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Beyond the ink: Marking the skin with henna through ultrasound gel 墨水之外:通过超声波凝胶用指甲花在皮肤上做标记。
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-11 DOI: 10.1016/j.clinimag.2025.110410
Samuel Jang , Brooke E. Willborg , Gina K. Hesley , Nathan J. Brinkman , Nho V. Tran , Matthew W. Urban , Christine U. Lee

Purpose

To evaluate henna as a durable skin marker on various skin tones for sonographic targeting and to identify the shortest duration of henna application needed for practical clinical workflow.

Materials and methods

Prospective study applying seven henna lines through ultrasound (US) gel on the forearms of 15 healthy participants equally represented across the validated six-color bar tool. Color bar categories 1–2, 3–4, and 5–6 were designated low, moderate, and high-melanin groups, respectively. Each subsequent line was applied with staining wait-times ranging from 10 to 480 s. Serial photographs were obtained after scrubbing with chlorhexidine every 2–3 days with the number of clearly visible lines assessed by participants, by individual and consensus physician reads, and by band intensity quantification.

Results

Henna could be applied through US gel and the markings were resistant to chlorhexidine scrubbing. Staining wait-times for 60, 120, and 240 s resulted in visible lines for 6, 8, and 10 days (low-melanin), 5, 6, and 8 days (moderate-melanin), and 2, 3, and 4 days (high-melanin). No lines were visible on day 13 for most participants in the low or moderate-melanin groups and on day 6 on most participants in the high-melanin group. The marking intensities decreased more quickly in the moderate-melanin group compared the low-melanin group.

Conclusion

Henna is an effective skin marker that can be applied through US gel where short staining wait-times result in markings lasting several days. To achieve the same durability, staining wait-times are about double for high-melanin skin tones compared to low or moderate-melanin skin tones.
目的:评价指甲花作为不同肤色的持久皮肤标记物用于超声定位,并确定实际临床工作流程中指甲花应用所需的最短时间。材料和方法:前瞻性研究,通过超声凝胶在15名健康参与者的前臂上应用7条指甲花线,这些参与者使用经过验证的六色条工具。色条分类1-2、3-4、5-6分别为低、中、高黑色素组。随后的每条线应用染色,等待时间从10到480秒不等。每2-3天用氯己定擦洗后获得系列照片,由参与者、个人和共识医生读数以及波段强度量化评估清晰可见线的数量。结果:指甲花可通过US凝胶涂抹,斑点耐洗必泰擦洗。染色等待时间为60、120和240 s, 6、8和10天(低黑色素),5、6和8天(中等黑色素),2、3和4天(高黑色素)可见线。在第13天,大多数低黑色素组或中等黑色素组的参与者没有看到线条,在第6天,大多数高黑色素组的参与者没有看到线条。与低黑色素组相比,中等黑色素组的标记强度下降得更快。结论:指甲花是一种有效的皮肤标记,可以通过美国凝胶涂抹,染色时间短,标记持续数天。为了达到同样的耐久性,高黑色素肤色的染色等待时间大约是低或中等黑色素肤色的两倍。
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引用次数: 0
Diagnostic performance and clinical outcomes of computed tomography colonography in a sick inpatient population
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-10 DOI: 10.1016/j.clinimag.2025.110401
Jessica T. Lovett , Chenchan Huang , Vinay Prabhu

Purpose

Though prior studies have proven CTC's efficacy in outpatients, its utility in the inpatient setting has not been studied. We evaluated the efficacy of a modified CTC protocol in the inpatient setting, primarily for patients awaiting organ transplantation.

Methods

This retrospective study compared a group of inpatient CTCs from 2019 to 2021 and a randomly selected, age-matched 2:1 control group of outpatient CTCs. Both groups were assessed based on established criteria from literature.

Results

10 % (63/652) of CTCs were performed in the inpatient setting, of which 29 were excluded, yielding 34 inpatient cases. 90 % (589/652) of CTCs were performed in the outpatient setting, from which 68 randomly selected, age-matched patients were selected as controls. Significantly more (24 %, 8/34) inpatients expired due to extracolonic causes (vs. 1 %, 1/68 outpatients, p < 0.05). 62 % (21/34) of inpatient CTCs were reported as diagnostic (vs. 74 %, 50/68 outpatient, p = 0.22). Significantly more inpatients (12 %, 4/34) than outpatients (1 %, 1/68) were unable to tolerate two imaging positions (p = 0.02). Subsequent colonoscopy was performed in 24 % (8/34) of inpatients, revealing pathologies including colonic polyps and non-bleeding ulcers. Inpatient CTCs had lower average quality scores, significant for one reviewer (p = 0.009–0.054). Inpatients had a larger number of segments with: >25 % residual fluid (1.22–1.28 inpatients vs. 0.60–0.73 outpatients, p = 0.003–0.026) and inadequate fluid tagging (1.10 inpatients vs. 0.49 outpatients, p = 0.046–0.0501). Distention was not significantly different between groups (p = 0.317–0.410).

Conclusion

Quality of inpatient CTC was inferior to outpatient CTCs across several metrics. 24 % undergoing inpatient CTC died of extracolonic causes within 22 months, and most did not have findings warranting intervention, questioning the value of this difficult exam in this patient population. Routine CT may be sufficient to exclude large or metastatic colonic lesions precluding transplant.
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引用次数: 0
4D flow cardiac magnetic resonance in pediatric congenital heart disease: Insights from over four years of clinical practice 4D血流心脏磁共振在小儿先天性心脏病中的应用:来自四年多临床实践的见解
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-08 DOI: 10.1016/j.clinimag.2024.110399
Kerstin Lagerstrand , Pär-Arne Svensson , Linnea Andersson , Anna Nyström , Frida Dangardt , Charlotte de Lange

Background

Congenital heart diseases (CHDs) are common birth defects. This work presents over four years of clinical experience of 4D flow cardiovascular magnetic resonance (CMR), highlighting its value for pediatric CHD.

Methods

Children with various CHD diagnoses (n = 298) were examined on a 1.5 or 3 T scanner using 4D flow CMR in free breathing with respiratory compensation. The image volume was acquired in axial orientation, covering the entire heart and major vessels. Head-to-head comparisons with reference standards were systematically performed.

Results

4D flow CMR provided more detailed insights into complex cardiovascular conditions while maintaining a comparable level of accuracy in peak velocity, Q and Qp/Qs (R = 0.9–1.0) compared to conventional 2D flow CMR. The advantages of 4D flow CMR were particularly evident for valve function, stenosis, and shunt assessments. However, our findings emphasize the need for additional corrections to address partial volume (up to 180 % error in perfusion ratio) and through-plane cardiac motion effects (up to 25/10 ml error in aortic/pulmonary regurgitation volume).

Conclusion

Overall, 4D flow CMR proved to be a comprehensive diagnostic tool that enhanced the understanding and management of pediatric CHD, potentially changing the course of the treatment.
背景:先天性心脏病(CHDs)是常见的先天性缺陷。本文介绍了4年多来心血管磁共振(CMR)的临床经验,强调了其在小儿冠心病中的价值。方法:对298例不同诊断的CHD患儿进行自由呼吸呼吸补偿4D血流CMR 1.5 T或3t扫描检查。图像体积在轴向上获得,覆盖整个心脏和主要血管。系统地进行了与参考标准的直接比较。结果:与传统的二维血流CMR相比,4D血流CMR在保持峰值流速、Q和Qp/Qs (R = 0.9-1.0)的准确度的同时,对复杂的心血管疾病提供了更详细的见解。4D血流CMR在瓣膜功能、狭窄和分流评估方面的优势尤为明显。然而,我们的研究结果强调需要额外的校正来解决部分容积(灌注比误差高达180%)和贯穿平面的心脏运动影响(主动脉/肺反流容积误差高达25/ 10ml)。结论:总的来说,4D血流CMR被证明是一种全面的诊断工具,增强了对儿童冠心病的认识和管理,有可能改变治疗过程。
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引用次数: 0
Development of an interactive ultra-high resolution magnetic resonance neurography atlas of the brachial plexus and upper extremity peripheral nerves
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-02 DOI: 10.1016/j.clinimag.2024.110400
Philip G. Colucci, Madeleine A. Gao , Ek Tsoon Tan, Sophie Queler, Marianne Belanger, Joyce Tsai, John A. Carrino, Darryl B. Sneag

Purpose

To develop an educational, interactive, ultra-high resolution, in vivo magnetic resonance (MR) neurography atlas for direct visualization of the brachial plexus and upper extremity.

Methods

A total of 16 adult volunteers without known peripheral neuropathy underwent magnetic resonance (MR) neurography of the brachial plexus and upper extremity. To improve vascular suppression, subjects received an intravenous infusion of ferumoxytol. To improve image quality, MR neurography datasets were reconstructed using a deep learning algorithm. The atlas was then developed using a web-based user-interface software, which allowed for labeling of peripheral nerves and muscles, and mapping of muscles to their respective innervation. The user interface was optimized to maximize interactivity and user-friendliness.

Results

Fifteen subjects completed at least one scan with no reported adverse reactions from the ferumoxytol infusions. Adequate vascular suppression was observed in all MR neurography datasets. The images of the brachial plexus and upper extremity included in this atlas allowed for identification and labeling of 177 unique anatomical structures from the neck to the wrist. The atlas was made freely accessible on the internet.

Conclusion

A detailed and interactive MR neurography atlas of the brachial plexus and upper extremity was successfully developed to depict small nerves and fascicular detail with unprecedented spatial and contrast resolution. This freely available online resource (https://www.hss.edu/MRNatlas) can be used as an educational tool and clinical reference. The techniques utilized in this project serve as a framework for continued work in expanding the atlas to cover other peripheral nerve territories.
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引用次数: 0
Complications related to radiofrequency ablation of lung tumors: CT findings and review 肺部肿瘤射频消融术的并发症:CT表现及回顾。
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-31 DOI: 10.1016/j.clinimag.2024.110396
José Guilherme Marranghello Maluf , José de Arimateia Batista Araujo-Filho , Guilherme Lopes Pinheiro Martins , Marcos Roberto Menezes , Tassia Regina Yamanari
Radiofrequency ablation is a treatment option for primary and secondary lung tumors, particularly in non-surgical patients. Although it is considered a safe and effective procedure, various complications can occur. Most of these adverse events are self-limiting and can be treated conservatively; however, some may be severe and require intervention. Radiologists play a pivotal role in the diagnosis and follow-up of these conditions, aiding in their early identification and management in clinical practice. They must be familiar with the expected and unexpected imaging post-procedure features. This article reviews the main complications of radiofrequency ablation of lung tumors and their associated CT findings.
射频消融是原发性和继发性肺肿瘤的治疗选择,特别是在非手术患者中。虽然它被认为是一种安全有效的手术,但可能会发生各种并发症。这些不良事件大多是自限性的,可以保守治疗;然而,有些可能是严重的,需要干预。放射科医生在这些疾病的诊断和随访中起着关键作用,在临床实践中帮助他们的早期识别和管理。他们必须熟悉预期和意外的术后影像学特征。本文综述了射频消融术治疗肺部肿瘤的主要并发症及其相关的CT表现。
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引用次数: 0
Increasing patient viewership of complex imaging reports: The paradox of the Cures Act 增加患者对复杂影像报告的观看:《治愈法案》的悖论。
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-29 DOI: 10.1016/j.clinimag.2024.110398
Kanhai S. Amin , Melissa A. Davis , Amir Naderi , Howard P. Forman

Background

As a result of the 21st Century Cures Act, radiology reports are immediately released to patients. We determine if readers of radiology reports, via electronic health records (EHRs), and radiology report complexity have changed post the implementation of the 21st Century Cures Act.

Methods

A retrospective observational study was used to analyze 10,000 radiology reports (equal split of CT, mammogram, MRI, X-ray, and ultrasound modalities) per year between 2013 and 2023. Readability was calculated through reading grade level indices.

Results

Patient viewership of their radiology reports via EHRs increased from 3.3 % (95 % CI: 3.0 %–3.7 %) in 2013 to 58.2 % (95 % CI: 57.3 %–59.2 %) in 2023. Once the 21st Century Cures Act's Information Blocking Provision went into effect, there was a significant increase in viewing probability with patients having 1.71 times higher odds of viewing their reports (OR = 1.71, 95 % CI: 1.27–2.32, p < 0.001). This increase in patient viewership held for all modalities tested except CT (P < 0.01). Despite increased viewership, the reading grade level of radiologist dictated radiology reports was greater than the recommended level for health information across all years and modalities tested.

Conclusions and relevance

Patients are increasingly engaging with their radiology reports, but reports may be too complex for the typical patient. Solutions will be required to improve patient experience with their radiology reports.
背景:根据《21世纪治愈法案》,放射学报告可以立即发布给患者。我们通过电子健康记录(EHRs)确定放射学报告的读者和放射学报告的复杂性是否在21世纪治愈法案实施后发生了变化。方法:采用回顾性观察性研究,分析2013年至2023年间每年1万份影像学报告(CT、乳房x线、MRI、x线和超声等方式)。通过阅读年级水平指标计算可读性。结果:患者通过电子病历查看放射学报告的比例从2013年的3.3% (95% CI: 3.0% - 3.7%)增加到2023年的58.2% (95% CI: 57.3% - 59.2%)。一旦《21世纪治愈法案》的信息封锁条款生效,查看概率显著增加,患者查看报告的几率增加了1.71倍(OR = 1.71, 95% CI: 1.27-2.32, p)结论和相关性:患者越来越多地参与他们的放射学报告,但报告对于典型患者来说可能过于复杂。需要解决方案来改善患者对放射报告的体验。
{"title":"Increasing patient viewership of complex imaging reports: The paradox of the Cures Act","authors":"Kanhai S. Amin ,&nbsp;Melissa A. Davis ,&nbsp;Amir Naderi ,&nbsp;Howard P. Forman","doi":"10.1016/j.clinimag.2024.110398","DOIUrl":"10.1016/j.clinimag.2024.110398","url":null,"abstract":"<div><h3>Background</h3><div>As a result of the 21st Century Cures Act, radiology reports are immediately released to patients. We determine if readers of radiology reports, via electronic health records (EHRs), and radiology report complexity have changed post the implementation of the 21st Century Cures Act.</div></div><div><h3>Methods</h3><div>A retrospective observational study was used to analyze 10,000 radiology reports (equal split of CT, mammogram, MRI, X-ray, and ultrasound modalities) per year between 2013 and 2023. Readability was calculated through reading grade level indices.</div></div><div><h3>Results</h3><div>Patient viewership of their radiology reports via EHRs increased from 3.3 % (95 % CI: 3.0 %–3.7 %) in 2013 to 58.2 % (95 % CI: 57.3 %–59.2 %) in 2023. Once the 21st Century Cures Act's Information Blocking Provision went into effect, there was a significant increase in viewing probability with patients having 1.71 times higher odds of viewing their reports (OR = 1.71, 95 % CI: 1.27–2.32, <em>p</em> &lt; 0.001). This increase in patient viewership held for all modalities tested except CT (<em>P</em> &lt; 0.01). Despite increased viewership, the reading grade level of radiologist dictated radiology reports was greater than the recommended level for health information across all years and modalities tested.</div></div><div><h3>Conclusions and relevance</h3><div>Patients are increasingly engaging with their radiology reports, but reports may be too complex for the typical patient. Solutions will be required to improve patient experience with their radiology reports.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"119 ","pages":"Article 110398"},"PeriodicalIF":1.8,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between price transparency and patient decision to complete outpatient imaging 价格透明度与患者决定完成门诊影像之间的关系。
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-27 DOI: 10.1016/j.clinimag.2024.110397
Ali Rashidi , Thao Pham , Aldo Arce , Diya Garg , Gelareh Sadigh

Purpose

The impact of price transparency on patients' decisions to receive the recommended care is unclear. This study aimed to assess the utilization rate of hospital price estimator tools for outpatient imaging appointments, and the association between price estimator utilization and subsequent imaging completion.

Methods

In this retrospective, cross-sectional study, adult patients with scheduled outpatient radiology examinations between August 2022 and 2023 at a single tertiary academic health system were included. Data regarding whether an out-of-pocket cost (OOPC) estimate was generated for the scheduled imaging exam, the estimate generation date, amount, generator (patient vs. staff), the date of first view by patients, appointment status (completed vs. missed appointment), and demographics were extracted. The association between price estimator use and imaging completion was assessed using generalized estimation equation multivariable regression models.

Results

A total of 470,422 imaging encounters (mean age: 55.6 ± 19.1; 57.5 % female; 56.3 % white) were included. Overall, 70,437 (15.0 %) OOPC estimates were generated (99.9 % by hospital staff and 0.1 % by patients). There was a higher number of self-pay patients among those with self-generated (55.8 %) vs. staff-generated (8.9 %) estimates (P < 0.001). The odds of imaging appointment completion were significantly higher when an OOPC estimate was generated (OR,1.91; 95 % CI, 1.87, 1.95), and significantly lower when the estimate was self-generated (OR,0.29; 95%CI, 0.17, 0.51).

Conclusion

Price-aware patients with staff-generated cost estimates were more likely to complete imaging. Self-pay patients were more likely to self-generate estimates, which was associated with lower likelihood of completing imaging.
目的:价格透明度对患者决定是否接受推荐治疗的影响尚不明确。本研究旨在评估医院价格估算工具在门诊影像预约中的使用率,以及价格估算工具的使用与后续影像检查完成之间的关联:在这项回顾性横断面研究中,纳入了 2022 年 8 月至 2023 年期间在一家三级学术医疗系统接受放射科门诊检查的成人患者。研究人员提取了以下方面的数据:是否为预定的影像检查生成了自付费用(OOPC)估算、估算生成日期、金额、生成者(患者与工作人员)、患者首次查看日期、预约状态(完成预约与错过预约)以及人口统计学特征。使用广义估计方程多变量回归模型评估了估价器的使用与成像完成之间的关联:结果:共纳入 470,422 次影像检查(平均年龄:55.6 ± 19.1;57.5% 为女性;56.3% 为白人)。共估算出 70,437 例(15.0%)OOPC(99.9% 由医院员工估算,0.1% 由患者估算)。在自费估算(55.8%)和员工估算(8.9%)的患者中,自费患者人数较多(P有价格意识的患者在工作人员估算费用后更有可能完成造影。自费患者更有可能自行估算费用,这与完成造影的可能性较低有关。
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引用次数: 0
MRI-derived radiomics and end-to-end deep learning models for predicting glioma ATRX status: a systematic review and meta-analysis of diagnostic test accuracy studies 预测胶质瘤ATRX状态的mri衍生放射组学和端到端深度学习模型:诊断测试准确性研究的系统回顾和荟萃分析。
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-26 DOI: 10.1016/j.clinimag.2024.110386
Amir Mahmoud Ahmadzadeh , Nima Broomand Lomer , Mohammad Amin Ashoobi , Girish Bathla , Houman Sotoudeh
We aimed to systematically review and meta-analyze the predictive value of magnetic resonance imaging (MRI)-derived radiomics/end-to-end deep learning (DL) models in predicting glioma alpha thalassemia/mental retardation syndrome X-linked (ATRX) status. We conducted a comprehensive search across four major databases—Web of Science, PubMed, Scopus, and Embase. All the studies that assessed the performance of radiomics and/or end-to-end DL models for predicting glioma ATRX status were included. Quality assessment was performed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) criteria and the METhodological RadiomICs Score (METRICS). Pooled estimates for performance metrics were calculated. I-squared was used to assess heterogeneity, while subgroup and sensitivity analyses were performed to find its potential sources. Publication bias was assessed using Deeks' funnel plots. Seventeen and eleven studies were included in the systematic review and meta-analysis, respectively. Most of the studies had a low risk of bias and low concern for applicability according to the QUADAS-2. Also, most of them had good quality according to the METRICS. Meta-analysis showed a pooled sensitivity of 0.80 (95%CI: 0.71–0.96), a specificity of 0.82 (95%CI: 0.67–0.93), a positive diagnostic likelihood ratio (DLR) of 6.77 (95%CI: 4.67–9.82), a negative DLR of 0.15 (95%CI: 0.06–0.38), a diagnostic odds ratio of 30.36 (95%CI: 15.87–58.05), and an area under the curve (AUC) of 0.92 (95%CI: 0.89–0.94). Subgroup analysis revealed significant intergroup differences based on several factors. Radiomics models can accurately predict ATRX status in gliomas, enhancing non-invasive tumor characterization and guiding treatment strategies.
我们旨在系统回顾和荟萃分析磁共振成像(MRI)衍生放射组学/端到端深度学习(DL)模型在预测神经胶质瘤α地中海贫血/智力迟钝综合征x连锁(ATRX)状态方面的预测价值。我们在四个主要数据库——web of Science、PubMed、Scopus和Embase中进行了全面的搜索。所有评估放射组学和/或端到端DL模型预测胶质瘤ATRX状态的研究都被纳入其中。采用诊断准确性研究质量评估-2 (QUADAS-2)标准和方法学放射组学评分(METRICS)进行质量评估。计算了性能指标的汇总估计。使用i平方来评估异质性,同时进行亚组分析和敏感性分析以寻找其潜在来源。采用Deeks漏斗图评估发表偏倚。系统评价和荟萃分析分别纳入了17项和11项研究。根据QUADAS-2,大多数研究具有低偏倚风险和低适用性关注。此外,根据METRICS,它们中的大多数都具有良好的质量。meta分析显示,合并敏感性为0.80 (95%CI: 0.71 ~ 0.96),特异性为0.82 (95%CI: 0.67 ~ 0.93),阳性诊断似然比(DLR)为6.77 (95%CI: 4.67 ~ 9.82),阴性诊断似然比(DLR)为0.15 (95%CI: 0.06 ~ 0.38),诊断优势比为30.36 (95%CI: 15.87 ~ 58.05),曲线下面积(AUC)为0.92 (95%CI: 0.89 ~ 0.94)。亚组分析显示基于几个因素的显著组间差异。放射组学模型可以准确预测胶质瘤中ATRX的状态,增强肿瘤的非侵入性表征,指导治疗策略。
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引用次数: 0
Predicting lymph node metastasis in thyroid cancer: systematic review and meta-analysis on the CT/MRI-based radiomics and deep learning models 预测甲状腺癌淋巴结转移:基于CT/ mri放射组学和深度学习模型的系统回顾和荟萃分析。
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-24 DOI: 10.1016/j.clinimag.2024.110392
Parya Valizadeh , Payam Jannatdoust , Delaram J. Ghadimi , Sara Bagherieh , Amir Hassankhani , Melika Amoukhteh , Paniz Adli , Ali Gholamrezanezhad

Background

Thyroid cancer, a common endocrine malignancy, has seen increasing incidence, making lymph node metastasis (LNM) a critical factor for recurrence and survival. Radiomics and deep learning (DL) advancements offer the potential for improved LNM prediction using CT and MRI, though challenges in diagnostic accuracy remain.

Methods

A systematic review and meta-analysis were conducted per established guidelines, with searches across PubMed, Scopus, Web of Science, and Embase up to February 15, 2024. Studies developing CT/MRI-based radiomics and/or DL models for preoperative LNM assessment in thyroid cancer patients were included. Data were extracted and analyzed using R software.

Results

Sixteen studies were analyzed. In internal validation sets, sensitivity was 81.1 % (95 % CI: 75.6 %–85.6 %) and specificity 76.4 % (95 % CI: 68.4 %–82.9 %). Training sets showed a sensitivity of 84.4 % (95 % CI: 81.5 %–87 %) and a specificity of 84.7 % (95 % CI: 74.4 %–91.4 %). The pooled AUC was 86 % for internal validation and 87 % for training. Handcrafted radiomics had a sensitivity of 79.4 % and specificity of 69.2 %, while DL models showed 80.8 % sensitivity and 78.7 % specificity. Subgroup analysis revealed that models for papillary thyroid cancer (PTC) had a pooled specificity of 76.3 %, while those including other or unspecified cancers showed 68.3 % specificity. Despite heterogeneity, significant differences (p = 0.037) were noted between models with and without clinical data.

Conclusion

Radiomics and DL models show promising potential for detecting LNM in thyroid cancer, particularly in PTC. However, study heterogeneity underscores the need for further research to optimize these imaging tools.
背景:甲状腺癌是一种常见的内分泌恶性肿瘤,其发病率越来越高,淋巴结转移(LNM)是影响其复发和生存的关键因素。放射组学和深度学习(DL)的进步为利用CT和MRI改进LNM预测提供了潜力,尽管在诊断准确性方面仍然存在挑战。方法:根据既定指南进行系统评价和荟萃分析,检索PubMed, Scopus, Web of Science和Embase,截止到2024年2月15日。研究开发基于CT/ mri的放射组学和/或DL模型,用于甲状腺癌患者术前LNM评估。使用R软件对数据进行提取和分析。结果:共分析了16项研究。在内部验证集中,灵敏度为81.1% (95% CI: 75.6% - 85.6%),特异性为76.4% (95% CI: 68.4% - 82.9%)。训练集的灵敏度为84.4% (95% CI: 81.5% - 87%),特异性为84.7% (95% CI: 74.4% - 91.4%)。内部验证的合并AUC为86%,培训的合并AUC为87%。手工放射组学的敏感性为79.4%,特异性为69.2%,而DL模型的敏感性为80.8%,特异性为78.7%。亚组分析显示,甲状腺乳头状癌(PTC)模型的总特异性为76.3%,而包括其他或未明确癌症的模型的特异性为68.3%。尽管存在异质性,但在有无临床资料的模型之间存在显著差异(p = 0.037)。结论:放射组学和DL模型在甲状腺癌,特别是PTC的LNM检测中具有良好的应用前景。然而,研究的异质性强调了进一步研究以优化这些成像工具的必要性。
{"title":"Predicting lymph node metastasis in thyroid cancer: systematic review and meta-analysis on the CT/MRI-based radiomics and deep learning models","authors":"Parya Valizadeh ,&nbsp;Payam Jannatdoust ,&nbsp;Delaram J. Ghadimi ,&nbsp;Sara Bagherieh ,&nbsp;Amir Hassankhani ,&nbsp;Melika Amoukhteh ,&nbsp;Paniz Adli ,&nbsp;Ali Gholamrezanezhad","doi":"10.1016/j.clinimag.2024.110392","DOIUrl":"10.1016/j.clinimag.2024.110392","url":null,"abstract":"<div><h3>Background</h3><div>Thyroid cancer, a common endocrine malignancy, has seen increasing incidence, making lymph node metastasis (LNM) a critical factor for recurrence and survival. Radiomics and deep learning (DL) advancements offer the potential for improved LNM prediction using CT and MRI, though challenges in diagnostic accuracy remain.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted per established guidelines, with searches across PubMed, Scopus, Web of Science, and Embase up to February 15, 2024. Studies developing CT/MRI-based radiomics and/or DL models for preoperative LNM assessment in thyroid cancer patients were included. Data were extracted and analyzed using R software.</div></div><div><h3>Results</h3><div>Sixteen studies were analyzed. In internal validation sets, sensitivity was 81.1 % (95 % CI: 75.6 %–85.6 %) and specificity 76.4 % (95 % CI: 68.4 %–82.9 %). Training sets showed a sensitivity of 84.4 % (95 % CI: 81.5 %–87 %) and a specificity of 84.7 % (95 % CI: 74.4 %–91.4 %). The pooled AUC was 86 % for internal validation and 87 % for training. Handcrafted radiomics had a sensitivity of 79.4 % and specificity of 69.2 %, while DL models showed 80.8 % sensitivity and 78.7 % specificity. Subgroup analysis revealed that models for papillary thyroid cancer (PTC) had a pooled specificity of 76.3 %, while those including other or unspecified cancers showed 68.3 % specificity. Despite heterogeneity, significant differences (<em>p</em> = 0.037) were noted between models with and without clinical data.</div></div><div><h3>Conclusion</h3><div>Radiomics and DL models show promising potential for detecting LNM in thyroid cancer, particularly in PTC. However, study heterogeneity underscores the need for further research to optimize these imaging tools.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"119 ","pages":"Article 110392"},"PeriodicalIF":1.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of anomalies and variants of coronary arteries: A single center study by coronary CT angiography 冠状动脉异常和变异的患病率:冠状动脉CT血管造影的单中心研究。
IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-14 DOI: 10.1016/j.clinimag.2024.110389
İsmail Yağmurhan Gilan , Kaan Esen , Yüksel Balcı , Ahmet Hakan Öztürk

Purpose

It has been demonstrated that the coronary artery anomalies (CAAs) are generally asymptomatic. However, some cases can cause severe life threatening events. As coronary computed tomography angiography (CCTA) has emerged as a non-invasive alternative to invasive coronary angiography for the evaluation of coronary anatomy, the prevalence of CAAs in CCTA may more closely reflect the true prevalence in the general population. So we aimed to review and determine the prevalence of CAAs and variants retrospectively in patients who underwent CCTA at our center.

Methods

Reports of 1802 patients who underwent CCTA at the radiology department of our university hospital were traced for CAAs. At least two independent investigators reviewed the images, which were selected for further assessment prior to final classification.

Results

One hundred and fifty two anomalies in 152 patients (8.44 %) were encountered. Origin of any coronary artery from the pulmonary trunk in 1 (0.06 %), origin of LMCA from right sinus in 1 (0.06 %), origin of right coronary artery (RCA) from left sinus in 5 (0.28 %), origin of left anterior descending artery (LAD) from right sinus in 2 (0.11 %), origin of circumflex branch (RCx) of LMCA from right sinus in 6 (0.33 %), origin of RCx from RCA in 4 (0.22 %), origin of any coronary artery from the ascending aorta in 2 (0.11 %), split RCA in 5 (0.28 %), RCx and left marginal artery from the first diagonal artery in 1 (0.06 %), myocardial bridging in 123 (6.83 %) and fistula in 2 (0.11 %) were detected as CAAs.

Conclusion

The prevalence of CAAs observed in this study was similar to the literature. CCTA can clearly visualize the anomalous origin, course and termination of the coronary artery.
目的:研究表明冠状动脉异常(CAAs)通常是无症状的。然而,有些病例会导致严重的危及生命的事件。由于冠状动脉ct血管造影(CCTA)已成为冠状动脉解剖评估的非侵入性替代侵入性冠状动脉造影,CCTA中CAAs的患病率可能更能反映普通人群的真实患病率。因此,我们的目的是回顾并确定在我们中心接受CCTA的患者中CAAs及其变异的患病率。方法:对在我院放射科行CCTA的1802例患者的CAAs进行回顾性分析。至少有两名独立调查人员审查了这些图像,这些图像在最终分类之前被选中进行进一步评估。结果:152例患者中出现152例异常,占8.44%。起源的任何冠状动脉肺动脉干1例(0.06%),LMCA起源从右窦1例(0.06%),右冠状动脉(RCA)起源从左窦在5(0.28%),左冠状动脉前降的起源(小伙子)从右窦2(0.11%),弯曲的分支起源(RCx) LMCA从右窦在6 (0.33%),RCx起源从RCA 4(0.22%),任何从升主动脉冠状动脉起源2(0.11%)、分裂RCA在5 (0.28%),1例(0.06%)、123例(6.83%)心肌桥、2例(0.11%)内瘘均为caa。结论:本研究观察到的CAAs患病率与文献相似。CCTA可以清晰地显示冠状动脉的异常起始、走行和终止。
{"title":"Prevalence of anomalies and variants of coronary arteries: A single center study by coronary CT angiography","authors":"İsmail Yağmurhan Gilan ,&nbsp;Kaan Esen ,&nbsp;Yüksel Balcı ,&nbsp;Ahmet Hakan Öztürk","doi":"10.1016/j.clinimag.2024.110389","DOIUrl":"10.1016/j.clinimag.2024.110389","url":null,"abstract":"<div><h3>Purpose</h3><div>It has been demonstrated that the coronary artery anomalies (CAAs) are generally asymptomatic. However, some cases can cause severe life threatening events. As coronary computed tomography angiography (CCTA) has emerged as a non-invasive alternative to invasive coronary angiography for the evaluation of coronary anatomy, the prevalence of CAAs in CCTA may more closely reflect the true prevalence in the general population. So we aimed to review and determine the prevalence of CAAs and variants retrospectively in patients who underwent CCTA at our center.</div></div><div><h3>Methods</h3><div>Reports of 1802 patients who underwent CCTA at the radiology department of our university hospital were traced for CAAs. At least two independent investigators reviewed the images, which were selected for further assessment prior to final classification.</div></div><div><h3>Results</h3><div>One hundred and fifty two anomalies in 152 patients (8.44 %) were encountered. Origin of any coronary artery from the pulmonary trunk in 1 (0.06 %), origin of LMCA from right sinus in 1 (0.06 %), origin of right coronary artery (RCA) from left sinus in 5 (0.28 %), origin of left anterior descending artery (LAD) from right sinus in 2 (0.11 %), origin of circumflex branch (RCx) of LMCA from right sinus in 6 (0.33 %), origin of RCx from RCA in 4 (0.22 %), origin of any coronary artery from the ascending aorta in 2 (0.11 %), split RCA in 5 (0.28 %), RCx and left marginal artery from the first diagonal artery in 1 (0.06 %), myocardial bridging in 123 (6.83 %) and fistula in 2 (0.11 %) were detected as CAAs.</div></div><div><h3>Conclusion</h3><div>The prevalence of CAAs observed in this study was similar to the literature. CCTA can clearly visualize the anomalous origin, course and termination of the coronary artery.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"119 ","pages":"Article 110389"},"PeriodicalIF":1.8,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Clinical Imaging
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