Pub Date : 2024-02-20DOI: 10.3390/proceedings2023091344
Duaa Altuwairki, Kirsten Brandt
{"title":"A Mini Review on the Effects of Experimental Design, Including Variations in Participant Baseline Performance, When Testing the Efficacy of Polyphenol Consumption to Enhance Mood and Cognitive Function in Humans from a New Researcher Perspective","authors":"Duaa Altuwairki, Kirsten Brandt","doi":"10.3390/proceedings2023091344","DOIUrl":"https://doi.org/10.3390/proceedings2023091344","url":null,"abstract":"","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"255 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-20DOI: 10.3390/proceedings2023091347
J. Klepacka, Marta Czarnowska-Kujawska
{"title":"An Evaluation of the Possibility of Using Buckwheat Hulls as an Addition to Bread","authors":"J. Klepacka, Marta Czarnowska-Kujawska","doi":"10.3390/proceedings2023091347","DOIUrl":"https://doi.org/10.3390/proceedings2023091347","url":null,"abstract":"","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"4 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139958246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-20DOI: 10.3390/proceedings2023091359
Sofia Tsitsou, E. Cholongitas, Triada Bali, Antonia Neonaki, K. Poulia, E. Papakonstantinou
{"title":"Effects of Time-Restricted Hypocaloric Mediterranean Diet in Patients with Non-Alcoholic Fatty Liver Disease: Preliminary Data from the CHRONO-NAFLD Project","authors":"Sofia Tsitsou, E. Cholongitas, Triada Bali, Antonia Neonaki, K. Poulia, E. Papakonstantinou","doi":"10.3390/proceedings2023091359","DOIUrl":"https://doi.org/10.3390/proceedings2023091359","url":null,"abstract":"","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"12 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139958265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-20DOI: 10.3390/proceedings2023091355
Xin Liu, Junqi Li, Jiawen Xie, Guoqing Ma, Kun Xu, Jiaomei Yang
{"title":"The Association between Body Fluid Rate with Plasma Lipid Profile, Independent of Adiposity in Young Adults","authors":"Xin Liu, Junqi Li, Jiawen Xie, Guoqing Ma, Kun Xu, Jiaomei Yang","doi":"10.3390/proceedings2023091355","DOIUrl":"https://doi.org/10.3390/proceedings2023091355","url":null,"abstract":"","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140449275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.3390/proceedings2023091338
Grace O’Donovan, Daniel Allen, Thandile Nkosi-Gondwe, Kenneth Anujuo, Mubarek Abera, Amir Kirolos, C. Opondo, L. Olga, Debbie Thompson, A. Koulman, N. Lelijveld, Amelia C. Crampin, Marko Kerac, Change Study Collaborators Group CHANGE Study Collaborators Group
: Background: Although 45 million children under five are wasted, the optimal rate of weight gain during treatment for severe malnutrition is unknown. Historically, inpatient treatment programmes focused on rapid weight gain (WG), with the rationale that this would optimise outcomes. However, recent evidence suggests that too rapid WG might be associated with higher cardiometabolic risk. Our objectives are as follows: describe WG in different programme types (e.g., inpatient, outpatient); explore any association between WG, average length of stay, and mortality/recovery; describe heterogeneity in WG reporting. Methods: For this systematic review and meta-analysis, we searched three databases: Embase (1947–2023), Global Health (1910–2023), and Medline (1946–2023), running the final search on 2nd May 2023. Papers were included if they re-ported average WG of children aged 6–59 months with severe malnutrition undergoing treatment. Non-English language and grey literature were excluded, except Emergency Nutrition Network Field Exchange articles. Summary data were extracted, and quality appraisal was done using a NICE Quality Appraisal Checklist. We conducted meta-analysis to describe pooled mean WG by programme type. We conducted meta-regression to investigate potential associations of WG with length of stay and programme outcomes. This study is registered with PROSPERO (CRD42023266472). Results: Our search yielded 3001 papers. We reviewed 307 full texts, identifying 127 eligible papers. Of these, 105 papers, with over 240,000 participants in total, reported WG as grams per kilogram per unit time and were eligible for meta-analysis. Mean rate of WG was 9.1 g/kg/d (95%CI 7.9, 10.3) across 19 inpatient programmes, and 3.9 g/kg/d (95%CI 3.5, 4.3) across 58 outpatient programmes. Faster WG was associated with shorter length of stay ( p < 0.001), but this was moderated by programme type. There was no association between WG and mortality/recovery in unadjusted analyses. There was high heterogeneity between studies. Lastly, 17% of papers did not report WG as grams per kilogram per unit time. Conclusions: Slower WG can be expected in outpatient programmes, compared to
:背景:尽管有 4500 万五岁以下儿童消瘦,但严重营养不良治疗期间的最佳体重增长速度尚不清楚。从历史上看,住院治疗计划的重点是快速增加体重(WG),理由是这样可以优化治疗效果。然而,最近的证据表明,过快的体重增加速度可能与较高的心脏代谢风险有关。我们的目标如下:描述不同项目类型(如住院病人、门诊病人)的体重增加情况;探讨体重增加、平均住院时间和死亡率/康复之间的关联;描述体重增加报告的异质性。方法:为了进行此次系统回顾和荟萃分析,我们检索了三个数据库:Embase(1947-2023 年)、Global Health(1910-2023 年)和 Medline(1946-2023 年),最终检索日期为 2023 年 5 月 2 日。凡是报道了接受治疗的 6-59 个月严重营养不良儿童平均 WG 的论文均被纳入。除紧急营养网络实地交流文章外,不包括非英语文献和灰色文献。我们提取了摘要数据,并使用 NICE 质量评估检查表进行了质量评估。我们进行了荟萃分析,以描述按项目类型划分的集合平均 WG。我们进行了元回归,以研究 WG 与住院时间和项目结果之间的潜在关联。本研究已在 PROSPERO 注册(CRD42023266472)。研究结果我们搜索到了 3001 篇论文。我们审查了 307 篇全文,确定了 127 篇符合条件的论文。其中有 105 篇论文以单位时间内每公斤克数为单位报告了 WG,符合荟萃分析的条件,这些论文的参与者总数超过 24 万人。19项住院治疗项目的平均减重率为9.1克/千克/天(95%CI为7.9-10.3),58项门诊治疗项目的平均减重率为3.9克/千克/天(95%CI为3.5-4.3)。更快的 WG 与更短的住院时间相关(p < 0.001),但这一关系因项目类型而有所缓和。在未经调整的分析中,WG与死亡率/康复率之间没有关联。不同研究之间的异质性很高。最后,17%的论文没有以单位时间内每公斤克数的形式报告 WG。结论:门诊治疗项目的 WG 值较低,而住院治疗项目的 WG 值较高。
{"title":"Weight Gain among Children with Severe Malnutrition in Therapeutic Feeding Programmes: A Systematic Review and Meta-Analysis","authors":"Grace O’Donovan, Daniel Allen, Thandile Nkosi-Gondwe, Kenneth Anujuo, Mubarek Abera, Amir Kirolos, C. Opondo, L. Olga, Debbie Thompson, A. Koulman, N. Lelijveld, Amelia C. Crampin, Marko Kerac, Change Study Collaborators Group CHANGE Study Collaborators Group","doi":"10.3390/proceedings2023091338","DOIUrl":"https://doi.org/10.3390/proceedings2023091338","url":null,"abstract":": Background: Although 45 million children under five are wasted, the optimal rate of weight gain during treatment for severe malnutrition is unknown. Historically, inpatient treatment programmes focused on rapid weight gain (WG), with the rationale that this would optimise outcomes. However, recent evidence suggests that too rapid WG might be associated with higher cardiometabolic risk. Our objectives are as follows: describe WG in different programme types (e.g., inpatient, outpatient); explore any association between WG, average length of stay, and mortality/recovery; describe heterogeneity in WG reporting. Methods: For this systematic review and meta-analysis, we searched three databases: Embase (1947–2023), Global Health (1910–2023), and Medline (1946–2023), running the final search on 2nd May 2023. Papers were included if they re-ported average WG of children aged 6–59 months with severe malnutrition undergoing treatment. Non-English language and grey literature were excluded, except Emergency Nutrition Network Field Exchange articles. Summary data were extracted, and quality appraisal was done using a NICE Quality Appraisal Checklist. We conducted meta-analysis to describe pooled mean WG by programme type. We conducted meta-regression to investigate potential associations of WG with length of stay and programme outcomes. This study is registered with PROSPERO (CRD42023266472). Results: Our search yielded 3001 papers. We reviewed 307 full texts, identifying 127 eligible papers. Of these, 105 papers, with over 240,000 participants in total, reported WG as grams per kilogram per unit time and were eligible for meta-analysis. Mean rate of WG was 9.1 g/kg/d (95%CI 7.9, 10.3) across 19 inpatient programmes, and 3.9 g/kg/d (95%CI 3.5, 4.3) across 58 outpatient programmes. Faster WG was associated with shorter length of stay ( p < 0.001), but this was moderated by programme type. There was no association between WG and mortality/recovery in unadjusted analyses. There was high heterogeneity between studies. Lastly, 17% of papers did not report WG as grams per kilogram per unit time. Conclusions: Slower WG can be expected in outpatient programmes, compared to","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"32 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140450065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.3390/proceedings2023091333
V. Vičič, Petra Pavlič, Valentina Rok, Saša Kugler, Andreja Kukec, Ruža Pandel Mikuš
Presented
介绍
{"title":"Assessment of Vitamin D Intake and Status in Slovenian Premenopausal and Postmenopausal Women","authors":"V. Vičič, Petra Pavlič, Valentina Rok, Saša Kugler, Andreja Kukec, Ruža Pandel Mikuš","doi":"10.3390/proceedings2023091333","DOIUrl":"https://doi.org/10.3390/proceedings2023091333","url":null,"abstract":"Presented","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140451655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.3390/proceedings2023091335
Cécile Gladine, N. Schebb, M. Touvier, A. Astrup, Philip Calder, A. Szuba, John W Newman
. Abstract: Eicosanoids and other oxylipins represent a superfamily of bioactive lipids involved in the regulation of crucial biological processes such as inflammation, blood clotting or endothelial reactivity. Oxylipins are generated from polyunsaturated fatty acids (PUFAs) through various enzymatic and free-radical-mediated reactions. Interestingly, each metabolic step (PUFA availability, enzyme activity and oxidative stress) can be influenced by diet. Oxylipins could therefore be important mediators of the effects of diet on human health. To provide new insights into the relationships between oxylipins, fatty acids (FAs) and diet, we conducted two independent cohort studies nested in the Polish branch of the PURE international cohort and in the French Nutrinet-Sant é cohort, respectively. The selected participants (n = 318) were healthy and fully characterized for their dietary intake. Our first objective was to determine if a healthy diet was associated with a specific oxylipin signature. Our secondary objective was to comprehensively investigate the relationships between diet, FAs and oxylipins. Participants were distributed into two groups according to the quality of their diet (based on the Alternative Healthy Eating Index (AHEI)). Targeted lipidomics was performed to comprehensively quantify plasma oxylipins and FAs. The association between oxylipins, FAs and the quality of the diet was modeled using conditional logistic regression. The relationships between oxylipins, FAs and diet were investigated using an unsupervised multiblock analysis (Multiblock Factorial Analysis (MFA)). We generated a unique database revealing unsuspected associations between diet, FAs and oxylipins. Validation studies are now required to further explore the potential of oxylipins to monitor the health effects of diet.
.摘要:二十烷酸和其他氧脂素是生物活性脂质的超家族,参与调节炎症、凝血或内皮反应性等关键生物过程。氧化脂素由多不饱和脂肪酸(PUFA)通过各种酶促和自由基介导的反应生成。有趣的是,每个代谢步骤(多不饱和脂肪酸的可用性、酶活性和氧化应激)都会受到饮食的影响。因此,氧脂素可能是饮食对人体健康影响的重要媒介。为了对氧脂素、脂肪酸和膳食之间的关系提供新的见解,我们进行了两项独立的队列研究,分别嵌套于波兰的 PURE 国际队列分支和法国的 Nutrinet-Sant é 队列。被选中的参与者(n = 318)均为健康人,其膳食摄入量具有全面特征。我们的首要目标是确定健康饮食是否与特定的氧化脂蛋白特征相关。我们的第二个目标是全面研究饮食、脂肪酸和氧脂素之间的关系。根据饮食质量(基于替代健康饮食指数(AHEI))将参与者分为两组。采用靶向脂质组学全面量化血浆中的草脂素和脂肪酸。氧脂素、脂肪酸和饮食质量之间的关系采用条件逻辑回归进行建模。利用无监督多区块分析(多区块因子分析,Multiblock Factorial Analysis (MFA))研究了氧脂素、脂肪酸和饮食之间的关系。我们建立了一个独特的数据库,揭示了膳食、脂肪酸和氧脂素之间未曾想到的关联。现在需要进行验证研究,以进一步探索氧脂素监测饮食对健康影响的潜力。
{"title":"Potential of Plasma Oxylipin Signature to Better Understand the Relationships between Diet, Fatty Acids and Oxylipins in Healthy Individuals: New Insights from Two Independent Cohort Studies","authors":"Cécile Gladine, N. Schebb, M. Touvier, A. Astrup, Philip Calder, A. Szuba, John W Newman","doi":"10.3390/proceedings2023091335","DOIUrl":"https://doi.org/10.3390/proceedings2023091335","url":null,"abstract":". Abstract: Eicosanoids and other oxylipins represent a superfamily of bioactive lipids involved in the regulation of crucial biological processes such as inflammation, blood clotting or endothelial reactivity. Oxylipins are generated from polyunsaturated fatty acids (PUFAs) through various enzymatic and free-radical-mediated reactions. Interestingly, each metabolic step (PUFA availability, enzyme activity and oxidative stress) can be influenced by diet. Oxylipins could therefore be important mediators of the effects of diet on human health. To provide new insights into the relationships between oxylipins, fatty acids (FAs) and diet, we conducted two independent cohort studies nested in the Polish branch of the PURE international cohort and in the French Nutrinet-Sant é cohort, respectively. The selected participants (n = 318) were healthy and fully characterized for their dietary intake. Our first objective was to determine if a healthy diet was associated with a specific oxylipin signature. Our secondary objective was to comprehensively investigate the relationships between diet, FAs and oxylipins. Participants were distributed into two groups according to the quality of their diet (based on the Alternative Healthy Eating Index (AHEI)). Targeted lipidomics was performed to comprehensively quantify plasma oxylipins and FAs. The association between oxylipins, FAs and the quality of the diet was modeled using conditional logistic regression. The relationships between oxylipins, FAs and diet were investigated using an unsupervised multiblock analysis (Multiblock Factorial Analysis (MFA)). We generated a unique database revealing unsuspected associations between diet, FAs and oxylipins. Validation studies are now required to further explore the potential of oxylipins to monitor the health effects of diet.","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"41 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.3390/proceedings2023091339
S. G. Duarte, Tushar More, C. M. Donado-Pestana, Rosa Maria Cerdeira Barros, Elias da Silva Araújo, Karsten Hiller, J. Fiamoncini
{"title":"Markers of Dysmetabolism Revealed Using a Dietary Challenge and Dry Blood Spots in a Remotely Executed Clinical Trial","authors":"S. G. Duarte, Tushar More, C. M. Donado-Pestana, Rosa Maria Cerdeira Barros, Elias da Silva Araújo, Karsten Hiller, J. Fiamoncini","doi":"10.3390/proceedings2023091339","DOIUrl":"https://doi.org/10.3390/proceedings2023091339","url":null,"abstract":"","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"18 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139958389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Acne is the most common skin disease in the world and reason to visit a dermatologist. It affects more than 95% of adolescents, 3% of men and 12% of adult women. Exposure to stress, fast lifestyles, hormonal imbalances, gut dysbiosis, associated diseases, and eating habits can significantly contribute to the worsening of acne. The modern concept of acne treatment is holistic
{"title":"Dietary Habits as Acne Trigger","authors":"Esma Karahmet Farhat, Ines Banjari, Tamara Jovović Sadiković","doi":"10.3390/proceedings2023091340","DOIUrl":"https://doi.org/10.3390/proceedings2023091340","url":null,"abstract":": Acne is the most common skin disease in the world and reason to visit a dermatologist. It affects more than 95% of adolescents, 3% of men and 12% of adult women. Exposure to stress, fast lifestyles, hormonal imbalances, gut dysbiosis, associated diseases, and eating habits can significantly contribute to the worsening of acne. The modern concept of acne treatment is holistic","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"141 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140451688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.3390/proceedings2023091342
Harry Stevens, Francesco Piluso, Paolo Gasparini, Y. Mavrommatis, L. Pilic, C. Graham, M. P. Concas
: Background: Sweet taste is partly modified by genetics. The rs35874116 single-nucleotide polymorphism (SNP) in taste receptor type 1 member 2 (TAS1R2) reduces the availability of a G protein-coupled receptor (GPCR), which binds to ‘sweet’ molecules. This might alter sweet taste perception, diet choices, and health outcomes. However, these findings, and other genes and pathways involved in sweet taste are yet to be identified. Therefore, a candidate gene study on TAS1R2 and a genome-wide association study (GWAS) exploring these outcomes were performed. Methods: TAS1R2 rs35874116, sweet perception, liking, diet, and health were investigated in two age-and sex-matched European cohorts (UK, n = 50/Italy, n = 235). Linear models were used to explore associations. The GWAS was performed with 2555 Italian participants. Associations with sweet food liking, food adventurousness (FA), reward dependence (RD), and health were explored. Results: The wildtype of TAS1R2 was associated with increased sweet taste and food liking ( p = 0.049, β = 0.62, p = 0.038, β = 0.45), increased fibre consumption ( p = 0.006, β = 7.95), and decreased HDL cholesterol ( p = 0.025, β = − 3.56). The GWAS identified rs58931966 in the regulator of G-protein signalling 9 (RGS9) gene. The minor allele was associated with decreased sweet food liking ( p = 7.05 × 10 – 9, β = 0.3), a higher BMI ( p = 0.007, β = 0.391), serum glucose ( p = 0.013, β = 1.211), lower FA ( p = 0.049, β = − 0.065), and RD ( p = 0.011, β = − 3.840). Discussion: The TAS1R2 results show that taste receptor variations are associated with preference, diet, and health-related outcomes. TAS1R2 not reaching significance in the GWAS shows that sweet food liking is modified by pathways besides taste reception. RSG9 is expressed in the striatum, which is involved in the mesolimbic reward pathway, which is activated by sweet taste. RGS9 rs58931966 may moderate dopaminergic signalling in response to sweet foods via the negative regulation of G-protein signalling. This might explain why the minor allele was associated with reduced RD. The lower FA might decrease preference for bitter-tasting vegetables, which could explain the higher BMI and serum glucose. The FA and RD results provide evidence that food choice depends on psychological/biological interplay. These results show that sweet taste is modified by multiple pathways and genes, and variations can modify taste, diet, and health outcomes.
{"title":"The Genetics of Sweet Taste: Perception, Feeding Behaviours, and Health","authors":"Harry Stevens, Francesco Piluso, Paolo Gasparini, Y. Mavrommatis, L. Pilic, C. Graham, M. P. Concas","doi":"10.3390/proceedings2023091342","DOIUrl":"https://doi.org/10.3390/proceedings2023091342","url":null,"abstract":": Background: Sweet taste is partly modified by genetics. The rs35874116 single-nucleotide polymorphism (SNP) in taste receptor type 1 member 2 (TAS1R2) reduces the availability of a G protein-coupled receptor (GPCR), which binds to ‘sweet’ molecules. This might alter sweet taste perception, diet choices, and health outcomes. However, these findings, and other genes and pathways involved in sweet taste are yet to be identified. Therefore, a candidate gene study on TAS1R2 and a genome-wide association study (GWAS) exploring these outcomes were performed. Methods: TAS1R2 rs35874116, sweet perception, liking, diet, and health were investigated in two age-and sex-matched European cohorts (UK, n = 50/Italy, n = 235). Linear models were used to explore associations. The GWAS was performed with 2555 Italian participants. Associations with sweet food liking, food adventurousness (FA), reward dependence (RD), and health were explored. Results: The wildtype of TAS1R2 was associated with increased sweet taste and food liking ( p = 0.049, β = 0.62, p = 0.038, β = 0.45), increased fibre consumption ( p = 0.006, β = 7.95), and decreased HDL cholesterol ( p = 0.025, β = − 3.56). The GWAS identified rs58931966 in the regulator of G-protein signalling 9 (RGS9) gene. The minor allele was associated with decreased sweet food liking ( p = 7.05 × 10 – 9, β = 0.3), a higher BMI ( p = 0.007, β = 0.391), serum glucose ( p = 0.013, β = 1.211), lower FA ( p = 0.049, β = − 0.065), and RD ( p = 0.011, β = − 3.840). Discussion: The TAS1R2 results show that taste receptor variations are associated with preference, diet, and health-related outcomes. TAS1R2 not reaching significance in the GWAS shows that sweet food liking is modified by pathways besides taste reception. RSG9 is expressed in the striatum, which is involved in the mesolimbic reward pathway, which is activated by sweet taste. RGS9 rs58931966 may moderate dopaminergic signalling in response to sweet foods via the negative regulation of G-protein signalling. This might explain why the minor allele was associated with reduced RD. The lower FA might decrease preference for bitter-tasting vegetables, which could explain the higher BMI and serum glucose. The FA and RD results provide evidence that food choice depends on psychological/biological interplay. These results show that sweet taste is modified by multiple pathways and genes, and variations can modify taste, diet, and health outcomes.","PeriodicalId":507355,"journal":{"name":"The 14th European Nutrition Conference FENS 2023","volume":"25 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140450307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}