Baolan Ji, Shuwei Shi, Guanqi Gao, Yangang Wang, Bo Ban
Type 2 diabetes (T2D) and hypertension often coexist, and insulin resistance (IR) plays an important role in their pathological progression. An increasing number of studies have focused on the relationship between different IR indices and hypertension. A natural log transformation of the glucose disposal rate (loge GDR) has been proposed as a new model for insulin sensitivity in patients with T2D. The study aimed to explore the relationship between loge GDR and hypertension in T2D patients. This cross-sectional study included 1544 Chinese T2D patients. Clinical and biochemical characteristics were collected. The loge GDR was calculated based on triglycerides, urinary albumin to creatinine ratio, gamma-glutamyl transferase, and body mass index. Patients were categorized into hypertension and nonhypertension groups stratified by gender. Among both females and males, compared with the nonhypertension group, the level of loge GDR was significantly decreased in the hypertension group (both p < 0.001). As the loge GDR increased, the levels of systolic and diastolic blood pressure, and the prevalence of hypertension were obviously increased (all p < 0.001). Univariate analysis displayed that loge GDR was negatively related to hypertension (correlation coefficient: −0.243, p < 0.001 in females; correlation coefficient: −0.181, p < 0.001 in males). Furthermore, the logistic regression analysis showed that loge GDR was independently associated with hypertension (OR: 0.456; 95% CI: 0.224–0.927 in females; OR: 0.544; 95% CI: 0.314–0.941 in males). This study revealed that loge GDR was closely related to hypertension, which might help monitor and manage hypertension in T2D patients.
{"title":"Association Between a New Model of Insulin Sensitivity and Hypertension in Patients With Type 2 Diabetes: A Cross-Sectional Study","authors":"Baolan Ji, Shuwei Shi, Guanqi Gao, Yangang Wang, Bo Ban","doi":"10.1111/jch.70008","DOIUrl":"https://doi.org/10.1111/jch.70008","url":null,"abstract":"<p>Type 2 diabetes (T2D) and hypertension often coexist, and insulin resistance (IR) plays an important role in their pathological progression. An increasing number of studies have focused on the relationship between different IR indices and hypertension. A natural log transformation of the glucose disposal rate (log<sub>e</sub> GDR) has been proposed as a new model for insulin sensitivity in patients with T2D. The study aimed to explore the relationship between log<sub>e</sub> GDR and hypertension in T2D patients. This cross-sectional study included 1544 Chinese T2D patients. Clinical and biochemical characteristics were collected. The log<sub>e</sub> GDR was calculated based on triglycerides, urinary albumin to creatinine ratio, gamma-glutamyl transferase, and body mass index. Patients were categorized into hypertension and nonhypertension groups stratified by gender. Among both females and males, compared with the nonhypertension group, the level of log<sub>e</sub> GDR was significantly decreased in the hypertension group (both <i>p</i> < 0.001). As the log<sub>e</sub> GDR increased, the levels of systolic and diastolic blood pressure, and the prevalence of hypertension were obviously increased (all <i>p</i> < 0.001). Univariate analysis displayed that log<sub>e</sub> GDR was negatively related to hypertension (correlation coefficient: −0.243, <i>p</i> < 0.001 in females; correlation coefficient: −0.181, <i>p</i> < 0.001 in males). Furthermore, the logistic regression analysis showed that log<sub>e</sub> GDR was independently associated with hypertension (OR: 0.456; 95% CI: 0.224–0.927 in females; OR: 0.544; 95% CI: 0.314–0.941 in males). This study revealed that log<sub>e</sub> GDR was closely related to hypertension, which might help monitor and manage hypertension in T2D patients.</p>","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Riociguat is a drug that improves hemodynamic parameters and increases the exercise capacity of patients with chronic thromboembolic pulmonary hypertension (CTEPH). This meta-analysis evaluated cohort studies that measured changes in parameters such as the 6-minute walk distance (6MWD), mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), cardiac output (CO), and pulmonary arterial wedge pressure (PAWP). The study utilized cohort studies with a paired samples group design to measure the changes in these parameters. We searched for articles containing the keywords “Riociguat” and “Chronic thromboembolic pulmonary hypertension” in their titles in PubMed, Web of Science, Scopus, and ScienceDirect databases until May 2024. We conducted five meta-analyses to combine the mean difference values. We identified nine studies that examine the effects of Riociguat on patients. Analyzing data from 565 patients revealed that Riociguat increases the distance walked during the 6MWD test by an average of 35.86 m. After analyzing data from 717 patients, it was found that Riociguat reduces mPAP by an average of 9.23 mm Hg. Analyzing data from 586 patients, it was found that Riociguat reduces PVR by an average of 220.11