Pub Date : 2026-01-01DOI: 10.25259/IJDVL_1060_2024
Kaya L Curtis, Onajia Stubblefield, Brieann Sobieski, Shari R Lipner
{"title":"Lichen sclerosus is associated with genital herpes simplex virus infection in a case-control study of 6,150 participants.","authors":"Kaya L Curtis, Onajia Stubblefield, Brieann Sobieski, Shari R Lipner","doi":"10.25259/IJDVL_1060_2024","DOIUrl":"10.25259/IJDVL_1060_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"117-119"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Grandmother's remedies vs. modern dermatology: Can traditional wisdom still help?","authors":"Sharang Gupta","doi":"10.25259/IJDVL_356_2025","DOIUrl":"10.25259/IJDVL_356_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"137-138"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.25259/IJDVL_2269_2025
Archana Singal
{"title":"Reflecting on three years as IJDVL editor.","authors":"Archana Singal","doi":"10.25259/IJDVL_2269_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_2269_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"92 1","pages":"1-3"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Upadacitinib, a second-generation oral Janus kinase (JAK) inhibitor, selectively targets the JAK 1 non-receptor protein kinase, effectively modulating downstream inflammatory pathways implicated in a range of dermatological diseases. Its JAK 1 selectivity mitigates unwanted side effects associated with broader JAK inhibition. FDA approval for moderate to severe atopic dermatitis (AD) in January 2022 marked a significant milestone, expanding treatment options in dermatology. Since then, upadacitinib has demonstrated efficacy in various dermatological disorders, contributing to improved patient outcomes. This review aims to spotlight its use in AD, as well as off-label indications in dermatology, its safety and efficacy profile, and pertinent information regarding side effects and contraindications.
{"title":"Upadacitinib in dermatology: A systematic review of mechanism, current applications, efficacy, safety, and emerging evidence.","authors":"Sunil Dogra, Thammannagowda Prarthana, Gaikwad Sudharani, Seema Chhabra","doi":"10.25259/IJDVL_133_2025","DOIUrl":"10.25259/IJDVL_133_2025","url":null,"abstract":"<p><p>Upadacitinib, a second-generation oral Janus kinase (JAK) inhibitor, selectively targets the JAK 1 non-receptor protein kinase, effectively modulating downstream inflammatory pathways implicated in a range of dermatological diseases. Its JAK 1 selectivity mitigates unwanted side effects associated with broader JAK inhibition. FDA approval for moderate to severe atopic dermatitis (AD) in January 2022 marked a significant milestone, expanding treatment options in dermatology. Since then, upadacitinib has demonstrated efficacy in various dermatological disorders, contributing to improved patient outcomes. This review aims to spotlight its use in AD, as well as off-label indications in dermatology, its safety and efficacy profile, and pertinent information regarding side effects and contraindications.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"92 1","pages":"68-76"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.25259/IJDVL_1807_2024
Akriti Agrawal, Sivaranjini Ramassamy
{"title":"Fractional CO2-assisted topical delivery of tofacitinib as an effective modality for refractory nail psoriasis.","authors":"Akriti Agrawal, Sivaranjini Ramassamy","doi":"10.25259/IJDVL_1807_2024","DOIUrl":"10.25259/IJDVL_1807_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"106-108"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sushant Agrawal, Ananya Sharma, M Ramam, Sujay Khandpur, Binod K Khaitan, Ashish Datt Upadhyay, Vishal Gupta
Background Dermoscopy can potentially obviate the need for skin biopsy, particularly at cosmetically sensitive sites such as the face. While dermoscopic features of various skin diseases are well described, information on dermoscopic findings in normal skin is limited. Objectives To study the dermoscopic features of the normal face. Methods Two-hundred subjects without any facial skin disease were included in the study. Dermoscopic findings of different facial sites (forehead, bilateral zygomatic areas, bilateral cheeks, nose and chin) were evaluated using a hand-held dermoscope (Heine Delta 30) by two investigators. Dermoscopic differences between different facial sites, gender and age groups were compared. Results Most (n=156, 78%) subjects had Fitzpatrick skin type IV-VI. A background pseudonetwork was present in a majority at all the sites, except the nose (62-85% vs 41%, p<0.001). An accentuated patchy pseudonetwork was seen most commonly on the cheeks and zygoma (18-21%, p<0.001). Follicles were of uniform size and present at uniform distances in a majority at all sites, but were more commonly variable on the nose (53-70%, p<0.001). Follicular brown pigmentation was seen in 27-37% at all sites, except the forehead (9%, p<0.001). Brown circles around adnexal openings were seen most commonly on the nose (41%, p< .001). A 'dot in circle' morphology was seen most commonly on the zygoma and cheeks (25-30%, p<0.001). Vessels were more commonly seen on the cheeks (48%) and chin (27%) as compared to other sites (p<0.001). The most common vessel pattern was a linear, non-branching one. Focussed or dotted vessels were not seen at any site. White reticular lines were seen almost exclusively on the nose (15%, p<0.001). Accentuated patchy pseudonetwork, follicular plugs and brown circles around adnexal openings were more common in males, while follicular brown pigmentation was statistically significantly more common in females. Accentuated patchy pseudonetwork, follicular plugs, follicular brown pigmentation, brown circles around adnexal openings, vessels, and reticular white lines became more common with advancing age. Limitations Relatively small sample size, smaller proportion of elderly subjects, and a majority of the subjects belonging to darker skin phototypes (V-VI) Conclusion Knowledge of variations in normal dermoscopic findings of the face will help dermatologists in distinguishing abnormal from normal, and improve the interpretation of dermoscopic findings of facial skin lesions.
皮肤镜检查可以潜在地避免皮肤活检的需要，特别是在美容敏感部位，如脸部。虽然各种皮肤病的皮肤镜特征被很好地描述，但正常皮肤的皮肤镜发现的信息是有限的。目的研究正常面部的皮肤镜特征。方法选取200例无面部皮肤病的受试者作为研究对象。两位研究者使用手持式皮肤镜（Heine Delta 30）对不同面部部位（前额、双侧颧骨区域、双侧脸颊、鼻子和下巴）的皮肤镜检查结果进行了评估。比较不同面部部位、性别和年龄组的皮肤镜差异。结果大多数（n= 156,78 %）受试者为IV-VI型Fitzpatrick皮肤。背景伪网络在所有站点中都占多数，除了鼻子(62-85% vs 41%, p
{"title":"Mapping the dermoscopic features of the normal face: Findings from 200 subjects with skin of colour.","authors":"Sushant Agrawal, Ananya Sharma, M Ramam, Sujay Khandpur, Binod K Khaitan, Ashish Datt Upadhyay, Vishal Gupta","doi":"10.25259/IJDVL_107_2025","DOIUrl":"10.25259/IJDVL_107_2025","url":null,"abstract":"<p><p>Background Dermoscopy can potentially obviate the need for skin biopsy, particularly at cosmetically sensitive sites such as the face. While dermoscopic features of various skin diseases are well described, information on dermoscopic findings in normal skin is limited. Objectives To study the dermoscopic features of the normal face. Methods Two-hundred subjects without any facial skin disease were included in the study. Dermoscopic findings of different facial sites (forehead, bilateral zygomatic areas, bilateral cheeks, nose and chin) were evaluated using a hand-held dermoscope (Heine Delta 30) by two investigators. Dermoscopic differences between different facial sites, gender and age groups were compared. Results Most (n=156, 78%) subjects had Fitzpatrick skin type IV-VI. A background pseudonetwork was present in a majority at all the sites, except the nose (62-85% vs 41%, p<0.001). An accentuated patchy pseudonetwork was seen most commonly on the cheeks and zygoma (18-21%, p<0.001). Follicles were of uniform size and present at uniform distances in a majority at all sites, but were more commonly variable on the nose (53-70%, p<0.001). Follicular brown pigmentation was seen in 27-37% at all sites, except the forehead (9%, p<0.001). Brown circles around adnexal openings were seen most commonly on the nose (41%, p< .001). A 'dot in circle' morphology was seen most commonly on the zygoma and cheeks (25-30%, p<0.001). Vessels were more commonly seen on the cheeks (48%) and chin (27%) as compared to other sites (p<0.001). The most common vessel pattern was a linear, non-branching one. Focussed or dotted vessels were not seen at any site. White reticular lines were seen almost exclusively on the nose (15%, p<0.001). Accentuated patchy pseudonetwork, follicular plugs and brown circles around adnexal openings were more common in males, while follicular brown pigmentation was statistically significantly more common in females. Accentuated patchy pseudonetwork, follicular plugs, follicular brown pigmentation, brown circles around adnexal openings, vessels, and reticular white lines became more common with advancing age. Limitations Relatively small sample size, smaller proportion of elderly subjects, and a majority of the subjects belonging to darker skin phototypes (V-VI) Conclusion Knowledge of variations in normal dermoscopic findings of the face will help dermatologists in distinguishing abnormal from normal, and improve the interpretation of dermoscopic findings of facial skin lesions.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"6-13"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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