Pub Date : 2024-01-11DOI: 10.1097/INF.0000000000004185
Michael J. Carter, S. Shrestha, P. O’Reilly, P. Gurung, M. Gurung, S. Thorson, R. Kandasamy, M. Voysey, Elizabeth O’Mahony, Sarah Kelly, I. Ansari, Ganesh Shah, P. Amatya, Irina Tcherniaeva, Guy Berbers, David R. Murdoch, Andrew J. Pollard, S. Shrestha, Dominic F. Kelly
We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.
{"title":"Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia","authors":"Michael J. Carter, S. Shrestha, P. O’Reilly, P. Gurung, M. Gurung, S. Thorson, R. Kandasamy, M. Voysey, Elizabeth O’Mahony, Sarah Kelly, I. Ansari, Ganesh Shah, P. Amatya, Irina Tcherniaeva, Guy Berbers, David R. Murdoch, Andrew J. Pollard, S. Shrestha, Dominic F. Kelly","doi":"10.1097/INF.0000000000004185","DOIUrl":"https://doi.org/10.1097/INF.0000000000004185","url":null,"abstract":"We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"32 21","pages":"e67 - e70"},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-18DOI: 10.1097/inf.0000000000004172
Olivia Dumont, Denise Iacono, Alby Jacob, Alpna Aggarwal, Stefan H F Hagmann
A vancomycin-sparing guideline for suspected late-onset sepsis helped reduce vancomycin usage in our level-4 neonatal intensive care unit. Significant reduction in overall vancomycin use, with its likely unit-wide beneficial downstream effects, may need to be measured against the rare case of methicillin-resistant Staphylococcus aureus infection and delayed effective therapy.
{"title":"Experience With a Vancomycin-sparing Empiric Antibiotic Guideline for Late-onset Sepsis in a Level-4 Neonatal Intensive Care Unit.","authors":"Olivia Dumont, Denise Iacono, Alby Jacob, Alpna Aggarwal, Stefan H F Hagmann","doi":"10.1097/inf.0000000000004172","DOIUrl":"https://doi.org/10.1097/inf.0000000000004172","url":null,"abstract":"A vancomycin-sparing guideline for suspected late-onset sepsis helped reduce vancomycin usage in our level-4 neonatal intensive care unit. Significant reduction in overall vancomycin use, with its likely unit-wide beneficial downstream effects, may need to be measured against the rare case of methicillin-resistant Staphylococcus aureus infection and delayed effective therapy.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138745980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-14DOI: 10.1097/inf.0000000000004222
Astrid Solus, Frederic Huet, Stephanie Perez-Martin, Cindy Verney, Christelle Auvray, Christine Binquet, Lionel Piroth, Mathieu Blot
Our study aimed to compare children under 5 years hospitalized with respiratory syncytial virus in prepandemic and late-pandemic periods. We included 209 children at the Dijon University Hospital (France). We observed a nearly 3-fold increase in the number of cases in the late period, with older children, but less frequently requiring intensive care. These observations could help prepare a new pandemic.
{"title":"CHILDREN HOSPITALIZED WITH RESPIRATORY SYNCYTIAL VIRUS INFECTION: A PRE VERSUS LATE COVID-19 PANDEMIC COMPARISON.","authors":"Astrid Solus, Frederic Huet, Stephanie Perez-Martin, Cindy Verney, Christelle Auvray, Christine Binquet, Lionel Piroth, Mathieu Blot","doi":"10.1097/inf.0000000000004222","DOIUrl":"https://doi.org/10.1097/inf.0000000000004222","url":null,"abstract":"Our study aimed to compare children under 5 years hospitalized with respiratory syncytial virus in prepandemic and late-pandemic periods. We included 209 children at the Dijon University Hospital (France). We observed a nearly 3-fold increase in the number of cases in the late period, with older children, but less frequently requiring intensive care. These observations could help prepare a new pandemic.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138687863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-14DOI: 10.1097/inf.0000000000004218
Jou Wei, Conrad Brown, Tomas Moore, Nicolette Graham, Mathew Davis, Simon Gatehouse, Clare Nourse
Postoperative spinal implant infection following pediatric spinal surgery often presents a management dilemma. We aimed to characterize our experience in this cohort of patients, hoping to provide further insight when approaching these challenging cases.
{"title":"Implant-associated Infection After Pediatric Spine Deformity Surgery: Is Removal of Hardware Indicated?","authors":"Jou Wei, Conrad Brown, Tomas Moore, Nicolette Graham, Mathew Davis, Simon Gatehouse, Clare Nourse","doi":"10.1097/inf.0000000000004218","DOIUrl":"https://doi.org/10.1097/inf.0000000000004218","url":null,"abstract":"Postoperative spinal implant infection following pediatric spinal surgery often presents a management dilemma. We aimed to characterize our experience in this cohort of patients, hoping to provide further insight when approaching these challenging cases.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138687870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-14DOI: 10.1097/inf.0000000000004217
Ashwin Ramanathan, Weihao Lee, Joseph Peplinski, Ariel O Mace, David A Foley
We compared the epidemiology, severity and management of hospitalized respiratory syncytial virus (n = 305) and human metapneumovirus (n = 39) bronchiolitis in a setting with high respiratory virus testing (95% of admissions tested). Respiratory syncytial virus-positive infants were younger and tended to require more hydration support and longer hospital stays compared to human metapneumovirus-positive infants. Respiratory support requirements were similar between groups despite significant age differences.
{"title":"HEAD-TO-HEAD COMPARISON BETWEEN RESPIRATORY SYNCYTIAL VIRUS AND HUMAN METAPNEUMOVIRUS BRONCHIOLITIS IN THE SETTING OF INCREASED VIRAL TESTING.","authors":"Ashwin Ramanathan, Weihao Lee, Joseph Peplinski, Ariel O Mace, David A Foley","doi":"10.1097/inf.0000000000004217","DOIUrl":"https://doi.org/10.1097/inf.0000000000004217","url":null,"abstract":"We compared the epidemiology, severity and management of hospitalized respiratory syncytial virus (n = 305) and human metapneumovirus (n = 39) bronchiolitis in a setting with high respiratory virus testing (95% of admissions tested). Respiratory syncytial virus-positive infants were younger and tended to require more hydration support and longer hospital stays compared to human metapneumovirus-positive infants. Respiratory support requirements were similar between groups despite significant age differences.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"11 9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138687920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13DOI: 10.1097/inf.0000000000004212
Catherine R Murphy, Zheyi Teoh, Daniel Whitehurst, Caitlin Brammer, Kerrigan Perkins, Grant Paulsen, Hilary Miller-Handley, Lara Danziger-Isakov, William R Otto
Treatment of candidemia may be complicated by hematogenous dissemination. Limited data exist to guide decision-making regarding the evaluation for disseminated disease. We sought to describe the epidemiology of invasive disease after candidemia, report the diagnostic evaluations performed and identify risk factors for disseminated disease.
{"title":"Disseminated Disease After Candidemia in Children and Young Adults: Epidemiology, Diagnostic Evaluation and Risk Factors.","authors":"Catherine R Murphy, Zheyi Teoh, Daniel Whitehurst, Caitlin Brammer, Kerrigan Perkins, Grant Paulsen, Hilary Miller-Handley, Lara Danziger-Isakov, William R Otto","doi":"10.1097/inf.0000000000004212","DOIUrl":"https://doi.org/10.1097/inf.0000000000004212","url":null,"abstract":"Treatment of candidemia may be complicated by hematogenous dissemination. Limited data exist to guide decision-making regarding the evaluation for disseminated disease. We sought to describe the epidemiology of invasive disease after candidemia, report the diagnostic evaluations performed and identify risk factors for disseminated disease.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138687860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute necrotizing encephalopathy (ANE) is a rare childhood neurological disorder. The familiar type of ANE (ANE1) is associated with a mutation in the RANBP2 gene. Both SARS-CoV-2 and RANBP2 mutations are responsible for the manifestation of a hyper-inflammatory response that invades the central nervous system and plays a key role in the rapid progression of encephalopathy.
{"title":"A Rare Case of COVID-19 Related Acute Necrotizing Encephalopathy With the RANBP2 Mutation in a Pediatric Patient.","authors":"Evangelos Christou, Alkisti Kotsia, Konstantinos Tziouvas, Panagiotis Filias, Aristoula Patsoura","doi":"10.1097/inf.0000000000004215","DOIUrl":"https://doi.org/10.1097/inf.0000000000004215","url":null,"abstract":"Acute necrotizing encephalopathy (ANE) is a rare childhood neurological disorder. The familiar type of ANE (ANE1) is associated with a mutation in the RANBP2 gene. Both SARS-CoV-2 and RANBP2 mutations are responsible for the manifestation of a hyper-inflammatory response that invades the central nervous system and plays a key role in the rapid progression of encephalopathy.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138687635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1097/inf.0000000000004203
Pelayo Leon-Jimenez, Maria Lorenzo-Martin, Cristiana Tomatis-Souverbielle, Shoghik Akoghlanian, Linda Cripe, Octavio Ramilo, Asuncion Mejias
We present a rare case of pan-valvular involvement in a 5-month-old female with Kawasaki disease shock syndrome despite early treatment with intravenous immunoglobulin and corticosteroids. She experienced a favorable outcome after the addition of infliximab, which was guided based on clinical, laboratory and echocardiogram findings, rather than recrudescence of fever, the most common indicator of intravenous immunoglobulin resistance.
{"title":"Pan-valvulitis in Children with Kawasaki Disease: A Case Report and Review of the Literature.","authors":"Pelayo Leon-Jimenez, Maria Lorenzo-Martin, Cristiana Tomatis-Souverbielle, Shoghik Akoghlanian, Linda Cripe, Octavio Ramilo, Asuncion Mejias","doi":"10.1097/inf.0000000000004203","DOIUrl":"https://doi.org/10.1097/inf.0000000000004203","url":null,"abstract":"We present a rare case of pan-valvular involvement in a 5-month-old female with Kawasaki disease shock syndrome despite early treatment with intravenous immunoglobulin and corticosteroids. She experienced a favorable outcome after the addition of infliximab, which was guided based on clinical, laboratory and echocardiogram findings, rather than recrudescence of fever, the most common indicator of intravenous immunoglobulin resistance.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1097/inf.0000000000004209
Lael Mode, Judith A Guzman-Cottrill, Mikelle Bassett
Cephalosporins are frequently used to treat pediatric infections and are overall well tolerated. Cefepime, a fourth-generation cephalosporin, has an excellent safety profile in pediatrics. We report a rare case of cefepime-induced acute liver injury in a pediatric patient, which resolved after antibiotic discontinuation.
{"title":"Cefepime-induced Acute Liver Injury in a 5-Year-old Boy.","authors":"Lael Mode, Judith A Guzman-Cottrill, Mikelle Bassett","doi":"10.1097/inf.0000000000004209","DOIUrl":"https://doi.org/10.1097/inf.0000000000004209","url":null,"abstract":"Cephalosporins are frequently used to treat pediatric infections and are overall well tolerated. Cefepime, a fourth-generation cephalosporin, has an excellent safety profile in pediatrics. We report a rare case of cefepime-induced acute liver injury in a pediatric patient, which resolved after antibiotic discontinuation.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"168 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-06DOI: 10.1097/inf.0000000000004176
María Ríos-Barnés, Eneritz Velasco-Arnaiz, Clàudia Fortuny, Marta Benavides, Fernando Baquero-Artigao, Oihana Muga, Rut Del Valle, Marie Antoinette Frick, Xavier Bringué, Susana Herrero, Javier Vilas, Almudena Alonso-Ojembarrena, Laura Castells-Vilella, Pablo Rojo, Daniel Blázquez-Gamero, Cristina Esteva, Emilia Sánchez, Ana Alarcón, Antoni Noguera-Julian
We aimed to determine the prevalence and severity of glomerular and tubular renal dysfunction by means of urinalysis in infants and toddlers with congenital cytomegalovirus infection (cCMV) and their association with cCMV disease, viruria and antiviral treatment.
{"title":"Renal Function Impairment in Children With Congenital Cytomegalovirus Infection: A Cross-sectional Study.","authors":"María Ríos-Barnés, Eneritz Velasco-Arnaiz, Clàudia Fortuny, Marta Benavides, Fernando Baquero-Artigao, Oihana Muga, Rut Del Valle, Marie Antoinette Frick, Xavier Bringué, Susana Herrero, Javier Vilas, Almudena Alonso-Ojembarrena, Laura Castells-Vilella, Pablo Rojo, Daniel Blázquez-Gamero, Cristina Esteva, Emilia Sánchez, Ana Alarcón, Antoni Noguera-Julian","doi":"10.1097/inf.0000000000004176","DOIUrl":"https://doi.org/10.1097/inf.0000000000004176","url":null,"abstract":"We aimed to determine the prevalence and severity of glomerular and tubular renal dysfunction by means of urinalysis in infants and toddlers with congenital cytomegalovirus infection (cCMV) and their association with cCMV disease, viruria and antiviral treatment.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"53 79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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