Pub Date : 2024-04-15DOI: 10.3899/jrheum.2023-1217
Stylianos Georgiadis, Lykke Midtbøll Ørnbjerg, Brigitte Michelsen, Tore K Kvien, Daniela Di Giuseppe, Johan K Wallman, Jakub Závada, Sella A Provan, Eirik Klami Kristianslund, Ana Maria Rodrigues, Maria José Santos, Žiga Rotar, Katja Perdan Pirkmajer, Dan Nordström, Gary J Macfarlane, Gareth T Jones, Irene van der Horst-Bruinsma, Pasoon Hellamand, Mikkel Østergaard, Merete Lund Hetland
Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) is recommended over erythrocyte sedimentation rate (ASDAS-ESR) to assess disease activity in axial spondyloarthritis (axSpA). Although ASDAS-CRP and ASDAS-ESR are not interchangeable, the same disease activity cut-offs are used for both. We aimed to estimate optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-offs (1.3, 2.1 and 3.5) and investigate the potential improvement of level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states when applying these estimated cut-offs.
{"title":"ASDAS-CRP and ASDAS-ESR cut-offs for disease activity states in axial spondyloarthritis - Are they interchangeable?","authors":"Stylianos Georgiadis, Lykke Midtbøll Ørnbjerg, Brigitte Michelsen, Tore K Kvien, Daniela Di Giuseppe, Johan K Wallman, Jakub Závada, Sella A Provan, Eirik Klami Kristianslund, Ana Maria Rodrigues, Maria José Santos, Žiga Rotar, Katja Perdan Pirkmajer, Dan Nordström, Gary J Macfarlane, Gareth T Jones, Irene van der Horst-Bruinsma, Pasoon Hellamand, Mikkel Østergaard, Merete Lund Hetland","doi":"10.3899/jrheum.2023-1217","DOIUrl":"https://doi.org/10.3899/jrheum.2023-1217","url":null,"abstract":"Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) is recommended over erythrocyte sedimentation rate (ASDAS-ESR) to assess disease activity in axial spondyloarthritis (axSpA). Although ASDAS-CRP and ASDAS-ESR are not interchangeable, the same disease activity cut-offs are used for both. We aimed to estimate optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-offs (1.3, 2.1 and 3.5) and investigate the potential improvement of level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states when applying these estimated cut-offs.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"212 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140556841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2023-0891
Shakeel Subdar, Kiran Dhiman, Nicole M S Hartfeld, Alison M Hoens, Krista White, Sarah L Manske, Glen Hazlewood, Diane Lacaille, Elena Lopatina, Megan R W Barber, Dianne Mosher, Aurore Fifi-Mah, Marinka Twilt, Nadia Luca, Karen L Then, Trafford Crump, Saania Zafar, Kelly Osinski, Claire E H Barber
Patient-initiated follow-up (PIFU) for rheumatoid arthritis (RA) is a model of care delivery wherein patients contact the clinic when needed instead of regularly scheduled followups. Our objective was to investigate the influence of different patient eligibility characteristics on the number of potentially deferred visits to inform future implementation of a PIFU strategy.
{"title":"Investigating the influence of patient eligibility characteristics on the number of deferrable rheumatologist visits: planning for a patient-initiated follow-up (PIFU) strategy.","authors":"Shakeel Subdar, Kiran Dhiman, Nicole M S Hartfeld, Alison M Hoens, Krista White, Sarah L Manske, Glen Hazlewood, Diane Lacaille, Elena Lopatina, Megan R W Barber, Dianne Mosher, Aurore Fifi-Mah, Marinka Twilt, Nadia Luca, Karen L Then, Trafford Crump, Saania Zafar, Kelly Osinski, Claire E H Barber","doi":"10.3899/jrheum.2023-0891","DOIUrl":"https://doi.org/10.3899/jrheum.2023-0891","url":null,"abstract":"Patient-initiated follow-up (PIFU) for rheumatoid arthritis (RA) is a model of care delivery wherein patients contact the clinic when needed instead of regularly scheduled followups. Our objective was to investigate the influence of different patient eligibility characteristics on the number of potentially deferred visits to inform future implementation of a PIFU strategy.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139659840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2023-0788
Tessalyn Morrison, Moriah Gottman, Toan Do, James T Rosenbaum, Daniela Ghetie, Marcia Friedman
Scleritis may be idiopathic or caused by trauma, infections, or an immune-mediated condition. Our study aimed to understand the relationship between scleritis and immune-mediated disease, including presenting characteristics, serologies, and treatment course. Understanding these associations may allow clinicians to risk-stratify patients and predict their clinical and treatment course.
{"title":"Scleritis and development of immune-mediated disease: A retrospective chart review.","authors":"Tessalyn Morrison, Moriah Gottman, Toan Do, James T Rosenbaum, Daniela Ghetie, Marcia Friedman","doi":"10.3899/jrheum.2023-0788","DOIUrl":"https://doi.org/10.3899/jrheum.2023-0788","url":null,"abstract":"Scleritis may be idiopathic or caused by trauma, infections, or an immune-mediated condition. Our study aimed to understand the relationship between scleritis and immune-mediated disease, including presenting characteristics, serologies, and treatment course. Understanding these associations may allow clinicians to risk-stratify patients and predict their clinical and treatment course.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139659921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2023-0588
Anna Wierczeiko, Matthias Linke, Johannes Peter Friedrich, Jan Koch, Andreas Schwarting, Andreas Krause, Susanne Gerber, Alexander Gerber
Rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) is one of the most common and prognostic organ manifestations of RA. Therefore, to allow effective treatment, it is of crucial importance to diagnose RA-ILD at the earliest possible stage. So far, the gold standard of early detection has been high-resolution computed tomography (HRCT) of the lungs. This procedure involves considerable radiation exposure for the patient and is therefore unsuitable as a routine screening measure for ethical reasons. Here, we propose the analysis of characteristic gene expression patterns as a biomarker to aid in the early detection and initiation of appropriate, possibly antifibrotic, therapy.
{"title":"A Call for Gene Expression Analysis in Whole Blood of Patients With Rheumatoid Arthritis (RA) as a Biomarker for RA-Associated Interstitial Lung Disease.","authors":"Anna Wierczeiko, Matthias Linke, Johannes Peter Friedrich, Jan Koch, Andreas Schwarting, Andreas Krause, Susanne Gerber, Alexander Gerber","doi":"10.3899/jrheum.2023-0588","DOIUrl":"https://doi.org/10.3899/jrheum.2023-0588","url":null,"abstract":"Rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) is one of the most common and prognostic organ manifestations of RA. Therefore, to allow effective treatment, it is of crucial importance to diagnose RA-ILD at the earliest possible stage. So far, the gold standard of early detection has been high-resolution computed tomography (HRCT) of the lungs. This procedure involves considerable radiation exposure for the patient and is therefore unsuitable as a routine screening measure for ethical reasons. Here, we propose the analysis of characteristic gene expression patterns as a biomarker to aid in the early detection and initiation of appropriate, possibly antifibrotic, therapy.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139659828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2023-0907
Salome Kristensen, Amalie Made Hagelskjær, René Cordtz, Sofie Bliddal, Anders Sandermann Mortensen, Claus Henrik Nielsen, Ulla Feldt-Rasmussen, Karen Buch Lauridsen, Lene Dreyer
This study aimed to compare the prevalence and incidence of polyautoimmunity between anticyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative patients with rheumatoid arthritis (RA).
{"title":"Polyautoimmunity in patients with anti-cyclic citrullinated peptide antibody-positive and -negative rheumatoid arthritis: a nationwide cohort study from Denmark.","authors":"Salome Kristensen, Amalie Made Hagelskjær, René Cordtz, Sofie Bliddal, Anders Sandermann Mortensen, Claus Henrik Nielsen, Ulla Feldt-Rasmussen, Karen Buch Lauridsen, Lene Dreyer","doi":"10.3899/jrheum.2023-0907","DOIUrl":"https://doi.org/10.3899/jrheum.2023-0907","url":null,"abstract":"This study aimed to compare the prevalence and incidence of polyautoimmunity between anticyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative patients with rheumatoid arthritis (RA).","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139659989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2023-0415
Cosimo Bruni, Lorenzo Tofani, Alexandru Garaiman, Suzana Jordan, Carmen-Marina Mihai, Rucsandra Dobrota, Muriel Elhai, Mike Oliver Becker, Anna-Maria Hoffmann-Vold, Thomas Frauenfelder, Marco Matucci-Cerinic, Oliver Distler
Mean lung attenuation, skewness, and kurtosis are histogram-based densitometry variables that quantify systemic sclerosis-associated interstitial lung disease (SSc-ILD) and were recently merged into a computerized integrated index (CII). Our work tested the CII in low-dose 9-slice (reduced) and standard high-resolution computed tomography (CT) scans to evaluate extensive SSc-ILD and predict mortality.
{"title":"Histogram-Based Densitometry Index to Assess the Severity of Interstitial Lung Disease in Systemic Sclerosis in Standard and Low-Dose Computed Tomography.","authors":"Cosimo Bruni, Lorenzo Tofani, Alexandru Garaiman, Suzana Jordan, Carmen-Marina Mihai, Rucsandra Dobrota, Muriel Elhai, Mike Oliver Becker, Anna-Maria Hoffmann-Vold, Thomas Frauenfelder, Marco Matucci-Cerinic, Oliver Distler","doi":"10.3899/jrheum.2023-0415","DOIUrl":"https://doi.org/10.3899/jrheum.2023-0415","url":null,"abstract":"Mean lung attenuation, skewness, and kurtosis are histogram-based densitometry variables that quantify systemic sclerosis-associated interstitial lung disease (SSc-ILD) and were recently merged into a computerized integrated index (CII). Our work tested the CII in low-dose 9-slice (reduced) and standard high-resolution computed tomography (CT) scans to evaluate extensive SSc-ILD and predict mortality.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2023-0867
Victoria Furer, Clara Weil, Gabriel Chodik, Shera Ann Slav, Shiran Naftelberg Blonder, Yonit Fisher-Shoval, Moran Barak, Ori Elkayam
Vaccination against preventable infections is important for rheumatic diseases management. This study assessed the vaccination coverage and predictors among patients with rheumatic diseases using real-world data from Israel.
{"title":"Real-world coverage with influenza, pneumococcal and herpes zoster vaccines among patients with rheumatic diseases in a nationwide health care plan.","authors":"Victoria Furer, Clara Weil, Gabriel Chodik, Shera Ann Slav, Shiran Naftelberg Blonder, Yonit Fisher-Shoval, Moran Barak, Ori Elkayam","doi":"10.3899/jrheum.2023-0867","DOIUrl":"https://doi.org/10.3899/jrheum.2023-0867","url":null,"abstract":"Vaccination against preventable infections is important for rheumatic diseases management. This study assessed the vaccination coverage and predictors among patients with rheumatic diseases using real-world data from Israel.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2023-1210
Miguel Á González-Gay, Santos Castañeda, Iván Ferraz-Amaro
The term metabolic syndrome (MetS) encompasses a cluster of risk factors such as central obesity, high blood pressure, impaired fasting glucose, high triglycerides, and low high-density lipoprotein cholesterol (HDL-C), all of which are specific to cardiovascular (CV) disease.1 MetS is frequently observed in patients with rheumatoid arthritis (RA).2,3 In this regard, MetS abnormalities increase the risk of CV disease in these patients.4,5.
{"title":"Metabolic Syndrome: A Predisposing Factor for Rheumatoid Arthritis.","authors":"Miguel Á González-Gay, Santos Castañeda, Iván Ferraz-Amaro","doi":"10.3899/jrheum.2023-1210","DOIUrl":"https://doi.org/10.3899/jrheum.2023-1210","url":null,"abstract":"The term <i>metabolic syndrome</i> (<i>MetS</i>) encompasses a cluster of risk factors such as central obesity, high blood pressure, impaired fasting glucose, high triglycerides, and low high-density lipoprotein cholesterol (HDL-C), all of which are specific to cardiovascular (CV) disease.<sup>1</sup> MetS is frequently observed in patients with rheumatoid arthritis (RA).<sup>2,3</sup> In this regard, MetS abnormalities increase the risk of CV disease in these patients.<sup>4,5</sup>.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2024-0006
Alfred H J Kim
Vaccination remains the most important intervention to attenuate the risk and severity of infectious diseases in those immunosuppressed for the treatment of rheumatic conditions and is indeed true for coronavirus disease 2019 (COVID-19). Substantial reductions in the hazard ratios (HRs) of breakthrough infections were observed in those with immune-mediated inflammatory diseases (IMIDs) vaccinated with the initial series (HR 0.143) and after the third dose (HR 0.017) of BNT162b2 compared to unvaccinated patients.1.
{"title":"Additional Reassuring Data for SARS-CoV-2 Vaccination in Immune-Mediated Inflammatory Diseases, but With a Catch.","authors":"Alfred H J Kim","doi":"10.3899/jrheum.2024-0006","DOIUrl":"https://doi.org/10.3899/jrheum.2024-0006","url":null,"abstract":"Vaccination remains the most important intervention to attenuate the risk and severity of infectious diseases in those immunosuppressed for the treatment of rheumatic conditions and is indeed true for coronavirus disease 2019 (COVID-19). Substantial reductions in the hazard ratios (HRs) of breakthrough infections were observed in those with immune-mediated inflammatory diseases (IMIDs) vaccinated with the initial series (HR 0.143) and after the third dose (HR 0.017) of BNT162b2 compared to unvaccinated patients.<sup>1</sup>.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"164 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.3899/jrheum.2023-1044
Johannes Nossent, Helen Keen, David Preen, Charles Inderjeeth
To compare cancer incidence, type and survival between patients with idiopathic inflammatory myopathies (IIMs) in Western Australia (WA) and the general population.
目的：比较西澳大利亚（WA）特发性炎症性肌病（IIMs）患者和普通人群的癌症发病率、类型和存活率。
{"title":"Cancer risk and mortality in hospitalised patients with idiopathic inflammatory myopathies in Western Australia.","authors":"Johannes Nossent, Helen Keen, David Preen, Charles Inderjeeth","doi":"10.3899/jrheum.2023-1044","DOIUrl":"https://doi.org/10.3899/jrheum.2023-1044","url":null,"abstract":"To compare cancer incidence, type and survival between patients with idiopathic inflammatory myopathies (IIMs) in Western Australia (WA) and the general population.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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