Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Assessment of heavy metal levels in cow's milk and associated health risks in the vicinity of the MIDROC Laga Dambi gold mine in Ethiopia","authors":"Workineh Mengesha Fereja ,&nbsp;Chuluke Muda ,&nbsp;Abraham Alemayehu Labena","doi":"10.1016/j.jtemb.2024.127529","DOIUrl":"10.1016/j.jtemb.2024.127529","url":null,"abstract":"<div><h3>Introduction</h3><p>The possible health effects of consuming milk contaminated with heavy metals have been the subject of considerable concern worldwide.</p></div><div><h3>Objective</h3><p>The aim of this study was to determine the level of heavy metals in cow's milk in the vicinity of MIDROC Laga Dambi gold mine and to assess their possible health risks for consumers.</p></div><div><h3>Methods</h3><p>Nine composite samples were formed by aggregating 243 milk samples obtained in triplicates from 81 domestic milk-producing households. Inductively coupled plasma-optical emission spectroscopy was used to measure the amount of heavy metals after samples digestion under optimal conditions.</p></div><div><h3>Results</h3><p>The heavy metals concentrations obtained were 13.913˗7.843, 9.505˗3.589, 5.972˗3.147, 2.288˗1.851, 0.403˗0.143, 0.436˗0.128, 0.26˗0.153, 0.143˗0.048, 0.160˗ND (not detected), and 0.140˗ND mgkg⁻¹for Fe, Zn, Pb, Mn, Hg, Cr, Cd, As, Ni, and Co, respectively. Of the heavy metals identified, the levels of Pb, As, Cd, and Hg exceeded the recommended value. Based on the estimated daily intake (EDI), the total health quotient (THQ) is higher than unity even for Pb alone. It has been found that the consumption of cow milk increases the health index (HI) by 2.972. Ninety five percent of the HI in the study area was explained by the toxic heavy metals (Pb, Cd, As, and Hg) in the cow milk, which were found to be beyond the safe limit.</p></div><div><h3>Conclusion</h3><p>This demonstrates that there is a health risk to the population who consume cow’s milk sourced from the vicinity of MIDROC Laga Dambi gold mine. To safeguard the public’s health, we advised strict monitoring and legislative control for the safety of cow’s milk originating from study area.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127529"},"PeriodicalIF":3.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper excess in psychiatric disorders: a focus on mood spectrum disorders and sex","authors":"Rosanna Squitti ,&nbsp;Mauro Rongioletti ,&nbsp;Silvia Fostinelli ,&nbsp;Altea Severino ,&nbsp;Cristian Bonvicini ,&nbsp;Andrea Geviti ,&nbsp;Alessandra Martinelli ,&nbsp;Giovanni Battista Tura ,&nbsp;Roberta Ghidoni","doi":"10.1016/j.jtemb.2024.127532","DOIUrl":"10.1016/j.jtemb.2024.127532","url":null,"abstract":"<div><h3>Background</h3><p>Meta-analyses show increased copper (Cu) levels in major depression disorder. However, the association of Cu biomarkers with clinical classification in other mental health disorders has not been fully explored.</p></div><div><h3>Methods</h3><p>To this aim, we compared an extensive panel of Cu biomarkers, composed of Cu, ceruloplasmin (Cp) Cp activity, Cp specific activity, Cu not bound to ceruloplasmin (non-Cp Cu, also known as ‘free’ copper) in 171 consecutive patients affected by psychiatric disorders and in 61 healthy controls (HC) using MANOVA adjusting for the effect of sex and age, and studied their association with the clinical scale outcomes at psychiatric examination, namely Global Assessment of Functioning, Clinical Global Impression, and Brief Psychiatric Rating Scale.</p></div><div><h3>Results</h3><p>individuals with psychiatric disorders were classified as 109 patients affected by mood spectrum disorders (MSD), 20 patients with schizophrenia spectrum disorders (SSD), and 42 with personality disorders (PD). Cu and non-Cp Cu were increased in psychiatric individuals than in HC, which also differed among the patients stratified per the clinical classification, being higher in the MSD individuals. The analysis stratified for sex revealed that women from the patient group, and specifically from the MSD group, had increased levels of Cu and non-Cp Cu than healthy women, while no difference was revealed in men. A logistic regression model considering the effect of sex and age revealed that non-Cp Cu could explain 26 % increased odds of having MSD per µmol/L unit increase (OR = 1.26; p = 0.0008; 95 % CI 1.099–1.436), that reached 40 % when considering only women. This result was driven by non-Cp Cu that correctly classified 64.1 % MSD (70 % in women) individuals vs. HC in a decision tree model, with values higher than 2.1 µmol/L which could distinguish the majority of MSD patients (86.3 % MSD vs. 13.7 % HC in women). None of the biological variables under study correlated with outcomes of the clinical scales, substances, or alcohol abuse.</p></div><div><h3>Conclusion</h3><p>Current results suggest mild Cu toxicity in women with MSD, as revealed by a value of non-Cp Cu higher than 2.1 µmol/L, which can be further investigated to assess its potential diagnostic accuracy in bigger and longitudinal cohorts.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127532"},"PeriodicalIF":3.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0946672X24001524/pdfft?md5=e008593a0ba1378aa5ff35527a511a9c&pid=1-s2.0-S0946672X24001524-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between single and mixed trace elements exposure in systemic lupus erythematosus: A case-control study","authors":"Rong-Gui Huang ,&nbsp;Kai-Di Li ,&nbsp;Hong Wu ,&nbsp;Yi-Yu Wang ,&nbsp;Ya Xu ,&nbsp;Xue Jin ,&nbsp;Yu-Jie Du ,&nbsp;Yi-Yuan Wang ,&nbsp;Jing Wang ,&nbsp;Zhang-Wei Lu ,&nbsp;Bao-Zhu Li","doi":"10.1016/j.jtemb.2024.127524","DOIUrl":"10.1016/j.jtemb.2024.127524","url":null,"abstract":"<div><h3>Background</h3><p>Recent studies have shown an association between trace elements and systemic lupus erythematosus (SLE), but the relationship between trace elements and SLE is still unclear. This study aims to determine the distribution of plasma trace elements in newly diagnosed SLE patients and the association between these essential and toxic element mixtures and SLE.</p></div><div><h3>Methods</h3><p>In total, 110 SLE patients and 110 healthy controls were included. Blood samples were collected. 15 plasma trace elements were quantified using an inductively coupled plasma mass spectrometer (ICP-MS). Multivariate logistic regression, restricted cubic spline (RCS), weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) are used to analyze the association between single and mixed exposure of elements and SLE.</p></div><div><h3>Results</h3><p>The logistic regression model shows that, plasma lithium (Li) [OR (95 % CI): 1.963 (1.49–2.586)], vanadium (V) [OR (95 % CI): 2.617(1.645–4.166)] and lead (Pb) [OR (95 % CI): 1.603(1.197–2.145)] were positively correlated with SLE, while selenium (Se) [OR (95 % CI): 0.055(0.019–0.157)] and barium (Ba) [OR (95 % CI): 0.792(0.656–0.957)] had been identified as protective factors for SLE. RCS results showed a non-linear correlation between the elements Li, V, Ni, copper, Se, rubidium and SLE. In addition, WQS regression, qgcomp, and BKMR models consistently revealed significant positive effects of plasma Li and Pb on SLE, as well as significant negative effects of plasma Se.</p></div><div><h3>Conclusions</h3><p>Exposure to heavy metals such as Li and Pb is significantly positively correlated with SLE, but Se may be protective factors for SLE. In addition, there is a nonlinear correlation between the elements Li and Se and SLE, and there are complex interactions between the elements. In the future, larger populations and prospective studies are needed to confirm these associations.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127524"},"PeriodicalIF":3.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The smallest traces of crime: Trace elements in forensic science","authors":"Agnieszka Kosińska ,&nbsp;Marcella Mrózek ,&nbsp;Marta Łopyta-Mirocha ,&nbsp;Marcin Tomsia","doi":"10.1016/j.jtemb.2024.127527","DOIUrl":"10.1016/j.jtemb.2024.127527","url":null,"abstract":"<div><h3>Background</h3><p>Securing the evidence in various investigative situations is often associated with trace analysis, including fingerprints or blood groups. However, when classic and conventional methods fail, trace elements, such as copper, zinc, fluorine, and many others found in exceedingly insignificant amounts in organisms, may prove useful and effective.</p></div><div><h3>Methods</h3><p>The presented work reviews articles published between 2003 and 2023, describing the use of trace elements and the analytical methods employed for their analysis in forensic medicine and related sciences.</p></div><div><h3>Results &amp; conclusion</h3><p>Trace elements can be valuable as traces collected at crime scenes and during corpse examination, aiding in determining characteristics like the sex or age of the deceased. Additionally, trace elements levels in the body can serve as alcohol or drug poisoning markers. In traumatology, trace elements enable the identification of various instruments and the injuries caused by their use.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127527"},"PeriodicalIF":3.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0946672X24001470/pdfft?md5=29092a086ff3882d8a4812b379cf1a21&pid=1-s2.0-S0946672X24001470-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring serum trace element shifts: Implications for cervical intraepithelial neoplasia","authors":"Jovana Kocić ,&nbsp;Nebojša Zečević ,&nbsp;Jovana Jagodić ,&nbsp;Daniela Ardalić ,&nbsp;Željko Miković ,&nbsp;Jelena Kotur-Stevuljević ,&nbsp;Dragan Manojlović ,&nbsp;Aleksandar Stojsavljević","doi":"10.1016/j.jtemb.2024.127531","DOIUrl":"10.1016/j.jtemb.2024.127531","url":null,"abstract":"<div><h3>Background</h3><p>Cervical intraepithelial neoplasia (CIN) represents a premalignant state presumably related to perturbations in circulating levels of trace elements.</p></div><div><h3>Materials and methods</h3><p>Employing inductively coupled plasma mass spectrometry (ICP-MS), we quantified essential and toxic trace elements in the sera of 60 women diagnosed with CIN and 60 age-matched healthy counterparts.</p></div><div><h3>Results</h3><p>Our investigation revealed a noteworthy higher levels in serum of Mn, Zn, and Pb, as well as lower levels in Ni, Se, Rb, and Mo levels within the CIN cohort. Levels of Mn, Zn, and Pb were higher by approximately 5.5-fold, 3.0-fold, and 7.5-fold, respectively, while Mo levels exhibited an approximate 4.5-fold reduction in CIN sera compared to the control group. While the study provided valuable insights into trace element variations, it’s important to note that the adult Serbian population is considered Zn-deficient, so the Zn data should be interpreted with caution. Age stratification (30–40 vs. 40–50 vs. 50–60 years), smoking status (smokers vs. nonsmokers), and CIN severity (CIN 2 vs. CIN 3) yielded no significant disparities in elemental profiles. Among the 10 proposed ratios, 5 demonstrated a significant surge in CIN sera relative to controls: Mn/Se, Mn/Mo, Zn/Se, Zn/Mo, and Se/Mo. Correlation analysis of trace element levels revealed a predominantly consistent pattern between CIN cases and healthy subjects, except for Zn and its negative correlations (antagonistic interactions) with other analyzed trace elements.</p></div><div><h3>Conclusion</h3><p>Our findings underscore differences in serum levels of specific trace elements in CIN cases versus controls, implicating their potential involvement in the underlying pathophysiological cascades culminating in cervical neoplasms.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127531"},"PeriodicalIF":3.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of dietary selenium nanoparticles and vitamin C improve growth performance, immune response, and antioxidant status of juvenile common carp (Cyprinus carpio)","authors":"Narges Saremi,&nbsp;Saeed Keyvanshokooh,&nbsp;Seyed Mohammad Mousavi,&nbsp;Hamid Mohammadiazarm","doi":"10.1016/j.jtemb.2024.127530","DOIUrl":"10.1016/j.jtemb.2024.127530","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to investigate the synergistic effects of dietary selenium nanoparticles (Se-NPs) and vitamin C (VC) on growth, body composition, antioxidant defense, immunity, and serum biochemical indexes of common carp (<em>Cyprinus carp</em>) juveniles.</p></div><div><h3>Methodology</h3><p>The test diets were supplemented with three levels of Se-NPs (0, 0.5, and 1 mg/Kg) and three levels of VC (0, 500, and 1000 mg/Kg): the basal diet without supplemental Se-NPs and VC (VC₀SeNPs₀; control), 0.5 mg Se-NPs /Kg (VC₀SeNPs_0.5), 1 mg Se-NPs /Kg (VC₀SeNPs₁), 500 mg VC/Kg (VC₅₀₀SeNPs₀), 1000 mg VC/Kg (VC₁₀₀₀SeNPs₀), 500 mg VC/Kg and 0.5 mg Se-NPs (VC₅₀₀SeNPs_0.5), 1000 mg VC/Kg and 0.5 mg Se-NPs (VC₁₀₀₀SeNPs_0.5), 500 mg VC/Kg and 1 mg Se-NPs (VC₅₀₀SeNPs₁), 1000 mg VC/Kg and 1 mg Se-NPs (VC₁₀₀₀SeNPs₁). The fish were randomly divided into nine experimental groups in triplicate tanks per treatment and fed on their respective diets for 60 days.</p></div><div><h3>Results</h3><p>The findings displayed that fish fed with VC₅₀₀SeNPs₁ and VC₅₀₀SeNPs_0.5 diets had significantly (<em>P</em> &lt; 0.05) higher specific growth rates when compared to other groups. The lowest feed conversion ratio was detected in the VC₁₀₀₀SeNPs₁ group and the highest in the control group (<em>P</em> &lt; 0.05). VC, Se-NPs, and their interaction had no significant effect on serum malondialdehyde, ACH50, and IgM (<em>P</em> &gt; 0.05). However, the best parameters associated with antioxidant capacity (higher serum levels of superoxide dismutase and total reduced glutathione) and physiological status (higher concentration of serum globulin and lower amounts of aspartate aminotransferase and lactate dehydrogenase) belonged to the VC₁₀₀₀SeNPs₁ and VC₅₀₀SeNPs₁ groups. The results suggest that the Se-NPs and VC combination more efficiently influence the common carp’s growth performance, antioxidant status, immunity, and physiological parameters.</p></div><div><h3>Conclusion</h3><p>Overall, the diet enriched with 500 mg VC and 1 mg Se-NPs /Kg (VC₅₀₀SeNPs₁) is suitable for boosting the growth and immunity of common carp.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127530"},"PeriodicalIF":3.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated daily intake and health risk assessment of total and organic selenium in crops across areas with different selenium levels","authors":"Litao Hao ,&nbsp;Yangchun Han ,&nbsp;Shixi Zhang ,&nbsp;Yingjie Luo ,&nbsp;Kunli Luo ,&nbsp;Lijun Zhang ,&nbsp;Weiqiang Chen","doi":"10.1016/j.jtemb.2024.127525","DOIUrl":"10.1016/j.jtemb.2024.127525","url":null,"abstract":"<div><h3>Background</h3><p>The health risk of Se has gained significant attention. Previous studies mainly focused on the health risk of total Se in high-Se area. Less attention has been paid to the health risk of organic selenium in areas with varying selenium levels.</p></div><div><h3>Methods</h3><p>A total number of 109 crop samples (edible parts) were collected in Langao County, Shannxi Province, China from 2018 to 2020, including 42 corn, 18 rice, 9 sweet potato, 25 potato, 12 radish, and 3 eggplant samples. The hydride generation atomic fluorescence spectrometry (HG-AFS) method was used to determine the total and organic Se contents.</p></div><div><h3>Result and conclusion</h3><p>(1) Corn (2.82 mg/kg), rice (0.44 mg/kg), potato (6.56 mg/kg), and eggplant (0.77 mg/kg) in high-Se area, as well as sweet potato (1.07 mg/kg) and radish (4.28 mg/kg) in medium-Se area, exhibited the highest total Se content among all crops in this county, and 5–328 times higher than the values of Se-enriched standard (2) The average daily intake of total/organic Se of residents in high-Se area reached 676/449 μg/day, which was 1–4 times higher than levels observed in medium-Se area (419/257 μg/day) and low-Se area (196/128 μg/day). The organic Se daily intakes from dietary combinations of rice + radish and rice + eggplant in high-Se area lower than 400 μg/day, which could be safely consumed. The organic Se daily intakes from dietary combinations of sweet potato + radish and sweet + eggplant in medium-Se area higher than 400 μg/day, which could not be safely consumed. The total / organic Se daily intakes of all dietary combinations in low-Se area lower than 400 μg/day, which could be safely consumed. (3) The health risk associated with crops might be overestimated due to the higher non-carcinogenic risk attributed to total Se compared to organic Se. The present study demonstrated that daily intake and health risk of total and organic Se in crops across areas with different Se levels varied significantly.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127525"},"PeriodicalIF":3.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between iron status, preeclampsia and gestational hypertension: A bidirectional two-sample Mendelian randomization study","authors":"Pengsheng Li ,&nbsp;Haiyan Wang ,&nbsp;Ting Chen ,&nbsp;Gengdong Chen ,&nbsp;Zixing Zhou ,&nbsp;Shaoxin Ye ,&nbsp;Dongxin Lin ,&nbsp;Dazhi Fan ,&nbsp;Xiaoling Guo ,&nbsp;Zhengping Liu","doi":"10.1016/j.jtemb.2024.127528","DOIUrl":"10.1016/j.jtemb.2024.127528","url":null,"abstract":"<div><h3>Background</h3><p>Several recent observational studies have reported that iron overload during pregnancy is associated with preeclampsia (PE) and gestational hypertension (GH). However, the causal association between iron status, PE, and GH is still not clear.</p></div><div><h3>Methods</h3><p>We performed a two-sample Mendelian randomization (MR) study using the genome-wide association study (GWAS) summary statistics of iron status, included serum iron, ferritin, total iron-binding capacity (TIBC), and transferrin saturation (TSAT) from the largest available GWAS meta-analysis, and the summary statistics of PE and GH were obtained from the FinnGen consortium. Fixed-effect inverse variance weighted (IVW), random-effect IVW, maximum likelihood (ML), MR-Egger regression, weighted median, and MR-PRESSO methods were used.</p></div><div><h3>Results</h3><p>A total of 21, 58, 28, and 22 SNPs were used as IVs for serum iron, ferritin, TIBC, and TSAT, respectively. The F-statistics of IVs ranged from 95.23 to 421.36. The results of the fixed effects IVW method suggested that for per SD unit increase in serum iron, the risk of PE increases by 24 % (OR = 1.24, 95 % CI: 1.03–1.50, P = 0.02). No significant heterogeneity or horizontal pleiotropy was found. The association between ferritin, TIBC, TSAT and PE were statistically insignificant (P&gt;0.05). Furthermore, the results of each MR methods do not support a causal association between iron status and GH, nor a reverse causal association between PE and GH and iron status.</p></div><div><h3>Conclusion</h3><p>This two-sample MR study provides evidence supporting a causal association between serum iron level and PE.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127528"},"PeriodicalIF":3.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal zinc deficiency alters offspring metabolic status in Drosophila melanogaster","authors":"Kamaldeen Olalekan Sanusi ,&nbsp;Kasimu Ghandi Ibrahim ,&nbsp;Murtala Bello Abubakar ,&nbsp;Mustapha Umar Imam","doi":"10.1016/j.jtemb.2024.127519","DOIUrl":"10.1016/j.jtemb.2024.127519","url":null,"abstract":"<div><h3>Background</h3><p>This study delves into the understudied yet potentially crucial role of paternal zinc deficiency in programming offspring metabolic outcomes. By examining paternal zinc deficiency, we aim to shed light on a previously unexplored avenue with the potential to significantly impact future generations. We investigated the intergenerational effects of paternal zinc deficiency on metabolic parameters in <em>Drosophila melanogaster</em>.</p></div><div><h3>Methods</h3><p>Dietary zinc deficiency was induced by supplementing the diet of Drosophila F0 male flies with TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine) from egg stage. The F0 male flies after eclosion were mated with age-matched virgin female flies from the control group, resulting in the F1 offspring generation. The F1 generation were then cultured on a standard diet for subsequent metabolic analyses, including assessments of body weight, locomotion, and levels of glucose, trehalose, glycogen, and triglycerides as well as the expression of related genes.</p></div><div><h3>Results</h3><p>We observed an increase (p&lt;0.05) in body weight in male parent flies and female offspring. Negative geotaxis performance was also impaired in the female offspring. Paternal zinc deficiency exerted distinct effects on carbohydrate and lipid metabolism, as evidenced by a significant (p&lt;0.05) increase in trehalose and triglyceride levels in both parent and offspring. Additionally, zinc deficiency led to alterations in the expression of key metabolic genes, including significant (p&lt;0.05) increase in <em>DILP2</em> mRNA levels, highlighting potential links to insulin signaling. Also, there were reduced mRNA levels of <em>SOD1</em> and <em>CAT</em> in both parental and offspring generations. Parental zinc deficiency also increased the expression of <em>Eiger</em> and <em>UPD2</em> mRNA in the offspring, suggesting potential perturbations in the immune response system.</p></div><div><h3>Conclusion</h3><p>These findings underscore the link between zinc status and various physiological and molecular processes, revealing both immediate and intergenerational impacts on metabolic, antioxidant, and inflammatory pathways and providing valuable insights on the implications of paternal zinc deficiency in <em>Drosophila melanogaster</em>.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127519"},"PeriodicalIF":3.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fluoride toxicity on the male reproductive system: A review","authors":"Bhavna Patial ,&nbsp;Imtiaza Khan ,&nbsp;Ruhi Thakur ,&nbsp;Aditi Fishta","doi":"10.1016/j.jtemb.2024.127522","DOIUrl":"10.1016/j.jtemb.2024.127522","url":null,"abstract":"<div><h3>Background</h3><p>Fluoride toxicity and fluorosis is an emerging global problem. Fluoride has long been added to water for dental caries prevention; however, it has a variety of damaging consequences on human bodies. The aim of this paper is to analyse all the literature available on the effects of fluoride toxicity on male reproductive system.</p></div><div><h3>Methods</h3><p>Research papers were collected using various methods of data collection like Pubmed, Scopus, and Google Scholar from 1980 to 2024, and then reviewed thoroughly.</p></div><div><h3>Results</h3><p>Fluoride is known to cause various histopathological and biochemical alterations in the male reproductive system. It also affects fertility, semen quality, sperm number and quality,the process of spermatogenesis and spermiogenesis. Key changes caused by fluoride in male reproductive system include structural defects in the flagellum, acrosome, and nucleus of spermatids and epididymal spermatozoa. Degenerative changes in Leydig cells result in reduced testosterone production, causing regression of seminiferous tubules and structural damage to the epididymis, ultimately terminating spermatogenesis which leads to infertility. Decrease in levels of testosterone and activities of various antioxidant enzymes resulting in greater oxidative stress was also seen.</p></div><div><h3>Conclusions</h3><p>Fluoride has various detrimental effects on male reproductive system and overall reproductive health. This type of study is important for understanding the effects of fluoride toxicity so that health officials can guide public about safe fluoride exposure limits and the damages it can cause in higher concentrations. Studies using various natural and synthetic ameliorative substances mentioned in the text later can prove to be helpful for development of various therapeutic approaches to mitigate the effects of fluoride toxicity.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127522"},"PeriodicalIF":3.6,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}