Pub Date : 2026-12-01Epub Date: 2026-02-09DOI: 10.1080/14767058.2025.2582375
Jagrati Chopra, Charlotte Maden, Isabel Howlett, Helen Perry, Alexandra J Kermack, Mehtap Ozbey Arabaci, Adriane Chapman, Kai Yang, Diego Altamirano, Ying Cheong
Objective: The benefit of interventions to improve neonatal outcomes of preterm birth (PTB) must be balanced with the associated fetal and maternal risks. Artificial intelligence (AI) could be used to assess uterine contractions and consequently help to predict PTB. This paper aims to assess the predictive accuracy and applicability of AI models currently using uterine contractions in PTB prediction.
Methods: A systematic Embase, Medline, Pubmed and Web of Science review was conducted using PRISMA guidelines. Eligible studies assessed EHG or time-series data using AI methods, including deep learning/machine learning/neural networks to predict PTB. Data on AI model performance measures, validity, and applicability were collected. Results are reported as a narrative review due to study heterogeneity. Bias was assessed using the PROBAST framework.
Results: The studies used various Electrohysterography (EHG) contractility features and/or classifiers for AI analysis and varying performance measures to assess predictive accuracy for PTB. A wide range of EHG features were assessed included temporal, spectral, entropy and topological features. A total of 53 records were identified for inclusion. Of these, 18 examined EHG features, 22 assessed AI classifiers, and 3 tested both. Excellent classification performance (ACC and/or AUC ≥0.9) were reported by 38.8% (7/18) of studies examining EHG features and 86.3% (19/22) of studies assessing AI classifiers. Non-linear features outperformed linear features, and deep-learning models such as neural networks were the highest-performing classifiers. Bias assessment showed 86.7% (46/53) had an unclear or high risk of bias. Key concerns include unbalanced data, small sample size and lack of validity outside of sampled datasets.
Conclusion: Non-linear features and DL models offer superior results. However, we did not find evidence of external validation, thus the applicability of models in uterine contraction assessment for the prediction of PTB remains limited. Future research requires an emphasis on clinical data integration within high-quality studies, as well as more more studies focusing on early PTB detection.
目的：改善新生儿早产（PTB）结局的干预措施的益处必须与相关的胎儿和母体风险相平衡。人工智能（AI）可用于评估子宫收缩，从而有助于预测PTB。本文旨在评估目前使用子宫收缩预测PTB的AI模型的预测准确性和适用性。方法：采用PRISMA指南对Embase、Medline、Pubmed和Web of Science进行系统综述。合格的研究使用人工智能方法评估EHG或时间序列数据，包括深度学习/机器学习/神经网络来预测PTB。收集了人工智能模型性能指标、有效性和适用性的数据。由于研究异质性，结果报告为叙述性综述。使用PROBAST框架评估偏倚。结果：这些研究使用了各种子宫电图（EHG）收缩性特征和/或分类器进行人工智能分析和不同的性能测量来评估PTB的预测准确性。广泛的EHG特征被评估，包括时间、光谱、熵和拓扑特征。共有53条记录被确定纳入。其中，18项测试了EHG特征，22项评估了人工智能分类器，3项测试了两者。38.8%（7/18）检查EHG特征的研究和86.3%（19/22）评估AI分类器的研究报告了出色的分类性能（ACC和/或AUC≥0.9）。非线性特征优于线性特征，神经网络等深度学习模型是表现最好的分类器。偏倚评估显示86.7%（46/53）存在不明确或高偏倚风险。关键问题包括数据不平衡、样本规模小以及样本数据集之外缺乏有效性。结论：非线性特征和深度学习模型具有较好的效果。然而，我们没有发现外部验证的证据，因此模型在子宫收缩评估中预测PTB的适用性仍然有限。未来的研究需要强调高质量研究中的临床数据整合，以及更多关注肺结核早期检测的研究。
{"title":"Use of uterine activity to predict preterm birth by artificial intelligence assisted models: a narrative systematic review.","authors":"Jagrati Chopra, Charlotte Maden, Isabel Howlett, Helen Perry, Alexandra J Kermack, Mehtap Ozbey Arabaci, Adriane Chapman, Kai Yang, Diego Altamirano, Ying Cheong","doi":"10.1080/14767058.2025.2582375","DOIUrl":"https://doi.org/10.1080/14767058.2025.2582375","url":null,"abstract":"<p><strong>Objective: </strong>The benefit of interventions to improve neonatal outcomes of preterm birth (PTB) must be balanced with the associated fetal and maternal risks. Artificial intelligence (AI) could be used to assess uterine contractions and consequently help to predict PTB. This paper aims to assess the predictive accuracy and applicability of AI models currently using uterine contractions in PTB prediction.</p><p><strong>Methods: </strong>A systematic Embase, Medline, Pubmed and Web of Science review was conducted using PRISMA guidelines. Eligible studies assessed EHG or time-series data using AI methods, including deep learning/machine learning/neural networks to predict PTB. Data on AI model performance measures, validity, and applicability were collected. Results are reported as a narrative review due to study heterogeneity. Bias was assessed using the PROBAST framework.</p><p><strong>Results: </strong>The studies used various Electrohysterography (EHG) contractility features and/or classifiers for AI analysis and varying performance measures to assess predictive accuracy for PTB. A wide range of EHG features were assessed included temporal, spectral, entropy and topological features. A total of 53 records were identified for inclusion. Of these, 18 examined EHG features, 22 assessed AI classifiers, and 3 tested both. Excellent classification performance (ACC and/or AUC ≥0.9) were reported by 38.8% (7/18) of studies examining EHG features and 86.3% (19/22) of studies assessing AI classifiers. Non-linear features outperformed linear features, and deep-learning models such as neural networks were the highest-performing classifiers. Bias assessment showed 86.7% (46/53) had an unclear or high risk of bias. Key concerns include unbalanced data, small sample size and lack of validity outside of sampled datasets.</p><p><strong>Conclusion: </strong>Non-linear features and DL models offer superior results. However, we did not find evidence of external validation, thus the applicability of models in uterine contraction assessment for the prediction of PTB remains limited. Future research requires an emphasis on clinical data integration within high-quality studies, as well as more more studies focusing on early PTB detection.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2582375"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-02-17DOI: 10.1080/14767058.2026.2629688
Danyang Qu, Yajun Zhang, Shanshan Wang, Haiping Dou, Yufang Xiu, Yue Dong, Yuqian Wang, Liu Yang
<p><strong>Background: </strong>Despite the lack of data from randomized controlled trials, studies have indicated that labor anesthesia may be associated with neonatal asphyxia, neonatal respiratory distress and adverse neonatal neurological outcomes. Therefore, we performed a two-sample Mendelian randomization analysis to explore the potential causal relationships between labor anesthesia methods and adverse neonatal outcomes.</p><p><strong>Method: </strong>We collected genome-wide association study (GWAS) data, including on spinal (<i>n</i> = 3,780), epidural (<i>n</i> = 3,970), and other labor anesthesia methods (<i>n</i> = 4,094), as well as neonatal asphyxia (<i>n</i> = 499,936), neonatal respiratory distress (NRDS) (<i>n</i> = 499,974) and cerebral palsy (<i>n</i> = 496,311), attention-deficit hyperactivity disorder (ADHD) (<i>n</i> = 495,160), and intellectual disability (<i>n</i> = 363,663). Data on different delivery analgesia methods that were sourced from the Integrative Epidemiology Unit (IEU) OpenGWAS project were used as exposure data. Neonatal asphyxia, neonatal respiratory distress and neurological adverse outcomes sourced from the FinnGen consortium R12 were used as the outcome data. A two-sample MR was used to evaluate the effects of different delivery analgesia methods on neonatal asphyxia, neonatal respiratory distress and three adverse neurological outcomes in newborns to determine the existence of a causal relationship between them. The inverse-variance weighted (IVW) method was used for MR analysis and a series of sensitivity analyses were conducted. The MR-Egger intercept test was used to assess directional horizontal pleiotropy. Heterogeneity was evaluated using the Cochran's Q statistic. Instrument strength was assessed using F-statistics, with values greater than 10 indicating a low risk of weak instrument bias.</p><p><strong>Results: </strong>Spinal, epidural, and other methods of labor anesthesia were not found to be strongly associated with neonatal asphyxia (OR = 0.707, 95% CI = 0.176-2.832, <i>p</i> = 0.624; OR = 3.222, 95% CI = 0.973-10.664, <i>p</i> = 0.055; OR = 0.732, 95% CI = 0.166-3.230, <i>p</i> = 0.681, respectively), NRDS (OR = 0.941, 95% CI = 0.381-2.321, <i>p</i> = 0.894; OR = 1.116, 95% CI = 0.505-2.465, <i>p</i> = 0.786; OR = 0.801, 95% CI = 0.329-1.950, <i>p</i> = 0.624), cerebral palsy (OR = 0.930, 95% CI = 0.442-1.959, <i>p</i> = 0.849; OR = 0.636, 95% CI = 0.318-1.271, <i>p</i> = 0.200; OR = 1.112, 95% CI = 0.544-2.271, <i>p</i> = 0.771, respectively), intellectual disability (OR = 1.586, 95% CI = 0.917-2.743, <i>p</i> = 0.099; OR = 0.809, 95% CI = 0.454-1.440, <i>p</i> = 0.471; OR = 0.774, 95% CI = 0.380-1.575, <i>p</i> = 0.479, respectively), or attention deficit hyperactivity disorder (OR = 0.827, 95% CI = 0.621-1.102, <i>p</i> = 0.195; OR = 0.998, 95% CI = 0.739-1.346, <i>p</i> = 0.988; OR = 1.136, 95% CI = 0.771-1.673, <i>p</i> = 0.519, respectively). The sensitivity analyses, performed with
背景：尽管缺乏随机对照试验的数据，但研究表明，分娩麻醉可能与新生儿窒息、新生儿呼吸窘迫和新生儿神经系统不良预后有关。因此，我们进行了一项双样本孟德尔随机分析，以探讨分娩麻醉方法与不良新生儿结局之间的潜在因果关系。方法：我们收集全基因组关联研究（GWAS）数据，包括脊髓（n = 3780）、硬膜外（n = 3970）和其他分娩麻醉方法（n = 4094），以及新生儿窒息（n = 499,936）、新生儿呼吸窘迫（n = 499,974）和脑瘫（n = 496,311）、注意缺陷多动障碍（n = 495,160）和智力残疾（n = 363,663）。来自综合流行病学单位（IEU） OpenGWAS项目的不同分娩镇痛方法的数据被用作暴露数据。新生儿窒息、新生儿呼吸窘迫和神经系统不良结局数据来源于FinnGen联盟R12。采用双样本MR评估不同分娩镇痛方法对新生儿窒息、新生儿呼吸窘迫和新生儿三种不良神经结局的影响，以确定它们之间是否存在因果关系。采用反方差加权（IVW）方法进行MR分析，并进行一系列敏感性分析。MR-Egger截距检验用于评估定向水平多效性。采用Cochran’s Q统计量评估异质性。使用f统计量评估工具强度，值大于10表示弱工具偏倚风险较低。结果:脊髓硬膜外,其他方法劳动麻醉没有发现与新生儿窒息(OR = 0.707, 95% CI -2.832 = 0.176, p = 0.624;或= 3.222,95% CI -10.664 = 0.973, p = 0.055;或= 0.732,95% CI -3.230 = 0.166, p = 0.681),”(OR = 0.941, 95% CI -2.321 = 0.381, p = 0.894;或= 1.116,95% CI -2.465 = 0.505, p = 0.786;或= 0.801,95% CI -1.950 = 0.329, p = 0.624),脑瘫(OR = 0.930, 95% CI -1.959 = 0.442, p = 0.849;OR = 0.636, 95% CI = 0.318-1.271, p = 0.200；或= 1.112,95% CI = 0.544 - -2.271, p = 0.771,分别),智力障碍(OR = 1.586, 95% CI -2.743 = 0.917, p = 0.099;或= 0.809,95% CI -1.440 = 0.454, p = 0.471;或= 0.774,95% CI -1.575 = 0.380, p = 0.479),或注意力缺陷多动障碍(OR = 0.827, 95% CI -1.102 = 0.621, p = 0.195;或= 0.998,95% CI -1.346 = 0.739, p = 0.988;或= 1.136,95% CI -1.673 = 0.771, p = 0.519)。通过Cochran’s Q检验和MR-Egger截距进行的敏感性分析显示，几乎没有证据表明存在实质性异质性或定向水平多效性。结论：我们基于遗传数据的MR研究不支持不同分娩麻醉方法与新生儿窒息、新生儿呼吸窘迫或新生儿不良神经预后之间存在因果关系。因此，可以根据产妇的需要和情况选择分娩镇痛方法，而不会增加相关风险。
{"title":"Mendelian randomization analysis of labor anesthesia and adverse neonatal outcomes.","authors":"Danyang Qu, Yajun Zhang, Shanshan Wang, Haiping Dou, Yufang Xiu, Yue Dong, Yuqian Wang, Liu Yang","doi":"10.1080/14767058.2026.2629688","DOIUrl":"https://doi.org/10.1080/14767058.2026.2629688","url":null,"abstract":"<p><strong>Background: </strong>Despite the lack of data from randomized controlled trials, studies have indicated that labor anesthesia may be associated with neonatal asphyxia, neonatal respiratory distress and adverse neonatal neurological outcomes. Therefore, we performed a two-sample Mendelian randomization analysis to explore the potential causal relationships between labor anesthesia methods and adverse neonatal outcomes.</p><p><strong>Method: </strong>We collected genome-wide association study (GWAS) data, including on spinal (<i>n</i> = 3,780), epidural (<i>n</i> = 3,970), and other labor anesthesia methods (<i>n</i> = 4,094), as well as neonatal asphyxia (<i>n</i> = 499,936), neonatal respiratory distress (NRDS) (<i>n</i> = 499,974) and cerebral palsy (<i>n</i> = 496,311), attention-deficit hyperactivity disorder (ADHD) (<i>n</i> = 495,160), and intellectual disability (<i>n</i> = 363,663). Data on different delivery analgesia methods that were sourced from the Integrative Epidemiology Unit (IEU) OpenGWAS project were used as exposure data. Neonatal asphyxia, neonatal respiratory distress and neurological adverse outcomes sourced from the FinnGen consortium R12 were used as the outcome data. A two-sample MR was used to evaluate the effects of different delivery analgesia methods on neonatal asphyxia, neonatal respiratory distress and three adverse neurological outcomes in newborns to determine the existence of a causal relationship between them. The inverse-variance weighted (IVW) method was used for MR analysis and a series of sensitivity analyses were conducted. The MR-Egger intercept test was used to assess directional horizontal pleiotropy. Heterogeneity was evaluated using the Cochran's Q statistic. Instrument strength was assessed using F-statistics, with values greater than 10 indicating a low risk of weak instrument bias.</p><p><strong>Results: </strong>Spinal, epidural, and other methods of labor anesthesia were not found to be strongly associated with neonatal asphyxia (OR = 0.707, 95% CI = 0.176-2.832, <i>p</i> = 0.624; OR = 3.222, 95% CI = 0.973-10.664, <i>p</i> = 0.055; OR = 0.732, 95% CI = 0.166-3.230, <i>p</i> = 0.681, respectively), NRDS (OR = 0.941, 95% CI = 0.381-2.321, <i>p</i> = 0.894; OR = 1.116, 95% CI = 0.505-2.465, <i>p</i> = 0.786; OR = 0.801, 95% CI = 0.329-1.950, <i>p</i> = 0.624), cerebral palsy (OR = 0.930, 95% CI = 0.442-1.959, <i>p</i> = 0.849; OR = 0.636, 95% CI = 0.318-1.271, <i>p</i> = 0.200; OR = 1.112, 95% CI = 0.544-2.271, <i>p</i> = 0.771, respectively), intellectual disability (OR = 1.586, 95% CI = 0.917-2.743, <i>p</i> = 0.099; OR = 0.809, 95% CI = 0.454-1.440, <i>p</i> = 0.471; OR = 0.774, 95% CI = 0.380-1.575, <i>p</i> = 0.479, respectively), or attention deficit hyperactivity disorder (OR = 0.827, 95% CI = 0.621-1.102, <i>p</i> = 0.195; OR = 0.998, 95% CI = 0.739-1.346, <i>p</i> = 0.988; OR = 1.136, 95% CI = 0.771-1.673, <i>p</i> = 0.519, respectively). The sensitivity analyses, performed with ","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2629688"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-02-15DOI: 10.1080/14767058.2026.2627751
Neslihan Bezirganoglu Altuntas, Sema Baki Yıldırım
Objective: To evaluate the role of transvaginal and transabdominal cervical length (CL) measurements at 37 weeks of gestation in predicting the risk of prolonged pregnancy among nulliparous women.
Methods: A retrospective cohort study was conducted between February 2022 and June 2024 at a regional tertiary maternity hospital. Transvaginal (TVS) and transabdominal sonography (TAS) were performed in low-risk nulliparous patients at 37 weeks of gestation. Patients were categorized into two groups based on delivery time: <41 weeks (term) and ≥41 weeks (late-term). Demographic, obstetric, and ultrasonographic parameters were compared between groups. Logistic regression was used to identify independent predictors of late-term delivery. Agreement between TVS and TAS measurements was assessed using Bland-Altman analysis. Statistical analyses were performed using SPSS software (version 27.0; IBM SPSS Inc., Chicago, IL, USA) and a p value < 0.05 was considered statistically significant.
Results: A total of 179 patients were included in the study. Of these, 19 (10.6%) were classified as late-term group, while 160 (89.4%) were classified as term group. Maternal age and BMI were similar between groups. The median CL was higher in the late-term group by both TVS and TAS; however, only TVS-CL remained statistically significant (p = 0.032) in the late-term group. Bland-Altman analysis showed acceptable agreement between TAS and TVS measurements with a mean difference of 1.47 mm and 95% limits of agreement ranging from -6.8 to 9.8 mm. After adjusting for potential confounders, a longer TVS-CL was independently associated with an increased risk of late-term delivery (adjusted OR = 1.26; 95% CI 1.01-1.58). A positive correlation was observed between measured transvaginal CL at 37 weeks and gestational age at delivery.
Conclusion: A longer cervical length measured by transvaginal sonography at 37 weeks was independently associated with an increased risk of late-term delivery. Our findings demonstrate the potential value of standardized ultrasonographic assessment in identifying women at risk of prolonged pregnancy, which could help optimize perinatal outcomes.
{"title":"Can transvaginal and transabdominal cervical length measurements at 37 weeks predict the risk of prolonged pregnancy?","authors":"Neslihan Bezirganoglu Altuntas, Sema Baki Yıldırım","doi":"10.1080/14767058.2026.2627751","DOIUrl":"https://doi.org/10.1080/14767058.2026.2627751","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the role of transvaginal and transabdominal cervical length (CL) measurements at 37 weeks of gestation in predicting the risk of prolonged pregnancy among nulliparous women.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted between February 2022 and June 2024 at a regional tertiary maternity hospital. Transvaginal (TVS) and transabdominal sonography (TAS) were performed in low-risk nulliparous patients at 37 weeks of gestation. Patients were categorized into two groups based on delivery time: <41 weeks (term) and ≥41 weeks (late-term). Demographic, obstetric, and ultrasonographic parameters were compared between groups. Logistic regression was used to identify independent predictors of late-term delivery. Agreement between TVS and TAS measurements was assessed using Bland-Altman analysis. Statistical analyses were performed using SPSS software (version 27.0; IBM SPSS Inc., Chicago, IL, USA) and a <i>p</i> value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>A total of 179 patients were included in the study. Of these, 19 (10.6%) were classified as late-term group, while 160 (89.4%) were classified as term group. Maternal age and BMI were similar between groups. The median CL was higher in the late-term group by both TVS and TAS; however, only TVS-CL remained statistically significant (<i>p</i> = 0.032) in the late-term group. Bland-Altman analysis showed acceptable agreement between TAS and TVS measurements with a mean difference of 1.47 mm and 95% limits of agreement ranging from -6.8 to 9.8 mm. After adjusting for potential confounders, a longer TVS-CL was independently associated with an increased risk of late-term delivery (adjusted OR = 1.26; 95% CI 1.01-1.58). A positive correlation was observed between measured transvaginal CL at 37 weeks and gestational age at delivery.</p><p><strong>Conclusion: </strong>A longer cervical length measured by transvaginal sonography at 37 weeks was independently associated with an increased risk of late-term delivery. Our findings demonstrate the potential value of standardized ultrasonographic assessment in identifying women at risk of prolonged pregnancy, which could help optimize perinatal outcomes.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2627751"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2025-12-16DOI: 10.1080/14767058.2025.2601929
Mem Arjen Yıldırım, Bülent Kurkut, Barış Boza, İbrahim Polat
Background: To evaluate the feasibility and safety of performing myomectomy during cesarean delivery using a novel bleeding-reducing suture technique.
Methods: This retrospective cohort study included pregnant women with intramural uterine fibroids. A total of 120 patients were divided into two groups: Group A consisted of women who underwent myomectomy during cesarean section between January 2020 and June 2024, and Group B included women who underwent cesarean section alone without myomectomy. The following data were obtained from hospital records and compared between the groups: maternal age, gravidity, parity, myoma size, gestational age at time, preoperative and postoperative hemoglobin (Hb) levels, need for blood transfusion, hospital stay, and duration of surgery. The primary outcome of the study was the change in Hb levels before and after the operation.
Results: The demographic and laboratory characteristics of 120 pregnant women with intramural leiomyomas who underwent either cesarean myomectomy or cesarean section alone were analyzed. Of these, 60 underwent cesarean section alone, while 60 underwent cesarean section with myomectomy. No statistically significant difference was found between the two groups in terms of preoperative Hb, postoperative 24-hour Hb, or Hb decrease (p = .240, p = .270, and p = .420, respectively). Similarly, there was no significant difference in operation duration (p = .160). A weak but statistically significant negative correlation was observed between myoma size and gestational age at delivery (r = -0.21, p = .0009). No statistically significant correlations were found between myoma size and either operation time or hospital stay.
Conclusion: Cesarean myomectomy appears to be a feasible and safe option when performed using the bleeding-reducing uterine isthmic circumferential suture technique. However, further multicenter studies with larger sample sizes are required to confirm these findings before recommending cesarean myomectomy as a routine approach.
背景：探讨一种新型止血缝合技术在剖宫产术中进行子宫肌瘤切除术的可行性和安全性。方法：本回顾性队列研究纳入子宫壁内肌瘤孕妇。120例患者被分为两组：A组为2020年1月至2024年6月期间在剖宫产术中行子宫肌瘤切除术的女性，B组为仅行剖宫产术但未行子宫肌瘤切除术的女性。从医院记录中获得以下数据，并在两组之间进行比较：产妇年龄、妊娠、胎次、肌瘤大小、当时胎龄、术前和术后血红蛋白（Hb）水平、输血需求、住院时间和手术持续时间。研究的主要结果是手术前后Hb水平的变化。结果：分析了120例剖宫产子宫肌瘤切除术或单独剖宫产的子宫肌瘤孕妇的人口学和实验室特征。其中，单独剖宫产60例，子宫肌瘤切除术60例。两组患者术前Hb、术后24小时Hb、Hb下降量差异无统计学意义(p =。240, p =。270, p =。420年,分别)。同样，两组手术时间无显著差异（p = 0.160）。子宫肌瘤大小与分娩时胎龄呈微弱但有统计学意义的负相关（r = -0.21, p = .0009）。肌瘤大小与手术时间和住院时间均无统计学意义的相关性。结论：剖宫产肌瘤切除术采用减少出血的子宫峡部环缝技术是一种可行和安全的选择。然而，在推荐剖宫产子宫肌瘤切除术作为常规方法之前，需要进一步的多中心研究和更大的样本量来证实这些发现。
{"title":"Outcomes of cesarean myomectomy using novel and safe uterine isthmic circumferential technique.","authors":"Mem Arjen Yıldırım, Bülent Kurkut, Barış Boza, İbrahim Polat","doi":"10.1080/14767058.2025.2601929","DOIUrl":"https://doi.org/10.1080/14767058.2025.2601929","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the feasibility and safety of performing myomectomy during cesarean delivery using a novel bleeding-reducing suture technique.</p><p><strong>Methods: </strong>This retrospective cohort study included pregnant women with intramural uterine fibroids. A total of 120 patients were divided into two groups: Group A consisted of women who underwent myomectomy during cesarean section between January 2020 and June 2024, and Group B included women who underwent cesarean section alone without myomectomy. The following data were obtained from hospital records and compared between the groups: maternal age, gravidity, parity, myoma size, gestational age at time, preoperative and postoperative hemoglobin (Hb) levels, need for blood transfusion, hospital stay, and duration of surgery. The primary outcome of the study was the change in Hb levels before and after the operation.</p><p><strong>Results: </strong>The demographic and laboratory characteristics of 120 pregnant women with intramural leiomyomas who underwent either cesarean myomectomy or cesarean section alone were analyzed. Of these, 60 underwent cesarean section alone, while 60 underwent cesarean section with myomectomy. No statistically significant difference was found between the two groups in terms of preoperative Hb, postoperative 24-hour Hb, or Hb decrease (<i>p</i> = .240, <i>p</i> = .270, and <i>p</i> = .420, respectively). Similarly, there was no significant difference in operation duration (<i>p</i> = .160). A weak but statistically significant negative correlation was observed between myoma size and gestational age at delivery (<i>r</i> = -0.21, <i>p</i> = .0009). No statistically significant correlations were found between myoma size and either operation time or hospital stay.</p><p><strong>Conclusion: </strong>Cesarean myomectomy appears to be a feasible and safe option when performed using the bleeding-reducing uterine isthmic circumferential suture technique. However, further multicenter studies with larger sample sizes are required to confirm these findings before recommending cesarean myomectomy as a routine approach.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2601929"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: A traumatic birth experience can have profound and enduring negative consequences on both maternal and neonatal health and well-being. Although Maternal Empowerment Training (MET) has been applied in other maternal contexts, its specific efficacy on the combination of maternal-infant attachment, breastfeeding self-efficacy, and delivery preference among mothers experiencing a traumatic birth remains unclear. This study aimed to evaluate the effectiveness of MET on these outcomes in this population.
Materials and methods: This randomized controlled trial was conducted in 2023 at Payambar-e Azam and Afzalipour hospitals in Kerman, Iran. Seventy mothers with a history of birth trauma were enrolled, with 35 participants assigned to the intervention group and 35 to the control group. Convenience sampling was used, and participants were randomly allocated using block randomization. Assessors were blinded to group allocation during data collection and analysis. Research tools included a demographic questionnaire, the Mother-to-Infant Bonding Scale (MIBS), the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF), and a checklist assessing preference for cesarean delivery; all instruments are valid and reliable. Data were collected at baseline and two weeks after the last intervention session. The intervention group attended four sessions of Motivational Enhancement Therapy (one face-to-face and three online individual sessions), while the control group received routine postpartum care. Data were analyzed using SPSS-21.
Results: After controlling for baseline differences using ANCOVA, the MET group showed a significant improvement in mother-infant attachment (lower MIBS score), a significant increase in breastfeeding self-efficacy, and a significant reduction in the preference for cesarean delivery compared to the control group (p < 0.0001 for all).
Conclusion: Given the effectiveness of MET, its application is recommended for mothers with traumatic birth experiences to improve breastfeeding self-efficacy and maternal-infant attachment, and to decrease preference for Ce-section.
{"title":"Effects of motivational enhancement therapy on mother-infant attachment, breastfeeding self-efficacy, and cesarean delivery preference following a traumatic birth: a randomized controlled trial in southeast Iran.","authors":"Zahra Kheirandish, Atefeh Ahmadi, Moghaddameh Mirzaee, Zahra Shad, Firoozeh Mirzaee","doi":"10.1080/14767058.2025.2602293","DOIUrl":"10.1080/14767058.2025.2602293","url":null,"abstract":"<p><strong>Introduction: </strong>A traumatic birth experience can have profound and enduring negative consequences on both maternal and neonatal health and well-being. Although Maternal Empowerment Training (MET) has been applied in other maternal contexts, its specific efficacy on the combination of maternal-infant attachment, breastfeeding self-efficacy, and delivery preference among mothers experiencing a traumatic birth remains unclear. This study aimed to evaluate the effectiveness of MET on these outcomes in this population.</p><p><strong>Materials and methods: </strong>This randomized controlled trial was conducted in 2023 at Payambar-e Azam and Afzalipour hospitals in Kerman, Iran. Seventy mothers with a history of birth trauma were enrolled, with 35 participants assigned to the intervention group and 35 to the control group. Convenience sampling was used, and participants were randomly allocated using block randomization. Assessors were blinded to group allocation during data collection and analysis. Research tools included a demographic questionnaire, the Mother-to-Infant Bonding Scale (MIBS), the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF), and a checklist assessing preference for cesarean delivery; all instruments are valid and reliable. Data were collected at baseline and two weeks after the last intervention session. The intervention group attended four sessions of Motivational Enhancement Therapy (one face-to-face and three online individual sessions), while the control group received routine postpartum care. Data were analyzed using SPSS-21.</p><p><strong>Results: </strong>After controlling for baseline differences using ANCOVA, the MET group showed a significant improvement in mother-infant attachment (lower MIBS score), a significant increase in breastfeeding self-efficacy, and a significant reduction in the preference for cesarean delivery compared to the control group (<i>p</i> < 0.0001 for all).</p><p><strong>Conclusion: </strong>Given the effectiveness of MET, its application is recommended for mothers with traumatic birth experiences to improve breastfeeding self-efficacy and maternal-infant attachment, and to decrease preference for Ce-section.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2602293"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p><strong>Introduction: </strong>Prematurity remains a leading cause of neonatal morbidity and mortality, yet the molecular mechanisms underlying functional immaturity at birth are poorly understood. To our knowledge, no study has conducted a proteomic analysis of whole umbilical cords spanning a full range of gestational ages, including infants born at the periviable gestational age (22-25 weeks). Identifying protein expression patterns that correlate with gestational maturity may offer key insights into the molecular drivers of vulnerability in preterm neonates, particularly in the domains of immune and organ development. In this study, we applied data-independent acquisition (DIA)-based mass spectrometry to profile the proteomes of umbilical cords from neonates born between 22 and 40 weeks of gestation. Our aims were to establish the feasibility of this approach and to characterize gestational age-dependent protein expression patterns with relevance to neonatal development and immune maturation.</p><p><strong>Methods: </strong>Umbilical cord samples were obtained from neonates admitted to the Neonatal Intensive Care Unit of the University of Tokyo Hospital. Fresh umbilical cord segments approximately 5 cm in length were collected immediately after delivery. Subsequently, the cords were sectioned into 1 cm fragments, snap-frozen at -80°C, and stored until DIA proteomic analysis. For quantitative proteomics data obtained by DIA, gene symbols were assigned to each protein, and the expression values were transformed into <i>z</i>-scores within each sample. To evaluate temporal changes across four time points, we performed time-course analysis. The Jonckheere-Terpstra test was used to assess the overall monotonic trend across the four time points within each gene set. Gene Ontology (GO) enrichment analysis was performed using Metascape for each expression pattern obtained above.</p><p><strong>Results: </strong>A total of 6,801 proteins were identified from umbilical cord tissues collected from 15 neonates divided into four gestational age groups: 22-25 weeks (<i>n</i> = 4, median birth weight 634 grams (interquartile range [IQR]: 468.5-690)), 26-30 weeks (<i>n</i> = 4, median birth weight 1008 g (IQR: 678.5-1140.8)), 31-34 weeks (<i>n</i> = 3, median birth weight 1521 g (IQR: 1389-1600)), and 35-40 weeks (<i>n</i> = 4, median birth weight 2477 g (IQR: 1858-2677.3)). Proteins involved in immune responses, especially those mediating B cell function, were significantly upregulated with advancing gestational age, indicating progressive immune system maturation (22-25 weeks vs 35-40 weeks, <i>p</i> < 0.01). In contrast, proteins related to mRNA processing, cytoplasmic translation, and ribonucleoprotein complex biogenesis showed inverse trends, suggesting elevated biosynthetic activity in extremely preterm neonates (22-25 weeks vs 35-40 weeks, <i>p</i> < 0.01). Protein markers associated with organ development exhibited heterogeneous trajectories.</p><p
前言：早产仍然是新生儿发病率和死亡率的主要原因，然而，出生时功能不成熟的分子机制尚不清楚。据我们所知，目前还没有研究对全胎龄的全脐带进行蛋白质组学分析，包括围生胎龄（22-25周）出生的婴儿。识别与妊娠成熟度相关的蛋白表达模式可能为早产儿易感性的分子驱动因素提供关键见解，特别是在免疫和器官发育领域。在这项研究中，我们应用基于数据独立采集（DIA）的质谱分析方法分析了妊娠22至40周出生的新生儿脐带的蛋白质组。我们的目的是建立这种方法的可行性，并表征与新生儿发育和免疫成熟相关的胎龄依赖性蛋白表达模式。方法：采集东京大学附属医院新生儿重症监护病房新生儿脐带标本。分娩后立即收集长约5厘米的新鲜脐带。随后，将脐带切片成1cm的片段，在-80°C快速冷冻，保存至DIA蛋白质组学分析。对于通过DIA获得的定量蛋白质组学数据，将基因符号分配给每个蛋白质，并将表达值转化为每个样本内的z分数。为了评估四个时间点的时间变化，我们进行了时间过程分析。Jonckheere-Terpstra测试用于评估每个基因集内四个时间点的总体单调趋势。基因本体（GO）富集分析使用metscape对上述每个表达模式进行。结果：从15例新生儿脐带组织中共鉴定出6801个蛋白，这些蛋白被分为4个胎龄组：22-25周（n = 4，中位出生体重634 g（四分位间距[IQR]: 468.5-690））、26-30周（n = 4，中位出生体重1008 g (IQR: 678.5-1140.8)）、31-34周（n = 3，中位出生体重1521 g (IQR: 1389-1600)）和35-40周（n = 4，中位出生体重2477 g (IQR: 1858-2677.3)）。参与免疫应答的蛋白，尤其是介导B细胞功能的蛋白，随着胎龄的增加而显著上调，表明免疫系统逐渐成熟（22-25周vs 35-40周，p < 0.01）。相反，与mRNA加工、细胞质翻译和核糖核蛋白复合物生物发生相关的蛋白质呈相反趋势，表明极早产儿（22-25周vs 35-40周，p < 0.01）的生物合成活性升高。与器官发育相关的蛋白质标记物表现出不同的轨迹。结论：这些发现表明，脐带蛋白质组学可以作为一个强大的平台来评估出生时的功能成熟度，特别是免疫系统，并可能促进发现与新生儿护理相关的生物标志物和治疗靶点。该研究的局限性包括样本量小和使用整个脐带而不是孤立的组织区室。这项工作建立了人类脐带组织跨妊娠的第一个蛋白质组学图谱，并为早产儿管理中的分子知情策略提供了基础。
{"title":"A proteomic atlas of the human umbilical cord across gestation reveals fetal immune maturation.","authors":"Takeo Mukai, Yoshihiko Shitara, Atsushi Ito, Hiroshi Mutoh, Yoshihide Tanaka, Ryo Inuzuka, Motohiro Kato, Naoto Takahashi","doi":"10.1080/14767058.2025.2605408","DOIUrl":"https://doi.org/10.1080/14767058.2025.2605408","url":null,"abstract":"<p><strong>Introduction: </strong>Prematurity remains a leading cause of neonatal morbidity and mortality, yet the molecular mechanisms underlying functional immaturity at birth are poorly understood. To our knowledge, no study has conducted a proteomic analysis of whole umbilical cords spanning a full range of gestational ages, including infants born at the periviable gestational age (22-25 weeks). Identifying protein expression patterns that correlate with gestational maturity may offer key insights into the molecular drivers of vulnerability in preterm neonates, particularly in the domains of immune and organ development. In this study, we applied data-independent acquisition (DIA)-based mass spectrometry to profile the proteomes of umbilical cords from neonates born between 22 and 40 weeks of gestation. Our aims were to establish the feasibility of this approach and to characterize gestational age-dependent protein expression patterns with relevance to neonatal development and immune maturation.</p><p><strong>Methods: </strong>Umbilical cord samples were obtained from neonates admitted to the Neonatal Intensive Care Unit of the University of Tokyo Hospital. Fresh umbilical cord segments approximately 5 cm in length were collected immediately after delivery. Subsequently, the cords were sectioned into 1 cm fragments, snap-frozen at -80°C, and stored until DIA proteomic analysis. For quantitative proteomics data obtained by DIA, gene symbols were assigned to each protein, and the expression values were transformed into <i>z</i>-scores within each sample. To evaluate temporal changes across four time points, we performed time-course analysis. The Jonckheere-Terpstra test was used to assess the overall monotonic trend across the four time points within each gene set. Gene Ontology (GO) enrichment analysis was performed using Metascape for each expression pattern obtained above.</p><p><strong>Results: </strong>A total of 6,801 proteins were identified from umbilical cord tissues collected from 15 neonates divided into four gestational age groups: 22-25 weeks (<i>n</i> = 4, median birth weight 634 grams (interquartile range [IQR]: 468.5-690)), 26-30 weeks (<i>n</i> = 4, median birth weight 1008 g (IQR: 678.5-1140.8)), 31-34 weeks (<i>n</i> = 3, median birth weight 1521 g (IQR: 1389-1600)), and 35-40 weeks (<i>n</i> = 4, median birth weight 2477 g (IQR: 1858-2677.3)). Proteins involved in immune responses, especially those mediating B cell function, were significantly upregulated with advancing gestational age, indicating progressive immune system maturation (22-25 weeks vs 35-40 weeks, <i>p</i> < 0.01). In contrast, proteins related to mRNA processing, cytoplasmic translation, and ribonucleoprotein complex biogenesis showed inverse trends, suggesting elevated biosynthetic activity in extremely preterm neonates (22-25 weeks vs 35-40 weeks, <i>p</i> < 0.01). Protein markers associated with organ development exhibited heterogeneous trajectories.</p><p","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2605408"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-02-08DOI: 10.1080/14767058.2026.2626002
{"title":"Statement of Retraction: The effect of prophylactic oral tranexamic acid plus buccal misoprostol on blood loss after vaginal delivery: a randomized controlled trial.","authors":"","doi":"10.1080/14767058.2026.2626002","DOIUrl":"https://doi.org/10.1080/14767058.2026.2626002","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2626002"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-01-19DOI: 10.1080/14767058.2026.2614840
Ruben Quintero, K Joseph Hurt, Neeta L Vora, Neil S Seligman, Gerard P Reilly, Myra J Wick, Samuel B Wolf, Maeve Hopkins, Thomas Westover, Homa K Ahmadzia, Camille Kanaan, Andrei Rebarber, Eftichia V Kontopoulos, Jingwen Zhang, Melissa Egbert, Sophia Vourthis, Ashley Cantu-Weinstein, Jessica L Saben, Russ Jelsema, Vivienne Souter, Clark T Johnson, Peter Benn
Introduction: The importance of prenatal determination of chorionicity for the management of twin pregnancies is well recognized. However, research on the contribution of prenatal evaluation of zygosity to the management of twins is limited. We assessed the utility of adding SNP-based cell-free DNA (cfDNA) zygosity testing to ultrasound chorionicity assessment for the clinical management of twin pregnancies.
Methods: Prospective observational study involving 13 United States practices with proficiency in prenatal ultrasound. Patients diagnosed by ultrasound with twins in the first trimester were assessed with cfDNA screening for zygosity. Ultrasound assessment of chorionicity was performed prior to cfDNA results. Placental pathology was used as the gold standard for chorionicity assessment. Gestational age at delivery and standardized birthweights were compared, based on chorionicity and zygosity.
Results: 110 twin pregnancies were included. Among 79 dichorionic (DC) cases confirmed by placental pathology, one (1.3%) was misclassified as monochorionic (MC) by ultrasound, but was dizygous (DZ) by cfDNA, consistent with DC. Of 31 monozygotic (MZ) twins by cfDNA, confirmed as MC by pathology, ultrasound misclassified one (3.6%) as DC. Median gestational age at delivery was earlier for MZ twin pregnancies (35.0 weeks) compared to DZ (36.9 weeks, p = 0.02). After adjusting for fetal sex and gestational age at birth, MZDC twins had significantly lower birthweights (p = 0.006) and birthweight percentiles (p = 0.004) than DZDC twins.
Conclusions: Based on postpartum placental pathology as the reference standard for determining MC versus DC, cfDNA zygosity testing appears to aid in the prenatal assignment of chorionicity. Larger studies are needed to confirm the value of zygosity testing in the management of twin pregnancies.
{"title":"Ultrasound and SNP-based cell-free DNA zygosity testing in twin pregnancies.","authors":"Ruben Quintero, K Joseph Hurt, Neeta L Vora, Neil S Seligman, Gerard P Reilly, Myra J Wick, Samuel B Wolf, Maeve Hopkins, Thomas Westover, Homa K Ahmadzia, Camille Kanaan, Andrei Rebarber, Eftichia V Kontopoulos, Jingwen Zhang, Melissa Egbert, Sophia Vourthis, Ashley Cantu-Weinstein, Jessica L Saben, Russ Jelsema, Vivienne Souter, Clark T Johnson, Peter Benn","doi":"10.1080/14767058.2026.2614840","DOIUrl":"10.1080/14767058.2026.2614840","url":null,"abstract":"<p><strong>Introduction: </strong>The importance of prenatal determination of chorionicity for the management of twin pregnancies is well recognized. However, research on the contribution of prenatal evaluation of zygosity to the management of twins is limited. We assessed the utility of adding SNP-based cell-free DNA (cfDNA) zygosity testing to ultrasound chorionicity assessment for the clinical management of twin pregnancies.</p><p><strong>Methods: </strong>Prospective observational study involving 13 United States practices with proficiency in prenatal ultrasound. Patients diagnosed by ultrasound with twins in the first trimester were assessed with cfDNA screening for zygosity. Ultrasound assessment of chorionicity was performed prior to cfDNA results. Placental pathology was used as the gold standard for chorionicity assessment. Gestational age at delivery and standardized birthweights were compared, based on chorionicity and zygosity.</p><p><strong>Results: </strong>110 twin pregnancies were included. Among 79 dichorionic (DC) cases confirmed by placental pathology, one (1.3%) was misclassified as monochorionic (MC) by ultrasound, but was dizygous (DZ) by cfDNA, consistent with DC. Of 31 monozygotic (MZ) twins by cfDNA, confirmed as MC by pathology, ultrasound misclassified one (3.6%) as DC. Median gestational age at delivery was earlier for MZ twin pregnancies (35.0 weeks) compared to DZ (36.9 weeks, <i>p</i> = 0.02). After adjusting for fetal sex and gestational age at birth, MZDC twins had significantly lower birthweights (<i>p</i> = 0.006) and birthweight percentiles (<i>p</i> = 0.004) than DZDC twins.</p><p><strong>Conclusions: </strong>Based on postpartum placental pathology as the reference standard for determining MC versus DC, cfDNA zygosity testing appears to aid in the prenatal assignment of chorionicity. Larger studies are needed to confirm the value of zygosity testing in the management of twin pregnancies.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2614840"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-01-08DOI: 10.1080/14767058.2025.2611637
Haifeng Zong, Cuihui Li, Nan Ye, Jingyu Song, Lingling Yang, Su Fang, Jipeng Shi, Xueyu Chen, Chuanzhong Yang
Objective: To explore lung ultrasound (LUS) in the evolution of bronchopulmonary dysplasia (BPD) and the diagnostic value of LUS in BPD.
Methods: Newborn rats were randomly assigned to the room air (RA) group or the oxygen (O2) group. LUS were performed at 12 h and on the 3rd, 7th, and 10th days to explore the LUS in BPD rats. Hematoxylin-eosin staining and immunohistochemical were analyzed to evaluate pathological characteristics.
Results: LUS score (LUSs) in the O2 group was significantly increased on the 7th and 10th days. In the early stage, LUS revealed multiple B-lines and air bronchograms. In the late stage, LUS revealed anechoic echoic areas on the pleural surface and scattered dot-like hyperechoic patterns in the lung field. The LUS findings were consistent with the pathological results.
Conclusion: There was a strong positive correlation between LUS and pathological findings. LUS can be used to monitor the evolution of BPD.
{"title":"Lung ultrasound features during the evolution of BPD: a study from an animal model.","authors":"Haifeng Zong, Cuihui Li, Nan Ye, Jingyu Song, Lingling Yang, Su Fang, Jipeng Shi, Xueyu Chen, Chuanzhong Yang","doi":"10.1080/14767058.2025.2611637","DOIUrl":"https://doi.org/10.1080/14767058.2025.2611637","url":null,"abstract":"<p><strong>Objective: </strong>To explore lung ultrasound (LUS) in the evolution of bronchopulmonary dysplasia (BPD) and the diagnostic value of LUS in BPD.</p><p><strong>Methods: </strong>Newborn rats were randomly assigned to the room air (RA) group or the oxygen (O<sub>2</sub>) group. LUS were performed at 12 h and on the 3rd, 7th, and 10th days to explore the LUS in BPD rats. Hematoxylin-eosin staining and immunohistochemical were analyzed to evaluate pathological characteristics.</p><p><strong>Results: </strong>LUS score (LUSs) in the O<sub>2</sub> group was significantly increased on the 7th and 10th days. In the early stage, LUS revealed multiple B-lines and air bronchograms. In the late stage, LUS revealed anechoic echoic areas on the pleural surface and scattered dot-like hyperechoic patterns in the lung field. The LUS findings were consistent with the pathological results.</p><p><strong>Conclusion: </strong>There was a strong positive correlation between LUS and pathological findings. LUS can be used to monitor the evolution of BPD.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"39 1","pages":"2611637"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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