Pub Date : 2024-04-19DOI: 10.1097/INF.0000000000004326
M. Karyanti, C. S. Uiterwaal, Sri Rezeki Hadinegoro, I. Widyahening, Siti Rizny F Saldi, J. H. Heesterbeek, Arno W Hoes, Patricia Bruijning-Verhagen
BACKGROUND World Health Organization proposed 7 warning signs to identify the risk of severe dengue in 2009. This study aimed to evaluate the value of these warning signs in detecting severe dengue in children. MATERIAL AND METHODS A cross-sectional study was conducted utilizing data of children with clinical dengue infection obtained from medical records between January 2009 and December 2018 in Jakarta. Children with confirmed dengue were analyzed and stratified into 3 age groups: infants less than 1 year old, children 1-14 years and adolescents 15-18 years of age. Positive predictive value, negative predictive value (NPV), sensitivity and specificity of each warning sign present or absent on admission in detecting severe dengue were computed. RESULTS Six hundred ninety-nine children with clinical dengue infection were enrolled, among whom 614 (87.8%) had confirmed dengue infection, either by antigen or antibody serological tests. Severe dengue occurred in 211/614 (34.4%) cases. In infants, important warning signs on admission to detect or exclude severe dengue were liver enlargement (NPV 80.8%) and clinical fluid accumulation (NPV 75%). In children and adolescents, warning sign with highest NPV (in children 76.6% and in adolescents 91.9%) was increase in hematocrit concurrent with a rapid decrease in platelet count. Other warning signs with high NPV values in children were abdominal pain (72%), vomiting (70%), clinical fluid accumulation (69.3%), and in adolescents' abdominal pain (80.7%), vomiting (75.7%), clinical fluid accumulation (82.7%). NPVs increase with more than 1 warning sign in all age groups. CONCLUSION In infants, liver enlargement or clinical fluid accumulation are important warning signs for severe dengue, when both are absent, severe dengue is unlikely. In older children and adolescents, an increase in hematocrit with the concurrent rapid decrease in platelet count is most discriminative; followed by the absence of abdominal pain, vomiting or fluid accumulation are unlikely severe dengue.
{"title":"The Value of Warning Signs From the WHO 2009 Dengue Classification in Detecting Severe Dengue in Children.","authors":"M. Karyanti, C. S. Uiterwaal, Sri Rezeki Hadinegoro, I. Widyahening, Siti Rizny F Saldi, J. H. Heesterbeek, Arno W Hoes, Patricia Bruijning-Verhagen","doi":"10.1097/INF.0000000000004326","DOIUrl":"https://doi.org/10.1097/INF.0000000000004326","url":null,"abstract":"BACKGROUND\u0000World Health Organization proposed 7 warning signs to identify the risk of severe dengue in 2009. This study aimed to evaluate the value of these warning signs in detecting severe dengue in children.\u0000\u0000\u0000MATERIAL AND METHODS\u0000A cross-sectional study was conducted utilizing data of children with clinical dengue infection obtained from medical records between January 2009 and December 2018 in Jakarta. Children with confirmed dengue were analyzed and stratified into 3 age groups: infants less than 1 year old, children 1-14 years and adolescents 15-18 years of age. Positive predictive value, negative predictive value (NPV), sensitivity and specificity of each warning sign present or absent on admission in detecting severe dengue were computed.\u0000\u0000\u0000RESULTS\u0000Six hundred ninety-nine children with clinical dengue infection were enrolled, among whom 614 (87.8%) had confirmed dengue infection, either by antigen or antibody serological tests. Severe dengue occurred in 211/614 (34.4%) cases. In infants, important warning signs on admission to detect or exclude severe dengue were liver enlargement (NPV 80.8%) and clinical fluid accumulation (NPV 75%). In children and adolescents, warning sign with highest NPV (in children 76.6% and in adolescents 91.9%) was increase in hematocrit concurrent with a rapid decrease in platelet count. Other warning signs with high NPV values in children were abdominal pain (72%), vomiting (70%), clinical fluid accumulation (69.3%), and in adolescents' abdominal pain (80.7%), vomiting (75.7%), clinical fluid accumulation (82.7%). NPVs increase with more than 1 warning sign in all age groups.\u0000\u0000\u0000CONCLUSION\u0000In infants, liver enlargement or clinical fluid accumulation are important warning signs for severe dengue, when both are absent, severe dengue is unlikely. In older children and adolescents, an increase in hematocrit with the concurrent rapid decrease in platelet count is most discriminative; followed by the absence of abdominal pain, vomiting or fluid accumulation are unlikely severe dengue.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" 0","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neonatal sepsis poses a critical healthcare concern, as multidrug-resistant Klebsiella pneumoniae (K. pneumoniae) infections are on the rise. Understanding the antimicrobial susceptibility patterns and underlying resistance mechanism is crucial for effective treatment.
{"title":"Changing Landscape of Antimicrobial Resistance in Neonatal Sepsis: An in silico Analyses of Multidrug Resistance in Klebsiella pneumoniae.","authors":"Santhiya Vijayakumar, Hithesh Kumar, Soumya Basu, Sara Chandy, Anand Anbarasu, Anand Manoharan, Sudha Ramaiah","doi":"10.1097/inf.0000000000004358","DOIUrl":"https://doi.org/10.1097/inf.0000000000004358","url":null,"abstract":"Neonatal sepsis poses a critical healthcare concern, as multidrug-resistant Klebsiella pneumoniae (K. pneumoniae) infections are on the rise. Understanding the antimicrobial susceptibility patterns and underlying resistance mechanism is crucial for effective treatment.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.1097/inf.0000000000004361
Sandra Lynn Jaya-Bodestyne, Yee Yin Tan, Rehena Sultan, Kee Thai Yeo, Juin Yee Kong
Streptococcus gallolyticus subspecies pasteurianus (SGP), a subtype of Streptococcus bovis, is an uncommon but important cause of neonatal sepsis. Although uncommon, SGP infections during infancy have been associated with an increased risk of morbidity and mortality.
{"title":"Clinical Course and Outcomes of Infants with Streptococcus bovis/Streptococcus Gallolyticus subspecies pasteurianus Infection: A Systematic Review and Meta-analysis.","authors":"Sandra Lynn Jaya-Bodestyne, Yee Yin Tan, Rehena Sultan, Kee Thai Yeo, Juin Yee Kong","doi":"10.1097/inf.0000000000004361","DOIUrl":"https://doi.org/10.1097/inf.0000000000004361","url":null,"abstract":"Streptococcus gallolyticus subspecies pasteurianus (SGP), a subtype of Streptococcus bovis, is an uncommon but important cause of neonatal sepsis. Although uncommon, SGP infections during infancy have been associated with an increased risk of morbidity and mortality.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.1097/inf.0000000000004365
Balagangadhar R Totapally, Seevitha Totapalli, Prithvi Sendi, Paul A Martinez
The study aimed to explore the prevalence, clinical features, resource utilization, temporal trends and outcomes associated with adenoviral infections in hospitalized children.
该研究旨在探讨住院儿童腺病毒感染的发病率、临床特征、资源利用、时间趋势和相关结果。
{"title":"Epidemiology of Adenovirus Infection in Hospitalized Children in the United States From 1997 to 2019.","authors":"Balagangadhar R Totapally, Seevitha Totapalli, Prithvi Sendi, Paul A Martinez","doi":"10.1097/inf.0000000000004365","DOIUrl":"https://doi.org/10.1097/inf.0000000000004365","url":null,"abstract":"The study aimed to explore the prevalence, clinical features, resource utilization, temporal trends and outcomes associated with adenoviral infections in hospitalized children.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.1097/INF.0000000000004368
Suna Özdem, F. Öz, Zeynep Savas Şen, Ruveyda Cinni, R. Yalçınkaya, H. Çınar, Meltem Polat, G. Tanır
{"title":"Systemic Cat Scratch Disease Initially Misdiagnosed as MIS-C.","authors":"Suna Özdem, F. Öz, Zeynep Savas Şen, Ruveyda Cinni, R. Yalçınkaya, H. Çınar, Meltem Polat, G. Tanır","doi":"10.1097/INF.0000000000004368","DOIUrl":"https://doi.org/10.1097/INF.0000000000004368","url":null,"abstract":"","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"85 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140713542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1097/inf.0000000000004362
Hassen Mohammed, Christian Peut, Mark McMillan, Bing Wang, Thomas R Sullivan, Helen S Marshall
Neisseria meningitidis carriage peaks in adolescents. This secondary analysis of a randomized controlled trial (NCT03089086) assessing 4CMenB herd protection in South Australia ("B-Part-of-It" study) explored school attributes linked to baseline carriage in 34,489 adolescents prevaccination. Carriage was higher in students attending single-sex [adjusted odds ratio (aOR): 1.49; 95% confidence interval (CI): 1.14-1.93], boarding (aOR: 1.92; 1.13-3.27) and government schools (aOR: 1.32, 1.09-1.61).
{"title":"THE ROLE OF SCHOOLS IN MENINGOCOCCAL CARRIAGE AMONG ADOLESCENTS AND YOUNG ADULTS IN SOUTH AUSTRALIA.","authors":"Hassen Mohammed, Christian Peut, Mark McMillan, Bing Wang, Thomas R Sullivan, Helen S Marshall","doi":"10.1097/inf.0000000000004362","DOIUrl":"https://doi.org/10.1097/inf.0000000000004362","url":null,"abstract":"Neisseria meningitidis carriage peaks in adolescents. This secondary analysis of a randomized controlled trial (NCT03089086) assessing 4CMenB herd protection in South Australia (\"B-Part-of-It\" study) explored school attributes linked to baseline carriage in 34,489 adolescents prevaccination. Carriage was higher in students attending single-sex [adjusted odds ratio (aOR): 1.49; 95% confidence interval (CI): 1.14-1.93], boarding (aOR: 1.92; 1.13-3.27) and government schools (aOR: 1.32, 1.09-1.61).","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1097/INF.0000000000004279
Joy Verbakel, Nynke van der Gaast, R. Jaarsma
A 12-year-old boy, with no significant past medical history and no known drug allergies, presented to the emergency department with a deep laceration of his left knee after a fall on a ceramic plant pot in May 2013. A 10-cm long, L-shaped laceration heavily contaminated with soil and completely exposing the lateral femoral condyle was noted. He also was found to have a patella tendon avulsion (Fig. 1). The patient was oriented and comfortable with a blood pressure of 115/50 mm Hg, pulse of 68 beats/min and respiratory rate of 18 breaths/min. Blood tests showed the following mildly abnormal values: white cell count of 11.9 × 10 9 /L (normal: 4–11 × 10 9 /L), hemoglobin of 142 g/L (normal: 135–175 g/L), red cell
{"title":"A 12-Year-old Boy With a Knee Infection","authors":"Joy Verbakel, Nynke van der Gaast, R. Jaarsma","doi":"10.1097/INF.0000000000004279","DOIUrl":"https://doi.org/10.1097/INF.0000000000004279","url":null,"abstract":"A 12-year-old boy, with no significant past medical history and no known drug allergies, presented to the emergency department with a deep laceration of his left knee after a fall on a ceramic plant pot in May 2013. A 10-cm long, L-shaped laceration heavily contaminated with soil and completely exposing the lateral femoral condyle was noted. He also was found to have a patella tendon avulsion (Fig. 1). The patient was oriented and comfortable with a blood pressure of 115/50 mm Hg, pulse of 68 beats/min and respiratory rate of 18 breaths/min. Blood tests showed the following mildly abnormal values: white cell count of 11.9 × 10 9 /L (normal: 4–11 × 10 9 /L), hemoglobin of 142 g/L (normal: 135–175 g/L), red cell","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"1 1","pages":"483 - 486"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140716688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1097/inf.0000000000004355
Natalie Morris, Krystal Hunter, Vishwanath Bhat, Alla Kushnir
There has been a 5-fold increase in the number of cases of hepatitis C virus (HCV) infection among pregnant women, which is potentially associated with the increase in opioid use.
孕妇感染丙型肝炎病毒（HCV）的病例增加了 5 倍，这可能与阿片类药物使用的增加有关。
{"title":"Hepatitis C Exposure Diagnosis and Testing in Infants Born to Hepatitis C Virus-infected Mothers.","authors":"Natalie Morris, Krystal Hunter, Vishwanath Bhat, Alla Kushnir","doi":"10.1097/inf.0000000000004355","DOIUrl":"https://doi.org/10.1097/inf.0000000000004355","url":null,"abstract":"There has been a 5-fold increase in the number of cases of hepatitis C virus (HCV) infection among pregnant women, which is potentially associated with the increase in opioid use.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The clinical features of panniculitis caused by Pseudomonas aeruginosa, in contrast to those caused by ecthyma gangrenosum, remain unknown. Here, we report a pediatric case of P. aeruginosa panniculitis. The patient had systemic involvement without bacteremia and also had a background of autoimmune neutropenia. These features are common in ecthyma gangrenosum but have not been reported in P. aeruginosa-induced panniculitis.
{"title":"A PEDIATRIC CASE OF PANNICULITIS INDUCED BY Pseudomonas aeruginosa WITH CLINICAL FEATURES SIMILAR TO ECTHYMA GANGRENOSUM.","authors":"Urara Saito, Shogo Minamikawa, Shogo Otake, Yusuke Ishida, Mao Mizuta, Toshiaki Ishida, Shuhei Karakawa, Masashi Kasai, Yasuo Nakagishi","doi":"10.1097/inf.0000000000004363","DOIUrl":"https://doi.org/10.1097/inf.0000000000004363","url":null,"abstract":"The clinical features of panniculitis caused by Pseudomonas aeruginosa, in contrast to those caused by ecthyma gangrenosum, remain unknown. Here, we report a pediatric case of P. aeruginosa panniculitis. The patient had systemic involvement without bacteremia and also had a background of autoimmune neutropenia. These features are common in ecthyma gangrenosum but have not been reported in P. aeruginosa-induced panniculitis.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"300 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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