{"title":"Biomarkers of Diabetic Nephropathy Progression","authors":"","doi":"10.13187/ejm.2018.2.97","DOIUrl":"https://doi.org/10.13187/ejm.2018.2.97","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72784183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacokinetic and Pharmacodynamic Interactions of Sulfonylurea Antidiabetics","authors":"","doi":"10.13187/ejm.2018.2.83","DOIUrl":"https://doi.org/10.13187/ejm.2018.2.83","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90914282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of the Effect of Polyphenol Euphorbin on the Transport of L Glutamate and Calcium Channels to Synaptosomes of Rat Brain","authors":"","doi":"10.13187/ejm.2018.2.72","DOIUrl":"https://doi.org/10.13187/ejm.2018.2.72","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73590002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-01DOI: 10.2478/s11536-013-0322-y
P. Kutílek, V. Socha, K. Hána
Quantification of upper extremity movement is a common objective in both research and clinical practice. Currently, methods based on angle-angle diagrams, also called cyclograms, seem to be promising. Nevertheless, compared to the study of lower limbs, the concept of angle-angle diagrams has not been systematically used to study upper limb movements during walking. The paper describes two examples of new methods based on angle-angle diagrams for application in rehabilitation and assistive robotics. The cyclograms represent information about the relationship between the angles and their changes over time. We used cyclograms as patterns for learning artificial neural networks and predicting the movement of upper-limb. Together with artificial intelligence, cyclograms offer wide scope of application in prosthesis control systems. Using bilateral cyclogram, the information about the relationship between the right and left arm joint angles is used to evaluate the symmetry of movements. The method based on the orientation of the bilateral cyclogram can be used as an additional method for determining the symmetry of movements of the upper limbs or exo-prosthesis.
{"title":"Analysis and prediction of upper extremity movements by cyclograms","authors":"P. Kutílek, V. Socha, K. Hána","doi":"10.2478/s11536-013-0322-y","DOIUrl":"https://doi.org/10.2478/s11536-013-0322-y","url":null,"abstract":"Quantification of upper extremity movement is a common objective in both research and clinical practice. Currently, methods based on angle-angle diagrams, also called cyclograms, seem to be promising. Nevertheless, compared to the study of lower limbs, the concept of angle-angle diagrams has not been systematically used to study upper limb movements during walking. The paper describes two examples of new methods based on angle-angle diagrams for application in rehabilitation and assistive robotics. The cyclograms represent information about the relationship between the angles and their changes over time. We used cyclograms as patterns for learning artificial neural networks and predicting the movement of upper-limb. Together with artificial intelligence, cyclograms offer wide scope of application in prosthesis control systems. Using bilateral cyclogram, the information about the relationship between the right and left arm joint angles is used to evaluate the symmetry of movements. The method based on the orientation of the bilateral cyclogram can be used as an additional method for determining the symmetry of movements of the upper limbs or exo-prosthesis.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"814-820"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0322-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68851622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-01DOI: 10.2478/s11536-013-0324-9
C. Hoţoleanu, A. Andercou
Venous thromboembolism (VTE) causes considerable morbidity and mortality. About half of all VTE cases in adults are related to recent hospitalization, in spite of the clinical guidelines regarding prophylaxis. We aimed to assess the frequency and the independent risk factors in VTE in hospitalized patients, and to compare the risk factors in medical versus surgical cases. A case-control study consisting of 732 patients (382 with VTE and 350 controls) was designed. At least one risk factor was found in 90.31% of VTE cases; more than half of the patients presented multiple risk factors, associated with a double risk comparatively to the intervention of only one factor. A similar distribution of the risk factors was found in both medical and surgical patients, except for congestive cardiac failure (predominant in medical cases) and respectively, varicose veins, previous episode of VTE and cancer (predominant in surgical VTE patients). The independent risk factors in VTE were the following: previous episode of VTE, obesity, chronic obstructive pulmonary disease, congestive cardiac failure, varicose veins and cancer. The study shows the importance of the risk factors in VTE and the need to detect hospitalized patients at risk in both medical and surgical cases.
{"title":"Risk factors in venous thromboembolism in hospitalized patients","authors":"C. Hoţoleanu, A. Andercou","doi":"10.2478/s11536-013-0324-9","DOIUrl":"https://doi.org/10.2478/s11536-013-0324-9","url":null,"abstract":"Venous thromboembolism (VTE) causes considerable morbidity and mortality. About half of all VTE cases in adults are related to recent hospitalization, in spite of the clinical guidelines regarding prophylaxis. We aimed to assess the frequency and the independent risk factors in VTE in hospitalized patients, and to compare the risk factors in medical versus surgical cases. A case-control study consisting of 732 patients (382 with VTE and 350 controls) was designed. At least one risk factor was found in 90.31% of VTE cases; more than half of the patients presented multiple risk factors, associated with a double risk comparatively to the intervention of only one factor. A similar distribution of the risk factors was found in both medical and surgical patients, except for congestive cardiac failure (predominant in medical cases) and respectively, varicose veins, previous episode of VTE and cancer (predominant in surgical VTE patients). The independent risk factors in VTE were the following: previous episode of VTE, obesity, chronic obstructive pulmonary disease, congestive cardiac failure, varicose veins and cancer. The study shows the importance of the risk factors in VTE and the need to detect hospitalized patients at risk in both medical and surgical cases.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"729-735"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0324-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68851687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-01DOI: 10.2478/s11536-013-0310-2
A. Pietrzak, J. Mosiewicz, G. Chodorowska, A. Brzozowska, Anna Michalak-Stoma, J. Szumiło, Marcin Trojnar, D. Krasowska, B. Wawrzycki, Kinga Franciszkiewicz-Pietrzak, W. Polkowski, T. Lotti
The article focuses on the eruption of palmoplantar pustular psoriasis, which was documented in a 53-year-old man diagnosed with prostate cancer with bone metastases. This clinical finding was made during routine hormone therapy and palliative radiotherapy. The local improvement in skin lesions was achieved following administration of topical ointments and the use of UVA 311 nm radiation therapy. The management of prostate cancer in this subject resulted in malaise, onset of diabetes mellitus and increased concentration of serum lipids. Interestingly, a few days after the statin treatment was initiated, the intensive pustule eruption was observed as well as severe pain and burning sensation in the palms and soles. The dermatological treatment led to significant improvement. The patient is still receiving oncological therapy and is monitored by dermatologists on a regular basis.
{"title":"Eruption of palmoplantar pustular psoriasis in patient treated with anti-androgen therapy for prostate cancer and aggravation of lesions after statin treatment","authors":"A. Pietrzak, J. Mosiewicz, G. Chodorowska, A. Brzozowska, Anna Michalak-Stoma, J. Szumiło, Marcin Trojnar, D. Krasowska, B. Wawrzycki, Kinga Franciszkiewicz-Pietrzak, W. Polkowski, T. Lotti","doi":"10.2478/s11536-013-0310-2","DOIUrl":"https://doi.org/10.2478/s11536-013-0310-2","url":null,"abstract":"The article focuses on the eruption of palmoplantar pustular psoriasis, which was documented in a 53-year-old man diagnosed with prostate cancer with bone metastases. This clinical finding was made during routine hormone therapy and palliative radiotherapy. The local improvement in skin lesions was achieved following administration of topical ointments and the use of UVA 311 nm radiation therapy. The management of prostate cancer in this subject resulted in malaise, onset of diabetes mellitus and increased concentration of serum lipids. Interestingly, a few days after the statin treatment was initiated, the intensive pustule eruption was observed as well as severe pain and burning sensation in the palms and soles. The dermatological treatment led to significant improvement. The patient is still receiving oncological therapy and is monitored by dermatologists on a regular basis.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"657-662"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0310-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68851140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-01DOI: 10.2478/s11536-013-0329-4
F. Trofin, A. Ciobica, D. Cojocaru, M. Chirazi, C. Honceriu, Laurentiu Trofin, D. Șerban, D. Timofte, S. Cojocaru, E. Anton
Although it is accepted that an important correlation exists between the physical exercise and the oxidative stress status, the data regarding the levels of the main oxidative stress markers after physical training have been difficult to interpret and a subject of many controversies. There are also very few studies regarding the effects of short-time exercise on the oxidative stress status modifications. Thus, in the present report we were interested in studying the modifications of some oxidative stress markers (two antioxidant enzymes-superoxide dismutase and glutathione peroxidase, a lipid peroxidation parameter — malondyaldehide, the total antioxidant status and protein carbonyl levels), from the serum of rats that were subject to one bout of five minutes exercise on a treadmill, when compared to a control sedentary group. In this way, we observed a decrease of superoxide dismutase specific activity in the rats which performed the exercises. Still, no modifications of glutathione peroxidase specific activity were found between groups. In addition, increased levels of malondyaldehide and protein carbonyls were observed in the rats subjected to exercises. In conclusion, our data provides new evidence regarding the increase of the oxidative stress status, as a result of a 5-minutes bout of treadmill exercising in rats, expressed through a decrease in the SOD specific activity and the total antioxidant status and also an increase of the lipid peroxidation and protein oxidation processes.
{"title":"Increased oxidative stress status in rat serum after five minutes treadmill exercise","authors":"F. Trofin, A. Ciobica, D. Cojocaru, M. Chirazi, C. Honceriu, Laurentiu Trofin, D. Șerban, D. Timofte, S. Cojocaru, E. Anton","doi":"10.2478/s11536-013-0329-4","DOIUrl":"https://doi.org/10.2478/s11536-013-0329-4","url":null,"abstract":"Although it is accepted that an important correlation exists between the physical exercise and the oxidative stress status, the data regarding the levels of the main oxidative stress markers after physical training have been difficult to interpret and a subject of many controversies. There are also very few studies regarding the effects of short-time exercise on the oxidative stress status modifications. Thus, in the present report we were interested in studying the modifications of some oxidative stress markers (two antioxidant enzymes-superoxide dismutase and glutathione peroxidase, a lipid peroxidation parameter — malondyaldehide, the total antioxidant status and protein carbonyl levels), from the serum of rats that were subject to one bout of five minutes exercise on a treadmill, when compared to a control sedentary group. In this way, we observed a decrease of superoxide dismutase specific activity in the rats which performed the exercises. Still, no modifications of glutathione peroxidase specific activity were found between groups. In addition, increased levels of malondyaldehide and protein carbonyls were observed in the rats subjected to exercises. In conclusion, our data provides new evidence regarding the increase of the oxidative stress status, as a result of a 5-minutes bout of treadmill exercising in rats, expressed through a decrease in the SOD specific activity and the total antioxidant status and also an increase of the lipid peroxidation and protein oxidation processes.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"722-728"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0329-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68852186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-01DOI: 10.2478/s11536-013-0320-0
R. Naumovic, T. Pejčić, Ilias Cinara, J. Catalá, I. Moysset, M. Jimeno
A case of renal arteriovenous fistula between the main renal artery and interlobar vein diagnosed 25 years after percutaneous renal biopsy was presented. A 62-year-old female was referred to a urologist with dilatation of the left renal pyelocalyceal system diagnosed after abdominal ultrasonography, while intravenous urography did not confirm that finding. Historically, she underwent renal biopsy 25 years ago without any complication. Her hypertension was well controlled during the last 10 years, although three antihypertensive drugs with occasional additional diuretics were necessary during the last 6 months. Color Duplex Ultrasonography, arteriography and Multi-Slice Computed Tomography revealed the presence of renal arteriovenous fistula between the main renal artery and interlobar vein, as well as severe dilatation of all interlobar veins, renal, ovarian and adrenal vein on the left side. Urological and vascular surgeons operated to ligate the fistula and preserve the kidney. However, it was not possible to reach the fistula inside the kidney and nephrectomy was performed.
{"title":"Wide acquired arteriovenous fistula between main renal artery and interlobar vein treated with nephrectomy","authors":"R. Naumovic, T. Pejčić, Ilias Cinara, J. Catalá, I. Moysset, M. Jimeno","doi":"10.2478/s11536-013-0320-0","DOIUrl":"https://doi.org/10.2478/s11536-013-0320-0","url":null,"abstract":"A case of renal arteriovenous fistula between the main renal artery and interlobar vein diagnosed 25 years after percutaneous renal biopsy was presented. A 62-year-old female was referred to a urologist with dilatation of the left renal pyelocalyceal system diagnosed after abdominal ultrasonography, while intravenous urography did not confirm that finding. Historically, she underwent renal biopsy 25 years ago without any complication. Her hypertension was well controlled during the last 10 years, although three antihypertensive drugs with occasional additional diuretics were necessary during the last 6 months. Color Duplex Ultrasonography, arteriography and Multi-Slice Computed Tomography revealed the presence of renal arteriovenous fistula between the main renal artery and interlobar vein, as well as severe dilatation of all interlobar veins, renal, ovarian and adrenal vein on the left side. Urological and vascular surgeons operated to ligate the fistula and preserve the kidney. However, it was not possible to reach the fistula inside the kidney and nephrectomy was performed.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"676-679"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0320-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68851490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-01DOI: 10.2478/s11536-013-0327-6
Krzysztof Goryński, Izabela Safian, W. Grądzki, M. Marszałł, J. Krysiński, Sławomir Goryński, Anna Bitner, J. Romaszko, A. Buciński
Lung cancer is rated with the highest incidence and mortality every year compared with other forms of cancer, therefore early detection and diagnosis is essential. Artificial Neural Networks (ANNs) are “artificial intelligence” software which have been used to assess a few prognostic situations. In this study, a database containing 193 patients from Diagnostic and Monitoring of Tuberculosis and Illness of Lungs Ward in Kuyavia and Pomerania Centre of the Pulmonology (Bydgoszcz, Poland) was analysed using ANNs. Each patient was described using 48 factors (i.e. age, sex, data of patient history, results from medical examinations etc.) and, as an output value, the expected presence of lung cancer was established. All 48 features were retrospectively collected and the database was divided into a training set (n=97), testing set (n=48) and a validating set (n=48). The best prediction score of the ANN model (MLP 48-9-2) was above 0.99 of the area under a receiver operator characteristic (ROC) curve. The ANNs were able to correctly classify 47 out of 48 test cases. These data suggest that Artificial Neural Networks can be used in prognosis of lung cancer and could help the physician in diagnosis of patients with the suspicion of lung cancer.
{"title":"Artificial neural networks approach to early lung cancer detection","authors":"Krzysztof Goryński, Izabela Safian, W. Grądzki, M. Marszałł, J. Krysiński, Sławomir Goryński, Anna Bitner, J. Romaszko, A. Buciński","doi":"10.2478/s11536-013-0327-6","DOIUrl":"https://doi.org/10.2478/s11536-013-0327-6","url":null,"abstract":"Lung cancer is rated with the highest incidence and mortality every year compared with other forms of cancer, therefore early detection and diagnosis is essential. Artificial Neural Networks (ANNs) are “artificial intelligence” software which have been used to assess a few prognostic situations. In this study, a database containing 193 patients from Diagnostic and Monitoring of Tuberculosis and Illness of Lungs Ward in Kuyavia and Pomerania Centre of the Pulmonology (Bydgoszcz, Poland) was analysed using ANNs. Each patient was described using 48 factors (i.e. age, sex, data of patient history, results from medical examinations etc.) and, as an output value, the expected presence of lung cancer was established. All 48 features were retrospectively collected and the database was divided into a training set (n=97), testing set (n=48) and a validating set (n=48). The best prediction score of the ANN model (MLP 48-9-2) was above 0.99 of the area under a receiver operator characteristic (ROC) curve. The ANNs were able to correctly classify 47 out of 48 test cases. These data suggest that Artificial Neural Networks can be used in prognosis of lung cancer and could help the physician in diagnosis of patients with the suspicion of lung cancer.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"15 1","pages":"632-641"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0327-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68851979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-01DOI: 10.2478/s11536-013-0307-x
P. Wojtyś, A. Antczak, D. Godlewski
IntroductionThe future burden of cancer deaths will be the effect of demography changes and the influence of the risk factors. Goal. Making prognosis of number of cancer deaths in Poland in 2020.MethodologyThese predictions of number of cancer deaths in 2020 (all cancers and the most frequent cancers for men and women) has been based on the historical trends of cancer mortality in Poland in 2001–2010 and the demographical prognosis made by Central Statistical Office using the method of Hakulinen and Dyba.ResultsThere will be 58 147 cancer deaths in men and 45 970 deaths in women in 2020. Compare to the period 2006–2010 the number of cancer deaths in Poland will increase by 12.0% for men and by 13.9% for women. In 2020 the big increase in number of deaths of melanoma skin cancer and multiple myeloma for both sexes, colorectal and pancreatic cancers for men and lung, endometrial and brain cancers for women will be observed.ConclusionsThe predicted increase in number of cancer deaths for Poland in 2020 will be the results of: the demographical changes, changes of the cancer risk factors, the participation in the screening programs and treatment improvement.
{"title":"Predictions of cancer mortality in Poland in 2020","authors":"P. Wojtyś, A. Antczak, D. Godlewski","doi":"10.2478/s11536-013-0307-x","DOIUrl":"https://doi.org/10.2478/s11536-013-0307-x","url":null,"abstract":"IntroductionThe future burden of cancer deaths will be the effect of demography changes and the influence of the risk factors. Goal. Making prognosis of number of cancer deaths in Poland in 2020.MethodologyThese predictions of number of cancer deaths in 2020 (all cancers and the most frequent cancers for men and women) has been based on the historical trends of cancer mortality in Poland in 2001–2010 and the demographical prognosis made by Central Statistical Office using the method of Hakulinen and Dyba.ResultsThere will be 58 147 cancer deaths in men and 45 970 deaths in women in 2020. Compare to the period 2006–2010 the number of cancer deaths in Poland will increase by 12.0% for men and by 13.9% for women. In 2020 the big increase in number of deaths of melanoma skin cancer and multiple myeloma for both sexes, colorectal and pancreatic cancers for men and lung, endometrial and brain cancers for women will be observed.ConclusionsThe predicted increase in number of cancer deaths for Poland in 2020 will be the results of: the demographical changes, changes of the cancer risk factors, the participation in the screening programs and treatment improvement.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"667-675"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0307-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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