Pub Date : 2024-02-28DOI: 10.1142/s0219519424500039
KATHARINE NOWAKOWSKI, PHILIPPE CARVALHO, KARIM EL KIRAT, TIEN-TUAN DAO
The elucidation of human locomotion strategies has potential applications in the prevention of sarcopenia and in the reduction of falls. Given the diverse biochemical, mechanical and functional age-related changes seen in the neuro-musculoskeletal system, the decline in motor function is difficult to study experimentally. In this study, we use transfer testing and coupled simulation strategies within a deep reinforcement learning environment to better understand the complex problem of motor control adaptation to age-related changes. Using transfer testing, a 3D musculoskeletal model is separately trained on parameters of the young adult model (Y) for either forward or backward falls after completing two steps forward, and tested using a 30% age-related reduction for all parameters (M_all). This strategy produces a backward fall for a forwardly trained simulation, showing potential sensitivity of these parameters to a given fall direction. Second, a coupled simulation solution is used to simulate recovery from falls by considering the center-of-mass position relative to the base of support. Results for the M_all trained model showed a longer simulation time and a greater vertical pelvis velocity with a maximal value of 4.26m/s. In particular, the results of the coupled simulations clearly show that both the young and M_all condition models respond with a step back and stronger leg extensor activations to propel the model forward to recover from the simulated fall. We developed a novel coupling between transfer testing and coupled simulation strategies to improve upon muscle models for characterizing muscle function, and also to begin testing different hypotheses, such as the strategy and force required to avoid a fall at different limits. This opens new avenues for precision rehabilitation with patient-specific muscle-driven recovery exercises.
{"title":"INSIGHTS INTO HUMAN LOCOMOTION STRATEGIES AND MOTOR LEARNING FOR AN AGEING POPULATION USING TRANSFER TESTING AND COUPLED SIMULATIONS","authors":"KATHARINE NOWAKOWSKI, PHILIPPE CARVALHO, KARIM EL KIRAT, TIEN-TUAN DAO","doi":"10.1142/s0219519424500039","DOIUrl":"https://doi.org/10.1142/s0219519424500039","url":null,"abstract":"<p>The elucidation of human locomotion strategies has potential applications in the prevention of sarcopenia and in the reduction of falls. Given the diverse biochemical, mechanical and functional age-related changes seen in the neuro-musculoskeletal system, the decline in motor function is difficult to study experimentally. In this study, we use transfer testing and coupled simulation strategies within a deep reinforcement learning environment to better understand the complex problem of motor control adaptation to age-related changes. Using transfer testing, a 3D musculoskeletal model is separately trained on parameters of the young adult model (<i>Y</i>) for either forward or backward falls after completing two steps forward, and tested using a 30% age-related reduction for all parameters (<i>M</i>_all). This strategy produces a backward fall for a forwardly trained simulation, showing potential sensitivity of these parameters to a given fall direction. Second, a coupled simulation solution is used to simulate recovery from falls by considering the center-of-mass position relative to the base of support. Results for the <i>M</i>_all trained model showed a longer simulation time and a greater vertical pelvis velocity with a maximal value of 4.26<span><math altimg=\"eq-00001.gif\" display=\"inline\" overflow=\"scroll\"><mspace width=\".17em\"></mspace></math></span><span></span>m/s. In particular, the results of the coupled simulations clearly show that both the young and <i>M</i>_all condition models respond with a step back and stronger leg extensor activations to propel the model forward to recover from the simulated fall. We developed a novel coupling between transfer testing and coupled simulation strategies to improve upon muscle models for characterizing muscle function, and also to begin testing different hypotheses, such as the strategy and force required to avoid a fall at different limits. This opens new avenues for precision rehabilitation with patient-specific muscle-driven recovery exercises.</p>","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140152235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.1142/s0219519424020019
E. P. Pitarch, E. Ng
{"title":"PREFACE — APPLICATION AND PROGRESS OF BIOMECHANICS IN MEDICINE-PART I","authors":"E. P. Pitarch, E. Ng","doi":"10.1142/s0219519424020019","DOIUrl":"https://doi.org/10.1142/s0219519424020019","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-17DOI: 10.1142/s0219519424920039
Wenbo Wang, Shengyu Kuang
{"title":"ERRATUM — ROLE OF THE WOMAC SCORES IN PREOPERATIVE DECISION-MAKING AND ANALYSIS OF KNEE REPLACEMENT FOR KNEE OSTEOARTHRITIS PATIENTS","authors":"Wenbo Wang, Shengyu Kuang","doi":"10.1142/s0219519424920039","DOIUrl":"https://doi.org/10.1142/s0219519424920039","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-13DOI: 10.1142/s0219519424920027
J. Choi, Jieun Park, Junghun Kim, Jongmin Lee
{"title":"ERRATUM — IMPORTANCE OF BODY BALANCE DURING SLEEP: COMPARISON OF FLAT AND TRANSFORMING BEDS","authors":"J. Choi, Jieun Park, Junghun Kim, Jongmin Lee","doi":"10.1142/s0219519424920027","DOIUrl":"https://doi.org/10.1142/s0219519424920027","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139841630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-13DOI: 10.1142/s0219519424920015
Minjeong Kim, Junghun Kim, Jongmin Lee
{"title":"ERRATUM — COMPARISON OF CONVOLUTIONAL NEURAL NETWORK IMAGE CLASSIFICATION PERFORMANCE RELATIVE TO THE AMOUNT OF TRAINING DATA USING CARDIOMEGALY X-RAY IMAGES","authors":"Minjeong Kim, Junghun Kim, Jongmin Lee","doi":"10.1142/s0219519424920015","DOIUrl":"https://doi.org/10.1142/s0219519424920015","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139781079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-13DOI: 10.1142/s0219519424920015
Minjeong Kim, Junghun Kim, Jongmin Lee
{"title":"ERRATUM — COMPARISON OF CONVOLUTIONAL NEURAL NETWORK IMAGE CLASSIFICATION PERFORMANCE RELATIVE TO THE AMOUNT OF TRAINING DATA USING CARDIOMEGALY X-RAY IMAGES","authors":"Minjeong Kim, Junghun Kim, Jongmin Lee","doi":"10.1142/s0219519424920015","DOIUrl":"https://doi.org/10.1142/s0219519424920015","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-13DOI: 10.1142/s0219519424920027
J. Choi, Jieun Park, Junghun Kim, Jongmin Lee
{"title":"ERRATUM — IMPORTANCE OF BODY BALANCE DURING SLEEP: COMPARISON OF FLAT AND TRANSFORMING BEDS","authors":"J. Choi, Jieun Park, Junghun Kim, Jongmin Lee","doi":"10.1142/s0219519424920027","DOIUrl":"https://doi.org/10.1142/s0219519424920027","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139781700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HBPGEO: An application system for analyzing and visualizing gene expression data of hypertension","authors":"Zongjin Li, Liqin Tian, Jiyu Yang, Zeyu Jia, Chengying Yan, Wenjing Qu, Xinyue Ma, Changxin Song, Xiaoming Wu","doi":"10.1142/s021951942440013x","DOIUrl":"https://doi.org/10.1142/s021951942440013x","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.1142/s0219519424400165
Haiyang Luan, Benteng Ma, Zhangzhen Shi, Yu Liu
{"title":"Bladder wall segmentation and cancer assessment using attention U-net with adversarial mechanism and two-layer level sets","authors":"Haiyang Luan, Benteng Ma, Zhangzhen Shi, Yu Liu","doi":"10.1142/s0219519424400165","DOIUrl":"https://doi.org/10.1142/s0219519424400165","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing tongue region segmentation through self-attention and transformer-based","authors":"Yihua Song, Can Li, Xia Zhang, Zhen Liu, Ningning Song, Zuojian Zhou","doi":"10.1142/s0219519424400098","DOIUrl":"https://doi.org/10.1142/s0219519424400098","url":null,"abstract":"","PeriodicalId":50135,"journal":{"name":"Journal of Mechanics in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139810187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号