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Late termination of pregnancy for fetal anomalies: Experience at a tertiary-care hospital in South Africa 因胎儿异常而延迟终止妊娠:南非一家三级护理医院的经验
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-10-28 DOI: 10.7196/SAJOG.1402
Fauziasham Shahid, P. Soma-Pillay
Background. Early diagnosis and appropriate management of congenital anomalies can help prevent neonatal morbidity and mortality. Termination of pregnancy for severe congenital anomalies is permitted under South African law.  Objective . To determine factors causing delayed diagnosis of lethal congenital abnormalities requiring late termination of pregnancy at Steve Biko Academic Hospital in Pretoria, South Africa.  Methods. Medical records of pregnant women who presented with lethal fetal anomalies over a period of 7.5 years were analysed. Patients’ demographic profile, the interval from referral to feticide, gestational age at first scan and diagnosis, type of anomaly and feticide methods were considered. The cohort was divided in two groups based on timing of termination (i.e. earlier than 28 weeks and later than 28 weeks’ gestation) for statistical comparison.  Results. The majority of women ( n =45; 78.9%) were younger than 35 years and had no chronic medical conditions or risk factors ( n =40; 70%). Although 30 women (52.6%) had been booked for antenatal examination early in their pregnancy, only three (5.2%) had a first-trimester scan. Mean time to referral was not significantly different between the women whose pregnancies terminated earlier than 28 weeks and those with a termination after 28 weeks ( p =0.671).  Conclusion. A basic ultrasound scan in the second trimester is recommended for all pregnant women. Task shifting can be a viable option to provide this facility at primary and secondary health centres. A national registry should be established to document all late terminations for fetal anomalies.
背景先天性畸形的早期诊断和适当管理有助于预防新生儿发病率和死亡率。南非法律允许因严重先天性畸形终止妊娠。目标。在南非比勒陀利亚的Steve Biko学术医院,确定导致需要延迟终止妊娠的致命先天性异常诊断延迟的因素。方法。对7.5年内出现致命胎儿畸形的孕妇的医疗记录进行了分析。考虑了患者的人口统计学特征、转诊至杀胎的间隔时间、首次扫描和诊断时的胎龄、异常类型和杀胎方法。根据终止妊娠的时间(即妊娠期早于28周和晚于28周),将队列分为两组进行统计比较。结果。大多数女性(n=45;78.9%)年龄小于35岁,没有慢性疾病或危险因素(n=40;70%)。尽管有30名妇女(52.6%)在怀孕早期预约了产前检查,但只有3名妇女(5.2%)进行了孕早期扫描。妊娠提前28周终止的妇女和28周后终止妊娠的妇女的平均转诊时间没有显著差异(p=0.671)。结论。建议所有孕妇在孕中期进行基本的超声波扫描。在初级和中级卫生中心提供这种设施时,任务转移可能是一个可行的选择。应建立一个国家登记处,记录所有因胎儿异常而延迟终止妊娠的情况。
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引用次数: 0
Procalcitonin: Blood tests are useful but must be interpreted with caution – inflammatory markers are no exception 降钙素原:血液测试是有用的,但必须谨慎解读——炎症标志物也不例外
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1484
W. Edridge
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引用次数: 0
Audit of routine tests in the antenatal period in women delivering at National District Hospital, Bloemfontein, South Africa, in 2016 2016年南非布隆方丹国家地区医院分娩妇女产前常规检查审计
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1438
W. J. Steinberg, G. Joubert, A. Adu-Parko, M. Godloza, N. P. Lehasa, N. Manele, N. Moselakgomo, M. Motsoikha
Background. Infectious diseases are transmissible from mother to unborn child. Appropriate treatment during antenatal care is crucial.  Objective. To determine whether routine antenatal tests (syphilis, HIV, Rhesus factor) were performed in women delivering at National District Hospital (NDH), Bloemfontein, South Africa, and whether treatment was initiated for women testing positive for these infections.  Methods. This descriptive retrospective study consisted of 2 425 women who delivered between January and December 2016. Antenatal care history was obtained from the delivery register.  Results. Nearly all women were tested for syphilis (99.1%), HIV (99.9%) and Rhesus factor (99.9%). A third (33.3%) of the patients who tested positive for syphilis were untreated. Of the 27.0% of patients who tested HIV-positive, 99.7% were recorded to have been on treatment. Just over half (54.3%) of the patients who tested Rhesus-negative received prophylaxis.  Conclusion. A record of routine antenatal testing of women delivering at NDH was found. The reaction to positive results could improve.
背景传染病可由母亲传染给未出生的孩子。产前护理期间的适当治疗至关重要。目标。确定是否对在南非布隆方丹国家地区医院分娩的妇女进行了常规产前检查(梅毒、艾滋病毒、恒河猴因子),以及是否对这些感染检测呈阳性的妇女进行治疗。方法。这项描述性回顾性研究包括2425名在2016年1月至12月期间分娩的女性。产前护理史是从分娩登记处获得的。结果。几乎所有女性都接受了梅毒(99.1%)、艾滋病毒(99.9%)和恒河猴因子(99.9%)的检测。三分之一(33.3%)的梅毒检测呈阳性的患者没有得到治疗。在27.0%的艾滋病毒检测呈阳性的患者中,99.7%的患者接受了治疗。在恒河猴检测呈阴性的患者中,超过一半(54.3%)的患者接受了预防治疗。结论。发现了在NDH分娩的妇女的常规产前检查记录。对积极结果的反应可能会有所改善。
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引用次数: 0
Adverse pregnancy outcomes associated with maternal prenatal ingestion of traditional medicine 与母体产前摄入传统药物相关的不良妊娠结局
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1423
N. Ngene, A. Siveregi
Pregnancy is associated with complications ranging from minor ailments to major morbidity and mortality. To prevent such complications, some women, including some in South Africa, resort to the use of traditional medicines. These are meant to either supplement or replace conventional medicines that are offered by their healthcare facilities. Some of these medicines, however, have the potential to cause harm, can increase pregnancy-related complications and may adversely interact with other medicines prescribed during the pregnancy. We present a case of an 18-year-old primigravida who commenced prenatal ingestion of traditional medicine ( moruto wamfene , otherwise called baboon urine) at 28 weeks’ gestation, in an attempt to improve her pregnancy outcomes. However, she instead developed uterine hyperstimulation, fetal bradycardia and thick meconium-stained liquor during labour. This report is intended to raise awareness about prenatal ingestion of traditional medicine (particularly moruto wamfene ), highlights the safety concerns and suggests preventive measures.
妊娠与并发症有关,从小病到严重的发病率和死亡率。为了防止这种并发症,一些妇女,包括南非的一些妇女,求助于使用传统药物。这些旨在补充或取代其医疗机构提供的传统药物。然而,其中一些药物有可能造成伤害,会增加与妊娠相关的并发症,并可能与妊娠期间开具的其他药物产生不利影响。我们报告了一例18岁的初产妇,她在怀孕28周时开始在产前摄入传统药物(moruto-wamfene,也称为狒狒尿),试图改善她的妊娠结局。然而,她在分娩过程中出现了子宫过度刺激、胎儿心动过缓和浓胎粪染色液。本报告旨在提高人们对产前摄入传统药物(特别是莫鲁托-瓦姆芬)的认识,强调安全问题,并提出预防措施。
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引用次数: 4
Contents 内容
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1486
Gertrude Fani
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引用次数: 0
A case of immune thrombocytopenic purpura complicated by HELLP syndrome 免疫性血小板减少性紫癜并发HELLP综合征1例
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1353
S. Prithipal
The combination of immune thrombocytopenic purpura and haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome is rare, with only two previous case reports published. Management of the two conditions is vastly different, and the diagnosis of HELLP syndrome superimposed on immune thrombocytopenic purpura may be difficult, resulting in delayed management.
免疫性血小板减少性紫癜和溶血、肝酶升高和低血小板(HELLP)综合征的结合是罕见的,以前只有两份病例报告发表。这两种情况的治疗有很大不同,HELLP综合征叠加免疫性血小板减少性紫癜的诊断可能很困难,导致治疗延迟。
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引用次数: 0
Successful pregnancy in a patient with Swyer syndrome, or pure 46,XY gonadal dysgenesis Swyer综合征或纯46,xy性腺发育不良患者的成功妊娠
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1448
A. Chrysostomou, M. Tsuari
Swyer syndrome, or pure 46,XY gonadal dysgenesis, is a rare disorder of sex development, characterised by the failure of sex gland development (ovaries or testes) in a phenotypic female patient. A 24-year-old woman with this syndrome presented at a tertiary academic hospital in South Africa, complaining of primary amenorrhoea and infertility. After gonadectomy and fertility treatment, a rare successful pregnancy outcome was achieved. A patient with Swyer syndrome, in a specialist fertility programme, can maintain a normal pregnancy and delivery.
Swyer综合征,或纯46,XY性腺发育不全,是一种罕见的性发育障碍,其特征是表型女性患者的性腺发育(卵巢或睾丸)失败。一名患有该综合征的24岁女性在南非一家三级学术医院就诊,抱怨原发性闭经和不孕。经过性腺切除和生育治疗,获得了罕见的成功妊娠结局。在专业生育计划中,Swyer综合征患者可以维持正常的妊娠和分娩。
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引用次数: 2
Evaluation of the effect of 10% lidocaine spray on reducing the pain of intrauterine device insertion: A randomised controlled trial 10%利多卡因喷雾剂减轻宫内节育器插入疼痛的效果评价:一项随机对照试验
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1383
M. Hajiesmaello, E. Mohammadi, H. Farrokh-Eslamlou
Background. The intrauterine device (IUD) is among the most efficient contraceptive methods. However, IUD insertion is accompanied by pain and discomfort.  Objectives. To evaluate the analgesic effects of 10% lidocaine spray in reducing pain during IUD insertion.  Method. In a randomised clinical trial, 80 volunteers attending two clinics for IUD insertion were selected for study, and randomly allocated to two groups. The intervention group received four puffs of 10% lidocaine spray on their cervix prior to IUD insertion. The routine procedure (without an analgesic) was followed in the control group. The intensity of perceived pain in both groups was measured using a visual analogue scale from 0 to 10.  Results. The two groups had significant differences in pain intensity at all stages of the procedure ( p <0.001). The most painful stage of the procedure was tenaculum placement (mean (standard deviation) pain intensity 2.2 (1.34) in the intervention group; 4.25 (1.92) in the control group).  Conclusion. Based on our findings, 10% lidocaine spray can be applied as a non-invasive, inexpensive, easy-to-use and accessible method to decrease IUD insertion pain.
背景宫内节育器是最有效的避孕方法之一。然而,宫内节育器的插入伴随着疼痛和不适。目标。评价10%利多卡因喷雾剂减轻宫内节育器置入过程中疼痛的镇痛效果。方法。在一项随机临床试验中,80名志愿者被选入两个诊所进行宫内节育器插入研究,并被随机分配到两组。在插入宫内节育器之前,干预组在其宫颈上接受了四次10%利多卡因喷雾。对照组采用常规程序(无镇痛药)。使用0至10的视觉模拟量表测量两组患者的感知疼痛强度。两组在手术的各个阶段的疼痛强度都有显著差异(p<0.001)。手术最疼痛的阶段是肌腱放置(干预组的平均(标准差)疼痛强度为2.2(1.34);对照组为4.25(1.92)。结论。根据我们的研究结果,10%利多卡因喷雾剂可以作为一种非侵入性、廉价、易于使用和可获得的方法来减少宫内节育器插入疼痛。
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引用次数: 0
Serum procalcitonin in pregnancy-associated sepsis: A case control study 妊娠相关性败血症患者血清降钙素原的病例对照研究
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1397
R. Agarwal, P. Priyadarshini, M. Mehndiratta
Background. Procalcitonin (PCT) is an established marker for sepsis, particularly bacterial, but its use in diagnosing pregnancy-associated sepsis (PAS) is relatively unexplored.  Objective. To investigate whether PCT could be used for the diagnosis of PAS in our study population, and what the appropriate values might be for the diagnosis.  Methods. The study included 40 pregnant, post-abortal and postpartum women with PAS, identified using systemic inflammatory response syndrome criteria. Patients with hypertensive disorders, premature rupture of membranes, severe trauma, liver cirrhosis and lung or thyroid malignancies were excluded. Forty healthy term pregnant women with sterile urine cultures were taken as controls. PCT levels were obtained at admission and statistically compared between the groups. Severity and culture positivity in PAS were also assessed.  Results. Severe PAS was present in 30 patients. Overall culture positivity was seen in 55% ( n =22) of subjects. Culture-positive patients had higher PCT levels (3.03 μg/L) compared with the culture-negative (1.77 μ/L), though this did not reach statistical significance ( p =0.235). Mean (standard deviation) PCT in PAS patients was 2.46 (0.56) μ/L, while in healthy controls it was 0.091 (0.019) μg/L. This difference was statistically significant ( p 0.125 μg/L is suggested as the critical level for PAS diagnosis in appropriate clinical settings. Additionally, mean PCT levels differed significantly in severe v. non-severe PAS.
背景降钙素原(PCT)是一种已确定的败血症,特别是细菌性败血症的标志物,但其在诊断妊娠相关败血症(PAS)中的应用相对未被探索。目标。研究PCT是否可用于我们研究人群中PAS的诊断,以及诊断的合适值。方法。该研究纳入了40名患有PAS的孕妇、流产后和产后妇女,采用全身炎症反应综合征标准进行鉴定。排除患有高血压疾病、胎膜早破、严重创伤、肝硬化和肺部或甲状腺恶性肿瘤的患者。40名健康足月孕妇接受无菌尿液培养作为对照。PCT水平在入院时获得,并在两组之间进行统计学比较。PAS的严重程度和培养阳性率也进行了评估。结果。30例患者出现严重PAS。55%(n=22)的受试者总体文化阳性。培养物阳性患者的PCT水平(3.03μg/L)高于培养物阴性患者(1.77μg/L),但没有达到统计学意义(p=0.235)。PAS患者的平均(标准差)PCT为2.46(0.56)μ/L,而健康对照组为0.091(0.019)μg/L。这种差异具有统计学意义(在适当的临床环境中,0.125μg/L被认为是PAS诊断的临界水平。此外,严重PAS与非严重PAS的平均PCT水平差异显著。
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引用次数: 5
An audit of the CaesAid vacuum-assisted delivery cup compared with forceps delivery of the fetal head in caesarean section 剖宫产中使用CaesAid真空助产杯与产钳娩出胎儿头的比较分析
Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2019-08-27 DOI: 10.7196/sajog.1377
N. Stolwijk, P. R. Jong
Background. Vacuum-assisted caesarean delivery may result in a quicker delivery of the fetal head than the use of forceps, and improve maternal and fetal outcomes. The new CaesAid vacuum-assisted delivery (VAD) cup was designed specifically for this use.  Objectives. To assess whether the CaesAid VAD cup influences the duration of fetal head delivery at caesarean section when compared with forceps, and whether there are differences in perioperative complications in the mother and fetus.  Methods. We carried out a retrospective clinical audit of 132 patients who underwent caesarean delivery at the Netcare Christiaan Barnard Memorial Hospital in Cape Town, South Africa, from April to November 2017, aided by either CaesAid VAD cup (C group, n =67) or forceps (F group, n =65).  Results. The uterine incision-to-delivery interval was significantly shorter ( p =0.001) in the C group than the F group (median 38 (interquartile range (IQR) 20) v. 60 (IQR 50) seconds, respectively). The maternal blood loss was lower in the C group than the F group (250 mL v. 288 mL; p =0.025). There was no significant difference in Apgar scores or admissions to the neonatal intensive care unit. Neonatal skin injuries were less common in the C group (no cases v. 8 in the F group; p =0.004).  Conclusion. The results of this audit suggest that the CaesAid VAD cup is a safe and efficient alternative to forceps for aiding the delivery of the fetal head at caesarean section. However, the routine use of vacuum cups is debatable. Further research could provide more insight into this procedure as a part of obstetric practice.
背景。与使用产钳相比,真空辅助剖宫产可以更快地娩出胎儿头,并改善产妇和胎儿的结局。新的凯撒真空辅助分娩(VAD)杯是专门为这种使用而设计的。目标。评估与产钳相比,CaesAid VAD杯是否影响剖宫产时胎头娩出时间,以及母婴围手术期并发症是否存在差异。方法。我们对2017年4月至11月在南非开普敦Netcare克里斯蒂安巴纳德纪念医院(Netcare Christiaan Barnard Memorial Hospital)剖腹产的132例患者进行了回顾性临床审计,这些患者使用CaesAid VAD杯(C组,n =67)或产钳(F组,n =65)辅助。结果。C组子宫切开至分娩间隔明显短于F组(中位数38(四分位间距(IQR) 20)和60 (IQR 50)秒)(p =0.001)。C组产妇失血量低于F组(250 mL vs 288 mL;p = 0.025)。在阿普加评分或新生儿重症监护病房入院方面没有显著差异。C组新生儿皮肤损伤发生率较低(0例vs . F组8例;p = 0.004)。结论。本审计结果表明,CaesAid VAD杯是一种安全、有效的替代产钳辅助剖宫产胎儿头娩出的方法。然而,常规使用真空杯是有争议的。进一步的研究可以提供更多的深入了解这一程序作为产科实践的一部分。
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引用次数: 0
期刊
South African Journal of Obstetrics and Gynaecology
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