Pub Date : 2024-05-20DOI: 10.2174/0122133356303594240502052813
Nazia Kausar
Transition-metal catalysed activation of unreactive C-H bonds and subsequent C-C bond formation has emerged as a principal and essential tool in the field of synthetic organic chemistry. On the other hand, the microwave heating technique has been intensively used to carry out organic transformation of almost all kinds and has become a promising non-conventional technique for performing synthetic reactions. Direct C-H activation for C-C bond-forming reactions using ruthe-nium as a catalyst is currently a hot topic and represents a cost-effective synthetic pathway in or-ganic chemistry which is accompanied by the advantages of MW irradiation resulting in shorter reaction time and greener 3 as well as sustainable accomplishments.
{"title":"A Decade of Advancement in Ruthenium (II)-Catalyzed Direct C-H Activa-tion and Consequent C-C/C-N Bond Formation Using Microwave Heating","authors":"Nazia Kausar","doi":"10.2174/0122133356303594240502052813","DOIUrl":"https://doi.org/10.2174/0122133356303594240502052813","url":null,"abstract":"\u0000\u0000Transition-metal catalysed activation of unreactive C-H bonds and subsequent C-C bond formation has emerged as a principal and essential tool in the field of synthetic organic chemistry. On the other hand, the microwave heating technique has been intensively used to carry out organic transformation of almost all kinds and has become a promising non-conventional technique for performing synthetic reactions. Direct C-H activation for C-C bond-forming reactions using ruthe-nium as a catalyst is currently a hot topic and represents a cost-effective synthetic pathway in or-ganic chemistry which is accompanied by the advantages of MW irradiation resulting in shorter reaction time and greener 3 as well as sustainable accomplishments.\u0000","PeriodicalId":503957,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.2174/0122133356294226240228103251
Parth Manvar, Dharmesh Katariya, Amita Vyas, Pooja Bhanderi, R. Khunt
Microwave assisted ecofriendly catalytic protocol for the Groebke-Blackburn-Bienayme multicomponent reaction to synthesis imidazo[1,2-a]pyridine-furan hybrids as possible therapeutic option for leukemia, colon cancer and prostate cancer Microwave synthesis has emerged as a potent tool for the more economical and environmentally friendly synthesis of organic compounds, such as derivatives of imidazo[1,2-a]pyridine. Compared to traditional synthesis, microwave radiation causes molecules to be excited and distributes thermal energy evenly in a shorter amount of time. Shorter response times and generally improved efficiency are the benefits of this. The primary objective of the work presented in this article was to prepare imidazo[1,2-a]pyridine-furan hybrids via Groebke-Blackburn-Bienayme multicomponent reaction using PEG 400 in microwave irradiation as green approach. characterized their anticancer activities against leukemia, colon cancer and prostate cancer are evaluated. In a sealed microwave glass vial, 5-methylfuran-2-carbaldehyde 1, 2-aminoazines 2a-g, isocyanides 3a-c in presence of 20mol We have successfully synthesised the imidazo[1,2-a]pyridine-furan hybrids via Groebke-Blackburn-Bienayme multicomponent reaction using PEG 400 in microwave irradiation as green approach. The structures of the compounds were confirmed through various spectroscopic techniques. Characterized their anticancer activities against leukemia, colon cancer and prostate cancer are evaluated. The reported protocol is advantageous over conventional methods of imidazo[1,2-a]pyridine derivatives. The time required for the reaction is much less as compared to the usual requirements of reflux. Compound 4e, 4f, 4n and 4o shows the most increased activity against cell line RPMI-8226, HCT-116 and PC-3 of Leukemia, Colon cancer and Prostate cancer respectively. By using the potential of imidazo[1,2-a]pyridine-furan based compounds via sustainable green approach, more effective and accurate cancer treatments can be designed in future. NA
{"title":"Microwave Assisted Groebke-Blackburn-Bienayme Multicomponent Reaction to Synthesis of Imidazo[1,2-a]pyridine-furan Hybrids as Possible Therapeutic Option for Leukemia, Colon Cancer and Prostate Cancer","authors":"Parth Manvar, Dharmesh Katariya, Amita Vyas, Pooja Bhanderi, R. Khunt","doi":"10.2174/0122133356294226240228103251","DOIUrl":"https://doi.org/10.2174/0122133356294226240228103251","url":null,"abstract":"\u0000\u0000Microwave assisted ecofriendly catalytic protocol for the Groebke-Blackburn-Bienayme multicomponent reaction to synthesis imidazo[1,2-a]pyridine-furan hybrids as possible therapeutic option for leukemia, colon cancer and prostate cancer\u0000\u0000\u0000\u0000Microwave synthesis has emerged as a potent tool for the more economical and environmentally friendly synthesis of organic compounds, such as derivatives of imidazo[1,2-a]pyridine. Compared to traditional synthesis, microwave radiation causes molecules to be excited and distributes thermal energy evenly in a shorter amount of time. Shorter response times and generally improved efficiency are the benefits of this.\u0000\u0000\u0000\u0000The primary objective of the work presented in this article was to prepare imidazo[1,2-a]pyridine-furan hybrids via Groebke-Blackburn-Bienayme multicomponent reaction using PEG 400 in microwave irradiation as green approach. characterized their anticancer activities against leukemia, colon cancer and prostate cancer are evaluated.\u0000\u0000\u0000\u0000In a sealed microwave glass vial, 5-methylfuran-2-carbaldehyde 1, 2-aminoazines 2a-g, isocyanides 3a-c in presence of 20mol\u0000\u0000\u0000\u0000We have successfully synthesised the imidazo[1,2-a]pyridine-furan hybrids via Groebke-Blackburn-Bienayme multicomponent reaction using PEG 400 in microwave irradiation as green approach. The structures of the compounds were confirmed through various spectroscopic techniques. Characterized their anticancer activities against leukemia, colon cancer and prostate cancer are evaluated.\u0000\u0000\u0000\u0000The reported protocol is advantageous over conventional methods of imidazo[1,2-a]pyridine derivatives. The time required for the reaction is much less as compared to the usual requirements of reflux. Compound 4e, 4f, 4n and 4o shows the most increased activity against cell line RPMI-8226, HCT-116 and PC-3 of Leukemia, Colon cancer and Prostate cancer respectively. By using the potential of imidazo[1,2-a]pyridine-furan based compounds via sustainable green approach, more effective and accurate cancer treatments can be designed in future.\u0000\u0000\u0000\u0000NA\u0000","PeriodicalId":503957,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140387452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-16DOI: 10.2174/0122133356293561240212114651
R. Cerón-Camacho
Microwave-assisted synthesis has faced challenges in implementing its use at the in-dustrial level in recent decades, including scaling up the processes. While microwave-assisted synthesis is established on a laboratory scale, there are some drawbacks associated with it, in-cluding the equipment and operational costs of the specialized microwave reactors, safety con-cerns due to high temperatures and pressures, reaction selectivity, capacity to control the rapid heating and cooling rates associated with the kinetics of some reactions, and optimization of re-producibility in the results. This manuscript discusses the relevant and recent news in the last ten years about the application of industrial reactors for producing chemicals at the industrial level.
{"title":"Recent Advances in Using Microwaves to Prepare Chemicals at the Industrial Level","authors":"R. Cerón-Camacho","doi":"10.2174/0122133356293561240212114651","DOIUrl":"https://doi.org/10.2174/0122133356293561240212114651","url":null,"abstract":"\u0000\u0000Microwave-assisted synthesis has faced challenges in implementing its use at the in-dustrial level in recent decades, including scaling up the processes. While microwave-assisted synthesis is established on a laboratory scale, there are some drawbacks associated with it, in-cluding the equipment and operational costs of the specialized microwave reactors, safety con-cerns due to high temperatures and pressures, reaction selectivity, capacity to control the rapid heating and cooling rates associated with the kinetics of some reactions, and optimization of re-producibility in the results. This manuscript discusses the relevant and recent news in the last ten years about the application of industrial reactors for producing chemicals at the industrial level.\u0000","PeriodicalId":503957,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-26DOI: 10.2174/0122133356284914231231103738
Mahesh Namballa, Anilkumar Adimulapu, Rajesh E. Jesudasan
Polysaccharides have recently attracted a lot of attention in the designing of drug delivery systems due to their wide availability, lack of toxicity, and numerous ways that their nature, structure, and functionality can be altered. Polysaccharide has recently attracted a lot of attention in the designing of drug delivery systems due to its wide availability, lack of toxicity, and numerous ways that its nature, structure, and functionality can be altered. Microwave-assisted synthesis of graft copolymer of tragacanth (TRA) is done with poly-acrylamide (PAM) by free radical polymerization using ceric ammonium nitrate (CAN) as initiator. Grafting polymer concentration, CAN concentration, and exposure time were selected as independent variables, and their effect is studied for Grafting Efficiency (GE) and Intrinsic viscosity (IV) using Box-Behnken optimization design. Microwave assisted synthesis of graft copolymer of tragacanth (TRA) is done with polyacrylamide (PAM) by free radical polymerization using ceric ammonium nitrate (CAN) as initiator. A quadratic model was suggested by the software for further statistical evaluation. On the basis of the desirability approach, optimized parameters for microwave-assisted synthesis were demonstrated, and further grafted TRA (Gr-TRA) was synthesized. Gr-TRA was studied for various characterization and elemental analysis. Gr-TRA showed the highest swelling index and least weight loss during the chemical resistance test. Further instrumental analyses like FTIR, XRD, and elemental analysis confirmed the formation of Gr-TRA. Based on all of the above findings, the synthesis of PAM-grafted TRA has been optimized and could be used as a new pharmaceutical excipient in designing different dosage forms.
{"title":"QbD Assisted Optimization of Microwave-assisted Synthesis of Polyacrylamide Grafted Tragacanth: Characterization and Instrumental Analysis","authors":"Mahesh Namballa, Anilkumar Adimulapu, Rajesh E. Jesudasan","doi":"10.2174/0122133356284914231231103738","DOIUrl":"https://doi.org/10.2174/0122133356284914231231103738","url":null,"abstract":"\u0000\u0000Polysaccharides have recently attracted a lot of attention in the designing of drug delivery systems due to their wide availability, lack of toxicity, and numerous ways that their nature, structure, and functionality can be altered.\u0000\u0000\u0000\u0000Polysaccharide has recently attracted a lot of attention in the designing of drug delivery systems due to its wide availability, lack of toxicity, and numerous ways that its nature, structure, and functionality can be altered.\u0000\u0000\u0000\u0000Microwave-assisted synthesis of graft copolymer of tragacanth (TRA) is done with poly-acrylamide (PAM) by free radical polymerization using ceric ammonium nitrate (CAN) as initiator. Grafting polymer concentration, CAN concentration, and exposure time were selected as independent variables, and their effect is studied for Grafting Efficiency (GE) and Intrinsic viscosity (IV) using Box-Behnken optimization design.\u0000\u0000\u0000\u0000Microwave assisted synthesis of graft copolymer of tragacanth (TRA) is done with polyacrylamide (PAM) by free radical polymerization using ceric ammonium nitrate (CAN) as initiator.\u0000\u0000\u0000\u0000A quadratic model was suggested by the software for further statistical evaluation. On the basis of the desirability approach, optimized parameters for microwave-assisted synthesis were demonstrated, and further grafted TRA (Gr-TRA) was synthesized. Gr-TRA was studied for various characterization and elemental analysis. Gr-TRA showed the highest swelling index and least weight loss during the chemical resistance test. Further instrumental analyses like FTIR, XRD, and elemental analysis confirmed the formation of Gr-TRA.\u0000\u0000\u0000\u0000Based on all of the above findings, the synthesis of PAM-grafted TRA has been optimized and could be used as a new pharmaceutical excipient in designing different dosage forms.\u0000","PeriodicalId":503957,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140493309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-27DOI: 10.2174/0122133356267953231101093319
Parin V. Shaikh, D. I. Brahmbhatt
This is a comparative study of some new coumarin substituted thioaryl pyrazolyl pyrazoline. The target compounds were synthesized using both conventional as well as microwave irradiation by reaction of coumarin chalcones with different substituted hydrazine hydrates and aryl hydrazines to give the resultant pyrazoline derivatives. Microwave reaction, enhanced organic reactions, and reduced reaction time led to better yields and selectivity than conventional methods. The obtained compounds were characterized by different spectroscopic analysis including IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental-analysis and evaluated for their antimicrobial screening against a representative panel of bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi) and fungi (Aspergillus niger, Candida albicans). In the present study, we have synthesized coumarin pyrazoline derivatives clubbed with benzofuran pyrazole via both conventional and microwave irradiation and also subjected to antibacterial and antifungal studies. Synthesis of target compounds by the microwave irradiation enhanced reaction rate and reduced reaction time led to better yields and selectivity than conventional methods. The study of antibacterial and antifungal activities revealed that all the compounds exhibited reasonable to excellent activities against the pathogenic strains.
{"title":"Conventional versus Microwave Induced Synthesis and Biological Evolution of Coumarin Substituted Thioaryl Pyrazolyl Pyrazoline","authors":"Parin V. Shaikh, D. I. Brahmbhatt","doi":"10.2174/0122133356267953231101093319","DOIUrl":"https://doi.org/10.2174/0122133356267953231101093319","url":null,"abstract":"This is a comparative study of some new coumarin substituted thioaryl pyrazolyl pyrazoline. The target compounds were synthesized using both conventional as well as microwave irradiation by reaction of coumarin chalcones with different substituted hydrazine hydrates and aryl hydrazines to give the resultant pyrazoline derivatives. Microwave reaction, enhanced organic reactions, and reduced reaction time led to better yields and selectivity than conventional methods. The obtained compounds were characterized by different spectroscopic analysis including IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental-analysis and evaluated for their antimicrobial screening against a representative panel of bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi) and fungi (Aspergillus niger, Candida albicans). In the present study, we have synthesized coumarin pyrazoline derivatives clubbed with benzofuran pyrazole via both conventional and microwave irradiation and also subjected to antibacterial and antifungal studies. Synthesis of target compounds by the microwave irradiation enhanced reaction rate and reduced reaction time led to better yields and selectivity than conventional methods. The study of antibacterial and antifungal activities revealed that all the compounds exhibited reasonable to excellent activities against the pathogenic strains.","PeriodicalId":503957,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-27DOI: 10.2174/0122133356274136231116122126
Pedro Henrique Costa dos Santos, Virgínia Luíza Guimarães Souza, Augusto César Carvalho Santos, Henrique Esteves, L. Modolo, Ângelo de Fátima
Biginelli adducts, also known as dihydropyrimidin-2(1H)-ones/-thiones (DHMPs), exhibit versatile biological activities. Among them, monastrol has gained significant popularity as an inhibitor of kinesin-5 (Eg5), a motor protein crucial for spindle bipolarity. The inhibitory effect of monastrol on Eg5 accounts for its promising anticancer properties, along with its well-established role as an anti-inflammatory agent and calcium channel inhibitor. Since its first report in 1893, the Biginelli reaction has been extensively studied from various angles, including the scope of reagents used, the incorporation or omission of catalysts and solvents, and the application of innovative techniques like mechanochemical and ultrasonic reactors. Among these methods, microwave irradiation (MWI) has shown remarkable promise, aligning with the principles of green chemistry by offering solvent-free conditions, eco-friendly catalysts, and accelerated reaction times, ultimately leading to higher yields with a reduced environmental impact. In this mini-review, we shed light on the literature surrounding the synthesis of Biginelli adducts using MWI and highlight how this heating method can significantly enhance the preparation of this important class of bioactive compounds. By exploring the benefits of MWI, we aim to contribute to the advancement of greener and more efficient synthetic routes for bioactive substances.
{"title":"Synthesis of Biginelli Compounds using Microwave-Assisted Methods","authors":"Pedro Henrique Costa dos Santos, Virgínia Luíza Guimarães Souza, Augusto César Carvalho Santos, Henrique Esteves, L. Modolo, Ângelo de Fátima","doi":"10.2174/0122133356274136231116122126","DOIUrl":"https://doi.org/10.2174/0122133356274136231116122126","url":null,"abstract":"Biginelli adducts, also known as dihydropyrimidin-2(1H)-ones/-thiones (DHMPs), exhibit versatile biological activities. Among them, monastrol has gained significant popularity as an inhibitor of kinesin-5 (Eg5), a motor protein crucial for spindle bipolarity. The inhibitory effect of monastrol on Eg5 accounts for its promising anticancer properties, along with its well-established role as an anti-inflammatory agent and calcium channel inhibitor. Since its first report in 1893, the Biginelli reaction has been extensively studied from various angles, including the scope of reagents used, the incorporation or omission of catalysts and solvents, and the application of innovative techniques like mechanochemical and ultrasonic reactors. Among these methods, microwave irradiation (MWI) has shown remarkable promise, aligning with the principles of green chemistry by offering solvent-free conditions, eco-friendly catalysts, and accelerated reaction times, ultimately leading to higher yields with a reduced environmental impact. In this mini-review, we shed light on the literature surrounding the synthesis of Biginelli adducts using MWI and highlight how this heating method can significantly enhance the preparation of this important class of bioactive compounds. By exploring the benefits of MWI, we aim to contribute to the advancement of greener and more efficient synthetic routes for bioactive substances.","PeriodicalId":503957,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139232742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-22DOI: 10.2174/0122133356268693231114052121
M. Kamboj, S. Bajpai, Garima Pandey, Monika Yadav, B. K. Banik
One of the most efficient non-conventional heating methods is microwave irradiation. In organic synthesis, microwave irradiation has become a popular heating technique as it enhances product yields and purities, reduces reaction time from hours to minutes, and decreases unwanted side reactions. Microwave-assisted organic synthesis utilizes dielectric volumetric heating as an alternative activation method, which results in rapid and more selective transformations because of the uniform heat distribution. Heterocyclic compounds have a profound role in the drug discov-ery and development process along with their applications as agrochemicals, fungicides, herbi-cides, etc., making them the most prevalent form of biologically relevant molecules. Hence, enor-mous efforts have been made to flourish green routes for their high-yielding synthesis under mi-crowave irradiation as a sustainable tool. Among the different clinical applications, heterocyclic compounds have received considerable attention as anti-cancer agents. Heterocyclic moieties have always been core parts of the development of anti-cancer drugs, including market-selling drugs, i.e., 5-fluorouracil, doxorubicin, methotrexate, daunorubicin, etc., and natural alkaloids, such as vinblastine and vincristine. In this review, we focus on the developments in the microwave-assisted synthesis of heterocycles and the anti-cancer activities of particular heterocycles.
{"title":"Microwave-Assisted Synthesis of Biologically Relevant Six-Membered N- Heterocycles","authors":"M. Kamboj, S. Bajpai, Garima Pandey, Monika Yadav, B. K. Banik","doi":"10.2174/0122133356268693231114052121","DOIUrl":"https://doi.org/10.2174/0122133356268693231114052121","url":null,"abstract":"One of the most efficient non-conventional heating methods is microwave irradiation. In organic synthesis, microwave irradiation has become a popular heating technique as it enhances product yields and purities, reduces reaction time from hours to minutes, and decreases unwanted side reactions. Microwave-assisted organic synthesis utilizes dielectric volumetric heating as an alternative activation method, which results in rapid and more selective transformations because of the uniform heat distribution. Heterocyclic compounds have a profound role in the drug discov-ery and development process along with their applications as agrochemicals, fungicides, herbi-cides, etc., making them the most prevalent form of biologically relevant molecules. Hence, enor-mous efforts have been made to flourish green routes for their high-yielding synthesis under mi-crowave irradiation as a sustainable tool. Among the different clinical applications, heterocyclic compounds have received considerable attention as anti-cancer agents. Heterocyclic moieties have always been core parts of the development of anti-cancer drugs, including market-selling drugs, i.e., 5-fluorouracil, doxorubicin, methotrexate, daunorubicin, etc., and natural alkaloids, such as vinblastine and vincristine. In this review, we focus on the developments in the microwave-assisted synthesis of heterocycles and the anti-cancer activities of particular heterocycles.","PeriodicalId":503957,"journal":{"name":"Current Microwave Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139249732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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