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Optimising the tumour elimination payoff in cancer therapy 优化癌症治疗中的肿瘤消除回报
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-23 DOI: 10.1049/cth2.12701
Nigel J. Burroughs, Mathilde L. C. Leuridan

A new payoff function is proposed for cancer treatment optimisation, the tumour elimination payoff (TEP), that incorporates the increase in lifespan if tumour elimination is achieved. The TEP is discounted by drug toxicity and by potential risks, such as metastasis and mutation. An approximation is used for the probability of tumour elimination, eαN(T)$e^{-alpha N(T)}$, giving a terminal payoff with an exponential dependence on the final tumour size N(T)$N(T)$. The optimal solutions for this payoff for simple tumour growth models, (logistic and Gompertz growth), are determined. Using Pontryagin's maximum principle it is proved that bang–bang optimal solutions exist with a single switch; specifically delayed treatment and treat-and-stop solutions at maximum tolerated dose (MTD) exist. There is also a singular arc with constant tumour size. Solutions either have a high probability, respectively, low probability of tumour elimination; these correspond to a post-treatment high probability of cure, and a high probability of relapse, respectively. Optimising over the time horizon T$T$ results in solutions that are either MTD throughout or no treatment, that is, treatment is either beneficial or detrimental. For the logistic growth model, the treatment benefit phase diagram is derived with respect to the patient's expected increase in lifespan and tumour size.

针对癌症治疗优化提出了一种新的回报函数--肿瘤消除回报(TEP),它包含了实现肿瘤消除后寿命的延长。TEP 会因药物毒性以及转移和突变等潜在风险而打折扣。肿瘤消除概率采用近似值 e - α N ( T ) $e^{-αN(T)}$,得出的最终报酬与最终肿瘤大小 N ( T ) $N(T)$呈指数关系。针对简单的肿瘤生长模型(逻辑生长和贡培兹生长),确定了这种报酬的最优解。利用庞特里亚金的最大值原理,证明了 "砰砰 "最优解存在于单一开关中;特别是存在最大耐受剂量(MTD)下的延迟治疗和治疗-停止解。此外,还存在肿瘤大小不变的奇异弧。这些方案分别对应于治疗后治愈的高概率和复发的高概率。在时间跨度 T $T$ 上进行优化的结果是,解决方案要么是全程 MTD,要么是不治疗,也就是说,治疗要么是有益的,要么是有害的。对于逻辑增长模型,可以根据患者预期寿命的延长和肿瘤的大小推导出治疗获益阶段图。
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引用次数: 0
Enhanced precision in robot arm positioning: A nonlinear damping approach for flexible joint manipulators 提高机械臂定位精度:柔性关节机械手的非线性阻尼方法
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-22 DOI: 10.1049/cth2.12707
Amir Hossein Jafari, Rached Dhaouadi, Reza Jafari

This article introduces an advanced nonlinear controller designed for optimizing the performance of a single-link robot arm featuring a flexible joint. The proposed nonlinear control strategy incorporates a Proportional-Integral (PI) controller in conjunction with a nonlinear velocity feedback component, aimed at providing effective nonlinear damping and suppressing vibrations. To validate the controller's performance, extensive simulations are conducted utilizing machine learning techniques within the Python environment. The performance of the proposed nonlinear damping controller is benchmarked against a conventional linear cascaded P-PI control structure, with both controllers fine-tuned using the Nelder-Mead algorithm. Simulation results demonstrate that the nonlinear damping controller yields substantial improvements in the dynamic behavior of the robot axis arm, showcasing superior step and sinusoidal position tracking performance, along with active vibration damping capabilities. This research contributes valuable insights into the enhanced nonlinear control strategies for flexible-joint robot arms, offering promising advancements in their overall dynamic performance.

本文介绍了一种先进的非线性控制器,旨在优化具有柔性关节的单链机械臂的性能。所提出的非线性控制策略结合了比例-积分(PI)控制器和非线性速度反馈组件,旨在提供有效的非线性阻尼和抑制振动。为了验证控制器的性能,我们在 Python 环境中利用机器学习技术进行了大量仿真。提出的非线性阻尼控制器的性能以传统的线性级联 P-PI 控制结构为基准,两个控制器均使用 Nelder-Mead 算法进行微调。仿真结果表明,非线性阻尼控制器大大改善了机器人轴臂的动态性能,展示了卓越的阶跃和正弦位置跟踪性能,以及主动减振能力。这项研究为柔性关节机械臂的增强型非线性控制策略提供了宝贵的见解,有望提高机械臂的整体动态性能。
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引用次数: 0
Hysteresis based predictive torque control without weighting factors for induction motor drives 基于磁滞的预测转矩控制,不含感应电机驱动器的权重系数
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-21 DOI: 10.1049/cth2.12681
Muhammad Bilal Shahid, Weidong Jin, Muhammad Abbas Abbasi, Abdul Rashid Husain, Abdul Rauf Bhatti, Akhtar Rasool, Syed Md. Galib

This work proposes a weighting-factor-free finite control set predictive torque control (FCS-PTC) for induction motor drives by incorporating a hysteresis controller to eliminate stator flux error from the cost function. The tuning of the weighting factor coefficient in FCS-PTC is critical for improved drive performance. Conventionally, the tuning is based on an intuitive understanding of the dynamical system and empirical methods, which may not yield optimal results. The proposed method regulates the flux by incorporating a separate two-level hysteresis controller and torque by the conventional cost function-based PTC. The cost function uses torque error only and employs a reduced number of voltage vectors. The reduction of voltage vectors is obtained through the flux hysteresis output and sector determination. The proposed work is implemented experimentally on the dSpace DS1104 controller board for a two-level three, three-phase voltage source inverter-fed induction motor drive. The experimental results validate the effectiveness of the proposed work under different drive tests compared to conventional PTC and direct torque control (DTC). The obtained results show comparable dynamic performance of the drive with 43%$43%$ lower computational burden than conventional PTC. Along with computational benefit, the proposed work demonstrates improved total harmonic distortion (THD) at low-speed regions due to the absence of a weighting factor in the cost function.

本文提出了一种无权重因子有限控制集预测转矩控制(FCS-PTC),用于异步电机驱动,通过结合磁滞控制器来消除成本函数中的定子磁链误差。FCS-PTC中权重因子系数的调整对提高驱动性能至关重要。通常,调整是基于对动力系统和经验方法的直观理解,这可能不会产生最佳结果。该方法通过结合一个单独的两级磁滞控制器和传统的基于成本函数的PTC的转矩来调节磁链。成本函数仅使用转矩误差,并使用减少数量的电压矢量。电压矢量的减小是通过磁链迟滞输出和扇区确定来实现的。所提出的工作在dSpace DS1104控制器板上实验实现,用于二电平三三相电压源逆变式感应电机驱动。实验结果表明,与传统的PTC和直接转矩控制(DTC)相比,该方法在不同的驱动测试下是有效的。所得结果表明,该驱动器的动态性能与传统PTC相当,计算负担比传统PTC低43%。除了计算效益外,由于成本函数中没有加权因子,所提出的工作证明了低速区域的总谐波失真(THD)得到改善。
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引用次数: 0
Coordinated finite-time control of multiple motors with saturation constraints 带饱和约束的多电机有限时间协调控制
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-20 DOI: 10.1049/cth2.12684
Changfan Zhang, Junming Zhang, Jing He, Lin Jia, Yang Zhou

A multi-motor coordinated tracking control strategy based on a disturbance sliding-mode observer and an anti-saturation non-singular fast-terminal sliding mode is proposed to address the issues of slow convergence and controller output saturation in multi-motor coordinated control systems. Firstly, a mathematical model of a multi-motor traction system considering uncertain parameter perturbations, external disturbances, and dead zones was established. Secondly, a disturbance sliding-mode observer was designed based on the mathematical model to eliminate motor disturbances and estimate the torque. The observer's forward compensation was added to design a total-consensus-based fast non-singular terminal sliding-mode controller. Then, a fast anti-saturation auxiliary system with fast finite-time convergence was constructed. Finally, a comparative experiment was conducted with traditional anti-saturation sliding-mode control to demonstrate that the proposed method had faster convergence, stronger disturbance rejection, and better tracking performance in the presence of multi-motor parameter perturbations, unknown disturbances, and input saturation.

针对多电机协调控制系统中收敛速度慢和控制器输出饱和的问题,提出了一种基于扰动滑模观测器和抗饱和非鞘翅式快速终端滑模的多电机协调跟踪控制策略。首先,建立了考虑不确定参数扰动、外部干扰和死区的多电机牵引系统数学模型。其次,根据数学模型设计了扰动滑模观测器,以消除电机扰动并估计转矩。观测器的正向补偿被添加到设计基于总共识的快速非矢量终端滑模控制器中。然后,构建了具有快速有限时间收敛性的快速抗饱和辅助系统。最后,与传统的抗饱和滑模控制进行了对比实验,证明在多电机参数扰动、未知干扰和输入饱和的情况下,所提出的方法具有更快的收敛速度、更强的干扰抑制能力和更好的跟踪性能。
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引用次数: 0
Reinforcement learning-based finite-time cross-media tracking control for a cross-media vehicle under unknown dynamics and disturbances 未知动态和干扰条件下基于强化学习的跨媒体车辆有限时间跨媒体跟踪控制
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-18 DOI: 10.1049/cth2.12693
Shichong Wu, Lingli Xie, Jun Xian, Fei Liao, Wenhua Wu, Mingqing Lu, Xian Yi

This study proposes a reinforcement learning-based finite-time cross-media tracking control approach for a slender body cross-media vehicle encountering unknown hydrodynamics, wind, and wave disturbances. Initially, a reinforcement learning framework consisting of the actor neural network and critic neural network is constructed. The critic neural network monitors the actions of the actor neural network and approximates the cost function, while the actor neural network estimates the unknown hydrodynamics and disturbances, minimising the cost function to optimise performance. Subsequently, the command filter featuring finite-time convergence is formulated, effectively managing the corresponding filter error through a proposed error compensating signal. By integrating these techniques, a reinforcement learning-based finite-time control strategy is developed, circumventing the singularity issue inherent in traditional finite-time backstepping strategies. Comparative analysis with existing methods demonstrates the strong robustness of the proposed scheme against unknown hydrodynamics and disturbances, ensuring finite-time convergence of the system's states and optimising controller performance. Finally, simulations confirm the effectiveness and superiority of the presented approach.

本研究提出了一种基于强化学习的有限时间跨媒体跟踪控制方法,适用于遇到未知流体力学、风和波浪干扰的细长体跨媒体飞行器。首先,构建了一个由行动者神经网络和批评者神经网络组成的强化学习框架。批判者神经网络监控行动者神经网络的行动并逼近成本函数,而行动者神经网络则估计未知的流体力学和干扰,最小化成本函数以优化性能。随后,制定了以有限时间收敛为特征的指令滤波器,通过建议的误差补偿信号有效管理相应的滤波器误差。通过整合这些技术,开发出了基于强化学习的有限时间控制策略,规避了传统有限时间反步进策略固有的奇异性问题。与现有方法的对比分析表明,所提出的方案对未知流体力学和干扰具有很强的鲁棒性,可确保系统状态的有限时间收敛并优化控制器性能。最后,模拟证实了所提出方法的有效性和优越性。
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引用次数: 0
Finite-time control for a quadcopter UAV in the application of wildfire monitoring 四旋翼无人飞行器的有限时间控制在野火监测中的应用
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-17 DOI: 10.1049/cth2.12696
Joewell Mawanza, John Agee, Ernest Bhero

This article investigates the problem of monitoring wildfires using a quadcopter uncrewed aerial vehicle (UAV) subject to external perturbations and nonlinear uncertainties. A finite-time control scheme is designed for the quadcopter UAV to monitor the elliptical propagation of a wildfire. The control scheme is composed of an improved nonsingular fast terminal sliding mode control (NFTSMC) and a higher order sliding mode observer (HOSMO). The HOSMO is constructed first to estimate external perturbations, nonlinear uncertainties, and incomplete system states resulting from the system's uncertainties. Then, a novel NFTSMC is developed that utilizes the estimated system states. The Lyapunov theorem is used to demonstrate that the quadcopter UAV can elliptically monitor a wildfire, and the tracking error can rapidly converge to zero within a finite time. Comparative simulation results are presented to illustrate the effectiveness of the proposed control scheme.

本文研究了使用四旋翼无人飞行器(UAV)监测野火的问题,该飞行器受到外部扰动和非线性不确定性的影响。本文为四旋翼无人飞行器设计了一种有限时间控制方案,用于监测野火的椭圆形传播。该控制方案由改进的非奇异快速终端滑模控制(NFTSMC)和高阶滑模观测器(HOSMO)组成。HOSMO 首先用于估计外部扰动、非线性不确定性以及系统不确定性导致的不完整系统状态。然后,利用估计的系统状态开发出一种新型 NFTSMC。利用 Lyapunov 定理证明了四旋翼无人机可以椭圆监测野火,并且跟踪误差可以在有限的时间内迅速收敛为零。仿真结果对比说明了所提控制方案的有效性。
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引用次数: 0
Attack detection method for encrypted wave-variable-based bilateral control systems 基于加密波变量的双边控制系统的攻击检测方法
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-17 DOI: 10.1049/cth2.12697
Tetsuro Miyazaki, Naoto Shono, Kaoru Teranishi, Takahiro Kanno, Toshihiro Kawase, Kiminao Kogiso, Kenji Kawashima

This study presents an energy-based attack detection method involving an encrypted bilateral control system using wave variables. In the considered bilateral control system, the leader and follower receive the follower's force information and the leader's velocity information, respectively, through the wave variables. The considered attack model multiplies the wave variables by an attack parameter, which is possible due to the malleability of the encryption scheme. The bilateral control system will be destabilized if the attacker chooses a relatively large parameter value. This motivates in developing a passivity observer for each leader and follower side to compute the total energy and constructing an energy-based detection method that can be incorporated into the encrypted bilateral control system and is summarized in the presented theorem. Furthermore, this study provides a specific design for reasonable threshold parameters concerning the control system energy. The theorem and the experimental validation confirm that the developed encrypted wave-variable-based bilateral control system with the proposed attack detector is secure and effective as a countermeasure against malleability-based attacks.

本研究提出了一种基于能量的攻击检测方法,涉及使用波变量的加密双边控制系统。在所考虑的双边控制系统中,领导者和跟随者分别通过波形变量接收跟随者的力信息和领导者的速度信息。所考虑的攻击模型将波形变量乘以一个攻击参数,由于加密方案的延展性,这种攻击是可能的。如果攻击者选择一个相对较大的参数值,双边控制系统就会失稳。这就促使我们为每个领导方和跟随方开发一个被动性观测器来计算总能量,并构建一种基于能量的检测方法,该方法可纳入加密的双边控制系统,并在所提出的定理中进行了总结。此外,本研究还提供了有关控制系统能量的合理阈值参数的具体设计。该定理和实验验证证实,所开发的基于波变量的加密双边控制系统与所提出的攻击检测器相结合,可安全有效地抵御基于可篡改性的攻击。
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引用次数: 0
Optimal data injection attack design for spacecraft systems via a model free Q-learning approach 通过无模型 Q-learning 方法优化航天器系统的数据注入攻击设计
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-14 DOI: 10.1049/cth2.12685
Huanhuan Yuan, Mengbi Wang, Chao Xi

This paper aims to analyse the dynamic response of a corrupted spacecraft rendezvous system from the perspective of attacker. The optimal data injection attack problem is formulated by constructing a tradeoff cost function in a quadratic form. First, the optimal attack strategy and associated sufficient condition for its existence are derived similar to optimal control for attacker without being detected. Breaking the assumption in most existing works, the goal of this paper is to explore the optimal attack strategy without knowing system matrices. A model free Q-learning approach is designed with the application to solve attacker's optimization problem. Critic network and action network are used to adaptive tuning the value and action for attacker in a forward time. For a more practical situation, a model free attack strategy design is implemented only based on measured input/output data. Finally, the simulation results on the spacecraft system are presented to show the effectiveness of the proposed method for model free attack strategy design.

本文旨在从攻击者的角度分析被破坏的航天器会合系统的动态响应。通过构建二次函数形式的权衡成本函数,提出了最优数据注入攻击问题。首先,推导出最优攻击策略及其存在的相关充分条件,类似于攻击者在不被检测到的情况下的最优控制。本文打破了大多数现有著作中的假设,目标是在不知道系统矩阵的情况下探索最优攻击策略。本文设计了一种无模型 Q-learning 方法,用于解决攻击者的优化问题。批评网络和行动网络用于在前向时间内自适应地调整攻击者的值和行动。在更实际的情况下,仅根据测量的输入/输出数据实施无模型攻击策略设计。最后,介绍了航天器系统的仿真结果,以说明所提出的无模型攻击策略设计方法的有效性。
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引用次数: 0
A mismatched composite disturbance observer-based adaptive tracking controller for robotic manipulators 基于错配复合干扰观测器的机器人操纵器自适应跟踪控制器
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-14 DOI: 10.1049/cth2.12690
Zhongtao Liu, Weikai He, Xiangbao Li, Cungen Liu, Huaizhi Shao, Peng Fu

The paper is devoted to the adaptive tracking control based on the mismatched disturbance observer for motor-driven robotic manipulators. A novel mismatched disturbance observer is introduced, which does not make bounded derivative assumptions on mismatched disturbances in the robotic manipulator system. Additionally, a new adaptive tracking controller for a motor-driven robotic manipulator based on the mismatched disturbance observer is designed, which guarantees that all closed-loop signals are globally uniformly bounded and the tracking error is asymptotic stable. Finally, the simulation comparisons are carried out between the proposed and existing control strategies to demonstrate the superiority of the developed controller.

本文致力于基于电机驱动机器人机械手的失配扰动观测器的自适应跟踪控制。本文介绍了一种新型的错配扰动观测器,它不对机器人操纵器系统中的错配扰动做有界导数假设。此外,基于失配扰动观测器为电机驱动机器人机械手设计了一种新的自适应跟踪控制器,它能保证所有闭环信号都是全局均匀有界的,并且跟踪误差是渐近稳定的。最后,对所提出的控制策略和现有控制策略进行了仿真比较,以证明所开发控制器的优越性。
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引用次数: 0
Adaptive fuzzy disturbance suppression for constrained nonlinear systems under faulty condition 故障条件下约束非线性系统的自适应模糊干扰抑制
IF 2.2 4区 计算机科学 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-14 DOI: 10.1049/cth2.12683
Meiying Yang, Li Tang

For a class of full-states constraints nonlinear system with actuator failure, an adaptive fuzzy disturbance observer tracking design is carried out by using Lyapunov function and the dynamic surface method. The integral explosion problem is avoided by using the dynamic surface design method. Because the disturbance of the system is unknown, a nonlinear fuzzy disturbance observer is designed to estimate the unknown disturbance. And the unknown nonlinear function is approximated fuzzy logic systems. Based on the Lyapunov function method and backstepping approach, the stability of considered systems are analysed. And the proposed method can guarantee that all the signals in the closed-loop system are bounded and the system output can track the desired signal to the small neighbourhood range. In addition, the fuzzy disturbance observer can estimate the unknown disturbance state well. Finally, several sets of simulation examples are given and compared with other method, and the experimental results are quantitatively analysed. Then, the robustness and superiority of the proposed control scheme are verified and demonstrated.

针对一类具有致动器失效的全状态约束非线性系统,利用 Lyapunov 函数和动态曲面法进行了自适应模糊扰动观测器跟踪设计。利用动态曲面设计方法避免了积分爆炸问题。由于系统的扰动是未知的,因此设计了一个非线性模糊扰动观测器来估计未知扰动。未知非线性函数是近似模糊逻辑系统。基于 Lyapunov 函数法和反步法,分析了所考虑系统的稳定性。所提出的方法能保证闭环系统中的所有信号都是有界的,系统输出能在小邻域范围内跟踪所需的信号。此外,模糊干扰观测器能很好地估计未知干扰状态。最后,给出了几组仿真实例,并与其他方法进行了比较,对实验结果进行了定量分析。然后,验证并证明了所提控制方案的鲁棒性和优越性。
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引用次数: 0
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IET Control Theory and Applications
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