Pub Date : 2025-11-15DOI: 10.3899/jrheum.2025-0776
Dana Y L Lee,Sharmayne R E Brady,Tai-Juan Aw
{"title":"An Uncommon Case of Cerebellar Leukoencephalopathy Secondary to Low-Dose Methotrexate.","authors":"Dana Y L Lee,Sharmayne R E Brady,Tai-Juan Aw","doi":"10.3899/jrheum.2025-0776","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0776","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-15DOI: 10.3899/jrheum.2025-0465
Heta Patel,Sarah Stoots,Joan Von Feldt,Joshua F Baker
OBJECTIVEWe aimed to evaluate the performance of cardiovascular risk prediction tools in identifying Systemic Lupus Erythematosus (SLE) patients with coronary artery calcification (CAC).METHODSWe conducted a post-hoc analysis of a prior case-control study of adult, female patients with SLE and matched controls. We excluded patients who already met cardiology guidelines for recommended statin use. We risk stratified patients per Atherosclerotic Cardiovascular Disease (ASCVD) and SLE-specific risk (SLECRISK) criteria and determined rates of abnormal CAC. We used two-sample t-tests, two-sample Wilcoxon rank-sum (Mann-Whitney) tests, and Chi-squared tests to compare various characteristics between subgroups and used logistic regression to assess adjusted risk for SLE patients compared to controls.RESULTSWe analyzed 128 patients with SLE and 138 controls. Rates of abnormal CAC between the SLE and control groups were 31.3% (40/128) and 12.3% (17/138) with similar mean ASCVD risk scores (2.2% vs. 1.9%). Both the ASCVD and SLECRISK scores had relatively high specificity (95-100%) for abnormal CAC. The ASCVD score demonstrated poor sensitivity in both control (17.6%) and SLE (15.0%) groups with sensitivity doubling to 30.8% among SLE patients with the use of the SLECRISK score. Among lupus participants who were low ASCVD risk, those with abnormal CAC were more likely to be older and have lower GFR, longer disease duration, higher insulin resistance, and higher LDL and cholesterol levels.CONCLUSIONThe poor performance of conventional and even modified risk scores suggest a continued need for screening approaches, including CAC, to determine cardiovascular disease risk in the lupus patient population.
{"title":"Performance of Risk Score Calculators in the Identification of Coronary Artery Calcification in Patients with Systemic Lupus Erythematosus.","authors":"Heta Patel,Sarah Stoots,Joan Von Feldt,Joshua F Baker","doi":"10.3899/jrheum.2025-0465","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0465","url":null,"abstract":"OBJECTIVEWe aimed to evaluate the performance of cardiovascular risk prediction tools in identifying Systemic Lupus Erythematosus (SLE) patients with coronary artery calcification (CAC).METHODSWe conducted a post-hoc analysis of a prior case-control study of adult, female patients with SLE and matched controls. We excluded patients who already met cardiology guidelines for recommended statin use. We risk stratified patients per Atherosclerotic Cardiovascular Disease (ASCVD) and SLE-specific risk (SLECRISK) criteria and determined rates of abnormal CAC. We used two-sample t-tests, two-sample Wilcoxon rank-sum (Mann-Whitney) tests, and Chi-squared tests to compare various characteristics between subgroups and used logistic regression to assess adjusted risk for SLE patients compared to controls.RESULTSWe analyzed 128 patients with SLE and 138 controls. Rates of abnormal CAC between the SLE and control groups were 31.3% (40/128) and 12.3% (17/138) with similar mean ASCVD risk scores (2.2% vs. 1.9%). Both the ASCVD and SLECRISK scores had relatively high specificity (95-100%) for abnormal CAC. The ASCVD score demonstrated poor sensitivity in both control (17.6%) and SLE (15.0%) groups with sensitivity doubling to 30.8% among SLE patients with the use of the SLECRISK score. Among lupus participants who were low ASCVD risk, those with abnormal CAC were more likely to be older and have lower GFR, longer disease duration, higher insulin resistance, and higher LDL and cholesterol levels.CONCLUSIONThe poor performance of conventional and even modified risk scores suggest a continued need for screening approaches, including CAC, to determine cardiovascular disease risk in the lupus patient population.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-15DOI: 10.3899/jrheum.2025-0684
Wen Qi,Sai Yan Yuen,Mihaela Luminita Popescu,Roger Yang,Charles-Edouard Giguère
OBJECTIVEThe objective of this scoping review was to summarize the current literature on the burden of inflammatory arthritis, tenosynovitis, and enthesitis detected on musculoskeletal ultrasound (MSUS) in adult systemic lupus erythematosus (SLE) patients.METHODSSystematic literature search was performed using Pubmed, Embase and Cochrane Library between January 1st 2015 and February 1st 2025, according to the PRISMA extension for scoping reviews. To be included, studies on the adult SLE population must have reported on either synovitis, tenosynovitis or enthesitis. Exclusion criteria were pediatric studies, rhupus-only studies, case series with less than 5 patients, review articles and conference abstracts. A pre-established standardized data collection sheet was used.RESULTSThe literature search found 24 articles that met inclusion criteria. Studies reported on inflammatory arthritis (n= 20), tenosynovitis (n = 16), and enthesitis (n = 7). Most studies were cross sectional (n = 20/24). Using criteria that were discriminatory for inflammatory enthesitis (power doppler and bone erosion), inflammatory enthesitis was found in SLE patients, and they were more common at the distal patellar, proximal patellar and quadriceps enthesis. In the general SLE population, studies on inflammatory arthritis and tenosynovitis found clinical arthritis in 18-38% of patients, MSUS arthritis in 33-55% of patients, subclinical MSUS arthritis in 9-21% of patients and tenosynovitis in 8-38% of patients. MSUS findings correlated with SLE disease activity indices, such as SLEDAI and BILAG.CONCLUSIONEnthesitis may be a new musculoskeletal domain in SLE. MSUS can be useful in diagnosing tenosynovitis and subclinical inflammatory arthritis in SLE patients.
{"title":"The Burden of Enthesitis, Inflammatory Arthritis and Tenosynovitis on Musculoskeletal Ultrasound in Systemic Lupus Erythematous: A Scoping Review.","authors":"Wen Qi,Sai Yan Yuen,Mihaela Luminita Popescu,Roger Yang,Charles-Edouard Giguère","doi":"10.3899/jrheum.2025-0684","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0684","url":null,"abstract":"OBJECTIVEThe objective of this scoping review was to summarize the current literature on the burden of inflammatory arthritis, tenosynovitis, and enthesitis detected on musculoskeletal ultrasound (MSUS) in adult systemic lupus erythematosus (SLE) patients.METHODSSystematic literature search was performed using Pubmed, Embase and Cochrane Library between January 1st 2015 and February 1st 2025, according to the PRISMA extension for scoping reviews. To be included, studies on the adult SLE population must have reported on either synovitis, tenosynovitis or enthesitis. Exclusion criteria were pediatric studies, rhupus-only studies, case series with less than 5 patients, review articles and conference abstracts. A pre-established standardized data collection sheet was used.RESULTSThe literature search found 24 articles that met inclusion criteria. Studies reported on inflammatory arthritis (n= 20), tenosynovitis (n = 16), and enthesitis (n = 7). Most studies were cross sectional (n = 20/24). Using criteria that were discriminatory for inflammatory enthesitis (power doppler and bone erosion), inflammatory enthesitis was found in SLE patients, and they were more common at the distal patellar, proximal patellar and quadriceps enthesis. In the general SLE population, studies on inflammatory arthritis and tenosynovitis found clinical arthritis in 18-38% of patients, MSUS arthritis in 33-55% of patients, subclinical MSUS arthritis in 9-21% of patients and tenosynovitis in 8-38% of patients. MSUS findings correlated with SLE disease activity indices, such as SLEDAI and BILAG.CONCLUSIONEnthesitis may be a new musculoskeletal domain in SLE. MSUS can be useful in diagnosing tenosynovitis and subclinical inflammatory arthritis in SLE patients.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.3899/jrheum.2025-1016
Avira Som,Naomi J Patel
{"title":"Ongoing Benefits of SARS-CoV-2 Vaccination and Booster Vaccination 5 Years Following the Start of the COVID-19 Pandemic.","authors":"Avira Som,Naomi J Patel","doi":"10.3899/jrheum.2025-1016","DOIUrl":"https://doi.org/10.3899/jrheum.2025-1016","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.3899/jrheum.2025-1004
Simon J Bowman,Benjamin A Fisher
{"title":"Sjögren Disease: Does an Accurate Diagnosis Matter?","authors":"Simon J Bowman,Benjamin A Fisher","doi":"10.3899/jrheum.2025-1004","DOIUrl":"https://doi.org/10.3899/jrheum.2025-1004","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.3899/jrheum.2025-0903
Daiki Nakagomi,Shunichiro Hanai
{"title":"Bone Erosion Repair With a Janus Kinase Inhibitor.","authors":"Daiki Nakagomi,Shunichiro Hanai","doi":"10.3899/jrheum.2025-0903","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0903","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"128 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of Successive Thrombophlebitis and Takayasu Arteritis Associated With Crohn Disease in a Pediatric Patient: A Case Report.","authors":"Sadanobu Yamaguchi,Masaru Kawamura,Rie Shirayama,Takayuki Hoshina","doi":"10.3899/jrheum.2025-0520","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0520","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.3899/jrheum.2025-0126
Ning Zhuo
{"title":"PPI Use and Its Significant Association With an Increased Incidence of Intestinal Behçet Disease.","authors":"Ning Zhuo","doi":"10.3899/jrheum.2025-0126","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0126","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.3899/jrheum.2025-0598
Ya-Ning Chan,Kaveh Ardalan,Li Lin,Dandan Chen,Elissa R Weitzman,Fatma Dedeoglu,Richard K Vehe,Emily von Scheven,Yukiko Kimura,Laura E Schanberg,Bryce B Reeve,
OBJECTIVEExplore congruence between child self-reported and caregiver-proxy reported health-related quality of life (HRQOL) over time in juvenile idiopathic arthritis (JIA) and childhood-onset systemic lupus erythematosus (cSLE) and identify factors associated with the level of congruence.METHODSData were from an observational, longitudinal cohort study conducted to validate the Patient- Reported Outcomes Measurement Information System® (PROMIS®) measures. HRQOL was assessed at baseline, 6 months, and 12 months. Four hundred fifty-one children (8-17 years) diagnosed with JIA or cSLE and their caregivers completed the PROMIS Pediatric Self-Report and Parent-Proxy measures, respectively. A one-way random-effects model was used to estimate the intraclass correlation coefficient (ICC) for congruence between child and caregiver reports, and multivariable mixed-effect models were used to identify associated demographic and clinical factors.RESULTSThe study cohort (87.1% JIA) had a mean age of 13.8 years and were 71.4% female. Across all HRQOL domains, child self-reported and caregiver-proxy reported mobility, physical activity, fatigue, pain interference, depressive symptoms, and psychological stress had moderate associations (ICC= 0.50-0.68), while child self-reported and caregiver-proxy-reported family relationships and anxiety were weakly associated (ICC= 0.34-0.42). Older children had higher congruence with their caregivers on symptom domains (0.25-0.75 points) than younger children; female children had higher congruence with their caregivers on psychological symptoms (-2.02 to -1.98 points) than male children.CONCLUSIONCaregivers provide complementary information on the physical aspects of HRQOL with a tendency to estimate worse symptoms and decreased functioning. Child self-report remains the gold standard for understanding HRQOL in pediatric populations with rheumatic diseases.
{"title":"Congruence Between Child Self-Reported and Caregiver-Proxy Health-Related Quality of Life in Children with Juvenile Idiopathic Arthritis and Systemic Lupus Erythematosus.","authors":"Ya-Ning Chan,Kaveh Ardalan,Li Lin,Dandan Chen,Elissa R Weitzman,Fatma Dedeoglu,Richard K Vehe,Emily von Scheven,Yukiko Kimura,Laura E Schanberg,Bryce B Reeve, ","doi":"10.3899/jrheum.2025-0598","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0598","url":null,"abstract":"OBJECTIVEExplore congruence between child self-reported and caregiver-proxy reported health-related quality of life (HRQOL) over time in juvenile idiopathic arthritis (JIA) and childhood-onset systemic lupus erythematosus (cSLE) and identify factors associated with the level of congruence.METHODSData were from an observational, longitudinal cohort study conducted to validate the Patient- Reported Outcomes Measurement Information System® (PROMIS®) measures. HRQOL was assessed at baseline, 6 months, and 12 months. Four hundred fifty-one children (8-17 years) diagnosed with JIA or cSLE and their caregivers completed the PROMIS Pediatric Self-Report and Parent-Proxy measures, respectively. A one-way random-effects model was used to estimate the intraclass correlation coefficient (ICC) for congruence between child and caregiver reports, and multivariable mixed-effect models were used to identify associated demographic and clinical factors.RESULTSThe study cohort (87.1% JIA) had a mean age of 13.8 years and were 71.4% female. Across all HRQOL domains, child self-reported and caregiver-proxy reported mobility, physical activity, fatigue, pain interference, depressive symptoms, and psychological stress had moderate associations (ICC= 0.50-0.68), while child self-reported and caregiver-proxy-reported family relationships and anxiety were weakly associated (ICC= 0.34-0.42). Older children had higher congruence with their caregivers on symptom domains (0.25-0.75 points) than younger children; female children had higher congruence with their caregivers on psychological symptoms (-2.02 to -1.98 points) than male children.CONCLUSIONCaregivers provide complementary information on the physical aspects of HRQOL with a tendency to estimate worse symptoms and decreased functioning. Child self-report remains the gold standard for understanding HRQOL in pediatric populations with rheumatic diseases.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.3899/jrheum.2025-0475
Virginia Carrizo Abarza,Fadi Kharouf,Pankti Mehta,Shangyi Gao,Daniel Pereira,Richard J Cook,Denis Poddubnyy,Dafna D Gladman,Vinod Chandran
OBJECTIVEWe aimed to investigate the prevalence and incidence of atlantoaxial subluxation (AAS) in psoriatic arthritis (PsA), identify associated risk factors, and describe the clinical and radiographic characteristics of affected patients.METHODSWe included individuals from our observational cohort of PsA, excluding those with a history of trauma or cervical spine surgery. We calculated prevalence and incidence of AAS, and we used descriptive statistics to summarize and compare baseline demographic and disease-related characteristics between patients with and without AAS. Additionally, we used Cox regression with time-varying covariates to identify factors linked to AAS development and performed multivariable GEE analysis to assess associations with AAS.RESULTSAmong 1,535 PsA patients, 34 (2.21%) were identified with AAS, including 20 at baseline and 14 during follow-up, with an incidence of 1.16 per 1000 person-years. Patients with AAS had higher rates of radiographic sacroiliitis (71.0%) and greater peripheral joint damage. Elevated ESR was observed in 86.7% of cases. Cox regression identified radiographic sacroiliitis (HR 6.61, 95% CI 1.64-26.67) as the strongest predictor of AAS, while male sex was associated with a lower hazard (HR 0.42, 95% CI 0.07-0.89). In GEE analysis, radiographic sacroiliitis (OR 3.64, 95% CI 1.6-8.24) and higher modified Steinbrocker scores were associated with AAS, whereas older age (OR 0.95, 95% CI 0.93-0.98) and male sex (OR 0.40, 95% CI 0.17-0.92) were associated with lower ORs.CONCLUSIONAAS is an uncommon complication in PsA strongly associated with radiographic sacroiliitis and radiographic damage in peripheral joints.
目的探讨银屑病关节炎（PsA）中寰枢椎半脱位（AAS）的患病率和发病率，确定相关危险因素，并描述患者的临床和影像学特征。方法：我们纳入了PsA观察队列中的个体，排除了有创伤史或颈椎手术史的个体。我们计算了AAS的患病率和发病率，并使用描述性统计来总结和比较AAS患者和非AAS患者的基线人口统计学和疾病相关特征。此外，我们使用随时间变化的协变量Cox回归来确定与AAS发展相关的因素，并进行多变量GEE分析来评估与AAS的关联。结果在1535例PsA患者中，34例（2.21%）被确定为AAS，包括基线时的20例和随访期间的14例，发病率为1.16 / 1000人年。AAS患者有较高的骶髂炎发生率（71.0%）和更大的周围关节损伤。86.7%的病例ESR升高。Cox回归发现放射性骶髂炎（HR 6.61, 95% CI 1.64-26.67）是AAS的最强预测因子，而男性的风险较低（HR 0.42, 95% CI 0.07-0.89）。在GEE分析中，骶髂炎（OR 3.64, 95% CI 1.6-8.24）和较高的修正Steinbrocker评分与AAS相关，而年龄较大（OR 0.95, 95% CI 0.93-0.98）和男性（OR 0.40, 95% CI 0.17-0.92）与较低的OR相关。结论aas是一种罕见的PsA并发症，与骶髂炎和周围关节的影像学损害密切相关。
{"title":"Atlantoaxial Subluxation In Patients With Psoriatic Arthritis.","authors":"Virginia Carrizo Abarza,Fadi Kharouf,Pankti Mehta,Shangyi Gao,Daniel Pereira,Richard J Cook,Denis Poddubnyy,Dafna D Gladman,Vinod Chandran","doi":"10.3899/jrheum.2025-0475","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0475","url":null,"abstract":"OBJECTIVEWe aimed to investigate the prevalence and incidence of atlantoaxial subluxation (AAS) in psoriatic arthritis (PsA), identify associated risk factors, and describe the clinical and radiographic characteristics of affected patients.METHODSWe included individuals from our observational cohort of PsA, excluding those with a history of trauma or cervical spine surgery. We calculated prevalence and incidence of AAS, and we used descriptive statistics to summarize and compare baseline demographic and disease-related characteristics between patients with and without AAS. Additionally, we used Cox regression with time-varying covariates to identify factors linked to AAS development and performed multivariable GEE analysis to assess associations with AAS.RESULTSAmong 1,535 PsA patients, 34 (2.21%) were identified with AAS, including 20 at baseline and 14 during follow-up, with an incidence of 1.16 per 1000 person-years. Patients with AAS had higher rates of radiographic sacroiliitis (71.0%) and greater peripheral joint damage. Elevated ESR was observed in 86.7% of cases. Cox regression identified radiographic sacroiliitis (HR 6.61, 95% CI 1.64-26.67) as the strongest predictor of AAS, while male sex was associated with a lower hazard (HR 0.42, 95% CI 0.07-0.89). In GEE analysis, radiographic sacroiliitis (OR 3.64, 95% CI 1.6-8.24) and higher modified Steinbrocker scores were associated with AAS, whereas older age (OR 0.95, 95% CI 0.93-0.98) and male sex (OR 0.40, 95% CI 0.17-0.92) were associated with lower ORs.CONCLUSIONAAS is an uncommon complication in PsA strongly associated with radiographic sacroiliitis and radiographic damage in peripheral joints.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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