首页 > 最新文献

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine最新文献

英文 中文
Patients' use of Danish emergency medical services before and during the COVID-19 pandemic: a register-based study 患者在 COVID-19 大流行之前和期间使用丹麦紧急医疗服务的情况:一项基于登记的研究
Pub Date : 2024-09-19 DOI: 10.1186/s13049-024-01267-1
Tim Alex Lindskou, Søren Bie Bogh, Torben Anders Kløjgaard, Marianne Fløjstrup, Fredrik Folke, Ulla Væggemose, Helle Collatz Christensen, Erika Frischknecht Christensen, Mikkel Brabrand, Søren Mikkelsen
During the COVID-19 pandemic, disturbing images of ambulances unable to respond to the demands for prehospital assistance appeared from several parts of the world. In Denmark, however, a notion occurred that the demands for emergency medical assistance declined. The purpose of this study was to compare the patients' use of the Danish Emergency Medical Services (EMS) before and during the COVID-19 pandemic. Furthermore, we investigated the overall mortality of the ambulance population, the main reason for calling the emergency medical dispatch centre, and the diagnosis assigned to the admitted patients. The study was a nationwide registry-based cohort study based on the national prehospital medical records and the Danish National Patient Registry. The primary outcome was the requested number of ambulances. Secondary outcomes included the primary reason for contact with the dispatch centre (reflected by the dispatch criteria), patient mortality, and the diagnoses assigned to the patients transported to the hospital by ambulance during the COVID-19 pandemic in Denmark in March–December 2020. Comparisons were made using a similar period in 2019 before the pandemic. In comparison with the baseline values before the pandemic, the total number of patients treated by the EMS was reduced by 4.5% during the COVID-19 pandemic. The number of patients transported to the hospital during the pandemic was similarly reduced by 3.5%. Compared with baseline values, fewer were patients hospitalised with respiratory diseases during the pandemic (a reduction of 53.3% from April 2019 to April 2020). Compared to the baseline period, there were significant increases in both the 48-h mortality (from 1.4% to 1.5%) and the 30-day mortality (from 4.9% to 5.4%) (p < 0.03 and p < 0.001, respectively), in patients hospitalised during the pandemic. During the first wave of the COVID-19 pandemic, the Danish EMS experienced an overall reduction in the requests for and the use of ambulances and, especially, in the number of patients admitted to hospitals for respiratory diseases. Despite the overall reduction in EMS requests, the mortality of the ambulance population increased, indicating that despite the reduced ambulance use, the prehospital population was more severely ill during the pandemic.
在 COVID-19 大流行期间,世界各地出现了救护车无法满足院前援助需求的令人不安的画面。然而,在丹麦却出现了紧急医疗救助需求下降的现象。本研究旨在比较 COVID-19 大流行之前和期间病人使用丹麦紧急医疗服务(EMS)的情况。此外,我们还调查了救护人群的总体死亡率、呼叫紧急医疗调度中心的主要原因以及入院患者的诊断。该研究是一项基于全国院前医疗记录和丹麦全国患者登记的全国性登记队列研究。主要结果是申请救护车的数量。次要结果包括与调度中心联系的主要原因(由调度标准反映)、患者死亡率以及在2020年3月至12月丹麦COVID-19大流行期间救护车送往医院的患者的诊断结果。在大流行发生前的2019年,我们对类似时期进行了比较。与大流行前的基线值相比,在 COVID-19 大流行期间,急救中心救治的病人总数减少了 4.5%。大流行期间送往医院的患者人数同样减少了 3.5%。与基线值相比,大流行期间因呼吸道疾病住院的患者人数减少(2019 年 4 月至 2020 年 4 月期间减少了 53.3%)。与基线值相比,大流行期间住院患者的 48 天死亡率(从 1.4% 上升至 1.5%)和 30 天死亡率(从 4.9% 上升至 5.4%)均显著上升(分别为 p < 0.03 和 p < 0.001)。在 COVID-19 大流行的第一波期间,丹麦的急救服务请求和使用救护车的次数全面减少,尤其是因呼吸道疾病住院的患者人数减少。尽管急救请求总体上减少了,但救护车的死亡率却上升了,这表明尽管救护车的使用减少了,但在大流行病期间,院前病人的病情却更加严重了。
{"title":"Patients' use of Danish emergency medical services before and during the COVID-19 pandemic: a register-based study","authors":"Tim Alex Lindskou, Søren Bie Bogh, Torben Anders Kløjgaard, Marianne Fløjstrup, Fredrik Folke, Ulla Væggemose, Helle Collatz Christensen, Erika Frischknecht Christensen, Mikkel Brabrand, Søren Mikkelsen","doi":"10.1186/s13049-024-01267-1","DOIUrl":"https://doi.org/10.1186/s13049-024-01267-1","url":null,"abstract":"During the COVID-19 pandemic, disturbing images of ambulances unable to respond to the demands for prehospital assistance appeared from several parts of the world. In Denmark, however, a notion occurred that the demands for emergency medical assistance declined. The purpose of this study was to compare the patients' use of the Danish Emergency Medical Services (EMS) before and during the COVID-19 pandemic. Furthermore, we investigated the overall mortality of the ambulance population, the main reason for calling the emergency medical dispatch centre, and the diagnosis assigned to the admitted patients. The study was a nationwide registry-based cohort study based on the national prehospital medical records and the Danish National Patient Registry. The primary outcome was the requested number of ambulances. Secondary outcomes included the primary reason for contact with the dispatch centre (reflected by the dispatch criteria), patient mortality, and the diagnoses assigned to the patients transported to the hospital by ambulance during the COVID-19 pandemic in Denmark in March–December 2020. Comparisons were made using a similar period in 2019 before the pandemic. In comparison with the baseline values before the pandemic, the total number of patients treated by the EMS was reduced by 4.5% during the COVID-19 pandemic. The number of patients transported to the hospital during the pandemic was similarly reduced by 3.5%. Compared with baseline values, fewer were patients hospitalised with respiratory diseases during the pandemic (a reduction of 53.3% from April 2019 to April 2020). Compared to the baseline period, there were significant increases in both the 48-h mortality (from 1.4% to 1.5%) and the 30-day mortality (from 4.9% to 5.4%) (p < 0.03 and p < 0.001, respectively), in patients hospitalised during the pandemic. During the first wave of the COVID-19 pandemic, the Danish EMS experienced an overall reduction in the requests for and the use of ambulances and, especially, in the number of patients admitted to hospitals for respiratory diseases. Despite the overall reduction in EMS requests, the mortality of the ambulance population increased, indicating that despite the reduced ambulance use, the prehospital population was more severely ill during the pandemic.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for traumatic intracranial hemorrhage in mild traumatic brain injury patients at the emergency department: a systematic review and meta-analysis 急诊科轻度脑外伤患者发生外伤性颅内出血的风险因素:系统回顾和荟萃分析
Pub Date : 2024-09-17 DOI: 10.1186/s13049-024-01262-6
Li Jin Yang, Philipp Lassarén, Filippo Londi, Leonardo Palazzo, Alexander Fletcher-Sandersjöö, Kristian Ängeby, Eric Peter Thelin, Rebecka Rubenson Wahlin
Mild traumatic brain injury (mTBI), i.e. a TBI with an admission Glasgow Coma Scale (GCS) of 13–15, is a common cause of emergency department visits. Only a small fraction of these patients will develop a traumatic intracranial hemorrhage (tICH) with an even smaller subgroup suffering from severe outcomes. Limitations in existing management guidelines lead to overuse of computed tomography (CT) for emergency department (ED) diagnosis of tICH which may result in patient harm and higher healthcare costs. To perform a systematic review and meta-analysis to characterize known and potential novel risk factors that impact the risk of tICH in patients with mTBI to provide a foundation for improving existing ED guidelines. The literature was searched using MEDLINE, EMBASE and Web of Science databases. Reference lists of major literature was cross-checked. The outcome variable was tICH on CT. Odds ratios (OR) were pooled for independent risk factors. After completion of screening, 17 papers were selected for inclusion, with a pooled patient population of 26,040 where 2,054 cases of tICH were verified through CT (7.9%). Signs of a skull base fracture (OR 11.71, 95% CI 5.51–24.86), GCS < 15 (OR 4.69, 95% CI 2.76–7.98), loss of consciousness (OR 2.57, 95% CI 1.83–3.61), post-traumatic amnesia (OR 2.13, 95% CI 1.27–3.57), post-traumatic vomiting (OR 2.04, 95% CI 1.11–3.76), antiplatelet therapy (OR 1.54, 95% CI 1.10–2.15) and male sex (OR 1.28, 95% CI 1.11–1.49) were determined in the data synthesis to be statistically significant predictors of tICH. Our meta-analysis provides additional context to predictors associated with high and low risk for tICH in mTBI. In contrast to signs of a skull base fracture and reduction in GCS, some elements used in ED guidelines such as anticoagulant use, headache and intoxication were not predictive of tICH. Even though there were multiple sources of heterogeneity across studies, these findings suggest that there is potential for improvement over existing guidelines as well as a the need for better prospective trials with consideration for common data elements in this area. PROSPERO registration number CRD42023392495.
轻度创伤性脑损伤(mTBI),即入院时格拉斯哥昏迷量表(GCS)为 13-15 分的创伤性脑损伤,是急诊科就诊的常见原因。这些患者中只有一小部分会发生外伤性颅内出血(tICH),还有一小部分会出现严重后果。现有管理指南的局限性导致在急诊科(ED)诊断外伤性颅内出血时过度使用计算机断层扫描(CT),这可能会对患者造成伤害并增加医疗成本。进行系统回顾和荟萃分析,描述影响 mTBI 患者 tICH 风险的已知和潜在新风险因素,为改进现有急诊科指南奠定基础。使用 MEDLINE、EMBASE 和 Web of Science 数据库检索文献。对主要文献的参考文献列表进行了交叉核对。结果变量为 CT 上的 tICH。对独立风险因素的比值比(OR)进行了汇总。完成筛选后,有 17 篇论文被选中纳入,汇总患者人数为 26,040 人,其中 2,054 例 tICH 经 CT 验证(7.9%)。颅底骨折体征(OR 11.71,95% CI 5.51-24.86)、GCS < 15(OR 4.69,95% CI 2.76-7.98)、意识丧失(OR 2.57,95% CI 1.83-3.61)、创伤后健忘(OR 2.13,95% CI 1.27-3.57)、创伤后颅内出血(OR 2.13,95% CI 1.27-3.57)、创伤后颅外出血(OR 2.13,95% CI 5.51-24.86)、创伤后颅内出血(OR 4.69,95% CI 2.76-7.98)。57)、创伤后呕吐(OR 2.04,95% CI 1.11-3.76)、抗血小板治疗(OR 1.54,95% CI 1.10-2.15)和男性性别(OR 1.28,95% CI 1.11-1.49)在数据综合中被确定为对 tICH 有统计学意义的预测因素。我们的荟萃分析为 mTBI 中与 tICH 高风险和低风险相关的预测因素提供了更多的背景信息。与颅底骨折迹象和 GCS 下降相反,急诊室指南中使用的一些因素(如使用抗凝剂、头痛和中毒)并不能预测 tICH。尽管不同研究之间存在多种异质性,但这些研究结果表明,现有指南仍有改进的余地,同时还需要更好的前瞻性试验,并考虑该领域的常见数据元素。PROSPERO 注册号:CRD42023392495。
{"title":"Risk factors for traumatic intracranial hemorrhage in mild traumatic brain injury patients at the emergency department: a systematic review and meta-analysis","authors":"Li Jin Yang, Philipp Lassarén, Filippo Londi, Leonardo Palazzo, Alexander Fletcher-Sandersjöö, Kristian Ängeby, Eric Peter Thelin, Rebecka Rubenson Wahlin","doi":"10.1186/s13049-024-01262-6","DOIUrl":"https://doi.org/10.1186/s13049-024-01262-6","url":null,"abstract":"Mild traumatic brain injury (mTBI), i.e. a TBI with an admission Glasgow Coma Scale (GCS) of 13–15, is a common cause of emergency department visits. Only a small fraction of these patients will develop a traumatic intracranial hemorrhage (tICH) with an even smaller subgroup suffering from severe outcomes. Limitations in existing management guidelines lead to overuse of computed tomography (CT) for emergency department (ED) diagnosis of tICH which may result in patient harm and higher healthcare costs. To perform a systematic review and meta-analysis to characterize known and potential novel risk factors that impact the risk of tICH in patients with mTBI to provide a foundation for improving existing ED guidelines. The literature was searched using MEDLINE, EMBASE and Web of Science databases. Reference lists of major literature was cross-checked. The outcome variable was tICH on CT. Odds ratios (OR) were pooled for independent risk factors. After completion of screening, 17 papers were selected for inclusion, with a pooled patient population of 26,040 where 2,054 cases of tICH were verified through CT (7.9%). Signs of a skull base fracture (OR 11.71, 95% CI 5.51–24.86), GCS < 15 (OR 4.69, 95% CI 2.76–7.98), loss of consciousness (OR 2.57, 95% CI 1.83–3.61), post-traumatic amnesia (OR 2.13, 95% CI 1.27–3.57), post-traumatic vomiting (OR 2.04, 95% CI 1.11–3.76), antiplatelet therapy (OR 1.54, 95% CI 1.10–2.15) and male sex (OR 1.28, 95% CI 1.11–1.49) were determined in the data synthesis to be statistically significant predictors of tICH. Our meta-analysis provides additional context to predictors associated with high and low risk for tICH in mTBI. In contrast to signs of a skull base fracture and reduction in GCS, some elements used in ED guidelines such as anticoagulant use, headache and intoxication were not predictive of tICH. Even though there were multiple sources of heterogeneity across studies, these findings suggest that there is potential for improvement over existing guidelines as well as a the need for better prospective trials with consideration for common data elements in this area. PROSPERO registration number CRD42023392495.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring ambulance clinicians’ clinical reasoning when training mass casualty incidents using virtual reality: a qualitative study 利用虚拟现实技术探讨临床救护人员在大规模伤亡事件培训中的临床推理:一项定性研究
Pub Date : 2024-09-16 DOI: 10.1186/s13049-024-01255-5
S. Heldring, V. Lindström, M. Jirwe, J. Wihlborg
How ambulance clinicians (ACs) handle a mass casualty incident (MCI) is essential for the suffered, but the training and learning for the ACs are sparse and they don’t have the possibility to learn without realistic simulation training. In addition, it is unclear what type of dilemmas ACs process in their clinical reasoning during an MCI. With virtual reality (VR) simulation, the ACs clinical reasoning can be explored in a systematic way. Therefore, the objective was to explore ambulance clinicians’ clinical reasoning when simulating a mass casualty incident using virtual reality. This study was conducted as an explorative interview study design using chart- stimulated recall technique for data collection. A qualitative content analysis was done, using the clinical reasoning cycle as a deductive matrix. A high-fidelity VR simulation with MCI scenarios was used and participants eligible for inclusion were 11 senior ACs. All phases of the clinical reasoning cycle were found to be reflected upon by the participants during the interviews, however with a varying richness of analytic reflectivity. Non-analytic reasoning predominated when work tasks followed specific clinical guidelines, but analytical reasoning appeared when the guidelines were unclear or non-existent. Using VR simulation led to training and reflection on action in a safe and systematic way and increased self-awareness amongst the ACs regarding their preparedness for MCIs. This study increases knowledge both regarding ACs clinical reasoning in MCIs, and insights regarding the use of VR for simulation training.
救护车临床医生(ACs)如何处理大规模伤亡事件(MCI)对于救护人员来说至关重要,但对救护车临床医生的培训和学习却很少,而且他们没有可能在没有真实模拟训练的情况下进行学习。此外,目前还不清楚 AC 在 MCI 期间的临床推理中会遇到什么类型的困境。通过虚拟现实(VR)模拟,可以系统地探索急救人员的临床推理。因此,本研究旨在探索救护车临床医生在使用虚拟现实技术模拟大规模伤亡事件时的临床推理。本研究采用探索性访谈研究设计,使用图表刺激回忆技术收集数据。采用临床推理周期作为演绎矩阵,进行了定性内容分析。研究使用了高保真 VR 模拟 MCI 情景,有资格参与研究的有 11 名高级助理医师。参与者在访谈中对临床推理周期的所有阶段都进行了反思,但分析反思的丰富程度各不相同。当工作任务遵循具体的临床指南时,非分析性推理占主导地位,但当指南不明确或不存在时,分析性推理就会出现。通过使用 VR 模拟,以安全、系统的方式对行动进行了培训和反思,并提高了急诊科医生对自己是否为 MCI 做好准备的自我意识。这项研究既增加了关于急诊科医生在重症监护中临床推理的知识,也增加了关于使用 VR 进行模拟训练的见解。
{"title":"Exploring ambulance clinicians’ clinical reasoning when training mass casualty incidents using virtual reality: a qualitative study","authors":"S. Heldring, V. Lindström, M. Jirwe, J. Wihlborg","doi":"10.1186/s13049-024-01255-5","DOIUrl":"https://doi.org/10.1186/s13049-024-01255-5","url":null,"abstract":"How ambulance clinicians (ACs) handle a mass casualty incident (MCI) is essential for the suffered, but the training and learning for the ACs are sparse and they don’t have the possibility to learn without realistic simulation training. In addition, it is unclear what type of dilemmas ACs process in their clinical reasoning during an MCI. With virtual reality (VR) simulation, the ACs clinical reasoning can be explored in a systematic way. Therefore, the objective was to explore ambulance clinicians’ clinical reasoning when simulating a mass casualty incident using virtual reality. This study was conducted as an explorative interview study design using chart- stimulated recall technique for data collection. A qualitative content analysis was done, using the clinical reasoning cycle as a deductive matrix. A high-fidelity VR simulation with MCI scenarios was used and participants eligible for inclusion were 11 senior ACs. All phases of the clinical reasoning cycle were found to be reflected upon by the participants during the interviews, however with a varying richness of analytic reflectivity. Non-analytic reasoning predominated when work tasks followed specific clinical guidelines, but analytical reasoning appeared when the guidelines were unclear or non-existent. Using VR simulation led to training and reflection on action in a safe and systematic way and increased self-awareness amongst the ACs regarding their preparedness for MCIs. This study increases knowledge both regarding ACs clinical reasoning in MCIs, and insights regarding the use of VR for simulation training.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into epidemiological trends of severe chest injuries: an analysis of age, period, and cohort from 1990 to 2019 using the Global Burden of Disease study 2019 洞察严重胸部损伤的流行病学趋势:利用 2019 年全球疾病负担研究对 1990 年至 2019 年的年龄、时期和队列进行分析
Pub Date : 2024-09-16 DOI: 10.1186/s13049-024-01258-2
Qingsong Chen, Guangbin Huang, Tao Li, Qi Zhang, Ping He, Jun Yang, Yongming Li, Dingyuan Du
This study assessed the global trends and burden of severe chest injury, including rib fractures, lung contusions, and heart injuries from 1990 to 2019. Herein, we predicted the burden patterns and temporal trends of severe chest injuries to provide epidemiological evidence globally and in China. In our analysis, the age-standardized incidence rate (ASIR), prevalence rate (ASPR), and years lived with disability rate (ASYR) of severe chest injury were analyzed by gender, age, sociodemographic index, and geographical region between 1990 and 2019 using data from the Global Burden of Disease study 2019. Trends were depicted by calculating the estimated annual percentage changes (EAPCs). The impact of age, period, and cohort factors was assessed using an Age-Period-Cohort model. Autoregressive integrated moving average (ARIMA) model was employed to predict severe chest injury trends from 2020 to 2050. In 2019, the global number of severe chest injury cases reached 7.95 million, with the highest incidence rate observed in Central Europe (209.61). Afghanistan had the highest ASIRs at 277.52, while North Korea had the lowest ASIRs at 41.02. From 1990 to 2019, the Syrian Arab Republic saw significant increases in ASIR, ASPR, and ASYR, with EAPCs of 10.4%, 9.31%, and 10.3%, respectively. Burundi experienced a decrease in ASIR with an EAPC of − 6.85% (95% confidence interval [CI] − 11.11, − 2.37), while Liberia’s ASPR and ASYR declined with EAPCs of − 3.22% (95% CI − 4.73, − 1.69) and − 5.67% (95% CI − 8.00, − 3.28), respectively. Falls and road injuries remained the most common causes. The relative risk of severe chest injury by age, period, and cohort demonstrated a complex effect globally and in China. The ARIMA model forecasted a steady increase in global numbers from 2020 to 2050, while in China, it forecasted an increase in incidence, a decrease in ASIR and ASYR, and an increase in ASPR. This study provides a groundbreaking analysis of global severe chest injury, shedding light on its measures and impact. These findings highlight the need for timely, specialized care and addressing regional disparities to mitigate the severe chest injury burden.
本研究评估了 1990 年至 2019 年严重胸部损伤(包括肋骨骨折、肺挫伤和心脏损伤)的全球趋势和负担。在此,我们预测了严重胸部损伤的负担模式和时间趋势,为全球和中国提供流行病学证据。在我们的分析中,利用 2019 年全球疾病负担研究的数据,按性别、年龄、社会人口指数和地理区域分析了 1990 年至 2019 年期间严重胸部损伤的年龄标准化发病率(ASIR)、患病率(ASPR)和残疾生存年数(ASYR)。通过计算估计年度百分比变化(EAPCs)来描述趋势。使用年龄-时期-队列模型评估了年龄、时期和队列因素的影响。自回归综合移动平均(ARIMA)模型用于预测 2020 年至 2050 年的严重胸部损伤趋势。2019 年,全球严重胸部损伤病例数达到 795 万,中欧的发病率最高(209.61)。阿富汗的 ASIR 最高,为 277.52,而朝鲜的 ASIR 最低,为 41.02。从 1990 年到 2019 年,阿拉伯叙利亚共和国的 ASIR、ASPR 和 ASYR 显著增加,EAPC 分别为 10.4%、9.31% 和 10.3%。布隆迪的 ASIR 有所下降,其 EAPC 为 -6.85%(95% 置信区间 [CI] -11.11,-2.37),而利比里亚的 ASPR 和 ASYR 有所下降,其 EAPC 分别为 -3.22%(95% 置信区间 -4.73,-1.69)和 -5.67%(95% 置信区间 -8.00,-3.28)。跌倒和道路伤害仍然是最常见的原因。按年龄、时期和队列划分的严重胸部损伤相对风险显示了全球和中国的复杂效应。根据 ARIMA 模型预测,从 2020 年到 2050 年,全球发病人数将稳步上升,而中国的发病率将上升,ASIR 和 ASYR 将下降,ASPR 将上升。本研究对全球严重胸部损伤进行了突破性分析,阐明了其措施和影响。这些发现强调了及时提供专业护理和解决地区差异以减轻严重胸部损伤负担的必要性。
{"title":"Insights into epidemiological trends of severe chest injuries: an analysis of age, period, and cohort from 1990 to 2019 using the Global Burden of Disease study 2019","authors":"Qingsong Chen, Guangbin Huang, Tao Li, Qi Zhang, Ping He, Jun Yang, Yongming Li, Dingyuan Du","doi":"10.1186/s13049-024-01258-2","DOIUrl":"https://doi.org/10.1186/s13049-024-01258-2","url":null,"abstract":"This study assessed the global trends and burden of severe chest injury, including rib fractures, lung contusions, and heart injuries from 1990 to 2019. Herein, we predicted the burden patterns and temporal trends of severe chest injuries to provide epidemiological evidence globally and in China. In our analysis, the age-standardized incidence rate (ASIR), prevalence rate (ASPR), and years lived with disability rate (ASYR) of severe chest injury were analyzed by gender, age, sociodemographic index, and geographical region between 1990 and 2019 using data from the Global Burden of Disease study 2019. Trends were depicted by calculating the estimated annual percentage changes (EAPCs). The impact of age, period, and cohort factors was assessed using an Age-Period-Cohort model. Autoregressive integrated moving average (ARIMA) model was employed to predict severe chest injury trends from 2020 to 2050. In 2019, the global number of severe chest injury cases reached 7.95 million, with the highest incidence rate observed in Central Europe (209.61). Afghanistan had the highest ASIRs at 277.52, while North Korea had the lowest ASIRs at 41.02. From 1990 to 2019, the Syrian Arab Republic saw significant increases in ASIR, ASPR, and ASYR, with EAPCs of 10.4%, 9.31%, and 10.3%, respectively. Burundi experienced a decrease in ASIR with an EAPC of − 6.85% (95% confidence interval [CI] − 11.11, − 2.37), while Liberia’s ASPR and ASYR declined with EAPCs of − 3.22% (95% CI − 4.73, − 1.69) and − 5.67% (95% CI − 8.00, − 3.28), respectively. Falls and road injuries remained the most common causes. The relative risk of severe chest injury by age, period, and cohort demonstrated a complex effect globally and in China. The ARIMA model forecasted a steady increase in global numbers from 2020 to 2050, while in China, it forecasted an increase in incidence, a decrease in ASIR and ASYR, and an increase in ASPR. This study provides a groundbreaking analysis of global severe chest injury, shedding light on its measures and impact. These findings highlight the need for timely, specialized care and addressing regional disparities to mitigate the severe chest injury burden.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Workplace violence against healthcare workers in the emergency department — a 10-year retrospective single-center cohort study 急诊科医护人员遭受的工作场所暴力--一项为期 10 年的单中心队列回顾性研究
Pub Date : 2024-09-16 DOI: 10.1186/s13049-024-01250-w
Leo Benning, Gisbert W. Teepe, Jan Kleinekort, Jorun Thoma, Michael Clemens Röttger, Andrea Prunotto, Dominik Gottlieb, Stefan Klöppel, Hans-Jörg Busch, Felix P. Hans
Medical staff are regularly confronted with workplace violence (WPV), which poses a threat to the safety of both staff and patients. Structured de-escalation training (DET) for Emergency Department (ED) staff has been shown to positively affect the reporting of WPV incidents and possibly reduce its impact. This study aimed to describe the development of incidence rates, causes, means, targets, locations, responses, and the time of WPV events. Additionally, it explored the effect of the staff trained in DET on the objective and subjective severity of the respective WPV events. In a retrospective, single-center cohort study, we analyzed ten years of WPV events using the data of Staff Observation Aggression Scale-Revised (SOAS-R) score (ranging from 0 to 22) in a tertiary ED from 2014 to 2023. The events were documented by ED staff and stored in the electronic health record (EHR). Between 2014 and 2023, 160 staff members recorded 859 incidents, noting an average perceived severity of 5.78 (SD = 2.65) and SOAS-R score of 11.18 (SD = 4.21). Trends showed a non-significant rise in incident rates per 10,000 patients over time. The WPV events were most frequently reported by nursing staff, and the cause of the aggression was most often not discernible (n = 353, 54.56%). In total, n = 273 (31.78%) of the WPV events were categorized as severe, and the most frequent target of the aggressive behavior was the staff. WPV events occurred most frequently in the traumatology section and the detoxification rooms. While the majority of events could be addressed with verbal interventions, more forceful interventions were performed significantly more often for higher severity WPV events. More WPV events occurred during off-hours and were of a significantly higher objective and subjective severity. Overall, the presence of staff with completed DET led to significantly higher SOAS-R scores and higher perceived severity. The findings underline the relevance of WPV events in the high-risk environment of an ED. The analyzed data suggest that DET significantly fostered the awareness of WPV. While most events can be addressed with verbal interventions, WPV remains a concern that needs to be addressed through organizational measures and further research.
医务人员经常会遇到工作场所暴力 (WPV),这对医务人员和患者的安全都构成了威胁。针对急诊科(ED)工作人员的结构化降级培训(DET)已被证明会对 WPV 事件的报告产生积极影响,并有可能降低其影响。本研究旨在描述 WPV 事件的发生率、原因、手段、目标、地点、反应和时间的发展情况。此外,研究还探讨了接受过 DET 培训的人员对相应 WPV 事件的客观和主观严重性的影响。在一项回顾性、单中心队列研究中,我们使用员工观察侵犯量表-修订版(SOAS-R)的评分数据(0 至 22 分不等)分析了一家三级急诊室 2014 年至 2023 年十年间发生的 WPV 事件。这些事件由急诊室员工记录并存储在电子病历(EHR)中。2014年至2023年期间,160名工作人员记录了859起事件,平均感知严重程度为5.78(标度=2.65),SOAS-R评分为11.18(标度=4.21)。随着时间的推移,每万名患者的事件发生率呈上升趋势,但上升幅度不大。最常报告 WPV 事件的是护理人员,而攻击事件的原因往往无法辨别(n = 353,54.56%)。总共有 n = 273 起(31.78%)WPV 事件被归类为严重事件,而最常见的攻击行为目标是工作人员。WPV 事件最常发生在创伤科和戒毒室。虽然大多数事件都可以通过口头干预来解决,但在严重程度较高的 WPV 事件中,更多的情况下会采取更为强硬的干预措施。更多的 WPV 事件发生在非工作时间,其客观和主观严重程度也明显更高。总体而言,有完成 DET 的工作人员在场,SOAS-R 得分会明显提高,感知到的严重程度也会更高。研究结果强调了 WPV 事件与急诊室高风险环境的相关性。分析数据表明,DET 极大地促进了对 WPV 的认识。虽然大多数事件可以通过口头干预来解决,但 WPV 仍是一个需要通过组织措施和进一步研究来解决的问题。
{"title":"Workplace violence against healthcare workers in the emergency department — a 10-year retrospective single-center cohort study","authors":"Leo Benning, Gisbert W. Teepe, Jan Kleinekort, Jorun Thoma, Michael Clemens Röttger, Andrea Prunotto, Dominik Gottlieb, Stefan Klöppel, Hans-Jörg Busch, Felix P. Hans","doi":"10.1186/s13049-024-01250-w","DOIUrl":"https://doi.org/10.1186/s13049-024-01250-w","url":null,"abstract":"Medical staff are regularly confronted with workplace violence (WPV), which poses a threat to the safety of both staff and patients. Structured de-escalation training (DET) for Emergency Department (ED) staff has been shown to positively affect the reporting of WPV incidents and possibly reduce its impact. This study aimed to describe the development of incidence rates, causes, means, targets, locations, responses, and the time of WPV events. Additionally, it explored the effect of the staff trained in DET on the objective and subjective severity of the respective WPV events. In a retrospective, single-center cohort study, we analyzed ten years of WPV events using the data of Staff Observation Aggression Scale-Revised (SOAS-R) score (ranging from 0 to 22) in a tertiary ED from 2014 to 2023. The events were documented by ED staff and stored in the electronic health record (EHR). Between 2014 and 2023, 160 staff members recorded 859 incidents, noting an average perceived severity of 5.78 (SD = 2.65) and SOAS-R score of 11.18 (SD = 4.21). Trends showed a non-significant rise in incident rates per 10,000 patients over time. The WPV events were most frequently reported by nursing staff, and the cause of the aggression was most often not discernible (n = 353, 54.56%). In total, n = 273 (31.78%) of the WPV events were categorized as severe, and the most frequent target of the aggressive behavior was the staff. WPV events occurred most frequently in the traumatology section and the detoxification rooms. While the majority of events could be addressed with verbal interventions, more forceful interventions were performed significantly more often for higher severity WPV events. More WPV events occurred during off-hours and were of a significantly higher objective and subjective severity. Overall, the presence of staff with completed DET led to significantly higher SOAS-R scores and higher perceived severity. The findings underline the relevance of WPV events in the high-risk environment of an ED. The analyzed data suggest that DET significantly fostered the awareness of WPV. While most events can be addressed with verbal interventions, WPV remains a concern that needs to be addressed through organizational measures and further research.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142251040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival of the fastest? A descriptive analysis of severely injured trauma patients primarily admitted or secondarily transferred to major trauma centers in a Danish inclusive trauma system 最快者生存?对丹麦包容性创伤系统中主要送往或其次转往主要创伤中心的严重创伤患者的描述性分析
Pub Date : 2024-09-14 DOI: 10.1186/s13049-024-01265-3
Thea Palsgaard Møller, Josefine Tangen Jensen, Roar Borregaard Medici, Søren Steemann Rudolph, Lars Bredevang Andersen, Jakob Roed, Stig Nikolaj Fasmer Blomberg, Helle Collatz Christensen, Mark Edwards
Trauma systems are crucial for enhancing survival and quality of life for trauma patients. Understanding trauma triage and patient outcomes is essential for optimizing resource allocation and trauma care. The aim was to explore prehospital trauma triage in Region Zealand, Denmark. Specifically, characteristics for patients who were either primarily admitted or secondarily transferred to major trauma centers were described. A retrospective descriptive study of severely injured trauma patients was conducted from January 2017 to December 2021. The study comprised 744 patients including 55.6% primary and 44.4% secondary patients. Overall, men accounted for 70.2% of patients, and 66.1% were aged 18–65 years. The secondary patients included more women—34.2% versus 26.3% and a higher proportion of Injury Severity Score of ≥ 15—59.6% versus 47.8%, compared to primary patients. 30-day survival was higher for secondary patients—92.7% versus 87%. Medical dispatchers assessed urgency as Emergency level A for 98.1% of primary patients and 86.3% for secondary patients. Physician-staffed prehospital units attended primary patients first more frequently—17.1% versus 3.5%. Response times were similar, but time at scene was longer for primary patients whereas time from injury to arrival at a major trauma center was longer for secondary patients. Secondary trauma patients had higher Injury Severity Scores and better survival rates. They were considered less urgent by medical dispatchers and less frequently assessed by physician-staffed units. Prospective quality data are needed for further investigation of optimal triage and continuous quality improvement in trauma care.
创伤系统对提高创伤患者的生存率和生活质量至关重要。了解创伤分流和患者预后对于优化资源分配和创伤救治至关重要。该研究旨在探讨丹麦新西兰地区的院前创伤分流。具体来说,该研究描述了主要送往或次要转往主要创伤中心的患者的特征。2017 年 1 月至 2021 年 12 月期间,对严重受伤的创伤患者进行了一项回顾性描述研究。研究对象包括744名患者,其中55.6%为主要患者,44.4%为次要患者。总体而言,男性患者占 70.2%,66.1% 的患者年龄在 18-65 岁之间。与原发性患者相比,继发性患者中有更多女性--34.2%对26.3%,受伤严重程度评分≥15-59.6%对47.8%的比例更高。二级患者的 30 天存活率更高,为 92.7% 对 87%。医疗调度员将98.1%的一级患者和86.3%的二级患者的紧急程度评估为A级。由医生值班的院前医疗单位更频繁地首先救治初诊患者--17.1% 对 3.5%。响应时间相似,但初级患者在现场的时间更长,而二级患者从受伤到到达主要创伤中心的时间更长。二级创伤患者的受伤严重程度评分更高,存活率更高。医疗调度员认为他们的情况不那么紧急,由医生组成的小组也较少对他们进行评估。需要前瞻性的质量数据来进一步调查最佳分流和持续改进创伤护理质量。
{"title":"Survival of the fastest? A descriptive analysis of severely injured trauma patients primarily admitted or secondarily transferred to major trauma centers in a Danish inclusive trauma system","authors":"Thea Palsgaard Møller, Josefine Tangen Jensen, Roar Borregaard Medici, Søren Steemann Rudolph, Lars Bredevang Andersen, Jakob Roed, Stig Nikolaj Fasmer Blomberg, Helle Collatz Christensen, Mark Edwards","doi":"10.1186/s13049-024-01265-3","DOIUrl":"https://doi.org/10.1186/s13049-024-01265-3","url":null,"abstract":"Trauma systems are crucial for enhancing survival and quality of life for trauma patients. Understanding trauma triage and patient outcomes is essential for optimizing resource allocation and trauma care. The aim was to explore prehospital trauma triage in Region Zealand, Denmark. Specifically, characteristics for patients who were either primarily admitted or secondarily transferred to major trauma centers were described. A retrospective descriptive study of severely injured trauma patients was conducted from January 2017 to December 2021. The study comprised 744 patients including 55.6% primary and 44.4% secondary patients. Overall, men accounted for 70.2% of patients, and 66.1% were aged 18–65 years. The secondary patients included more women—34.2% versus 26.3% and a higher proportion of Injury Severity Score of ≥ 15—59.6% versus 47.8%, compared to primary patients. 30-day survival was higher for secondary patients—92.7% versus 87%. Medical dispatchers assessed urgency as Emergency level A for 98.1% of primary patients and 86.3% for secondary patients. Physician-staffed prehospital units attended primary patients first more frequently—17.1% versus 3.5%. Response times were similar, but time at scene was longer for primary patients whereas time from injury to arrival at a major trauma center was longer for secondary patients. Secondary trauma patients had higher Injury Severity Scores and better survival rates. They were considered less urgent by medical dispatchers and less frequently assessed by physician-staffed units. Prospective quality data are needed for further investigation of optimal triage and continuous quality improvement in trauma care.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142251041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicians’ experience of barriers and facilitators to care delivery of an extracorporeal cardiopulmonary resuscitation service for out-of-hospital cardiac arrest: a qualitative survey 临床医生对针对院外心脏骤停提供体外心肺复苏服务的障碍和促进因素的经验:定性调查
Pub Date : 2024-09-13 DOI: 10.1186/s13049-024-01261-7
Jasper Eddison, Oscar Millerchip, Alex Rosenberg, Asher Lewinsohn, James Raitt
Out-of-hospital cardiac arrest (OHCA) survival in the UK remains overall poor with fewer than 10% of patients surviving to hospital discharge. Extracorporeal cardiopulmonary resuscitation (ECPR) is a developing therapy option that can improve survival in select patients if treatment begins within an hour. Clinicians' perspectives are a pivotal consideration to the development of effective systems for OHCA ECPR, but they have been infrequently explored. This study investigates clinicians' views on the barriers and facilitators to establishing effective systems to facilitate transport of OHCA patients for in-hospital ECPR. In January 2023, Thames Valley Air Ambulance (TVAA) and Harefield Hospital developed an ECPR partnership pathway for conveyance of OHCA patients for in-hospital ECPR. The authors of this study conducted a survey of clinicians across both services looking to identify clear barriers and positive contributors to the effective implementation of the programme. The survey included questions about technical and non-technical barriers and facilitators, with free-text responses analysed thematically. Responses were received from 14 pre-hospital TVAA critical care and 9 in-hospital clinicians’ representative of various roles and experiences. Data analysis revealed 10 key themes and 19 subthemes. The interconnected themes, identified by pre-hospital TVAA critical care clinicians as important barriers or facilitators in this ECPR system included educational programmes; collectiveness in effort and culture; teamwork; inter-service communication; concurrent activity; and clarity of procedures. Themes from in-hospital clinicians’ responses were distilled into key considerations focusing on learning and marginal gains, standardising and simplifying protocols, training and simulation; and nurturing effective teams. This study identified several clear themes and subthemes from clinical experience that should be considered when developing and modelling an ECPR system for OHCA. These insights may inform future development of ECPR programmes for OHCA in other centres. Key recommendations identified include prioritising education and training (including regular simulations), standardising a ‘pitstop style’ handover process, establishing clear roles during the cannulation process and developing standardised protocols and selection criteria. This study also provides insight into the feasibility of using pre-hospital critical care teams for intra-arrest patient retrieval in the pre-hospital arena.
在英国,院外心脏骤停(OHCA)患者的存活率仍然很低,只有不到 10% 的患者能够存活到出院。体外心肺复苏(ECPR)是一种发展中的治疗方法,如果能在一小时内开始治疗,可以提高部分患者的存活率。临床医生的观点是开发有效的 OHCA ECPR 系统的关键考虑因素,但他们的观点却很少被探讨。本研究调查了临床医生对建立有效系统的障碍和促进因素的看法,以促进 OHCA 患者的院内 ECPR 转运。2023 年 1 月,泰晤士河谷空中救护中心(TVAA)和 Harefield 医院制定了 ECPR 合作路径,用于运送 OHCA 患者进行院内 ECPR。本研究的作者对两家医院的临床医生进行了调查,希望找出有效实施该计划的明显障碍和积极因素。调查包括有关技术和非技术障碍及促进因素的问题,并对自由文本回复进行了专题分析。14 名院前 TVAA 重症监护医生和 9 名院内临床医生代表不同的角色和经验进行了回复。数据分析揭示了 10 个关键主题和 19 个次主题。院前 TVAA 重症监护临床医生认为,相互关联的主题包括教育计划、集体努力和文化、团队合作、服务间沟通、同期活动和程序清晰度,这些主题是 ECPR 系统的重要障碍或促进因素。从院内临床医生的回答中提炼出的主题被归纳为主要考虑因素,重点是学习和边际收益、标准化和简化协议、培训和模拟;以及培养有效的团队。这项研究从临床经验中发现了几个明确的主题和次主题,在开发和模拟用于 OHCA 的 ECPR 系统时应加以考虑。这些见解可为其他中心今后开发针对 OHCA 的 ECPR 计划提供参考。确定的主要建议包括优先考虑教育和培训(包括定期模拟)、规范 "中转站式 "交接流程、在插管过程中确立明确的角色以及制定标准化协议和选择标准。这项研究还深入探讨了在院前急救领域使用院前重症监护团队进行急救病人抢救的可行性。
{"title":"Clinicians’ experience of barriers and facilitators to care delivery of an extracorporeal cardiopulmonary resuscitation service for out-of-hospital cardiac arrest: a qualitative survey","authors":"Jasper Eddison, Oscar Millerchip, Alex Rosenberg, Asher Lewinsohn, James Raitt","doi":"10.1186/s13049-024-01261-7","DOIUrl":"https://doi.org/10.1186/s13049-024-01261-7","url":null,"abstract":"Out-of-hospital cardiac arrest (OHCA) survival in the UK remains overall poor with fewer than 10% of patients surviving to hospital discharge. Extracorporeal cardiopulmonary resuscitation (ECPR) is a developing therapy option that can improve survival in select patients if treatment begins within an hour. Clinicians' perspectives are a pivotal consideration to the development of effective systems for OHCA ECPR, but they have been infrequently explored. This study investigates clinicians' views on the barriers and facilitators to establishing effective systems to facilitate transport of OHCA patients for in-hospital ECPR. In January 2023, Thames Valley Air Ambulance (TVAA) and Harefield Hospital developed an ECPR partnership pathway for conveyance of OHCA patients for in-hospital ECPR. The authors of this study conducted a survey of clinicians across both services looking to identify clear barriers and positive contributors to the effective implementation of the programme. The survey included questions about technical and non-technical barriers and facilitators, with free-text responses analysed thematically. Responses were received from 14 pre-hospital TVAA critical care and 9 in-hospital clinicians’ representative of various roles and experiences. Data analysis revealed 10 key themes and 19 subthemes. The interconnected themes, identified by pre-hospital TVAA critical care clinicians as important barriers or facilitators in this ECPR system included educational programmes; collectiveness in effort and culture; teamwork; inter-service communication; concurrent activity; and clarity of procedures. Themes from in-hospital clinicians’ responses were distilled into key considerations focusing on learning and marginal gains, standardising and simplifying protocols, training and simulation; and nurturing effective teams. This study identified several clear themes and subthemes from clinical experience that should be considered when developing and modelling an ECPR system for OHCA. These insights may inform future development of ECPR programmes for OHCA in other centres. Key recommendations identified include prioritising education and training (including regular simulations), standardising a ‘pitstop style’ handover process, establishing clear roles during the cannulation process and developing standardised protocols and selection criteria. This study also provides insight into the feasibility of using pre-hospital critical care teams for intra-arrest patient retrieval in the pre-hospital arena.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142204660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thromboelastography as an early prediction method for hypofibrinogenemia in emergency department patients with primary postpartum hemorrhage 血栓弹性成像是产后原发性出血急诊患者低纤维蛋白原血症的早期预测方法
Pub Date : 2024-09-13 DOI: 10.1186/s13049-024-01263-5
Sang-Min Kim, Chang Hwan Sohn, Hyojeong Kwon, Seung Mok Ryoo, Shin Ahn, Dong Woo Seo, Won Young Kim
Timely and accurate assessment of coagulopathy is crucial for the management of primary postpartum hemorrhage (PPH). Thromboelastography (TEG) provides a comprehensive assessment of coagulation status and is useful for guiding the treatment of hemorrhagic events in various diseases. This study aimed to evaluate the role of TEG in predicting hypofibrinogenemia in emergency department (ED) patients with primary PPH. We conducted a retrospective observational study in the ED of a university-affiliated tertiary hospital between November 2015 and August 2023. TEG was performed upon admission. The cutoff value for hypofibrinogenemia was 200 mg/dL. The primary outcome was the presence of hypofibrinogenemia. Among the 174 patients, 73 (42.0%) had hypofibrinogenemia. The need for massive transfusion was higher in the hypofibrinogenemia group (37.0% vs. 5.0%, p < 0.001). Among the TEG parameters, all values were significantly different between the groups, except for lysis after 30 min, suggesting a tendency toward hypocoagulability. Multivariable analysis revealed that the alpha angle (odds ratio (OR) 0.924, 95% confidence interval (CI) 0.876–0.978) and maximum amplitude (MA) (OR 0.867, 95% CI 0.801–0.938) were independently associated with hypofibrinogenemia. The optimal cutoff values for the alpha angle and maximum amplitude (MA) for hypofibrinogenemia were 63.8 degrees and 56.1 mm, respectively. Point-of-care TEG could be a valuable tool for the early identification of hypofibrinogenemia in ED patients with primary PPH.
及时、准确地评估凝血功能障碍对于治疗原发性产后出血(PPH)至关重要。血栓弹性成像(TEG)可对凝血状态进行全面评估,有助于指导治疗各种疾病的出血事件。本研究旨在评估 TEG 在预测急诊科(ED)原发性 PPH 患者低纤维蛋白原血症中的作用。我们于 2015 年 11 月至 2023 年 8 月在一所大学附属三级医院的急诊科进行了一项回顾性观察研究。入院时进行 TEG 检查。低纤维蛋白原血症的临界值为 200 mg/dL。主要结果是是否存在低纤维蛋白原血症。在 174 名患者中,73 人(42.0%)患有低纤维蛋白原血症。低纤维蛋白原血症组需要大量输血的比例更高(37.0% 对 5.0%,P < 0.001)。在 TEG 参数中,除 30 分钟后的溶解度外,各组间的所有数值均有显著差异,这表明低凝倾向。多变量分析显示,α角(几率比(OR)0.924,95% 置信区间(CI)0.876-0.978)和最大振幅(MA)(OR 0.867,95% CI 0.801-0.938)与低纤维蛋白原血症独立相关。低纤维蛋白原血症的α角和最大振幅(MA)的最佳临界值分别为 63.8 度和 56.1 毫米。护理点 TEG 是早期识别原发性 PPH 急诊患者低纤维蛋白原血症的重要工具。
{"title":"Thromboelastography as an early prediction method for hypofibrinogenemia in emergency department patients with primary postpartum hemorrhage","authors":"Sang-Min Kim, Chang Hwan Sohn, Hyojeong Kwon, Seung Mok Ryoo, Shin Ahn, Dong Woo Seo, Won Young Kim","doi":"10.1186/s13049-024-01263-5","DOIUrl":"https://doi.org/10.1186/s13049-024-01263-5","url":null,"abstract":"Timely and accurate assessment of coagulopathy is crucial for the management of primary postpartum hemorrhage (PPH). Thromboelastography (TEG) provides a comprehensive assessment of coagulation status and is useful for guiding the treatment of hemorrhagic events in various diseases. This study aimed to evaluate the role of TEG in predicting hypofibrinogenemia in emergency department (ED) patients with primary PPH. We conducted a retrospective observational study in the ED of a university-affiliated tertiary hospital between November 2015 and August 2023. TEG was performed upon admission. The cutoff value for hypofibrinogenemia was 200 mg/dL. The primary outcome was the presence of hypofibrinogenemia. Among the 174 patients, 73 (42.0%) had hypofibrinogenemia. The need for massive transfusion was higher in the hypofibrinogenemia group (37.0% vs. 5.0%, p < 0.001). Among the TEG parameters, all values were significantly different between the groups, except for lysis after 30 min, suggesting a tendency toward hypocoagulability. Multivariable analysis revealed that the alpha angle (odds ratio (OR) 0.924, 95% confidence interval (CI) 0.876–0.978) and maximum amplitude (MA) (OR 0.867, 95% CI 0.801–0.938) were independently associated with hypofibrinogenemia. The optimal cutoff values for the alpha angle and maximum amplitude (MA) for hypofibrinogenemia were 63.8 degrees and 56.1 mm, respectively. Point-of-care TEG could be a valuable tool for the early identification of hypofibrinogenemia in ED patients with primary PPH.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142204681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intensive care unit cardiac arrest among very elderly critically ill patients – is cardiopulmonary resuscitation justified? 重症监护室中高龄危重病人心脏骤停--心肺复苏是否合理?
Pub Date : 2024-09-11 DOI: 10.1186/s13049-024-01259-1
Markus Haar, Jakob Müller, Daniela Hartwig, Julia von Bargen, Rikus Daniels, Pauline Theile, Stefan Kluge, Kevin Roedl
The proportion of very elderly patients in the intensive care unit (ICU) is expected to rise. Furthermore, patients are likely more prone to suffer a cardiac arrest (CA) event within the ICU. The occurrence of intensive care unit cardiac arrest (ICU-CA) is associated with high mortality. To date, the incidence of ICU-CA and its clinical impact on outcome in the very old (≥ 90 years) patients treated is unknown. Retrospective analysis of all consecutive critically ill patients ≥ 90 years admitted to the ICU of a tertiary care university hospital in Hamburg (Germany). All patients suffering ICU-CA were included and CA characteristics and functional outcome was assessed. Clinical course and outcome were assessed and compared between the subgroups of patients with and without ICU-CA. 1,108 critically ill patients aged ≥ 90 years were admitted during the study period. The median age was 92.3 (91.0–94.2) years and 67% (n = 747) were female. 2% (n = 25) of this cohort suffered ICU-CA after a median duration 0.5 (0.2–3.2) days of ICU admission. The presumed cause of ICU-CA was cardiac in 64% (n = 16). The median resuscitation time was 10 (2–15) minutes and the initial rhythm was shockable in 20% (n = 5). Return of spontaneous circulation (ROSC) could be achieved in 68% (n = 17). The cause of ICU admission was primarily medical in the total cohort (ICU-CA: 48% vs. No ICU-CA: 34%, p = 0.13), surgical - planned (ICU-CA: 32% vs. No ICU-CA: 37%, p = 0.61) and surgical - unplanned/emergency (ICU-CA: 43% vs. No ICU-CA: 28%, p = 0.34). The median Charlson Comorbidity Index (CCI) was 2 (1–3) points for patients with ICU-CA and 1 (0–2) for patients without ICU-CA (p = 0.54). Patients with ICU-CA had a higher disease severity according to SAPS II (ICU-CA: 54 vs. No ICU-CA: 36 points, p < 0.001). Patients with ICU-CA had a higher rate of mechanically ventilation (ICU-CA: 64% vs. No ICU-CA: 34%, p < 0.01) and required vasopressor therapy more often (ICU-CA: 88% vs. No ICU-CA: 41%, p < 0.001). The ICU and in-hospital mortality was 88% (n = 22) and 100% (n = 25) in patients with ICU-CA compared to 17% (n = 179) and 28% (n = 306) in patients without ICU-CA. The mortality rate for patients with ICU-CA was observed to be 88% (n = 22) in the ICU and 100% (n = 25) in-hospital. In contrast, patients without ICU-CA had an in-ICU mortality rate of 17% (n = 179) and an in-hospital mortality rate of 28% (n = 306) (both p < 0.001). The occurrence of ICU-CA in very elderly patients is rare but associated with high mortality. Providing CPR in this cohort did not lead to long-term survival at our centre. Very elderly patients admitted to the ICU likely benefit from supportive care only and should probably not be resuscitated due to poor chance of survival and ethical considerations. Providing personalized assurances that care will remain appropriate and in accordance with the patient’s and family’s wishes can optimise compassionate care while avoiding futile life-sustaining interven
重症监护室(ICU)中高龄患者的比例预计将上升。此外,患者很可能更容易在重症监护病房内发生心脏骤停(CA)事件。重症监护病房心脏骤停(ICU-CA)的发生与高死亡率有关。迄今为止,在接受治疗的高龄(≥ 90 岁)患者中,ICU-CA 的发生率及其对预后的临床影响尚不清楚。对汉堡(德国)一家三级甲等大学医院重症监护室连续收治的所有年龄≥90岁的重症患者进行了回顾性分析。所有患有重症监护病房急性心肌梗死的患者均被纳入其中,并对急性心肌梗死的特征和功能预后进行了评估。对临床病程和预后进行了评估,并对患有和未患有 ICUCA 的亚组患者进行了比较。研究期间共收治了 1108 名年龄≥ 90 岁的重症患者。中位年龄为 92.3(91.0-94.2)岁,67%(n = 747)为女性。其中 2%(n = 25)的患者在入住 ICU 的中位时间为 0.5(0.2-3.2)天后发生了 ICU-CA。64%(16 人)的 ICU-CA 推测病因是心脏疾病。复苏时间中位数为 10(2-15)分钟,20% 的患者(5 人)的初始心律是可电击的。68%的患者(17 例)可恢复自主循环(ROSC)。在所有队列中,入住 ICU 的原因主要是内科(ICU-CA:48% vs. 无 ICU-CA:34%,p = 0.13)、外科 - 计划内(ICU-CA:32% vs. 无 ICU-CA:37%,p = 0.61)和外科 - 非计划内/急诊(ICU-CA:43% vs. 无 ICU-CA:28%,p = 0.34)。ICU-CA 患者的夏尔森合并症指数(CCI)中位数为 2(1-3)分,无 ICU-CA 患者为 1(0-2)分(P = 0.54)。根据 SAPS II,ICU-CA 患者的疾病严重程度更高(ICU-CA:54 分;无 ICU-CA:36 分,p < 0.001)。ICU-CA 患者的机械通气率更高(ICU-CA:64% 对非 ICU-CA:34%,p < 0.01),需要血管加压疗法的次数更多(ICU-CA:88% 对非 ICU-CA:41%,p < 0.001)。ICU-CA 患者的 ICU 和院内死亡率分别为 88%(22 人)和 100%(25 人),而无 ICU-CA 患者的 ICU 和院内死亡率分别为 17%(179 人)和 28%(306 人)。据观察,ICU-CA 患者在重症监护室的死亡率为 88%(22 人),在院内的死亡率为 100%(25 人)。相比之下,无 ICU-CA 患者的重症监护室内死亡率为 17%(n = 179),院内死亡率为 28%(n = 306)(均 p <0.001)。高龄患者发生重症监护室心肺复苏术的情况很少见,但死亡率却很高。在我们的中心,为该组患者提供心肺复苏并不能提高他们的长期存活率。入住重症监护室的高龄患者可能只能从支持性护理中获益,由于存活几率较低和伦理方面的考虑,可能不应实施复苏。根据患者和家属的意愿提供个性化的护理保证,可以在避免无用的维持生命干预措施的同时,优化体恤护理。
{"title":"Intensive care unit cardiac arrest among very elderly critically ill patients – is cardiopulmonary resuscitation justified?","authors":"Markus Haar, Jakob Müller, Daniela Hartwig, Julia von Bargen, Rikus Daniels, Pauline Theile, Stefan Kluge, Kevin Roedl","doi":"10.1186/s13049-024-01259-1","DOIUrl":"https://doi.org/10.1186/s13049-024-01259-1","url":null,"abstract":"The proportion of very elderly patients in the intensive care unit (ICU) is expected to rise. Furthermore, patients are likely more prone to suffer a cardiac arrest (CA) event within the ICU. The occurrence of intensive care unit cardiac arrest (ICU-CA) is associated with high mortality. To date, the incidence of ICU-CA and its clinical impact on outcome in the very old (≥ 90 years) patients treated is unknown. Retrospective analysis of all consecutive critically ill patients ≥ 90 years admitted to the ICU of a tertiary care university hospital in Hamburg (Germany). All patients suffering ICU-CA were included and CA characteristics and functional outcome was assessed. Clinical course and outcome were assessed and compared between the subgroups of patients with and without ICU-CA. 1,108 critically ill patients aged ≥ 90 years were admitted during the study period. The median age was 92.3 (91.0–94.2) years and 67% (n = 747) were female. 2% (n = 25) of this cohort suffered ICU-CA after a median duration 0.5 (0.2–3.2) days of ICU admission. The presumed cause of ICU-CA was cardiac in 64% (n = 16). The median resuscitation time was 10 (2–15) minutes and the initial rhythm was shockable in 20% (n = 5). Return of spontaneous circulation (ROSC) could be achieved in 68% (n = 17). The cause of ICU admission was primarily medical in the total cohort (ICU-CA: 48% vs. No ICU-CA: 34%, p = 0.13), surgical - planned (ICU-CA: 32% vs. No ICU-CA: 37%, p = 0.61) and surgical - unplanned/emergency (ICU-CA: 43% vs. No ICU-CA: 28%, p = 0.34). The median Charlson Comorbidity Index (CCI) was 2 (1–3) points for patients with ICU-CA and 1 (0–2) for patients without ICU-CA (p = 0.54). Patients with ICU-CA had a higher disease severity according to SAPS II (ICU-CA: 54 vs. No ICU-CA: 36 points, p &lt; 0.001). Patients with ICU-CA had a higher rate of mechanically ventilation (ICU-CA: 64% vs. No ICU-CA: 34%, p &lt; 0.01) and required vasopressor therapy more often (ICU-CA: 88% vs. No ICU-CA: 41%, p &lt; 0.001). The ICU and in-hospital mortality was 88% (n = 22) and 100% (n = 25) in patients with ICU-CA compared to 17% (n = 179) and 28% (n = 306) in patients without ICU-CA. The mortality rate for patients with ICU-CA was observed to be 88% (n = 22) in the ICU and 100% (n = 25) in-hospital. In contrast, patients without ICU-CA had an in-ICU mortality rate of 17% (n = 179) and an in-hospital mortality rate of 28% (n = 306) (both p &lt; 0.001). The occurrence of ICU-CA in very elderly patients is rare but associated with high mortality. Providing CPR in this cohort did not lead to long-term survival at our centre. Very elderly patients admitted to the ICU likely benefit from supportive care only and should probably not be resuscitated due to poor chance of survival and ethical considerations. Providing personalized assurances that care will remain appropriate and in accordance with the patient’s and family’s wishes can optimise compassionate care while avoiding futile life-sustaining interven","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142204682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health care utilization of patients with acute abdominal pain before and after emergency department visits 急性腹痛患者在急诊室就诊前后的医疗利用情况
Pub Date : 2024-08-12 DOI: 10.1186/s13049-024-01237-7
Katharina Verleger, Antje Fischer-Rosinsky, Martin Möckel, Anna Schneider, Anna Slagman, Thomas Keil, Liane Schenk
Acute abdominal pain (AAP) is a major driver for capacity-use in emergency departments (EDs) worldwide. Yet, the health care utilization of patients with AAP before and after the ED remains unclear. The primary objective of this study was to describe adult patients presenting to the ED with AAP and their outpatient care (OC) use before and after the ED. Secondary objectives included description of hospitalization rates, in-hospital mortality, ED re-visits, and exploration of potential risk factors for hospitalization and ED re-visits. For the analysis, we combined routine hospital data from patients who visited 15 EDs in Germany in 2016 with their statutory health insurance OC claims data from 2014 to 2017. Adult patients were included based on a chief complaint or an ED diagnosis indicating unspecific AAP or the Manchester Triage System indicator “Abdominal pain in adults”. Baseline characteristics, ED diagnosis, frequency and reason of hospitalization, frequency and type of prior-OC (prOC) use up to 3 days before and of post-OC use up to 30 days after the ED visit. We identified 28,085 adults aged ≥ 20 years with AAP. 39.8% were hospitalized, 33.9% sought prOC before the ED visit (48.6% of them were hospitalized) and 62.7% sought post-OC up to 30 days after the ED visit. Hospitalization was significantly more likely for elderly patients (aged 65 and above vs. younger; adjusted OR 3.05 [95% CI 2.87; 3.25]), prOC users (1.71 [1.61; 1.90]) and men (1.44 [1.37; 1.52]). In-hospital mortality rate was 3.1% overall. Re-visiting the ED within 30 days was more likely for elderly patients (1.32 [1.13; 1.55) and less likely for those with prOC use (0.37 [0.31; 0.44]). prOC use was associated with more frequent hospitalizations but fewer ED re-visits. ED visits by prOC patients without subsequent hospitalization may indicate difficulties of OC resources to meet the complex diagnostic requirements and expectations of this patient population. Fewer ED re-visits in prOC users indicate effective care in this subgroup.
急性腹痛(AAP)是全球急诊科(ED)容量使用的主要驱动因素。然而,急性腹痛患者在急诊室就诊前后的医疗利用情况仍不清楚。本研究的主要目的是描述因腹痛到急诊科就诊的成年患者及其在急诊科就诊前后的门诊护理(OC)使用情况。次要目标包括描述住院率、院内死亡率、急诊室复诊率,以及探讨住院和急诊室复诊的潜在风险因素。为了进行分析,我们将 2016 年在德国 15 家急诊室就诊的患者的常规医院数据与其 2014 年至 2017 年的法定医疗保险 OC 索赔数据相结合。成人患者的纳入依据是主诉或急诊室诊断为非特异性 AAP 或曼彻斯特分诊系统指标 "成人腹痛"。基线特征、急诊室诊断、住院频率和原因、急诊室就诊前 3 天内事先使用过 OC(prOC)的频率和类型以及急诊室就诊后 30 天内使用过 OC 后的频率和类型。我们确定了 28,085 名年龄≥ 20 岁、患有 AAP 的成年人。39.8%的人住院治疗,33.9%的人在急诊室就诊前寻求 prOC(其中 48.6%的人住院治疗),62.7%的人在急诊室就诊后 30 天内寻求后OC。老年患者(65 岁及以上与年轻患者相比;调整后 OR 值为 3.05 [95% CI 2.87; 3.25])、prOC 使用者(1.71 [1.61; 1.90])和男性(1.44 [1.37; 1.52])更容易住院。总体住院死亡率为 3.1%。老年患者在 30 天内再次到急诊室就诊的可能性更大(1.32 [1.13; 1.55]),而使用 prOC 的患者再次到急诊室就诊的可能性较小(0.37 [0.31; 0.44])。prOC患者在急诊室就诊而没有随后住院,这可能表明OC资源难以满足这类患者复杂的诊断要求和期望。prOC使用者的急诊室复诊次数较少,说明对这一亚群的护理是有效的。
{"title":"Health care utilization of patients with acute abdominal pain before and after emergency department visits","authors":"Katharina Verleger, Antje Fischer-Rosinsky, Martin Möckel, Anna Schneider, Anna Slagman, Thomas Keil, Liane Schenk","doi":"10.1186/s13049-024-01237-7","DOIUrl":"https://doi.org/10.1186/s13049-024-01237-7","url":null,"abstract":"Acute abdominal pain (AAP) is a major driver for capacity-use in emergency departments (EDs) worldwide. Yet, the health care utilization of patients with AAP before and after the ED remains unclear. The primary objective of this study was to describe adult patients presenting to the ED with AAP and their outpatient care (OC) use before and after the ED. Secondary objectives included description of hospitalization rates, in-hospital mortality, ED re-visits, and exploration of potential risk factors for hospitalization and ED re-visits. For the analysis, we combined routine hospital data from patients who visited 15 EDs in Germany in 2016 with their statutory health insurance OC claims data from 2014 to 2017. Adult patients were included based on a chief complaint or an ED diagnosis indicating unspecific AAP or the Manchester Triage System indicator “Abdominal pain in adults”. Baseline characteristics, ED diagnosis, frequency and reason of hospitalization, frequency and type of prior-OC (prOC) use up to 3 days before and of post-OC use up to 30 days after the ED visit. We identified 28,085 adults aged ≥ 20 years with AAP. 39.8% were hospitalized, 33.9% sought prOC before the ED visit (48.6% of them were hospitalized) and 62.7% sought post-OC up to 30 days after the ED visit. Hospitalization was significantly more likely for elderly patients (aged 65 and above vs. younger; adjusted OR 3.05 [95% CI 2.87; 3.25]), prOC users (1.71 [1.61; 1.90]) and men (1.44 [1.37; 1.52]). In-hospital mortality rate was 3.1% overall. Re-visiting the ED within 30 days was more likely for elderly patients (1.32 [1.13; 1.55) and less likely for those with prOC use (0.37 [0.31; 0.44]). prOC use was associated with more frequent hospitalizations but fewer ED re-visits. ED visits by prOC patients without subsequent hospitalization may indicate difficulties of OC resources to meet the complex diagnostic requirements and expectations of this patient population. Fewer ED re-visits in prOC users indicate effective care in this subgroup.","PeriodicalId":501057,"journal":{"name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141941043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1