Journal of Renal Nutrition最新文献

英文中文

Response Letter to Comment on: The Effect of Antihypertensive Therapy on Skeletal Muscle Mass and Bone Mineral Density in Patients With End-Stage Kidney Disease 关于“降压治疗对终末期肾病患者骨骼肌质量和骨密度的影响”评论的回复信。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-07-01 DOI: 10.1053/j.jrn.2025.03.003

Rena Suzukawa, Shintaro Mandai MD, PhD, Hiroko Hashimoto MD, PhD, Satomi Shikuma MD, Mai Kimura MD, Hayato Toma MD, Yuki Sakaguchi MD, Sayuka Shiraishi MD, Noriyuki Toshima MD, Motoki Hoshino MD, Moe Kimura MD, Jun Ota MD, Susumu Horiuchi MD, Susumu Adachi MD, Shinichi Uchida MD

引用次数: 0

Diet Quality Components and Gut Microbiota of Patients on Peritoneal Dialysis 腹膜透析患者饮食质量组成及肠道菌群。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2025.01.001

Christiane Ishikawa Ramos PhD , Laila Santos de Andrade PhD , Renata Rodrigues Teixeira MD , Natália Barros Ferreira Pereira MD , Fabiana da Silva Lima PhD , Christian Hoffmann PhD , Lilian Cuppari PhD

Objectives

To evaluate the associations between the quality of the diet and its components and microbial diversity and composition in peritoneal dialysis (PD) patients.

Design and Methods

This cross-sectional study included PD patients for at least 3 months, aged 18-75 years and clinically stable. The Diet Quality Index (DQI), validated for the Brazilian population, is based on the energy density of 11 components (“sugar and sweets;” “beef, pork, and processed meat;” “refined grains and breads;” “animal fat;” “poultry, fish, and eggs;” “whole cereals, tubers, and roots;” “fruits”; “nonstarch vegetables;” “legumes and nuts;” “milk and dairy products;” and “vegetable oil”). A proportional score—based on the adequacy of the intake to Brazilian dietary guidelines—is calculated, and a final score ranged from 0 (worse) to 100 (better) is obtained. Fecal samples were collected at home, in a sterile material, kept refrigerated, and delivered to the clinic within 12 hours; α-diversity indices (Observed operational taxonomic units, Chao-1, Shannon’s, Gini-Simpson’s, Pielou eveness, and Faith phylogenetics) and microbial profile were determined by 16S ribosomal DNA with polymerase chain reaction-amplification and sequenced on an Illumina MiSeq platform.

Results

Forty-three participants were included (53.5% men, 52.4 ± 14.1 years, body mass index: 25.9 ± 4.1 kg/m², 30.2% had diabetes mellitus). DQI score was 50.5 (41.9-54.9). The lowest energy density was for the components “animal fat” and “whole cereals and breads, tubers, and roots,” and the highest were for “refined grains and bread” and “beef, pork, and processed meat.” Diversity indices and Enterorhabdus genus were directly associated with the energy density of the components “whole cereals and breads, tubers, and roots” and inversely with “refined grains and bread,” after adjustments for age and diabetes.

Conclusions

Even low, the intake of whole cereals, tubers, and roots has the potential to positively influence the microbiota profile in PD patients.

目的：评价腹膜透析（PD）患者饮食质量及其成分与微生物多样性和组成之间的关系。设计和方法：本横断面研究纳入年龄18-75岁且临床稳定的PD患者，时间至少3个月。巴西人的饮食质量指数（DQI）基于11种成分的能量密度(“糖和甜食”；“牛肉、猪肉及加工肉类”；“精制谷物和面包”；“动物脂肪”;“家禽、鱼和蛋”；“全谷类、块茎和块根”；“水果”;“非淀粉蔬菜”;“豆类和坚果”；“牛奶及乳制品”；“植物油”)。根据巴西膳食指南的摄入量是否足够，计算出一个比例分数，并得到一个从0（较差）到100（较好）的最终分数。在家中收集粪便样本，用无菌材料保存，并在12小时内送到诊所。α-多样性指数（OTUs、chao1、Shannon’、gini - simpson’、Pielou均匀度和faith系统发育）和微生物谱采用16S核糖体DNA进行pcr扩增，并在Illumina MiSeq平台上测序。结果：纳入43例受试者（男性53.5%,52.4±14.1岁，BMI:25.9±4.1 kg/m2，糖尿病患者30.2%）。DQI评分为50.5（41.9 ~ 54.9）。能量密度最低的成分是“动物脂肪”和“全谷物和面包、块茎和根茎”，能量密度最高的成分是“精制谷物和面包”和“牛肉、猪肉和加工肉类”。在调整了年龄和糖尿病因素后，肠道菌属的多样性指数与“全谷物和面包、块茎和根”成分的能量密度呈正相关，与“精粮和面包”成分的能量密度呈负相关。结论：即使摄入量很低，全谷物、块茎和根类食物也可能对腹膜透析患者的微生物群有积极的影响。

{"title":"Diet Quality Components and Gut Microbiota of Patients on Peritoneal Dialysis","authors":"Christiane Ishikawa Ramos PhD , Laila Santos de Andrade PhD , Renata Rodrigues Teixeira MD , Natália Barros Ferreira Pereira MD , Fabiana da Silva Lima PhD , Christian Hoffmann PhD , Lilian Cuppari PhD","doi":"10.1053/j.jrn.2025.01.001","DOIUrl":"10.1053/j.jrn.2025.01.001","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the associations between the quality of the diet and its components and microbial diversity and composition in peritoneal dialysis (PD) patients.</div></div><div><h3>Design and Methods</h3><div>This cross-sectional study included PD patients for at least 3 months, aged 18-75 years and clinically stable. The Diet Quality Index (DQI), validated for the Brazilian population, is based on the energy density of 11 components (“sugar and sweets;” “beef, pork, and processed meat;” “refined grains and breads;” “animal fat;” “poultry, fish, and eggs;” “whole cereals, tubers, and roots;” “fruits”; “nonstarch vegetables;” “legumes and nuts;” “milk and dairy products;” and “vegetable oil”). A proportional score—based on the adequacy of the intake to Brazilian dietary guidelines—is calculated, and a final score ranged from 0 (worse) to 100 (better) is obtained. Fecal samples were collected at home, in a sterile material, kept refrigerated, and delivered to the clinic within 12 hours; α-diversity indices (Observed operational taxonomic units, Chao-1, Shannon’s, Gini-Simpson’s, Pielou eveness, and Faith phylogenetics) and microbial profile were determined by 16S ribosomal DNA with polymerase chain reaction-amplification and sequenced on an Illumina MiSeq platform.</div></div><div><h3>Results</h3><div>Forty-three participants were included (53.5% men, 52.4 ± 14.1 years, body mass index: 25.9 ± 4.1 kg/m<sup>2</sup>, 30.2% had diabetes mellitus). DQI score was 50.5 (41.9-54.9). The lowest energy density was for the components “animal fat” and “whole cereals and breads, tubers, and roots,” and the highest were for “refined grains and bread” and “beef, pork, and processed meat.” Diversity indices and <em>Enterorhabdus</em> genus were directly associated with the energy density of the components “whole cereals and breads, tubers, and roots” and inversely with “refined grains and bread,” after adjustments for age and diabetes.</div></div><div><h3>Conclusions</h3><div>Even low, the intake of whole cereals, tubers, and roots has the potential to positively influence the microbiota profile in PD patients.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"35 3","pages":"Pages 454-462"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

May Meeting Announcements 五月会议公告

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2025.03.001

Mary Kay Hensley MS, RDN, FAND, FNKF

引用次数: 0

Navigating Nutrition Therapy for Autosomal Dominant Polycystic Kidney Disease 常染色体显性多囊肾病（ADPKD）的营养治疗导航

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2025.02.007

Diana Bruen MS, RD

引用次数: 0

Magnesium Supplementation Increases Urine Magnesium and Citrate in Stone Formers With Hypomagnesuria 补充镁可增加低镁尿症结石患者尿液中的镁和柠檬酸盐含量。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2024.06.002

Kristina L. Penniston PhD, RDN , Mariana M. Coughlin MS , R. Allan Jhagroo MD

Objectives

To compare the effects of magnesium repletion by a foods-alone approach or by magnesium supplementation on urinary magnesium and citrate excretion in patients with urine magnesium <70 mg/day.

Methods

We reviewed medical records of patients in our stone prevention practice who were advised to start a magnesium supplement (Sup), 250-500 mg/day, or increase dietary magnesium consumption. We included adults with 24-hour urine magnesium (UMg) <70 mg, those who received magnesium recommendations (corroborated by the dietitian’s clinical notes), and those with a follow-up 24-hour urine collection ≤18 months. Urine results were assessed by group.

Results

Groups [No Sup (n = 74) and Sup (n = 56)] were not different for age, gender, stone history, malabsorption, or other clinical indices. All patients raised UMg (53-69 and 47-87 mg/day for No Sup and Sup, respectively); however, the increase was significantly higher in the Sup group. Moreover, while 88% of Sup patients achieved UMg ≥70 mg/day, only 58% in the No Sup group did so. Within-group increases in urine citrate were significant only in the Sup group.

Conclusion

Among patients with low UMg, both higher consumption from foods and magnesium supplementation significantly increased UMg. However, those who supplemented were significantly more likely to reach or exceed UMg 70 mg/day and achieved higher mean UMg. The change in urine citrate was significant only among those in the Sup group.

目的比较单纯食物补镁或镁补充剂对尿镁患者尿镁和枸橼酸盐排泄的影响：我们回顾了结石预防实践中被建议开始服用镁补充剂（Sup）（250-500 毫克/天）或增加膳食镁摄入量的患者的病历。我们纳入了 24 小时尿镁结果的成年人：无Sup组（n=74）和Sup组（n=56）]在年龄、性别、结石病史、吸收不良或其他临床指标方面没有差异。所有患者的 UMg 都有所升高（No Sup 和 Sup 的升高幅度分别为 53 至 69 毫克/天和 47 至 87 毫克/天）；但 Sup 组的升高幅度明显更高。此外，88% 的 Sup 患者 UMg 达到≥70 毫克/天，而 No Sup 组中只有 58% 的患者达到了这一水平。组内尿柠檬酸盐的增加仅在 Sup 组有显著意义：结论：在尿镁低的患者中，从食物中摄取更多的镁和补充镁都能显著提高尿镁。然而，补充镁剂的患者更有可能达到或超过镁70毫克/天，并获得更高的平均镁含量。尿液中柠檬酸盐的变化只有在 Sup 组中才有意义。

{"title":"Magnesium Supplementation Increases Urine Magnesium and Citrate in Stone Formers With Hypomagnesuria","authors":"Kristina L. Penniston PhD, RDN , Mariana M. Coughlin MS , R. Allan Jhagroo MD","doi":"10.1053/j.jrn.2024.06.002","DOIUrl":"10.1053/j.jrn.2024.06.002","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the effects of magnesium repletion by a foods-alone approach or by magnesium supplementation on urinary magnesium and citrate excretion in patients with urine magnesium <70 mg/day.</div></div><div><h3>Methods</h3><div>We reviewed medical records of patients in our stone prevention practice who were advised to start a magnesium supplement (Sup), 250-500 mg/day, or increase dietary magnesium consumption. We included adults with 24-hour urine magnesium (UMg) <70 mg, those who received magnesium recommendations (corroborated by the dietitian’s clinical notes), and those with a follow-up 24-hour urine collection ≤18 months. Urine results were assessed by group.</div></div><div><h3>Results</h3><div>Groups [No Sup (n = 74) and Sup (n = 56)] were not different for age, gender, stone history, malabsorption, or other clinical indices. All patients raised UMg (53-69 and 47-87 mg/day for No Sup and Sup, respectively); however, the increase was significantly higher in the Sup group. Moreover, while 88% of Sup patients achieved UMg ≥70 mg/day, only 58% in the No Sup group did so. Within-group increases in urine citrate were significant only in the Sup group.</div></div><div><h3>Conclusion</h3><div>Among patients with low UMg, both higher consumption from foods and magnesium supplementation significantly increased UMg. However, those who supplemented were significantly more likely to reach or exceed UMg 70 mg/day and achieved higher mean UMg. The change in urine citrate was significant only among those in the Sup group.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"35 3","pages":"Pages 393-400"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of Current Large Language Models and the Retrieval-Augmented Generation Model in Determining Dietary Principles in Chronic Kidney Disease 当前大型语言模型和检索增强生成模型在确定慢性肾脏疾病饮食原则中的准确性。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2025.01.004

Feray Gençer Bingöl PhD , Duygu Ağagündüz PhD , Mustafa Can Bingol PhD

Objective

Large language models (LLMs) have emerged as powerful tools with significant potential for quickly accessing information in the nutrition and health, as in many fields. Retrieval-augmented generation (RAG) has been included among artificial intelligence (AI) powered chatbot structures as a framework developed to increase the accuracy and ability of LLMs. This study aimed to evaluate the accuracy of LLMs (Generative Pre-trained Transformer 4, Gemini, and Llama) and RAG in determining dietary principles in chronic kidney disease.

Design and Methods

The nutrition guideline published by the National Kidney Foundation in 2020 was used as an external information source in developed RAG model. Answers were obtained using 12 medical nutritional therapy prompts for chronic kidney disease by four chatbots. The accuracy of the 48 answers generated by the chatbots was evaluated with a 5-point Likert scale.

Results

The results showed that Gemini and RAG had the highest accuracy scores (median: 4.0), followed by Generative Pre-trained Transformer 4 (median: 2.5) and Llama (median: 1.5), respectively. When the accuracy scores were examined between the two chatbots, a significant difference was detected between all groups except Gemini and RAG.

Conclusion

These chatbots produced both completely correct answers and false information with potentially harmful clinical outcomes. Customization of LLMs in specific areas such as nutrition or the development of a nutrition-specific RAG framework by improving LLM structures with current guidelines and articles may be an important strategy to increase the accuracy of AI powered chatbots.

目的：大型语言模型（LLMs）已经成为一种强大的工具，在营养和健康等许多领域具有快速获取信息的巨大潜力。检索增强生成（RAG）已被纳入人工智能（AI）驱动的聊天机器人结构中，作为提高llm准确性和能力的框架而开发。本研究旨在评估LLMs （GPT4、Gemini和Llama）和RAG在确定慢性肾脏疾病饮食原则方面的准确性。设计与方法：采用国家肾脏基金会2020年发布的营养指南作为外部信息源，建立RAG模型。通过四个聊天机器人使用12个CKD医学营养治疗提示获得答案。由聊天机器人生成的48个答案的准确性用5分李克特量表进行了评估。结果：结果显示，Gemini和RAG的准确率得分最高（中位数：4.0），其次是GPT4（中位数：2.5）和Llama（中位数：1.5）。当检查两个聊天机器人之间的准确性分数时，除了Gemini和RAG之外，所有组之间都存在显着差异。结论：这些聊天机器人既能给出完全正确的答案，也能给出可能有害临床结果的错误信息。定制特定领域的法学硕士（如营养学）或通过使用当前指南和文章改进法学硕士结构来开发营养特定的RAG框架，可能是提高人工智能聊天机器人准确性的重要策略。

{"title":"Accuracy of Current Large Language Models and the Retrieval-Augmented Generation Model in Determining Dietary Principles in Chronic Kidney Disease","authors":"Feray Gençer Bingöl PhD , Duygu Ağagündüz PhD , Mustafa Can Bingol PhD","doi":"10.1053/j.jrn.2025.01.004","DOIUrl":"10.1053/j.jrn.2025.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>Large language models (LLMs) have emerged as powerful tools with significant potential for quickly accessing information in the nutrition and health, as in many fields. Retrieval-augmented generation (RAG) has been included among artificial intelligence (AI) powered chatbot structures as a framework developed to increase the accuracy and ability of LLMs. This study aimed to evaluate the accuracy of LLMs (Generative Pre-trained Transformer 4, Gemini, and Llama) and RAG in determining dietary principles in chronic kidney disease.</div></div><div><h3>Design and Methods</h3><div>The nutrition guideline published by the National Kidney Foundation in 2020 was used as an external information source in developed RAG model. Answers were obtained using 12 medical nutritional therapy prompts for chronic kidney disease by four chatbots. The accuracy of the 48 answers generated by the chatbots was evaluated with a 5-point Likert scale.</div></div><div><h3>Results</h3><div>The results showed that Gemini and RAG had the highest accuracy scores (median: 4.0), followed by Generative Pre-trained Transformer 4 (median: 2.5) and Llama (median: 1.5), respectively. When the accuracy scores were examined between the two chatbots, a significant difference was detected between all groups except Gemini and RAG.</div></div><div><h3>Conclusion</h3><div>These chatbots produced both completely correct answers and false information with potentially harmful clinical outcomes. Customization of LLMs in specific areas such as nutrition or the development of a nutrition-specific RAG framework by improving LLM structures with current guidelines and articles may be an important strategy to increase the accuracy of AI powered chatbots.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"35 3","pages":"Pages 401-409"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Discordance Between Creatinine-Based and Cystatin C-Based Estimated Glomerular Filtration Rate: A Matter of Protein Intake? 基于肌酐和胱抑素c的估测GFR之间的不一致：蛋白质摄入量的问题？

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2025.03.007

Michela Saio MD, Giacomo Garibotto MD, Linda W. Moore PhD, RDN

引用次数: 0

Hypomagnesemia is a Risk Factor for Acute Kidney Injury in Patients Admitted With ST-Segment Elevation Myocardial Infarction: A Retrospective Observational Study 低镁血症是st段抬高型心肌梗死患者急性肾损伤的危险因素：一项回顾性观察研究。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2024.12.006

Youkai Jin , Qingcheng Lin , Dingzhou Wang , Mengge Gong , Weijian Huang , Peiren Shan , Dongjie Liang

Objectives

Acute kidney injury (AKI) is prevalent in patients hospitalized with ST segment elevation myocardial infarction (STEMI) and is correlated with worse cardiovascular outcomes. Hypomagnesemia has been found to be associated with an elevated risk of AKI in various patient populations. Nonetheless, the relationship between hypomagnesemia and AKI incidence in patients with STEMI has not been fully elucidated. The study aims to investigate the association between admission serum magnesium levels and the development of AKI in patients with STEMI.

Design and Methods

A total of 1,219 patients with STEMI were retrospectively included in this study and assigned to the hypomagnesemia and nonhypomagnesemia groups. Hypomagnesemia was defined as a serum magnesium level <0.75 mmol/L. The primary study outcome was AKI Incidence during hospitalization. Univariate and multivariate logistic regression analyses were conducted to assess the association between serum magnesium levels and AKI incidence.

Results

Overall, 163 patients (13.4%) met the hypomagnesemia criteria, and 256 (21.0%) patients developed AKI. The AKI incidence was significantly higher in the hypomagnesemia group compared to the nonhypomagnesemia group (31.9% vs. 19.3%; P < .001). Multivariate logistic analysis, adjusted for demographic characteristics and other confounding variables, revealed that hypomagnesemia is a risk factor for AKI (odds ratio: 2.41, 95% confidence interval: 1.61-3.62; P < .001).

Conclusions

Hypomagnesemia at admission is an independent predictor for AKI occurrence in patients with acute STEMI. Therefore, interventions targeting serum magnesium levels to mitigate AKI risk may warrant clinical consideration.

背景：急性肾损伤（AKI）在st段抬高型心肌梗死（STEMI）住院患者中普遍存在，并与较差的心血管预后相关。在不同的患者群体中，低镁血症已被发现与AKI风险升高有关。尽管如此，STEMI患者低镁血症与AKI发生率之间的关系尚未完全阐明。本研究旨在探讨STEMI患者入院时血清镁水平与AKI发展之间的关系。材料和方法：本研究回顾性纳入1219例STEMI患者，并将其分为低镁血症组和非低镁血症组。低镁血症定义为血清镁水平< 0.75 mmol/L。主要研究结果为住院期间AKI发生率。进行单因素和多因素logistic回归分析以评估血清镁水平与AKI发病率之间的关系。结果：总体而言，163例（13.4%）患者符合低镁血症标准，256例（21.0%）患者发生AKI。低镁组AKI发生率明显高于非低镁组(31.9% vs. 19.3%；结论：入院时低镁血症是急性STEMI患者AKI发生的独立预测因子。因此，针对血清镁水平的干预措施来降低AKI风险可能值得临床考虑。

{"title":"Hypomagnesemia is a Risk Factor for Acute Kidney Injury in Patients Admitted With ST-Segment Elevation Myocardial Infarction: A Retrospective Observational Study","authors":"Youkai Jin , Qingcheng Lin , Dingzhou Wang , Mengge Gong , Weijian Huang , Peiren Shan , Dongjie Liang","doi":"10.1053/j.jrn.2024.12.006","DOIUrl":"10.1053/j.jrn.2024.12.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Acute kidney injury (AKI) is prevalent in patients hospitalized with ST segment elevation myocardial infarction (STEMI) and is correlated with worse cardiovascular outcomes. Hypomagnesemia has been found to be associated with an elevated risk of AKI in various patient populations. Nonetheless, the relationship between hypomagnesemia and AKI incidence in patients with STEMI has not been fully elucidated. The study aims to investigate the association between admission serum magnesium levels and the development of AKI in patients with STEMI.</div></div><div><h3>Design and Methods</h3><div>A total of 1,219 patients with STEMI were retrospectively included in this study and assigned to the hypomagnesemia and nonhypomagnesemia groups. Hypomagnesemia was defined as a serum magnesium level <0.75 mmol/L. The primary study outcome was AKI Incidence during hospitalization. Univariate and multivariate logistic regression analyses were conducted to assess the association between serum magnesium levels and AKI incidence.</div></div><div><h3>Results</h3><div>Overall, 163 patients (13.4%) met the hypomagnesemia criteria, and 256 (21.0%) patients developed AKI. The AKI incidence was significantly higher in the hypomagnesemia group compared to the nonhypomagnesemia group (31.9% vs. 19.3%; <em>P</em> < .001). Multivariate logistic analysis, adjusted for demographic characteristics and other confounding variables, revealed that hypomagnesemia is a risk factor for AKI (odds ratio: 2.41, 95% confidence interval: 1.61-3.62; <em>P</em> < .001).</div></div><div><h3>Conclusions</h3><div>Hypomagnesemia at admission is an independent predictor for AKI occurrence in patients with acute STEMI. Therefore, interventions targeting serum magnesium levels to mitigate AKI risk may warrant clinical consideration.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"35 3","pages":"Pages 387-392"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Handheld Dynamometry Testing During Dialysis: Intrarater and Interrater Reliability Study 透析期间的手持式测力测试：内部和内部可靠性研究。

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2025.01.002

Eva Segura-Ortí PhD, PT , Anna Junqué-Jiménez PhD, RN , Valentin Dubuis PT , Maycon M. Reboredo PhD, PT , Vicente Benavent-Caballer PhD, PT , Noemi Valtueña-Gimeno PhD, PT , Fabricio Sciammarella Barros MSc, PT , Daniela Thomé Silva PT , Francisco J. Martinez-Olmos PhD, PT

Objectives

The aim was to assess the intrarater and interrater reliability of the handheld dynamometry testing of lower limb muscles during hemodialysis.

Methods

This is a cross-sectional study including subjects undertaking hemodialysis for at least 3 months. Handheld dynamometer measurements of hip and ankle muscle strength (N) were registered on 4 different occasions, 2 trials by raters A and 2 by raters B, to evaluate the intrarater and interrater reliability. Bland-Altman plots were constructed to examine the agreement between raters by scoring the difference between raters against the mean of both raters’ scores. The intraclass correlation coefficient was used to assess relative intrarater and interrater reliability. Absolute reliability was assessed with the minimal detectable change.

Results

Fifty-six participants (median age, 67 years) data showed high to very high relative reliability (intraclass correlation coefficients 0.75-0.98). Regarding the intrarater absolute reliability, minimal detectable change score 90% confidence interval values ranged from 27.0 to 41.6.5 N (0.14-0.26 N/kg m²) for hip muscles but increased for ankle muscles. Interrater values were wider. The mean difference between trials ranged narrowly across the two-time points for raters A (1.0-19.3 N) and for raters B (1.3 - 11.4 N). The mean difference between raters ranged from 2.4 to 13.5 N. The Bland-Altman plot revealed a systematic bias for raters A in ankle plantar flexion.

Conclusions

The assessment of the hip flexion and abduction strength during dialysis with a handheld dynamometer is reliable and safe. Normalized data provides more reliable results.

目的目的是评估血液透析期间下肢肌肉手持式测力计测试的内部和相互之间的可靠性：这是一项横断面研究，研究对象包括血液透析至少 3 个月的受试者。手持式测力计对髋部和踝部肌肉力量（N）的测量在4个不同场合进行登记，其中2次由评分者A进行，2次由评分者B进行，以评估评分者内部和评分者之间的可靠性。通过将评分者之间的差异与两位评分者评分的平均值进行比较，绘制布兰德-阿尔特曼图来检验评分者之间的一致性。类内相关系数（ICC）用于评估评分者内部和评分者之间的相对可靠性。绝对信度用最小检测变化（MDC）进行评估：56 名参与者（中位年龄 67 岁）的数据显示出较高至非常高的相对可靠性（ICC 为 0.75 至 0.98）。关于评分者内部的绝对可靠性，髋部肌肉的 MDC90 值在 27.0 至 41.6.5 N（0.14 至 0.26 N/Kg m2）之间，但踝部肌肉的 MDC90 值有所增加。评定者之间的差异值更大。评定者 A 和评定者 B 在两个时间点之间的试验平均差异范围较小（分别为 1.0 - 19.3 N 和 1.3 - 11.4 N）。布兰-阿尔特曼曲线图显示，在踝关节跖屈方面，评分员 A 存在系统性偏差。.结论在透析过程中使用手持式测力计评估髋关节屈曲和外展力量是可靠和安全的。归一化数据可提供更可靠的结果。

{"title":"Handheld Dynamometry Testing During Dialysis: Intrarater and Interrater Reliability Study","authors":"Eva Segura-Ortí PhD, PT , Anna Junqué-Jiménez PhD, RN , Valentin Dubuis PT , Maycon M. Reboredo PhD, PT , Vicente Benavent-Caballer PhD, PT , Noemi Valtueña-Gimeno PhD, PT , Fabricio Sciammarella Barros MSc, PT , Daniela Thomé Silva PT , Francisco J. Martinez-Olmos PhD, PT","doi":"10.1053/j.jrn.2025.01.002","DOIUrl":"10.1053/j.jrn.2025.01.002","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim was to assess the intrarater and interrater reliability of the handheld dynamometry testing of lower limb muscles during hemodialysis.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study including subjects undertaking hemodialysis for at least 3 months. Handheld dynamometer measurements of hip and ankle muscle strength (N) were registered on 4 different occasions, 2 trials by raters A and 2 by raters B, to evaluate the intrarater and interrater reliability. Bland-Altman plots were constructed to examine the agreement between raters by scoring the difference between raters against the mean of both raters’ scores. The intraclass correlation coefficient was used to assess relative intrarater and interrater reliability. Absolute reliability was assessed with the minimal detectable change.</div></div><div><h3>Results</h3><div>Fifty-six participants (median age, 67 years) data showed high to very high relative reliability (intraclass correlation coefficients 0.75-0.98). Regarding the intrarater absolute reliability, minimal detectable change score 90% confidence interval values ranged from 27.0 to 41.6.5 N (0.14-0.26 N/kg m<sup>2</sup>) for hip muscles but increased for ankle muscles. Interrater values were wider. The mean difference between trials ranged narrowly across the two-time points for raters A (1.0-19.3 N) and for raters B (1.3 - 11.4 N). The mean difference between raters ranged from 2.4 to 13.5 N. The Bland-Altman plot revealed a systematic bias for raters A in ankle plantar flexion.</div></div><div><h3>Conclusions</h3><div>The assessment of the hip flexion and abduction strength during dialysis with a handheld dynamometer is reliable and safe. Normalized data provides more reliable results.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"35 3","pages":"Pages 433-442"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Egg White Meal on Anemia in Patients on Hemodialysis Taking Erythropoietin and Iron Infusion 蛋白餐对服用促红细胞生成素和输注铁剂的血液透析患者贫血的影响

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition

Pub Date : 2025-05-01 DOI: 10.1053/j.jrn.2024.06.003

Jalal Azmandian MD , Najmeh Shamspour MD , Ali Azmandian MD , Habibeh Ahmadipour MD , Tahereh Alinaghi Langari MD

Objective

Eggs are a useful and cheap food source. We evaluated the effects of egg white meal on anemia in dialysis patients.

Methods

In an open-label, clinical trial, conducted in dialysis centers, 107 hemodialysis patients aged ≥ 18 years with hemoglobin levels below 12 g/dL and requiring treatment with artificial erythropoietin and iron infusion were included in the study. They were divided into a control and an intervention group. The participants in the intervention group consumed an egg white pack (containing 6 egg whites, 96 calories, 24 g protein) as a substitute for meat products 3 days a week for 8 weeks. Finally, changes in serum albumin, hemoglobin, ferritin and iron/total iron-binding capacity, erythropoietin dose, and iron infusion dose were measured.

Results

A total of 107 dialysis patients were studied (55 patients in egg white and 52 in control groups) with the mean age of 54.31 ± 16.35 years and male majority (57.90%). The mean of hemoglobin concentration had no statistically significant difference at baseline (P = .13) and after 4 weeks (P = .48), while after 8 weeks, the mean hemoglobin concentration in the intervention group was significantly higher than the control group (P = .03). Mean of synthetic erythropoietin dose after 4 and 8 weeks was significantly lower in the intervention group compared to the control group (P = .30, P = .001). Lower Erythropoietin Resistance Index values in intervention group were significantly higher than the control group (P = .02).

Conclusion

We observed that consumption of egg whites led to an increase in mean hemoglobin concentration, serum iron, and albumin levels. These results suggest that egg whites could be a useful dietary intervention for dialysis patients with anemia.

物品：鸡蛋是一种有用且廉价的食物来源。我们评估了蛋白粉对透析患者贫血的影响：在透析中心进行的一项开放标签临床试验中，107 名年龄≥18 岁、血红蛋白水平低于 12 g/dL、需要使用人工促红细胞生成素和输注铁剂治疗的血液透析患者参与了研究。他们被分为对照组和干预组。干预组的参与者每周 3 天食用蛋白包（含 6 个蛋白，96 卡路里，24 克蛋白质），以替代肉制品，持续 8 周。最后，测量了血清白蛋白、血红蛋白、铁蛋白和铁/TIBC、促红细胞生成素剂量和铁输注剂量的变化：共有 107 名透析患者接受了研究（蛋白组 55 人，对照组 52 人），平均年龄（54.31±16.35）岁，男性占多数（57.90%）。血红蛋白浓度的平均值在基线（P=0.13）和四周后无显著统计学差异（P=0.48）。(P=0.48），而八周后，干预组的平均血红蛋白浓度明显高于对照组。(4周和8周后，干预组合成促红细胞生成素的平均剂量明显低于对照组（P=0.03）。(P=0.30，P=0.001）干预组的 ERI 值明显低于对照组。(P=0.02)结论：我们观察到，食用蛋清会导致平均血红蛋白浓度、血清铁和白蛋白水平的增加。这些结果表明，蛋清可作为贫血透析患者的有效饮食干预。

{"title":"The Effect of Egg White Meal on Anemia in Patients on Hemodialysis Taking Erythropoietin and Iron Infusion","authors":"Jalal Azmandian MD , Najmeh Shamspour MD , Ali Azmandian MD , Habibeh Ahmadipour MD , Tahereh Alinaghi Langari MD","doi":"10.1053/j.jrn.2024.06.003","DOIUrl":"10.1053/j.jrn.2024.06.003","url":null,"abstract":"<div><h3>Objective</h3><div>Eggs are a useful and cheap food source. We evaluated the effects of egg white meal on anemia in dialysis patients.</div></div><div><h3>Methods</h3><div>In an open-label, clinical trial, conducted in dialysis centers, 107 hemodialysis patients aged ≥ 18 years with hemoglobin levels below 12 g/dL and requiring treatment with artificial erythropoietin and iron infusion were included in the study. They were divided into a control and an intervention group. The participants in the intervention group consumed an egg white pack (containing 6 egg whites, 96 calories, 24 g protein) as a substitute for meat products 3 days a week for 8 weeks. Finally, changes in serum albumin, hemoglobin, ferritin and iron/total iron-binding capacity, erythropoietin dose, and iron infusion dose were measured.</div></div><div><h3>Results</h3><div>A total of 107 dialysis patients were studied (55 patients in egg white and 52 in control groups) with the mean age of 54.31 ± 16.35 years and male majority (57.90%). The mean of hemoglobin concentration had no statistically significant difference at baseline (<em>P</em> = .13) and after 4 weeks (<em>P</em> = .48), while after 8 weeks, the mean hemoglobin concentration in the intervention group was significantly higher than the control group (<em>P</em> = .03). Mean of synthetic erythropoietin dose after 4 and 8 weeks was significantly lower in the intervention group compared to the control group (<em>P</em> = .30, <em>P</em> = .001). Lower Erythropoietin Resistance Index values in intervention group were significantly higher than the control group (<em>P</em> = .02).</div></div><div><h3>Conclusion</h3><div>We observed that consumption of egg whites led to an increase in mean hemoglobin concentration, serum iron, and albumin levels. These results suggest that egg whites could be a useful dietary intervention for dialysis patients with anemia.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"35 3","pages":"Pages 419-424"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Journal of Renal Nutrition

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀