Pub Date : 2024-02-01Epub Date: 2023-08-08DOI: 10.1007/s12070-023-04132-2
Balaji Shankarrao Mane, Rushali Madhukar Gavali
Keloid, which forms as an excessive tissue response to trauma to the skin, is a benign, hyperproliferative, recurrent growth of dermal collagen without a quiescent or regressive period throughout the process of wound healing. The aim of this study was to evaluate patient satisfaction with treatment and to compare the efficacy of intralesional injection of triamcinolone acetonide against verapamil after keloidectomy with fillet flap in auricular keloids. Our study was Duration based prospective observational study with a Duration of two years from June 2021 till May 2023 with study population inclusive of 50 patients aged between 20 and 70 years having recurrent keloid(s) over the pinna of any size or site. Keloidectomy with fillet flap and intralesional injection of trimcinolone acetonide was performed on 25 patients (30 keloids) in Group A, and keloidectomy with fillet flap and intralesional injection of verapamil was performed on 25 patients (30 keloids) in Group B. With a recurrence rate of 27%, eight keloids in Group A patients had an early recurrence three months following surgery. At nine months, nine more mixed-type cases with a 30% recurrence rate resurfaced. Recurrence seen in eight keloids out of 28 showed a 28.57% recurrence rate 12 months following surgery. Three people in Group B with three sessile keloids experienced an early recurrence at three months after surgery, with a recurrence rate of 10%. At nine months, four more cases of mixed kind returned, with a recurrence rate of 13%. A recurrence rate of 14.28% was found in 4 of 28 keloids at 12 months postoperatively. The Patient and Observer Scar Assesment Scale scores (POSAS scores) were consistently higher than Beausang scores at 1 year, indicating high patient satisfaction compared to physician assessment in both groups A and B. A keloid recurrence-free interval of 11.36 months was obtained by the Kaplan-Meier survival test (p < 0.05) in group A. Keloid recurrence-free interval of 10.98 months was evaluated by the Kaplan-Meier survival test (p < 0.05) in group B. Among Keloidectomy with fillet flap surgery with intralesional injection of triamcinolone acetonide (group A) and keloidectomy with fillet surgery with intralesional injection of verapamil (group B), at each follow-up the success rate of group B was higher than group A indicating better trend of success in this group in terms of both absence of recurrence and absence of complications without statistically significant difference between them which shown both procedures more or less similar.
{"title":"Our Experience at Tertiary Medical College-Intralesional Injection of Triamcinolone Acetonide Versus Injection Verapamil Following Keloidectomy with Fillet Flap in Auricular Keloids.","authors":"Balaji Shankarrao Mane, Rushali Madhukar Gavali","doi":"10.1007/s12070-023-04132-2","DOIUrl":"10.1007/s12070-023-04132-2","url":null,"abstract":"<p><p>Keloid, which forms as an excessive tissue response to trauma to the skin, is a benign, hyperproliferative, recurrent growth of dermal collagen without a quiescent or regressive period throughout the process of wound healing. The aim of this study was to evaluate patient satisfaction with treatment and to compare the efficacy of intralesional injection of triamcinolone acetonide against verapamil after keloidectomy with fillet flap in auricular keloids. Our study was Duration based prospective observational study with a Duration of two years from June 2021 till May 2023 with study population inclusive of 50 patients aged between 20 and 70 years having recurrent keloid(s) over the pinna of any size or site. Keloidectomy with fillet flap and intralesional injection of trimcinolone acetonide was performed on 25 patients (30 keloids) in Group A, and keloidectomy with fillet flap and intralesional injection of verapamil was performed on 25 patients (30 keloids) in Group B. With a recurrence rate of 27%, eight keloids in Group A patients had an early recurrence three months following surgery. At nine months, nine more mixed-type cases with a 30% recurrence rate resurfaced. Recurrence seen in eight keloids out of 28 showed a 28.57% recurrence rate 12 months following surgery. Three people in Group B with three sessile keloids experienced an early recurrence at three months after surgery, with a recurrence rate of 10%. At nine months, four more cases of mixed kind returned, with a recurrence rate of 13%. A recurrence rate of 14.28% was found in 4 of 28 keloids at 12 months postoperatively. The Patient and Observer Scar Assesment Scale scores (POSAS scores) were consistently higher than Beausang scores at 1 year, indicating high patient satisfaction compared to physician assessment in both groups A and B. A keloid recurrence-free interval of 11.36 months was obtained by the Kaplan-Meier survival test (<i>p</i> < 0.05) in group A. Keloid recurrence-free interval of 10.98 months was evaluated by the Kaplan-Meier survival test (<i>p</i> < 0.05) in group B. Among Keloidectomy with fillet flap surgery with intralesional injection of triamcinolone acetonide (group A) and keloidectomy with fillet surgery with intralesional injection of verapamil (group B), at each follow-up the success rate of group B was higher than group A indicating better trend of success in this group in terms of both absence of recurrence and absence of complications without statistically significant difference between them which shown both procedures more or less similar.</p>","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"3 1","pages":"237-244"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90818771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of Continuous Glucose Monitoring Systems in Patients With Type 2 Diabetes Mellitus","authors":"","doi":"10.13187/ejm.2022.1.12","DOIUrl":"https://doi.org/10.13187/ejm.2022.1.12","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75660029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulation of Transport of Ca2+ NMDA-Receptors in Rat Brain Synaptosomes Under the Influence of Polyphenols","authors":"","doi":"10.13187/ejm.2022.1.3","DOIUrl":"https://doi.org/10.13187/ejm.2022.1.3","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85694855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reasons Linked with COVID-19 Vaccine Taking and Tentativeness Amid Medical Doctors in ATBUTH Bauchi Nigeria","authors":"","doi":"10.13187/ejm.2022.1.19","DOIUrl":"https://doi.org/10.13187/ejm.2022.1.19","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87447845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors Associated with COVID-19 Vaccine Acceptance and Hesitancy amongst other Health Care Workers besides Doctors in ATBUTH Bauchi","authors":"","doi":"10.13187/ejm.2022.1.24","DOIUrl":"https://doi.org/10.13187/ejm.2022.1.24","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82555941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study focuses on the impacts of probiotics on covid-19 infection. Probiotics have the ability for enhancing gastrointestinal tract health, modulating the immune system and reducing the occurrence of allergy in susceptible people. In addition, probiotics are capable of supporting the host's immune system to fight viral infections. There is a relationship between COVID-19 disease and intestinal dysbiosis, also there are close links between gastrointestinal tract and respiratory tract infection. Probiotics can restore the composition of the gut microbiota “eubiosis”, also regulating the immune response in respiratory tract infection and acts as an anti-inflammatory that can reduce the inflammation/cytokine storm and other symptoms (vomiting, diarrhea) in COVID-19 infection. Also, strains that are related to the lactic acid bacteria (probiotic) might change the human intestine/gut microbiota through opportunistic bacteria growth suppression. Thus, stimulation and administration of the activity and growth of probiotic strains in intestine/gut might be specified as possible method for controlling food borne enteric pathogens. There were numerous health advantages to the probiotics elsewhere in the gut; the probiotics have exposed for improving the immunity, reducing severity regarding specific allergic conditions and deliberate a few anti carcinogenic characteristics.
{"title":"Probiotic Effects on Covid-19","authors":"R. Raheema, Marwa A. Al-Asady","doi":"10.13187/ejm.2021.2.28","DOIUrl":"https://doi.org/10.13187/ejm.2021.2.28","url":null,"abstract":"This study focuses on the impacts of probiotics on covid-19 infection. Probiotics have the ability for enhancing gastrointestinal tract health, modulating the immune system and reducing the occurrence of allergy in susceptible people. In addition, probiotics are capable of supporting the host's immune system to fight viral infections. There is a relationship between COVID-19 disease and intestinal dysbiosis, also there are close links between gastrointestinal tract and respiratory tract infection. Probiotics can restore the composition of the gut microbiota “eubiosis”, also regulating the immune response in respiratory tract infection and acts as an anti-inflammatory that can reduce the inflammation/cytokine storm and other symptoms (vomiting, diarrhea) in COVID-19 infection. Also, strains that are related to the lactic acid bacteria (probiotic) might change the human intestine/gut microbiota through opportunistic bacteria growth suppression. Thus, stimulation and administration of the activity and growth of probiotic strains in intestine/gut might be specified as possible method for controlling food borne enteric pathogens. There were numerous health advantages to the probiotics elsewhere in the gut; the probiotics have exposed for improving the immunity, reducing severity regarding specific allergic conditions and deliberate a few anti carcinogenic characteristics.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76213099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent Advances in Colon/Colorectal Cancer Biomarker Developments","authors":"","doi":"10.13187/ejm.2020.2.56","DOIUrl":"https://doi.org/10.13187/ejm.2020.2.56","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"42 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82855076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prejudice, Stigma and the Refusal to Offer Health Services of an Obese Pregnant Woman – An Ethical Viewpoint","authors":"","doi":"10.13187/ejm.2020.2.43","DOIUrl":"https://doi.org/10.13187/ejm.2020.2.43","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89254924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Concept of Preparing Female Students for Pregnancy Management","authors":"","doi":"10.13187/ejm.2020.2.67","DOIUrl":"https://doi.org/10.13187/ejm.2020.2.67","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83941789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Co-morbidities of Microcytic Anemia in Severe Acute Malnutrition Infants: A Tertiary Care Hospital Experience in Central India","authors":"","doi":"10.13187/ejm.2020.2.62","DOIUrl":"https://doi.org/10.13187/ejm.2020.2.62","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83474663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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