Abdominal cystic lymphangiomas are rare entities that can manifest as retroperitoneal cystic lesions, presenting a diagnostic and therapeutic challenge. Managing these cases often requires laparotomy, laparoscopy, or percutaneous intervention, with outcomes varying in terms of success. Here, we present a case of an infected abdominal cystic lymphangioma that was successfully managed through laparoscopy, following thorough preoperative planning.
{"title":"Laparoscopic management of an adult abdominal cystic lymphangioma presenting as a retroperitoneal mass with sepsis","authors":"Ganesh Shenoy, Sanjay Natarajan","doi":"10.28982/josam.7531","DOIUrl":"https://doi.org/10.28982/josam.7531","url":null,"abstract":"Abdominal cystic lymphangiomas are rare entities that can manifest as retroperitoneal cystic lesions, presenting a diagnostic and therapeutic challenge. Managing these cases often requires laparotomy, laparoscopy, or percutaneous intervention, with outcomes varying in terms of success. Here, we present a case of an infected abdominal cystic lymphangioma that was successfully managed through laparoscopy, following thorough preoperative planning.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139808243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Şengül Şentürk, Turkan Sarioglu, Timur Köse, Y. Uyanıkgil
Background/Aim: Vitamin A is crucial for male fertility and the progression of the spermatogenetic process. Retinoic acid (RA), a metabolite of vitamin A, binds to three nuclear receptors, functioning similarly to a hormone by activating them. Our study aimed to investigate the effects of exogenous RA on spermatogenetic cell types, assessing them histochemically, immunohistochemically, and ultrastructurally. Methods: We used three groups: a control group and experimental groups treated with 40 mg/kg RA and 80 mg/kg RA. Each group contained eight adult Sprague-Dawley rats. RA, dissolved in corn oil, was administered to the experimental groups via gavage for 3 weeks. After 3 weeks, testes from the sacrificed animals were evaluated using light and electron microscopy. The sections were stained histochemically with hematoxylin-eosin (H&E) and periodic acid Schiff (PAS). Seminiferous tubules in the rats were staged using PAS staining. The cellular localization of the RARα receptor in the seminiferous tubules was identified after immunohistochemical analysis. Results: Immunoreactivity was qualitatively observed and graded from no staining to strong. In the immunohistochemical analysis, the experimental groups, particularly in stages VI, VII, VIII, and XIV, showed a significant difference in immunoreactivity compared to the control group. This difference was particularly evident in stage VI spermatogonia – the stage at which the first meiosis begins. A morphologically observed reduction in the seminiferous tubules, likely due to the loss of germ cells, was statistically significant in terms of the average diameter of the seminiferous tubules in the 80 mg/kg experimental group compared to both the control and the 40 mg/kg experimental group (P<0.001). Electron microscopic examination revealed an increase in intercellular distance, especially between basal compartment cells, in both experimental groups. Additionally, compared to the control group, both experimental groups showed an increase in the number of lipid-like granules on the membrane, particularly in the cytoplasm of spermatogonia and Sertoli cells. Conclusion: Based on our observations, this study suggests that exogenous RA can impact the overall histology of the testis. Moreover, it may play a significant role in the meiosis process by influencing the internal dynamics of spermatogenetic cell types.
背景/目的：维生素 A 对男性生育和精子生成过程的进展至关重要。维甲酸（RA）是维生素 A 的一种代谢产物，可与三种核受体结合，通过激活这些受体发挥类似激素的作用。我们的研究旨在探讨外源性RA对精子发生细胞类型的影响，通过组织化学、免疫组化和超微结构对其进行评估：我们使用了三组实验：对照组和使用 40 毫克/千克 RA 和 80 毫克/千克 RA 治疗的实验组。每组有 8 只成年 Sprague-Dawley 大鼠。通过灌胃给实验组大鼠注射溶于玉米油中的 RA，为期 3 周。3 周后，使用光镜和电子显微镜对牺牲动物的睾丸进行评估。切片用苏木精-伊红（H&E）和定期酸性希夫（PAS）进行组织化学染色。使用 PAS 染色法对大鼠的曲细精管进行分期。免疫组化分析确定了 RARα 受体在曲细精管中的细胞定位：结果：对免疫反应进行了定性观察，并从无染色到强染色进行了分级。在免疫组化分析中，实验组（尤其是 VI、VII、VIII 和 XIV 期）的免疫活性与对照组相比有显著差异。这种差异在第六期精原细胞--即第一次减数分裂开始的阶段--尤为明显。从形态学上观察到，80 毫克/千克实验组与对照组和 40 毫克/千克实验组相比，曲细精管的平均直径明显缩小（P<0.001），这可能是由于生殖细胞的损失。电子显微镜检查显示，两个实验组的细胞间距都有所增加，尤其是基底层细胞之间。此外，与对照组相比，两个实验组的细胞膜上的类脂颗粒数量都有所增加，尤其是在精原细胞和 Sertoli 细胞的细胞质中：根据我们的观察，本研究表明外源性 RA 可影响睾丸的整体组织学。结论：根据我们的观察，这项研究表明，外源性 RA 可影响睾丸的整体组织学，此外，它还可能通过影响精原细胞类型的内部动态，在减数分裂过程中发挥重要作用。
{"title":"The investigation of retinoic acid on spermatogenetic cell types of rats","authors":"Şengül Şentürk, Turkan Sarioglu, Timur Köse, Y. Uyanıkgil","doi":"10.28982/josam.7366","DOIUrl":"https://doi.org/10.28982/josam.7366","url":null,"abstract":"Background/Aim: Vitamin A is crucial for male fertility and the progression of the spermatogenetic process. Retinoic acid (RA), a metabolite of vitamin A, binds to three nuclear receptors, functioning similarly to a hormone by activating them. Our study aimed to investigate the effects of exogenous RA on spermatogenetic cell types, assessing them histochemically, immunohistochemically, and ultrastructurally.\u0000Methods: We used three groups: a control group and experimental groups treated with 40 mg/kg RA and 80 mg/kg RA. Each group contained eight adult Sprague-Dawley rats. RA, dissolved in corn oil, was administered to the experimental groups via gavage for 3 weeks. After 3 weeks, testes from the sacrificed animals were evaluated using light and electron microscopy. The sections were stained histochemically with hematoxylin-eosin (H&E) and periodic acid Schiff (PAS). Seminiferous tubules in the rats were staged using PAS staining. The cellular localization of the RARα receptor in the seminiferous tubules was identified after immunohistochemical analysis.\u0000Results: Immunoreactivity was qualitatively observed and graded from no staining to strong. In the immunohistochemical analysis, the experimental groups, particularly in stages VI, VII, VIII, and XIV, showed a significant difference in immunoreactivity compared to the control group. This difference was particularly evident in stage VI spermatogonia – the stage at which the first meiosis begins. A morphologically observed reduction in the seminiferous tubules, likely due to the loss of germ cells, was statistically significant in terms of the average diameter of the seminiferous tubules in the 80 mg/kg experimental group compared to both the control and the 40 mg/kg experimental group (P<0.001). Electron microscopic examination revealed an increase in intercellular distance, especially between basal compartment cells, in both experimental groups. Additionally, compared to the control group, both experimental groups showed an increase in the number of lipid-like granules on the membrane, particularly in the cytoplasm of spermatogonia and Sertoli cells.\u0000Conclusion: Based on our observations, this study suggests that exogenous RA can impact the overall histology of the testis. Moreover, it may play a significant role in the meiosis process by influencing the internal dynamics of spermatogenetic cell types.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"47 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Şengül Şentürk, Turkan Sarioglu, Timur Köse, Y. Uyanıkgil
Background/Aim: Vitamin A is crucial for male fertility and the progression of the spermatogenetic process. Retinoic acid (RA), a metabolite of vitamin A, binds to three nuclear receptors, functioning similarly to a hormone by activating them. Our study aimed to investigate the effects of exogenous RA on spermatogenetic cell types, assessing them histochemically, immunohistochemically, and ultrastructurally. Methods: We used three groups: a control group and experimental groups treated with 40 mg/kg RA and 80 mg/kg RA. Each group contained eight adult Sprague-Dawley rats. RA, dissolved in corn oil, was administered to the experimental groups via gavage for 3 weeks. After 3 weeks, testes from the sacrificed animals were evaluated using light and electron microscopy. The sections were stained histochemically with hematoxylin-eosin (H&E) and periodic acid Schiff (PAS). Seminiferous tubules in the rats were staged using PAS staining. The cellular localization of the RARα receptor in the seminiferous tubules was identified after immunohistochemical analysis. Results: Immunoreactivity was qualitatively observed and graded from no staining to strong. In the immunohistochemical analysis, the experimental groups, particularly in stages VI, VII, VIII, and XIV, showed a significant difference in immunoreactivity compared to the control group. This difference was particularly evident in stage VI spermatogonia – the stage at which the first meiosis begins. A morphologically observed reduction in the seminiferous tubules, likely due to the loss of germ cells, was statistically significant in terms of the average diameter of the seminiferous tubules in the 80 mg/kg experimental group compared to both the control and the 40 mg/kg experimental group (P<0.001). Electron microscopic examination revealed an increase in intercellular distance, especially between basal compartment cells, in both experimental groups. Additionally, compared to the control group, both experimental groups showed an increase in the number of lipid-like granules on the membrane, particularly in the cytoplasm of spermatogonia and Sertoli cells. Conclusion: Based on our observations, this study suggests that exogenous RA can impact the overall histology of the testis. Moreover, it may play a significant role in the meiosis process by influencing the internal dynamics of spermatogenetic cell types.
背景/目的：维生素 A 对男性生育和精子生成过程的进展至关重要。维甲酸（RA）是维生素 A 的一种代谢产物，可与三种核受体结合，通过激活这些受体发挥类似激素的作用。我们的研究旨在探讨外源性RA对精子发生细胞类型的影响，通过组织化学、免疫组化和超微结构对其进行评估：我们使用了三组实验：对照组和使用 40 毫克/千克 RA 和 80 毫克/千克 RA 治疗的实验组。每组有 8 只成年 Sprague-Dawley 大鼠。通过灌胃给实验组大鼠注射溶于玉米油中的 RA，为期 3 周。3 周后，使用光镜和电子显微镜对牺牲动物的睾丸进行评估。切片用苏木精-伊红（H&E）和定期酸性希夫（PAS）进行组织化学染色。使用 PAS 染色法对大鼠的曲细精管进行分期。免疫组化分析确定了 RARα 受体在曲细精管中的细胞定位：结果：对免疫反应进行了定性观察，并从无染色到强染色进行了分级。在免疫组化分析中，实验组（尤其是 VI、VII、VIII 和 XIV 期）的免疫活性与对照组相比有显著差异。这种差异在第六期精原细胞--即第一次减数分裂开始的阶段--尤为明显。从形态学上观察到，80 毫克/千克实验组与对照组和 40 毫克/千克实验组相比，曲细精管的平均直径明显缩小（P<0.001），这可能是由于生殖细胞的损失。电子显微镜检查显示，两个实验组的细胞间距都有所增加，尤其是基底层细胞之间。此外，与对照组相比，两个实验组的细胞膜上的类脂颗粒数量都有所增加，尤其是在精原细胞和 Sertoli 细胞的细胞质中：根据我们的观察，本研究表明外源性 RA 可影响睾丸的整体组织学。结论：根据我们的观察，这项研究表明，外源性 RA 可影响睾丸的整体组织学，此外，它还可能通过影响精原细胞类型的内部动态，在减数分裂过程中发挥重要作用。
{"title":"The investigation of retinoic acid on spermatogenetic cell types of rats","authors":"Şengül Şentürk, Turkan Sarioglu, Timur Köse, Y. Uyanıkgil","doi":"10.28982/josam.7366","DOIUrl":"https://doi.org/10.28982/josam.7366","url":null,"abstract":"Background/Aim: Vitamin A is crucial for male fertility and the progression of the spermatogenetic process. Retinoic acid (RA), a metabolite of vitamin A, binds to three nuclear receptors, functioning similarly to a hormone by activating them. Our study aimed to investigate the effects of exogenous RA on spermatogenetic cell types, assessing them histochemically, immunohistochemically, and ultrastructurally.\u0000Methods: We used three groups: a control group and experimental groups treated with 40 mg/kg RA and 80 mg/kg RA. Each group contained eight adult Sprague-Dawley rats. RA, dissolved in corn oil, was administered to the experimental groups via gavage for 3 weeks. After 3 weeks, testes from the sacrificed animals were evaluated using light and electron microscopy. The sections were stained histochemically with hematoxylin-eosin (H&E) and periodic acid Schiff (PAS). Seminiferous tubules in the rats were staged using PAS staining. The cellular localization of the RARα receptor in the seminiferous tubules was identified after immunohistochemical analysis.\u0000Results: Immunoreactivity was qualitatively observed and graded from no staining to strong. In the immunohistochemical analysis, the experimental groups, particularly in stages VI, VII, VIII, and XIV, showed a significant difference in immunoreactivity compared to the control group. This difference was particularly evident in stage VI spermatogonia – the stage at which the first meiosis begins. A morphologically observed reduction in the seminiferous tubules, likely due to the loss of germ cells, was statistically significant in terms of the average diameter of the seminiferous tubules in the 80 mg/kg experimental group compared to both the control and the 40 mg/kg experimental group (P<0.001). Electron microscopic examination revealed an increase in intercellular distance, especially between basal compartment cells, in both experimental groups. Additionally, compared to the control group, both experimental groups showed an increase in the number of lipid-like granules on the membrane, particularly in the cytoplasm of spermatogonia and Sertoli cells.\u0000Conclusion: Based on our observations, this study suggests that exogenous RA can impact the overall histology of the testis. Moreover, it may play a significant role in the meiosis process by influencing the internal dynamics of spermatogenetic cell types.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"121 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139810094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osman Ergün, T. A. Serel, Sefa Alperen Öztürk, Huseyin Bulut Serel, S. Soyupek, B. Hoşcan
Background/Aim: Vesicoureteral reflux (VUR) is a condition that causes urine to flow in reverse, from the bladder back into the ureters and occasionally into the kidneys. It becomes a vital cause of urinary tract infections. Conventionally, VUR’s severity is evaluated through imaging via voiding cystourethrography (VCUG). However, there is an unresolved debate regarding the precise timing and type of surgery required, making it crucial to classify VUR grades uniformly and accurately. This study’s primary purpose is to leverage machine learning, particularly convolutional neural network (CNN), to effectively identify and classify VUR in VCUG images. The aspiration is to diminish classification discrepancies between different observers and to create an accessible tool for healthcare practitioners. Methods: We utilized a dataset of 59 VCUG images with diagnosed VUR sourced from OpenI. These images were independently classified by two seasoned urologists according to the International Reflux Classification System. We utilized TensorFlow, Keras, and Jupyter Notebook for data preparation, segmentation, and model building. The CNN Inception V3 was employed for transfer learning, while data augmentation was used to improve the model’s resilience. Results: The deep-learning model attained exceptional accuracy rates of 95% and 100% in validation and training, respectively, after six cycles. It effectively categorized VUR grades corresponding to the global classification system. Matplotlib tracked loss and accuracy values, while Python-based statistical analysis assessed the model’s performance using the F1-score. Conclusion: The study’s model effectively categorized images, including those of vesicoureteral reflux, which has significant implications for treatment decisions. The application of this artificial intelligence model may help reduce interobserver bias. Additionally, it could offer an objective method for surgical planning and treatment outcomes.
{"title":"Deep-learning-based diagnosis and grading of vesicoureteral reflux: A novel approach for improved clinical decision-making","authors":"Osman Ergün, T. A. Serel, Sefa Alperen Öztürk, Huseyin Bulut Serel, S. Soyupek, B. Hoşcan","doi":"10.28982/josam.8020","DOIUrl":"https://doi.org/10.28982/josam.8020","url":null,"abstract":"Background/Aim: Vesicoureteral reflux (VUR) is a condition that causes urine to flow in reverse, from the bladder back into the ureters and occasionally into the kidneys. It becomes a vital cause of urinary tract infections. Conventionally, VUR’s severity is evaluated through imaging via voiding cystourethrography (VCUG). However, there is an unresolved debate regarding the precise timing and type of surgery required, making it crucial to classify VUR grades uniformly and accurately. This study’s primary purpose is to leverage machine learning, particularly convolutional neural network (CNN), to effectively identify and classify VUR in VCUG images. The aspiration is to diminish classification discrepancies between different observers and to create an accessible tool for healthcare practitioners.\u0000Methods: We utilized a dataset of 59 VCUG images with diagnosed VUR sourced from OpenI. These images were independently classified by two seasoned urologists according to the International Reflux Classification System. We utilized TensorFlow, Keras, and Jupyter Notebook for data preparation, segmentation, and model building. The CNN Inception V3 was employed for transfer learning, while data augmentation was used to improve the model’s resilience.\u0000Results: The deep-learning model attained exceptional accuracy rates of 95% and 100% in validation and training, respectively, after six cycles. It effectively categorized VUR grades corresponding to the global classification system. Matplotlib tracked loss and accuracy values, while Python-based statistical analysis assessed the model’s performance using the F1-score.\u0000Conclusion: The study’s model effectively categorized images, including those of vesicoureteral reflux, which has significant implications for treatment decisions. The application of this artificial intelligence model may help reduce interobserver bias. Additionally, it could offer an objective method for surgical planning and treatment outcomes.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":" 697","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: Restless legs syndrome (RLS) is a chronic neurological disease that impairs sleep quality, causes emotional stress and affects daily activities. While the association between disease severity and low iron and ferritin levels is known, the magnesium (Mg) results are contradictory. This study aimed to investigate the influence of low Mg and ferritin levels on the severity of the disease and sleep quality. Methods: A case-control study included 50 RLS patients aged 18–78 years and 50 healthy control patients. Mg and ferritin levels were measured, considering values below <1.8 mg/dL and 75 ng/mL as low. Both groups completed the International Restless Legs Syndrome Severity Rating Scale (IRLSSG) to assess the severity of RLS, as well as the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) to evaluate subjective sleep quality. Results: The mean age of RLS patients and the control group was 47.06 (13.35) years and 43.30 (15.43) years, respectively (P=0.196). The RLS patients had an IRLSSG score of 25.16 (6.85). The PSQI total scores, subscale scores, and ESS scores of RLS patients were significantly higher than those of the control group. However, no significant difference was observed in the IRLSSG score, PSQI, and ESS scores based on Mg and ferritin levels. Sleep latency was found to be shorter in individuals with Mg deficiency. Conclusion: Sleep disorders are prevalent among RLS patients. No correlation was found between Mg and ferritin levels and disease severity or sleep disorders. Furthermore, Mg deficiency did not appear to exacerbate the IRLSSG score or sleep disorder scores.
{"title":"A study of the correlation between magnesium and ferritin levels and the severity of the disease and sleep quality in restless legs syndrome","authors":"Sibel Üstün Özek","doi":"10.28982/josam.7511","DOIUrl":"https://doi.org/10.28982/josam.7511","url":null,"abstract":"Background/Aim: Restless legs syndrome (RLS) is a chronic neurological disease that impairs sleep quality, causes emotional stress and affects daily activities. While the association between disease severity and low iron and ferritin levels is known, the magnesium (Mg) results are contradictory. This study aimed to investigate the influence of low Mg and ferritin levels on the severity of the disease and sleep quality.\u0000Methods: A case-control study included 50 RLS patients aged 18–78 years and 50 healthy control patients. Mg and ferritin levels were measured, considering values below <1.8 mg/dL and 75 ng/mL as low. Both groups completed the International Restless Legs Syndrome Severity Rating Scale (IRLSSG) to assess the severity of RLS, as well as the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) to evaluate subjective sleep quality.\u0000Results: The mean age of RLS patients and the control group was 47.06 (13.35) years and 43.30 (15.43) years, respectively (P=0.196). The RLS patients had an IRLSSG score of 25.16 (6.85). The PSQI total scores, subscale scores, and ESS scores of RLS patients were significantly higher than those of the control group. However, no significant difference was observed in the IRLSSG score, PSQI, and ESS scores based on Mg and ferritin levels. Sleep latency was found to be shorter in individuals with Mg deficiency.\u0000Conclusion: Sleep disorders are prevalent among RLS patients. No correlation was found between Mg and ferritin levels and disease severity or sleep disorders. Furthermore, Mg deficiency did not appear to exacerbate the IRLSSG score or sleep disorder scores.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"62 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuropathic arthropathy is a chronic degenerative arthropathy that results from a neurosensory deficit of the affected joint. According to neurovascular theory, the loss of sensation of the joint is responsible for its formation. Chronic inflammatory demyelination polyneuropathy (CIDP) is a rare disease with sensorimotor involvement in which demyelination and axonal damage occur in the peripheral nerves as a result of an abnormal immune response. A case is presented of a 64-year-old male patient with a diagnosis of CIDP who had Charcot arthropathy of the right shoulder.
{"title":"Neuropathic arthropathy of the shoulder associated with chronic inflammatory demyelinating polyneuropathy: A case report","authors":"Burcu Ortanca, O. Armağan, Mazlum Doğan Bilici","doi":"10.28982/josam.7451","DOIUrl":"https://doi.org/10.28982/josam.7451","url":null,"abstract":"Neuropathic arthropathy is a chronic degenerative arthropathy that results from a neurosensory deficit of the affected joint. According to neurovascular theory, the loss of sensation of the joint is responsible for its formation. Chronic inflammatory demyelination polyneuropathy (CIDP) is a rare disease with sensorimotor involvement in which demyelination and axonal damage occur in the peripheral nerves as a result of an abnormal immune response. A case is presented of a 64-year-old male patient with a diagnosis of CIDP who had Charcot arthropathy of the right shoulder.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"298 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: Although stressors and traumatic life events are known to be predisposing factors for developing functional neurological disorder (FND), the etiology of the disorder has not been fully elucidated. In this study, oxidative stress parameters and serum levels of S100B protein were investigated in pediatric patients with functional neurological disorder. The association of these parameters with stress factors and traumatic life events was investigated. Methods: This case-control study included a control group of 35 patients aged 8-18 years and 32 healthy subjects diagnosed with functional neurological disorder. The Childhood Trauma Scale and Dissociative Experiences Scale were applied to both groups. Serum levels of the patient and control groups were compared by blood sampling: total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and S100B. Results: It was found that the Childhood Trauma Scale total score, emotional neglect, emotional abuse, physical neglect and the Dissociative Experiences Scale were statistically significantly higher in the FND group than in the control group (P˂0.001, P˂0.001, P=0.013, P=0.017, P˂0.001). Stressors were found to be statistically significantly higher in the FND group than in the control group (P=0.020). There was no statistical difference between the FND group and control groups regarding the TAS, TOS, OSI, and S100B levels (P=0.965, P=0.228, P=0.268, P=0.517, respectively). Conclusion: Our study is the first to investigate TOS, TAS, OSI and S100B in children with FND. In our study, although stressors and traumatic experiences were significantly higher in the functional neurological disorder group compared to the control group according to the stress susceptibility model, contrary to expectations, there was no significant difference in oxidative stress parameters and serum S100B levels. It was thought that the interaction between FND, which is characterized by biopsychosocial interaction and can manifest itself with various clinical symptoms, and stress may not be linear as initially thought, and the interaction between genetic predisposition and environmental factors may play a more complex role. The absence of significant differences observed in oxidative stress parameters and serum S100B levels may suggest that we should focus on different pathways and different potential biomarkers that need to be investigated in the future to understand the etiology and diagnosis of FND. However, the limitations noted above may affect the generalizability of the study findings.
{"title":"The role of oxidative stress levels and S100B levels in children with functional neurological disorder","authors":"E. Sizer, Tuğba Çobanoğlu, İbrahim Kaplan","doi":"10.28982/josam.7856","DOIUrl":"https://doi.org/10.28982/josam.7856","url":null,"abstract":"Background/Aim: Although stressors and traumatic life events are known to be predisposing factors for developing functional neurological disorder (FND), the etiology of the disorder has not been fully elucidated. In this study, oxidative stress parameters and serum levels of S100B protein were investigated in pediatric patients with functional neurological disorder. The association of these parameters with stress factors and traumatic life events was investigated. Methods: This case-control study included a control group of 35 patients aged 8-18 years and 32 healthy subjects diagnosed with functional neurological disorder. The Childhood Trauma Scale and Dissociative Experiences Scale were applied to both groups. Serum levels of the patient and control groups were compared by blood sampling: total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and S100B. Results: It was found that the Childhood Trauma Scale total score, emotional neglect, emotional abuse, physical neglect and the Dissociative Experiences Scale were statistically significantly higher in the FND group than in the control group (P˂0.001, P˂0.001, P=0.013, P=0.017, P˂0.001). Stressors were found to be statistically significantly higher in the FND group than in the control group (P=0.020). There was no statistical difference between the FND group and control groups regarding the TAS, TOS, OSI, and S100B levels (P=0.965, P=0.228, P=0.268, P=0.517, respectively). Conclusion: Our study is the first to investigate TOS, TAS, OSI and S100B in children with FND. In our study, although stressors and traumatic experiences were significantly higher in the functional neurological disorder group compared to the control group according to the stress susceptibility model, contrary to expectations, there was no significant difference in oxidative stress parameters and serum S100B levels. It was thought that the interaction between FND, which is characterized by biopsychosocial interaction and can manifest itself with various clinical symptoms, and stress may not be linear as initially thought, and the interaction between genetic predisposition and environmental factors may play a more complex role. The absence of significant differences observed in oxidative stress parameters and serum S100B levels may suggest that we should focus on different pathways and different potential biomarkers that need to be investigated in the future to understand the etiology and diagnosis of FND. However, the limitations noted above may affect the generalizability of the study findings.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"39 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139185678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sefa Kurt, S. Ozmen, O. Yavuz, Orkun Ilgen, E. Ulukus
Background/Aim: Breast cancer is the leading cause of cancer-related fatalities in women. Tamoxifen, a selective estrogen receptor modulator (SERM), is frequently employed for chemoprevention in hormone receptor (HR)-positive breast cancer patients due to its anti-estrogenic impact on breast tissue. Nevertheless, tamoxifen exhibits agonistic effects on the endometrium, particularly in postmenopausal women. This study aims to assess gynecological issues and endometrial pathologies that emerge during the treatment and follow-up phases of women diagnosed with HR-positive/negative breast cancer. Methods: This cohort study involved a data review from 857 breast cancer patients diagnosed over a decade at a tertiary center. Histopathological endometrial findings were evaluated for 166 patients who underwent gynecological consultations before breast cancer treatment with normal examination results and underwent invasive assessments due to gynecological symptoms that arose during treatment and follow-up. The study encompassed cases culminating in total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO). Results: The study analyzed 166 cases meeting the inclusion criteria. The mean age at breast cancer diagnosis was 48 years with a standard deviation of 8.4 years, and the average follow-up duration was 4.1 (3.8) years. The predominant histopathological type was invasive ductal carcinoma (75.3%). Of the cases, 68.6% occurred during premenopausal and 31.4% during postmenopause. HR positivity was identified in 136 cases (81.9%), while 30 (18.1%) exhibited negative HR status. Among HR-positive cases, 113 (83.0%) received tamoxifen treatment, while 23 (17.0%) were treated with letrozole. Common clinical findings during and after treatment encompassed increased endometrial thickness (ET) and abnormal uterine bleeding (AUB). Histopathological evaluation of invasive procedures prompted by increased ET indicated the following frequent endometrial findings: proliferative endometrium (33.1%), endometrial polyp (20.5%), and endometrial hyperplasia (EH) without atypia (9%). The histopathological outcomes of invasive procedures prompted by AUB included atrophic endometrium (11.4%), proliferative endometrium (3.6%), and endometrial cancer (1.8%). Among the endometrial malignancies, three occurred in the premenopausal phase and four in the postmenopausal phase. Notably, three of the seven endometrial malignancies were observed in the tamoxifen hormone therapy group, all HR-positive. Four cases were from the non-tamoxifen hormone therapy group with negative HR status. Conclusion: Globally, breast cancer ranks as the most prevalent malignancy in women. Tamoxifen, a frequently utilized adjuvant therapy post breast cancer surgery, can exert diverse effects on gynecological organs, encompassing benign pathologies like increased ET and malignant pathologies like uterine neoplasia. There is a rising suspicion that etiopathogenetic factors contributing to breast
{"title":"Endometrial pathologies in clinical follow-up of patients with hormone receptor-positive/negative breast cancer","authors":"Sefa Kurt, S. Ozmen, O. Yavuz, Orkun Ilgen, E. Ulukus","doi":"10.28982/josam.7583","DOIUrl":"https://doi.org/10.28982/josam.7583","url":null,"abstract":"Background/Aim: Breast cancer is the leading cause of cancer-related fatalities in women. Tamoxifen, a selective estrogen receptor modulator (SERM), is frequently employed for chemoprevention in hormone receptor (HR)-positive breast cancer patients due to its anti-estrogenic impact on breast tissue. Nevertheless, tamoxifen exhibits agonistic effects on the endometrium, particularly in postmenopausal women. This study aims to assess gynecological issues and endometrial pathologies that emerge during the treatment and follow-up phases of women diagnosed with HR-positive/negative breast cancer. Methods: This cohort study involved a data review from 857 breast cancer patients diagnosed over a decade at a tertiary center. Histopathological endometrial findings were evaluated for 166 patients who underwent gynecological consultations before breast cancer treatment with normal examination results and underwent invasive assessments due to gynecological symptoms that arose during treatment and follow-up. The study encompassed cases culminating in total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO). Results: The study analyzed 166 cases meeting the inclusion criteria. The mean age at breast cancer diagnosis was 48 years with a standard deviation of 8.4 years, and the average follow-up duration was 4.1 (3.8) years. The predominant histopathological type was invasive ductal carcinoma (75.3%). Of the cases, 68.6% occurred during premenopausal and 31.4% during postmenopause. HR positivity was identified in 136 cases (81.9%), while 30 (18.1%) exhibited negative HR status. Among HR-positive cases, 113 (83.0%) received tamoxifen treatment, while 23 (17.0%) were treated with letrozole. Common clinical findings during and after treatment encompassed increased endometrial thickness (ET) and abnormal uterine bleeding (AUB). Histopathological evaluation of invasive procedures prompted by increased ET indicated the following frequent endometrial findings: proliferative endometrium (33.1%), endometrial polyp (20.5%), and endometrial hyperplasia (EH) without atypia (9%). The histopathological outcomes of invasive procedures prompted by AUB included atrophic endometrium (11.4%), proliferative endometrium (3.6%), and endometrial cancer (1.8%). Among the endometrial malignancies, three occurred in the premenopausal phase and four in the postmenopausal phase. Notably, three of the seven endometrial malignancies were observed in the tamoxifen hormone therapy group, all HR-positive. Four cases were from the non-tamoxifen hormone therapy group with negative HR status. Conclusion: Globally, breast cancer ranks as the most prevalent malignancy in women. Tamoxifen, a frequently utilized adjuvant therapy post breast cancer surgery, can exert diverse effects on gynecological organs, encompassing benign pathologies like increased ET and malignant pathologies like uterine neoplasia. There is a rising suspicion that etiopathogenetic factors contributing to breast","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"57 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139185890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yigit Kultur, Sinan Karaca, Mehmet Nuri Erdem, E. Şahin, Elviz Gasimov, M. Biscevic, Mehmet Tezer
Background/Aim: Most scoring systems in healthcare take into account the physical condition and pain status of a patient, but the impact of society on the individual is ignored. The aim of our study was to evaluate the social media posts made by patients regarding lumbar discectomy surgery. The objective was to identify and explore concerns and issues that may not be immediately evident during clinical evaluations but are significant to the patients themselves. Methods: Public posts with the hashtags #discectomy, #lumbardisectomy, and #discectomyrecovery were examined on the Instagram application. The tone of the post, return to sports (RTS), rehabilitation or physical therapy (PT), return to work (RTW), incision site (e.g., scarring, sutures, and dressing), pain, activities of daily living (ADL), and X-ray/magnetic resonance imaging (MRI) data were evaluated. The "Instagram likes ratio" was determined by dividing the total number of likes received for each post by the number of followers. Results: 272 posts were assessed, and 77.9% of them exhibited a positive tone. The topic that was most frequently discussed was ADL, which was discussed in 24.6% of the posts. Statistical analysis demonstrated a significant association between positive tone and ADL, as well as positive tone and RTS (P<0.001). A statistically significant correlation was observed between negative tone and neurological deficits, pain, and X-ray/MRI findings (P<0.001). Conclusion: Our study offers a unique perspective on the experience and satisfaction of patients who have undergone lumbar discectomy. Neurologic deficits and pain were notably significant in the negative posts. However, in general, the majority of the posts maintained a positive tone. The results could provide insights into patients' experiences and perspectives that can potentially inform healthcare professionals in providing more comprehensive and patient-centered care.
{"title":"Instagram and lumbar discectomy surgery: An evaluation of patients’ perception of surgery in social media","authors":"Yigit Kultur, Sinan Karaca, Mehmet Nuri Erdem, E. Şahin, Elviz Gasimov, M. Biscevic, Mehmet Tezer","doi":"10.28982/josam.7452","DOIUrl":"https://doi.org/10.28982/josam.7452","url":null,"abstract":"Background/Aim: Most scoring systems in healthcare take into account the physical condition and pain status of a patient, but the impact of society on the individual is ignored. The aim of our study was to evaluate the social media posts made by patients regarding lumbar discectomy surgery. The objective was to identify and explore concerns and issues that may not be immediately evident during clinical evaluations but are significant to the patients themselves. Methods: Public posts with the hashtags #discectomy, #lumbardisectomy, and #discectomyrecovery were examined on the Instagram application. The tone of the post, return to sports (RTS), rehabilitation or physical therapy (PT), return to work (RTW), incision site (e.g., scarring, sutures, and dressing), pain, activities of daily living (ADL), and X-ray/magnetic resonance imaging (MRI) data were evaluated. The \"Instagram likes ratio\" was determined by dividing the total number of likes received for each post by the number of followers. Results: 272 posts were assessed, and 77.9% of them exhibited a positive tone. The topic that was most frequently discussed was ADL, which was discussed in 24.6% of the posts. Statistical analysis demonstrated a significant association between positive tone and ADL, as well as positive tone and RTS (P<0.001). A statistically significant correlation was observed between negative tone and neurological deficits, pain, and X-ray/MRI findings (P<0.001). Conclusion: Our study offers a unique perspective on the experience and satisfaction of patients who have undergone lumbar discectomy. Neurologic deficits and pain were notably significant in the negative posts. However, in general, the majority of the posts maintained a positive tone. The results could provide insights into patients' experiences and perspectives that can potentially inform healthcare professionals in providing more comprehensive and patient-centered care.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139186456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Konan Marc Koffi, Ory Opokou Alexandre De Misères, Boka Koffi Laurent, Yapo Aké Lucien Jonathan, Asseke Assoumou Lucien, Harding Mouan Béatrice, Ouattara Bakary, Ettien Béatrice
Background/Aim: Centrofacial fractures resulting from high-impact violence can be considered mild traumatic brain injuries. Given the complexities and associated risks, a comprehensive examination of these fractures is warranted. These fractures are increasingly prevalent among young adult patients and are commonly associated with road traffic accidents. In the literature, only a few studies have focused on this particular type of facial bone lesion. In Ivory Coast, no studies have been conducted on these fractures, which highlights the importance of our research aimed at describing the epidemiological and anatomical-clinical characteristics of centrofacial fractures in the stomatology and maxillofacial surgery department of the Cocody Teaching Hospital. Methods: This descriptive cross-sectional study was conducted in the Stomatology and Maxillofacial Surgery Department of the Cocody University Hospital Center from January 2016 to December 2020. Results: The prevalence of these fractures was 24.20%, with a predominance of male subjects. The age group most affected was 20 to 40 years old, accounting for 70.96% of cases, and most patients resided in Abidjan (59%). All socio-economic categories were represented, with a higher proportion of individuals in liberal professions (91.4%). Road traffic accidents involving two-wheeled vehicles were the primary cause of these fractures (76.8%), with the most common injury site being the naso-ethmoido-maxillo-fronto-orbital complex (NEMFOC) (32.5%). Conclusion: The epidemiological characteristics of centrofacial fractures associated with two-wheeled vehicles in the Abidjan metropolis of Côte d'Ivoire suggest the need for increased accountability among motor vehicle drivers and stricter enforcement of traffic laws.
{"title":"Cross-sectional and descriptive study of centrofacial fractures at the Cocody University Hospital Center from 2016 to 2020","authors":"Konan Marc Koffi, Ory Opokou Alexandre De Misères, Boka Koffi Laurent, Yapo Aké Lucien Jonathan, Asseke Assoumou Lucien, Harding Mouan Béatrice, Ouattara Bakary, Ettien Béatrice","doi":"10.28982/josam.7289","DOIUrl":"https://doi.org/10.28982/josam.7289","url":null,"abstract":"Background/Aim: Centrofacial fractures resulting from high-impact violence can be considered mild traumatic brain injuries. Given the complexities and associated risks, a comprehensive examination of these fractures is warranted. These fractures are increasingly prevalent among young adult patients and are commonly associated with road traffic accidents. In the literature, only a few studies have focused on this particular type of facial bone lesion. In Ivory Coast, no studies have been conducted on these fractures, which highlights the importance of our research aimed at describing the epidemiological and anatomical-clinical characteristics of centrofacial fractures in the stomatology and maxillofacial surgery department of the Cocody Teaching Hospital. Methods: This descriptive cross-sectional study was conducted in the Stomatology and Maxillofacial Surgery Department of the Cocody University Hospital Center from January 2016 to December 2020. Results: The prevalence of these fractures was 24.20%, with a predominance of male subjects. The age group most affected was 20 to 40 years old, accounting for 70.96% of cases, and most patients resided in Abidjan (59%). All socio-economic categories were represented, with a higher proportion of individuals in liberal professions (91.4%). Road traffic accidents involving two-wheeled vehicles were the primary cause of these fractures (76.8%), with the most common injury site being the naso-ethmoido-maxillo-fronto-orbital complex (NEMFOC) (32.5%). Conclusion: The epidemiological characteristics of centrofacial fractures associated with two-wheeled vehicles in the Abidjan metropolis of Côte d'Ivoire suggest the need for increased accountability among motor vehicle drivers and stricter enforcement of traffic laws.","PeriodicalId":508175,"journal":{"name":"Journal of Surgery and Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139233081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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