Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0340-9
A. Doronjski, T. Stojilković, Slobodan D Spasojevic, B. Milanović, V. Stojanović
TRAP (Twin Reversed Arterial Perfusion) sequence is a rare malformation that occurs in monozygotic twin pregnancies. Twin weight ratio in our case was 76% (body weight of pump twin was 1800 g, acardiac twin 1370 g), but in spite of that the pump twin had a mild clinical picture with premature birth, fetal hydrops (mild pleural effusion; hypoproteinemia; on the 3rd day of life the baby was without edema and the level of his serum proteins were in referral ranges) and mild myocardial hypertrophy of left ventricle (echocardiography performed on the 28th day of life was normal).
{"title":"TRAP (Twin Reversed Arterial Perfusion) sequence","authors":"A. Doronjski, T. Stojilković, Slobodan D Spasojevic, B. Milanović, V. Stojanović","doi":"10.2478/s11536-013-0340-9","DOIUrl":"https://doi.org/10.2478/s11536-013-0340-9","url":null,"abstract":"TRAP (Twin Reversed Arterial Perfusion) sequence is a rare malformation that occurs in monozygotic twin pregnancies. Twin weight ratio in our case was 76% (body weight of pump twin was 1800 g, acardiac twin 1370 g), but in spite of that the pump twin had a mild clinical picture with premature birth, fetal hydrops (mild pleural effusion; hypoproteinemia; on the 3rd day of life the baby was without edema and the level of his serum proteins were in referral ranges) and mild myocardial hypertrophy of left ventricle (echocardiography performed on the 28th day of life was normal).","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"491-494"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0340-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68852320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0290-2
D. Schveigert, S. Cicėnas, Jaroslav Bublevič, Renatas Aškinis, V. Šapoka, J. Didziapetriene
The development of non-small-cell lung cancer (NSCLC) is a multistep process, which is triggered and maintained by various factors. Many steps of non-small-cell lung carcinogenesis, risk factors and biomarkers have been identified; however no consistent model has been established of personalized medicine for these patients. Distinct various gene expression, products of mutated genes and other markers such as circulating nucleic acids or tumor cells has been proven to be potential biomarkers of non-small cell lung cancer as well as potential targets for new treatment strategies. This article will highlight promising biomarkers in non-small cell lung cancer prognosis.
{"title":"The role of genetic and other biomarkers in NSCLC prognosis","authors":"D. Schveigert, S. Cicėnas, Jaroslav Bublevič, Renatas Aškinis, V. Šapoka, J. Didziapetriene","doi":"10.2478/s11536-013-0290-2","DOIUrl":"https://doi.org/10.2478/s11536-013-0290-2","url":null,"abstract":"The development of non-small-cell lung cancer (NSCLC) is a multistep process, which is triggered and maintained by various factors. Many steps of non-small-cell lung carcinogenesis, risk factors and biomarkers have been identified; however no consistent model has been established of personalized medicine for these patients. Distinct various gene expression, products of mutated genes and other markers such as circulating nucleic acids or tumor cells has been proven to be potential biomarkers of non-small cell lung cancer as well as potential targets for new treatment strategies. This article will highlight promising biomarkers in non-small cell lung cancer prognosis.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"382-390"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0290-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0304-0
T. Kitova, K. Kilova, B. Kitov, A. Masmoudi, D. Milkov, S. Gaigi
Abstract. Meckel-Gruber syndrome (MKS) is an autosomal recessive lethal malformation. As far as we know, the rate of incidence for the syndrome is 0.02 per 10,000 births. It is estimated that Meckel-Gruber syndrome accounts for 5% of all neural tube defects in Finland. Objective. The aim of this study is to present a case of a fetus with Meckel-Gruber syndrome associated with complete left isomerism. Method. The fetus was obtained after medical interruption of the pregnancy during the fifteenth gestational week. The mother was 36 years old and in a consanguineous marriage. The antenatal ultrasound examination revealed a polymalformative syndrome, leading to a postmortem examination. The fetopathological study of the fetus was conducted at the Centre for Maternity and Neonatology, Tunis, Tunisia, in 2008. Results. The female fetus had a significantly deformed ballooning abdomen, pes equinovarus, flexion of the wrist and a total posterior cleft palate. The central nervous system abnormalities were occipital encephalocele, cystic dilatation of the fourth ventricle, agenesis of corpus callosum and hydrocephalus. The study of the internal organs found dextrocardia, irregular lobulation of the lungs, left isomerism, and polysplenia. The microscopic examination revealed bilateral cystic dilation of the kidneys, fibrous proliferation of the liver and ectasic dilatation of the billiary ducts, representing a ductal plate malformation of the liver. Conclusion. The case is diagnosed with Meckel-Gruber syndrome associated with complete left isomerism, cleft palate and possibly Dandy-Walker syndrome.
{"title":"A fetus with meckel-gruber syndrome associated with isomerism","authors":"T. Kitova, K. Kilova, B. Kitov, A. Masmoudi, D. Milkov, S. Gaigi","doi":"10.2478/s11536-013-0304-0","DOIUrl":"https://doi.org/10.2478/s11536-013-0304-0","url":null,"abstract":"Abstract. Meckel-Gruber syndrome (MKS) is an autosomal recessive lethal malformation. As far as we know, the rate of incidence for the syndrome is 0.02 per 10,000 births. It is estimated that Meckel-Gruber syndrome accounts for 5% of all neural tube defects in Finland. Objective. The aim of this study is to present a case of a fetus with Meckel-Gruber syndrome associated with complete left isomerism. Method. The fetus was obtained after medical interruption of the pregnancy during the fifteenth gestational week. The mother was 36 years old and in a consanguineous marriage. The antenatal ultrasound examination revealed a polymalformative syndrome, leading to a postmortem examination. The fetopathological study of the fetus was conducted at the Centre for Maternity and Neonatology, Tunis, Tunisia, in 2008. Results. The female fetus had a significantly deformed ballooning abdomen, pes equinovarus, flexion of the wrist and a total posterior cleft palate. The central nervous system abnormalities were occipital encephalocele, cystic dilatation of the fourth ventricle, agenesis of corpus callosum and hydrocephalus. The study of the internal organs found dextrocardia, irregular lobulation of the lungs, left isomerism, and polysplenia. The microscopic examination revealed bilateral cystic dilation of the kidneys, fibrous proliferation of the liver and ectasic dilatation of the billiary ducts, representing a ductal plate malformation of the liver. Conclusion. The case is diagnosed with Meckel-Gruber syndrome associated with complete left isomerism, cleft palate and possibly Dandy-Walker syndrome.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"481-484"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0304-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0295-x
Nina Mlakar, Z. Pavlica, M. Petelin, J. Štrancar, P. Zrimšek, A. Pavlič
Animal teeth are a common model in studies on dentin adhesive materials. The aim of this study was to compare microstructural parameters (density and diameter of dentinal tubules (DT), peritubular dentin (PTD) thickness, PTD and intertubular dentin (ITD) surface area) and chemical characteristics of canine, porcine, equine, and human root dentin. The middle layers of dentin were harvested just below a cemento-enamel junction from incisors and investigated by means of scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDXS). SEM evaluation of the specimens revealed, that porcine dentin shared most similarities with human dentin. When comparing the density of DTs, canine dentin was also found to be similar to human dentin. Elemental composition of the root dentin did not differ significantly in porcine, equine and human dentin, but in canine dentin higher magnesium value in PTD compared to ITD was found. It is known that microstructural and chemical characteristics affect the strength of the adhesive bonds created among restorative materials and dentin. According to the results of this study, porcine dentin seems to be the most appropriate model to study dental materials to be used in human restorative dentistry.
{"title":"Animal and human dentin microstructure and elemental composition","authors":"Nina Mlakar, Z. Pavlica, M. Petelin, J. Štrancar, P. Zrimšek, A. Pavlič","doi":"10.2478/s11536-013-0295-x","DOIUrl":"https://doi.org/10.2478/s11536-013-0295-x","url":null,"abstract":"Animal teeth are a common model in studies on dentin adhesive materials. The aim of this study was to compare microstructural parameters (density and diameter of dentinal tubules (DT), peritubular dentin (PTD) thickness, PTD and intertubular dentin (ITD) surface area) and chemical characteristics of canine, porcine, equine, and human root dentin. The middle layers of dentin were harvested just below a cemento-enamel junction from incisors and investigated by means of scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDXS). SEM evaluation of the specimens revealed, that porcine dentin shared most similarities with human dentin. When comparing the density of DTs, canine dentin was also found to be similar to human dentin. Elemental composition of the root dentin did not differ significantly in porcine, equine and human dentin, but in canine dentin higher magnesium value in PTD compared to ITD was found. It is known that microstructural and chemical characteristics affect the strength of the adhesive bonds created among restorative materials and dentin. According to the results of this study, porcine dentin seems to be the most appropriate model to study dental materials to be used in human restorative dentistry.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"468-476"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0295-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0302-2
Deepak J. Pattanshetty, P. Bhat
Left gastric artery pseudoaneurysm is a rare but important life-threatening complication of chronic pancreatitis. We report a case of a 54-year-old male with chronic pancreatitis who presented with history of severe abdominal pain. Following an initial suspicion of acute pancreatitis, a computed tomography of abdomen was obtained that showed a large left gastric artery pseudoaneurysm (4×4 cm) with circumferential thrombosis. The patient then underwent successful angiographic coiling of the aneurysm, thus preventing a potentially life-threatening hemorrhage. In conclusion, in patients with a history of chronic pancreatitis who present with abdominal pain, a high index of suspicion should be maintained for alternate causes of abdominal pain such as visceral aneurysms involving left gastric artery. Early recognition is critical and consequences of missing these lesions can be catastrophic.
{"title":"Left gastric artery pseudoaneurysm as a sequelae of chronic pancreatitis: recognizing a life-threatening complication","authors":"Deepak J. Pattanshetty, P. Bhat","doi":"10.2478/s11536-013-0302-2","DOIUrl":"https://doi.org/10.2478/s11536-013-0302-2","url":null,"abstract":"Left gastric artery pseudoaneurysm is a rare but important life-threatening complication of chronic pancreatitis. We report a case of a 54-year-old male with chronic pancreatitis who presented with history of severe abdominal pain. Following an initial suspicion of acute pancreatitis, a computed tomography of abdomen was obtained that showed a large left gastric artery pseudoaneurysm (4×4 cm) with circumferential thrombosis. The patient then underwent successful angiographic coiling of the aneurysm, thus preventing a potentially life-threatening hemorrhage. In conclusion, in patients with a history of chronic pancreatitis who present with abdominal pain, a high index of suspicion should be maintained for alternate causes of abdominal pain such as visceral aneurysms involving left gastric artery. Early recognition is critical and consequences of missing these lesions can be catastrophic.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"370-373"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0302-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68851217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0292-0
Chun-yan Yang, P. Xu, Yu-jun Yang, Bao-yun Li, Shiliand Sun, Qiao-zhi Yang, Le-Xin Wang
The aim of this study was to describe the clinical features, management strategies and outcomes of 31 infants with systemic capillary leak syndrome (SCLS) secondary to sepsis or systemic inflammatory response syndrome. There were 23 boys and 8 girls, with an average age 9.6 ± 2.1 days (range, 3.1 to 20 days). The primary disease was pneumonia in 11 patients and sepsis in other 20. Within 72 hrs of admission, all had progressive skin and mucosal edema, septic shock, respiratory distress, oliguria and severe hypoalbuminemia (10–20g/L). Other complications were pulmonary edema or hemorrhage, disseminated intravascular coagulopathy, heart failure, renal or liver dysfunction. All patients were treated with mechanical ventilation with a mean mechanical ventilation time of 19.7± 3.5 days. Intravenous hydroxyethyl starch was also applied at an early stage for 4–12 days, together with broad spectrum antibiotics, plasma and albumin infusion. Twenty one patients (67.0%) were discharged from the neonatal intensive care unit after a median stay of 29 days, and 7 died (37.0%) in the hospital. During a 6.3-month follow-up, 4 patients had hydrocephalus and another 4 had muscle spasm or rigidity in the lower-limbs. We conclude that SCLS is a serious complication of neonatal sepsis with a high rate of in-hospital mortality and post-discharge disability.
{"title":"Systemic capillary leak syndrome due to systemic inflammatory response syndrome in infants: a report on 31 patients","authors":"Chun-yan Yang, P. Xu, Yu-jun Yang, Bao-yun Li, Shiliand Sun, Qiao-zhi Yang, Le-Xin Wang","doi":"10.2478/s11536-013-0292-0","DOIUrl":"https://doi.org/10.2478/s11536-013-0292-0","url":null,"abstract":"The aim of this study was to describe the clinical features, management strategies and outcomes of 31 infants with systemic capillary leak syndrome (SCLS) secondary to sepsis or systemic inflammatory response syndrome. There were 23 boys and 8 girls, with an average age 9.6 ± 2.1 days (range, 3.1 to 20 days). The primary disease was pneumonia in 11 patients and sepsis in other 20. Within 72 hrs of admission, all had progressive skin and mucosal edema, septic shock, respiratory distress, oliguria and severe hypoalbuminemia (10–20g/L). Other complications were pulmonary edema or hemorrhage, disseminated intravascular coagulopathy, heart failure, renal or liver dysfunction. All patients were treated with mechanical ventilation with a mean mechanical ventilation time of 19.7± 3.5 days. Intravenous hydroxyethyl starch was also applied at an early stage for 4–12 days, together with broad spectrum antibiotics, plasma and albumin infusion. Twenty one patients (67.0%) were discharged from the neonatal intensive care unit after a median stay of 29 days, and 7 died (37.0%) in the hospital. During a 6.3-month follow-up, 4 patients had hydrocephalus and another 4 had muscle spasm or rigidity in the lower-limbs. We conclude that SCLS is a serious complication of neonatal sepsis with a high rate of in-hospital mortality and post-discharge disability.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"477-480"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0292-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0300-4
S. Mahmood, M. Sivoňová, T. Matáková, D. Dobrota, L. Wsólová, A. Dzian, D. Mistuna
During the transformation process single nucleotide polymorphisms (SNPs) of key genes, such as p53 Arg72Pro or EGF A61G, may mediate various cellular processes. These variants may be associated with colorectal cancer risk (CRC), but conflicting findings have been reported. The purpose of this study was to determine the association of the SNPs in 5′ UTR of EGF A61G and p53 Arg72Pro and CRC in the Slovak population. The present case-control study was carried out in 173 confirmed CRC patients and 303 healthy subjects. Genotyping was performed by PCR-RFLP methods. Significant association was observed between age and CRC risk (p=0.001). Lower CRC risk was seen in younger patients carrying genotype p53 Arg72Pro (0.14; 95% CI 0.02–0.99, p=0.049). Gender-stratified analysis showed a significant inverse association of the polymorphism EGF G61G with CRC risk (0.48; 95% CI 0.2–0.9, p=0.04) only in male patients. Tumour site genotype distribution revealed that female patients with localized colon cancer were significantly associated with p53 Pro72Pro genotype (4.0; 95% CI 1.27–12.7, p=0.04) whereas the cancer of rectosigmoid junction was associated with the EGF G61G genotype (4.5; 95% CI 1.2–16.97, p=0.02). Combination of p53 Arg72Pro or EGF A61G polymorphisms were not associated with CRC risk by using logistic regression.
在转化过程中，关键基因如p53 Arg72Pro或EGF A61G的单核苷酸多态性(snp)可能介导多种细胞过程。这些变异可能与结直肠癌风险(CRC)有关，但报道的结果相互矛盾。本研究的目的是确定斯洛伐克人群中EGF A61G和p53 Arg72Pro 5 ' UTR snp与CRC的关系。本研究在173例确诊的结直肠癌患者和303名健康受试者中进行。采用PCR-RFLP方法进行基因分型。年龄与结直肠癌风险之间存在显著相关性(p=0.001)。携带基因型p53 Arg72Pro的年轻患者患结直肠癌的风险较低(0.14;95% CI 0.02 ~ 0.99, p=0.049)。性别分层分析显示，EGF G61G多态性与结直肠癌风险呈显著负相关(0.48;95% CI 0.2-0.9, p=0.04)，仅在男性患者中存在。肿瘤部位基因型分布显示，女性局限性结肠癌患者与p53 Pro72Pro基因型显著相关(4.0;95% CI 1.27-12.7, p=0.04)，而直肠乙状结肠结癌与EGF G61G基因型相关(4.5;95% CI 1.2 ~ 16.97, p=0.02)。通过逻辑回归分析，p53 Arg72Pro或EGF A61G多态性的组合与结直肠癌风险无关。
{"title":"Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population","authors":"S. Mahmood, M. Sivoňová, T. Matáková, D. Dobrota, L. Wsólová, A. Dzian, D. Mistuna","doi":"10.2478/s11536-013-0300-4","DOIUrl":"https://doi.org/10.2478/s11536-013-0300-4","url":null,"abstract":"During the transformation process single nucleotide polymorphisms (SNPs) of key genes, such as p53 Arg72Pro or EGF A61G, may mediate various cellular processes. These variants may be associated with colorectal cancer risk (CRC), but conflicting findings have been reported. The purpose of this study was to determine the association of the SNPs in 5′ UTR of EGF A61G and p53 Arg72Pro and CRC in the Slovak population. The present case-control study was carried out in 173 confirmed CRC patients and 303 healthy subjects. Genotyping was performed by PCR-RFLP methods. Significant association was observed between age and CRC risk (p=0.001). Lower CRC risk was seen in younger patients carrying genotype p53 Arg72Pro (0.14; 95% CI 0.02–0.99, p=0.049). Gender-stratified analysis showed a significant inverse association of the polymorphism EGF G61G with CRC risk (0.48; 95% CI 0.2–0.9, p=0.04) only in male patients. Tumour site genotype distribution revealed that female patients with localized colon cancer were significantly associated with p53 Pro72Pro genotype (4.0; 95% CI 1.27–12.7, p=0.04) whereas the cancer of rectosigmoid junction was associated with the EGF G61G genotype (4.5; 95% CI 1.2–16.97, p=0.02). Combination of p53 Arg72Pro or EGF A61G polymorphisms were not associated with CRC risk by using logistic regression.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"405-416"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0300-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0289-8
C. Nicula, D. Nicula, M. Blidaru, A. Ghiţuică, S. Neamţu, A. Saplonţai-Pop
The orbital rhabdomyosarcoma is one of the most frequent malignant orbital tumours in children. At this age, the common histological types are the embryonal and alveolar type. The onset is mainly under the age of 16. Without a recent and correct treatment it can give metastasis in lung and bone. The hereby paper presents one clinical case of a teenager presented at the ophthalmological consultation for a small tumor located in the superomedial part of the orbit. Computed tomography (CT) and magnetic resonance imaging (MRI) supported the diagnosis revealing the location and extension of the tumor. During the surgery, we discovered two small tumors and the histological examination revealed an embryonal type of orbital rhabdomyosarcoma. After the surgery, the patient followed an oncological treatment consisting of chemotherapy and local radiotherapy. The prognosis for life was favorable, linked with the recent diagnosis and treatment, the histological type and the good response at the oncological treatment.
{"title":"Orbital Rhabdomyosarcoma with a good life prognosis after surgical treatment in a 14-year-old patient","authors":"C. Nicula, D. Nicula, M. Blidaru, A. Ghiţuică, S. Neamţu, A. Saplonţai-Pop","doi":"10.2478/s11536-013-0289-8","DOIUrl":"https://doi.org/10.2478/s11536-013-0289-8","url":null,"abstract":"The orbital rhabdomyosarcoma is one of the most frequent malignant orbital tumours in children. At this age, the common histological types are the embryonal and alveolar type. The onset is mainly under the age of 16. Without a recent and correct treatment it can give metastasis in lung and bone. The hereby paper presents one clinical case of a teenager presented at the ophthalmological consultation for a small tumor located in the superomedial part of the orbit. Computed tomography (CT) and magnetic resonance imaging (MRI) supported the diagnosis revealing the location and extension of the tumor. During the surgery, we discovered two small tumors and the histological examination revealed an embryonal type of orbital rhabdomyosarcoma. After the surgery, the patient followed an oncological treatment consisting of chemotherapy and local radiotherapy. The prognosis for life was favorable, linked with the recent diagnosis and treatment, the histological type and the good response at the oncological treatment.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"394-399"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0289-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-08DOI: 10.2478/s11536-013-0303-1
Volker Gebhardt, M. Monnard, C. Weiss, M. Schmittner
BackgroundSpinal anesthesia (SPA) and general anesthesia (GA) are both safe techniques for knee arthroscopy. In this prospective, single-centre, randomised, clinical trial we compared the discharge times of SPA using 50mg hyperbaric prilocaine 2% and GA with propofol and sufentanil in patients undergoing ambulatory knee arthroscopy.Methods50 patients (18–80 years / American Society of Anaesthesiologists grade I–III) were randomized equally to receive either SPA or GA. The main outcome variable was the time until discharge from the day-surgery centre. Anesthesia related side effects, postoperative analgesics and patient satisfaction were assessed.ResultsTwo of the spinal blocks failed and GA had to be provided. Despite of a faster recovery (unassisted ambulation: SPA: 90 (90–295)min vs. GA: 156 (93–235)min, p=0.0029), spontaneous voiding led to a delayed discharge in the SPA group (SPA: 240 (135–295)min vs. GA: 156 (93–235)min, p<0.0001). There were no differences between the groups regarding other anesthesia related side effects, postoperative demand of analgesics or patient satisfaction.ConclusionSPA with 50mg hyperbaric prilocaine 2% leads to a later discharge than GA with sufentanil and propofol. However, a reevaluation of existing discharge recommendations including obligatory micturition is necessary, to make SPA become even more advantageous for ambulatory surgery.
背景脊柱麻醉(SPA)和全身麻醉(GA)都是膝关节镜检查的安全技术。在这项前瞻性、单中心、随机的临床试验中，我们比较了在进行动态膝关节镜检查的患者中，使用50mg 2%高压丙洛卡因的SPA和使用异丙酚和舒芬太尼的GA的出院时间。方法50例患者(18-80岁/美国麻醉医师学会分级I-III级)随机分为SPA组和GA组。主要结局变量为从日间手术中心出院的时间。评估麻醉相关副作用、术后镇痛药及患者满意度。结果2例脊髓阻滞失败，需给予GA。尽管SPA组恢复更快(无辅助活动:SPA: 90 (90 - 295)min vs. GA: 156 (93-235)min, p=0.0029)，自然排尿导致SPA组延迟出院(SPA: 240 (135-295)min vs. GA: 156 (93-235)min, p<0.0001)。两组在其他麻醉相关副作用、术后镇痛药需求及患者满意度方面无差异。结论舒芬太尼和异丙酚加用高压氧丙罗卡因50mg组比加用舒芬太尼组更晚出院。然而，重新评估现有的出院建议，包括强制性排尿是必要的，使SPA对门诊手术更加有利。
{"title":"Discharge times for knee arthroscopy in spinal vs. general anesthesia","authors":"Volker Gebhardt, M. Monnard, C. Weiss, M. Schmittner","doi":"10.2478/s11536-013-0303-1","DOIUrl":"https://doi.org/10.2478/s11536-013-0303-1","url":null,"abstract":"BackgroundSpinal anesthesia (SPA) and general anesthesia (GA) are both safe techniques for knee arthroscopy. In this prospective, single-centre, randomised, clinical trial we compared the discharge times of SPA using 50mg hyperbaric prilocaine 2% and GA with propofol and sufentanil in patients undergoing ambulatory knee arthroscopy.Methods50 patients (18–80 years / American Society of Anaesthesiologists grade I–III) were randomized equally to receive either SPA or GA. The main outcome variable was the time until discharge from the day-surgery centre. Anesthesia related side effects, postoperative analgesics and patient satisfaction were assessed.ResultsTwo of the spinal blocks failed and GA had to be provided. Despite of a faster recovery (unassisted ambulation: SPA: 90 (90–295)min vs. GA: 156 (93–235)min, p=0.0029), spontaneous voiding led to a delayed discharge in the SPA group (SPA: 240 (135–295)min vs. GA: 156 (93–235)min, p<0.0001). There were no differences between the groups regarding other anesthesia related side effects, postoperative demand of analgesics or patient satisfaction.ConclusionSPA with 50mg hyperbaric prilocaine 2% leads to a later discharge than GA with sufentanil and propofol. However, a reevaluation of existing discharge recommendations including obligatory micturition is necessary, to make SPA become even more advantageous for ambulatory surgery.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"30 1","pages":"446-454"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0303-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68851251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-01DOI: 10.2478/s11536-013-0298-7
K. Vučićević, Z. Rakonjac, B. Janković, S. Vezmar Kovačević, B. Miljković, M. Prostran
Gentamicin is readily used for suspected or proven sepsis in neonates, yet it shows considerable inter-individual pharmacokinetic variability, which limits achievements of therapeutic levels. Hence, the aim of this study was to compare peak and trough gentamicin concentrations according to dosing regimen, to evaluate pharmacokinetic parameters, and to consider adjustments of dosing regimen. Babies with infection were treated with 1 h infusion, and daily dose of 5 or 7.5 mg/kg depending on the age. Patients were randomized into two groups: I — dosing interval 12 h (n=8), II — 24 h (n=11). Two steady-state blood samples were obtained. Pharmacokinetic parameters were calculated using one-compartment model. The results showed a difference (p<0.05) in peak gentamicin concentrations between the groups, and tendency of lower trough levels in the group II. Calculated pharmacokinetic parameters included the volume of distribution (Vd) 0.52±0.47 l/kg, clearance (CL) 0.055±0.036 l/hkg and a half-life (t1/2) of 6.89±3.21 h. Based on the method for dosing regimen adjustments, there was a need to extend dosing interval to 36 h in 6 patients
庆大霉素很容易用于疑似或证实的新生儿败血症，但它显示出相当大的个体间药代动力学差异，这限制了治疗水平的成就。因此，本研究的目的是根据给药方案比较庆大霉素的峰谷浓度，评价药代动力学参数，并考虑给药方案的调整。感染患儿给予1 h输液治疗，每日剂量根据年龄分别为5或7.5 mg/kg。患者随机分为两组:I -给药间隔12小时(n=8)， II - 24小时(n=11)。获得了两份稳态血液样本。采用单室模型计算药代动力学参数。结果显示，各组间庆大霉素浓度峰值有差异(p<0.05)，第二组有降低波谷的趋势。计算的药代动力学参数包括分布容积(Vd) 0.52±0.47 l/kg，清除率(CL) 0.055±0.036 l/hkg，半衰期(t1/2) 6.89±3.21 h。根据给药方案调整方法，有6例患者需要延长给药间隔至36 h
{"title":"Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates","authors":"K. Vučićević, Z. Rakonjac, B. Janković, S. Vezmar Kovačević, B. Miljković, M. Prostran","doi":"10.2478/s11536-013-0298-7","DOIUrl":"https://doi.org/10.2478/s11536-013-0298-7","url":null,"abstract":"Gentamicin is readily used for suspected or proven sepsis in neonates, yet it shows considerable inter-individual pharmacokinetic variability, which limits achievements of therapeutic levels. Hence, the aim of this study was to compare peak and trough gentamicin concentrations according to dosing regimen, to evaluate pharmacokinetic parameters, and to consider adjustments of dosing regimen. Babies with infection were treated with 1 h infusion, and daily dose of 5 or 7.5 mg/kg depending on the age. Patients were randomized into two groups: I — dosing interval 12 h (n=8), II — 24 h (n=11). Two steady-state blood samples were obtained. Pharmacokinetic parameters were calculated using one-compartment model. The results showed a difference (p<0.05) in peak gentamicin concentrations between the groups, and tendency of lower trough levels in the group II. Calculated pharmacokinetic parameters included the volume of distribution (Vd) 0.52±0.47 l/kg, clearance (CL) 0.055±0.036 l/hkg and a half-life (t1/2) of 6.89±3.21 h. Based on the method for dosing regimen adjustments, there was a need to extend dosing interval to 36 h in 6 patients","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"485-490"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0298-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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