Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.51180
Aniruddha Mazumder, Reena Kumari, D. Bhagat
To report a case of bilateral papilledema due to underlying transitional meningioma in left occipital lobe in a 30-year-old female.
报告一例因左枕叶潜在过渡性脑膜瘤导致的双侧乳头水肿病例，患者女性，30 岁。
{"title":"BILATERAL PAPILLEDEMA DUE TO UNDERLYING OCCIPITAL LOBE TRANSITIONAL MENINGIOMA","authors":"Aniruddha Mazumder, Reena Kumari, D. Bhagat","doi":"10.22159/ajpcr.2024.v17i5.51180","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.51180","url":null,"abstract":"To report a case of bilateral papilledema due to underlying transitional meningioma in left occipital lobe in a 30-year-old female.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"63 S289","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50419
Ajay Chhabra, Saloni Khattar, P. Bagga
Hemophagocytic lymphohistiocytosis (HLH) is a rare, yet potentially fatal disorder of uncontrolled inflammation and dysregulated immunity. Patients may present with features ranging from fever, rash, and cytopenias to fatal multiorgan failure. Here, we present a case series reporting four cases of HLH, their clinicopathological findings, laboratory investigations, and outcomes. The underlying causes for the four cases were found to be infective ones, i.e., Leptospira, hepatitis-E and herpes simplex virus-1, kala-azar and malaria and enteric fever. HLH is a manifestation of the dysregulated immune response of various T cells leading to cytokinemia causing an accumulation of macrophages and T lymphocytes in various tissues. Infections account for about half of all HLH cases in adults the world over. In our institute, infections may still be more prevalent as a cause. Moreover, this may be the scenario in our country where infectious diseases remain a major proportion of the disease burden.
嗜血细胞淋巴组织细胞增多症（HLH）是一种罕见的、但可能致命的炎症失控和免疫失调性疾病。患者可表现出从发热、皮疹、细胞减少症到致命的多器官功能衰竭等各种特征。在此，我们报告了四例 HLH 病例、其临床病理结果、实验室检查和预后。这四例病例的病因均为感染性病因，即钩端螺旋体、戊型肝炎、单纯疱疹病毒-1、卡阿拉扎病、疟疾和肠道热。HLH 是各种 T 细胞免疫反应失调的一种表现，导致细胞因子血症，造成巨噬细胞和 T 淋巴细胞在各种组织中聚集。感染约占全世界成人 HLH 病例的一半。在我院，感染可能仍然是更常见的病因。此外，在我国，感染性疾病仍然是疾病负担的主要部分，情况可能也是如此。
{"title":"INFECTIOUS DISEASES COMPLICATED BY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS – A RARE CASE SERIES","authors":"Ajay Chhabra, Saloni Khattar, P. Bagga","doi":"10.22159/ajpcr.2024.v17i5.50419","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50419","url":null,"abstract":"Hemophagocytic lymphohistiocytosis (HLH) is a rare, yet potentially fatal disorder of uncontrolled inflammation and dysregulated immunity. Patients may present with features ranging from fever, rash, and cytopenias to fatal multiorgan failure. Here, we present a case series reporting four cases of HLH, their clinicopathological findings, laboratory investigations, and outcomes. The underlying causes for the four cases were found to be infective ones, i.e., Leptospira, hepatitis-E and herpes simplex virus-1, kala-azar and malaria and enteric fever. HLH is a manifestation of the dysregulated immune response of various T cells leading to cytokinemia causing an accumulation of macrophages and T lymphocytes in various tissues. Infections account for about half of all HLH cases in adults the world over. In our institute, infections may still be more prevalent as a cause. Moreover, this may be the scenario in our country where infectious diseases remain a major proportion of the disease burden.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"27 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50307
S. Y, S. C, R. D
Objectives: Displaced femoral neck fractures are frequently treated with bipolar hemiarthroplasties. There is little long-term data regarding bipolar hemiarthroplasty. This study aims to know the clinical efficacy of bipolar hemiarthroplasty in fractured neck femur in old age people. Patients are assessed postoperatively for pain, limp, and functional activities, and a Harris hip score is used to evaluate the results. Methods: This is a prospective study that included patients who underwent bipolar hemi replacement arthroplasty. A total 40 number of patients treated with bipolar prosthesis were assessed during our study. Both males and females were included in the study. We obtained all proper consent from patients during the study from a tertiary care hospital. Results: In this study, a sample of 20 patients with fractures of the neck of the femur with displacement, communication, and neck resorption above 50 years old were surgically treated with hemiarthroplasty using a bipolar endoprosthesis. Postoperatively, bipolar hemiarthroplasty allows for early mobilization, pain alleviation, and a high degree of activity while posing little risks. Conclusion: When compared to Austin Moore’s prosthesis, bipolar hemiarthroplasty had fewer complications, such as acetabular erosion and anterior thigh pain. As a result of these findings, we believe that bipolar hemiarthroplasty is the best treatment for intracapsular fracture neck femur.
{"title":"A PROSPECTIVE STUDY OF SURGICAL MANAGEMENT OF FRACTURE NECK OF FEMUR IN ADULTS WITH CEMENTED BIPOLAR HEMIARTHROPLASTY","authors":"S. Y, S. C, R. D","doi":"10.22159/ajpcr.2024.v17i5.50307","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50307","url":null,"abstract":"Objectives: Displaced femoral neck fractures are frequently treated with bipolar hemiarthroplasties. There is little long-term data regarding bipolar hemiarthroplasty. This study aims to know the clinical efficacy of bipolar hemiarthroplasty in fractured neck femur in old age people. Patients are assessed postoperatively for pain, limp, and functional activities, and a Harris hip score is used to evaluate the results.\u0000Methods: This is a prospective study that included patients who underwent bipolar hemi replacement arthroplasty. A total 40 number of patients treated with bipolar prosthesis were assessed during our study. Both males and females were included in the study. We obtained all proper consent from patients during the study from a tertiary care hospital.\u0000Results: In this study, a sample of 20 patients with fractures of the neck of the femur with displacement, communication, and neck resorption above 50 years old were surgically treated with hemiarthroplasty using a bipolar endoprosthesis. Postoperatively, bipolar hemiarthroplasty allows for early mobilization, pain alleviation, and a high degree of activity while posing little risks.\u0000Conclusion: When compared to Austin Moore’s prosthesis, bipolar hemiarthroplasty had fewer complications, such as acetabular erosion and anterior thigh pain. As a result of these findings, we believe that bipolar hemiarthroplasty is the best treatment for intracapsular fracture neck femur.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"23 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50236
I. Am, V. Kb, Gurram Madhan Kumar, Sujin Shanmugavelu
Objectives: Tibia fractures are the most common long bone fractures, among which diaphyseal fractures are more common. Tibial diaphyseal fractures have a significant risk of non-union and malunion among all long bone fractures. Among adults, IMILN is the treatment of choice for unstable and displaced fractures. The traditional surgical method is the infrapatellar approach, which has its own drawbacks. Here, we are studying the suprapatellar approach. Methods: The prospective study was conducted on 25 patients in the Department of Orthopedics, Government General Hospital, Kurnool for 1 year from November 2022 to November 2023. Patients were examined clinically and functional outcomes were noted. Results: The suprapatellar approach shows an average operative time was 40–80 min and blood loss was around 70–90 mL. The mean time of union was 15–16 weeks. Conclusion: For tibial diaphyseal fractures, the suprapatellar approach is a safe and effective alternative nail insertion.
{"title":"MANAGEMENT OF THE TIBIAL SHAFT FRACTURES WITH A SUPRAPATELLAR APPROACH","authors":"I. Am, V. Kb, Gurram Madhan Kumar, Sujin Shanmugavelu","doi":"10.22159/ajpcr.2024.v17i5.50236","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50236","url":null,"abstract":"Objectives: Tibia fractures are the most common long bone fractures, among which diaphyseal fractures are more common. Tibial diaphyseal fractures have a significant risk of non-union and malunion among all long bone fractures. Among adults, IMILN is the treatment of choice for unstable and displaced fractures. The traditional surgical method is the infrapatellar approach, which has its own drawbacks. Here, we are studying the suprapatellar approach.\u0000Methods: The prospective study was conducted on 25 patients in the Department of Orthopedics, Government General Hospital, Kurnool for 1 year from November 2022 to November 2023. Patients were examined clinically and functional outcomes were noted.\u0000Results: The suprapatellar approach shows an average operative time was 40–80 min and blood loss was around 70–90 mL. The mean time of union was 15–16 weeks.\u0000Conclusion: For tibial diaphyseal fractures, the suprapatellar approach is a safe and effective alternative nail insertion.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"151 S623","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.49806
P. S. Mishra, Ashutosh Tiwari, Meghna Shinde, Deepti Rastogi, Avina Kharat
Objective: The objective of the study is to assess the drug usage pattern, personal hygiene, and sanitation practices among day scholars and hosteller medical students. Methods: A questionnaire-based cross-sectional study was conducted at MGM Medical College and M.Y. Hospital, Indore. Undergraduate and postgraduate medical students who experienced episodes of diarrhea in the past 6 months were included in the study. Diarrhea occurring due to organic causes was excluded. Data were collected using a Google or physical form and were analyzed using descriptive statistics. Results: 254 students who suffered from diarrhea in the past 6 months participated in the study, out of which 56% were hostellers. Commonly used drugs were ofloxacin, metronidazole, etc. 50.2% of them took self-medication; the majority of them were hostellers. Students were found to eat outside at least once a week. Personal hygiene and sanitation were more compromised among hostellers than day scholars. Conclusion: Personal hygiene and sanitation practices should be improved among medical students, especially hostel students. These students, despite being from medical backgrounds, still take irrational medication. Therefore, there is a need for increased awareness regarding drug usage, and self-medication should be discouraged.
{"title":"A CROSS-SECTIONAL STUDY TO ASSESS THE PATTERN OF SELF-MEDICATION USED FOR DIARRHEA AMONG MEDICAL STUDENTS IN TERTIARY CARE TEACHING HOSPITAL OF CENTRAL INDIA","authors":"P. S. Mishra, Ashutosh Tiwari, Meghna Shinde, Deepti Rastogi, Avina Kharat","doi":"10.22159/ajpcr.2024.v17i5.49806","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.49806","url":null,"abstract":"Objective: The objective of the study is to assess the drug usage pattern, personal hygiene, and sanitation practices among day scholars and hosteller medical students.\u0000Methods: A questionnaire-based cross-sectional study was conducted at MGM Medical College and M.Y. Hospital, Indore. Undergraduate and postgraduate medical students who experienced episodes of diarrhea in the past 6 months were included in the study. Diarrhea occurring due to organic causes was excluded. Data were collected using a Google or physical form and were analyzed using descriptive statistics.\u0000Results: 254 students who suffered from diarrhea in the past 6 months participated in the study, out of which 56% were hostellers. Commonly used drugs were ofloxacin, metronidazole, etc. 50.2% of them took self-medication; the majority of them were hostellers. Students were found to eat outside at least once a week. Personal hygiene and sanitation were more compromised among hostellers than day scholars.\u0000Conclusion: Personal hygiene and sanitation practices should be improved among medical students, especially hostel students. These students, despite being from medical backgrounds, still take irrational medication. Therefore, there is a need for increased awareness regarding drug usage, and self-medication should be discouraged.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"101 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Awake fiberoptic intubation (AFOI) is a step-forward technique for successful intubation of patients with difficult airways. The popularity of its usage is increasing day by day in handling difficult airways. Our study aims to compare the efficacy and efficiency of Buprenorphine and Fentanyl as sedative agents for AFOI. The primary and secondary outcome measure was to assess hemodynamic response and on intubating condition of the patient after AFOI. Methods: This randomized, prospective study was conducted in tertiary Center hospital. Total of 100 patient were enrolled for study and divided into two groups, Group A patients received intravenous Buprenorphine injection (2.5 (microgram/kilogram [μg/kg] over 10 min) and Group B Fentanyl injection (2 μg/kg over10 min) was injected prior to AFOI. The degree of sedation was assessed using the Observer’s assessment of alertness/sedation score (OAA/S), and the score of coughing during awake bronchoscopy was used to assess intubation status. Tolerability of intubation was assessed using a 5-point intubation score and a 3-point post-intubation assessment score immediately after the placement of the endotracheal tube into the trachea. Results: Group A had more favorable OAA score than Group B, whereas other intubation conditions cough score, limb movement, 5-point intubation score, 3-point post intubation score was more favourable in Group B than in Group A. Conclusion: Intravenous Fentanyl is better than Buprenorphine agent in terms of intubation score for AFOI. Both groups are comparable in terms of hemodynamic changes and stability.
{"title":"RANDOMIZED TRIAL FOR COMPARISON OF BUPRENORPHINE AND FENTANYL FOR AWAKE FIBEROPTIC INTUBATION","authors":"Gaurav Goyal, Kiran Yadav, Kalpana Verma, Namita Gupta, Sudhir Sachdeva","doi":"10.22159/ajpcr.2024.v17i5.50676","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50676","url":null,"abstract":"Objectives: Awake fiberoptic intubation (AFOI) is a step-forward technique for successful intubation of patients with difficult airways. The popularity of its usage is increasing day by day in handling difficult airways. Our study aims to compare the efficacy and efficiency of Buprenorphine and Fentanyl as sedative agents for AFOI. The primary and secondary outcome measure was to assess hemodynamic response and on intubating condition of the patient after AFOI.\u0000Methods: This randomized, prospective study was conducted in tertiary Center hospital. Total of 100 patient were enrolled for study and divided into two groups, Group A patients received intravenous Buprenorphine injection (2.5 (microgram/kilogram [μg/kg] over 10 min) and Group B Fentanyl injection (2 μg/kg over10 min) was injected prior to AFOI. The degree of sedation was assessed using the Observer’s assessment of alertness/sedation score (OAA/S), and the score of coughing during awake bronchoscopy was used to assess intubation status. Tolerability of intubation was assessed using a 5-point intubation score and a 3-point post-intubation assessment score immediately after the placement of the endotracheal tube into the trachea.\u0000Results: Group A had more favorable OAA score than Group B, whereas other intubation conditions cough score, limb movement, 5-point intubation score, 3-point post intubation score was more favourable in Group B than in Group A.\u0000Conclusion: Intravenous Fentanyl is better than Buprenorphine agent in terms of intubation score for AFOI. Both groups are comparable in terms of hemodynamic changes and stability.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.49025
Ajay Paul, Athulya G. Asokan
Objectives: (1) The objective of this study was to determine the frequency of sexual dysfunction (SD) among patients with Type 2 diabetes mellitus attending the General Medicine and Endocrinology Department at a tertiary care center in south Kerala. (2) To assess the relationship between erectile dysfunction and the microvascular consequences of Type 2 diabetes. (3) To correlate SD with glycemic status. Methods: One hundred and twenty patients with Type 2 diabetes at a tertiary care center in south Kerala participated in the cross-sectional study. A questionnaire was employed to document demographic and glycemic status. The assessment tools utilized included the International Index of Erectile Function for male and the Female Sexual Function Index (FSFI) scoring questionnaire for females. The statistical analysis employed included unpaired t-tests for students and tests assessing the equality of proportions. Results: About 65% of patients with diabetes mellitus had SD. About 46% of female participants and 78.6% of male participants in the study population had SD. Duration of diabetes, poor glycemic status, and microvascular complications correlated with SD. Conclusion: SD is frequent in patients with Type 2 diabetes mellitus. Glycemic control determines the development of SD. It is advisable to screen patients with Type 2 diabetes mellitus for SD as a proactive measure for early intervention and management.
{"title":"DIABETES-RELATED SEXUAL DYSFUNCTION AND ITS ASSOCIATION WITH MICROVASCULAR COMPLICATIONS: A STUDY FROM TERTIARY CARE CENTER IN SOUTH KERALA","authors":"Ajay Paul, Athulya G. Asokan","doi":"10.22159/ajpcr.2024.v17i5.49025","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.49025","url":null,"abstract":"Objectives: (1) The objective of this study was to determine the frequency of sexual dysfunction (SD) among patients with Type 2 diabetes mellitus attending the General Medicine and Endocrinology Department at a tertiary care center in south Kerala. (2) To assess the relationship between erectile dysfunction and the microvascular consequences of Type 2 diabetes. (3) To correlate SD with glycemic status.\u0000Methods: One hundred and twenty patients with Type 2 diabetes at a tertiary care center in south Kerala participated in the cross-sectional study. A questionnaire was employed to document demographic and glycemic status. The assessment tools utilized included the International Index of Erectile Function for male and the Female Sexual Function Index (FSFI) scoring questionnaire for females. The statistical analysis employed included unpaired t-tests for students and tests assessing the equality of proportions.\u0000Results: About 65% of patients with diabetes mellitus had SD. About 46% of female participants and 78.6% of male participants in the study population had SD. Duration of diabetes, poor glycemic status, and microvascular complications correlated with SD.\u0000Conclusion: SD is frequent in patients with Type 2 diabetes mellitus. Glycemic control determines the development of SD. It is advisable to screen patients with Type 2 diabetes mellitus for SD as a proactive measure for early intervention and management.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50431
Shweta Mishra, Sunil Kumar Shah, Dubey Bk
Objective: This experiment aimed to improve the bioavailability of terbutaline sulfate by formulating it as medicated chewing gum. Methods: By employing zein as the gum foundation and the melting process, chewing gum was created with the desired outcome. Results: All formulations had thicknesses ranging from 3.61 to 3.68 mm in the lateral direction and from 5.22 to 5.41 mm in the longitudinal direction. All formulations had hardness values between 3.1 and 3.4 kg/cm2. All formulations had weight variations between 1.6% and 2.1%. All of the formulations had the same quantity of medication, which varied between 95.2 and 96.9%. Drug release from terbutaline sulfate chewing gum (TCGs) in simulated saliva (pH 6.8 buffer solution) was investigated by examining the samples up to a half-hour later. It was discovered that the drug release from the formulations ranged from 64.28 to 89.56% in 30 min. Conclusion: The release of the medication was reduced when the gum basis (zein) content in the formulations was increased. It was discovered that, after 30 min, TCG1 emitted the most proportion of terbutaline sulfate. As a result, it may be regarded as the finest formulation available.
{"title":"FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF TERBUTALINE SULFATE FOR THE ASTHAMATIC MANAGEMENT","authors":"Shweta Mishra, Sunil Kumar Shah, Dubey Bk","doi":"10.22159/ajpcr.2024.v17i5.50431","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50431","url":null,"abstract":"Objective: This experiment aimed to improve the bioavailability of terbutaline sulfate by formulating it as medicated chewing gum.\u0000Methods: By employing zein as the gum foundation and the melting process, chewing gum was created with the desired outcome.\u0000Results: All formulations had thicknesses ranging from 3.61 to 3.68 mm in the lateral direction and from 5.22 to 5.41 mm in the longitudinal direction. All formulations had hardness values between 3.1 and 3.4 kg/cm2. All formulations had weight variations between 1.6% and 2.1%. All of the formulations had the same quantity of medication, which varied between 95.2 and 96.9%. Drug release from terbutaline sulfate chewing gum (TCGs) in simulated saliva (pH 6.8 buffer solution) was investigated by examining the samples up to a half-hour later. It was discovered that the drug release from the formulations ranged from 64.28 to 89.56% in 30 min.\u0000Conclusion: The release of the medication was reduced when the gum basis (zein) content in the formulations was increased. It was discovered that, after 30 min, TCG1 emitted the most proportion of terbutaline sulfate. As a result, it may be regarded as the finest formulation available.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"30 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Donor recruitment is critical to the supply of safe and adequate blood/blood components to meet patient’s need; the first and most crucial step to provide safe blood is proper selection of blood donors. Blood donor selection criteria are designed to ensure the donor as well as the recipient’s health. The objective of this study is to analyze the various causes of donor deferral, study their frequency pattern and to suggest changes to retain and retrieve donors in future. Methods: A retrospective study on analysis of deferred donors of whole blood was conducted in a blood center at tertiary care hospital in North India. The study included blood donors deferred from January 2022 to December 2022. Results: A total of 27,121 donors were registered for whole blood donation and 4534 (16.71%) were deferred. Female deferral (41.67%) was more as compared to male deferral (15.11%). Temporary deferrals (n=4238 [93.47%]) were significantly higher than permanent deferrals (n=296 [6.5%]). The most common reason for temporary deferral was anemia (n = 940 [20.7%]) while that for permanent deferral was jaundice (n=179 [3.94%]). Conclusion: Analyzing the causes, frequency and deferral pattern of blood donors will help to guide the recruitment and retention efforts to maintain a healthy donor pool at large.
{"title":"THE EVALUATION OF PATTERN OF WHOLE BLOOD DONOR DEFERRALS IN A TERTIARY CARE CENTER OF NORTH INDIA","authors":"Rajni Bassi, Poonam Singal, Liveleen Kaur, Urvashi Kapoor, Sukriti Bansal","doi":"10.22159/ajpcr.2024.v17i5.50314","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50314","url":null,"abstract":"Objectives: Donor recruitment is critical to the supply of safe and adequate blood/blood components to meet patient’s need; the first and most crucial step to provide safe blood is proper selection of blood donors. Blood donor selection criteria are designed to ensure the donor as well as the recipient’s health. The objective of this study is to analyze the various causes of donor deferral, study their frequency pattern and to suggest changes to retain and retrieve donors in future.\u0000Methods: A retrospective study on analysis of deferred donors of whole blood was conducted in a blood center at tertiary care hospital in North India. The study included blood donors deferred from January 2022 to December 2022.\u0000Results: A total of 27,121 donors were registered for whole blood donation and 4534 (16.71%) were deferred. Female deferral (41.67%) was more as compared to male deferral (15.11%). Temporary deferrals (n=4238 [93.47%]) were significantly higher than permanent deferrals (n=296 [6.5%]). The most common reason for temporary deferral was anemia (n = 940 [20.7%]) while that for permanent deferral was jaundice (n=179 [3.94%]).\u0000Conclusion: Analyzing the causes, frequency and deferral pattern of blood donors will help to guide the recruitment and retention efforts to maintain a healthy donor pool at large.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"21 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.22159/ajpcr.2024.v17i5.50981
Kamaldeep Kaur, Deep Inder Singh, Amita
Objectives: Poor cardiovascular outcomes have been linked to high-sensitivity C-reaction protein (hs-CRP), a biomarker of residual inflammatory risk. Whether or not a patient has diabetes mellitus, evaluate the relationship among hs-CRP levels estimated at hospital admission and in-hospital consequences and death. Methods: This prospective cohort study included 100 acute myocardial infarction (AMI) patients with both non-ST elevation myocardial infarction (STEMI) and STEMI who were admitted to the cardiac care critical care unit intensive therapy unit. Results: Diabetics had a considerably higher incidence of hypertension (p=0.001) and dyslipidemia (p=0.001) compared to non-diabetics. Diabetics exhibited a significantly higher mean hs-CRP level (6.76±1.12 vs. 3.65±0.98 mg/dL; p=0.01) than non-diabetics. Meanwhile, compared to non-diabetics, diabetics utilized significantly more aspirin (p=0.001), beta-blockers (p=0.001), angiotensin receptor blockers (ARBs) (p=0.01), and statins (p=0.001). Furthermore, compared to those with hs-CRP <3 mg/L, those with hs-CRP ≥3 mg/dL had a significantly higher incidence of dyslipidemia (p=0.001) and hypertension (p=0.001). Conclusion: The results of the current study demonstrated that hs-CRP upon admission is a valid predictor of hospital morbidity and death in patients with AMI who are diabetic or non-diabetic. Individuals with diabetes showed greater CRP levels than non-diabetic AMI patients did.
目的：心血管疾病的不良后果与高敏C反应蛋白（hs-CRP）有关，这是一种残留炎症风险的生物标志物。无论患者是否患有糖尿病，都要评估入院时估计的 hs-CRP 水平与院内后果和死亡之间的关系：这项前瞻性队列研究纳入了 100 名急性心肌梗死（AMI）患者，这些患者既有非 ST 期抬高型心肌梗死（STEMI），也有 STEMI，他们都住进了心脏护理重症监护室的强化治疗病房：与非糖尿病患者相比，糖尿病患者的高血压（P=0.001）和血脂异常（P=0.001）发生率要高得多。糖尿病患者的 hs-CRP 平均水平（6.76±1.12 vs. 3.65±0.98 mg/dL；p=0.01）明显高于非糖尿病患者。同时，与非糖尿病患者相比，糖尿病患者使用阿司匹林（p=0.001）、β-受体阻滞剂（p=0.001）、血管紧张素受体阻滞剂（ARBs）（p=0.01）和他汀类药物（p=0.001）的比例明显更高。此外，与 hs-CRP <3 mg/L 的患者相比，hs-CRP ≥3 mg/dL 的患者血脂异常（p=0.001）和高血压（p=0.001）的发生率明显更高：本研究结果表明，入院时的hs-CRP可有效预测糖尿病或非糖尿病急性心肌梗死患者的住院发病率和死亡率。糖尿病患者的 CRP 水平高于非糖尿病 AMI 患者。
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