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Developing Spanish Language Intervention Content to Address Health Disparities among People Who Use Drugs, and Other Hard-To-Reach Populations. 开发西班牙语干预内容,以解决吸毒者和其他难以接触人群之间的健康差异。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-07 DOI: 10.1007/s11524-025-01050-2
Ian David Aronson, Anthony Cramer, Robert Quiles, Olivia Marcus, Brent Gibson, Brittney Vargas-Estrella, Synn Stern, Chunki Fong, Alex S Bennett

Our team developed content in English and Spanish for a technology-based intervention designed to increase vaccination against COVID-19 among people who inject drugs. From 2022 through 2024, we recruited 545 participants via peer referral, all of whom reported past 90-day injection drug use. Participants completed a tablet-based intervention, and software asked if they would like to vaccinate against COVID. Participants who did not vaccinate at the first visit received follow-up text messages. Participants who completed the intervention in Spanish were more than 2.5 times as likely to vaccinate at first visit (OR 2.525, 95% CI [1.059-6.076], p = 0.039), and 57% more likely to vaccinate at follow-up (OR 1.576, 95% CI [0.441-5.630], p = 0.484) compared to those who completed in English. These findings highlight the importance of developing intervention materials in languages beyond English. Research is warranted to understand how developing content in other languages may influence health outcomes.

我们的团队为一项基于技术的干预措施开发了英语和西班牙语内容,旨在增加注射吸毒者的COVID-19疫苗接种。从2022年到2024年,我们通过同伴推荐招募了545名参与者,他们都报告了过去90天的注射吸毒情况。参与者完成了一项基于平板电脑的干预,软件询问他们是否愿意接种COVID疫苗。在第一次访问时没有接种疫苗的参与者收到了后续短信。用西班牙语完成干预的参与者在首次就诊时接种疫苗的可能性是用英语完成干预的参与者的2.5倍以上(OR 2.525, 95% CI [1.059-6.076], p = 0.039),在随访时接种疫苗的可能性比用英语完成干预的参与者高57% (OR 1.576, 95% CI [0.441-5.630], p = 0.484)。这些发现强调了开发英语以外语言的干预材料的重要性。有必要进行研究,以了解开发其他语言的内容如何影响健康结果。
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引用次数: 0
Within-City Average Life Expectancy "Gaps": A Useful Health Equity Metric. 城市平均预期寿命“差距”:一个有用的健康公平指标。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-26 DOI: 10.1007/s11524-025-01023-5
Ben R Spoer, Isabel S Nelson, Matthew Lee, Anne Vierse, Alexander S Chen, Andrea R Titus, Lorna E Thorpe, Marc N Gourevitch

We characterize within-city life expectancy gaps and their correlation with social and environmental characteristics in 948 US cities. Life expectancy estimates were drawn from the US Life Expectancy Estimation Program. City life expectancy gaps were calculated by subtracting the lowest tract-level life expectancy estimate from the highest for each city. Correlations were established using Spearman's correlation coefficient. The average city-level life expectancy gap in our sample was 11.8 years. Life expectancy gaps were larger in cities with lower average life expectancy and were evident across the USA. Life expectancy gaps of a decade were seen even in smaller cities and in high life expectancy cities. Life expectancy gaps were most strongly correlated with racialized residential segregation, children in poverty, and household income. Significant between-neighborhood gaps in life expectancy exist across US cities. Life expectancy gaps present a compelling target for establishing robust health equity goals.

我们描述了948个美国城市的城市内预期寿命差距及其与社会和环境特征的相关性。预期寿命估算来自美国预期寿命估算项目。城市预期寿命差距是通过从每个城市的最高预期寿命估计值中减去最低预期寿命估计值来计算的。利用Spearman相关系数建立相关关系。在我们的样本中,城市平均预期寿命差距为11.8岁。在平均预期寿命较低的城市,预期寿命差距更大,在美国各地都很明显。即使在较小的城市和预期寿命较高的城市,预期寿命也存在10年的差距。预期寿命差距与种族化的居住隔离、贫困儿童和家庭收入密切相关。美国各城市的预期寿命存在显著的邻里差距。预期寿命差距是确立强有力的卫生公平目标的一个引人注目的具体目标。
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引用次数: 0
Physical Health Challenges, Healthcare Needs, and Barriers to Care among Firearm Injury Survivors: A Mixed Methods Analysis. 火器伤害幸存者的身体健康挑战、医疗保健需求和护理障碍:混合方法分析。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-26 DOI: 10.1007/s11524-025-01049-9
Daniel C Semenza, Nazsa S Baker, Devon Ziminski, Jeanna M Mastrocinque, Darnell Whye, Lesly Heredia

Firearm injury survivors often face significant physical, mental, and logistical challenges following their injury, yet research on their healthcare needs remains limited. This mixed methods study examines health challenges, healthcare needs, and barriers to care among 107 firearm injury survivors in a small Northeastern city. The project emerged from a collaboration between university researchers and community-based violence prevention specialists. Participants completed a cross-sectional survey assessing physical health, functional disability, healthcare access, and demographic factors. A subsample of 15 survivors also participated in semi-structured interviews. Quantitative results show that a majority of survivors experience pain, require regular medical treatment, and report functional impairments that interfere with daily life. Respondents report high levels of unmet healthcare needs, including access to affordable care, specialists, and primary providers. Barriers to care include cost, lack of insurance, unreliable transportation, and difficulty navigating the healthcare system. Qualitative interviews illustrated the toll of post-injury pain, trauma, and anxiety, while also highlighting resilience, self-directed care, and changes in care-seeking behavior. Survivors voiced concerns about medication access, potential addiction, and logistical burdens. The findings underscore the complexity of survivor needs and point to opportunities for hospital-based violence intervention programs and trauma recovery centers to play a larger role in post-injury care coordination. This study highlights the value of participatory, community-engaged research in illuminating the lived experiences of firearm injury survivors and advancing care models that address both structural and personal barriers to recovery.

枪支伤害幸存者在受伤后往往面临重大的身体、精神和后勤挑战,但对他们的医疗保健需求的研究仍然有限。这项混合方法研究调查了东北部一个小城市107名枪伤幸存者的健康挑战、医疗保健需求和护理障碍。该项目源于大学研究人员和社区暴力预防专家之间的合作。参与者完成了一项横断面调查,评估身体健康、功能残疾、医疗保健获取和人口因素。15名幸存者的子样本也参加了半结构化访谈。定量结果显示,大多数幸存者经历疼痛,需要定期治疗,并报告干扰日常生活的功能障碍。答复者报告了大量未得到满足的医疗保健需求,包括获得负担得起的医疗服务、专科医生和初级提供者。治疗的障碍包括费用、缺乏保险、不可靠的交通以及难以驾驭医疗保健系统。定性访谈说明了受伤后疼痛、创伤和焦虑的代价,同时也强调了复原力、自我指导的护理和寻求护理行为的变化。幸存者表达了对药物获取、潜在成瘾和后勤负担的担忧。研究结果强调了幸存者需求的复杂性,并指出了以医院为基础的暴力干预项目和创伤恢复中心在创伤后护理协调中发挥更大作用的机会。这项研究强调了参与性、社区参与的研究在阐明枪支伤害幸存者的生活经历和推进解决结构和个人康复障碍的护理模式方面的价值。
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引用次数: 0
Pathways Connecting Housing Assistance to Child Well-Being in Families Experiencing Homelessness. 连接住房援助与无家可归家庭儿童福祉的途径。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-20 DOI: 10.1007/s11524-025-01029-z
Renae Wilkinson, Aashna Lal, Michel H Boudreaux, Andrew Fenelon, Marybeth Shinn, Natalie Slopen

Recent increases in family homelessness place children at heightened risk for long-term health challenges. Research has shown that long-term rental subsidies reduce emotional-behavioral and sleep problems among children in homeless families, but the pathways driving these effects are not well understood. This study examined mediating pathways between assignment to housing assistance interventions and improvements in children's emotional-behavioral and sleep outcomes three years later. We used data from the Family Options Study (FOS), a randomized controlled trial by the US Department of Housing and Urban Development, which enrolled approximately 2,300 families that experienced an emergency shelter stay across 12 US sites. Findings from mediation models adjusting for baseline family and child characteristics to test five candidate mediators-homelessness, intimate partner violence, food insecurity, economic stress, psychological distress-as potential pathways linking housing interventions with children's emotional-behavioral and sleep problems indicated that approximately half (50.7%) of the impact of priority access to long-term rental subsidies (versus usual care) on decreased child emotional-behavior problems operated indirectly through lowered parent stressors, specifically economic and psychological distress. Conversely, the impact of priority access to long-term rental subsidies on decreased child sleep problems was predominantly direct, with minimal evidence of mediation. These findings suggest that stabilizing housing is foundational for children, and its benefits extend to family well-being. Additional research is needed to identify other modifiable pathways to improved child health.

最近家庭无家可归现象的增加使儿童面临更大的长期健康挑战风险。研究表明,长期租房补贴减少了无家可归家庭儿童的情绪行为和睡眠问题,但推动这些影响的途径尚未得到很好的理解。本研究考察了分配住房援助干预与三年后儿童情绪行为和睡眠结果改善之间的中介途径。我们使用了家庭选择研究(FOS)的数据,这是一项由美国住房和城市发展部进行的随机对照试验,该试验招募了大约2300个家庭,这些家庭在美国12个地点经历了紧急避难所。根据基线家庭和儿童特征调整调解模型的结果,以测试五个候选调解人——无家可归、亲密伴侣暴力、粮食不安全、经济压力、心理困扰——作为将住房干预与儿童情绪行为和睡眠问题联系起来的潜在途径——表明,优先获得长期租赁补贴(与常规护理相比)对减少儿童情绪行为问题的影响约有一半(50.7%)间接通过降低父母压力源(特别是经济和心理压力)起作用。相反,优先获得长期租赁补贴对减少儿童睡眠问题的影响主要是直接的,调解的证据很少。这些发现表明,稳定的住房是儿童的基础,它的好处延伸到家庭幸福。需要进一步的研究来确定改善儿童健康的其他可改变的途径。
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引用次数: 0
Identifying Synergistic Mechanisms of Community-Led Policy, Systems, and Environmental Change for Childhood Obesity Prevention in the Multi-Site Catalyzing Communities Initiative. 在多地点催化社区倡议中,识别社区主导的政策、系统和环境变化对儿童肥胖预防的协同机制。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-07 DOI: 10.1007/s11524-025-01046-y
Travis R Moore, Yuilyn A Chang Chusan, Rebecca Neergaard, Erin Hennessy, Larissa Calancie, Christina D Economos, Shiriki Kumanyika

This evaluation reports how the Catalyzing Communities Initiative, a whole-of-community, multi-site intervention, supported equity-focused policy, systems, and environmental (PSE) changes to prevent childhood obesity in three U.S. communities from 2023 to 2024. We conducted a mixed-methods evaluation using survey data from 35 committee members (multisector representatives selected by local health-promotion leaders) and interviews with 29 committee members across three communities. We used a three-framework analytic approach: the Getting to Equity Framework was used to classify PSE changes, the Consolidated Framework for Implementation Research guided analysis of contextual influences, and Ripple Effects Mapping, a systems science method, identified how PSE-related actions created chains of perceived impacts over time. Committee members reported a total of 339 PSE impacts, defined as perceived changes attributed to specific PSE-related actions, such as shifts in partnerships, practices, or community conditions. The majority of impacts fell within Getting to Equity Quadrants 4 (increasing community capacity and opportunity) and 1 (increasing healthy options). Systems thinking tools that were used by committee members as part of the Catalyzing Communities Initiative were noted to enhance cross-sector coordination. Ripple effect maps revealed reinforcing loops, such as systems-informed community action and community mobilization, that enhanced cross-sector collaboration and contributed to synergistic change. Implementation facilitators of change included strong leadership and supportive policy environments, while key barriers included affordability, stigma, and exposure to community violence. Findings illustrate how integrating equity frameworks, implementation science, and Ripple Effects Mapping can reveal mechanisms through which local actions promote equity-oriented change.

本评估报告了催化社区倡议,一个全社区,多站点干预,如何支持以公平为重点的政策,系统和环境(PSE)变化,以防止2023年至2024年美国三个社区的儿童肥胖。我们使用来自35名委员会成员(由当地健康促进领导人选择的多部门代表)的调查数据和来自三个社区的29名委员会成员的访谈进行了混合方法评估。我们使用了三框架分析方法:实现公平框架用于对PSE变化进行分类,实施研究统一框架指导上下文影响分析,涟漪效应映射,一种系统科学方法,确定PSE相关行动如何随着时间的推移产生可感知的影响链。委员会成员共报告了339个PSE影响,定义为归因于特定PSE相关行动的感知变化,例如伙伴关系,实践或社区条件的变化。大多数影响属于实现公平象限4(增加社区能力和机会)和1(增加健康选择)。委员会成员作为催化社区倡议的一部分使用的系统思考工具被注意到可以加强跨部门协调。涟漪效应图揭示了加强循环,如系统知情的社区行动和社区动员,这些循环加强了跨部门协作并促进了协同变革。变革的实施促进因素包括强有力的领导和支持性政策环境,而主要障碍包括负担能力、污名化和暴露于社区暴力。研究结果表明,整合公平框架、实施科学和涟漪效应映射可以揭示地方行动促进公平导向变革的机制。
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引用次数: 0
Restaurant Advertising Expenditure Patterns in US Counties by Race, Ethnicity, and Income. 美国各县按种族、民族和收入划分的餐馆广告支出模式。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-06 DOI: 10.1007/s11524-025-01039-x
Briana Joy K Stephenson, Sara N Bleich, Dania V Francis, Keren M Horn

Recent growth in the share of household dollars spent on food consumed outside the home, in combination with growing obesity disparities, has heightened interest in food advertising by geography and population demographics. This study aimed to identify changes in advertising expenditure by US restaurant chains across counties, grouped by income, race, and ethnicity, specifically examining whether the lowest income and highest percentage of Black and Hispanic/Latino residents are disproportionately impacted by these trends. Using expenditure and location data for the top-100 grossing US restaurant chains and county-level demographic information, we measured patterns and trends in advertising expenditure at the county level. US counties were split by population density and socio-demographics. Quantile regression analysis was performed to identify baseline differences in total spending within county groups, as well as changes over time. Results show that fast food restaurant chains reported the highest expenditures among the types of restaurants and that the majority of advertising dollars were spent on television advertisements within the highest density counties. Our results show that-for all density types-the lowest levels and the greatest declines of advertising dollars occur among high-income counties and those with a low proportion of Black and Hispanic/Latino residents. Within the lowest density (rural) counties, the highest expenditure rates occurred in counties with a high proportion of Black and Hispanic/Latino residents, regardless of income. Among the highest density (urban) counties, the highest spending levels were observed in low-income counties. Together, these results suggest that restaurant advertising dollars in high- and low-density counties are consistently targeted toward populations who are also at greater risk for obesity in the United States.

最近,家庭支出在家庭外消费食品上的份额有所增长,再加上肥胖差距的扩大,提高了人们对地理和人口统计学上的食品广告的兴趣。本研究旨在确定美国连锁餐厅广告支出的变化,按收入、种族和民族分组,特别检查收入最低和比例最高的黑人和西班牙裔/拉丁裔居民是否不成比例地受到这些趋势的影响。利用美国收入最高的100家连锁餐厅的支出和位置数据以及县级人口统计信息,我们衡量了县级广告支出的模式和趋势。美国各县按人口密度和社会人口统计学划分。进行分位数回归分析,以确定县组内总支出的基线差异,以及随时间的变化。结果显示,快餐连锁餐厅在各类餐厅中支出最高,而在人口密度最高的县,大部分广告资金都花在了电视广告上。我们的研究结果表明,在所有的人口密度类型中,广告支出的最低水平和最大降幅出现在高收入县以及黑人和西班牙裔/拉丁裔居民比例较低的县。在人口密度最低的县(农村),无论收入如何,最高的支出率发生在黑人和西班牙裔/拉丁裔居民比例高的县。在人口密度最高的(城市)县中,低收入县的支出水平最高。综上所述,这些结果表明,在人口密度高和人口密度低的县,餐馆的广告费用始终针对的是美国肥胖风险更高的人群。
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引用次数: 0
Effect of Gentrification and Residential Mobility on Associations Between Historical Redlining and Life Expectancy at Birth. 高档化和居住流动对历史红线与出生时预期寿命关系的影响。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-03 DOI: 10.1007/s11524-025-01041-3
Daniel Wiese, Jordan Baeker Bispo, Ann C Klassen, Charnita Zeigler-Johnson, Ahmedin Jemal, Kevin A Henry, Farhad Islami

Historical redlining, a housing policy applied across numerous cities in the United States in the 1930s, resulted in disinvestment in predominantly non-White, immigrant, or impoverished neighborhoods and has been associated with various adverse health outcomes. However, little is known about the effects of gentrification and residential mobility on health in historically redlined neighborhoods. Using linear regression, we evaluated the association between redlining, gentrification, and life expectancy at birth before and after adjustment for socio-spatial residential mobility in the Philadelphia metropolitan area. Tract-level data on life expectancy were obtained from the Centers for Disease Control and Prevention. Census data were used to define tract gentrification status in 2000-2010 (earlier-gentrification) and 2011-2018 (recent-gentrification). Tract socio-spatial mobility characteristics were defined using DataAxle's household-level data. Life expectancy at birth was generally higher in historically privileged than disadvantaged tracts. After stratification by gentrification status, however, life expectancy in historically disadvantaged (redlined) areas was higher in earlier-gentrified than non-gentrified tracts. This difference was largely explained by socio-spatial mobility, namely a greater influx of moderate- and higher-income households to gentrified and lower-income households to non-gentrified tracts. In redlined tracts, for example, life expectancy in the unadjusted model was 4.7 years lower in non-gentrified than earlier-gentrified tracts (confidence interval: - 6.4, - 2.9); this difference decreased to 1.7 years (- 3.2, - 0.1) after adjustment for socio-spatial mobility. These findings have substantial implications for future public health research, highlighting the importance of including gentrification and/or socio-spatial mobility data when evaluating the association between historical policies, like redlining, and health outcomes in a given geographic area.

20世纪30年代,美国许多城市实施了一项历史性的住房政策,导致以非白人、移民或贫困社区为主的投资减少,并与各种不良健康后果有关。然而,人们对高档化和住宅流动性对历史上红线社区的健康影响知之甚少。使用线性回归,我们评估了在调整社会空间居住流动性之前和之后,费城大都市地区的红线、中产阶级化和出生时预期寿命之间的关系。平均寿命的数据来自美国疾病控制与预防中心。人口普查数据用于定义2000-2010年(较早的高档化)和2011-2018年(最近的高档化)的土地高档化状况。使用DataAxle的家庭级数据定义了区域社会空间流动性特征。在历史上享有特权的地区,出生时的预期寿命通常高于处于不利地位的地区。然而,在按高档化地位分层之后,在历史上处于不利地位的地区(红线),较早高档化的地区的预期寿命高于非高档化地区。这种差异在很大程度上可以用社会空间流动性来解释,即更多中高收入家庭涌入高档化地区,而低收入家庭涌入非高档化地区。例如,在红线地区,未经调整的模型显示,非中产阶级化地区的预期寿命比早期中产阶级化地区低4.7年(置信区间:- 6.4,- 2.9);在调整社会空间流动性后,这一差异减少到1.7年(- 3.2年,- 0.1年)。这些发现对未来的公共卫生研究具有重大意义,强调了在评估历史政策(如划红线)与特定地理区域的健康结果之间的关系时,包括高档化和/或社会空间流动性数据的重要性。
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引用次数: 0
"This is Going to Get Worse": Immigrant Reactions to the Public Charge Rule in a Large Northeastern City. “情况会变得更糟”:东北某大城市移民对公共负担规定的反应。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-12-29 DOI: 10.1007/s11524-025-01044-0
Makini Chisolm-Straker, Claudia Calhoon, Elika A Nerette, Cindy Clesca, Laura Janneck, Kristin Potterbusch, Michelle P Lin

The United States' public charge rule restricting who may enter or receive residency was expanded by the 2016 - 2020 federal administration and may be expanded again. This phenomenological study examines immigrant understandings of the use of public benefits and the consequences of penalizing immigrants in this way. As a feasibility study, it serves as an example of the merits and challenges of community-based organization (CBO) qualitative research. From September 2019 - April 2021, workers in a large urban CBO interviewed six immigrant participants about the public charge rule. We identify four themes: 1) mixed understandings, 2) avoidance of public benefits due to fear, 3) impact on children, and 4) interconnectedness. We describe immigrant insights on how anti-immigrant policies harm a nation as a whole.

2016年至2020年,美国联邦政府扩大了限制谁可以进入或获得居留权的公共负担规定,并可能再次扩大。这一现象学研究考察了移民对公共福利使用的理解,以及以这种方式惩罚移民的后果。作为一项可行性研究,它可以作为社区组织定性研究的优点和挑战的一个例子。从2019年9月到2021年4月,一个大城市CBO的工作人员就公共负担规则采访了六名移民参与者。我们确定了四个主题:1)混合理解,2)由于恐惧而避免公共利益,3)对儿童的影响,以及4)相互联系。我们描述了反移民政策如何损害整个国家的移民见解。
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引用次数: 0
Active Travel Commuting and Autonomic Stress Recovery in Urban Populations. 城市人口主动出行通勤与自主应激恢复
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-12-23 DOI: 10.1007/s11524-025-01047-x
Liang Ma

Urban commuters increasingly face chronic stress, a known risk factor for cardiovascular and mental health issues. Active travel modes-such as walking or cycling-can potentially mitigate stress by integrating physical activity into daily routines; however, their effect on autonomic stress regulation remains unclear. This study aims to examine how different commuting modes influence autonomic nervous system recovery from stress in real-world urban environments. We analyzed minute-by-minute heart rate variability (HRV) data collected by wearable devices from 200 urban commuters in Beijing over 1 week, capturing HRV before, during, and after daily commutes. Active commuters demonstrated a 7.6% faster return to baseline HRV compared with passive commuters, indicating a more rapid recovery from commuting-induced stress. Notably, while overall active commuting supported faster recovery, higher levels of moderate-to-vigorous physical activity during the commute were associated with slower short-term recovery, suggesting that the intensity of exertion matters. These findings highlight that active commuting enhances both physical fitness and stress resilience, while emphasizing the importance of comfortable, moderate-intensity active travel conditions. The results support targeted investments in pedestrian and cycling infrastructure-particularly routes that are safe, connected, and designed to avoid excessive physical strain-to foster healthier, less stressed urban populations.

城市通勤者越来越多地面临慢性压力,这是心血管和心理健康问题的已知风险因素。积极的旅行模式,如步行或骑自行车,可以通过将体育活动融入日常生活中来潜在地减轻压力;然而,它们对自主应激调节的影响尚不清楚。本研究旨在探讨在现实城市环境中,不同的通勤方式如何影响自主神经系统从压力中恢复。我们分析了通过可穿戴设备收集的北京200名城市通勤者一周内每分钟的心率变异性(HRV)数据,记录了每天通勤之前、期间和之后的HRV。与被动通勤者相比,主动通勤者恢复基线HRV的速度快7.6%,这表明从通勤引起的压力中恢复得更快。值得注意的是,虽然总体上积极的通勤支持更快的恢复,但通勤期间较高水平的中等到剧烈的身体活动与较慢的短期恢复有关,这表明运动强度很重要。这些发现强调了主动通勤可以增强身体健康和压力恢复能力,同时强调了舒适、中等强度的主动出行条件的重要性。研究结果支持对行人和自行车基础设施进行有针对性的投资,特别是安全、连通、设计避免过度体力紧张的路线,以培养更健康、压力更小的城市人口。
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引用次数: 0
Racialized economic segregation in relation to fecundability in a preconception cohort study. 一项孕前队列研究中种族化的经济隔离与生育能力的关系。
IF 4.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-12-20 DOI: 10.1007/s11524-025-01038-y
Sharonda M Lovett, Erin J Campbell, Andrea S Richardson, Amelia K Wesselink, Collette N Ncube, Yvette C Cozier, Lauren A Wise, Mary D Willis

Racialized economic segregation is a known determinant of health disparities that has been associated with adverse pregnancy outcomes. However, no study has investigated its association with fecundability, the per-cycle probability of conception. We analyzed data from 10,438 U.S. participants enrolled in Pregnancy Study Online (2013-2022), an internet-based preconception cohort study. Eligible participants were aged 21-45 years, assigned female at birth, and trying to conceive without fertility treatment use. Using baseline residential addresses, we calculated segregation based on the Index of Concentration at the Extremes (ICE) from the American Community Survey 5-year estimates. ICE ranges from -1 ("disadvantaged") to 1 ("privileged"). We operationalized ICE metrics at the census tract level: economic segregation (ICEincome: ≥ $100 k vs. < $25 k), racial segregation (ICEwhite/black: non-Hispanic White vs. non-Hispanic Black), and racialized economic segregation (ICEincome + white/black: non-Hispanic White ≥ $100 k vs. non-Hispanic Black < $25 k). We used proportional probabilities regression models to estimate fecundability ratios (FRs) and 95% confidence intervals (CIs), adjusting for precision variables. We observed a monotonic inverse association for increasing quintiles of ICEincome and ICEincome + white/black with fecundability, but less evidence of associations with ICEwhite/black. For instance, relative to ICEincome + white/black quintile 5 ("most privileged"), FRs for quintiles 4, 3, 2, and 1 ("most disadvantaged") were 0.92 (95% CI = 0.86-0.99), 0.84 (95% CI = 0.78-0.90), 0.84 (95% CI = 0.78-0.90), and 0.79 (95% CI = 0.73-0.86), respectively. Living in the most disadvantaged neighborhoods with respect to racialized economic segregation was associated with a moderate decrease in fecundability.

种族化的经济隔离是与不良妊娠结局相关的健康差异的一个已知决定因素。然而,没有研究调查其与生育能力,每周期受孕概率的关系。我们分析了10438名参加在线妊娠研究(2013-2022)的美国参与者的数据,这是一项基于互联网的孕前队列研究。符合条件的参与者年龄在21-45岁之间,出生时被指定为女性,并且试图在不使用生育治疗的情况下怀孕。使用基线居住地址,我们根据美国社区调查5年估计的极端浓度指数(ICE)计算隔离。ICE的范围从-1(弱势)到1(特权)。我们在人口普查区水平上实施了ICE指标:经济隔离(ICE收入:≥10万美元vs白人/黑人:非西班牙裔白人vs非西班牙裔黑人),以及种族化的经济隔离(ICE收入+白人/黑人:非西班牙裔白人≥10万美元vs非西班牙裔黑人收入和ICE收入+白人/黑人具有生育能力,但与ICE白人/黑人相关的证据较少。例如,相对于ice收入+白人/黑人五分位数(“最特权”),四分位数、三分位数、二分位数和一分位数(“最弱势”)的FRs分别为0.92 (95% CI = 0.86-0.99)、0.84 (95% CI = 0.78-0.90)、0.84 (95% CI = 0.78-0.90)和0.79 (95% CI = 0.73-0.86)。在种族经济隔离方面生活在最不利的社区与生育能力的适度下降有关。
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Journal of Urban Health-Bulletin of the New York Academy of Medicine
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