Journal of the History of the Neurosciences最新文献

Jean-Martin Charcot believed that "miraculous" cures followed the rules of nature and that the resolution of physical stigmata after pilgrimages to shrines followed the laws of physiology. He acknowledged that some of the patients he had failed to improve at La Salpêtrière had subsequently been cured by the "faith cure" at Lourdes, but he believed their recovery had occurred through "autosuggestion." Although this term is more commonly associated with his collaborator Pierre Janet, it is clearly expressed in Charcot's final pronouncements. Charcot's recognition of the neurological origin of hysteria is central to contemporary ideas about the cause of functional neurological disorders, and even some components of his once derided treatment approach-including mental training, graded exercise, and medical hypnotism-are in vogue.

António Egas Moniz, born in 1874, was a pioneer in neurology, neurosurgery and psychiatry who brought about important changes in the 1920s using groundbreaking brain imaging techniques, such as cerebral angiography. This innovative procedure allowed the visualization of brain structures, leading to many advances in neurology and neurosurgery. Moniz also made noteworthy contributions to psychosurgery, including the development of prefrontal lobotomy. Although initially praised for his inventive techniques, lobotomy sparked ethical debates and public controversies due to its adverse effects and questionable scientific foundation. Moniz's was awarded the Nobel Prize in Physiology or Medicine in 1949 and received various honors in Portugal for his scientific, literary, and artistic achievements. His work continues to influence the field of neuroscience, and angiography remains a crucial imaging method for diagnosing and treating brain disorders. Moniz's complex legacy highlights the intricate balance between medical advances, ethical considerations, and public perceptions in the history of medicine.

The hundredth anniversary of the death of French histologist Louis Ranvier (1835‒1922) is an opportunity to reexamine his elaboration of the first concept of the Schwann cell. A loyal supporter of Theodor Schwann and his discoveries, and an attentive reader of the work of Albert von Kölliker, Ranvier studied the anatomic details of the myelinated nerve fiber with picrocarminate staining. The diffusion of the dye into the nerve fiber at the cut ends and at the sites of the annular constrictions (Ranvier's nodes) set him on the path to defining a new cellular entity surrounding the axon, the "interannular segment," comprising a Schwann nucleus, myelin, and cytoplasm. Ramón y Cajal recognized in 1913 that this concept of the Schwann cell according to Ranvier and his pupil William Vignal had been a brilliant intuition, but it was widely rejected until it was rediscovered using electron microscopy in the 1950s. The article reconstructs the steps of Ranvier and Vignal in building this Schwann cell concept, as well as establishing bridges with the discoveries of the 1950s.

In the neurosciences, concepts play an important role in the conception and direction of research. Among the theoretical notions and direction of research, plasticity stands out because of the multiple ways in which scientists use it to describe and interpret how the nervous system changes and adapts to different requirements. The occurrence of different conceptualizations of plasticity in the scientific literature during the second half of the twentieth century and up to the present was investigated using bibliometric methods. Throughout the period analyzed, synaptic plasticity has remained the dominant conceptualization of plasticity. However, scientists have continued to introduce novel plasticity concepts reflecting the scientific advances they have made in understanding the dynamic nature of the nervous system. The conceptual evolution of plasticity documents that the view of the adult nervous system as immutable has been replaced by an understanding of the nervous system as capable of lifelong change and adaptation.

In November 1881, the eminent physiologist and physician David Ferrier was prosecuted under the Cruelty to Animals Act 1876. The prosecution was raised by the Victoria Street Society, formerly known as the Society for the Protection of Animals Liable to Vivisection, through its activist founder, Frances Power Cobbe. This article examines the legislative context prior to Ferrier's trial, the personalities involved in the prosecution, and its course and outcome. The resultant impact, both personal, on Cobbe and Ferrier, and professional, on experimental neurophysiology, is discussed, in particular the foundation of the Association for the Advancement of Medicine by Research (AAMR) and the provision of legal support for medical practitioners subject to litigation.

In the course of researching and writing the first-ever book length biography of Edward Graeme Robertson's (1903-1975) eventful life and career in Australasian neurology, a rare 1933 cinema film recording of National Hospital staff at Queen Square has recently been rediscovered. Graeme completed his residency in neurology at Queen Square in the early 1930s and maintained close connections with his colleagues in London, thoughtfully recording them at different times using early movie cameras. Two versions of Graeme's 1933 film have been preserved, and there are also other color clips of his colleagues from later in life in the UCL Neurology archives and Robertson family collection. These remarkable films contain images of several historically significant neurologists, including Gordon Morgan Holmes (1876-1965), Samuel Alexander Kinnier Wilson (1878-1937), Derek Denny-Brown (1901-1981), Macdonald Critchley (1900-1997), and several others. We provide a contextual summary of the many clips recorded alongside an in-depth inventory of all the personalities represented in the 1933 film. Selected photographs are used to indicate the contents of these remarkable films.

Thomas Hun (1808-1896)-along with his sons Edward (1842-1880) and Henry (1854-1924)-were prime movers in establishing the clinical practice and academic discipline of neurology in the Hudson River Valley of New York in the ninteenth and early-twentieth centuries. This article outlines the life of the family's semi-aristocratic patriarch, beginning with Thomas's unusual educational background and his six-year post-graduate hiatus in Paris of the 1830s, where he came under the influence of P. C. A. Louis (1787-1872). It lays out his subsequent career as professor of the Institutes of Medicine and ultimately as dean of an American medical school that was not situated in a major metropolis. It also will demonstrate how Thomas Hun's career as a medical practitioner, academician, neurophilosopher, and "proto-neurologist" recapitulates the evolution of clinical and academic neurology in nineteenth-century America.

Ivane Beritashvili has been regarded as an "anti-Pavlovian" for nearly a century. One respect in which Beritashvili is said to be anti-Pavlovian is in granting an explanatory role to subjective mental states in his doctrine of image-driven behavior. In this article, I aim to problematize the anti-Pavlovian assessment and argue that Beritashvili did not deviate from Pavlovian scientific norms, minor points of theoretical and methodological differences between them notwithstanding. Furthermore, several respects in which Beritashvili is claimed to be anti-Pavlovian are ways in which he resembles Pavlov. Turning my attention to Beritashvili's critics in the Soviet Union, those responsible for his censure, I argue that it is the critique of Beritashvili that runs counter to the norms Pavlov embraced. I contest the claim that his alleged deviations from Pavlovian orthodoxy justify classification as anti-Pavlovian in a sense that is either historically accurate or philosophically interesting, and submit that the grounds on which Beritashvili is derided as anti-Pavlovian would also justify labeling Pavlov himself as anti-Pavlovian. Informed by the case of Beritashvili and others who were politically persecuted for their scientific work in the Soviet Union, I conclude with reflections on science, politics, and the intrusion of the latter in the former.

Currently, the idea that the brain is a complex network of interacting brain regions is hardly controversial. The rapid development of this field is often attributed to the emergence of powerful brain-imaging techniques and, around the millennium, the merging of the neuroscience of brain networks with modern mathematical graph theory. However, little is known about the historical roots of this concept. It is interesting to know when the first traces of a concept of brain networks can be found in the work of early neuroscientists, how this concept evolved over time, and what factors may have influenced this evolution. This study aims to set a first step in addressing these questions by a detailed analysis of David Ferrier's classic study, The Functions of the Brain. From this analysis it will become clear that, in addition to a clear notion of localized functions in the brain, Ferrier speculated in several places about the need for several of these brain regions to communicate and interact in order to bring about higher brain functions. He referred to this perspective on the brain as a "complex whole," which could be interpreted as an early precursor of the modern concept of brain networks.

Scholars usually consider the Historia anatomica corporis humani, published in 1600 by André du Laurens, as an obsolete defense of Galenic principles against the novelty of Vesalian material. Although du Laurens's book plagiarized many illustrations from Vesalius's De humani corporis fabrica (1543), critics such as Choulant insisted that the Historia's iconography had "no particular anatomical or artistic value." However, four of the Historia's engravings appear to be original. One of these, the Tabula hæc veram spinalis medullae et nervorum ab ea prodeuntium effigiem exprimit, is now famous for depicting the intradural spinal nerves as a horsetail, leading to the addition of the term cauda equina to the anatomical lexicon. A less flamboyant figure from the same plate shows small blood vessels coursing over the surface of the cervical spinal cord. This drawing may be the first published depiction of anterior spinal arteries and veins.