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Usefulness of extended inflammatory parameters related to neutrophil activation reported by Sysmex XN-1000 hematology analyzer for predicting complicated acute appendicitis. Comparison with canonical inflammatory laboratory tests Sysmex XN-1000 血液分析仪报告的与中性粒细胞活化有关的扩展炎症参数对预测复杂性急性阑尾炎的有用性。与典型炎症实验室测试的比较
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-06-01 DOI: 10.1016/j.ciresp.2023.11.014
María Isabel Díaz López , Elena Crespo Álvarez , Álvaro Martínez Manzano , Eloísa Urrechaga , Manuel Tomás Orgaz Morales , Mercedes González Morales , Elena Martín García , Luis García de Guadiana-Romualdo

Aim

Accurate diagnosis of complicated appendicitis is of importance to ensure that patients receive early and effective treatment, minimizing the risk of postoperative complications to promote successful recovery. Biochemical markers are a promising tool to identify complicated appendicitis. We aimed to evaluate the potential role of novel parameters related with neutrophil activation, known as “Extended Inflammation Parameters” (EIP), included in blood cell count reported by Sysmex XN-Series analyzers, compared to other canonical biomarkers in identifying complicated appendicitis.

Method

Prospective observational study including patients with confirmed diagnosis of acute appendicitis. C-reactive protein (CRP), procalcitonin, cell blood count, including white blood cell (WBC), absolute neutrophil (ANC) and immature granulocyte (IG) count and EIP (neutrophil reactivity [NEUT-RI] and granularity intensity [NEUT-GI]) were analyzed before surgery. Their accuracy to diagnose complicated appendicitis was tested in an ROC curve analysis.

Results

Our population study included 119 patients, and appendicitis was complicated in 58 (48.7%). NLR, CRP and procalcitonin levels, ANC and IG count and NEUT-RI and NEUT-GI were higher in patients with complicated appendicitis. Regarding accuracy for complicated appendicitis, CRP was the biomarker with the highest performance (ROC AUC: 0.829), with an optimal cutoff of 73.1 mg/L (sensitivity: 63.8%, specificity: 88.5%). NEUT-RI and NEUT-GI achieved both significant but poor accuracy, with ROC AUC of 0.606 and 0.637, respectively.

Conclusions

Novel laboratory tests reported by Sysmex XN-Series analyzers have poor accuracy for identifying complicated appendicitis. In this study, CRP was the biomarker with the highest performance and may be useful as predictor of the severity of acute appendicitis.

目的准确诊断复杂性阑尾炎对确保患者及早接受有效治疗、最大限度降低术后并发症风险、促进患者顺利康复至关重要。生化指标是鉴别复杂性阑尾炎的有效工具。我们的目的是评估 Sysmex XN 系列分析仪报告的血细胞计数中包含的与中性粒细胞活化有关的新参数(称为 "扩展炎症参数"(EIP))与其他典型生物标记物相比在鉴别复杂性阑尾炎方面的潜在作用。手术前对 C 反应蛋白(CRP)、降钙素原、细胞计数(包括白细胞(WBC)、绝对中性粒细胞(ANC)和未成熟粒细胞(IG)计数)和 EIP(中性粒细胞反应性 [NEUT-RI] 和粒度强度 [NEUT-GI])进行分析。结果我们的研究共纳入 119 例患者,其中 58 例(48.7%)为复杂性阑尾炎。复杂性阑尾炎患者的 NLR、CRP 和降钙素原水平、ANC 和 IG 计数以及 NEUT-RI 和 NEUT-GI 均较高。就复杂性阑尾炎的准确性而言,CRP 是性能最高的生物标志物(ROC AUC:0.829),最佳临界值为 73.1 mg/L(灵敏度:63.8%,特异性:88.5%)。结论Sysmex XN 系列分析仪报告的新型实验室检测项目在鉴别复杂性阑尾炎方面的准确性较差。在这项研究中,CRP是性能最高的生物标志物,可用于预测急性阑尾炎的严重程度。
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引用次数: 0
Magnetic liver retraction in bariatric surgery: Is it possible? 减肥手术中的磁性肝回缩:可行吗?
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-06-01 DOI: 10.1016/j.ciresp.2024.02.010
Guillermo Borjas, Ali Urdaneta, Eduardo Ramos, Andrés Maldonado

One of the recent advances in bariatric surgery is the use of magnetic devices. This research paper describes magnetic liver retraction in morbidly obese patients during bariatric surgery. A descriptive, prospective and observational study was carried out, analyzing 100 patients in whom magnetic retraction was used. Mean and SD body mass index was 46.1 ± 5.09 kg/m2. The magnetic system was successfully used for liver retraction in 95% of cases; in only 5% of cases was its use not possible due to hepatomegaly and severe hepatic steatosis. According to the results, magnetic liver retraction can be safe and used in bariatric surgery, regardless of body mass index and with a low percentage of complications.

减肥手术的最新进展之一是使用磁性装置。这篇研究论文介绍了在减肥手术中对病态肥胖患者进行磁性肝脏牵引的情况。该研究是一项描述性、前瞻性和观察性研究,分析了100名使用磁性牵引的患者。平均体重指数(46.1 ± 5.09 kg/m2)和标準体重指数(46.1 ± 5.09 kg/m2)。95%的病例成功使用了磁力系统进行肝脏牵引,只有5%的病例因肝脏肿大和严重肝脏脂肪变性而无法使用磁力系统。研究结果表明,无论体重指数如何,磁力牵引肝脏都可以安全地用于减肥手术,而且并发症发生率较低。
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引用次数: 0
Economic impact of outpatient follow-up using telemedicine vs in-person visits for patients in general surgery: A secondary analysis of a randomized clinical trial 对普外科患者使用远程医疗与亲临现场进行门诊随访的经济影响:随机临床试验的二次分析
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-06-01 DOI: 10.1016/j.ciresp.2024.01.017
Georgina Ferret , Manel Cremades , Lídia Cornejo , Francesc Guillem-López , Ramon Farrés , David Parés , Joan-Francesc Julian

Introduction

Innovation in internet connectivity and the Covid 19 pandemic have caused a dramatic change in the management of patients in the medical field, boosting the use of telemedicine. A comparison of clinical outcomes and satisfaction between conventional face-to-face and telemedicine follow-up in general surgery, an economic evaluation is mandatory.

The aim of the present study was to compare the differences in economic costs between these two outpatient approaches in a designed randomized controlled trial (RCT).

Methods

A RCT was conducted enrolling 200 patients to compare conventional in-person vs. digital health follow-up using telemedicine in the outpatient clinics in patients of General Surgery Department after their planned discharge. After a demonstration that no differences were found in clinical outcomes and patient satisfaction, we analyzed the medical costs, including staff wages, initial investment, patent’s transportation and impact on social costs.

Results

After an initial investment of 7527.53€, the costs for the Medical institution of in-person conventional follow-up were higher (8180.4€) than those using telemedicine (4630.06€). In relation to social costs, loss of productivity was also increased in the conventional follow-up.

Conclusion

The use of digital Health telemedicine is a cost-effective approach compared to conventional face-to-face follow-up in patients of General Surgery after hospital discharge.

导言:互联网连接的创新和 Covid 19 的流行给医疗领域的患者管理带来了巨大变化,促进了远程医疗的使用。本研究的目的是在一项随机对照试验(RCT)中比较这两种门诊方法在经济成本上的差异。研究方法在普外科门诊病人计划出院后进行了一项 RCT 试验,招募了 200 名病人,比较传统的面对面随访与使用远程医疗的数字健康随访。在证明临床结果和患者满意度无差异后,我们分析了医疗成本,包括员工工资、初始投资、专利交通和对社会成本的影响。结果在初始投资 7527.53 欧元后,医疗机构的传统面对面随访成本(8180.4 欧元)高于使用远程医疗的成本(4630.06 欧元)。结论与传统的面对面随访相比,对出院后的普通外科患者使用数字健康远程医疗是一种具有成本效益的方法。
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引用次数: 0
Carcinoma pulmonar asociado a quiste aéreo: importancia del seguimiento para el diagnóstico temprano 气囊相关肺癌:早期诊断随访的重要性
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-06-01 DOI: 10.1016/j.ciresp.2023.10.014
Julio Ricardo Torres Bermúdez , Cora Andrea Sampedro Salinas , Sonia Gatius Calderó , Carlos A. Rombolá
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引用次数: 0
Fístula arterio-entérica en paciente con trasplante pancreato-renal 胰肾移植患者的肠动脉瘘
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-06-01 DOI: 10.1016/j.ciresp.2023.09.006
Renan Carlo Colombari , María Fernández Martínez , Fernando García Boyano , Álvaro Morales Taboada
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引用次数: 0
Lipoblastoma retroperitoneal del adulto: una entidad poco frecuente con presentación atípica 成人腹膜后脂肪母细胞瘤:表现不典型的罕见病例
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-06-01 DOI: 10.1016/j.ciresp.2023.09.007
Montiel Jiménez Fuertes, Víctor Domínguez Prieto, Siyuan Qian, Pablo Pastor Riquelme, Pedro Villarejo Campos
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引用次数: 0
Diagnóstico diferencial de tumor retroperitoneal: hematoma crónico suprarrenal, un diagnóstico infrecuente 腹膜后肿瘤的鉴别诊断:慢性肾上腺血肿,一种罕见诊断
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.ciresp.2023.09.005
Álvaro Soler-Silva, Verónica Aranaz-Ostáriz, Sandra Lario Pérez, José Antonio Barreras
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引用次数: 0
¿Hemos mejorado los resultados posoperatorios y a largo plazo de la hepatectomía por metástasis de cáncer colorrectal? Análisis de 1.736 hepatectomías realizadas a lo largo de tres décadas en un solo centro 我们是否改善了结直肠癌转移肝切除术的术后和长期疗效?对一家中心三十年来进行的 1,736 例肝切除术进行分析。
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.ciresp.2023.11.012
Kristel Mils , Laura Lladó , Josefina Lopez-Dominguez , Oriana Barrios , David Leiva , Cristina Santos , Teresa Serrano , Emilio Ramos

Introduction

Surgery is the only potentially curative treatment for colorectal cancer liver metastases (CRCLM) and its indication and results have varied in the last 30 years.

Methods

All patients operated on for CRCLM in our center from 1990 to 2021 were prospectively collected, establishing three subgroups based on the year of the first surgery: group A 1990–1999, group B 2000–2010, group C 2011–2021. Clinical characteristics and the results of survival, recurrence and prognostic factors were compared.

Results

One thousand seven hundred thirty-six hepatectomies were included (Group A n = 208; Group B n = 770; Group C n = 758). Patients in group C had better survival at 5 and 10 years (A 40.5%/28.2%; B 45.9%/32.2%; C 51.6%/33.1%, p = 0.013), although there were no differences between groups in overall recurrence at 5 and 10 years (A 73%/75.7%; B 67.6%/69.2%, and C 63.9%/66%, p = 0.524), nor in liver recurrence (A 46.4%/48.2%; B 45.8%/48.2%; and C 44.4%/48.4%, p = 0.899). An improvement was observed in median survival after recurrence, being 19 months, 23 months, and 31 months (groups A, B and C respectively). Prognostic factors of long-term survival changed over the three study periods. The only ones that remained relevant in the last decade were the presence of > 4 liver metastasis, extrahepatic disease at the time of hepatectomy, and intraoperative blood transfusion.

Conclusions

Survival after surgery for CRCLM has improved significantly, although this cannot be explained by a reduction in overall and hepatic recurrence, but rather by an improvement in post-recurrence survival. Involvement of the resection margin has lost prognostic value in the last decade.

方法前瞻性收集本中心1990年至2021年期间所有接受过CRCLM手术的患者,根据首次手术的年份建立三个亚组:A组1990-1999年,B组2000-2010年,C组2011-2021年。结果 共纳入 1736 例肝癌切除术(A 组 208 例;B 组 770 例;C 组 758 例)。C组患者5年和10年的存活率更高(A组40.5%/28.2%;B组45.9%/32.2%;C组51.6%/33.1%,P = 0.013),但5年和10年的总复发率组间无差异(A组73%/75.7%; B 67.6%/69.2%; C 63.9%/66%, p = 0.524),肝脏复发率(A 46.4%/48.2%; B 45.8%/48.2%; C 44.4%/48.4%, p = 0.899)也没有差异。复发后的中位生存期有所改善,分别为 19 个月、23 个月和 31 个月(A 组、B 组和 C 组)。长期生存的预后因素在三个研究期间都发生了变化。结论CRCLM术后生存率显著提高,但这不能归因于总复发率和肝复发率的降低,而是复发后生存率的提高。在过去十年中,切除边缘受累已失去预后价值。
{"title":"¿Hemos mejorado los resultados posoperatorios y a largo plazo de la hepatectomía por metástasis de cáncer colorrectal? Análisis de 1.736 hepatectomías realizadas a lo largo de tres décadas en un solo centro","authors":"Kristel Mils ,&nbsp;Laura Lladó ,&nbsp;Josefina Lopez-Dominguez ,&nbsp;Oriana Barrios ,&nbsp;David Leiva ,&nbsp;Cristina Santos ,&nbsp;Teresa Serrano ,&nbsp;Emilio Ramos","doi":"10.1016/j.ciresp.2023.11.012","DOIUrl":"10.1016/j.ciresp.2023.11.012","url":null,"abstract":"<div><h3>Introduction</h3><p>Surgery is the only potentially curative treatment for colorectal cancer liver metastases (CRCLM) and its indication and results have varied in the last 30 years.</p></div><div><h3>Methods</h3><p>All patients operated on for CRCLM in our center from 1990 to 2021 were prospectively collected, establishing three subgroups based on the year of the first surgery: group A 1990–1999, group B 2000–2010, group C 2011–2021. Clinical characteristics and the results of survival, recurrence and prognostic factors were compared.</p></div><div><h3>Results</h3><p>One thousand seven hundred thirty-six hepatectomies were included (Group A <em>n</em> <!-->=<!--> <!-->208; Group B <em>n</em> <!-->=<!--> <!-->770; Group C <em>n</em> <!-->=<!--> <!-->758). Patients in group C had better survival at 5 and 10 years (A 40.5%/28.2%; B 45.9%/32.2%; C 51.6%/33.1%, <em>p</em> <!-->=<!--> <!-->0.013), although there were no differences between groups in overall recurrence at 5 and 10 years (A 73%/75.7%; B 67.6%/69.2%, and C 63.9%/66%, <em>p</em> <!-->=<!--> <!-->0.524), nor in liver recurrence (A 46.4%/48.2%; B 45.8%/48.2%; and C 44.4%/48.4%, <em>p</em> <!-->=<!--> <!-->0.899). An improvement was observed in median survival after recurrence, being 19 months, 23 months, and 31 months (groups A, B and C respectively). Prognostic factors of long-term survival changed over the three study periods. The only ones that remained relevant in the last decade were the presence of &gt; 4 liver metastasis, extrahepatic disease at the time of hepatectomy, and intraoperative blood transfusion.</p></div><div><h3>Conclusions</h3><p>Survival after surgery for CRCLM has improved significantly, although this cannot be explained by a reduction in overall and hepatic recurrence, but rather by an improvement in post-recurrence survival. Involvement of the resection margin has lost prognostic value in the last decade.</p></div>","PeriodicalId":50690,"journal":{"name":"Cirugia Espanola","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139827670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cephalic duodenopancreatectomy in a patient with preduodenal portal vein and SADI-S bypass 为一名十二指肠前门静脉和 SADI-S 分流患者实施头十二指肠切除术
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.ciresp.2023.10.012
Enrique Rojo Villardón , Víctor Domínguez Prieto , Siyuan Qian Zhang , Santos Jiménez-Galanes Marchán
{"title":"Cephalic duodenopancreatectomy in a patient with preduodenal portal vein and SADI-S bypass","authors":"Enrique Rojo Villardón ,&nbsp;Víctor Domínguez Prieto ,&nbsp;Siyuan Qian Zhang ,&nbsp;Santos Jiménez-Galanes Marchán","doi":"10.1016/j.ciresp.2023.10.012","DOIUrl":"https://doi.org/10.1016/j.ciresp.2023.10.012","url":null,"abstract":"","PeriodicalId":50690,"journal":{"name":"Cirugia Espanola","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140822859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-traumatic cholecystocutaneous fistula of the thoracic wall 胸壁创伤后胆囊皮肤瘘
IF 1.9 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.ciresp.2023.10.011
Ana María Gómez-Gago, Begoña de las Heras-Marqués, Francisco Hernández-Escobar, Florencio Quero-Valenzuela
{"title":"Post-traumatic cholecystocutaneous fistula of the thoracic wall","authors":"Ana María Gómez-Gago,&nbsp;Begoña de las Heras-Marqués,&nbsp;Francisco Hernández-Escobar,&nbsp;Florencio Quero-Valenzuela","doi":"10.1016/j.ciresp.2023.10.011","DOIUrl":"https://doi.org/10.1016/j.ciresp.2023.10.011","url":null,"abstract":"","PeriodicalId":50690,"journal":{"name":"Cirugia Espanola","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Cirugia Espanola
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