Polycyclic aromatic hydrocarbons (PAHs) are considered major players in the physics and chemistry of star‐ and planet‐forming regions. The interstellar PAH hypothesis is based on our understanding of the origin of the aromatic infrared bands (AIBs), a set of bright emission features that are now the focus of observations by the James Webb telescope. While AIB carriers are expected to be large free PAHs (50 carbon atoms or more), laboratory analysis of primitive carbonaceous chondrites (CCs) has mainly revealed relatively small PAHs, up to 24 carbon atoms. In this study, we present a comprehensive analysis of aromatic species in bulk samples from the carbonaceous asteroid Ryugu using a surface mass spectrometry technique provided by two‐step laser desorption ionization. The resulting molecular distribution differs significantly from that obtained for a sample from the CC Orgueil, revealing aromatic species extending up to 61 carbon atoms. The species identified are composed of both peri‐condensed PAHs and non‐condensed aromatics. These results directly support the interstellar PAH hypothesis and open up new perspectives on the formation and evolution of organic matter in star‐forming regions and in the solar nebula.Key PointsFirst direct detection of free aromatic species of large sizes with up to 61 carbon atoms in primitive extraterrestrial matter by applying a highly sensitive two‐step laser mass spectrometry analysis to grain samples from the carbonaceous asteroid Ryugu (Hayabusa2 mission).First direct support for the interstellar polycyclic aromatic hydrocarbon (PAH) hypothesis, according to which large free PAHs are responsible for the aromatic emission bands that are major infrared features currently observed by the James Webb Space Telescope.The large aromatic species detected are present in trace amounts and future research is needed to develop sensitive techniques for studying these compounds in sample return missions and meteorites.
{"title":"First direct detection of large polycyclic aromatic hydrocarbons on asteroid (162173) Ryugu samples: An interstellar heritage","authors":"Hassan Sabbah, Ghylaine Quitté, Karine Demyk, Christine Joblin","doi":"10.1002/ntls.20240010","DOIUrl":"https://doi.org/10.1002/ntls.20240010","url":null,"abstract":"<jats:label/>Polycyclic aromatic hydrocarbons (PAHs) are considered major players in the physics and chemistry of star‐ and planet‐forming regions. The interstellar PAH hypothesis is based on our understanding of the origin of the aromatic infrared bands (AIBs), a set of bright emission features that are now the focus of observations by the James Webb telescope. While AIB carriers are expected to be large free PAHs (50 carbon atoms or more), laboratory analysis of primitive carbonaceous chondrites (CCs) has mainly revealed relatively small PAHs, up to 24 carbon atoms. In this study, we present a comprehensive analysis of aromatic species in bulk samples from the carbonaceous asteroid Ryugu using a surface mass spectrometry technique provided by two‐step laser desorption ionization. The resulting molecular distribution differs significantly from that obtained for a sample from the CC Orgueil, revealing aromatic species extending up to 61 carbon atoms. The species identified are composed of both peri‐condensed PAHs and non‐condensed aromatics. These results directly support the interstellar PAH hypothesis and open up new perspectives on the formation and evolution of organic matter in star‐forming regions and in the solar nebula.Key Points<jats:list list-type=\"bullet\"> <jats:list-item>First direct detection of free aromatic species of large sizes with up to 61 carbon atoms in primitive extraterrestrial matter by applying a highly sensitive two‐step laser mass spectrometry analysis to grain samples from the carbonaceous asteroid Ryugu (Hayabusa2 mission).</jats:list-item> <jats:list-item>First direct support for the interstellar polycyclic aromatic hydrocarbon (PAH) hypothesis, according to which large free PAHs are responsible for the aromatic emission bands that are major infrared features currently observed by the James Webb Space Telescope.</jats:list-item> <jats:list-item>The large aromatic species detected are present in trace amounts and future research is needed to develop sensitive techniques for studying these compounds in sample return missions and meteorites.</jats:list-item> </jats:list>","PeriodicalId":501225,"journal":{"name":"Natural Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transient receptor potential vanilloid‐1 (TRPV1) is a capsaicin receptor that employs use‐dependent desensitization to protect highly evolved mammals from noxious heat damage in response to repeated or constant heat stimuli. However, the underlying structural factor or motif has not been precisely resolved. In this computational study, the graph theory‐based grid thermodynamic model was used to reveal how temperature‐dependent noncovalent interactions, as identified in the 3D structures of rat TRPV1, could develop a well‐organized fluidic grid‐like mesh network. This network features various topological grids constrained as thermosensitive rings that range in size from the biggest to the smallest, governing distinct structural and functional traits of the channel in response to different temperature degrees. After discovering that heat unfolding of three specific biggest grids, one in the closed state and two in the open state, respectively, causes the reversible activation at 43°C and thermal inactivation between 56°C and 61°C, a smaller random grid was also found to be responsible for irreversible inactivation and use‐dependent desensitization from the pre‐open closed state within the temperature range of 43°C–61°C. Thus, these two distinct inactivation pathways of TRPV1 may be involved in protecting those mammals against noxious heat damage.Key PointsA perturbation at the protein–water interface was accompanied by partial heat or cold unfolding of the membrane protein.A reversible or irreversible gating transition of an ion channel may result from a specific or random interaction between two active sites, respectively.Kinetically driven protein aggregation was not the cause of thermodynamically trapped irreversible inactivation, but rather a later stage of partial heat‐induced unfolding.
{"title":"Thermoring basis for heat unfolding‐induced inactivation in TRPV1","authors":"Guangyu Wang","doi":"10.1002/ntls.20240008","DOIUrl":"https://doi.org/10.1002/ntls.20240008","url":null,"abstract":"<jats:label/>Transient receptor potential vanilloid‐1 (TRPV1) is a capsaicin receptor that employs use‐dependent desensitization to protect highly evolved mammals from noxious heat damage in response to repeated or constant heat stimuli. However, the underlying structural factor or motif has not been precisely resolved. In this computational study, the graph theory‐based grid thermodynamic model was used to reveal how temperature‐dependent noncovalent interactions, as identified in the 3D structures of rat TRPV1, could develop a well‐organized fluidic grid‐like mesh network. This network features various topological grids constrained as thermosensitive rings that range in size from the biggest to the smallest, governing distinct structural and functional traits of the channel in response to different temperature degrees. After discovering that heat unfolding of three specific biggest grids, one in the closed state and two in the open state, respectively, causes the reversible activation at 43°C and thermal inactivation between 56°C and 61°C, a smaller random grid was also found to be responsible for irreversible inactivation and use‐dependent desensitization from the pre‐open closed state within the temperature range of 43°C–61°C. Thus, these two distinct inactivation pathways of TRPV1 may be involved in protecting those mammals against noxious heat damage.Key Points<jats:list list-type=\"bullet\"> <jats:list-item>A perturbation at the protein–water interface was accompanied by partial heat or cold unfolding of the membrane protein.</jats:list-item> <jats:list-item>A reversible or irreversible gating transition of an ion channel may result from a specific or random interaction between two active sites, respectively.</jats:list-item> <jats:list-item>Kinetically driven protein aggregation was not the cause of thermodynamically trapped irreversible inactivation, but rather a later stage of partial heat‐induced unfolding.</jats:list-item> </jats:list>","PeriodicalId":501225,"journal":{"name":"Natural Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Experimental proof of coherent spatial interference from the logitudinal (1D) Stern-Gerlach (SG) interferometer. (a) A single-shot interference pattern of a thermal cloud with a negligible BEC fraction, with a visibility of 𝑉 = 0.65, clearly showing that a BEC is not needed for the interferometer to work. (b) A multishot image made by averaging 40 consecutive interference images using a BEC (no correction or postselection) with a normalized visibility of 𝑉 = 0.99, proving that the interferometer is phase stable and that no BEC interference (with random fringe position) was involved. (c) Spin oscillations observed at the output of the full-loop SG. The data agrees almost perfectly with the theory developed for a spatial interferometer by the group of Wolfgang Schleich. The excellent agreement again proves that coherent spatial splitting has been achieved. Additional experimental results include clock interferometry and geometrical phase, results which all fit nicely with the theory of a spatial SG interferometer. For a detailed review of the experiments see: Keil, M. et al. (2021). Stern-Gerlach Interferometry with the Atom Chip. In: Friedrich, B., Schmidt-Böcking, H. (eds) Molecular Beams in Physics and Chemistry. Springer, Cham. https://doi.org/10.1007/978-3-030-63963-1_14
对数(1D)斯特恩-格拉赫(SG)干涉仪相干空间干涉的实验证明。(a) 热云的单光干涉图,其 BEC 分数可忽略不计,能见度为 𝑉 = 0.65,清楚地表明干涉仪的工作不需要 BEC。(b) 通过使用 BEC(无校正或后选)对 40 幅连续干涉图像进行平均而得到的多点图像,其归一化能见度为 𝑉 = 0.99,证明干涉仪相位稳定,不涉及 BEC 干涉(随机条纹位置)。(c) 在全环 SG 输出端观察到的自旋振荡。这些数据与沃尔夫冈-施莱希小组为空间干涉仪开发的理论几乎完全吻合。出色的吻合再次证明了相干空间分裂已经实现。其他实验结果包括时钟干涉测量和几何相位,这些结果都非常符合空间 SG 干涉仪的理论。有关实验的详细回顾,请参阅 Keil, M. et al:Keil, M. et al. (2021)。使用原子芯片的斯特恩-格拉赫干涉仪。In:Friedrich, B., Schmidt-Böcking, H. (eds) Molecular Beams in Physics and Chemistry. Springer, Cham.https://doi.org/10.1007/978-3-030-63963-1_14
{"title":"Commentary on “A simple, practical experiment to investigate atomic wavefunction reduction within a Stern‐Gerlach magnet” by Michael Devereux, published in J. Phys. B: At. Mol. Opt. Phys. 57, 152501 (2024), https://doi.org/10.1088/1361‐6455/ad5992","authors":"Ron Folman","doi":"10.1002/ntls.20240025","DOIUrl":"https://doi.org/10.1002/ntls.20240025","url":null,"abstract":"Experimental proof of coherent spatial interference from the logitudinal (1D) Stern-Gerlach (SG) interferometer. (a) A single-shot interference pattern of a thermal cloud with a negligible BEC fraction, with a visibility of 𝑉 = 0.65, clearly showing that a BEC is not needed for the interferometer to work. (b) A multishot image made by averaging 40 consecutive interference images using a BEC (no correction or postselection) with a normalized visibility of 𝑉 = 0.99, proving that the interferometer is phase stable and that no BEC interference (with random fringe position) was involved. (c) Spin oscillations observed at the output of the full-loop SG. The data agrees almost perfectly with the theory developed for a spatial interferometer by the group of Wolfgang Schleich. The excellent agreement again proves that coherent spatial splitting has been achieved. Additional experimental results include clock interferometry and geometrical phase, results which all fit nicely with the theory of a spatial SG interferometer. For a detailed review of the experiments see: Keil, M. et al. (2021). Stern-Gerlach Interferometry with the Atom Chip. In: Friedrich, B., Schmidt-Böcking, H. (eds) Molecular Beams in Physics and Chemistry. Springer, Cham. https://doi.org/10.1007/978-3-030-63963-1_14","PeriodicalId":501225,"journal":{"name":"Natural Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Sandya Narayanswami is a life scientist with a B. Sc (Hons) in Biological Sciences from the University of Leicester, a PhD from the University of St. Andrews, Scotland, followed by postdoctoral training in the Chambon and Hamkalo Labs at the Universities of Strasbourg and California, Irvine. She combines faculty-level research experience at The Jackson Laboratory, Bar Harbor, Maine, with a 25-year track record of fundraising from foundations, corporations, and federal agencies, most recently at the California Institute of Technology. She launched her own consultancy in 2014 and got her pilot's license in 2019 through the Caltech Flying Club. She is currently Chairman of the Board of the General Aviation Awards, the US's oldest awards program in General Aviation, endorsed by the FAA. She has a profound passion for and understanding of science, together with a deep love and knowledge of literature and the humanities.