首页 > 最新文献

Ideggyogyaszati Szemle-Clinical Neuroscience最新文献

英文 中文
Neurobehavioral impairments in ciprofloxacin- treated osteoarthritic adult rats. 环丙沙星治疗的成年骨关节炎大鼠的神经行为损伤。
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-09-30 DOI: 10.18071/isz.76.0327
Gabriella Kékesi, Eszter Ducza, Hristifor Gálity, Alexandra Büki, Kálmán Tóth, Gábor Tuboly, Gyöngyi Horváth

Background and purpose:

Ciprofloxacin (CIP) is a broad-spectrum antibiotic widely used in clinical practice to treat musculoskeletal infections. Fluoroquinolone-induced neurotoxic adverse events have been reported in a few case reports, all the preclinical studies on its neuropsychiatric side effects involved only healthy animals. This study firstly investigated the behavioral effects of CIP in an osteoarthritis rat model with joint destruction and pain, which can simulate inflammation-associated musculoskeletal pain. Furthermore, effects of CIP on regional brain-derived neurotrophic factor (BDNF) expression were examined given its major contributions to the neuromodulation and plasticity underlying behavior and cognition. 

.

Methods:

Fourteen days after induction of chronic osteoarthritis, animals were administered vehicle, 33 mg/kg or 100 mg/kg CIP for five days intraperitoneally. Motor activity, behavioral motivation, and psychomotor learning were examined in a reward-based behavioral test (Ambitus) on Day 4 and sensorimotor gating by the prepulse inhibition test on Day 5. Thereafter, the prolonged BDNF mRNA and protein expression levels were measured in the hippocampus and the prefrontal cortex. 

.

Results:

CIP dose-dependently reduced both locomotion and reward-motivated exploratory activity, accompanied with impaired learning ability. In contrast, there were no significant differences in startle reflex and sensory gating among treatment groups; however, CIP treatment reduced motor activity of the animals in this test, too. These alterations were associated with reduced BDNF mRNA and protein expression levels in the hippocampus but not the prefrontal cortex. 

.

Conclusion:

This study revealed the detrimental effects of CIP treatment on locomotor activity and motivation/learning ability during osteoarthritic condition, which might be due to, at least partially, deficient hippocampal BDNF expression and ensuing impairments in neural and synaptic plasticity.

.

背景和目的:环丙沙星(CIP)是一种广泛应用于临床治疗肌肉骨骼感染的广谱抗生素。氟喹诺酮引起的神经毒性不良事件已在少数病例报告中报道,所有关于其神经精神副作用的临床前研究仅涉及健康动物。本研究首次在具有关节破坏和疼痛的骨关节炎大鼠模型中研究了CIP的行为影响,该模型可以模拟炎症相关的肌肉骨骼疼痛。此外,还研究了CIP对区域性脑源性神经营养因子(BDNF)表达的影响,因为其对行为和认知的神经调控和可塑性有重要贡献 ;。方法:在诱导慢性骨关节炎14天后,动物腹膜内给予载体33 mg/kg或100 mg/kg CIP 5天。在第4天通过基于奖励的行为测试(Ambitus)检查运动活动、行为动机和心理运动学习,在第5天通过脉冲前抑制测试检查感觉运动门控。此后,在海马和前额叶皮层中测量延长的BDNF mRNA和蛋白质表达水平 ;。结果:CIP剂量依赖性地降低了运动和奖励动机的探索活动,并伴有学习能力受损。相反,治疗组在惊吓反射和感觉门控方面没有显著差异;然而,CIP处理也降低了该试验中动物的运动活性。这些变化与海马中BDNF mRNA和蛋白质表达水平降低有关,但与前额叶皮层无关 ;。结论:本研究揭示了CIP治疗对骨关节炎期间的运动活动和动机/学习能力的有害影响,这可能至少部分是由于海马BDNF表达不足以及随之而来的神经和突触可塑性损伤。。
{"title":"Neurobehavioral impairments in ciprofloxacin- treated osteoarthritic adult rats.","authors":"Gabriella Kékesi,&nbsp;Eszter Ducza,&nbsp;Hristifor Gálity,&nbsp;Alexandra Büki,&nbsp;Kálmán Tóth,&nbsp;Gábor Tuboly,&nbsp;Gyöngyi Horváth","doi":"10.18071/isz.76.0327","DOIUrl":"https://doi.org/10.18071/isz.76.0327","url":null,"abstract":"<p><strong>Background and purpose: </strong><p>Ciprofloxacin (CIP) is a broad-spectrum antibiotic widely used in clinical practice to treat musculoskeletal infections. Fluoroquinolone-induced neurotoxic adverse events have been reported in a few case reports, all the preclinical studies on its neuropsychiatric side effects involved only healthy animals. This study firstly investigated the behavioral effects of CIP in an osteoarthritis rat model with joint destruction and pain, which can simulate inflammation-associated musculoskeletal pain. Furthermore, effects of CIP on regional brain-derived neurotrophic factor (BDNF) expression were examined given its major contributions to the neuromodulation and plasticity underlying behavior and cognition.&nbsp;</p>.</p><p><strong>Methods: </strong><p>Fourteen days after induction of chronic osteoarthritis, animals were administered vehicle, 33 mg/kg or 100 mg/kg CIP for five days intraperitoneally. Motor activity, behavioral motivation, and psychomotor learning were examined in a reward-based behavioral test (Ambitus) on Day 4 and sensorimotor gating by the prepulse inhibition test on Day 5. Thereafter, the prolonged BDNF mRNA and protein expression levels were measured in the hippocampus and the prefrontal cortex.&nbsp;</p>.</p><p><strong>Results: </strong><p>CIP dose-dependently reduced both locomotion and reward-motivated exploratory activity, accompanied with impaired learning ability. In contrast, there were no significant differences in startle reflex and sensory gating among treatment groups; however, CIP treatment reduced motor activity of the animals in this test, too. These alterations were associated with reduced BDNF mRNA and protein expression levels in the hippocampus but not the prefrontal cortex.&nbsp;</p>.</p><p><strong>Conclusion: </strong><p>This study revealed the detrimental effects of CIP treatment on locomotor activity and motivation/learning ability during osteoarthritic condition, which might be due to, at least partially, deficient hippocampal BDNF expression and ensuing impairments in neural and synaptic plasticity.</p>.</p>","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"76 9-10","pages":"327-337"},"PeriodicalIF":0.8,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41150701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How our view of epileptogenesis and mechanism of epilepsy changes? The system epilepsies' concept]. 我们对癫痫发生和癫痫机制的看法如何改变?系统癫痫的概念]。
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2022-03-31 DOI: 10.18071/isz.75.0079
P. Halász, A. Szűcs
Background and purposeTo examine the ways of epileptogenesis closely linked to the system epilepsies' concept.MethodsWe follow the ways of epileptic transformation in the declarative memory-system, in the sleep/arousal twin-systems, in the perisylvian neuronal network and in postinjury epilepsy, which we consider a general model of the epileptic transformation.ResultsIn the presented systems, epileptogenesis shares a similar mechanism in the form of augmentation and derailment of plasticity and sleep-related synaptic homeo-stasis. This highlights the central role of NREM sleep in those epilepsies.ConclusionWe try to characterize the concept of system epilepsies and suggest a shared mechanism of epileptogenesis.
背景与目的探讨与系统性癫痫概念密切相关的癫痫发生途径。方法观察陈述性记忆系统、睡眠/觉醒双系统、外围神经网络和损伤后癫痫的癫痫转化方式,认为这是癫痫转化的一般模式。结果在上述系统中,癫痫发生的机制相似,均表现为可塑性的增强和脱轨以及与睡眠相关的突触稳态。这凸显了非快速眼动睡眠在癫痫发作中的核心作用。结论我们试图描述系统性癫痫的概念,并提出一种共同的癫痫发生机制。
{"title":"[How our view of epileptogenesis and mechanism of epilepsy changes? The system epilepsies' concept].","authors":"P. Halász, A. Szűcs","doi":"10.18071/isz.75.0079","DOIUrl":"https://doi.org/10.18071/isz.75.0079","url":null,"abstract":"Background and purpose\u0000To examine the ways of epileptogenesis closely linked to the system epilepsies' concept.\u0000\u0000\u0000Methods\u0000We follow the ways of epileptic transformation in the declarative memory-system, in the sleep/arousal twin-systems, in the perisylvian neuronal network and in postinjury epilepsy, which we consider a general model of the epileptic transformation.\u0000\u0000\u0000Results\u0000In the presented systems, epileptogenesis shares a similar mechanism in the form of augmentation and derailment of plasticity and sleep-related synaptic homeo-stasis. This highlights the central role of NREM sleep in those epilepsies.\u0000\u0000\u0000Conclusion\u0000We try to characterize the concept of system epilepsies and suggest a shared mechanism of epileptogenesis.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"75 3-04 1","pages":"79-97"},"PeriodicalIF":0.8,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67669625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New, innovative prognosis calculator for patients with metastatic spinal tumors]. [新的,创新的预后计算器为转移性脊柱肿瘤患者]。
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2022-03-31 DOI: 10.18071/isz.75.0117
T. Mezei, J. Báskay, P. Pollner, A. Horváth, Z. Nagy, G. Czigléczki, P. Banczerowski
Background and purposeThe aim of our research was to create a scoring system that predicts prognosis and recommends therapeutic options for patients with metastatic spine tumor. Increasing oncological treatment opportunities and prolonged survival have led to a growing need to address clinical symptoms caused by meta-stases of the primary tumor. Spinal metastases can cause a significant reduction in quality of life due to the caused neurological deficits. A scoring system that predicts prognosis with sufficient accuracy could help us to achieve personalised treatment options.MethodsMethods - We performed a retrospective clinical research of data from patients over 18 years of age who underwent surgery due to symptomatic spinal metastasis at the National Institute of Mental Disorders, Neurology and Neurosurgery between 2008 and 2018. Data from 454 patients were analysed. Survival analysis (Kaplan-Meier, log-rank, Cox model) was performed, network science-based correlation analysis was used to select the proper prognostic factors of our scoring system, such that its C value (predictive ability index) was maximized.ResultsMultivariate Cox analysis resulted in the identification of 5 independent prognostic factors (primary tumour type, age, ambulatory status, internal organ metastases, serum protein level). Our system predicted with an average accuracy of 70.6% over the 10-year study period.ConclusionOur large case series of surgical dataset of patients with symptomatic spinal metastasis was used to create a risk calculator system that can help in the choice of therapy. Our risk calculator is also available online at https://emk.semmelweis.hu/gerincmet.
背景与目的本研究的目的是建立一个评分系统,预测脊柱转移性肿瘤患者的预后并推荐治疗方案。越来越多的肿瘤治疗机会和延长的生存期导致越来越需要解决由原发肿瘤转移引起的临床症状。由于脊髓转移引起的神经功能缺陷,可导致生活质量显著降低。一个能够足够准确地预测预后的评分系统可以帮助我们实现个性化的治疗选择。方法:我们对2008年至2018年期间在国家精神障碍、神经病学和神经外科研究所因症状性脊柱转移而接受手术的18岁以上患者的数据进行了回顾性临床研究。分析了454例患者的数据。进行生存分析(Kaplan-Meier、log-rank、Cox模型),采用基于网络科学的相关性分析选择适合我们评分系统的预后因素,使其C值(预测能力指数)最大化。结果多因素Cox分析确定了5个独立的预后因素(原发肿瘤类型、年龄、运动状态、内脏器官转移、血清蛋白水平)。在10年的研究期间,我们的系统预测的平均准确率为70.6%。结论我们使用了大量有症状的脊柱转移患者的手术数据集来创建一个风险计算器系统,该系统可以帮助选择治疗方法。我们的风险计算器也可以在https://emk.semmelweis.hu/gerincmet上找到。
{"title":"[New, innovative prognosis calculator for patients with metastatic spinal tumors].","authors":"T. Mezei, J. Báskay, P. Pollner, A. Horváth, Z. Nagy, G. Czigléczki, P. Banczerowski","doi":"10.18071/isz.75.0117","DOIUrl":"https://doi.org/10.18071/isz.75.0117","url":null,"abstract":"Background and purpose\u0000The aim of our research was to create a scoring system that predicts prognosis and recommends therapeutic options for patients with metastatic spine tumor. Increasing oncological treatment opportunities and prolonged survival have led to a growing need to address clinical symptoms caused by meta-stases of the primary tumor. Spinal metastases can cause a significant reduction in quality of life due to the caused neurological deficits. A scoring system that predicts prognosis with sufficient accuracy could help us to achieve personalised treatment options.\u0000\u0000\u0000Methods\u0000Methods - We performed a retrospective clinical research of data from patients over 18 years of age who underwent surgery due to symptomatic spinal metastasis at the National Institute of Mental Disorders, Neurology and Neurosurgery between 2008 and 2018. Data from 454 patients were analysed. Survival analysis (Kaplan-Meier, log-rank, Cox model) was performed, network science-based correlation analysis was used to select the proper prognostic factors of our scoring system, such that its C value (predictive ability index) was maximized.\u0000\u0000\u0000Results\u0000Multivariate Cox analysis resulted in the identification of 5 independent prognostic factors (primary tumour type, age, ambulatory status, internal organ metastases, serum protein level). Our system predicted with an average accuracy of 70.6% over the 10-year study period.\u0000\u0000\u0000Conclusion\u0000Our large case series of surgical dataset of patients with symptomatic spinal metastasis was used to create a risk calculator system that can help in the choice of therapy. Our risk calculator is also available online at https://emk.semmelweis.hu/gerincmet.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"75 3-04 1","pages":"117-127"},"PeriodicalIF":0.8,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67669686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myasthenia gravis, Guillain-Barré-szindróma, vagy mindkettő?
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2020-01-01 DOI: 10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0060
Çağdaş Erdoğan, Selma Tekin, Zeynep Ünlütürk, Derya Korkut Gedik
{"title":"Myasthenia gravis, Guillain-Barré-szindróma, vagy mindkettő?","authors":"Çağdaş Erdoğan, Selma Tekin, Zeynep Ünlütürk, Derya Korkut Gedik","doi":"10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0060","DOIUrl":"https://doi.org/10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0060","url":null,"abstract":"","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"126 1","pages":"60-64"},"PeriodicalIF":0.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85321991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valproinsav-használat mellékhatásaként kialakuló PLeuropericardialis folyadékgyülem
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2020-01-01 DOI: 10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0070
Ulku Fıgen Demir
{"title":"Valproinsav-használat mellékhatásaként kialakuló PLeuropericardialis folyadékgyülem","authors":"Ulku Fıgen Demir","doi":"10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0070","DOIUrl":"https://doi.org/10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0070","url":null,"abstract":"","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"29 1","pages":"70-72"},"PeriodicalIF":0.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89738666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marchiafava-Bignami-betegség: három eset ismertetése
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2020-01-01 DOI: 10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0065
Günay Gül, Mesude Özerden, Zeynep Ozdemir, Cahit Keskinkiliç, Hakan Selcuk, Batuhan Kara, Aysun Soysal
{"title":"Marchiafava-Bignami-betegség: három eset ismertetése","authors":"Günay Gül, Mesude Özerden, Zeynep Ozdemir, Cahit Keskinkiliç, Hakan Selcuk, Batuhan Kara, Aysun Soysal","doi":"10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0065","DOIUrl":"https://doi.org/10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.73.0065","url":null,"abstract":"","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"48 1","pages":"65-69"},"PeriodicalIF":0.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74155542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Newer studies on the strong link between sleep and epilepsy: Epilepsy as an epileptic transformation of sleep plastic functions]. [关于睡眠和癫痫之间紧密联系的最新研究:癫痫是睡眠可塑性功能的癫痫转化]。
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2019-09-30 DOI: 10.18071/isz.72.0304
P. Halász
Aims - Overview of the new data about the strong link of sleep and epilepsy and conjoining cognitive impairment. Methods - Search for relevant references and summary of our own research activity on the topic. Results - Strong interrealtionship exists between epilepsy and plastic brain functions (memory processing and synaptic homeostasis) and the working modes of NREM sleep. In the most frequent childhood and adult epilepsy networks responsible for plastic functions can be derailed to an epileptic level of excitability, and suffer a transitory or permanent epileptic transformation. Exampling on the three big epilepsies: absence epilepsy; medial temporal lobe epilepsy; and childhood idiopathic focal age dependent epilepsy spectrum we demonstrate the most important features of this epileptic transformation. The association of cognitive impairment to certain sleep dependent epilepsies gains explanation by the epilepsy caused interference with slow wave decline (ICFE) and memory consolidation (MTLE) during NREM sleep. This paper serves also to introduce the concept of sleep dependent system epilepsies. Conclusions - We provide evidences about shared mechanisms among sleep related epilepsies being the derailment of sleep plastic funcions toward exaggerated excitability determined by the inherent possibilities of the signal transduction properties.
目的:综述有关睡眠与癫痫及相关认知障碍密切联系的新数据。方法-搜索相关的参考文献和总结我们自己的研究活动的主题。结果-癫痫与可塑性脑功能(记忆处理和突触稳态)以及非快速眼动睡眠的工作模式之间存在很强的相互关系。在最常见的儿童和成人癫痫网络负责可塑性功能可以脱轨到癫痫水平的兴奋性,并遭受短暂或永久的癫痫转化。以三大癫痫为例:缺乏性癫痫;内侧颞叶癫痫;以及儿童特发性局灶年龄依赖性癫痫谱,我们展示了这种癫痫转化的最重要特征。在非快速眼动睡眠期间,癫痫引起的慢波下降(ICFE)和记忆巩固(MTLE)干扰可以解释认知障碍与某些睡眠依赖性癫痫的关系。本文还介绍了睡眠依赖系统癫痫的概念。结论:我们提供了睡眠相关癫痫的共同机制的证据,即由信号转导特性的固有可能性决定的睡眠可塑性功能向过度兴奋性的脱轨。
{"title":"[Newer studies on the strong link between sleep and epilepsy: Epilepsy as an epileptic transformation of sleep plastic functions].","authors":"P. Halász","doi":"10.18071/isz.72.0304","DOIUrl":"https://doi.org/10.18071/isz.72.0304","url":null,"abstract":"Aims - Overview of the new data about the strong link of sleep and epilepsy and conjoining cognitive impairment. Methods - Search for relevant references and summary of our own research activity on the topic. Results - Strong interrealtionship exists between epilepsy and plastic brain functions (memory processing and synaptic homeostasis) and the working modes of NREM sleep. In the most frequent childhood and adult epilepsy networks responsible for plastic functions can be derailed to an epileptic level of excitability, and suffer a transitory or permanent epileptic transformation. Exampling on the three big epilepsies: absence epilepsy; medial temporal lobe epilepsy; and childhood idiopathic focal age dependent epilepsy spectrum we demonstrate the most important features of this epileptic transformation. The association of cognitive impairment to certain sleep dependent epilepsies gains explanation by the epilepsy caused interference with slow wave decline (ICFE) and memory consolidation (MTLE) during NREM sleep. This paper serves also to introduce the concept of sleep dependent system epilepsies. Conclusions - We provide evidences about shared mechanisms among sleep related epilepsies being the derailment of sleep plastic funcions toward exaggerated excitability determined by the inherent possibilities of the signal transduction properties.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"72 9-10 1","pages":"304-314"},"PeriodicalIF":0.8,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67670017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sleep habits among preschool- and schoolchildren]. 学龄前儿童和学龄儿童的睡眠习惯。
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2019-07-30 DOI: 10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0264
Fusz Katalin, Ritecz Bernadett, Balogh Brigitta, T. Krisztina, Somlai Eszter, Raposa L. Bence, Oláh András
Background and purpose: Celunk felmerni az alvasi szokasokat, az alvasminőseget es befolyasolo tenyezőit ovodas- es iskolaskoruak koreben. Methods: Ket kerdőives adatfelvetel tortent. Az 1. felmeres csecsemő- es ovodaskori altatasi szokasokkal, szoptatassal es egeszsegmagatartassal kapcsolatos kerdeseket, valamint a Children’s Sleep Habits Questionnaire-ből atvett kerdeseket tartalmaz. A 2. kerdőiv kerdesei az egeszseg-magatartasra es az alvashigienes szabalyok alkalmazasara vonatkoznak, valamint az Athen Insomnia Skalat tartalmazza. A vizsgalat alanyai - Osszesen 1063 kerdőivet ertekeltunk: 516 ovodaskoru gyermek szulője vett reszt online felmeresunkben Magyarorszag egesz teruleten; 547 altalanos es kozepiskolas vett reszt a 2. kerdőives felmeresben Szolnokon. Results: Parents' observation shows that the average nighttime sleeping time of kindergarten children is 10 hours 20 minutes on weekdays and 10 hours 36 minutes on weekends. The most popular sleeping habits in kindergarten age: teal reading (65.1%) and co-sleeping (42.8%). Parents of infants used breastfeeding (50.4%) and rocking (43.2%) most frequently before sleep. Co-sleeping has a positive influence on the length of lactation. Among the preschool sleeping habits we have proved a number of positive effects of teal reading, while watching television have negative effects. The sleep quality of school-age children according to the Athens Insomnia Scale is 6.11 points (SD: 4.11), 19% of the children are insomniac. Their sleep time is 7 hours 31 minutes on weekdays and 9 hours 30 minutes on weekends. The usage of good health behavior and sleep hygiene rules positively influence sleep quality and sleep duration. Conclusion: Eredmenyeinkkel szeretnenk felhivni a gyermekek es a szulők figyelmet az alvas fontossagara, az alvashigienes szabalyok betartasara.
{"title":"[Sleep habits among preschool- and schoolchildren].","authors":"Fusz Katalin, Ritecz Bernadett, Balogh Brigitta, T. Krisztina, Somlai Eszter, Raposa L. Bence, Oláh András","doi":"10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0264","DOIUrl":"https://doi.org/10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0264","url":null,"abstract":"Background and purpose: Celunk felmerni az alvasi szokasokat, az alvasminőseget es befolyasolo tenyezőit ovodas- es iskolaskoruak koreben. Methods: Ket kerdőives adatfelvetel tortent. Az 1. felmeres csecsemő- es ovodaskori altatasi szokasokkal, szoptatassal es egeszsegmagatartassal kapcsolatos kerdeseket, valamint a Children’s Sleep Habits Questionnaire-ből atvett kerdeseket tartalmaz. A 2. kerdőiv kerdesei az egeszseg-magatartasra es az alvashigienes szabalyok alkalmazasara vonatkoznak, valamint az Athen Insomnia Skalat tartalmazza. A vizsgalat alanyai - Osszesen 1063 kerdőivet ertekeltunk: 516 ovodaskoru gyermek szulője vett reszt online felmeresunkben Magyarorszag egesz teruleten; 547 altalanos es kozepiskolas vett reszt a 2. kerdőives felmeresben Szolnokon. Results: Parents' observation shows that the average nighttime sleeping time of kindergarten children is 10 hours 20 minutes on weekdays and 10 hours 36 minutes on weekends. The most popular sleeping habits in kindergarten age: teal reading (65.1%) and co-sleeping (42.8%). Parents of infants used breastfeeding (50.4%) and rocking (43.2%) most frequently before sleep. Co-sleeping has a positive influence on the length of lactation. Among the preschool sleeping habits we have proved a number of positive effects of teal reading, while watching television have negative effects. The sleep quality of school-age children according to the Athens Insomnia Scale is 6.11 points (SD: 4.11), 19% of the children are insomniac. Their sleep time is 7 hours 31 minutes on weekdays and 9 hours 30 minutes on weekends. The usage of good health behavior and sleep hygiene rules positively influence sleep quality and sleep duration. Conclusion: Eredmenyeinkkel szeretnenk felhivni a gyermekek es a szulők figyelmet az alvas fontossagara, az alvashigienes szabalyok betartasara.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"2015 1","pages":"264-272"},"PeriodicalIF":0.8,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87869141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Treatment of complex regional pain syndrome with amitriptyline]. [阿米替林治疗复杂局部疼痛综合征]。
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2019-07-30 DOI: 10.18071/isz.72.0279
S. Komoly
Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment. Case presentation - Here a posttraumatic severe case of complex regional pain syndrome is presented, successfully treated by amitriptyline monotherapy. Amitriptyline is one of the most effective evidence based treatments of peri-pheral diabetic neuropathic pain and other neuropathic pain syndromes. Discussion - Amitriptyline seems to be effective to decrease pain, autonomic and motor symptoms in chronic regional pain syndrome. Conclusion - Controlled trials may be warranted to test the effectiveness of amitriptyline in complex regional pain syndrome.
复杂局部疼痛综合征是一种没有已知病因和循证治疗的非应激神经性疼痛状况。病例介绍-这里的创伤后严重的情况下,复杂的区域疼痛综合征提出,成功治疗的阿米替林单一疗法。阿米替林是治疗周围性糖尿病神经性疼痛和其他神经性疼痛综合征最有效的循证治疗方法之一。讨论-阿米替林似乎对减轻慢性局部疼痛综合征的疼痛、自主神经和运动症状有效。结论:可能需要对照试验来检验阿米替林治疗复杂局部疼痛综合征的有效性。
{"title":"[Treatment of complex regional pain syndrome with amitriptyline].","authors":"S. Komoly","doi":"10.18071/isz.72.0279","DOIUrl":"https://doi.org/10.18071/isz.72.0279","url":null,"abstract":"Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment. Case presentation - Here a posttraumatic severe case of complex regional pain syndrome is presented, successfully treated by amitriptyline monotherapy. Amitriptyline is one of the most effective evidence based treatments of peri-pheral diabetic neuropathic pain and other neuropathic pain syndromes. Discussion - Amitriptyline seems to be effective to decrease pain, autonomic and motor symptoms in chronic regional pain syndrome. Conclusion - Controlled trials may be warranted to test the effectiveness of amitriptyline in complex regional pain syndrome.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"26 1","pages":"279-281"},"PeriodicalIF":0.8,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67669922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[In Memoriam Mátyás Bobest]. [纪念Matthias Bobes]。
IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2019-07-30 DOI: 10.18071/ISZ.72.0222
Ádám Kuncz
Mátyás Bobest died in May, 2019, at the age of 79, following a disease tolerated with patience. He was the 1st nominated Chef of the independent Neurosurgical Department at the Markusovszky University Teaching Hospital, Szombathely in 1980, and under his leadership it worked for 23 years. He succeed to create a Neurosurgical Centre of West Hungary with his diligent and ambitious work. Beside his everyday surgical duties he paid attention to the continuing medical education and made research on the intervertebral disc degeneration.
Mátyás Bobest于2019年5月去世,享年79岁,他一直在耐心地忍受着一种疾病。1980年,他被第一名提名为Szombathely Markusovszky大学教学医院独立神经外科的主任,并在他的领导下工作了23年。他的勤奋和雄心使他成功地在西匈牙利建立了一个神经外科中心。在日常外科工作之余,他注重继续医学教育,并对椎间盘退变进行了研究。
{"title":"[In Memoriam Mátyás Bobest].","authors":"Ádám Kuncz","doi":"10.18071/ISZ.72.0222","DOIUrl":"https://doi.org/10.18071/ISZ.72.0222","url":null,"abstract":"Mátyás Bobest died in May, 2019, at the age of 79, following a disease tolerated with patience. He was the 1st nominated Chef of the independent Neurosurgical Department at the Markusovszky University Teaching Hospital, Szombathely in 1980, and under his leadership it worked for 23 years. He succeed to create a Neurosurgical Centre of West Hungary with his diligent and ambitious work. Beside his everyday surgical duties he paid attention to the continuing medical education and made research on the intervertebral disc degeneration.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"72 7-8 1","pages":"222-223"},"PeriodicalIF":0.8,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67669865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Ideggyogyaszati Szemle-Clinical Neuroscience
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1