Pub Date : 2025-01-22DOI: 10.1016/j.jtemb.2025.127605
Ziqi Chen , Junsheng Liu , Jing Ma , Xiuqiao Yu , Shusong Wang , Zhenxian Wang
The prostate gland is the largest accessory sex gland in the male reproductive system, and is recognized for its elevated zinc concentration. Recently, the incidence of prostate diseases has increased, posing a significant threat to the health of men. Increasing evidence suggests that maintaining normal prostate function requires proper zinc homeostasis. Prostate disease can cause changes in the regulation of zinc levels in the prostate. Studies have indicated that patients with prostatitis, prostate enlargement, or prostate cancer experience an imbalance in zinc homeostasis, resulting in changes in zinc levels in the body and altered distribution of zinc in tissues. Zinc prevents the malignant transformation of normal prostate tissue by blocking citric acid oxidation, inducing apoptosis, and exhibiting antioxidant activity. Therefore, studying changes in zinc homeostasis in prostate diseases is of great clinical value for diagnosing and treating these diseases. This article reviews the distribution and content of zinc in the prostate, the mechanism underlying zinc homeostasis regulation, the role of zinc homeostasis in prostate diseases, and the clinical applications of zinc.
{"title":"Role of zinc homeostasis in the prevention of prostate diseases","authors":"Ziqi Chen , Junsheng Liu , Jing Ma , Xiuqiao Yu , Shusong Wang , Zhenxian Wang","doi":"10.1016/j.jtemb.2025.127605","DOIUrl":"10.1016/j.jtemb.2025.127605","url":null,"abstract":"<div><div>The prostate gland is the largest accessory sex gland in the male reproductive system, and is recognized for its elevated zinc concentration. Recently, the incidence of prostate diseases has increased, posing a significant threat to the health of men. Increasing evidence suggests that maintaining normal prostate function requires proper zinc homeostasis. Prostate disease can cause changes in the regulation of zinc levels in the prostate. Studies have indicated that patients with prostatitis, prostate enlargement, or prostate cancer experience an imbalance in zinc homeostasis, resulting in changes in zinc levels in the body and altered distribution of zinc in tissues. Zinc prevents the malignant transformation of normal prostate tissue by blocking citric acid oxidation, inducing apoptosis, and exhibiting antioxidant activity. Therefore, studying changes in zinc homeostasis in prostate diseases is of great clinical value for diagnosing and treating these diseases. This article reviews the distribution and content of zinc in the prostate, the mechanism underlying zinc homeostasis regulation, the role of zinc homeostasis in prostate diseases, and the clinical applications of zinc.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127605"},"PeriodicalIF":3.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-20DOI: 10.1016/j.jtemb.2025.127603
Aliza Falak , Muhammad Anas , Amjid Khan , Alvina Hayat , Zeenat Shaheen , Muhammad Hamzah Saleem , Shah Fahad , Umar Masood Quraishi
Lead (Pb) toxicity impairs the growth, yield, and biochemical traits of rice, making it essential to mitigate Pb stress in soil and restore its growth and production. This study investigated the potential of ascorbic acid-coated quantum dots (AsA-QDs) in alleviating Pb stress in two rice cultivars, Japonica (JP-5) and Indica (Super Basmati), grown in pots under Pb stress (50 mg/kg as lead chloride) with AsA-QD suspensions (50 ppm and 100 ppm) as treatments. The synthesized AsA-QDs were characterized by zeta potential (-14.4 mV), particle size (472.3 nm, PDI 0.745), UV-Vis absorption peak (240 nm), FT-IR analysis revealing functional groups (carboxylic acid and alkene), and TEM showing spherical morphology (average size 9.43 nm). Pb stress reduced key traits in JP-5, including tillers per plant (11.11 %), grain yield (18.22 %), kernel weight (18.22 %), protein (40.19 %), phenolic content (59.66 %), and antioxidant capacity (17.75 %), while 50 ppm AsA-QDs improved these by 33.33 %, 5.73 %, 2.03 %, and 13.19 %, respectively. Similarly, Pb stress reduced plant height, T/P, biomass yield (BY), GY, TKW, total sugars, reducing sugars, non-reducing sugars, starch, proteins, and TPC in Super Basmati by 19.76 %, 21.43 %, 11.01 %, 11.01 %, 7.52 %, 38.09 %, 7.24 %, 13.96 %, 11.97 %, and 40.39 %, respectively, while PbQD1 improved these traits by 14.29 %, 15.49 %, 9.25 %, 109.52 %, 8.31 %, 31.72 %, 25.91 %, and 7.075 %, respectively. The findings demonstrate that AsA-QDs effectively mitigate Pb toxicity by reducing oxidative stress, enhancing growth parameters, and restoring yield components, establishing them as a promising nanomaterial for sustainable crop resilience under Pb stress.
{"title":"Efficacy of ascorbic acid coated quantum dots in alleviating lead-induced oxidative damage and enhancing growth parameters in rice (Oryza sativa L.) for sustainable cultivation","authors":"Aliza Falak , Muhammad Anas , Amjid Khan , Alvina Hayat , Zeenat Shaheen , Muhammad Hamzah Saleem , Shah Fahad , Umar Masood Quraishi","doi":"10.1016/j.jtemb.2025.127603","DOIUrl":"10.1016/j.jtemb.2025.127603","url":null,"abstract":"<div><div>Lead (Pb) toxicity impairs the growth, yield, and biochemical traits of rice, making it essential to mitigate Pb stress in soil and restore its growth and production. This study investigated the potential of ascorbic acid-coated quantum dots (AsA-QDs) in alleviating Pb stress in two rice cultivars, Japonica (JP-5) and Indica (Super Basmati), grown in pots under Pb stress (50 mg/kg as lead chloride) with AsA-QD suspensions (50 ppm and 100 ppm) as treatments. The synthesized AsA-QDs were characterized by zeta potential (-14.4 mV), particle size (472.3 nm, PDI 0.745), UV-Vis absorption peak (240 nm), FT-IR analysis revealing functional groups (carboxylic acid and alkene), and TEM showing spherical morphology (average size 9.43 nm). Pb stress reduced key traits in JP-5, including tillers per plant (11.11 %), grain yield (18.22 %), kernel weight (18.22 %), protein (40.19 %), phenolic content (59.66 %), and antioxidant capacity (17.75 %), while 50 ppm AsA-QDs improved these by 33.33 %, 5.73 %, 2.03 %, and 13.19 %, respectively. Similarly, Pb stress reduced plant height, T/P, biomass yield (BY), GY, TKW, total sugars, reducing sugars, non-reducing sugars, starch, proteins, and TPC in Super Basmati by 19.76 %, 21.43 %, 11.01 %, 11.01 %, 7.52 %, 38.09 %, 7.24 %, 13.96 %, 11.97 %, and 40.39 %, respectively, while PbQD1 improved these traits by 14.29 %, 15.49 %, 9.25 %, 109.52 %, 8.31 %, 31.72 %, 25.91 %, and 7.075 %, respectively. The findings demonstrate that AsA-QDs effectively mitigate Pb toxicity by reducing oxidative stress, enhancing growth parameters, and restoring yield components, establishing them as a promising nanomaterial for sustainable crop resilience under Pb stress.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127603"},"PeriodicalIF":3.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-20DOI: 10.1016/j.jtemb.2025.127604
Fabiana da Silva Lima , Marina Quintas dos Santos , Edson Naoto Makiyama , Christian Hoffmann , Ricardo Ambrósio Fock
Magnesium (Mg2+) is essential for life, and low levels impair immune function, promote chronic inflammation, and influence the intestinal microbiome, with the peritoneal cavity serving as a site for direct interaction between the cavity and intestinal contents, including the microbiota. This study investigates the effects of a Mg2+-restricted diet on peritoneal immune cells and its interplay with the intestinal microbiome. Male C57BL/6NTaq mice were divided into three groups: control, restricted, and restored. The control group received a diet containing 500 mg Mg2+/kg, the restricted group received a diet with 50 mg Mg2+/kg for four weeks, and the restored group first received the restricted diet for four weeks, followed by the control diet supplemented with 0.5 g MgCl₂ per liter of water for an additional four weeks. Results showed Mg2+ restriction did not affect body weight, food intake, or water consumption but induced hypomagnesemia, reversible upon dietary restoration. Mg2+ deficiency increased in neutrophils numbers in the blood and peritoneal cavity, indicating an inflammatory response. Gene expression analysis in peritoneal mononuclear cells revealed elevated levels of Nfkb, Stat1 and Stat3, suggesting heightened inflammatory signaling. Additionally, cytokine expression analysis showed increased levels of Tnfa, Il1b and Il10, but not Il6, in Mg2+-restricted group. The intestinal microbiome of Mg2+-restricted mice exhibited increased alpha diversity, with changes in taxa abundance, including an increase in Romboutsia ilealis and a decrease in the Oscillospiraceae and Lachnospiraceae. Mg2+ deficiency significantly affects some immune functions and gut microbiota, highlighting the importance of Mg²+ in maintaining the gut health.
{"title":"The essential role of magnesium in immunity and gut health: Impacts of dietary magnesium restriction on peritoneal cells and intestinal microbiome","authors":"Fabiana da Silva Lima , Marina Quintas dos Santos , Edson Naoto Makiyama , Christian Hoffmann , Ricardo Ambrósio Fock","doi":"10.1016/j.jtemb.2025.127604","DOIUrl":"10.1016/j.jtemb.2025.127604","url":null,"abstract":"<div><div>Magnesium (Mg<sup>2+</sup>) is essential for life, and low levels impair immune function, promote chronic inflammation, and influence the intestinal microbiome, with the peritoneal cavity serving as a site for direct interaction between the cavity and intestinal contents, including the microbiota. This study investigates the effects of a Mg<sup>2+</sup>-restricted diet on peritoneal immune cells and its interplay with the intestinal microbiome. Male C57BL/6NTaq mice were divided into three groups: control, restricted, and restored. The control group received a diet containing 500 mg Mg<sup>2+</sup>/kg, the restricted group received a diet with 50 mg Mg<sup>2+</sup>/kg for four weeks, and the restored group first received the restricted diet for four weeks, followed by the control diet supplemented with 0.5 g MgCl₂ per liter of water for an additional four weeks. Results showed Mg<sup>2+</sup> restriction did not affect body weight, food intake, or water consumption but induced hypomagnesemia, reversible upon dietary restoration. Mg<sup>2+</sup> deficiency increased in neutrophils numbers in the blood and peritoneal cavity, indicating an inflammatory response. Gene expression analysis in peritoneal mononuclear cells revealed elevated levels of <em>Nfkb</em>, <em>Stat1</em> and <em>Stat3</em>, suggesting heightened inflammatory signaling. Additionally, cytokine expression analysis showed increased levels of <em>Tnfa</em>, <em>Il1b</em> and <em>Il10</em>, but not <em>Il6</em>, in Mg<sup>2+</sup>-restricted group. The intestinal microbiome of Mg<sup>2+</sup>-restricted mice exhibited increased alpha diversity, with changes in taxa abundance, including an increase in <em>Romboutsia ilealis</em> and a decrease in the <em>Oscillospiraceae</em> and <em>Lachnospiraceae</em>. Mg<sup>2+</sup> deficiency significantly affects some immune functions and gut microbiota, highlighting the importance of Mg²<sup>+</sup> in maintaining the gut health.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127604"},"PeriodicalIF":3.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1016/j.jtemb.2025.127601
Jesse Bertinato , Philip Griffin , Cunye Qiao , Deborah Cavalcanti , Louise Ghesquière , Emmanuel Bujold
Background
Adequate maternal iodine intake is important for fetal brain development. Based on iodine intakes of non-pregnant females of reproductive age from the Canadian Health Measures Survey (2016 −2017) it can be extrapolated that most pregnant females in Canada will not meet iodine requirements without supplementation.
Objectives
To assess iodine intakes of 500 pregnant, nulliparous females from Québec, Canada and report on use of multivitamin/mineral (MVM) supplements and coverage of iodized salt.
Methods
Duplicate spot urine samples were collected at 10.1 −14.9 weeks (T1) and 19.7 −24.9 weeks (T2) of gestation. Median urinary iodine concentrations (UIC) were compared with WHO/UNICEF/ICCIDD reference ranges. Daily iodine intakes were calculated from UIC using a formula that corrects for urine dilution using creatinine and accounts for urinary iodine excretion rate. Usual (adjusted for within-person variation) iodine intakes were estimated from duplicate daily intake measurements (T1 and T2 measures) using the National Cancer Institute method. Prevalence of inadequate or excessive intakes were determined from usual intakes by the Estimated Average Requirement (EAR) or Tolerable Upper Intake Level (UL) cut-point method, respectively.
Results
Females (median: 30.1 years) were mostly white race (94.4 %), highly educated and consumed iodized salt (92 %). Median UIC at T1 (136 µg/L, IQR: 71 −230) was lower (p<0.001) than at T2 (193 µg/L, IQR: 112 −390). Almost all females used a MVM supplement (98.2 %) with 35.6 % starting supplementation preconception and 0.6 %, 28.4 %, 19.8 %, 7.2 % and 6.0 % starting 1 −2 weeks, 3 −4 weeks, 5 −8 weeks, 8 −12 weeks and > 12 weeks postconception, respectively. Almost all (99 %, 95 % CI: 98, 100) had usual iodine intakes ≥EAR and ≤UL.
Conclusions
Prevalence of inadequate or excessive usual iodine intakes was low. However, about two-thirds of females started MVM supplementation postconception and median UIC at T1 was below the adequate range of 150 −249 µg/L.
{"title":"Iodine intakes of pregnant females from Québec, Canada","authors":"Jesse Bertinato , Philip Griffin , Cunye Qiao , Deborah Cavalcanti , Louise Ghesquière , Emmanuel Bujold","doi":"10.1016/j.jtemb.2025.127601","DOIUrl":"10.1016/j.jtemb.2025.127601","url":null,"abstract":"<div><h3>Background</h3><div>Adequate maternal iodine intake is important for fetal brain development. Based on iodine intakes of non-pregnant females of reproductive age from the Canadian Health Measures Survey (2016 −2017) it can be extrapolated that most pregnant females in Canada will not meet iodine requirements without supplementation.</div></div><div><h3>Objectives</h3><div>To assess iodine intakes of 500 pregnant, nulliparous females from Québec, Canada and report on use of multivitamin/mineral (MVM) supplements and coverage of iodized salt.</div></div><div><h3>Methods</h3><div>Duplicate spot urine samples were collected at 10.1 −14.9 weeks (T1) and 19.7 −24.9 weeks (T2) of gestation. Median urinary iodine concentrations (UIC) were compared with WHO/UNICEF/ICCIDD reference ranges. Daily iodine intakes were calculated from UIC using a formula that corrects for urine dilution using creatinine and accounts for urinary iodine excretion rate. Usual (adjusted for within-person variation) iodine intakes were estimated from duplicate daily intake measurements (T1 and T2 measures) using the National Cancer Institute method. Prevalence of inadequate or excessive intakes were determined from usual intakes by the Estimated Average Requirement (EAR) or Tolerable Upper Intake Level (UL) cut-point method, respectively.</div></div><div><h3>Results</h3><div>Females (median: 30.1 years) were mostly white race (94.4 %), highly educated and consumed iodized salt (92 %). Median UIC at T1 (136 µg/L, IQR: 71 −230) was lower (p<0.001) than at T2 (193 µg/L, IQR: 112 −390). Almost all females used a MVM supplement (98.2 %) with 35.6 % starting supplementation preconception and 0.6 %, 28.4 %, 19.8 %, 7.2 % and 6.0 % starting 1 −2 weeks, 3 −4 weeks, 5 −8 weeks, 8 −12 weeks and > 12 weeks postconception, respectively. Almost all (99 %, 95 % CI: 98, 100) had usual iodine intakes ≥EAR and ≤UL.</div></div><div><h3>Conclusions</h3><div>Prevalence of inadequate or excessive usual iodine intakes was low. However, about two-thirds of females started MVM supplementation postconception and median UIC at T1 was below the adequate range of 150 −249 µg/L.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127601"},"PeriodicalIF":3.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1016/j.jtemb.2025.127600
Fakhira Khalid, Hamda Azmat
Background
Arsenic emerges as most potent hazardous element ranked as number one in ATSDR (Agency for Toxic Substances and Disease Registry) list, can easily accumulate in fish, transported to humans via consumption and affect humans and aquatic organisms. Considering above, current experiment designed to evaluate cyto-genotoxicity and histological alterations induced by arsenic in Labeo rohita used as an animal model.
Methods
By applying complete randomized design sampling acclimatized individuals of Labeo rohita (10 batches of 10 each with triplicates) were exposed to nine definitive doses (12, 14, 16, 18, 20, 22, 24, 26 and 28 mgL−1) of arsenic in glass aquaria to determine 96-h lethal concentration (LC50) of arsenic. Control group without arsenic was also run simultaneously. After 96-h exposure various histo-biochemical parameters were evaluated in all experimental groups.
Results
The 96-h lethal concentration of arsenic was found to be 20.2 mgL−1. Upon arsenic exposure, oxidative stress biomakers: catalase (CAT), superoxide dismutase (SOD) and lipid per oxidation (LPO) and accumulation of arsenic in all targeted organs were considerably (p ≤ 0.05) increased in dose dependent manner and in comparison, to unexposed (control) group. Serum liver function enzymes, immunological status (albumin, globulin and total protein), cortisol level and cytochrome P450 gene expression remarkably (p ≤ 0.05) altered on arsenic exposure. The histological analysis also showed destructive alterations on exposure to arsenic in gill and liver tissues.
Conclusion
These results confirmed that exposure of arsenic led to pronounced deleterious alterations in Labeo rohita and evidencing the need for monitoring alarmingly increasing concentration of arsenic.
{"title":"Acute arsenic exposure induces cyto-genotoxicity and histological alterations in Labeo rohita","authors":"Fakhira Khalid, Hamda Azmat","doi":"10.1016/j.jtemb.2025.127600","DOIUrl":"10.1016/j.jtemb.2025.127600","url":null,"abstract":"<div><h3>Background</h3><div>Arsenic emerges as most potent hazardous element ranked as number one in ATSDR (Agency for Toxic Substances and Disease Registry) list, can easily accumulate in fish, transported to humans via consumption and affect humans and aquatic organisms. Considering above, current experiment designed to evaluate cyto-genotoxicity and histological alterations induced by arsenic in <em>Labeo rohita</em> used as an animal model<em>.</em></div></div><div><h3>Methods</h3><div>By applying complete randomized design sampling acclimatized individuals of <em>Labeo rohita</em> (10 batches of 10 each with triplicates) were exposed to nine definitive doses (12, 14, 16, 18, 20, 22, 24, 26 and 28 mgL<sup>−1</sup>) of arsenic in glass aquaria to determine 96-h lethal concentration (LC<sub>50</sub>) of arsenic. Control group without arsenic was also run simultaneously. After 96-h exposure various histo-biochemical parameters were evaluated in all experimental groups.</div></div><div><h3>Results</h3><div>The 96-h lethal concentration of arsenic was found to be 20.2 mgL<sup>−1</sup>. Upon arsenic exposure, oxidative stress biomakers: catalase (CAT), superoxide dismutase (SOD) and lipid per oxidation (LPO) and accumulation of arsenic in all targeted organs were considerably (p ≤ 0.05) increased in dose dependent manner and in comparison, to unexposed (control) group. Serum liver function enzymes, immunological status (albumin, globulin and total protein), cortisol level and cytochrome P450 gene expression remarkably (p ≤ 0.05) altered on arsenic exposure. The histological analysis also showed destructive alterations on exposure to arsenic in gill and liver tissues.</div></div><div><h3>Conclusion</h3><div>These results confirmed that exposure of arsenic led to pronounced deleterious alterations in <em>Labeo rohita</em> and evidencing the need for monitoring alarmingly increasing concentration of arsenic.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127600"},"PeriodicalIF":3.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1016/j.jtemb.2025.127602
Lanxin Fan , Xueqing Gong , Hongling Jia
Background
This study aimed to investigate the potential association between magnesium depletion score (MDS), a novel assessment of magnesium status in vivo, and all-cause and cardiovascular mortality in asthma patients.
Methods
Using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, 4757 asthmatics were included in the study and were categorized into four groups based on their MDS levels (MDS=0, MDS=1, MDS=2, and MDS≥3). Survival differences between the different MDS groups were analysed using Kaplan-Meier curves, and weighted multivariate Cox regression models assessed the relationship between MDS and mortality. In addition, non-linear relationships between MDS and all-cause and cardiovascular mortality were explored using restricted cubic spline (RCS) regression models, and subgroup analyses were performed to validate the results.
Results
Kaplan-Meier curves showed that both all-cause and cardiovascular mortality were significantly higher in the group with higher levels of MDS (P < 0.001). After controlling for all confounders, asthmatics in the higher MDS group faced a higher risk of death compared with the lower MDS group, as evidenced by a 3.29-fold increase in all-cause mortality (95 % CI: 2.05, 5.29) and a 4.68-fold increase in cardiovascular mortality (95 % CI: 1.77, 12.35). Fully adjusted Cox regression models further confirmed the significant positive association of high MDS with the risk of all-cause and cardiovascular mortality.RCS plots revealed a linear dose-response relationship between MDS and mortality. In the subgroup analyses, no interaction factors other than cardiovascular disease were found to significantly influence the relationship between MDS and mortality.
Conclusion
Higher levels of MDS independently predicted the risk of mortality, especially cardiovascular mortality, in US adults with asthma. Therefore, the MDS may become a cost-effective and widely applicable prognostic assessment tool for asthma, providing an important reference for clinical decision-making and patient management.
{"title":"Relationship between the magnesium depletion score and all-cause and cardiovascular mortality among asthma patients: A Study based on the NHANES population from 2005–2018","authors":"Lanxin Fan , Xueqing Gong , Hongling Jia","doi":"10.1016/j.jtemb.2025.127602","DOIUrl":"10.1016/j.jtemb.2025.127602","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the potential association between magnesium depletion score (MDS), a novel assessment of magnesium status in vivo, and all-cause and cardiovascular mortality in asthma patients.</div></div><div><h3>Methods</h3><div>Using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, 4757 asthmatics were included in the study and were categorized into four groups based on their MDS levels (MDS=0, MDS=1, MDS=2, and MDS≥3). Survival differences between the different MDS groups were analysed using Kaplan-Meier curves, and weighted multivariate Cox regression models assessed the relationship between MDS and mortality. In addition, non-linear relationships between MDS and all-cause and cardiovascular mortality were explored using restricted cubic spline (RCS) regression models, and subgroup analyses were performed to validate the results.</div></div><div><h3>Results</h3><div>Kaplan-Meier curves showed that both all-cause and cardiovascular mortality were significantly higher in the group with higher levels of MDS (P < 0.001). After controlling for all confounders, asthmatics in the higher MDS group faced a higher risk of death compared with the lower MDS group, as evidenced by a 3.29-fold increase in all-cause mortality (95 % CI: 2.05, 5.29) and a 4.68-fold increase in cardiovascular mortality (95 % CI: 1.77, 12.35). Fully adjusted Cox regression models further confirmed the significant positive association of high MDS with the risk of all-cause and cardiovascular mortality.RCS plots revealed a linear dose-response relationship between MDS and mortality. In the subgroup analyses, no interaction factors other than cardiovascular disease were found to significantly influence the relationship between MDS and mortality.</div></div><div><h3>Conclusion</h3><div>Higher levels of MDS independently predicted the risk of mortality, especially cardiovascular mortality, in US adults with asthma. Therefore, the MDS may become a cost-effective and widely applicable prognostic assessment tool for asthma, providing an important reference for clinical decision-making and patient management.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127602"},"PeriodicalIF":3.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1016/j.jtemb.2025.127599
Yu Liu , Ye Liu , Liping Shi , Xue Zhang , Kunmei Liu , Shulan He
Background
Alzheimer's disease (AD) is a neurodegenerative disorder that primarily affects older adults. Selenium, an essential micronutrient for humans, plays a crucial role in the body's normal physiological and metabolic processes. A long-term deficiency in selenium intake can lead to various diseases and even contribute to the ageing process. This study aims to explore the ameliorative effect of selenium on cognitive impairment in 3 × Tg-AD mice and to determine if its effects are related to the BDNF/TrkB pathway.
Methods
We employed the APP/PS1/tau 3 × Tg-AD mouse model for dietary selenium intervention. Behavioural experiments were conducted to assess learning and memory. Additionally, we measured selenium and GSH-Px levels in whole blood and brain tissue. Neuronal apoptosis in the hippocampus was observed using transmission electron microscopy. The expressions of Aβ, P-tau, BDNF, TrkB, and CREB were measured via RT-qPCR, while the expressions of Aβ, P-tau, BDNF, TrkB, p-CREB, and CREB were quantified using Western blot analysis.
Results
Our findings indicate that selenium supplementation can improve spatial learning and memory deficiencies in 3 × Tg-AD mice. Selenium supplementation increased selenium and GSH-Px levels in the brain tissue of 3 × Tg-AD mice and significantly enhanced neuronal conditions. Furthermore, the expression levels of proteins related to the BDNF/TrkB pathway significantly increased following selenium supplementation.
Conclusions
Our study demonstrates that selenium can ameliorate memory impairment in 3 × Tg-AD mice by activating the BDNF/TrkB pathway.
{"title":"Selenium ameliorates cognitive impairment through activating BDNF/TrkB pathway","authors":"Yu Liu , Ye Liu , Liping Shi , Xue Zhang , Kunmei Liu , Shulan He","doi":"10.1016/j.jtemb.2025.127599","DOIUrl":"10.1016/j.jtemb.2025.127599","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease (AD) is a neurodegenerative disorder that primarily affects older adults. Selenium, an essential micronutrient for humans, plays a crucial role in the body's normal physiological and metabolic processes. A long-term deficiency in selenium intake can lead to various diseases and even contribute to the ageing process. This study aims to explore the ameliorative effect of selenium on cognitive impairment in 3 × Tg-AD mice and to determine if its effects are related to the BDNF/TrkB pathway.</div></div><div><h3>Methods</h3><div>We employed the APP/PS1/tau 3 × Tg-AD mouse model for dietary selenium intervention. Behavioural experiments were conducted to assess learning and memory. Additionally, we measured selenium and GSH-Px levels in whole blood and brain tissue. Neuronal apoptosis in the hippocampus was observed using transmission electron microscopy. The expressions of Aβ, P-tau, BDNF, TrkB, and CREB were measured via RT-qPCR, while the expressions of Aβ, P-tau, BDNF, TrkB, p-CREB, and CREB were quantified using Western blot analysis.</div></div><div><h3>Results</h3><div>Our findings indicate that selenium supplementation can improve spatial learning and memory deficiencies in 3 × Tg-AD mice. Selenium supplementation increased selenium and GSH-Px levels in the brain tissue of 3 × Tg-AD mice and significantly enhanced neuronal conditions. Furthermore, the expression levels of proteins related to the BDNF/TrkB pathway significantly increased following selenium supplementation.</div></div><div><h3>Conclusions</h3><div>Our study demonstrates that selenium can ameliorate memory impairment in 3 × Tg-AD mice by activating the BDNF/TrkB pathway.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127599"},"PeriodicalIF":3.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-14DOI: 10.1016/j.jtemb.2025.127597
Ali Hamza , Sayda Snober Fatima Zadi , Muhammad Zaid Salar , Muhammad Umar Ijaz , Khalid A. Al-Ghanim , Ayesha Ishtiaq
Background
Cadmium (Cd) is a toxic heavy metal present in environment that has potential to instigate renal toxicity. Didymin (DDM) is a natural flavone, which shows anti-oxidant, anti-inflammatory and antiapoptotic nature. Therefore, the current study was formulated to appraise attenuative potential of DDM against Cd instigated nephrotoxicity.
Methods
Forty-eight albino rats were divided into four equal groups, including control, Cd (5 mg/kg) inebriated group, Cd + DDM (5 mg/kg + 1 mg/kg) concurrent-treated group, as well as DDM (1 mg/kg) alone treated group. The trial was conducted for 30 days and then the rats were anesthetized, decapitated and further analyses were performed.
Results
The results demonstrated that Cd treatment lowered the expressions of Nrf-2 and its anti-oxidant genes while escalating Keap-1 expression. Cd exposure downregulated the activities of antioxidant enzymes, SOD, GSR, CAT, HO-1, GPx, GST & GSH contents, while the levels of MDA and ROS were escalated. Furthermore, Cd exposure lowered the levels of creatinine clearance and albumin, while increasing the levels of urobilinogen, urinary proteins, urea, creatinine, NGAL and KIM-1. Moreover, Cd intoxication also augmented the levels of inflammatory indices including, IL-1β, NF-κB, TNF-α, IL-6 and COX-2. Additionally, Cd exposure reduced the expressions of Bcl-2, while increasing Bax and caspase-3 expressions. In addition to this, Cd also provoked multiple histological injuries in the renal tissues of the rats. However, DDM supplementation markedly recovered the renal tissues from the Cd induced damages.
Conclusion
In conclusion, DDM protected the renal tissues from Cd-provoked damages due to its antiapoptotic, anti-oxidant and anti-inflammatory efficacy.
{"title":"Mitigative effects of didymin against cadmium-induced renal injury via regulating Nrf-2/Keap-1, apoptosis, inflammation and oxidative stress","authors":"Ali Hamza , Sayda Snober Fatima Zadi , Muhammad Zaid Salar , Muhammad Umar Ijaz , Khalid A. Al-Ghanim , Ayesha Ishtiaq","doi":"10.1016/j.jtemb.2025.127597","DOIUrl":"10.1016/j.jtemb.2025.127597","url":null,"abstract":"<div><h3>Background</h3><div>Cadmium (Cd) is a toxic heavy metal present in environment that has potential to instigate renal toxicity. Didymin (DDM) is a natural flavone, which shows anti-oxidant, anti-inflammatory and antiapoptotic nature. Therefore, the current study was formulated to appraise attenuative potential of DDM against Cd instigated nephrotoxicity.</div></div><div><h3>Methods</h3><div>Forty-eight albino rats were divided into four equal groups, including control, Cd (5 mg/kg) inebriated group, Cd + DDM (5 mg/kg + 1 mg/kg) concurrent-treated group, as well as DDM (1 mg/kg) alone treated group. The trial was conducted for 30 days and then the rats were anesthetized, decapitated and further analyses were performed.</div></div><div><h3>Results</h3><div>The results demonstrated that Cd treatment lowered the expressions of Nrf-2 and its anti-oxidant genes while escalating Keap-1 expression. Cd exposure downregulated the activities of antioxidant enzymes, SOD, GSR, CAT, HO-1, GPx, GST & GSH contents, while the levels of MDA and ROS were escalated. Furthermore, Cd exposure lowered the levels of creatinine clearance and albumin, while increasing the levels of urobilinogen, urinary proteins, urea, creatinine, NGAL and KIM-1. Moreover, Cd intoxication also augmented the levels of inflammatory indices including, IL-1β, NF-κB, TNF-α, IL-6 and COX-2. Additionally, Cd exposure reduced the expressions of Bcl-2, while increasing Bax and caspase-3 expressions. In addition to this, Cd also provoked multiple histological injuries in the renal tissues of the rats. However, DDM supplementation markedly recovered the renal tissues from the Cd induced damages.</div></div><div><h3>Conclusion</h3><div>In conclusion, DDM protected the renal tissues from Cd-provoked damages due to its antiapoptotic, anti-oxidant and anti-inflammatory efficacy.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127597"},"PeriodicalIF":3.6,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
[CuL1–4(tmen)] is a sequence of four ternary mononuclear Schiff base copper(II) complexes that are derived from L-valine, suitable 5′-substituted-2′-hydroxyacetophenones (where the substituents are -Cl for L1, -Me for L2, -OMe for L3, and -H for L4), and tmen (where tmen-N,N,N′,N′ tetramethyl ethylenediamine). Without isolating the Schiff base ligand or producing any other intermediate products, all of the complexes were synthesised. These compounds were identified using elemental analysis, molar conductance, UV-Vis, FTIR, EPR, VSM-RT, and CD spectra. Single crystal XRD was used to characterise the structure of Complex 1. The crystalline structure exhibits a distorted square pyramidal shape wherein the Schiff base forms an axial bond with the Cu(II) ion through the ONO-donor, while the chelating ligand tmen exhibits both an equatorial and an axial mode of binding through the NN-donor atoms. Hydrogen bonding and non-covalent CH(methyl)π(phenyl) interaction are two intriguing aspects of compound 1's packing diagram. By calculating the minimum inhibitory concentration (MIC) against harmful bacteria, the synthesised complexes' antimicrobial activity was assessed. According to the bioactivity experiments, the microorganisms employed in this investigation were susceptible to the antibacterial and antifungal properties of copper(II) complexes 1–4. According to the bioactivity experiments, the microorganisms employed in this investigation were susceptible to the antibacterial and antifungal properties of copper(II) complexes 1–4.
{"title":"Synthesis, crystal structure, characterization and antimicrobial activities of ternary chiral mononuclear Schiff base copper(II) complexes","authors":"Santha Lakshmi Sundaramurthy , Kannappan Geetha , Ganesh Shanmugam , Thandapani Gomathi , Ganesan Logesh , Sekar Vijayakumar","doi":"10.1016/j.jtemb.2025.127590","DOIUrl":"10.1016/j.jtemb.2025.127590","url":null,"abstract":"<div><div>[CuL<sup>1–4</sup>(tmen)] is a sequence of four ternary mononuclear Schiff base copper(II) complexes that are derived from L-valine, suitable 5′-substituted-2′-hydroxyacetophenones (where the substituents are -Cl for L<sup>1</sup>, -Me for L<sup>2</sup>, -OMe for L<sup>3</sup>, and -H for L<sup>4</sup>), and tmen (where tmen-N,N,N′,N′ tetramethyl ethylenediamine). Without isolating the Schiff base ligand or producing any other intermediate products, all of the complexes were synthesised. These compounds were identified using elemental analysis, molar conductance, UV-Vis, FTIR, EPR, VSM-RT, and CD spectra. Single crystal XRD was used to characterise the structure of Complex 1. The crystalline structure exhibits a distorted square pyramidal shape wherein the Schiff base forms an axial bond with the Cu(II) ion through the ONO-donor, while the chelating ligand tmen exhibits both an equatorial and an axial mode of binding through the NN-donor atoms. Hydrogen bonding and non-covalent CH(methyl)<img>π(phenyl) interaction are two intriguing aspects of compound 1's packing diagram. By calculating the minimum inhibitory concentration (MIC) against harmful bacteria, the synthesised complexes' antimicrobial activity was assessed. According to the bioactivity experiments, the microorganisms employed in this investigation were susceptible to the antibacterial and antifungal properties of copper(II) complexes 1–4. According to the bioactivity experiments, the microorganisms employed in this investigation were susceptible to the antibacterial and antifungal properties of copper(II) complexes 1–4.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127590"},"PeriodicalIF":3.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/S0946-672X(24)00197-4
{"title":"FESTEM","authors":"","doi":"10.1016/S0946-672X(24)00197-4","DOIUrl":"10.1016/S0946-672X(24)00197-4","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127577"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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