Vidyulatha Ch, Lathesh N, Govardhan Reddy Y, Dharani Ch, Sri Vidya G, Rahaman Hasanur
The current study aims to prepare an herbal ointment using several extracts of the complete Indigofera aspalathoides plant and assess the extracts' antimicrobial effectiveness for psoriasis. The entire plant's morphological and physiochemical characteristics were evaluated. Different extracts of powdered whole plant were made, and these extracts underwent phytochemical analysis. Alkaloids, carbohydrates, flavonoids, steroids, and other phytoconstituents were all present in the ethanolic extract. The extract's antimicrobial activity was examined throughout. Even at low concentrations, the ethanol and acetone extracts demonstrated promising efficacy and a maximum zone of inhibition. The antifungal activity of the ethanolic extract was assessed at 4%w/w and 2%w/w concentrations in an ointment formulation. The antifungal activity of the ointment made with ethanolic extract was on par with that of regular clobetasol cream. The ethanol extract cream's activity was shown to outperform that of the typical ointment.
{"title":"Formulation and Evaluation of herbal ointment to treat psoriasis with Indigofera aspalathoides","authors":"Vidyulatha Ch, Lathesh N, Govardhan Reddy Y, Dharani Ch, Sri Vidya G, Rahaman Hasanur","doi":"10.26452/fjphs.v4i2.620","DOIUrl":"https://doi.org/10.26452/fjphs.v4i2.620","url":null,"abstract":"The current study aims to prepare an herbal ointment using several extracts of the complete Indigofera aspalathoides plant and assess the extracts' antimicrobial effectiveness for psoriasis. The entire plant's morphological and physiochemical characteristics were evaluated. Different extracts of powdered whole plant were made, and these extracts underwent phytochemical analysis. Alkaloids, carbohydrates, flavonoids, steroids, and other phytoconstituents were all present in the ethanolic extract. The extract's antimicrobial activity was examined throughout. Even at low concentrations, the ethanol and acetone extracts demonstrated promising efficacy and a maximum zone of inhibition. The antifungal activity of the ethanolic extract was assessed at 4%w/w and 2%w/w concentrations in an ointment formulation. The antifungal activity of the ointment made with ethanolic extract was on par with that of regular clobetasol cream. The ethanol extract cream's activity was shown to outperform that of the typical ointment.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":" 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archana B, Sahithi Sri Charani Yallapragada, Sony Pawar, Sathvika D, Sathwika Gotham
Niosomes, also known as nonionic surfactant vesicles, are one of the many carriers used to carry drug molecules to their target sites. They can hold both hydrophilic and hydrophobic medicines. Indapamide is an angiotensin II type 1 receptor (AT1) antagonist medication primarily used to treat high blood pressure. Niosomes containing Indapamide were created utilizing the thin film hydration process with various cholesterol concentrations and nonionic surfactants (span 60). All noisome formulations were assessed for entrapment efficiency, drug content, reproducibility, vesicular diameter, shape and size distribution microphotography, FTIR analysis, and in vitro release experiments. The results indicate that in all of the created niosomal formulations, as the surfactant content increases, the entrapment efficiency also increases. The drug content ranged between 90.06±0.57 and 96.15±0.42, with a low standard deviation. Niosomes range in size from 0.280±0.098µm to 0.299±0.044µm and have a spherical shape. The IR spectrum analysis indicated no interaction between the medication and the formulation ingredients. Membrane diffusion cells were used to study the in vitro dissolution parameters. The results demonstrate that formulation F6 had a better-controlled release action than other formulations, with an 'n' value of 0.917, indicating that the medication was released using zero-order kinetics.
{"title":"Formulation, Evaluation, and Characterization of Indapamide Niosomes","authors":"Archana B, Sahithi Sri Charani Yallapragada, Sony Pawar, Sathvika D, Sathwika Gotham","doi":"10.26452/fjphs.v4i2.609","DOIUrl":"https://doi.org/10.26452/fjphs.v4i2.609","url":null,"abstract":"Niosomes, also known as nonionic surfactant vesicles, are one of the many carriers used to carry drug molecules to their target sites. They can hold both hydrophilic and hydrophobic medicines. Indapamide is an angiotensin II type 1 receptor (AT1) antagonist medication primarily used to treat high blood pressure. Niosomes containing Indapamide were created utilizing the thin film hydration process with various cholesterol concentrations and nonionic surfactants (span 60). All noisome formulations were assessed for entrapment efficiency, drug content, reproducibility, vesicular diameter, shape and size distribution microphotography, FTIR analysis, and in vitro release experiments. The results indicate that in all of the created niosomal formulations, as the surfactant content increases, the entrapment efficiency also increases. The drug content ranged between 90.06±0.57 and 96.15±0.42, with a low standard deviation. Niosomes range in size from 0.280±0.098µm to 0.299±0.044µm and have a spherical shape. The IR spectrum analysis indicated no interaction between the medication and the formulation ingredients. Membrane diffusion cells were used to study the in vitro dissolution parameters. The results demonstrate that formulation F6 had a better-controlled release action than other formulations, with an 'n' value of 0.917, indicating that the medication was released using zero-order kinetics.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":" 950","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140989235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archana B, Sri Chaya Reddy Konda, Amulya Shreshta Gadapati, Sadiq Abubakar
The current project aims to formulate and evaluate econazole-based transdermal patches. At present, the market offers econazole tablets for purchase. These dose formulations do not elicit cooperation from patients. Therefore, because transdermal drug administration systems are simple to use and improve patient compliance, they have begun to gain momentum as innovative drug delivery methods. The research aims to use polymers like HPMC K 15M, HPMC K 100M, and HPMC K200M to build and evaluate econazole transdermal patches. The solvent casting technique for making econazole transdermal patches. To determine the formulation's approximate drug content, an appropriate in vitro technique is employed to investigate the drug release pattern. To delay the drug's release over a long period. To develop a dose form that prevents patient compliance and reduces dosage frequency for optimal drug utilization. Tween 80 plasticizer concentration was essential for patch creation and separation characteristics. For use as a plasticizer and solubility enhancer during the shelf life term, Tween 80 is chosen. The formulation F-5 was optimized for the desired qualities and was an effective batch.
本项目旨在配制和评估以益康唑为基础的透皮贴剂。目前，市场上有售益康唑片剂。这些剂型无法获得患者的配合。因此，由于透皮给药系统使用简单，且能提高患者的依从性，因此作为创新的给药方法，透皮给药系统已开始获得越来越多的关注。本研究旨在使用 HPMC K 15M、HPMC K 100M 和 HPMC K 200M 等聚合物来制作和评估益康唑透皮贴片。采用溶剂浇注技术制作益康唑透皮贴剂。为了确定制剂的大致药物含量，采用了适当的体外技术来研究药物释放模式。长期延缓药物释放。开发一种剂型，防止患者依从性，减少服药次数，以达到最佳药物利用率。Tween 80 增塑剂的浓度对贴片的形成和分离特性至关重要。为了在保质期内用作增塑剂和溶解性增强剂，选择了吐温 80。配方 F-5 已针对所需的质量进行了优化，是一批有效的配方。
{"title":"Formulate and evaluate transdermal patches using Econazole","authors":"Archana B, Sri Chaya Reddy Konda, Amulya Shreshta Gadapati, Sadiq Abubakar","doi":"10.26452/fjphs.v4i2.608","DOIUrl":"https://doi.org/10.26452/fjphs.v4i2.608","url":null,"abstract":"The current project aims to formulate and evaluate econazole-based transdermal patches. At present, the market offers econazole tablets for purchase. These dose formulations do not elicit cooperation from patients. Therefore, because transdermal drug administration systems are simple to use and improve patient compliance, they have begun to gain momentum as innovative drug delivery methods. The research aims to use polymers like HPMC K 15M, HPMC K 100M, and HPMC K200M to build and evaluate econazole transdermal patches. The solvent casting technique for making econazole transdermal patches. To determine the formulation's approximate drug content, an appropriate in vitro technique is employed to investigate the drug release pattern. To delay the drug's release over a long period. To develop a dose form that prevents patient compliance and reduces dosage frequency for optimal drug utilization. Tween 80 plasticizer concentration was essential for patch creation and separation characteristics. For use as a plasticizer and solubility enhancer during the shelf life term, Tween 80 is chosen. The formulation F-5 was optimized for the desired qualities and was an effective batch.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"18 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present work is to prepare anti-cancer drugs through In – Silico Biological Evaluation using SWISS ADME. The new Swiss ADME web tool, which includes in-house expert methods like the BOILED-Egg, Ilogp, and Bioavailability Radar, provides free access to a pool of quick yet reliable predictive models for physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry friendliness. It is developed to predict various pharmacodynamics and pharmacokinetics properties of small molecules, helping researchers in the drug discovery and development process. Researchers can use this tool to assess the potential success of a drug in terms of its ADME. Swiss ADME offers predictive model for various pharmacokinetic properties such as solubility, lipophilicity, and bioavailability this helps researchers assess how a drug candidate will be absorbed, distributed, metabolized, and excreted in the body.
{"title":"In – Silico Biological Evaluation of Anticancer Drugs - SWISS ADME","authors":"Nizamuddin Nd, Roopa D, Pramodini Alla, Afshin Shams Shaik, Vamshi Kumar Achari P, Sudhakar Reddy Kapu","doi":"10.26452/fjphs.v4i2.604","DOIUrl":"https://doi.org/10.26452/fjphs.v4i2.604","url":null,"abstract":"The aim of the present work is to prepare anti-cancer drugs through In – Silico Biological Evaluation using SWISS ADME. The new Swiss ADME web tool, which includes in-house expert methods like the BOILED-Egg, Ilogp, and Bioavailability Radar, provides free access to a pool of quick yet reliable predictive models for physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry friendliness. It is developed to predict various pharmacodynamics and pharmacokinetics properties of small molecules, helping researchers in the drug discovery and development process. Researchers can use this tool to assess the potential success of a drug in terms of its ADME. Swiss ADME offers predictive model for various pharmacokinetic properties such as solubility, lipophilicity, and bioavailability this helps researchers assess how a drug candidate will be absorbed, distributed, metabolized, and excreted in the body.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140688479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural (guar gum) super disintegrating agent increases the rate of dissolution as well as length of disintegration of fast-dissolving tablets. In vitro drug release of 96% is demonstrated in 6 minutes with a disintegrating efficiency of 27 seconds for Nifedipine FDTs (guar gum). Consequently, our study has shown that formulations made with a natural super disintegrating agent exhibit shorter disintegration times as well as higher rates of dissolution along with drug release.
{"title":"Formulation and evaluation of nifedipine fast dissolving tablets","authors":"Syam Sundar Gurram, Nagaveni P, Sreevalli Arigela","doi":"10.26452/fjphs.v4i2.599","DOIUrl":"https://doi.org/10.26452/fjphs.v4i2.599","url":null,"abstract":"The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural (guar gum) super disintegrating agent increases the rate of dissolution as well as length of disintegration of fast-dissolving tablets. In vitro drug release of 96% is demonstrated in 6 minutes with a disintegrating efficiency of 27 seconds for Nifedipine FDTs (guar gum). Consequently, our study has shown that formulations made with a natural super disintegrating agent exhibit shorter disintegration times as well as higher rates of dissolution along with drug release.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"122 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khaja Moinuddin Shaik, Pradeep Kumar M, Jagadeesh Babu B, Manjula C
The current study aimed to develop hydrocortisone mucoadhesive microbeads to prolong the drug's action in the gastrointestinal system, targeting Crohn's disease treatment. Hydrocortisone, known for its anti-inflammatory and anti-rheumatic effects, was utilized in bead form to enhance therapeutic efficacy, extend residence time, and reduce dosage frequency. Using sodium alginate, HPMC, and Eudragit L-100 as adhesive polymers, and calcium chloride and aluminium chloride as cross-linking agents, the study crafted microbeads with an entrapment efficiency between 57.23% and 91.69%. Evaluations focused on in vitro drug release, particle size, surface characteristics, entrapment efficiency, and the role of cross-linking ions. Of the formulations, HCS-8 (with sodium alginate and Eudragit L-100 using aluminium chloride as the gelling solution) and HCS-2 showed optimal drug release profiles. Notably, HCS-8 achieved a 12-hour drug release delay, attributed to aluminium chloride's cross-linking action. Drug release kinetics revealed a zero-order linearity (R2=0.99), suggesting super case 2 transport as the primary release mechanism.
{"title":"Formulation and evaluation of hydrocortisone micro beads","authors":"Khaja Moinuddin Shaik, Pradeep Kumar M, Jagadeesh Babu B, Manjula C","doi":"10.26452/fjphs.v4i2.591","DOIUrl":"https://doi.org/10.26452/fjphs.v4i2.591","url":null,"abstract":"The current study aimed to develop hydrocortisone mucoadhesive microbeads to prolong the drug's action in the gastrointestinal system, targeting Crohn's disease treatment. Hydrocortisone, known for its anti-inflammatory and anti-rheumatic effects, was utilized in bead form to enhance therapeutic efficacy, extend residence time, and reduce dosage frequency. Using sodium alginate, HPMC, and Eudragit L-100 as adhesive polymers, and calcium chloride and aluminium chloride as cross-linking agents, the study crafted microbeads with an entrapment efficiency between 57.23% and 91.69%. Evaluations focused on in vitro drug release, particle size, surface characteristics, entrapment efficiency, and the role of cross-linking ions. Of the formulations, HCS-8 (with sodium alginate and Eudragit L-100 using aluminium chloride as the gelling solution) and HCS-2 showed optimal drug release profiles. Notably, HCS-8 achieved a 12-hour drug release delay, attributed to aluminium chloride's cross-linking action. Drug release kinetics revealed a zero-order linearity (R2=0.99), suggesting super case 2 transport as the primary release mechanism.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"36 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The current study focuses on the formulation, development, and in vitro testing of pologlitazone microspheres containing guar gum and chitosan as naturally occurring polysaccharides that delay release. Nine formulations were created by altering the chitosan and guar gum ratios, using span-85 as an emulsifier as well as glutaraldehyde as a chemical cross linking agent. The microspheres were assessed in terms of particle size, encapsulation effectiveness, drug loading capacity, and in vitro drug release tests. The average particle size ranged from 30.2 mm (PP 1) to 36.5 mm (PP 2). There was a range of 0.45 to 0.78 in the swelling index. Microspheres smooth surfaces were found by SEM investigation. In order to verify that there are no chemical interactions between the medication and the polymer and to understand the structure of microspheres, differential scanning calorimetry as well as Fourier transform infrared spectroscopy were employed. At 10 hours, the optimised batch PP 1 released 97.45% using phosphate buffer pH7.4 as a dissolving media. In terms of release kinetics, the optimised formula's data were best fitted with the Higuchi model (r2= 0.671) and demonstrated zero order release (r2= 0.980) via a non-Fickian diffusion mechanism.
{"title":"Formulation and evaluation of pioglitazone microspheres","authors":"Rajagopal Rajaguru","doi":"10.26452/fjphs.v4i2.592","DOIUrl":"https://doi.org/10.26452/fjphs.v4i2.592","url":null,"abstract":"The current study focuses on the formulation, development, and in vitro testing of pologlitazone microspheres containing guar gum and chitosan as naturally occurring polysaccharides that delay release. Nine formulations were created by altering the chitosan and guar gum ratios, using span-85 as an emulsifier as well as glutaraldehyde as a chemical cross linking agent. The microspheres were assessed in terms of particle size, encapsulation effectiveness, drug loading capacity, and in vitro drug release tests. The average particle size ranged from 30.2 mm (PP 1) to 36.5 mm (PP 2). There was a range of 0.45 to 0.78 in the swelling index. Microspheres smooth surfaces were found by SEM investigation. In order to verify that there are no chemical interactions between the medication and the polymer and to understand the structure of microspheres, differential scanning calorimetry as well as Fourier transform infrared spectroscopy were employed. At 10 hours, the optimised batch PP 1 released 97.45% using phosphate buffer pH7.4 as a dissolving media. In terms of release kinetics, the optimised formula's data were best fitted with the Higuchi model (r2= 0.671) and demonstrated zero order release (r2= 0.980) via a non-Fickian diffusion mechanism.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"35 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nagashubha Bobbarjang, Praveena Kasi, Charitha Bandlapalli, Madhu Repollu Maddileti, Padmanabha Reddy Y, Kiran Sai Maccha
Delivering drugs to tumour or defective cells effectively and efficiently while minimizing harmful side effects is one of the biggest issues facing the medical field. In order to address this issue, the pharmaceutical industry has developed a number of drug carriers that aid in getting the therapeutic medication or gene to the intended location. It has been discovered that mesoporous silica nanoparticles are biocompatible, chemically and thermally stable nanoparticles for this purpose the amount of research on MSNs has increased significantly in the last few years. Since 2001, when MCM-41 was first suggested as a drug carrier for a controlled delivery system, followed by SBA-15 and MCM-48. When changed, morphological features like pore size, pore volume, particle size, surface area, pH, and drug loading capacity have a significant impact on MSNs. Drug distribution to the intended place is elaborated by functionalizing MSNs with organic and inorganic groups. The most recent studies on MSN synthesis techniques and its uses in medical imaging, diagnostics, cellular uptake, target medication administration, cell tracing, and biosensing are also included in this review article.
{"title":"Targeted drug delivery to the lungs using mesoporous silica nanoparticles","authors":"Nagashubha Bobbarjang, Praveena Kasi, Charitha Bandlapalli, Madhu Repollu Maddileti, Padmanabha Reddy Y, Kiran Sai Maccha","doi":"10.26452/fjphs.v4i2.589","DOIUrl":"https://doi.org/10.26452/fjphs.v4i2.589","url":null,"abstract":"Delivering drugs to tumour or defective cells effectively and efficiently while minimizing harmful side effects is one of the biggest issues facing the medical field. In order to address this issue, the pharmaceutical industry has developed a number of drug carriers that aid in getting the therapeutic medication or gene to the intended location. It has been discovered that mesoporous silica nanoparticles are biocompatible, chemically and thermally stable nanoparticles for this purpose the amount of research on MSNs has increased significantly in the last few years. Since 2001, when MCM-41 was first suggested as a drug carrier for a controlled delivery system, followed by SBA-15 and MCM-48. When changed, morphological features like pore size, pore volume, particle size, surface area, pH, and drug loading capacity have a significant impact on MSNs. Drug distribution to the intended place is elaborated by functionalizing MSNs with organic and inorganic groups. The most recent studies on MSN synthesis techniques and its uses in medical imaging, diagnostics, cellular uptake, target medication administration, cell tracing, and biosensing are also included in this review article.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"83 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronotherapy, the delivery of drugs in accordance with the body's circadian cycle, has become a promising strategy to increase the effectiveness and lower the toxicity of cancer treatment. Cell division, DNA repair, and metabolism are three physiological functions regulated by the circadian clock that are known to affect how well anti-cancer treatments work. This study reviews the present status of research on timing techniques in order to offer a thorough overview of chronotherapy in the treatment of cancer. The review starts off by going over the basic ideas of circadian rhythms and how they relate to cancer biology. The justification for adopting chronotherapy to improve treatment results is then discussed, including the possibility of increasing therapeutic efficacy while reducing side effects. A full analysis of preclinical research is then provided, emphasizing the influence of treatment scheduling on drug metabolism, host-tumor interactions, and tumor growth inhibition. The significance of taking circadian rhythms into account while developing cancer treatment plans is emphasized in this study. The complicated interactions between circadian biology, tumor dynamics, and treatment effects are highlighted, underscoring the need for more study. In the end, utilizing the power of chronotherapy has the potential to transform cancer treatment by customizing regimens based on each patient's inherent rhythms.
{"title":"Chronotherapy for Cancer Treatment: A Review of Timing Strategies","authors":"Bharathi Arigela, Nookaraju S, R. D","doi":"10.26452/fjphs.v4i1.588","DOIUrl":"https://doi.org/10.26452/fjphs.v4i1.588","url":null,"abstract":"Chronotherapy, the delivery of drugs in accordance with the body's circadian cycle, has become a promising strategy to increase the effectiveness and lower the toxicity of cancer treatment. Cell division, DNA repair, and metabolism are three physiological functions regulated by the circadian clock that are known to affect how well anti-cancer treatments work. This study reviews the present status of research on timing techniques in order to offer a thorough overview of chronotherapy in the treatment of cancer. The review starts off by going over the basic ideas of circadian rhythms and how they relate to cancer biology. The justification for adopting chronotherapy to improve treatment results is then discussed, including the possibility of increasing therapeutic efficacy while reducing side effects. A full analysis of preclinical research is then provided, emphasizing the influence of treatment scheduling on drug metabolism, host-tumor interactions, and tumor growth inhibition. The significance of taking circadian rhythms into account while developing cancer treatment plans is emphasized in this study. The complicated interactions between circadian biology, tumor dynamics, and treatment effects are highlighted, underscoring the need for more study. In the end, utilizing the power of chronotherapy has the potential to transform cancer treatment by customizing regimens based on each patient's inherent rhythms.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"60 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Moxifloxacin, a fourth-generation broad-spectrum antibiotic, is at the heart of this research, aimed at treating infective ophthalmitis through sustained release via ion-sensitive ocular in-situ gels. The study emphasizes the importance of careful polymer and drug selection for effective oral in-situ gel formulation. Sodium alginate and HPMC were identified as compatible polymers with Moxifloxacin, as confirmed by IR and UV analyses. The concentration of these polymers significantly influences the gel's viscosity, spreadability, and drug release properties. Among the tested formulations, F4 emerged as superior, exhibiting the highest drug release and favorable rheological properties. This formulation not only showed good stability and uniformity but also resulted in better and faster patient improvement. Although the current results are promising, further pharmacokinetic studies are suggested. The F4 formulation outperformed others in efficacy, making it the most optimal choice. In vitro release studies validated the effectiveness of the Moxifloxacin gel formulations used in this research. The extended drug delivery system developed here has the potential to enhance the bioavailability of the medication, thereby improving patient efficacy, compliance, and overall therapeutic value.
{"title":"Formulation and evaluation of moxifloxacin loaded ocular In-situ gels","authors":"Sirisha Velchuri, Ram Babu P, Sandeep Kumar G, Revathi Sarvepalli","doi":"10.26452/fjphs.v4i1.559","DOIUrl":"https://doi.org/10.26452/fjphs.v4i1.559","url":null,"abstract":"Moxifloxacin, a fourth-generation broad-spectrum antibiotic, is at the heart of this research, aimed at treating infective ophthalmitis through sustained release via ion-sensitive ocular in-situ gels. The study emphasizes the importance of careful polymer and drug selection for effective oral in-situ gel formulation. Sodium alginate and HPMC were identified as compatible polymers with Moxifloxacin, as confirmed by IR and UV analyses. The concentration of these polymers significantly influences the gel's viscosity, spreadability, and drug release properties. Among the tested formulations, F4 emerged as superior, exhibiting the highest drug release and favorable rheological properties. This formulation not only showed good stability and uniformity but also resulted in better and faster patient improvement. Although the current results are promising, further pharmacokinetic studies are suggested. The F4 formulation outperformed others in efficacy, making it the most optimal choice. In vitro release studies validated the effectiveness of the Moxifloxacin gel formulations used in this research. The extended drug delivery system developed here has the potential to enhance the bioavailability of the medication, thereby improving patient efficacy, compliance, and overall therapeutic value.","PeriodicalId":503124,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"271 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140491054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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