Pub Date : 2024-07-12DOI: 10.36347/sjams.2024.v12i07.008
Dr. (Major) Samia Mahmood, Dr. (Major General) Nishat Jubaida, Dr. (Colonel) Md. Monirul Hoque, Dr. Md. Rezaul Islam
Introduction: Hepatitis B virus (HBV) infection remains a significant global health challenge, annually contributing to approximately one million deaths from complications such as liver failure, cirrhosis, and hepatocellular carcinoma (HCC). Methods: This observational, descriptive, cross-sectional study was conducted at the Armed Forces Institute of Pathology (AFIP), Dhaka Cantonment, Dhaka, Bangladesh, from 3rd March 2020 to 2nd September 2020. Inclusion criteria required patients to be HBsAg positive for at least six months, resulting in a total of 101 patients included in this study. HBsAg and HBeAg were detected using ELISA, while HBV DNA levels were quantified by real-time PCR. Result: The study found that 47% of the patients belonged to the 26-45 years age group, with 62% being male and 38% female (male-to-female ratio 1.63:1). Among HBeAg-positive cases, 86.84% had high viral loads (>105 copies/ml), while 13.16% exhibited medium viral loads (103 – 105 copies/ml). Among HBeAg-negative cases, 6.35% showed detectable HBV DNA with low viral loads (<102 copies/ml). Higher sample-to-cut-off ratios (S/CO) indicated elevated HBV DNA levels in HBeAg-positive chronic hepatitis B patients compared to lower ratios in HBeAg-negative patients. Conclusion: Chronic hepatitis B represents a serious viral disease that, without careful monitoring, can lead to the development of HCC and cirrhosis in a significant proportion of patients. Regular surveillance and effective management strategies are essential in mitigating these risks.
{"title":"Investigating the Correlation between Semi quantitative HBeAg and HBV DNA Levels: Validating HBeAg Quantification as a Marker in Asymptomatic HBeAg-Positive Carriers","authors":"Dr. (Major) Samia Mahmood, Dr. (Major General) Nishat Jubaida, Dr. (Colonel) Md. Monirul Hoque, Dr. Md. Rezaul Islam","doi":"10.36347/sjams.2024.v12i07.008","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i07.008","url":null,"abstract":"Introduction: Hepatitis B virus (HBV) infection remains a significant global health challenge, annually contributing to approximately one million deaths from complications such as liver failure, cirrhosis, and hepatocellular carcinoma (HCC). Methods: This observational, descriptive, cross-sectional study was conducted at the Armed Forces Institute of Pathology (AFIP), Dhaka Cantonment, Dhaka, Bangladesh, from 3rd March 2020 to 2nd September 2020. Inclusion criteria required patients to be HBsAg positive for at least six months, resulting in a total of 101 patients included in this study. HBsAg and HBeAg were detected using ELISA, while HBV DNA levels were quantified by real-time PCR. Result: The study found that 47% of the patients belonged to the 26-45 years age group, with 62% being male and 38% female (male-to-female ratio 1.63:1). Among HBeAg-positive cases, 86.84% had high viral loads (>105 copies/ml), while 13.16% exhibited medium viral loads (103 – 105 copies/ml). Among HBeAg-negative cases, 6.35% showed detectable HBV DNA with low viral loads (<102 copies/ml). Higher sample-to-cut-off ratios (S/CO) indicated elevated HBV DNA levels in HBeAg-positive chronic hepatitis B patients compared to lower ratios in HBeAg-negative patients. Conclusion: Chronic hepatitis B represents a serious viral disease that, without careful monitoring, can lead to the development of HCC and cirrhosis in a significant proportion of patients. Regular surveillance and effective management strategies are essential in mitigating these risks.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141654663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.36347/sjams.2024.v12i07.007
Dr. Fatema Ferdous Ara, Dr. Fatema Tuj Johra, Dr. Naoroze Ferdous Romance
Background: Ocular contusions, often resulting from sports-related injuries and falls, present a significant public health concern. This study aims to evaluate the demographic distribution, causes, intraocular pressure (IOP) outcomes, and complications following ocular contusions at the National Institute of Ophthalmology & Hospital in Bangladesh. Methods: This retrospective observational study involved a sample of 50 patients who presented with ocular contusions over a six-month period. Data were collected on patient demographics, the cause of injury, IOP readings, and subsequent complications. The study focused on identifying patterns in age and gender distribution, the prevalence of different causes of contusions, variations in IOP, and the incidence of common ocular complications. Results: The majority of the patients were male (64%), with a notable prevalence of injuries among children aged ≤10 years (44%). Sports-related injuries emerged as the most common cause (48%), followed by falls (26%). A significant proportion of patients (66%) exhibited elevated IOP levels post-injury. The most frequent complications included hyphemia (40%), conjunctival hemorrhage (36%), and corneal abrasion (28%). Notably, glaucoma was a less common but present complication. Conclusion: The study highlights the predominance of sports-related ocular injuries in a young population and the commonality of elevated IOP following such traumas. These findings emphasize the need for targeted preventive strategies and heightened awareness about ocular safety in younger demographics, particularly in the context of sports activities.
{"title":"Evaluating Intraocular Pressure Outcomes Following Ocular Contusion","authors":"Dr. Fatema Ferdous Ara, Dr. Fatema Tuj Johra, Dr. Naoroze Ferdous Romance","doi":"10.36347/sjams.2024.v12i07.007","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i07.007","url":null,"abstract":"Background: Ocular contusions, often resulting from sports-related injuries and falls, present a significant public health concern. This study aims to evaluate the demographic distribution, causes, intraocular pressure (IOP) outcomes, and complications following ocular contusions at the National Institute of Ophthalmology & Hospital in Bangladesh. Methods: This retrospective observational study involved a sample of 50 patients who presented with ocular contusions over a six-month period. Data were collected on patient demographics, the cause of injury, IOP readings, and subsequent complications. The study focused on identifying patterns in age and gender distribution, the prevalence of different causes of contusions, variations in IOP, and the incidence of common ocular complications. Results: The majority of the patients were male (64%), with a notable prevalence of injuries among children aged ≤10 years (44%). Sports-related injuries emerged as the most common cause (48%), followed by falls (26%). A significant proportion of patients (66%) exhibited elevated IOP levels post-injury. The most frequent complications included hyphemia (40%), conjunctival hemorrhage (36%), and corneal abrasion (28%). Notably, glaucoma was a less common but present complication. Conclusion: The study highlights the predominance of sports-related ocular injuries in a young population and the commonality of elevated IOP following such traumas. These findings emphasize the need for targeted preventive strategies and heightened awareness about ocular safety in younger demographics, particularly in the context of sports activities.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.36347/sjams.2024.v12i07.005
Dr. Nazneen Ahmed, Dr. Waliza Rokhsana Hoque, Dr. Ferdousi Begum
Introduction: Intrauterine fetal death (IUFD) is a sad event for both mothers and medical personnel. In the developing world, IUFD is calculated based on deaths at 28 or more weeks of gestation or weight of 1000 gms or more. Traditionally, early nonviable pregnancies (less than 14 weeks) have been terminated by surgical evacuation and later pregnancies (14 weeks onwards) have been ended by medical induction. In this study, we aimed to evaluate the outcome of medical induction for IUFD in a tertiary care hospital. Methods: This was a prospective observational study and was conducted in the Department of Obstetrics & Gynecology, Holy Family Red Crescent Medical College Hospital, Dhaka, Bangladesh during the period from January 2019 to December 2020. In our study, we included 20 pregnant women with IUFD who attended the department of obstetrics & gynecology. Result: The mean age of our patients was 27.25±4.47 years. The majority of patients had 2nd gravida (45%), and most of our patients (45%) were 28-32 weeks pregnant. Among all our diagnosis findings, we found that the majority of patients (50%) had a previous history of IUFD, followed by severe preeclampsia (35%) and pregnancy-induced hypertension (20%). Among all patients, Mifepristone was taken by 100%, followed by Misoprostol was taken by 90%. The majority (40%) of patients were successful in IUFD after the combination of Mifepristone and 2nd dose of Misoprostol. Conclusion: Our study findings showed that the combination of mifepristone with misoprostol was more effective than misoprostol or mifepristone alone for the induction of labor in IUFD, in terms of a higher rate of successful delivery.
{"title":"“Medical Induction for Intrauterine Fetal Death (IUFD) in a Tertiary Care Hospital”","authors":"Dr. Nazneen Ahmed, Dr. Waliza Rokhsana Hoque, Dr. Ferdousi Begum","doi":"10.36347/sjams.2024.v12i07.005","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i07.005","url":null,"abstract":"Introduction: Intrauterine fetal death (IUFD) is a sad event for both mothers and medical personnel. In the developing world, IUFD is calculated based on deaths at 28 or more weeks of gestation or weight of 1000 gms or more. Traditionally, early nonviable pregnancies (less than 14 weeks) have been terminated by surgical evacuation and later pregnancies (14 weeks onwards) have been ended by medical induction. In this study, we aimed to evaluate the outcome of medical induction for IUFD in a tertiary care hospital. Methods: This was a prospective observational study and was conducted in the Department of Obstetrics & Gynecology, Holy Family Red Crescent Medical College Hospital, Dhaka, Bangladesh during the period from January 2019 to December 2020. In our study, we included 20 pregnant women with IUFD who attended the department of obstetrics & gynecology. Result: The mean age of our patients was 27.25±4.47 years. The majority of patients had 2nd gravida (45%), and most of our patients (45%) were 28-32 weeks pregnant. Among all our diagnosis findings, we found that the majority of patients (50%) had a previous history of IUFD, followed by severe preeclampsia (35%) and pregnancy-induced hypertension (20%). Among all patients, Mifepristone was taken by 100%, followed by Misoprostol was taken by 90%. The majority (40%) of patients were successful in IUFD after the combination of Mifepristone and 2nd dose of Misoprostol. Conclusion: Our study findings showed that the combination of mifepristone with misoprostol was more effective than misoprostol or mifepristone alone for the induction of labor in IUFD, in terms of a higher rate of successful delivery.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The procedure of percutaneous nephrolithotomy (PCNL) is considered a minimally invasive method for removing stones from the kidneys or upper ureters. PCNL can cause a wide range of complications, such as urosepsis, a rare but serious complication. Methods: A retrospective cohort study of patients who underwent PCNL from the period June 2022 to July 2023 was conducted at Department of Urology, National Institute of Kidney diseases and Urology, Shere-e-Banglanagar, Dhaka, Bangladesh. Data were collected by chart review using the Best CARE system. SPSS version 23 (IBM Corporation, Armonk, NY, USA) was used. Qualitative variables were expressed as percentages and frequencies. The chi-square test was used to compare the qualitative variables. The K-S test was used to check the normality of the data. Quantitative variables were compared between groups using the independent sample t-test and the nonparametric Mann-Whitney test. Fisher's exact test was used to compare categorical variables. Results: A total of 100 patients were included in this study. The mean age of the participants overall was found to be 49. About 70 (70%) of the participants were male. Regarding risk factors for urosepsis, diabetes mellitus was found in 35 (38%) of the participants. The incidence of urosepsis following PCNL was found to be 3 (1.9%) of the patients. The most frequently reported indication was found to be unilateral renal stones. The most frequently reported type of stone in the analysis was found to be calcium oxalate in nearly two-thirds 63 (63%) of the patients. Conclusion: The incidence of urosepsis among the patients who underwent PCNL was less than 2%. Diabetes mellitus, followed by hypertension, were the most prevalent co-morbidities among the participants. Inj Meropenam was the antibiotic of choice when treating patients and following urosepsis.
{"title":"Prediction of Urosepsis Following PCNL: A Retrospective Cohort Study","authors":"Zulker Naimul Islam, Monirul Islam, Probir Kumar Roy, Nitai Pada Biswas","doi":"10.36347/sjams.2024.v12i07.006","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i07.006","url":null,"abstract":"Introduction: The procedure of percutaneous nephrolithotomy (PCNL) is considered a minimally invasive method for removing stones from the kidneys or upper ureters. PCNL can cause a wide range of complications, such as urosepsis, a rare but serious complication. Methods: A retrospective cohort study of patients who underwent PCNL from the period June 2022 to July 2023 was conducted at Department of Urology, National Institute of Kidney diseases and Urology, Shere-e-Banglanagar, Dhaka, Bangladesh. Data were collected by chart review using the Best CARE system. SPSS version 23 (IBM Corporation, Armonk, NY, USA) was used. Qualitative variables were expressed as percentages and frequencies. The chi-square test was used to compare the qualitative variables. The K-S test was used to check the normality of the data. Quantitative variables were compared between groups using the independent sample t-test and the nonparametric Mann-Whitney test. Fisher's exact test was used to compare categorical variables. Results: A total of 100 patients were included in this study. The mean age of the participants overall was found to be 49. About 70 (70%) of the participants were male. Regarding risk factors for urosepsis, diabetes mellitus was found in 35 (38%) of the participants. The incidence of urosepsis following PCNL was found to be 3 (1.9%) of the patients. The most frequently reported indication was found to be unilateral renal stones. The most frequently reported type of stone in the analysis was found to be calcium oxalate in nearly two-thirds 63 (63%) of the patients. Conclusion: The incidence of urosepsis among the patients who underwent PCNL was less than 2%. Diabetes mellitus, followed by hypertension, were the most prevalent co-morbidities among the participants. Inj Meropenam was the antibiotic of choice when treating patients and following urosepsis.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.36347/sjams.2024.v12i07.004
Dr. Md. Shahidul Islam Khan, Dr. Md. Burhan Uddin Khan, Dr. Khadija Rahman, Dr. Shariful Islam Seraji, Dr. Md. Ashiqur Rahman
Introduction: Laparoscopic cholecystectomy is a minimally invasive surgical procedure for removal of a diseased gallbladder which has different post-operative pain management systems. Objective: The objective of this study was to compare pain management in the port sites local anaesthetics and standard analgesics after laparoscopic cholecystectomy (LC). Methodology: A comparative study was conducted on 270 patients with LC under elective conditions for symptomatic cholelithiasis, with a mean age of 49±3.51, treated between 2021 and 2023 in the Department of Surgery at Holy Family Red Crescent Medical College Hospital, Dhaka, Bangladesh. Patients were divided into the Local Anaesthetics Group (134 patients who received Local Anaesthetics through the port site) and the Standard Analgesia Group (136 patients who received postoperative analgesia with NSAIDs or tramadol). Pain was measured by the Visual Analog Scale (VAS) in all patients at the 1st, 6th, 12th, and 24th postoperatively. Results: Both groups had similar demographic characteristics, surgery duration, and hospitalization. In the local anaesthetics group, the average pain scores at 1st, 6th, 12th, and 24th hours were 3.6, 4.4, 2.1, and 1.9, respectively. For the Standard Analgesia Group, the scores were 7.6, 6.9, 2.3, and 2.1. There was a significant reduction in pain intensity (p<0.001) in the local anaesthetics group at the 1st and 6th hours compared to the Standard Analgesia Group. However, there was no difference in pain intensity at the 12th and 24th hours. Additionally, the use of pain medication decreased significantly in the local anaesthetics group. Conclusion: This study demonstrated that local anesthetic application to the port sites after LC provides a significant decrease in pain intensity in the first 6h postoperatively. The study also found that fewer analgesic drugs will be used for POP in these patients.
{"title":"Port Site Local Anaesthetics Application Versus Standard Analgesics for Postoperative Pain Control in Laparoscopic Cholecystectomy","authors":"Dr. Md. Shahidul Islam Khan, Dr. Md. Burhan Uddin Khan, Dr. Khadija Rahman, Dr. Shariful Islam Seraji, Dr. Md. Ashiqur Rahman","doi":"10.36347/sjams.2024.v12i07.004","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i07.004","url":null,"abstract":"Introduction: Laparoscopic cholecystectomy is a minimally invasive surgical procedure for removal of a diseased gallbladder which has different post-operative pain management systems. Objective: The objective of this study was to compare pain management in the port sites local anaesthetics and standard analgesics after laparoscopic cholecystectomy (LC). Methodology: A comparative study was conducted on 270 patients with LC under elective conditions for symptomatic cholelithiasis, with a mean age of 49±3.51, treated between 2021 and 2023 in the Department of Surgery at Holy Family Red Crescent Medical College Hospital, Dhaka, Bangladesh. Patients were divided into the Local Anaesthetics Group (134 patients who received Local Anaesthetics through the port site) and the Standard Analgesia Group (136 patients who received postoperative analgesia with NSAIDs or tramadol). Pain was measured by the Visual Analog Scale (VAS) in all patients at the 1st, 6th, 12th, and 24th postoperatively. Results: Both groups had similar demographic characteristics, surgery duration, and hospitalization. In the local anaesthetics group, the average pain scores at 1st, 6th, 12th, and 24th hours were 3.6, 4.4, 2.1, and 1.9, respectively. For the Standard Analgesia Group, the scores were 7.6, 6.9, 2.3, and 2.1. There was a significant reduction in pain intensity (p<0.001) in the local anaesthetics group at the 1st and 6th hours compared to the Standard Analgesia Group. However, there was no difference in pain intensity at the 12th and 24th hours. Additionally, the use of pain medication decreased significantly in the local anaesthetics group. Conclusion: This study demonstrated that local anesthetic application to the port sites after LC provides a significant decrease in pain intensity in the first 6h postoperatively. The study also found that fewer analgesic drugs will be used for POP in these patients.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-02DOI: 10.36347/sjams.2024.v12i07.001
Dr. Mst. Mostana Nazma Begum, Dr. Md. Nazibullah, Dr. Suraiya Pervin, Dr. Tasnuva Andalib Mahbub, Dr. Shamima Nasreen
Background: Laboratory tests such as the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have been utilized as indicators of inflammation and disease activity in rheumatoid arthritis (RA), but there is still no clear consensus on when to employ one, the other, or both. Aim of the Study: The study aims to analyze the association between ESR and CRP levels in active RA patients and disease activity indicators. Methods: This study was conducted at the Orthopaedics OPD at TMSS medical college hospital & Ibne Sina Diagnostic Centre Bogura, Bangladesh, from January 2023 to December 2023. In the study, 120 patients with active RA were involved. All of the data was gathered, recorded into a Microsoft Excel work sheet, and then descriptive statistics were used in SPSS 23.0 for analysis. Results: the study included 120 RA patients, with 88 females and 32 males. The participants' ages ranged from 25 to 69 years (Mean±SD = 47.7±11.3). During the trial, all patients had disease activity, with DAS28 scores ranging from 2.9 to 7.5 (Mean ± SD = 5.42 ± 1.1). ESR readings ranged from 10 to 150mm/h in the first hour (Mean±SD = 52.9±33.9). CRP was positive in 81 patients but negative in 39 (67.5% vs. 32.5%). CRP levels ranged from 0.6 to 65 mg/dL (Mean±SD = 18.1±15.8). Male and female patients revealed significant differences in DAS28 (P=0.031). The study found a significant correlation between DAS28 values, tender and swollen joints, and ESR values (P values < 0.001, < 0.001, 0.004, respectively). However, there was no significant correlation between DAS28 patients' age and CRP values (P values 0.60, 0.18, respectively). Conclusion: Our study reveals that CRP is not a reliable indicator of inflammatory activity in RA patients in clinical settings. The use of CRP as a marker of inflammation in everyday practice should be reconsidered. ESR values were positively correlated and significant with DAS28 values.
{"title":"Comparative Usefulness of C-reactive Protein and Erythrocyte Sedimentation Rate in Patients with Rheumatoid Arthritis","authors":"Dr. Mst. Mostana Nazma Begum, Dr. Md. Nazibullah, Dr. Suraiya Pervin, Dr. Tasnuva Andalib Mahbub, Dr. Shamima Nasreen","doi":"10.36347/sjams.2024.v12i07.001","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i07.001","url":null,"abstract":"Background: Laboratory tests such as the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have been utilized as indicators of inflammation and disease activity in rheumatoid arthritis (RA), but there is still no clear consensus on when to employ one, the other, or both. Aim of the Study: The study aims to analyze the association between ESR and CRP levels in active RA patients and disease activity indicators. Methods: This study was conducted at the Orthopaedics OPD at TMSS medical college hospital & Ibne Sina Diagnostic Centre Bogura, Bangladesh, from January 2023 to December 2023. In the study, 120 patients with active RA were involved. All of the data was gathered, recorded into a Microsoft Excel work sheet, and then descriptive statistics were used in SPSS 23.0 for analysis. Results: the study included 120 RA patients, with 88 females and 32 males. The participants' ages ranged from 25 to 69 years (Mean±SD = 47.7±11.3). During the trial, all patients had disease activity, with DAS28 scores ranging from 2.9 to 7.5 (Mean ± SD = 5.42 ± 1.1). ESR readings ranged from 10 to 150mm/h in the first hour (Mean±SD = 52.9±33.9). CRP was positive in 81 patients but negative in 39 (67.5% vs. 32.5%). CRP levels ranged from 0.6 to 65 mg/dL (Mean±SD = 18.1±15.8). Male and female patients revealed significant differences in DAS28 (P=0.031). The study found a significant correlation between DAS28 values, tender and swollen joints, and ESR values (P values < 0.001, < 0.001, 0.004, respectively). However, there was no significant correlation between DAS28 patients' age and CRP values (P values 0.60, 0.18, respectively). Conclusion: Our study reveals that CRP is not a reliable indicator of inflammatory activity in RA patients in clinical settings. The use of CRP as a marker of inflammation in everyday practice should be reconsidered. ESR values were positively correlated and significant with DAS28 values.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141687946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-02DOI: 10.36347/sjams.2024.v12i07.002
Dr. Shah Md. Nahid Aktarul Islam, Prof. Syed Nasir Uddin, Prof. Mohsin Ahmed, Dr. Sayeedur Rahman Khan, Dr. Md. Shariful Islam, Dr. Akter Zahan
Background: Cardiovascular diseases (CVDs) are a major public health issue around the world. The TyG index has been identified as a credible alternative marker of insulin resistance (IR), which may explain its relationship to CVD. Aim of the Study: The aim of our study was to assess the angiographic severity of coronary artery disease in patients by the SYNTAX score. Methods: This cross-sectional observational study was conducted in the department of Cardiology, National Institute of Cardiovascular Diseases and Hospital (NICVD), Dhaka, Bangladesh, from September 2021 to August 2022. The study included 200 patients. All acquired data was entered into a Microsoft Excel Work Sheet and analyzed using descriptive statistics in SPSS 24.0. Results: The mean age (in years) for Group 1 was 60.20±4.65 (SD) years, and that for Group 2 was 63.03±6.16 (SD) years. Patients with a high TyG index (OR - 5.27, 95% CI (1.71-16.19)) had a significantly 5.27 times higher chance of having intermediate to high SYNTAX scores than patients with a low TyG index. Male patients had 1.39 times more chances of having intermediate to high SYNTAX scores (≥23) than female patients. High TyG index had significantly 4.81 times higher chances of having intermediate to high SYNTAX score (≥23) than the patients with low TyG index. TyG index and SYNTAX score was significantly positively correlated (r=+0.626, p<0.001) for NSTEMI Patients. Conclusion: This study found that the high TyG index had a significant positive association with intermediate to high SYNTAX scores, which indicates disease severity.
{"title":"Glucose Triglyceride Index as A Predictor of Coronary Artery Severity Assessed with Syntax Score in Acute Coronary Syndrome Patients","authors":"Dr. Shah Md. Nahid Aktarul Islam, Prof. Syed Nasir Uddin, Prof. Mohsin Ahmed, Dr. Sayeedur Rahman Khan, Dr. Md. Shariful Islam, Dr. Akter Zahan","doi":"10.36347/sjams.2024.v12i07.002","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i07.002","url":null,"abstract":"Background: Cardiovascular diseases (CVDs) are a major public health issue around the world. The TyG index has been identified as a credible alternative marker of insulin resistance (IR), which may explain its relationship to CVD. Aim of the Study: The aim of our study was to assess the angiographic severity of coronary artery disease in patients by the SYNTAX score. Methods: This cross-sectional observational study was conducted in the department of Cardiology, National Institute of Cardiovascular Diseases and Hospital (NICVD), Dhaka, Bangladesh, from September 2021 to August 2022. The study included 200 patients. All acquired data was entered into a Microsoft Excel Work Sheet and analyzed using descriptive statistics in SPSS 24.0. Results: The mean age (in years) for Group 1 was 60.20±4.65 (SD) years, and that for Group 2 was 63.03±6.16 (SD) years. Patients with a high TyG index (OR - 5.27, 95% CI (1.71-16.19)) had a significantly 5.27 times higher chance of having intermediate to high SYNTAX scores than patients with a low TyG index. Male patients had 1.39 times more chances of having intermediate to high SYNTAX scores (≥23) than female patients. High TyG index had significantly 4.81 times higher chances of having intermediate to high SYNTAX score (≥23) than the patients with low TyG index. TyG index and SYNTAX score was significantly positively correlated (r=+0.626, p<0.001) for NSTEMI Patients. Conclusion: This study found that the high TyG index had a significant positive association with intermediate to high SYNTAX scores, which indicates disease severity.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-02DOI: 10.36347/sjams.2024.v12i07.003
Rashmi Manjushree Adhikari, Bandana Padhee
Introduction: Stature, an individual inherent characteristic, is an important measurement of physical identity. Percutaneous measurement of length of ulna, amongst sundry methods, can be quantitatively used to express height, and has been carried out in Nepalese population in this study. Method: A cross-sectional, descriptive study was conducted in 198 randomly selected healthy peoples, aged 19-25 years, attending outpatient department at Lumbini Medical College, Palpa, Nepal. Length of bilateral ulna, from tip of olecranon to the tip of styloid process, in flexed elbow, and height of each induvial participant were measured in standard position (Frankfurt plane). Means and standard deviations of all variables were recorded and tabulated; and regression equations were calculated for estimating height across each diverse subsets of participants. Results: A significant correlation was found between ulnar length and stature (right ulna male: 22.98±1.29cm; right ulna female: 23.21±1.92cm; left ulna male: 22.85±1.30; left ulna female: 23.10±1.95; mean height in males: 153.98±1.29; mean height in females: 151.67±1.92). Conclusion: Being a percutaneous and easy to measure bone, ulnar length can be an infallible technique for estimating an individual’s height, thus becoming nifty for anatomists, anthropologists, and forensic experts.
{"title":"Length of Ulna and Its Correlation with Stature in Nepalese Population","authors":"Rashmi Manjushree Adhikari, Bandana Padhee","doi":"10.36347/sjams.2024.v12i07.003","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i07.003","url":null,"abstract":"Introduction: Stature, an individual inherent characteristic, is an important measurement of physical identity. Percutaneous measurement of length of ulna, amongst sundry methods, can be quantitatively used to express height, and has been carried out in Nepalese population in this study. Method: A cross-sectional, descriptive study was conducted in 198 randomly selected healthy peoples, aged 19-25 years, attending outpatient department at Lumbini Medical College, Palpa, Nepal. Length of bilateral ulna, from tip of olecranon to the tip of styloid process, in flexed elbow, and height of each induvial participant were measured in standard position (Frankfurt plane). Means and standard deviations of all variables were recorded and tabulated; and regression equations were calculated for estimating height across each diverse subsets of participants. Results: A significant correlation was found between ulnar length and stature (right ulna male: 22.98±1.29cm; right ulna female: 23.21±1.92cm; left ulna male: 22.85±1.30; left ulna female: 23.10±1.95; mean height in males: 153.98±1.29; mean height in females: 151.67±1.92). Conclusion: Being a percutaneous and easy to measure bone, ulnar length can be an infallible technique for estimating an individual’s height, thus becoming nifty for anatomists, anthropologists, and forensic experts.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141686315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.36347/sjams.2024.v12i06.002
Dr. Rawshan Ara Sultana, Dr. Labiba Yasmin Rahman, Dr. Marufa Khatun, Dr. Md. Faysal Kamal, Dr. Abu Taher Mohammad Nurul Amin, Dr Tamanna Rahman
Background: High-risk HPV strains are a well-known contributor to the carcinogenesis of cervical squamous cell carcinoma (SCC). Indeed, there has been a high detection of HPV DNA in SCC and precancerous lesions. Objective: The aim of the study was to assess the Relationship Between Human Papillomavirus Infection and P16INK4a Overexpression in Cervical Squamous Cell Carcinoma. Methodology: This descriptive cross-sectional study was carried out in the Pathology Department of DMC with collaboration of Bangabandhu Sreikh Mujib Medical University (BSMMU), Microbiology Department and Bangladesh Agricultural University (BAU), Mymansingh, during July 2017 to June 2018. A total 50 VIA positive and clinically suspected premalignant and malignant patient’s attendant at DMC included as study population. Colposcopic biopsy specimens were sent to the Department of Pathology, DMCH, for histopathological examination. Some portion of biopsy samples were preserved at -4ºC for HR-HPV DNA detection. Statistical analyses were done by using the SPSS 26.0. Result: Highest number of cases 20 (40%) were in fourth decade and their mean age was found to be 44.20±11.20, ranging from 28 to 67 years. Among 50 positive cases, maximum number of 32 (62%) cases were married between 16 to 20 years of age, 12 (22%) cases were married in less than 15 years of age and 6 (8%) cases were married at more than 20 years of age. The findings of colposcopic examinations of total 50 cases. Common diagnoses were CIN II in 24 (48%) cases, 8(16%) case represented CIN III, Squamous cell carcinoma in 16 (32%) cases and Adeno Carcinoma 2(4%) cases. In comparison of p16 score with cervical lesions in study subjects there were 26 true positive cases and 13 true negative cases. According to p16 score a total 37 (26 true positive+ 11 false positive) cases were p16 positive. Out of which 16(32.0%) and 21(42.0%) were HR-HPV positive and negative respectively. Similarly according to p16 score 13 nevative cases ........
{"title":"Relationship between P16INK4a Overexpression in Human Papillomavirus Infection in High Grade CIN and Cervical Carcinoma","authors":"Dr. Rawshan Ara Sultana, Dr. Labiba Yasmin Rahman, Dr. Marufa Khatun, Dr. Md. Faysal Kamal, Dr. Abu Taher Mohammad Nurul Amin, Dr Tamanna Rahman","doi":"10.36347/sjams.2024.v12i06.002","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i06.002","url":null,"abstract":"Background: High-risk HPV strains are a well-known contributor to the carcinogenesis of cervical squamous cell carcinoma (SCC). Indeed, there has been a high detection of HPV DNA in SCC and precancerous lesions. Objective: The aim of the study was to assess the Relationship Between Human Papillomavirus Infection and P16INK4a Overexpression in Cervical Squamous Cell Carcinoma. Methodology: This descriptive cross-sectional study was carried out in the Pathology Department of DMC with collaboration of Bangabandhu Sreikh Mujib Medical University (BSMMU), Microbiology Department and Bangladesh Agricultural University (BAU), Mymansingh, during July 2017 to June 2018. A total 50 VIA positive and clinically suspected premalignant and malignant patient’s attendant at DMC included as study population. Colposcopic biopsy specimens were sent to the Department of Pathology, DMCH, for histopathological examination. Some portion of biopsy samples were preserved at -4ºC for HR-HPV DNA detection. Statistical analyses were done by using the SPSS 26.0. Result: Highest number of cases 20 (40%) were in fourth decade and their mean age was found to be 44.20±11.20, ranging from 28 to 67 years. Among 50 positive cases, maximum number of 32 (62%) cases were married between 16 to 20 years of age, 12 (22%) cases were married in less than 15 years of age and 6 (8%) cases were married at more than 20 years of age. The findings of colposcopic examinations of total 50 cases. Common diagnoses were CIN II in 24 (48%) cases, 8(16%) case represented CIN III, Squamous cell carcinoma in 16 (32%) cases and Adeno Carcinoma 2(4%) cases. In comparison of p16 score with cervical lesions in study subjects there were 26 true positive cases and 13 true negative cases. According to p16 score a total 37 (26 true positive+ 11 false positive) cases were p16 positive. Out of which 16(32.0%) and 21(42.0%) were HR-HPV positive and negative respectively. Similarly according to p16 score 13 nevative cases ........","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.36347/sjams.2024.v12i06.001
Dr. SM Hedayetul Islam Sagar, Dr. Nashid Amir, Dr. Md. Husnaion Zubery
Background: In extrahepatic biliary carcinoma patients, unresectable disease is frequently discovered during exploration despite thorough preoperative assessment, leading to unnecessary laparotomy. Gallbladder carcinoma ranks fifth among gastrointestinal malignancies, following colorectal, pancreatic, gastric, and esophageal carcinomas. Aim of the study: The aim of the study was to establish the diagnostic usefulness of computed tomography (CT) in the diagnosis of gallbladder mass. Methods: This case-control study was conducted at the Department of Radiology and Imaging, Rajshahi Medical College Hospital, Rajshahi, Bangladesh from March 2018 to August 2018. The study included 65 patients diagnosed with a gallbladder mass, selected through purposive sampling. SPSS version 23.0 was utilized for data analysis. Results: CT scans accurately predicted various features of gallbladder mass, showing high sensitivity, specificity, and accuracy, with positive and negative predictive values of ≥95% for adenocarcinoma, squamous carcinoma, cholecystitis, metastases, GB polyp, and adenoma. Chronic cholecystitis sensitivity was over 83%. Overall, CT diagnosis performed at least 88.9% across all features. The histopathological assessment also detected nearly similar features of gallbladder mass. Conclusion: Computed tomography (CT) serves as a valuable diagnostic tool for distinguishing gallbladder neoplasms preoperatively. It is worth noting that CT scans aid in the rational management approach for patients with gallbladder neoplasms.
{"title":"Computed Tomography Evaluation of Gall Bladder Mass with Histopathological Correlation","authors":"Dr. SM Hedayetul Islam Sagar, Dr. Nashid Amir, Dr. Md. Husnaion Zubery","doi":"10.36347/sjams.2024.v12i06.001","DOIUrl":"https://doi.org/10.36347/sjams.2024.v12i06.001","url":null,"abstract":"Background: In extrahepatic biliary carcinoma patients, unresectable disease is frequently discovered during exploration despite thorough preoperative assessment, leading to unnecessary laparotomy. Gallbladder carcinoma ranks fifth among gastrointestinal malignancies, following colorectal, pancreatic, gastric, and esophageal carcinomas. Aim of the study: The aim of the study was to establish the diagnostic usefulness of computed tomography (CT) in the diagnosis of gallbladder mass. Methods: This case-control study was conducted at the Department of Radiology and Imaging, Rajshahi Medical College Hospital, Rajshahi, Bangladesh from March 2018 to August 2018. The study included 65 patients diagnosed with a gallbladder mass, selected through purposive sampling. SPSS version 23.0 was utilized for data analysis. Results: CT scans accurately predicted various features of gallbladder mass, showing high sensitivity, specificity, and accuracy, with positive and negative predictive values of ≥95% for adenocarcinoma, squamous carcinoma, cholecystitis, metastases, GB polyp, and adenoma. Chronic cholecystitis sensitivity was over 83%. Overall, CT diagnosis performed at least 88.9% across all features. The histopathological assessment also detected nearly similar features of gallbladder mass. Conclusion: Computed tomography (CT) serves as a valuable diagnostic tool for distinguishing gallbladder neoplasms preoperatively. It is worth noting that CT scans aid in the rational management approach for patients with gallbladder neoplasms.","PeriodicalId":504829,"journal":{"name":"Scholars Journal of Applied Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141281930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：