Zeynep AYVAT ÖCAL, R. Bakici, Orhan Meral, Zülal Öner, S. Öner
Amaç: Günümüzde yaş tahmini, biyolojik profil oluşturulmasında yararlanılan, adli bilimlerde kim-liklendirme amacıyla sıklıkla kullanılan ve önemli veriler sunan bir yöntemdir. Bu çalışmanın amacı, ISI Web of Knowledge-Science veritabanında yer alan yaş tahmini konusundaki eserlerin biblio-metrik analizini yaparak, disiplinler arası etkileşim ve araştırma trendlerini belirlemeye yönelik öneriler sunmaktır. Materyal ve metod: WoS veritabanında yer alan eserler arasından başlığında "age" sözcüğü ve bunun yanı sıra “estimation”, “determination”, “prediction” veya “assessment” sözcüklerinden herhangi birini içeren makaleler tespit edilmiştir. Veritabanının filtreleme özelliğinden yararlanılarak bu makalelerin yazım dili, yayın yılı, yayınlandığı dergi, makalenin yazarları, yazar kurumları, çalışmala-rın yapıldığı ülke ve makalelere yapılan atıf sayısı ile çalışmaların finansal destek alıp almadığı araştı-rıldı. Bulgular: -Çalışmamız kapsamını oluşturan 1020 makalenin, (n=990,%97.1) kadarının İngilizce olarak yayınlandığı, eserlerin yayınlandığı günden bugüne toplam 23704 atıf aldığı, incelenen makalelerin (n=993,%97.4) kadarının SCI-E kapsamında indekslenen dergilerde yer aldığı ve en çok çalışmanın (n=145, %10.4) makale ile Almanya’da yapıldığı bilgisine ulaşıldı. Sonuç: Çalışma verileri, WoS veritabanında yer alan makalelerin analiz edilmesi sonucu elde edilen veriler ışığında ülkeler, kurumlar ve araştırmacıların adli yaş tahmini konusundaki bibliometrik analizini ortaya koymaktadır. Sunulan çalışma, bu alanda yapılan ilk çalışma niteliğindedir. Elde edilen bilgiler araştırmacılar, akademisyenler ve diğer paydaşlar için değerli bir kaynak olabilir ve gelecekteki yaş tahmini araştırmalarının yönlendirilmesine katkı sağlayabilir.
{"title":"Forensic Age Estimation: A Bibliometric Analysis of Research Studies in Web of Science Database","authors":"Zeynep AYVAT ÖCAL, R. Bakici, Orhan Meral, Zülal Öner, S. Öner","doi":"10.35440/hutfd.1375401","DOIUrl":"https://doi.org/10.35440/hutfd.1375401","url":null,"abstract":"Amaç: Günümüzde yaş tahmini, biyolojik profil oluşturulmasında yararlanılan, adli bilimlerde kim-liklendirme amacıyla sıklıkla kullanılan ve önemli veriler sunan bir yöntemdir. Bu çalışmanın amacı, ISI Web of Knowledge-Science veritabanında yer alan yaş tahmini konusundaki eserlerin biblio-metrik analizini yaparak, disiplinler arası etkileşim ve araştırma trendlerini belirlemeye yönelik öneriler sunmaktır. Materyal ve metod: WoS veritabanında yer alan eserler arasından başlığında \"age\" sözcüğü ve bunun yanı sıra “estimation”, “determination”, “prediction” veya “assessment” sözcüklerinden herhangi birini içeren makaleler tespit edilmiştir. Veritabanının filtreleme özelliğinden yararlanılarak bu makalelerin yazım dili, yayın yılı, yayınlandığı dergi, makalenin yazarları, yazar kurumları, çalışmala-rın yapıldığı ülke ve makalelere yapılan atıf sayısı ile çalışmaların finansal destek alıp almadığı araştı-rıldı. Bulgular: -Çalışmamız kapsamını oluşturan 1020 makalenin, (n=990,%97.1) kadarının İngilizce olarak yayınlandığı, eserlerin yayınlandığı günden bugüne toplam 23704 atıf aldığı, incelenen makalelerin (n=993,%97.4) kadarının SCI-E kapsamında indekslenen dergilerde yer aldığı ve en çok çalışmanın (n=145, %10.4) makale ile Almanya’da yapıldığı bilgisine ulaşıldı. Sonuç: Çalışma verileri, WoS veritabanında yer alan makalelerin analiz edilmesi sonucu elde edilen veriler ışığında ülkeler, kurumlar ve araştırmacıların adli yaş tahmini konusundaki bibliometrik analizini ortaya koymaktadır. Sunulan çalışma, bu alanda yapılan ilk çalışma niteliğindedir. Elde edilen bilgiler araştırmacılar, akademisyenler ve diğer paydaşlar için değerli bir kaynak olabilir ve gelecekteki yaş tahmini araştırmalarının yönlendirilmesine katkı sağlayabilir.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"37 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139278918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Lower respiratory system infections are highly common in young children and may require inpatient treatment. Studies have shown that patients treated and followed up for lower respiratory system infections have low levels of vitamin A and Vitamin D. In our study, we aimed to determine whether the deficiencies of these vitamins are risk factors for the development of lower respiratory system infections by comparing the serum vitamin A and vitamin D levels of patients 0-36months with lower respiratory tract infection and healthy children. Materials and Method The study included 82 children who applied to pediatric outpatient clinic between February 1st 2020 and June 30th 2020 with lower respiratory tract infection between the age 0-36 months, who gave blood sample for determination of serum vitamin A and vitamin D levels. 58 healthy children who applied to the outpatient clinic for routine check-up were determined as the control group. Age, sex, height and weight of all children were recorded. Results The average vitamin D level of those in the lower respiratory tract infection group was found to be 15.96±7.49ng/ml and those in the healthy group had average vitamin D levels of 32.19±14.27 ng/ml, showing that the sick group had statistically significantly lower levels of vitamin D (p=0.0001). The average vitamin A level of those in the sick group was found to be 170.42±60.42 ng/ml, whereas those in the control group had average vitamin A levels of 284.42±71.2 ng/ml, which showed that those in the sick group had statistically significantly low levels of vitamin A (p=0.0001). Our study showed that there is a positive statistically meaningful correlation between the vitamin D variable and the vitamin A variable (r=0.432, p=0.0001). Conclusions Our study is the only study in the literature comparing both the vitamin A and vitamin D levels of patients with lower respiratory tract infection. Vitamin A and vitamin D levels of patients with lower respiratory tract infections are found to be lower compared to healthy children, therefore we predict that controlling the vitamin levels of such patient and giving the appropriate treatment when needed, will lower the morbidity and mortality caused by lower respiratory tract infections.
背景下呼吸系统感染在幼儿中非常常见，可能需要住院治疗。我们的研究旨在通过比较 0-36 个月的下呼吸道感染患者和健康儿童的血清维生素 A 和维生素 D 水平，确定这些维生素的缺乏是否是导致下呼吸道感染的危险因素。 材料与方法 本研究纳入了 2020 年 2 月 1 日至 2020 年 6 月 30 日期间到儿科门诊就诊的 82 名 0-36 个月大的下呼吸道感染患儿，他们都提供了血样以测定血清维生素 A 和维生素 D 水平。58 名到门诊进行常规检查的健康儿童作为对照组。记录所有儿童的年龄、性别、身高和体重。 结果 发现下呼吸道感染组的平均维生素 D 水平为（15.96±7.49）ng/ml，健康组的平均维生素 D 水平为（32.19±14.27）ng/ml，表明患病组的维生素 D 水平显著低于健康组（P=0.0001）。研究发现，患病组的维生素 A 平均水平为（170.42±60.42）纳克/毫升，而对照组的维生素 A 平均水平为（284.42±71.2）纳克/毫升，这表明患病组的维生素 A 水平在统计学上明显偏低（P=0.0001）。我们的研究表明，维生素 D 变量与维生素 A 变量之间存在统计学意义上的正相关（r=0.432，p=0.0001）。 结论 我们的研究是文献中唯一一项比较下呼吸道感染患者维生素 A 和维生素 D 水平的研究。与健康儿童相比，下呼吸道感染患者的维生素 A 和维生素 D 水平较低，因此我们预测，控制此类患者的维生素水平并在必要时给予适当治疗，将降低下呼吸道感染的发病率和死亡率。
{"title":"Çocuk Servisinde Yatırılarak Tedavi Edilen Alt Solunum Yolu Enfeksiyonu Tanılı 0 – 36 Ay Arası Çocukların Vitamin A Ve Vitamin D Düzeylerinin Aynı Yaş Grubu Sağlıklı Çocuklar Ile Karşılaştırılması","authors":"Harun Çatak, Abdulrahman Özel, Övgü Büke, Özlem Bostan Gayret, Meltem Erol","doi":"10.35440/hutfd.1327349","DOIUrl":"https://doi.org/10.35440/hutfd.1327349","url":null,"abstract":"Background Lower respiratory system infections are highly common in young children and may require inpatient treatment. Studies have shown that patients treated and followed up for lower respiratory system infections have low levels of vitamin A and Vitamin D. In our study, we aimed to determine whether the deficiencies of these vitamins are risk factors for the development of lower respiratory system infections by comparing the serum vitamin A and vitamin D levels of patients 0-36months with lower respiratory tract infection and healthy children. Materials and Method The study included 82 children who applied to pediatric outpatient clinic between February 1st 2020 and June 30th 2020 with lower respiratory tract infection between the age 0-36 months, who gave blood sample for determination of serum vitamin A and vitamin D levels. 58 healthy children who applied to the outpatient clinic for routine check-up were determined as the control group. Age, sex, height and weight of all children were recorded. Results The average vitamin D level of those in the lower respiratory tract infection group was found to be 15.96±7.49ng/ml and those in the healthy group had average vitamin D levels of 32.19±14.27 ng/ml, showing that the sick group had statistically significantly lower levels of vitamin D (p=0.0001). The average vitamin A level of those in the sick group was found to be 170.42±60.42 ng/ml, whereas those in the control group had average vitamin A levels of 284.42±71.2 ng/ml, which showed that those in the sick group had statistically significantly low levels of vitamin A (p=0.0001). Our study showed that there is a positive statistically meaningful correlation between the vitamin D variable and the vitamin A variable (r=0.432, p=0.0001). Conclusions Our study is the only study in the literature comparing both the vitamin A and vitamin D levels of patients with lower respiratory tract infection. Vitamin A and vitamin D levels of patients with lower respiratory tract infections are found to be lower compared to healthy children, therefore we predict that controlling the vitamin levels of such patient and giving the appropriate treatment when needed, will lower the morbidity and mortality caused by lower respiratory tract infections.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"17 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Covid-19 has undergone many mutations over time. The most prominent variants have been the Alpha, Beta, Delta, Gamma, and finally, the Omicron variants. This study aims to determine the availability of neutrophil/lymphocyte rate (NLR), platelet/lymphocyte rate (PLR) and Systemic Inflammatory Index (SII), prog-nostic and diagnostic significance, in the differentiation of variants in pediatric Covid-19 patients. Materials and Methods: In this retrospective study, 141 pediatric patients who were found to be positive for Covid-19 in Harran University Medical Faculty Hospital between January 2021 and April 2022 were included. A control group was formed from 107 healthy children selected from among those who applied to the general pediatric outpatient clinic for routine health evaluations. Results: When the age distribution of the patients was examined, the median was 7.0 (0.1-18) years. When the variants were compared, there was a significant difference between lymphocyte values, while leukocyte, neu-trophil, C-reactive protein (CRP) and Mean Platelet Volume (MPV) did not change significantly. At the same time, there was a statistically significant difference between NLR, PLR and SII variants in Covid-19 positive patients (p<0.05); It was found that CRP, CRP/albumin rate (CAR), and MPV values did not change significantly between variants (p>0.05). It was observed that the NLR, PLR and SII delta variants increased significantly compared to the omicron variant (p<0.05). CRP and CAR were significantly increased in the severe clinical course compared to the asymptomatic group (p<0.05). Conclusions: In our study, it was seen that patients with delta variant had higher NLR, PLR and SII values compared to omicron variant when viewed from the point of view of Covid-19 variants. Therefore, we think that during the diagnosis of Covid-19 accompanied by these parameters, variant analysis can be performed, especially in terms of the delta variant, and it will shed light on the differential diagnosis, appropriate treatment, and measures to be taken by early and simple means.
{"title":"Sistemik İnflamatuar İndeks, Nötrofil-Lenfosit Oranı ve Trombosit-Lenfosit Oranı Pediatrik Covid-19 Varyantlarını Saptayabilir mi?","authors":"Nurgül Ataş, Emrullah Kilinc, Ömer Yalçin","doi":"10.35440/hutfd.1365963","DOIUrl":"https://doi.org/10.35440/hutfd.1365963","url":null,"abstract":"Background: Covid-19 has undergone many mutations over time. The most prominent variants have been the Alpha, Beta, Delta, Gamma, and finally, the Omicron variants. This study aims to determine the availability of neutrophil/lymphocyte rate (NLR), platelet/lymphocyte rate (PLR) and Systemic Inflammatory Index (SII), prog-nostic and diagnostic significance, in the differentiation of variants in pediatric Covid-19 patients. Materials and Methods: In this retrospective study, 141 pediatric patients who were found to be positive for Covid-19 in Harran University Medical Faculty Hospital between January 2021 and April 2022 were included. A control group was formed from 107 healthy children selected from among those who applied to the general pediatric outpatient clinic for routine health evaluations. Results: When the age distribution of the patients was examined, the median was 7.0 (0.1-18) years. When the variants were compared, there was a significant difference between lymphocyte values, while leukocyte, neu-trophil, C-reactive protein (CRP) and Mean Platelet Volume (MPV) did not change significantly. At the same time, there was a statistically significant difference between NLR, PLR and SII variants in Covid-19 positive patients (p<0.05); It was found that CRP, CRP/albumin rate (CAR), and MPV values did not change significantly between variants (p>0.05). It was observed that the NLR, PLR and SII delta variants increased significantly compared to the omicron variant (p<0.05). CRP and CAR were significantly increased in the severe clinical course compared to the asymptomatic group (p<0.05). Conclusions: In our study, it was seen that patients with delta variant had higher NLR, PLR and SII values compared to omicron variant when viewed from the point of view of Covid-19 variants. Therefore, we think that during the diagnosis of Covid-19 accompanied by these parameters, variant analysis can be performed, especially in terms of the delta variant, and it will shed light on the differential diagnosis, appropriate treatment, and measures to be taken by early and simple means.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"27 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139278817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arzu Kayış, Zerife Orhan, Burak Küçük, A. Doğaner, Murat Aral
Amaç: Yoğun bakım üniteleri Acinetobacter baumannii'nin neden olduğu enfeksiyonlardan en sık etkilenen alanlardır. Hızlı bir şekilde antimikrobiyal direnç geliştirme eğilimi nedeniyle ciddi terapötik sorunlara yol açmaktadır. Bu çalışmanın amacı yoğun bakım ünitelerinden izole edilen Acinetobacter baumannii suşlarının dört yıllık süreçteki antibiyotik duyarlılıklarını belirlemektir. Materyal ve Metod: Ocak 2018–Aralık 2021 yılları arasında yoğun bakım ünitelerinden tıbbi mikrobiyoloji laboratuvarına gönderilen çeşitli örneklerden izole edilen Acinetobacter baumannii suşları çalışmaya dahil edilmiştir. Bakteri tanımlanması ve antibiyotik duyarlılık testleri standart mikrobiyolojik yöntemler ve otomatize sistemler kullanılarak yapılmıştır. Antibiyotik direncinde 2018 ile 2021 yılı verileri Ki-Kare ve Fisher Exact test ile karşılaştırılmış ve p<0.05 anlamlı olarak kabul edilmiştir. Bulgular: Toplam 1900 Acinetobacter baumannii suşu çalışmaya dahil edilmiştir. Bu suşlar en sık trakeal aspirat kültür örneklerinden (1011; %53) izole edilmiştir. Yoğun bakım arasında da en sık Anesteziyoloji ve Reanimasyon yoğun bakım ünitesinden (697; %37) izole edildiği saptanmıştır. 2018 yılı ile 2021 yılı karşılaştırıldığında Acinetobacter baumannii’de antibiyotiklere karşı direnç oranının arttığı görülmüştür. İstatistiksel olarak en anlamlı direnç artışı amikasin, trimetoprim/ sulfametoksazol ve levofloksasinde saptanmıştır (p<0.001). Sonuç: Çalışmamızda Acinetobacter baumannii suşlarında antibiyotiklere direncin yüksek olduğu görülmektedir. Antibiyotik duyarlılık sonuçlarının düzenli olarak takip edilmesi ve raporlanması, hekimlerin antibiyotik kullanım politikalarını belirlemelerine ve enfeksiyon kontrol önlemleri almalarına olanak tanıyacaktır.
{"title":"Acinetobacter baumannii Strains Isolated from Various Clinical Samples of Patients Admitted to the Intensive Care Unit and Four-Year Resistance Profiles","authors":"Arzu Kayış, Zerife Orhan, Burak Küçük, A. Doğaner, Murat Aral","doi":"10.35440/hutfd.1336319","DOIUrl":"https://doi.org/10.35440/hutfd.1336319","url":null,"abstract":"Amaç: Yoğun bakım üniteleri Acinetobacter baumannii'nin neden olduğu enfeksiyonlardan en sık etkilenen alanlardır. Hızlı bir şekilde antimikrobiyal direnç geliştirme eğilimi nedeniyle ciddi terapötik sorunlara yol açmaktadır. Bu çalışmanın amacı yoğun bakım ünitelerinden izole edilen Acinetobacter baumannii suşlarının dört yıllık süreçteki antibiyotik duyarlılıklarını belirlemektir. Materyal ve Metod: Ocak 2018–Aralık 2021 yılları arasında yoğun bakım ünitelerinden tıbbi mikrobiyoloji laboratuvarına gönderilen çeşitli örneklerden izole edilen Acinetobacter baumannii suşları çalışmaya dahil edilmiştir. Bakteri tanımlanması ve antibiyotik duyarlılık testleri standart mikrobiyolojik yöntemler ve otomatize sistemler kullanılarak yapılmıştır. Antibiyotik direncinde 2018 ile 2021 yılı verileri Ki-Kare ve Fisher Exact test ile karşılaştırılmış ve p<0.05 anlamlı olarak kabul edilmiştir. Bulgular: Toplam 1900 Acinetobacter baumannii suşu çalışmaya dahil edilmiştir. Bu suşlar en sık trakeal aspirat kültür örneklerinden (1011; %53) izole edilmiştir. Yoğun bakım arasında da en sık Anesteziyoloji ve Reanimasyon yoğun bakım ünitesinden (697; %37) izole edildiği saptanmıştır. 2018 yılı ile 2021 yılı karşılaştırıldığında Acinetobacter baumannii’de antibiyotiklere karşı direnç oranının arttığı görülmüştür. İstatistiksel olarak en anlamlı direnç artışı amikasin, trimetoprim/ sulfametoksazol ve levofloksasinde saptanmıştır (p<0.001). Sonuç: Çalışmamızda Acinetobacter baumannii suşlarında antibiyotiklere direncin yüksek olduğu görülmektedir. Antibiyotik duyarlılık sonuçlarının düzenli olarak takip edilmesi ve raporlanması, hekimlerin antibiyotik kullanım politikalarını belirlemelerine ve enfeksiyon kontrol önlemleri almalarına olanak tanıyacaktır.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kronik koroner sendromlar (KKS), kliniğinde uzun süreli değişikliğin olmadığı koroner arter hastalıklarıdır (KAH). Sık görülmekte ve hastaların hayat kalitesini olumsuz etkilemektedir. En sık etiyolojik eden aterosklerozdur. En önemli semptomu göğüs ağrısıdır. Tanısında anamnez ve fizik muayene genellikle tanı koydurucudur. Orta derecede KAH şüphesi olanlar tanı testleri karar vermede yol göstericidir. Tanıda çok kesitli bilgisayarı tomografi kullanımı öne çıkmaktadır. Tedavide anatomik tanıdan çok fonksiyonel tanı yöntemlerinin kullanılması önerilmektedir. Esas tedavi koruyucu önlemlerin uygulanması ile birlikte medikal tedavidir. Medikal tedavinin yetersiz tedavinin yetersiz kaldığı olgularda girişimsel tedaviler yapılması önerilmektedir. KKS prognoz oldukça iyidir.
{"title":"Chronic Coronary Syndromes","authors":"İbrahim Halil Toprak, R. Demi̇rbağ","doi":"10.35440/hutfd.1257611","DOIUrl":"https://doi.org/10.35440/hutfd.1257611","url":null,"abstract":"Kronik koroner sendromlar (KKS), kliniğinde uzun süreli değişikliğin olmadığı koroner arter hastalıklarıdır (KAH). Sık görülmekte ve hastaların hayat kalitesini olumsuz etkilemektedir. En sık etiyolojik eden aterosklerozdur. En önemli semptomu göğüs ağrısıdır. Tanısında anamnez ve fizik muayene genellikle tanı koydurucudur. Orta derecede KAH şüphesi olanlar tanı testleri karar vermede yol göstericidir. Tanıda çok kesitli bilgisayarı tomografi kullanımı öne çıkmaktadır. Tedavide anatomik tanıdan çok fonksiyonel tanı yöntemlerinin kullanılması önerilmektedir. Esas tedavi koruyucu önlemlerin uygulanması ile birlikte medikal tedavidir. Medikal tedavinin yetersiz tedavinin yetersiz kaldığı olgularda girişimsel tedaviler yapılması önerilmektedir. KKS prognoz oldukça iyidir.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The aim of this study early recognize diabetic nephropathy by ultrasound elastography.This study was to predict the possibility of developing diabetic nephropathy without the need for renal biopsy. Methods:This study included 100 patients and 100 healthy volunteers. Shear wave elastography examination were taken of the renal parenchyma and the Resistive Index values were taken renal artery. Results:.In the patient group, the elastography values were measured as 7.02±2.15 kPa in the right kidney parenchyma and 6.90±2.09 kPa in the left. In the control group, the elasticity values were measured as 4.14±0.98 kPa in the right kidney parenchyma and 4.11±0.85 kPa in the left. The RI mean values were determined as 0.59±0.05 in the right kidney and 0.59±0.04 in the left kidney in the patient group and 0.52±0.05 in the right kidney and 0.52±0.05 in the left kidney in the control group. Conclusion: The elastography values and the RI values were significantly higher in the patients with Type 2 DM than in the control group. Thus, it can be concluded that it is possible to determine renal fibrosis and predict the possibility of diabetic nephropathy development with the non-invasive methods of SWE and colour Doppler US, without the need for biopsy.
导言本研究的目的是通过超声弹性成像技术早期识别糖尿病肾病。本研究旨在预测发生糖尿病肾病的可能性，而无需进行肾活检。 方法：本研究包括 100 名患者和 100 名健康志愿者。对肾实质进行剪切波弹性成像检查，并测量肾动脉的电阻指数值。 结果：.在患者组中，右肾实质的弹性成像值为 7.02±2.15 kPa，左肾实质的弹性成像值为 6.90±2.09 kPa。在对照组中，右肾实质的弹性值为 4.14±0.98 kPa，左肾实质的弹性值为 4.11±0.85 kPa。患者组右肾的 RI 平均值为 0.59±0.05，左肾为 0.59±0.04；对照组右肾的 RI 平均值为 0.52±0.05，左肾为 0.52±0.05。 结论2 型糖尿病患者的弹性成像值和 RI 值明显高于对照组。因此，可以得出结论，利用 SWE 和彩色多普勒超声这种无创方法，可以确定肾脏纤维化情况并预测糖尿病肾病发展的可能性，而无需进行活组织检查。
{"title":"Evaluation of Kidneys with Renal Doppler Ultrasonography and Ultrasound Elastography in Patients with Type 2 Diabetes Mellitus","authors":"Atakan Kirteke, Sunay Sibel Karayol, A. Duşak, Canan Çelebi, Hatice İncebi̇yi̇k","doi":"10.35440/hutfd.1320159","DOIUrl":"https://doi.org/10.35440/hutfd.1320159","url":null,"abstract":"Introduction: The aim of this study early recognize diabetic nephropathy by ultrasound elastography.This study was to predict the possibility of developing diabetic nephropathy without the need for renal biopsy. Methods:This study included 100 patients and 100 healthy volunteers. Shear wave elastography examination were taken of the renal parenchyma and the Resistive Index values were taken renal artery. Results:.In the patient group, the elastography values were measured as 7.02±2.15 kPa in the right kidney parenchyma and 6.90±2.09 kPa in the left. In the control group, the elasticity values were measured as 4.14±0.98 kPa in the right kidney parenchyma and 4.11±0.85 kPa in the left. The RI mean values were determined as 0.59±0.05 in the right kidney and 0.59±0.04 in the left kidney in the patient group and 0.52±0.05 in the right kidney and 0.52±0.05 in the left kidney in the control group. Conclusion: The elastography values and the RI values were significantly higher in the patients with Type 2 DM than in the control group. Thus, it can be concluded that it is possible to determine renal fibrosis and predict the possibility of diabetic nephropathy development with the non-invasive methods of SWE and colour Doppler US, without the need for biopsy.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139351583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Bayraktar, A. Güzelçi̇çek, Ali Öztürk, Mehmet Bayraktar, Hamza Erdoğdu
Background: Pneumonia causes the majority of acute respiratory distress syndrome (ARDS) cases. The microbes that cause pneumonia are very diverse. In addition to DNA, RNA viruses, Gram-negative and Gram-positive bacteria cause two types of cytokine imbalances, anti-inflammatory and pro-inflammatory. It can also influence the progno-sis of sepsis and other infectious diseases. This study aims to search for 8-hydroxy-2'-deoxyguanosine (8-OHdG), IL-21, IL-23, and c-reactive protein (CRP) and compare cytokine levels. It is also to determine if Pediatric pneumonia patients CRP and cytokine levels correlate with results. Materials and Methods: In the study, blood was drawn from approximately 43 pediatric pneumonia patients and 43 healthy controls who came to the pediatric clinic to investigate serum IL-21, IL-23, 8-OHdG, and CRP levels. The levels of biomarkers were determined by ELISA method. Serum CRP levels were measured using the ATELLICA IM Analyzer. Results: Serum CRP, 8-OHdG, IL-21 and IL-23 levels were significantly higher in the pediatric pneumonia patient group than in the control group. Conclusions: Increased serum IL-21, IL-23, 8-OHdG and CRP expression in pediatric pneumonia patients is a poten-tial determinant suggesting that IL-21, IL-23-related cytokines may play a role in endothelial cell activation reported in patients. Increased 8-OHdG oxidative stress is more pronounced in patients without pediatric pneumonia while pro inflammatory cytokines are higher in pediatric pneumonia patients. However, it is used as a possible therapeu-tic target to reduce inflammation. Further study on the impact of these findings on comorbidities with larger num-ber test size is needed
{"title":"Serum Levels of IL-21, IL-23 and 8-hydroxy-2′-deoxyguanosine in Pediatric Severe Pneumonia Cases","authors":"N. Bayraktar, A. Güzelçi̇çek, Ali Öztürk, Mehmet Bayraktar, Hamza Erdoğdu","doi":"10.35440/hutfd.1285583","DOIUrl":"https://doi.org/10.35440/hutfd.1285583","url":null,"abstract":"Background: Pneumonia causes the majority of acute respiratory distress syndrome (ARDS) cases. The microbes that cause pneumonia are very diverse. In addition to DNA, RNA viruses, Gram-negative and Gram-positive bacteria cause two types of cytokine imbalances, anti-inflammatory and pro-inflammatory. It can also influence the progno-sis of sepsis and other infectious diseases. This study aims to search for 8-hydroxy-2'-deoxyguanosine (8-OHdG), IL-21, IL-23, and c-reactive protein (CRP) and compare cytokine levels. It is also to determine if Pediatric pneumonia patients CRP and cytokine levels correlate with results. Materials and Methods: In the study, blood was drawn from approximately 43 pediatric pneumonia patients and 43 healthy controls who came to the pediatric clinic to investigate serum IL-21, IL-23, 8-OHdG, and CRP levels. The levels of biomarkers were determined by ELISA method. Serum CRP levels were measured using the ATELLICA IM Analyzer. Results: Serum CRP, 8-OHdG, IL-21 and IL-23 levels were significantly higher in the pediatric pneumonia patient group than in the control group. Conclusions: Increased serum IL-21, IL-23, 8-OHdG and CRP expression in pediatric pneumonia patients is a poten-tial determinant suggesting that IL-21, IL-23-related cytokines may play a role in endothelial cell activation reported in patients. Increased 8-OHdG oxidative stress is more pronounced in patients without pediatric pneumonia while pro inflammatory cytokines are higher in pediatric pneumonia patients. However, it is used as a possible therapeu-tic target to reduce inflammation. Further study on the impact of these findings on comorbidities with larger num-ber test size is needed","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139357465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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