The nineteenth century is often remembered as the age in which steamships and steam locomotives connected the globe with a speed and efficiency previously unseen. Although contemporaries frequently equated the use of these rapid-transportation technologies with the progress of civilization, their expansion also had some negative consequences. Among these was the more rapid and widespread diffusion of many diseases along transportation corridors as nonhuman stowaways on ships and trains. Most infamously, cholera extended its reach globally by appropriating and using modern transportation routes in ways that were unintended and disastrous for their human creators. This article goes beyond the technological optimism of the time, and its now widely accepted pitfalls, and expands the scope of Anatolian provincial modernization to incorporate a complex web of interactions between human and nonhuman agents in the context of technological use and nonuse. It argues for a complex cocreation of modern conditions between these agents, rather than seeing these conditions as solely produced by human actions or environmental limits. Among the different human agents, interaction greatly increased between Ottomans and European states and their citizens. As the Ottoman Empire became increasingly integrated into global transportation and economic networks, it also experienced the spread of cholera. In the Anatolian interior, cholera epidemics spread along the railroad. I examine the 1893 cholera epidemic in Eskişehir, an important junction town on the Ottoman Anatolian Railroad, which had just begun operation the previous year. The railroad was widely celebrated for its intended uses: tremendously increasing the speed and transportable volume of cargo and enabling travel for military and nonmilitary purposes. The cholera epidemic, however, was enabled by the unwitting use of the railroad lines as conveyors of sickness and death. Furthermore, human attempts to stop cholera's spread by interrupting train service undermined the technology's intended uses but also demonstrated the availability and potential effectiveness of nonuse as an option.