Humans are routinely exposed to radiation when receiving cancer treatment, fighting nuclear weapons, exploring space, and flying. Radiation exposure damages biological components such as protein, lipids, and cell membranes because it causes oxidative stress and inflammatory mediators, which can lead to DNA destruction even at low concentrations. Protecting people from the harmful effects of radiation is a challenging task due to the plethora of side effects of the chemical compounds used to mitigate DNA damage in normal cells. Hospitals continue to utilize radiotherapy for cancer treatment; yet, the adverse effects of the radiation they emit have outweighed the benefits. Plant phytochemicals and their derivatives exhibit diverse biological functions, often perceived as innocuous due to their non-toxic nature within subcellular and cellular environments. Moreover, they possess the capability to mitigate radiation-induced damage. This review aims to delineate the radioprotective attributes of plant polyphenols and extracts, elucidating their mechanisms of action across various models.
人类在接受癌症治疗、对抗核武器、探索太空和飞行时经常受到辐射。辐照会破坏蛋白质、脂质和细胞膜等生物成分，因为它会导致氧化应激和炎症介质，即使浓度很低也会导致 DNA 破坏。由于用于减轻正常细胞 DNA 损伤的化学物质会产生大量副作用，因此保护人们免受辐射的有害影响是一项具有挑战性的任务。医院仍在使用放射疗法治疗癌症，但其放射线的负面影响已超过了其带来的益处。植物营养素及其衍生物具有多种生物功能，由于在亚细胞和细胞环境中无毒，通常被认为是无害的。此外，它们还具有减轻辐射引起的损伤的能力。本综述旨在描述植物多酚和提取物的辐射防护特性，阐明它们在各种模型中的作用机制。
{"title":"REVIEW OF PHYTO-MEDICAL EXTRACTS’ AND COMPOUNDS’ ANTI-RADIATION PROPERTIES","authors":"Mwalimu Raphael Jilani, Azhagu Saravana Babu Packirisamy","doi":"10.22159/ajpcr.2024.v17i5.50248","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50248","url":null,"abstract":"Humans are routinely exposed to radiation when receiving cancer treatment, fighting nuclear weapons, exploring space, and flying. Radiation exposure damages biological components such as protein, lipids, and cell membranes because it causes oxidative stress and inflammatory mediators, which can lead to DNA destruction even at low concentrations. Protecting people from the harmful effects of radiation is a challenging task due to the plethora of side effects of the chemical compounds used to mitigate DNA damage in normal cells. Hospitals continue to utilize radiotherapy for cancer treatment; yet, the adverse effects of the radiation they emit have outweighed the benefits. Plant phytochemicals and their derivatives exhibit diverse biological functions, often perceived as innocuous due to their non-toxic nature within subcellular and cellular environments. Moreover, they possess the capability to mitigate radiation-induced damage. This review aims to delineate the radioprotective attributes of plant polyphenols and extracts, elucidating their mechanisms of action across various models.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"170 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50946
Shweta Jain, Biswas Ss, Swati Jain
Objectives: Nonalcoholic fatty liver disease is strongly linked with hepatic fatty infiltration and visceral adiposity, therefore, being a cause and a result of metabolic syndrome. The objective of the study is to find an association of metabolic syndrome (MetS) with nonalcoholic fatty liver disease (NAFLD). Methods: A total of 342 subjects from which 86 NAFLD 86 control were suitably selected for study duration of 1 year. Diagnosis of nonalcoholic fatty liver disease was done by liver imaging and based on liver enzymes. MetS assessment was done by the national cholesterol education program adult treatment panel III (NCEP ATP III) criteria. Estimation of all biochemical and hematological parameters and liver enzymes was done following standard guidelines. Mean comparison of quantitative data in different groups was analyzed with one-way analysis of variance. Results: There were significant high levels of body mass index, waist circumference, and lipid profiles in NAFLD patients in comparison to control population (p<0.001). According to the NCEP ATP III criteria, 59.3% of NAFLD were present with MetS where risk estimate was significant (odds ratio=2.15). Conclusion: This study suggests that there is an increased in all the components of MetS and gross changes in biochemical markers in cases of NAFLD. Therefore, whenever MetS factors are met in the clinical checkups, patients must be diagnosed for NAFLD by imaging (fatty liver).
目的：非酒精性脂肪肝与肝脏脂肪浸润和内脏肥胖密切相关，因此是代谢综合征的原因和结果。本研究旨在发现代谢综合征（MetS）与非酒精性脂肪肝（NAFLD）之间的关联：方法：共选取 342 名受试者进行为期一年的研究，其中 86 名为非酒精性脂肪肝患者，86 名为对照组。非酒精性脂肪肝的诊断是通过肝脏成像和肝酶进行的。MetS 评估是根据国家胆固醇教育计划成人治疗小组 III（NCEP ATP III）标准进行的。所有生化指标、血液指标和肝酶的估算均按照标准指南进行。采用单因素方差分析对不同组的定量数据进行平均比较：结果：与对照组相比，非酒精性脂肪肝患者的体重指数、腰围和血脂水平明显偏高（P<0.001）。根据 NCEP ATP III 标准，59.3% 的非酒精性脂肪肝患者伴有 MetS，其风险估计值显著（几率比=2.15）：本研究表明，在非酒精性脂肪肝病例中，MetS 的所有成分都有所增加，生化指标也发生了严重变化。因此，只要在临床检查中发现 MetS 因素，就必须通过影像学检查（脂肪肝）诊断患者是否患有非酒精性脂肪肝。
{"title":"AN ASSOCIATION OF METABOLIC SYNDROME WITH NONALCOHOLIC FATTY LIVER DISEASE","authors":"Shweta Jain, Biswas Ss, Swati Jain","doi":"10.22159/ajpcr.2024.v17i5.50946","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50946","url":null,"abstract":"Objectives: Nonalcoholic fatty liver disease is strongly linked with hepatic fatty infiltration and visceral adiposity, therefore, being a cause and a result of metabolic syndrome. The objective of the study is to find an association of metabolic syndrome (MetS) with nonalcoholic fatty liver disease (NAFLD).\u0000Methods: A total of 342 subjects from which 86 NAFLD 86 control were suitably selected for study duration of 1 year. Diagnosis of nonalcoholic fatty liver disease was done by liver imaging and based on liver enzymes. MetS assessment was done by the national cholesterol education program adult treatment panel III (NCEP ATP III) criteria. Estimation of all biochemical and hematological parameters and liver enzymes was done following standard guidelines. Mean comparison of quantitative data in different groups was analyzed with one-way analysis of variance.\u0000Results: There were significant high levels of body mass index, waist circumference, and lipid profiles in NAFLD patients in comparison to control population (p<0.001). According to the NCEP ATP III criteria, 59.3% of NAFLD were present with MetS where risk estimate was significant (odds ratio=2.15).\u0000Conclusion: This study suggests that there is an increased in all the components of MetS and gross changes in biochemical markers in cases of NAFLD. Therefore, whenever MetS factors are met in the clinical checkups, patients must be diagnosed for NAFLD by imaging (fatty liver).","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"31 s102","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50307
S. Y, S. C, R. D
Objectives: Displaced femoral neck fractures are frequently treated with bipolar hemiarthroplasties. There is little long-term data regarding bipolar hemiarthroplasty. This study aims to know the clinical efficacy of bipolar hemiarthroplasty in fractured neck femur in old age people. Patients are assessed postoperatively for pain, limp, and functional activities, and a Harris hip score is used to evaluate the results. Methods: This is a prospective study that included patients who underwent bipolar hemi replacement arthroplasty. A total 40 number of patients treated with bipolar prosthesis were assessed during our study. Both males and females were included in the study. We obtained all proper consent from patients during the study from a tertiary care hospital. Results: In this study, a sample of 20 patients with fractures of the neck of the femur with displacement, communication, and neck resorption above 50 years old were surgically treated with hemiarthroplasty using a bipolar endoprosthesis. Postoperatively, bipolar hemiarthroplasty allows for early mobilization, pain alleviation, and a high degree of activity while posing little risks. Conclusion: When compared to Austin Moore’s prosthesis, bipolar hemiarthroplasty had fewer complications, such as acetabular erosion and anterior thigh pain. As a result of these findings, we believe that bipolar hemiarthroplasty is the best treatment for intracapsular fracture neck femur.
{"title":"A PROSPECTIVE STUDY OF SURGICAL MANAGEMENT OF FRACTURE NECK OF FEMUR IN ADULTS WITH CEMENTED BIPOLAR HEMIARTHROPLASTY","authors":"S. Y, S. C, R. D","doi":"10.22159/ajpcr.2024.v17i5.50307","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50307","url":null,"abstract":"Objectives: Displaced femoral neck fractures are frequently treated with bipolar hemiarthroplasties. There is little long-term data regarding bipolar hemiarthroplasty. This study aims to know the clinical efficacy of bipolar hemiarthroplasty in fractured neck femur in old age people. Patients are assessed postoperatively for pain, limp, and functional activities, and a Harris hip score is used to evaluate the results.\u0000Methods: This is a prospective study that included patients who underwent bipolar hemi replacement arthroplasty. A total 40 number of patients treated with bipolar prosthesis were assessed during our study. Both males and females were included in the study. We obtained all proper consent from patients during the study from a tertiary care hospital.\u0000Results: In this study, a sample of 20 patients with fractures of the neck of the femur with displacement, communication, and neck resorption above 50 years old were surgically treated with hemiarthroplasty using a bipolar endoprosthesis. Postoperatively, bipolar hemiarthroplasty allows for early mobilization, pain alleviation, and a high degree of activity while posing little risks.\u0000Conclusion: When compared to Austin Moore’s prosthesis, bipolar hemiarthroplasty had fewer complications, such as acetabular erosion and anterior thigh pain. As a result of these findings, we believe that bipolar hemiarthroplasty is the best treatment for intracapsular fracture neck femur.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"23 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50236
I. Am, V. Kb, Gurram Madhan Kumar, Sujin Shanmugavelu
Objectives: Tibia fractures are the most common long bone fractures, among which diaphyseal fractures are more common. Tibial diaphyseal fractures have a significant risk of non-union and malunion among all long bone fractures. Among adults, IMILN is the treatment of choice for unstable and displaced fractures. The traditional surgical method is the infrapatellar approach, which has its own drawbacks. Here, we are studying the suprapatellar approach. Methods: The prospective study was conducted on 25 patients in the Department of Orthopedics, Government General Hospital, Kurnool for 1 year from November 2022 to November 2023. Patients were examined clinically and functional outcomes were noted. Results: The suprapatellar approach shows an average operative time was 40–80 min and blood loss was around 70–90 mL. The mean time of union was 15–16 weeks. Conclusion: For tibial diaphyseal fractures, the suprapatellar approach is a safe and effective alternative nail insertion.
{"title":"MANAGEMENT OF THE TIBIAL SHAFT FRACTURES WITH A SUPRAPATELLAR APPROACH","authors":"I. Am, V. Kb, Gurram Madhan Kumar, Sujin Shanmugavelu","doi":"10.22159/ajpcr.2024.v17i5.50236","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50236","url":null,"abstract":"Objectives: Tibia fractures are the most common long bone fractures, among which diaphyseal fractures are more common. Tibial diaphyseal fractures have a significant risk of non-union and malunion among all long bone fractures. Among adults, IMILN is the treatment of choice for unstable and displaced fractures. The traditional surgical method is the infrapatellar approach, which has its own drawbacks. Here, we are studying the suprapatellar approach.\u0000Methods: The prospective study was conducted on 25 patients in the Department of Orthopedics, Government General Hospital, Kurnool for 1 year from November 2022 to November 2023. Patients were examined clinically and functional outcomes were noted.\u0000Results: The suprapatellar approach shows an average operative time was 40–80 min and blood loss was around 70–90 mL. The mean time of union was 15–16 weeks.\u0000Conclusion: For tibial diaphyseal fractures, the suprapatellar approach is a safe and effective alternative nail insertion.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"151 S623","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.49806
P. S. Mishra, Ashutosh Tiwari, Meghna Shinde, Deepti Rastogi, Avina Kharat
Objective: The objective of the study is to assess the drug usage pattern, personal hygiene, and sanitation practices among day scholars and hosteller medical students. Methods: A questionnaire-based cross-sectional study was conducted at MGM Medical College and M.Y. Hospital, Indore. Undergraduate and postgraduate medical students who experienced episodes of diarrhea in the past 6 months were included in the study. Diarrhea occurring due to organic causes was excluded. Data were collected using a Google or physical form and were analyzed using descriptive statistics. Results: 254 students who suffered from diarrhea in the past 6 months participated in the study, out of which 56% were hostellers. Commonly used drugs were ofloxacin, metronidazole, etc. 50.2% of them took self-medication; the majority of them were hostellers. Students were found to eat outside at least once a week. Personal hygiene and sanitation were more compromised among hostellers than day scholars. Conclusion: Personal hygiene and sanitation practices should be improved among medical students, especially hostel students. These students, despite being from medical backgrounds, still take irrational medication. Therefore, there is a need for increased awareness regarding drug usage, and self-medication should be discouraged.
{"title":"A CROSS-SECTIONAL STUDY TO ASSESS THE PATTERN OF SELF-MEDICATION USED FOR DIARRHEA AMONG MEDICAL STUDENTS IN TERTIARY CARE TEACHING HOSPITAL OF CENTRAL INDIA","authors":"P. S. Mishra, Ashutosh Tiwari, Meghna Shinde, Deepti Rastogi, Avina Kharat","doi":"10.22159/ajpcr.2024.v17i5.49806","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.49806","url":null,"abstract":"Objective: The objective of the study is to assess the drug usage pattern, personal hygiene, and sanitation practices among day scholars and hosteller medical students.\u0000Methods: A questionnaire-based cross-sectional study was conducted at MGM Medical College and M.Y. Hospital, Indore. Undergraduate and postgraduate medical students who experienced episodes of diarrhea in the past 6 months were included in the study. Diarrhea occurring due to organic causes was excluded. Data were collected using a Google or physical form and were analyzed using descriptive statistics.\u0000Results: 254 students who suffered from diarrhea in the past 6 months participated in the study, out of which 56% were hostellers. Commonly used drugs were ofloxacin, metronidazole, etc. 50.2% of them took self-medication; the majority of them were hostellers. Students were found to eat outside at least once a week. Personal hygiene and sanitation were more compromised among hostellers than day scholars.\u0000Conclusion: Personal hygiene and sanitation practices should be improved among medical students, especially hostel students. These students, despite being from medical backgrounds, still take irrational medication. Therefore, there is a need for increased awareness regarding drug usage, and self-medication should be discouraged.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"101 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Awake fiberoptic intubation (AFOI) is a step-forward technique for successful intubation of patients with difficult airways. The popularity of its usage is increasing day by day in handling difficult airways. Our study aims to compare the efficacy and efficiency of Buprenorphine and Fentanyl as sedative agents for AFOI. The primary and secondary outcome measure was to assess hemodynamic response and on intubating condition of the patient after AFOI. Methods: This randomized, prospective study was conducted in tertiary Center hospital. Total of 100 patient were enrolled for study and divided into two groups, Group A patients received intravenous Buprenorphine injection (2.5 (microgram/kilogram [μg/kg] over 10 min) and Group B Fentanyl injection (2 μg/kg over10 min) was injected prior to AFOI. The degree of sedation was assessed using the Observer’s assessment of alertness/sedation score (OAA/S), and the score of coughing during awake bronchoscopy was used to assess intubation status. Tolerability of intubation was assessed using a 5-point intubation score and a 3-point post-intubation assessment score immediately after the placement of the endotracheal tube into the trachea. Results: Group A had more favorable OAA score than Group B, whereas other intubation conditions cough score, limb movement, 5-point intubation score, 3-point post intubation score was more favourable in Group B than in Group A. Conclusion: Intravenous Fentanyl is better than Buprenorphine agent in terms of intubation score for AFOI. Both groups are comparable in terms of hemodynamic changes and stability.
{"title":"RANDOMIZED TRIAL FOR COMPARISON OF BUPRENORPHINE AND FENTANYL FOR AWAKE FIBEROPTIC INTUBATION","authors":"Gaurav Goyal, Kiran Yadav, Kalpana Verma, Namita Gupta, Sudhir Sachdeva","doi":"10.22159/ajpcr.2024.v17i5.50676","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50676","url":null,"abstract":"Objectives: Awake fiberoptic intubation (AFOI) is a step-forward technique for successful intubation of patients with difficult airways. The popularity of its usage is increasing day by day in handling difficult airways. Our study aims to compare the efficacy and efficiency of Buprenorphine and Fentanyl as sedative agents for AFOI. The primary and secondary outcome measure was to assess hemodynamic response and on intubating condition of the patient after AFOI.\u0000Methods: This randomized, prospective study was conducted in tertiary Center hospital. Total of 100 patient were enrolled for study and divided into two groups, Group A patients received intravenous Buprenorphine injection (2.5 (microgram/kilogram [μg/kg] over 10 min) and Group B Fentanyl injection (2 μg/kg over10 min) was injected prior to AFOI. The degree of sedation was assessed using the Observer’s assessment of alertness/sedation score (OAA/S), and the score of coughing during awake bronchoscopy was used to assess intubation status. Tolerability of intubation was assessed using a 5-point intubation score and a 3-point post-intubation assessment score immediately after the placement of the endotracheal tube into the trachea.\u0000Results: Group A had more favorable OAA score than Group B, whereas other intubation conditions cough score, limb movement, 5-point intubation score, 3-point post intubation score was more favourable in Group B than in Group A.\u0000Conclusion: Intravenous Fentanyl is better than Buprenorphine agent in terms of intubation score for AFOI. Both groups are comparable in terms of hemodynamic changes and stability.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.49025
Ajay Paul, Athulya G. Asokan
Objectives: (1) The objective of this study was to determine the frequency of sexual dysfunction (SD) among patients with Type 2 diabetes mellitus attending the General Medicine and Endocrinology Department at a tertiary care center in south Kerala. (2) To assess the relationship between erectile dysfunction and the microvascular consequences of Type 2 diabetes. (3) To correlate SD with glycemic status. Methods: One hundred and twenty patients with Type 2 diabetes at a tertiary care center in south Kerala participated in the cross-sectional study. A questionnaire was employed to document demographic and glycemic status. The assessment tools utilized included the International Index of Erectile Function for male and the Female Sexual Function Index (FSFI) scoring questionnaire for females. The statistical analysis employed included unpaired t-tests for students and tests assessing the equality of proportions. Results: About 65% of patients with diabetes mellitus had SD. About 46% of female participants and 78.6% of male participants in the study population had SD. Duration of diabetes, poor glycemic status, and microvascular complications correlated with SD. Conclusion: SD is frequent in patients with Type 2 diabetes mellitus. Glycemic control determines the development of SD. It is advisable to screen patients with Type 2 diabetes mellitus for SD as a proactive measure for early intervention and management.
{"title":"DIABETES-RELATED SEXUAL DYSFUNCTION AND ITS ASSOCIATION WITH MICROVASCULAR COMPLICATIONS: A STUDY FROM TERTIARY CARE CENTER IN SOUTH KERALA","authors":"Ajay Paul, Athulya G. Asokan","doi":"10.22159/ajpcr.2024.v17i5.49025","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.49025","url":null,"abstract":"Objectives: (1) The objective of this study was to determine the frequency of sexual dysfunction (SD) among patients with Type 2 diabetes mellitus attending the General Medicine and Endocrinology Department at a tertiary care center in south Kerala. (2) To assess the relationship between erectile dysfunction and the microvascular consequences of Type 2 diabetes. (3) To correlate SD with glycemic status.\u0000Methods: One hundred and twenty patients with Type 2 diabetes at a tertiary care center in south Kerala participated in the cross-sectional study. A questionnaire was employed to document demographic and glycemic status. The assessment tools utilized included the International Index of Erectile Function for male and the Female Sexual Function Index (FSFI) scoring questionnaire for females. The statistical analysis employed included unpaired t-tests for students and tests assessing the equality of proportions.\u0000Results: About 65% of patients with diabetes mellitus had SD. About 46% of female participants and 78.6% of male participants in the study population had SD. Duration of diabetes, poor glycemic status, and microvascular complications correlated with SD.\u0000Conclusion: SD is frequent in patients with Type 2 diabetes mellitus. Glycemic control determines the development of SD. It is advisable to screen patients with Type 2 diabetes mellitus for SD as a proactive measure for early intervention and management.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50431
Shweta Mishra, Sunil Kumar Shah, Dubey Bk
Objective: This experiment aimed to improve the bioavailability of terbutaline sulfate by formulating it as medicated chewing gum. Methods: By employing zein as the gum foundation and the melting process, chewing gum was created with the desired outcome. Results: All formulations had thicknesses ranging from 3.61 to 3.68 mm in the lateral direction and from 5.22 to 5.41 mm in the longitudinal direction. All formulations had hardness values between 3.1 and 3.4 kg/cm2. All formulations had weight variations between 1.6% and 2.1%. All of the formulations had the same quantity of medication, which varied between 95.2 and 96.9%. Drug release from terbutaline sulfate chewing gum (TCGs) in simulated saliva (pH 6.8 buffer solution) was investigated by examining the samples up to a half-hour later. It was discovered that the drug release from the formulations ranged from 64.28 to 89.56% in 30 min. Conclusion: The release of the medication was reduced when the gum basis (zein) content in the formulations was increased. It was discovered that, after 30 min, TCG1 emitted the most proportion of terbutaline sulfate. As a result, it may be regarded as the finest formulation available.
{"title":"FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF TERBUTALINE SULFATE FOR THE ASTHAMATIC MANAGEMENT","authors":"Shweta Mishra, Sunil Kumar Shah, Dubey Bk","doi":"10.22159/ajpcr.2024.v17i5.50431","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50431","url":null,"abstract":"Objective: This experiment aimed to improve the bioavailability of terbutaline sulfate by formulating it as medicated chewing gum.\u0000Methods: By employing zein as the gum foundation and the melting process, chewing gum was created with the desired outcome.\u0000Results: All formulations had thicknesses ranging from 3.61 to 3.68 mm in the lateral direction and from 5.22 to 5.41 mm in the longitudinal direction. All formulations had hardness values between 3.1 and 3.4 kg/cm2. All formulations had weight variations between 1.6% and 2.1%. All of the formulations had the same quantity of medication, which varied between 95.2 and 96.9%. Drug release from terbutaline sulfate chewing gum (TCGs) in simulated saliva (pH 6.8 buffer solution) was investigated by examining the samples up to a half-hour later. It was discovered that the drug release from the formulations ranged from 64.28 to 89.56% in 30 min.\u0000Conclusion: The release of the medication was reduced when the gum basis (zein) content in the formulations was increased. It was discovered that, after 30 min, TCG1 emitted the most proportion of terbutaline sulfate. As a result, it may be regarded as the finest formulation available.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"30 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Donor recruitment is critical to the supply of safe and adequate blood/blood components to meet patient’s need; the first and most crucial step to provide safe blood is proper selection of blood donors. Blood donor selection criteria are designed to ensure the donor as well as the recipient’s health. The objective of this study is to analyze the various causes of donor deferral, study their frequency pattern and to suggest changes to retain and retrieve donors in future. Methods: A retrospective study on analysis of deferred donors of whole blood was conducted in a blood center at tertiary care hospital in North India. The study included blood donors deferred from January 2022 to December 2022. Results: A total of 27,121 donors were registered for whole blood donation and 4534 (16.71%) were deferred. Female deferral (41.67%) was more as compared to male deferral (15.11%). Temporary deferrals (n=4238 [93.47%]) were significantly higher than permanent deferrals (n=296 [6.5%]). The most common reason for temporary deferral was anemia (n = 940 [20.7%]) while that for permanent deferral was jaundice (n=179 [3.94%]). Conclusion: Analyzing the causes, frequency and deferral pattern of blood donors will help to guide the recruitment and retention efforts to maintain a healthy donor pool at large.
{"title":"THE EVALUATION OF PATTERN OF WHOLE BLOOD DONOR DEFERRALS IN A TERTIARY CARE CENTER OF NORTH INDIA","authors":"Rajni Bassi, Poonam Singal, Liveleen Kaur, Urvashi Kapoor, Sukriti Bansal","doi":"10.22159/ajpcr.2024.v17i5.50314","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50314","url":null,"abstract":"Objectives: Donor recruitment is critical to the supply of safe and adequate blood/blood components to meet patient’s need; the first and most crucial step to provide safe blood is proper selection of blood donors. Blood donor selection criteria are designed to ensure the donor as well as the recipient’s health. The objective of this study is to analyze the various causes of donor deferral, study their frequency pattern and to suggest changes to retain and retrieve donors in future.\u0000Methods: A retrospective study on analysis of deferred donors of whole blood was conducted in a blood center at tertiary care hospital in North India. The study included blood donors deferred from January 2022 to December 2022.\u0000Results: A total of 27,121 donors were registered for whole blood donation and 4534 (16.71%) were deferred. Female deferral (41.67%) was more as compared to male deferral (15.11%). Temporary deferrals (n=4238 [93.47%]) were significantly higher than permanent deferrals (n=296 [6.5%]). The most common reason for temporary deferral was anemia (n = 940 [20.7%]) while that for permanent deferral was jaundice (n=179 [3.94%]).\u0000Conclusion: Analyzing the causes, frequency and deferral pattern of blood donors will help to guide the recruitment and retention efforts to maintain a healthy donor pool at large.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"21 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50981
Kamaldeep Kaur, Deep Inder Singh, Amita
Objectives: Poor cardiovascular outcomes have been linked to high-sensitivity C-reaction protein (hs-CRP), a biomarker of residual inflammatory risk. Whether or not a patient has diabetes mellitus, evaluate the relationship among hs-CRP levels estimated at hospital admission and in-hospital consequences and death. Methods: This prospective cohort study included 100 acute myocardial infarction (AMI) patients with both non-ST elevation myocardial infarction (STEMI) and STEMI who were admitted to the cardiac care critical care unit intensive therapy unit. Results: Diabetics had a considerably higher incidence of hypertension (p=0.001) and dyslipidemia (p=0.001) compared to non-diabetics. Diabetics exhibited a significantly higher mean hs-CRP level (6.76±1.12 vs. 3.65±0.98 mg/dL; p=0.01) than non-diabetics. Meanwhile, compared to non-diabetics, diabetics utilized significantly more aspirin (p=0.001), beta-blockers (p=0.001), angiotensin receptor blockers (ARBs) (p=0.01), and statins (p=0.001). Furthermore, compared to those with hs-CRP <3 mg/L, those with hs-CRP ≥3 mg/dL had a significantly higher incidence of dyslipidemia (p=0.001) and hypertension (p=0.001). Conclusion: The results of the current study demonstrated that hs-CRP upon admission is a valid predictor of hospital morbidity and death in patients with AMI who are diabetic or non-diabetic. Individuals with diabetes showed greater CRP levels than non-diabetic AMI patients did.
目的：心血管疾病的不良后果与高敏C反应蛋白（hs-CRP）有关，这是一种残留炎症风险的生物标志物。无论患者是否患有糖尿病，都要评估入院时估计的 hs-CRP 水平与院内后果和死亡之间的关系：这项前瞻性队列研究纳入了 100 名急性心肌梗死（AMI）患者，这些患者既有非 ST 期抬高型心肌梗死（STEMI），也有 STEMI，他们都住进了心脏护理重症监护室的强化治疗病房：与非糖尿病患者相比，糖尿病患者的高血压（P=0.001）和血脂异常（P=0.001）发生率要高得多。糖尿病患者的 hs-CRP 平均水平（6.76±1.12 vs. 3.65±0.98 mg/dL；p=0.01）明显高于非糖尿病患者。同时，与非糖尿病患者相比，糖尿病患者使用阿司匹林（p=0.001）、β-受体阻滞剂（p=0.001）、血管紧张素受体阻滞剂（ARBs）（p=0.01）和他汀类药物（p=0.001）的比例明显更高。此外，与 hs-CRP <3 mg/L 的患者相比，hs-CRP ≥3 mg/dL 的患者血脂异常（p=0.001）和高血压（p=0.001）的发生率明显更高：本研究结果表明，入院时的hs-CRP可有效预测糖尿病或非糖尿病急性心肌梗死患者的住院发病率和死亡率。糖尿病患者的 CRP 水平高于非糖尿病 AMI 患者。
{"title":"CLINICAL RELEVANCE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN ACUTE MYOCARDIAL INFARCTION PATIENTS","authors":"Kamaldeep Kaur, Deep Inder Singh, Amita","doi":"10.22159/ajpcr.2024.v17i5.50981","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50981","url":null,"abstract":"Objectives: Poor cardiovascular outcomes have been linked to high-sensitivity C-reaction protein (hs-CRP), a biomarker of residual inflammatory risk. Whether or not a patient has diabetes mellitus, evaluate the relationship among hs-CRP levels estimated at hospital admission and in-hospital consequences and death.\u0000Methods: This prospective cohort study included 100 acute myocardial infarction (AMI) patients with both non-ST elevation myocardial infarction (STEMI) and STEMI who were admitted to the cardiac care critical care unit intensive therapy unit.\u0000Results: Diabetics had a considerably higher incidence of hypertension (p=0.001) and dyslipidemia (p=0.001) compared to non-diabetics. Diabetics exhibited a significantly higher mean hs-CRP level (6.76±1.12 vs. 3.65±0.98 mg/dL; p=0.01) than non-diabetics. Meanwhile, compared to non-diabetics, diabetics utilized significantly more aspirin (p=0.001), beta-blockers (p=0.001), angiotensin receptor blockers (ARBs) (p=0.01), and statins (p=0.001). Furthermore, compared to those with hs-CRP <3 mg/L, those with hs-CRP ≥3 mg/dL had a significantly higher incidence of dyslipidemia (p=0.001) and hypertension (p=0.001).\u0000Conclusion: The results of the current study demonstrated that hs-CRP upon admission is a valid predictor of hospital morbidity and death in patients with AMI who are diabetic or non-diabetic. Individuals with diabetes showed greater CRP levels than non-diabetic AMI patients did.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"85 s375","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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