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FROM AUTOLOGOUS CELL BANKING TO ALLOGENEIC CELL THERAPY MANUFACTURING: DEVELOPING A CMC STRATEGY FOR THE PRODUCTION OF A GMP-COMPLIANT MSC-BASED THERAPY 从自体细胞库到异体细胞疗法生产：为生产符合 GMP 标准的基于 MSC 的疗法制定 CMC 战略
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.246
F.C. Bombaldi de Souza, E.D. Mariano, D. N. da Rocha, K. Menezes, T.C. Lopes de Castro, R. V. Capelletti, Y. M. Berto, F. G. Duarte, W. Jeveaux, R.D. Fanganiello, J. M. Ferreira
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引用次数: 0
ENHANCING EV-AAV INCORPORATION: INSIGHTS INTO NATURAL LOADING AND LOADING STRATEGIES FOR IMPROVED GENE THERAPY VECTOR DELIVERY 增强 ev-aav 的结合：深入了解改进基因治疗载体递送的自然装载和装载策略
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.168
I. Vorobieva, H. Friedrichson, N. Ahlskog, C. Staton, M. Wood, M. Conceicao
{"title":"ENHANCING EV-AAV INCORPORATION: INSIGHTS INTO NATURAL LOADING AND LOADING STRATEGIES FOR IMPROVED GENE THERAPY VECTOR DELIVERY","authors":"I. Vorobieva, H. Friedrichson, N. Ahlskog, C. Staton, M. Wood, M. Conceicao","doi":"10.1016/j.jcyt.2024.03.168","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.168","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":"11 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DIFFERENCES IN ACTIVITY OF TCR-T CELLS TARGETING MINOR HISTOCOMPATIBILITY ANTIGENS FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES 靶向次要组织相容性抗原的 TCR-T 细胞在治疗血液恶性肿瘤方面的活性差异
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.348
N. Keshavarzian, A. Minguy, N. Masroori, J. Bastien, J. Trottier, J. Dardon, V. Dave, D. Roy
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引用次数: 0
ACTIVATION, EXPANSION, AND CULTURE OF HUMAN T CELLS INCORPORATING IMMUNOCULTTM CGMP-COMPLIANT ANCILLARY REAGENTS 活化、扩增和培养人类 t 细胞，并结合符合免疫细胞培养规范的 cgmp 辅助试剂
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.389
C. Siatskas, J. Yu, A. Wang, R. Penner, D. Nooyen, F. Antignano, A.I. Kokaji, S.A. Louis, A. Eaves, N. Tabatabaei-Zavareh
{"title":"ACTIVATION, EXPANSION, AND CULTURE OF HUMAN T CELLS INCORPORATING IMMUNOCULTTM CGMP-COMPLIANT ANCILLARY REAGENTS","authors":"C. Siatskas, J. Yu, A. Wang, R. Penner, D. Nooyen, F. Antignano, A.I. Kokaji, S.A. Louis, A. Eaves, N. Tabatabaei-Zavareh","doi":"10.1016/j.jcyt.2024.03.389","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.389","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATION OF REGULATORY PARTICULARS AND CMC REVIEW ISSUES FOR FDA-APPROVED CELL THERAPY PRODUCTS 评估 FDA 批准的细胞治疗产品的监管细节和 cmc 审查问题
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.224
A. McCord
{"title":"EVALUATION OF REGULATORY PARTICULARS AND CMC REVIEW ISSUES FOR FDA-APPROVED CELL THERAPY PRODUCTS","authors":"A. McCord","doi":"10.1016/j.jcyt.2024.03.224","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.224","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPROVING PRODUCTIVITY AND REDUCING COGS USING DIELECTRIC SPECTROSCOPY AS A PAT TOOL TO MEASURE LIVE BIOMASS IN REGENERATIVE MEDICINE, CELL & GENE THERAPY, VACCINE/VIRAL VECTOR AND OTHER CELL CULTURE APPLICATIONS 在再生医学、细胞和基因治疗、疫苗/病毒载体及其他细胞培养应用中，使用介电光谱作为测量活体生物量的拍片工具，提高生产率，降低成本
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.276
A. Bhat, J. Poppleton
{"title":"IMPROVING PRODUCTIVITY AND REDUCING COGS USING DIELECTRIC SPECTROSCOPY AS A PAT TOOL TO MEASURE LIVE BIOMASS IN REGENERATIVE MEDICINE, CELL & GENE THERAPY, VACCINE/VIRAL VECTOR AND OTHER CELL CULTURE APPLICATIONS","authors":"A. Bhat, J. Poppleton","doi":"10.1016/j.jcyt.2024.03.276","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.276","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":"101 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PROCESS DEVELOPMENT FOR SCALABLE ALLOGENEIC CAR-T MANUFACTURING IN STIRRED-TANK BIOREACTORS: PERFUSION OPTIMISATION, MULTI-LITRE SCALE-UP AND AUTOMATED HARVESTING 搅拌罐生物反应器中可扩展的异体 CAR-T 生产工艺开发：灌注优化、多升放大和自动收获
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.392
P. Springuel, T. Hood, F. Slingsby, N. Bevan, A. Frangleton, M. Szelwicki, T. Schmidberger, W. Geis, J. Hengst, N. Dianat, Q. Rafiq
{"title":"PROCESS DEVELOPMENT FOR SCALABLE ALLOGENEIC CAR-T MANUFACTURING IN STIRRED-TANK BIOREACTORS: PERFUSION OPTIMISATION, MULTI-LITRE SCALE-UP AND AUTOMATED HARVESTING","authors":"P. Springuel, T. Hood, F. Slingsby, N. Bevan, A. Frangleton, M. Szelwicki, T. Schmidberger, W. Geis, J. Hengst, N. Dianat, Q. Rafiq","doi":"10.1016/j.jcyt.2024.03.392","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.392","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":"87 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE EFFECT OF DIFFERENT ISOLATION METHODS ON THE IMMUNOMODULATORY POTENCY OF EXTRACELLULAR VESICLES ISOLATED FROM AN IMMORTALISED MESENCHYMAL STROMAL CELL LINE 不同分离方法对从永生间充质基质细胞系分离出的细胞外囊泡的免疫调节效力的影响
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.161
K. Richmond, M. Moore, Y. Zhao, L. Smyth, S. Ayoub, A. Nowocin
{"title":"THE EFFECT OF DIFFERENT ISOLATION METHODS ON THE IMMUNOMODULATORY POTENCY OF EXTRACELLULAR VESICLES ISOLATED FROM AN IMMORTALISED MESENCHYMAL STROMAL CELL LINE","authors":"K. Richmond, M. Moore, Y. Zhao, L. Smyth, S. Ayoub, A. Nowocin","doi":"10.1016/j.jcyt.2024.03.161","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.161","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":"31 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RECOMBINANT, FULL-LENGTH LAMININS SUPPORTING CELLS IN ALL CULTURE FORMATS 重组全长层粘连蛋白支持所有培养格式的细胞
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.460
E.L. Graham, K. Payte, H. Berthag, T. Mader, N. Fereydouni, M. Kele
{"title":"RECOMBINANT, FULL-LENGTH LAMININS SUPPORTING CELLS IN ALL CULTURE FORMATS","authors":"E.L. Graham, K. Payte, H. Berthag, T. Mader, N. Fereydouni, M. Kele","doi":"10.1016/j.jcyt.2024.03.460","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.460","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ARTIFICIAL ANTIGEN PRESENTING CELLS FOR CRYOPRESERVED REGULATORY T-CELLS ACTIVATION AND EXPANSION 用于激活和扩增冷冻调节性 T 细胞的人工抗原递呈细胞
Cytotherapy
Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.315
J. Chung, F. Zhorabek, C. Lau, Y. Chau
{"title":"ARTIFICIAL ANTIGEN PRESENTING CELLS FOR CRYOPRESERVED REGULATORY T-CELLS ACTIVATION AND EXPANSION","authors":"J. Chung, F. Zhorabek, C. Lau, Y. Chau","doi":"10.1016/j.jcyt.2024.03.315","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.315","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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