Pub Date : 2023-12-08DOI: 10.1097/ta.0000000000004227
Sina Asaadi, Kaushik Mukherjee, Ahmed M Abou-Zamzam, Liang Ji, Xian Luo-Owen, Maryam B Tabrizi, Richard D Catalano, Joseph J Dubose, Martin G Rosenthal
Tranexamic acid (TXA) is associated with lower mortality and transfusion requirements in trauma patients, but its role in thrombotic complications associated with vascular repairs remains unclear. We investigated whether TXA increases the risk of thrombosis-related technical failure (TRTF) in major vascular injuries (MVI).
{"title":"Tranexamic acid is not associated with a higher rate of thrombotic-related reintervention after major vascular injury repair.","authors":"Sina Asaadi, Kaushik Mukherjee, Ahmed M Abou-Zamzam, Liang Ji, Xian Luo-Owen, Maryam B Tabrizi, Richard D Catalano, Joseph J Dubose, Martin G Rosenthal","doi":"10.1097/ta.0000000000004227","DOIUrl":"https://doi.org/10.1097/ta.0000000000004227","url":null,"abstract":"Tranexamic acid (TXA) is associated with lower mortality and transfusion requirements in trauma patients, but its role in thrombotic complications associated with vascular repairs remains unclear. We investigated whether TXA increases the risk of thrombosis-related technical failure (TRTF) in major vascular injuries (MVI).","PeriodicalId":501845,"journal":{"name":"The Journal of Trauma and Acute Care Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138693368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1097/ta.0000000000004230
Keita Nakatsutsumi, Koji Morishita, Todd W Costantini, Tomohiro Adachi, Akira Suekane, Keisuke Suzuki, Mitsuaki Kojima, Makoto Arita, Yasuhiro Otomo
Disruption of intestinal barrier caused by intestinal ischemia due to hemorrhagic shock, is associated with the pathogenesis of multiple organ dysfunction (MOD) after severe trauma. Mesenteric lymph (ML) plays an important role as a route for transporting inflammatory mediators, including lipids. Post-biotics, such as 10-hydroxy-cis-12-octadecenoic acid (HYA), have received much attention as a treatment option. However, the relationship between post-biotics and MOD has yet to be clarified. The aim of the present study is to analyze lipid metabolites derived from gut microbiota in the intestinal ischemia/reperfusion (IR) rat model.
失血性休克导致的肠道缺血会破坏肠道屏障，这与严重创伤后多器官功能障碍（MOD）的发病机制有关。肠系膜淋巴（ML）作为运输炎症介质（包括脂质）的途径发挥着重要作用。生物后药物，如 10-羟基-顺式-12-十八碳烯酸（HYA），作为一种治疗选择受到广泛关注。然而，后生物制剂与 MOD 之间的关系尚未明确。本研究旨在分析肠道缺血再灌注（IR）大鼠模型中来自肠道微生物群的脂质代谢物。
{"title":"Analysis of lipid metabolites derived from gut microbiota in ischemia-reperfusion model.","authors":"Keita Nakatsutsumi, Koji Morishita, Todd W Costantini, Tomohiro Adachi, Akira Suekane, Keisuke Suzuki, Mitsuaki Kojima, Makoto Arita, Yasuhiro Otomo","doi":"10.1097/ta.0000000000004230","DOIUrl":"https://doi.org/10.1097/ta.0000000000004230","url":null,"abstract":"Disruption of intestinal barrier caused by intestinal ischemia due to hemorrhagic shock, is associated with the pathogenesis of multiple organ dysfunction (MOD) after severe trauma. Mesenteric lymph (ML) plays an important role as a route for transporting inflammatory mediators, including lipids. Post-biotics, such as 10-hydroxy-cis-12-octadecenoic acid (HYA), have received much attention as a treatment option. However, the relationship between post-biotics and MOD has yet to be clarified. The aim of the present study is to analyze lipid metabolites derived from gut microbiota in the intestinal ischemia/reperfusion (IR) rat model.","PeriodicalId":501845,"journal":{"name":"The Journal of Trauma and Acute Care Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138693374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1097/ta.0000000000004234
Mohammadreza Zarisfi, Reem Younes, Nijmeh Alsaadi, Zeyu Liu, Patricia Loughran, Kelly Williamson, Philip C Spinella, Susan Shea, Matthew R Rosengart, Elizabeth A Andraska, Matthew D Neal
Evidence suggests that variation in light exposure strongly influences the dynamic of inflammation, coagulation, and the immune system. Polytrauma induces systemic inflammation that can lead to end-organ injury. Here, we hypothesize that alterations in light exposure influence post-trauma inflammation, coagulopathy, and end-organ injury.
{"title":"Long wavelength light exposure reduces systemic inflammation coagulopathy, and acute organ injury following polytrauma in mice.","authors":"Mohammadreza Zarisfi, Reem Younes, Nijmeh Alsaadi, Zeyu Liu, Patricia Loughran, Kelly Williamson, Philip C Spinella, Susan Shea, Matthew R Rosengart, Elizabeth A Andraska, Matthew D Neal","doi":"10.1097/ta.0000000000004234","DOIUrl":"https://doi.org/10.1097/ta.0000000000004234","url":null,"abstract":"Evidence suggests that variation in light exposure strongly influences the dynamic of inflammation, coagulation, and the immune system. Polytrauma induces systemic inflammation that can lead to end-organ injury. Here, we hypothesize that alterations in light exposure influence post-trauma inflammation, coagulopathy, and end-organ injury.","PeriodicalId":501845,"journal":{"name":"The Journal of Trauma and Acute Care Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138693373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1097/ta.0000000000004226
Nathan N O'Hara, Robert V O'Toole, Katherine P Frey, Renan C Castillo, Joseph Cuschieri, Elliott R Haut, Gerard P Slobogean, Reza Firoozabadi, Ashley Christmas, William T Obremskey, Anthony R Carlini, Greg Gaski, Matthew E Kutcher, Debra Marvel, Deborah M Stein
The PREVENT CLOT trial concluded that thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin (LMWH) in preventing death after orthopaedic trauma. However, it was unclear if these results applied to patients at highest risk of thrombosis. Therefore, we assessed if the effect of aspirin versus LMWH differed based on patients' baseline risk of venous thromboembolism (VTE).
{"title":"Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopaedic trauma patients: a secondary analysis of the PREVENT CLOT trial.","authors":"Nathan N O'Hara, Robert V O'Toole, Katherine P Frey, Renan C Castillo, Joseph Cuschieri, Elliott R Haut, Gerard P Slobogean, Reza Firoozabadi, Ashley Christmas, William T Obremskey, Anthony R Carlini, Greg Gaski, Matthew E Kutcher, Debra Marvel, Deborah M Stein","doi":"10.1097/ta.0000000000004226","DOIUrl":"https://doi.org/10.1097/ta.0000000000004226","url":null,"abstract":"The PREVENT CLOT trial concluded that thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin (LMWH) in preventing death after orthopaedic trauma. However, it was unclear if these results applied to patients at highest risk of thrombosis. Therefore, we assessed if the effect of aspirin versus LMWH differed based on patients' baseline risk of venous thromboembolism (VTE).","PeriodicalId":501845,"journal":{"name":"The Journal of Trauma and Acute Care Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138693372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1097/ta.0000000000004235
R W G Dujardin, D J B Kleinveld, C E van den Brom, L M G Geeraedts, E Beijer, C Gaarder, K Brohi, S Stanworth, P I Johansson, J Stensballe, M Maegele, N P Juffermans
Female sex may provide a survival benefit after trauma, possibly attributable to protective effects of estrogen. This study aims to compare markers of coagulation between male and female trauma patients across different ages.
{"title":"Older females have increased mortality after trauma as compared to younger females and males, associated with increased fibrinolysis.","authors":"R W G Dujardin, D J B Kleinveld, C E van den Brom, L M G Geeraedts, E Beijer, C Gaarder, K Brohi, S Stanworth, P I Johansson, J Stensballe, M Maegele, N P Juffermans","doi":"10.1097/ta.0000000000004235","DOIUrl":"https://doi.org/10.1097/ta.0000000000004235","url":null,"abstract":"Female sex may provide a survival benefit after trauma, possibly attributable to protective effects of estrogen. This study aims to compare markers of coagulation between male and female trauma patients across different ages.","PeriodicalId":501845,"journal":{"name":"The Journal of Trauma and Acute Care Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138693369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1097/ta.0000000000004229
Katrina M Morgan, Elissa Abou-Khalil, Barbara A Gaines, Christine M Leeper
The contribution of the endothelium to trauma-induced coagulopathy has not been thoroughly investigated in injured children.
关于内皮对创伤引起的凝血病变的作用，尚未对受伤儿童进行深入研究。
{"title":"Endotheliopathy of Trauma in Children: The Association of Syndecan-1 with Injury and Poor Outcomes.","authors":"Katrina M Morgan, Elissa Abou-Khalil, Barbara A Gaines, Christine M Leeper","doi":"10.1097/ta.0000000000004229","DOIUrl":"https://doi.org/10.1097/ta.0000000000004229","url":null,"abstract":"The contribution of the endothelium to trauma-induced coagulopathy has not been thoroughly investigated in injured children.","PeriodicalId":501845,"journal":{"name":"The Journal of Trauma and Acute Care Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138693371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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