using advanced imaging modalities, including dual-energy X-ray absorptiometry and magnetic resonance imaging, essential for accurate assessment of bone mineral density and architecture, guiding effective intervention strategies. We also discuss the use of minimally invasive procedures like vertebroplasty and biopsy, vital for both diagnostic and therapeutic purposes, to enhance diagnostic accuracy and therapeutic outcomes, ensuring high-quality patient management in the context of MBDs.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 5","pages":"641-650"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-10-15DOI: 10.1055/s-0044-1789256
Alberto Bazzocchi, Giuseppe Guglielmi
{"title":"Imaging of Metabolic Bone Diseases.","authors":"Alberto Bazzocchi, Giuseppe Guglielmi","doi":"10.1055/s-0044-1789256","DOIUrl":"10.1055/s-0044-1789256","url":null,"abstract":"","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 5","pages":"513-514"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-10-15DOI: 10.1055/s-0044-1788885
Rossella Gifuni, Manuela Montatore, Riccardo Guglielmi, Alberto Bazzocchi, Carmelo Messina, Giuseppe Guglielmi
Dual-energy X-ray absorptiometry (DXA) and bone mineral density (BMD) pose several limitations in some patient categories, such as pregnant women and young people. This review article explores whether the innovative radiofrequency echographic multi-spectrometry (REMS) technology is beneficial for assessing the bone condition of various patient groups. Common consequences in patients with acromegalia, prostate cancer undergoing hormone therapy, osteogenesis imperfecta, anorexia nervosa, and in a peritoneal dialysis setting include decreased BMD and an increased risk of fragility fracture.DXA is currently regarded as the gold standard for BMD assessment. However, using the DXA technique has several drawbacks in a young patient who requires repeated BMD tests because it uses ionizing radiation. Because of its precision and consistency, the REMS technique may be a valuable tool to assess changes in bone condition in patients of all ages, particularly in female patients who are fertile or who are pregnant or nursing.
双能 X 射线吸收测量法(DXA)和骨矿物质密度(BMD)在某些患者类别中存在一些局限性,如孕妇和年轻人。这篇综述文章探讨了创新的射频回声多谱勒技术(REMS)是否有利于评估不同患者群体的骨质状况。肢端肥大症患者、接受激素治疗的前列腺癌患者、成骨不全症患者、神经性厌食症患者以及腹膜透析患者的常见后果包括 BMD 减少和脆性骨折风险增加。然而,对于需要反复进行 BMD 测试的年轻患者来说,使用 DXA 技术有几个缺点,因为它使用了电离辐射。由于其精确性和一致性,REMS 技术可能是评估各年龄段患者骨质状况变化的重要工具,尤其是对生育期、妊娠期或哺乳期的女性患者。
{"title":"Radiofrequency Echographic Multi-Spectrometry in the Diagnosis of Metabolic Bone Disease.","authors":"Rossella Gifuni, Manuela Montatore, Riccardo Guglielmi, Alberto Bazzocchi, Carmelo Messina, Giuseppe Guglielmi","doi":"10.1055/s-0044-1788885","DOIUrl":"https://doi.org/10.1055/s-0044-1788885","url":null,"abstract":"<p><p>Dual-energy X-ray absorptiometry (DXA) and bone mineral density (BMD) pose several limitations in some patient categories, such as pregnant women and young people. This review article explores whether the innovative radiofrequency echographic multi-spectrometry (REMS) technology is beneficial for assessing the bone condition of various patient groups. Common consequences in patients with acromegalia, prostate cancer undergoing hormone therapy, osteogenesis imperfecta, anorexia nervosa, and in a peritoneal dialysis setting include decreased BMD and an increased risk of fragility fracture.DXA is currently regarded as the gold standard for BMD assessment. However, using the DXA technique has several drawbacks in a young patient who requires repeated BMD tests because it uses ionizing radiation. Because of its precision and consistency, the REMS technique may be a valuable tool to assess changes in bone condition in patients of all ages, particularly in female patients who are fertile or who are pregnant or nursing.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 5","pages":"547-556"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-10-15DOI: 10.1055/s-0044-1788693
Nico Sollmann, Michael Dieckmeyer, Julio Carballido-Gamio, Anh Tu Van, Dimitrios C Karampinos, Georg C Feuerriegel, Sarah C Foreman, Alexandra S Gersing, Roland Krug, Thomas Baum, Jan S Kirschke
Metabolic bone diseases (MBDs) are a diverse group of diseases, affecting the mass or structure of bones and leading to reduced bone quality. Parameters representing different aspects of bone health can be obtained from various magnetic resonance imaging (MRI) methods such as proton MR spectroscopy, as well as chemical shift encoding-based water-fat imaging, that have been frequently applied to study bone marrow in particular. Furthermore, T2* mapping and high-resolution trabecular bone imaging have been implemented to study bone microstructure. In addition, quantitative susceptibility mapping and ultrashort echo time imaging are used for trabecular and cortical bone assessment. This review offers an overview of technical aspects, as well as major clinical applications and derived main findings, for MRI-based assessment of bone quality in MBDs. It focuses on osteoporosis as the most common MBD.
{"title":"Magnetic Resonance Assessment of Bone Quality in Metabolic Bone Diseases.","authors":"Nico Sollmann, Michael Dieckmeyer, Julio Carballido-Gamio, Anh Tu Van, Dimitrios C Karampinos, Georg C Feuerriegel, Sarah C Foreman, Alexandra S Gersing, Roland Krug, Thomas Baum, Jan S Kirschke","doi":"10.1055/s-0044-1788693","DOIUrl":"https://doi.org/10.1055/s-0044-1788693","url":null,"abstract":"<p><p>Metabolic bone diseases (MBDs) are a diverse group of diseases, affecting the mass or structure of bones and leading to reduced bone quality. Parameters representing different aspects of bone health can be obtained from various magnetic resonance imaging (MRI) methods such as proton MR spectroscopy, as well as chemical shift encoding-based water-fat imaging, that have been frequently applied to study bone marrow in particular. Furthermore, T2* mapping and high-resolution trabecular bone imaging have been implemented to study bone microstructure. In addition, quantitative susceptibility mapping and ultrashort echo time imaging are used for trabecular and cortical bone assessment. This review offers an overview of technical aspects, as well as major clinical applications and derived main findings, for MRI-based assessment of bone quality in MBDs. It focuses on osteoporosis as the most common MBD.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 5","pages":"576-593"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-07-29DOI: 10.1055/s-0044-1779716
J Herman Kan, Olivia A Barron, Bryce R Bell
Alignment, longitudinal growth, and function of the musculoskeletal unit of the pediatric hand is complex due to the combination of open growth plates, ossification variations, and their relationship with finger tendinous and ligamentous attachments. This review presents the basics of normal development, acquired and congenital variations, and traumatic conditions of the pediatric hand from the perspective of the pediatric musculoskeletal radiologist and hand surgeon. This multimodality imaging article focuses on non-oncologic and non-rheumatologic conditions of the pediatric hand, inclusive of fingers, thumb, and metacarpal bones.
{"title":"Congenital and Traumatic Conditions of the Pediatric Hand: Overview for the Radiologist.","authors":"J Herman Kan, Olivia A Barron, Bryce R Bell","doi":"10.1055/s-0044-1779716","DOIUrl":"https://doi.org/10.1055/s-0044-1779716","url":null,"abstract":"<p><p>Alignment, longitudinal growth, and function of the musculoskeletal unit of the pediatric hand is complex due to the combination of open growth plates, ossification variations, and their relationship with finger tendinous and ligamentous attachments. This review presents the basics of normal development, acquired and congenital variations, and traumatic conditions of the pediatric hand from the perspective of the pediatric musculoskeletal radiologist and hand surgeon. This multimodality imaging article focuses on non-oncologic and non-rheumatologic conditions of the pediatric hand, inclusive of fingers, thumb, and metacarpal bones.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 4","pages":"424-436"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-07-29DOI: 10.1055/s-0044-1786153
Jade A Anderson, Nicholas Laucis, John Symanski, Donna Blankenbaker
The pediatric hip undergoes significant changes from infancy through adolescence. Proper maturation is crucial for the development of a stable and functional hip joint. Imaging interpretation of the pediatric hip requires distinguishing normal variants and maturation patterns from pathology. We review femoral ossification centers, variants, and conditions that affect the proximal femur, such as Legg-Calvé-Perthes disease; the acetabulum, such as developmental hip dysplasia; the acetabular labrum, such as femoroacetabular impingement; and synovial pathology in children through adolescence. Understanding the spectrum of hip conditions and using advanced imaging techniques are essential for the accurate diagnosis and effective management of pediatric hip disorders.
{"title":"Imaging of Disease and Normal Variant Patterns in Pediatric Hips.","authors":"Jade A Anderson, Nicholas Laucis, John Symanski, Donna Blankenbaker","doi":"10.1055/s-0044-1786153","DOIUrl":"https://doi.org/10.1055/s-0044-1786153","url":null,"abstract":"<p><p>The pediatric hip undergoes significant changes from infancy through adolescence. Proper maturation is crucial for the development of a stable and functional hip joint. Imaging interpretation of the pediatric hip requires distinguishing normal variants and maturation patterns from pathology. We review femoral ossification centers, variants, and conditions that affect the proximal femur, such as Legg-Calvé-Perthes disease; the acetabulum, such as developmental hip dysplasia; the acetabular labrum, such as femoroacetabular impingement; and synovial pathology in children through adolescence. Understanding the spectrum of hip conditions and using advanced imaging techniques are essential for the accurate diagnosis and effective management of pediatric hip disorders.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 4","pages":"447-461"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-07-29DOI: 10.1055/s-0044-1779717
Mobeen Farooq, Jeffrey A Belair, Vishal Desai
The pediatric shoulder girdle is a complex anatomical structure uniting the upper extremity and trunk. The osseous structures, their articulations, and the surrounding soft tissue support structures (muscles, tendons, and ligaments) allow for a wide range of motion at the shoulder. Growth and maturation of the components at the shoulder girdle vary, particularly the osseous structures. This characteristic renders interpretation of imaging of the pediatric shoulder girdle more challenging because normal or variant anatomy can be confused for pathology. We review the physiologic growth and maturation of the shoulder girdle with special emphasis on the development of the bones and their articulations. The role of various imaging modalities and the common osseous and soft tissue variants in the pediatric shoulder are also discussed.
{"title":"Pediatric Shoulder Girdle.","authors":"Mobeen Farooq, Jeffrey A Belair, Vishal Desai","doi":"10.1055/s-0044-1779717","DOIUrl":"https://doi.org/10.1055/s-0044-1779717","url":null,"abstract":"<p><p>The pediatric shoulder girdle is a complex anatomical structure uniting the upper extremity and trunk. The osseous structures, their articulations, and the surrounding soft tissue support structures (muscles, tendons, and ligaments) allow for a wide range of motion at the shoulder. Growth and maturation of the components at the shoulder girdle vary, particularly the osseous structures. This characteristic renders interpretation of imaging of the pediatric shoulder girdle more challenging because normal or variant anatomy can be confused for pathology. We review the physiologic growth and maturation of the shoulder girdle with special emphasis on the development of the bones and their articulations. The role of various imaging modalities and the common osseous and soft tissue variants in the pediatric shoulder are also discussed.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 4","pages":"384-395"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-07-29DOI: 10.1055/s-0044-1779247
Philip G Colucci, Carolyn M Sofka
The pediatric ankle can present a broad range of normal variation and pathology unique to certain stages of development. Understanding the expected age ranges of ossification and fusion about the ankle is essential to provide accurate diagnoses regarding skeletal integrity. This conclusion has been well characterized radiographically and is supported by cadaveric research.The range of appearances on magnetic resonance imaging has also been well described. Knowledge about the structure of the periosteum and perichondrium aids in image interpretation as well as explaining typical injury patterns. The expected appearance of the physis and regional bone marrow signal is also of utmost importance.Ultrasonography is a valuable tool in pediatric musculoskeletal imaging but is limited when there is concern for intra-articular pathology. Computed tomography tends to be reserved for preoperative evaluation. We describe normal variation and maturation-dependent pathology of the pediatric ankle with an emphasis on imaging considerations.
{"title":"The Pediatric Ankle: Normal Variations and Maturation-Dependent Pathology.","authors":"Philip G Colucci, Carolyn M Sofka","doi":"10.1055/s-0044-1779247","DOIUrl":"https://doi.org/10.1055/s-0044-1779247","url":null,"abstract":"<p><p>The pediatric ankle can present a broad range of normal variation and pathology unique to certain stages of development. Understanding the expected age ranges of ossification and fusion about the ankle is essential to provide accurate diagnoses regarding skeletal integrity. This conclusion has been well characterized radiographically and is supported by cadaveric research.The range of appearances on magnetic resonance imaging has also been well described. Knowledge about the structure of the periosteum and perichondrium aids in image interpretation as well as explaining typical injury patterns. The expected appearance of the physis and regional bone marrow signal is also of utmost importance.Ultrasonography is a valuable tool in pediatric musculoskeletal imaging but is limited when there is concern for intra-articular pathology. Computed tomography tends to be reserved for preoperative evaluation. We describe normal variation and maturation-dependent pathology of the pediatric ankle with an emphasis on imaging considerations.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 4","pages":"477-489"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gaucher's disease (GD) is a lysosomal storage disorder characterized by the storage of glucosylceramide in macrophages ("Gaucher cells"), mainly in the reticuloendothelial system. GD type 1 (GD1) is the most common phenotype that usually manifests with hepatosplenomegaly, cytopenias, and bone involvement. Skeletal manifestations are the most debilitating characteristic and result in significant morbidities. We describe a case of GD1, first presented by a nontraumatic bone fracture. The case presentation highlights the importance of considering GD among the differential diagnosis of nontraumatic fractures, avascular necrosis, and infarcts of the bones. Early diagnosis and treatment improve the course of disease and avoid irreversible sequelae.
{"title":"Skeletal Manifestations of Gaucher's Disease: A Case Report and Literature Review.","authors":"Rahma Nour Eldin Saad Mohamed, Walid A Elnahal, Cleofina Furtado, Rania Zeitoun, Nagui Abdel-Wahab","doi":"10.1055/s-0044-1782205","DOIUrl":"10.1055/s-0044-1782205","url":null,"abstract":"<p><p>Gaucher's disease (GD) is a lysosomal storage disorder characterized by the storage of glucosylceramide in macrophages (\"Gaucher cells\"), mainly in the reticuloendothelial system. GD type 1 (GD1) is the most common phenotype that usually manifests with hepatosplenomegaly, cytopenias, and bone involvement. Skeletal manifestations are the most debilitating characteristic and result in significant morbidities. We describe a case of GD1, first presented by a nontraumatic bone fracture. The case presentation highlights the importance of considering GD among the differential diagnosis of nontraumatic fractures, avascular necrosis, and infarcts of the bones. Early diagnosis and treatment improve the course of disease and avoid irreversible sequelae.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 4","pages":"505-510"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-07-29DOI: 10.1055/s-0044-1786697
Jie C Nguyen, Adam C Zoga
{"title":"Pediatric Musculoskeletal Variants.","authors":"Jie C Nguyen, Adam C Zoga","doi":"10.1055/s-0044-1786697","DOIUrl":"https://doi.org/10.1055/s-0044-1786697","url":null,"abstract":"","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 4","pages":"359-360"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}