Sign language recognition (SLR) from videos constitutes a captivating problem in gesture recognition, requiring the interpretation of hand movements, facial expressions, and body postures. The complexity of sign formation, signing variability among signers, and the technical hurdles of visual detection and tracking render SLR a challenging task. At the same time, the scarcity of large-scale SLR datasets, which are critical for developing robust data-intensive deep-learning SLR models, exacerbates these issues. In this article, we introduce a multi-signer video corpus of Greek Sign Language (GSL), which is the largest GSL database to date, serving as a valuable resource for SLR research. This corpus comprises an extensive RGB+D video collection that conveys rich lexical content in a multi-modal fashion, encompassing three subsets: (i) isolated signs; (ii) continuous signing; and (iii) continuous alphabet fingerspelling of words. Moreover, we introduce a comprehensive experimental setup that paves the way for more accurate and robust SLR solutions. In particular, except for the multi-signer (MS) and signer-independent (SI) settings, we employ a signer-adapted (SA) experimental paradigm, facilitating a comprehensive evaluation of system performance across various scenarios. Further, we provide three baseline SLR systems for isolated signs, continuous signing, and continuous fingerspelling. These systems leverage cutting-edge methods in deep learning and sequence modeling to capture the intricate temporal dynamics inherent in sign gestures. The models are evaluated on the three corpus subsets, setting their state-of-the-art recognition benchmark. The SL-ReDu GSL corpus, including its recommended experimental frameworks, is publicly available at https://sl-redu.e-ce.uth.gr/corpus.