Aims - Overview of the new data about the strong link of sleep and epilepsy and conjoining cognitive impairment. Methods - Search for relevant references and summary of our own research activity on the topic. Results - Strong interrealtionship exists between epilepsy and plastic brain functions (memory processing and synaptic homeostasis) and the working modes of NREM sleep. In the most frequent childhood and adult epilepsy networks responsible for plastic functions can be derailed to an epileptic level of excitability, and suffer a transitory or permanent epileptic transformation. Exampling on the three big epilepsies: absence epilepsy; medial temporal lobe epilepsy; and childhood idiopathic focal age dependent epilepsy spectrum we demonstrate the most important features of this epileptic transformation. The association of cognitive impairment to certain sleep dependent epilepsies gains explanation by the epilepsy caused interference with slow wave decline (ICFE) and memory consolidation (MTLE) during NREM sleep. This paper serves also to introduce the concept of sleep dependent system epilepsies. Conclusions - We provide evidences about shared mechanisms among sleep related epilepsies being the derailment of sleep plastic funcions toward exaggerated excitability determined by the inherent possibilities of the signal transduction properties.
{"title":"[Newer studies on the strong link between sleep and epilepsy: Epilepsy as an epileptic transformation of sleep plastic functions].","authors":"P. Halász","doi":"10.18071/isz.72.0304","DOIUrl":"https://doi.org/10.18071/isz.72.0304","url":null,"abstract":"Aims - Overview of the new data about the strong link of sleep and epilepsy and conjoining cognitive impairment. Methods - Search for relevant references and summary of our own research activity on the topic. Results - Strong interrealtionship exists between epilepsy and plastic brain functions (memory processing and synaptic homeostasis) and the working modes of NREM sleep. In the most frequent childhood and adult epilepsy networks responsible for plastic functions can be derailed to an epileptic level of excitability, and suffer a transitory or permanent epileptic transformation. Exampling on the three big epilepsies: absence epilepsy; medial temporal lobe epilepsy; and childhood idiopathic focal age dependent epilepsy spectrum we demonstrate the most important features of this epileptic transformation. The association of cognitive impairment to certain sleep dependent epilepsies gains explanation by the epilepsy caused interference with slow wave decline (ICFE) and memory consolidation (MTLE) during NREM sleep. This paper serves also to introduce the concept of sleep dependent system epilepsies. Conclusions - We provide evidences about shared mechanisms among sleep related epilepsies being the derailment of sleep plastic funcions toward exaggerated excitability determined by the inherent possibilities of the signal transduction properties.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"72 9-10 1","pages":"304-314"},"PeriodicalIF":0.8,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67670017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-30DOI: 10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0264
Fusz Katalin, Ritecz Bernadett, Balogh Brigitta, T. Krisztina, Somlai Eszter, Raposa L. Bence, Oláh András
Background and purpose: Celunk felmerni az alvasi szokasokat, az alvasminőseget es befolyasolo tenyezőit ovodas- es iskolaskoruak koreben. Methods: Ket kerdőives adatfelvetel tortent. Az 1. felmeres csecsemő- es ovodaskori altatasi szokasokkal, szoptatassal es egeszsegmagatartassal kapcsolatos kerdeseket, valamint a Children’s Sleep Habits Questionnaire-ből atvett kerdeseket tartalmaz. A 2. kerdőiv kerdesei az egeszseg-magatartasra es az alvashigienes szabalyok alkalmazasara vonatkoznak, valamint az Athen Insomnia Skalat tartalmazza. A vizsgalat alanyai - Osszesen 1063 kerdőivet ertekeltunk: 516 ovodaskoru gyermek szulője vett reszt online felmeresunkben Magyarorszag egesz teruleten; 547 altalanos es kozepiskolas vett reszt a 2. kerdőives felmeresben Szolnokon. Results: Parents' observation shows that the average nighttime sleeping time of kindergarten children is 10 hours 20 minutes on weekdays and 10 hours 36 minutes on weekends. The most popular sleeping habits in kindergarten age: teal reading (65.1%) and co-sleeping (42.8%). Parents of infants used breastfeeding (50.4%) and rocking (43.2%) most frequently before sleep. Co-sleeping has a positive influence on the length of lactation. Among the preschool sleeping habits we have proved a number of positive effects of teal reading, while watching television have negative effects. The sleep quality of school-age children according to the Athens Insomnia Scale is 6.11 points (SD: 4.11), 19% of the children are insomniac. Their sleep time is 7 hours 31 minutes on weekdays and 9 hours 30 minutes on weekends. The usage of good health behavior and sleep hygiene rules positively influence sleep quality and sleep duration. Conclusion: Eredmenyeinkkel szeretnenk felhivni a gyermekek es a szulők figyelmet az alvas fontossagara, az alvashigienes szabalyok betartasara.
{"title":"[Sleep habits among preschool- and schoolchildren].","authors":"Fusz Katalin, Ritecz Bernadett, Balogh Brigitta, T. Krisztina, Somlai Eszter, Raposa L. Bence, Oláh András","doi":"10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0264","DOIUrl":"https://doi.org/10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0264","url":null,"abstract":"Background and purpose: Celunk felmerni az alvasi szokasokat, az alvasminőseget es befolyasolo tenyezőit ovodas- es iskolaskoruak koreben. Methods: Ket kerdőives adatfelvetel tortent. Az 1. felmeres csecsemő- es ovodaskori altatasi szokasokkal, szoptatassal es egeszsegmagatartassal kapcsolatos kerdeseket, valamint a Children’s Sleep Habits Questionnaire-ből atvett kerdeseket tartalmaz. A 2. kerdőiv kerdesei az egeszseg-magatartasra es az alvashigienes szabalyok alkalmazasara vonatkoznak, valamint az Athen Insomnia Skalat tartalmazza. A vizsgalat alanyai - Osszesen 1063 kerdőivet ertekeltunk: 516 ovodaskoru gyermek szulője vett reszt online felmeresunkben Magyarorszag egesz teruleten; 547 altalanos es kozepiskolas vett reszt a 2. kerdőives felmeresben Szolnokon. Results: Parents' observation shows that the average nighttime sleeping time of kindergarten children is 10 hours 20 minutes on weekdays and 10 hours 36 minutes on weekends. The most popular sleeping habits in kindergarten age: teal reading (65.1%) and co-sleeping (42.8%). Parents of infants used breastfeeding (50.4%) and rocking (43.2%) most frequently before sleep. Co-sleeping has a positive influence on the length of lactation. Among the preschool sleeping habits we have proved a number of positive effects of teal reading, while watching television have negative effects. The sleep quality of school-age children according to the Athens Insomnia Scale is 6.11 points (SD: 4.11), 19% of the children are insomniac. Their sleep time is 7 hours 31 minutes on weekdays and 9 hours 30 minutes on weekends. The usage of good health behavior and sleep hygiene rules positively influence sleep quality and sleep duration. Conclusion: Eredmenyeinkkel szeretnenk felhivni a gyermekek es a szulők figyelmet az alvas fontossagara, az alvashigienes szabalyok betartasara.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"2015 1","pages":"264-272"},"PeriodicalIF":0.8,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87869141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment. Case presentation - Here a posttraumatic severe case of complex regional pain syndrome is presented, successfully treated by amitriptyline monotherapy. Amitriptyline is one of the most effective evidence based treatments of peri-pheral diabetic neuropathic pain and other neuropathic pain syndromes. Discussion - Amitriptyline seems to be effective to decrease pain, autonomic and motor symptoms in chronic regional pain syndrome. Conclusion - Controlled trials may be warranted to test the effectiveness of amitriptyline in complex regional pain syndrome.
{"title":"[Treatment of complex regional pain syndrome with amitriptyline].","authors":"S. Komoly","doi":"10.18071/isz.72.0279","DOIUrl":"https://doi.org/10.18071/isz.72.0279","url":null,"abstract":"Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment. Case presentation - Here a posttraumatic severe case of complex regional pain syndrome is presented, successfully treated by amitriptyline monotherapy. Amitriptyline is one of the most effective evidence based treatments of peri-pheral diabetic neuropathic pain and other neuropathic pain syndromes. Discussion - Amitriptyline seems to be effective to decrease pain, autonomic and motor symptoms in chronic regional pain syndrome. Conclusion - Controlled trials may be warranted to test the effectiveness of amitriptyline in complex regional pain syndrome.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"26 1","pages":"279-281"},"PeriodicalIF":0.8,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67669922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mátyás Bobest died in May, 2019, at the age of 79, following a disease tolerated with patience. He was the 1st nominated Chef of the independent Neurosurgical Department at the Markusovszky University Teaching Hospital, Szombathely in 1980, and under his leadership it worked for 23 years. He succeed to create a Neurosurgical Centre of West Hungary with his diligent and ambitious work. Beside his everyday surgical duties he paid attention to the continuing medical education and made research on the intervertebral disc degeneration.
Mátyás Bobest于2019年5月去世，享年79岁，他一直在耐心地忍受着一种疾病。1980年，他被第一名提名为Szombathely Markusovszky大学教学医院独立神经外科的主任，并在他的领导下工作了23年。他的勤奋和雄心使他成功地在西匈牙利建立了一个神经外科中心。在日常外科工作之余，他注重继续医学教育，并对椎间盘退变进行了研究。
{"title":"[In Memoriam Mátyás Bobest].","authors":"Ádám Kuncz","doi":"10.18071/ISZ.72.0222","DOIUrl":"https://doi.org/10.18071/ISZ.72.0222","url":null,"abstract":"Mátyás Bobest died in May, 2019, at the age of 79, following a disease tolerated with patience. He was the 1st nominated Chef of the independent Neurosurgical Department at the Markusovszky University Teaching Hospital, Szombathely in 1980, and under his leadership it worked for 23 years. He succeed to create a Neurosurgical Centre of West Hungary with his diligent and ambitious work. Beside his everyday surgical duties he paid attention to the continuing medical education and made research on the intervertebral disc degeneration.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"72 7-8 1","pages":"222-223"},"PeriodicalIF":0.8,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67669865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0123
D. Zoltán, Tarjányi Szilvia, Nagy Helga
{"title":"Rehabilitation possibilities and results after neurosurgical intervention of brain tumors","authors":"D. Zoltán, Tarjányi Szilvia, Nagy Helga","doi":"10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0123","DOIUrl":"https://doi.org/10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0123","url":null,"abstract":"","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"5 1","pages":"123-129"},"PeriodicalIF":0.8,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72984023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-30DOI: 10.18071/HTTPS://DOI.ORG/10.18071/ISZ.72.0013
C. Ertsey, M. Magyar, T. Gyüre, E. Balogh, G. Bozsik
Tension type headache, the most common type of primary headaches, affects approximately 80% of the population. Mainly because of its high prevalence, the socio-economic consequences of tension type headache are significant. The pain in tension type headache is usually bilateral, mild to moderate, is of a pressing or tightening quality, and is not accompanied by other symptoms. Patients with frequent or daily occurrence of tension type headache may experience significant distress because of the condition. The two main therapeutic avenues of tension type headache are acute and prophylactic treatment. Simple or combined analgesics are the mainstay of acute treatment. Prophylactic treatment is needed in case of attacks that are frequent and/or difficult to treat. The first drugs of choice as preventatives of tension type headache are tricyclic antidepressants, with a special focus on amitriptyline, the efficacy of which having been documented in multiple double-blind, placebo-controlled studies. Among other antidepressants, the efficacy of mirtazapine and venlafaxine has been documented. There is weaker evidence about the efficacy of gabapentine, topiramate, and tizanidin. Non-pharmacological prophylactic methods of tension type headache with a documented efficacy include certain types of psychotherapy and acupuncture.
{"title":"Tension type headache and its treatment possibilities","authors":"C. Ertsey, M. Magyar, T. Gyüre, E. Balogh, G. Bozsik","doi":"10.18071/HTTPS://DOI.ORG/10.18071/ISZ.72.0013","DOIUrl":"https://doi.org/10.18071/HTTPS://DOI.ORG/10.18071/ISZ.72.0013","url":null,"abstract":"Tension type headache, the most common type of primary headaches, affects approximately 80% of the population. Mainly because of its high prevalence, the socio-economic consequences of tension type headache are significant. The pain in tension type headache is usually bilateral, mild to moderate, is of a pressing or tightening quality, and is not accompanied by other symptoms. Patients with frequent or daily occurrence of tension type headache may experience significant distress because of the condition. The two main therapeutic avenues of tension type headache are acute and prophylactic treatment. Simple or combined analgesics are the mainstay of acute treatment. Prophylactic treatment is needed in case of attacks that are frequent and/or difficult to treat. The first drugs of choice as preventatives of tension type headache are tricyclic antidepressants, with a special focus on amitriptyline, the efficacy of which having been documented in multiple double-blind, placebo-controlled studies. Among other antidepressants, the efficacy of mirtazapine and venlafaxine has been documented. There is weaker evidence about the efficacy of gabapentine, topiramate, and tizanidin. Non-pharmacological prophylactic methods of tension type headache with a documented efficacy include certain types of psychotherapy and acupuncture.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"8 1","pages":"13-21"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75606196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-30DOI: 10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0023
I. Molnár, G. Hegyi, Z. Kovács, G. Kapócs, H. Szőke
Background and purpose: Annak felmerese, hogy heterogen betegcsoportban a fajdalomterapia milyen szinten kepes befolyasolni az idult fajdalmakat, ez milyen hatassal van a betegek eletminősegere, es az elert valtozasok milyen osszefuggesben allnak az eletkorral es az alapbetegsegekkel. A felmeres annak nepegeszsegugyi vonzata miatt is aktualis. Methods: Altalanos fajdalomambulancian vegzett prospektiv, nem randomizalt, valos helyzetű, intervencionalis, klinikai kohortvizsgalat, ami hat honapon at zajlott. A fajdalom intenzitasanak valtozasat vizualis analog skala (VAS) es az eletminősegi valtozasokat roviditett formaju, egeszseggel osszefuggő eletminőseget felmerő kerdőiv (SF-36 HRQoL) alkalmazasaval kovettuk. Mindket modszer validalt es nemzetkozileg elfogadott. A kerdőivek kitolteset minden beteg sajat kezűleg vegezte - igy onertekelessel kozoltek informaciot allapotukrol. Minden beteg kezeles utani eredmenyeit hasonlitottuk ossze a kezeles előttiekkel. A kulonbsegek alapjan megallapitott eletminősegi valtozasokat a magyarorszagi egeszseges populacio reprezentativ normaihoz viszonyitottuk. A vizsgalat alanyai - A felmeresben a betegek onkentesen, sajat elhatarozasuk alapjan vettek reszt. A kronikus fajdalmakat kivalto korfolyamat, a betegek kora, neme nem korlatozta a vizsgalatba tortenő bevalasztast. Results: 231 beteg adatait ertekeltuk. Az alkalmazott fajdalomterapias kezelesek utan a fajdalom intenzitasanak csokkenese VAS alapjan p = 0,002 szinten igazolodott szignifikansnak. Az SF-36 HRQoL segitsegevel mert eletminősegi valtozasok ferfiaknal p = 0,003, nőbetegeinknel p = 0,002 szignifikanciaszintű javulast igazoltak. A korrelacios egyutthatok alapjan az eletminősegi valtozasok a betegek eletkoratol es a fajdalmakat kivalto alapbetegsegek jellegetől fuggetlenul jottek letre. Conclusion: Although analgesia is basicly a symptomatic therapy, our findings suggest that the reduction of pain improves the quality of life of patients independently from their, and the curability of the underlying and accompanying diseases.
{"title":"The effect of palliative neural therapy on the improvement of chronic pain","authors":"I. Molnár, G. Hegyi, Z. Kovács, G. Kapócs, H. Szőke","doi":"10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0023","DOIUrl":"https://doi.org/10.18071/ISZ.HTTPS://DOI.ORG/10.18071/ISZ.72.0023","url":null,"abstract":"Background and purpose: Annak felmerese, hogy heterogen betegcsoportban a fajdalomterapia milyen szinten kepes befolyasolni az idult fajdalmakat, ez milyen hatassal van a betegek eletminősegere, es az elert valtozasok milyen osszefuggesben allnak az eletkorral es az alapbetegsegekkel. A felmeres annak nepegeszsegugyi vonzata miatt is aktualis. Methods: Altalanos fajdalomambulancian vegzett prospektiv, nem randomizalt, valos helyzetű, intervencionalis, klinikai kohortvizsgalat, ami hat honapon at zajlott. A fajdalom intenzitasanak valtozasat vizualis analog skala (VAS) es az eletminősegi valtozasokat roviditett formaju, egeszseggel osszefuggő eletminőseget felmerő kerdőiv (SF-36 HRQoL) alkalmazasaval kovettuk. Mindket modszer validalt es nemzetkozileg elfogadott. A kerdőivek kitolteset minden beteg sajat kezűleg vegezte - igy onertekelessel kozoltek informaciot allapotukrol. Minden beteg kezeles utani eredmenyeit hasonlitottuk ossze a kezeles előttiekkel. A kulonbsegek alapjan megallapitott eletminősegi valtozasokat a magyarorszagi egeszseges populacio reprezentativ normaihoz viszonyitottuk. A vizsgalat alanyai - A felmeresben a betegek onkentesen, sajat elhatarozasuk alapjan vettek reszt. A kronikus fajdalmakat kivalto korfolyamat, a betegek kora, neme nem korlatozta a vizsgalatba tortenő bevalasztast. Results: 231 beteg adatait ertekeltuk. Az alkalmazott fajdalomterapias kezelesek utan a fajdalom intenzitasanak csokkenese VAS alapjan p = 0,002 szinten igazolodott szignifikansnak. Az SF-36 HRQoL segitsegevel mert eletminősegi valtozasok ferfiaknal p = 0,003, nőbetegeinknel p = 0,002 szignifikanciaszintű javulast igazoltak. A korrelacios egyutthatok alapjan az eletminősegi valtozasok a betegek eletkoratol es a fajdalmakat kivalto alapbetegsegek jellegetől fuggetlenul jottek letre. Conclusion: Although analgesia is basicly a symptomatic therapy, our findings suggest that the reduction of pain improves the quality of life of patients independently from their, and the curability of the underlying and accompanying diseases.","PeriodicalId":50394,"journal":{"name":"Ideggyogyaszati Szemle-Clinical Neuroscience","volume":"3 1","pages":"23-31"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89276373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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