Eine Rituximab-Therapie wirkt sich bei Patienten mit rheumatischen und muskuloskelettalen Erkrankungen mit einer verringerten humoralen Reaktion auf die COVID-19-Impfung aus. Die T-Zell-vermittelte Immunantwort bleibt bei der Mehrheit erhalten, dennoch bleibt das Ausmaß des Schutzes unklar. Yusof et al. ermittelten die Inzidenz von SARS-CoV-2-Durchbruchsinfektionen und bewerteten Prädiktoren für mittelschwere bis schwere COVID-19-Ergebnisse.
{"title":"Rituximab-Therapie wirkt sich auf Immunschutz durch COVID-19-Impfung\u0000 aus","authors":"","doi":"10.1055/a-2042-7459","DOIUrl":"https://doi.org/10.1055/a-2042-7459","url":null,"abstract":"\u0000 Eine Rituximab-Therapie wirkt sich bei Patienten mit rheumatischen und\u0000 muskuloskelettalen Erkrankungen mit einer verringerten humoralen Reaktion\u0000 auf die COVID-19-Impfung aus. Die T-Zell-vermittelte Immunantwort bleibt bei\u0000 der Mehrheit erhalten, dennoch bleibt das Ausmaß des Schutzes\u0000 unklar. Yusof et al. ermittelten die Inzidenz von\u0000 SARS-CoV-2-Durchbruchsinfektionen und bewerteten Prädiktoren\u0000 für mittelschwere bis schwere COVID-19-Ergebnisse.\u0000","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49334044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bisher konnte sich keine Methodik zur Bewertung der Krankheitsaktivität bei Großgefäßvaskulitis in der klinischen Praxis als valide und nützlich erweisen. Galli et al. untersuchten die Genauigkeit der Positronen-Emissions-Tomographie in Kombination mit der Computertomographie (PET/CT) und des PET Vascular Activity Score (PETVAS) zur Beurteilung der Krankheitsaktivität und zur Vorhersage von Rückfällen.
{"title":"PET/CT zeigt nur mäßige Genauigkeit bei\u0000 Einstufung von Großgefäßvaskulitis","authors":"","doi":"10.1055/a-1992-2415","DOIUrl":"https://doi.org/10.1055/a-1992-2415","url":null,"abstract":"\u0000 Bisher konnte sich keine Methodik zur Bewertung der Krankheitsaktivität\u0000 bei Großgefäßvaskulitis in der klinischen Praxis als\u0000 valide und nützlich erweisen. Galli et al. untersuchten die\u0000 Genauigkeit der Positronen-Emissions-Tomographie in Kombination mit der\u0000 Computertomographie (PET/CT) und des PET Vascular Activity Score\u0000 (PETVAS) zur Beurteilung der Krankheitsaktivität und zur Vorhersage von\u0000 Rückfällen.\u0000","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49518908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehr als 90% der Menschen mit einer symptomatischen Gonarthrose weisen in der Magnetresonanztomografie (MRT) einen begleitenden Meniskusriss auf. Bei dieser Konstellation bieten sich prinzipiell 2 Behandlungsstrategien an: Das konservative Vorgehen mit Physiotherapie und pharmakologischem Schmerzmanagement oder die arthroskopische Menisusteilresektion. Welchen Langzeitverlauf nehmen bei diesen beiden Strategien die strukturellen Gelenkschäden?
{"title":"Gonarthrose und Meniskusriss: Operation versus\u0000 Physiotherapie","authors":"","doi":"10.1055/a-1952-2744","DOIUrl":"https://doi.org/10.1055/a-1952-2744","url":null,"abstract":"\u0000 Mehr als 90% der Menschen mit einer symptomatischen Gonarthrose weisen\u0000 in der Magnetresonanztomografie (MRT) einen begleitenden Meniskusriss auf.\u0000 Bei dieser Konstellation bieten sich prinzipiell 2 Behandlungsstrategien an:\u0000 Das konservative Vorgehen mit Physiotherapie und pharmakologischem\u0000 Schmerzmanagement oder die arthroskopische Menisusteilresektion. Welchen\u0000 Langzeitverlauf nehmen bei diesen beiden Strategien die strukturellen\u0000 Gelenkschäden?\u0000","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46239184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background This study investigated physical activity, peripheral muscle strength, exercise capacity, sleep, fatigue, anxiety and depression in patients with systemic lupus erythematosus (SLE). Material and Methods Twenty-six patients with SLE, median age 32.5 (25–43) years, and 29 healthy individuals, median age 30 (23–32) years, were included. Exercise capacity (6-minute walk test (6MWT)), peripheral muscle strength (dynamometer), physical activity (Mi Band 4 smart band), fatigue (Fatigue Severity Scale (FSS)), anxiety and depression (Hospital Anxiety Depression scale (HAD)), quality of life (SLE-specific QOL scale (SLEQoL)) and sleep (Pittsburgh Sleep Quality Index (PSQI)) were assessed. Results Demographic characteristics were similar in both groups. 6MWT distance, peripheral muscle strength, physical activity level, SLEQoL and PSQI scores were significantly lower, while FSS and HAD scores were higher in patients with SLE (p<0.05). Moreover, pre-test and post-test heart rates, dyspnea and fatigue severity scores were higher in patients with SLE than in healthy individuals (p<0.05). Conclusion Patients with SLE had lower exercise capacity, muscle strength, physical activity, quality of life and sleep quality, along with more common fatigue, anxiety and depression. Strategies need to be developed to improve these symptoms in patients with SLE for a favourable outcome.
摘要背景本研究调查了系统性红斑狼疮（SLE）患者的体力活动、外周肌力、运动能力、睡眠、疲劳、焦虑和抑郁。材料和方法纳入26名SLE患者，中位年龄32.5（25-43）岁，29名健康人，中位年纪30（23-32）岁。评估运动能力（6分钟步行测试（6MWT））、外周肌力（测功机）、体力活动（Mi Band 4智能带）、疲劳（疲劳严重程度量表（FSS））、焦虑和抑郁（医院焦虑抑郁量表（HAD））、生活质量（SLE特异性生活质量量表（SLEQoL））和睡眠（匹兹堡睡眠质量指数（PSQI））。结果两组患者的人口学特征相似。SLE患者6MWT距离、外周肌力、体力活动水平、SLEQoL和PSQI评分显著降低，FSS和HAD评分较高（p<0.05）。此外，SLE患者测试前和测试后心率、呼吸困难和疲劳严重程度评分高于健康人（p<0.05），肌肉力量、体力活动、生活质量和睡眠质量，以及更常见的疲劳、焦虑和抑郁。需要制定策略来改善SLE患者的这些症状，以获得有利的结果。
{"title":"Comparison of Exercise Capacity, Physical Activity Level and Peripheral Muscle Strength in Systemic Lupus Erythematosus Patients with Healthy Individuals","authors":"F. Sari, S. Bayram, D. Oskay, A. Tufan","doi":"10.1055/a-2106-7129","DOIUrl":"https://doi.org/10.1055/a-2106-7129","url":null,"abstract":"Abstract Background This study investigated physical activity, peripheral muscle strength, exercise capacity, sleep, fatigue, anxiety and depression in patients with systemic lupus erythematosus (SLE). Material and Methods Twenty-six patients with SLE, median age 32.5 (25–43) years, and 29 healthy individuals, median age 30 (23–32) years, were included. Exercise capacity (6-minute walk test (6MWT)), peripheral muscle strength (dynamometer), physical activity (Mi Band 4 smart band), fatigue (Fatigue Severity Scale (FSS)), anxiety and depression (Hospital Anxiety Depression scale (HAD)), quality of life (SLE-specific QOL scale (SLEQoL)) and sleep (Pittsburgh Sleep Quality Index (PSQI)) were assessed. Results Demographic characteristics were similar in both groups. 6MWT distance, peripheral muscle strength, physical activity level, SLEQoL and PSQI scores were significantly lower, while FSS and HAD scores were higher in patients with SLE (p<0.05). Moreover, pre-test and post-test heart rates, dyspnea and fatigue severity scores were higher in patients with SLE than in healthy individuals (p<0.05). Conclusion Patients with SLE had lower exercise capacity, muscle strength, physical activity, quality of life and sleep quality, along with more common fatigue, anxiety and depression. Strategies need to be developed to improve these symptoms in patients with SLE for a favourable outcome.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48499757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kulyk, Anna Novytska, Ruslana Potemka, O. Ivashkivskyi, T. Karasevska, Halyna Mostbauer, M. Dzhus
Abstract This case report describes the occurrence of symmetrical dactylitis of toes combined with chilblain-like acral lesions in a 32-year-old female patient 19 days after a mild coronavirus infection. The article addresses existing problems of managing patients after COVID-19 in daily clinical practice. Scientific evidence is pointing to a growing number of cases of articular and skin involvement associated with COVID-19. However, it remains unclear what approaches to use in the treatment of such patients.
{"title":"A Case Report of COVID-19-Related Dactylitis Combined with Chilblain-Like Acral Lesions","authors":"M. Kulyk, Anna Novytska, Ruslana Potemka, O. Ivashkivskyi, T. Karasevska, Halyna Mostbauer, M. Dzhus","doi":"10.1055/a-2044-0440","DOIUrl":"https://doi.org/10.1055/a-2044-0440","url":null,"abstract":"Abstract This case report describes the occurrence of symmetrical dactylitis of toes combined with chilblain-like acral lesions in a 32-year-old female patient 19 days after a mild coronavirus infection. The article addresses existing problems of managing patients after COVID-19 in daily clinical practice. Scientific evidence is pointing to a growing number of cases of articular and skin involvement associated with COVID-19. However, it remains unclear what approaches to use in the treatment of such patients.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48544723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zusammenfassung Die Behandlung der juvenilen idiopathischen Arthritis (JIA) hat in den vergangenen 25 Jahren dramatische Fortschritte gemacht. „Hit hard and early“ sind die Wesenszüge der medikamentösen Behandlung entzündlich-rheumatischer Erkrankungen heutzutage [7,9,11,12]. Im Zeitalter der Biologika läßt die medikamentöse Vielfalt multiple Variationen zu, um den Erkrankungsprozess zu verlangsamen oder gar zu stoppen [19]. Deshalb ist es wichtig geworden, bei fehlender Rückbildung der Prozeßaktivität im Sinne einer synovialen Schwellung an Sehnen oder Gelenken frühzeitig die Frage einer operativen Therapie zum Sehen- oder Gelenkerhalt beantwortet zu wissen [25]. Durch ein frühzeitiges Interagieren von medikamentöser und operativer Therapie kann dem betroffenen jungen Rheumatiker langfristig eine schmerzarme und wenig funktionsgeminderte Alltagstauglichkeit nicht nur der Hand geschaffen werden. Dabei hat der Sehnen- und Gelenkerhalt nicht nur an der Hand höchste Priorität vor den rekonstruktiven operativen Möglichkeiten.
{"title":"Operative Eingriffe im Bereich der Hand und des Handgelenkes bei rheumatischen Affektionen in der Jugend","authors":"M. Arbogast","doi":"10.1055/a-2041-3117","DOIUrl":"https://doi.org/10.1055/a-2041-3117","url":null,"abstract":"Zusammenfassung Die Behandlung der juvenilen idiopathischen Arthritis (JIA) hat in den vergangenen 25 Jahren dramatische Fortschritte gemacht. „Hit hard and early“ sind die Wesenszüge der medikamentösen Behandlung entzündlich-rheumatischer Erkrankungen heutzutage [7,9,11,12]. Im Zeitalter der Biologika läßt die medikamentöse Vielfalt multiple Variationen zu, um den Erkrankungsprozess zu verlangsamen oder gar zu stoppen [19]. Deshalb ist es wichtig geworden, bei fehlender Rückbildung der Prozeßaktivität im Sinne einer synovialen Schwellung an Sehnen oder Gelenken frühzeitig die Frage einer operativen Therapie zum Sehen- oder Gelenkerhalt beantwortet zu wissen [25]. Durch ein frühzeitiges Interagieren von medikamentöser und operativer Therapie kann dem betroffenen jungen Rheumatiker langfristig eine schmerzarme und wenig funktionsgeminderte Alltagstauglichkeit nicht nur der Hand geschaffen werden. Dabei hat der Sehnen- und Gelenkerhalt nicht nur an der Hand höchste Priorität vor den rekonstruktiven operativen Möglichkeiten.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"48 1","pages":"203 - 211"},"PeriodicalIF":0.2,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43685335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İ. Doğan, S. Güven, Ö. Karakaş, E. Erdoğan, Ş. Erten
Abstract Objective To evaluate the adherence to colchicine treatment during pregnancy and lactation in our Familial Mediterranean fever (FMF) patients and investigate the reasons for non-adherence and consequences. Methods Adult female FMF patients who were followed up in our rheumatology clinic and had a history of pregnancy after the diagnosis of FMF were consecutively enrolled to this cross-sectional study between November 2021 and June 2022. Only pregnancies occurring after the diagnosis of FMF were evaluated. Patients who did not stop using FMF treatment after pregnancy were considered to adhere to treatment. Results In 50 patients, a total of 88 pregnancies and 58 live births were observed after the diagnosis of FMF. 37 (74%) had at least one completed pregnancy, and 13 (26.0) were pregnant during the study. Among the 37 patients, 34 had at least one live birth. No significant differences were observed when rates of patients with a history of at least one live birth, abortus, Cesarean section (C/S), preterm labor, stillbirth, intrauterine anomaly, congenital malformation and fetal growth retardation were compared between colchicine users and non-users. 60% of the patients adhered to colchicine treatment during pregnancy and 73.4% did so while breastfeeding. The most common reason for colchicine cessation was concerns regarding potential harm to the fetus (70%), followed by the presumption that colchicine is contraindicated in pregnancy (15%) as well as absence of FMF attacks (10%). The most common source of the patients’ opinion was a physician (60%). Conclusions Both patients and attending physicians should be informed to be more adherent to colchicine to avoid adverse outcomes and FMF-related complications.
{"title":"Adherence to Colchicine During Pregnancy in Familial Mediterranean Fever Patients: Reasons for Cessation and Outcomes from a Single-Centre Experience","authors":"İ. Doğan, S. Güven, Ö. Karakaş, E. Erdoğan, Ş. Erten","doi":"10.1055/a-2021-7668","DOIUrl":"https://doi.org/10.1055/a-2021-7668","url":null,"abstract":"Abstract Objective To evaluate the adherence to colchicine treatment during pregnancy and lactation in our Familial Mediterranean fever (FMF) patients and investigate the reasons for non-adherence and consequences. Methods Adult female FMF patients who were followed up in our rheumatology clinic and had a history of pregnancy after the diagnosis of FMF were consecutively enrolled to this cross-sectional study between November 2021 and June 2022. Only pregnancies occurring after the diagnosis of FMF were evaluated. Patients who did not stop using FMF treatment after pregnancy were considered to adhere to treatment. Results In 50 patients, a total of 88 pregnancies and 58 live births were observed after the diagnosis of FMF. 37 (74%) had at least one completed pregnancy, and 13 (26.0) were pregnant during the study. Among the 37 patients, 34 had at least one live birth. No significant differences were observed when rates of patients with a history of at least one live birth, abortus, Cesarean section (C/S), preterm labor, stillbirth, intrauterine anomaly, congenital malformation and fetal growth retardation were compared between colchicine users and non-users. 60% of the patients adhered to colchicine treatment during pregnancy and 73.4% did so while breastfeeding. The most common reason for colchicine cessation was concerns regarding potential harm to the fetus (70%), followed by the presumption that colchicine is contraindicated in pregnancy (15%) as well as absence of FMF attacks (10%). The most common source of the patients’ opinion was a physician (60%). Conclusions Both patients and attending physicians should be informed to be more adherent to colchicine to avoid adverse outcomes and FMF-related complications.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41783999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gulnihal Deniz, Furkan Bilek, S. B. Yentur, G. Akgol
Abstract Aim We aimed to examine the effect of kinesiophobia on functional capacity, disease activity, quality of life and spatiotemporal parameters of patients with AS by comparing AS patients with healthy controls. Material and method Our study included 46 patients with ankylosing spondylitis (AS) and 45 healthy controls (HC). Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Quality of Life Scale (ASQoL), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Tampa Kinesiophobia Scale (TKS) scores, Timed Up and Go (TUG) test, maximum plantar pressure and spatiotemporal parameters (total weight transfer, step cycle duration, double-support phase, swing phase, step length, foot angle and cadence) were evaluated. Results Ninety-one individuals (46 AS, 45 HC) (age/sex/BMI) were included in our study. Statistically significant differences were seen between AS and HC groups in TUG, cadence, TKS, maximum pressure, step cycle duration, swing phase, step length, double-support phase, and foot angle measurements (p<0.05). Significant positive correlations existed between TKS and BASMI, BASDAI, BASFI, ASoQ, TUG and foot angle (p<0.05) in AS. Substantial negative correlations were found between TKS and maximum pressure, cadence and swing phase values (p<0.05) in AS. Conclusion Our study is the first in the literature to measure spatiotemporal parameters between patients with AS and HC and evaluate their relationship with kinesiophobia, which was done to the best of our knowledge. We found that patients with AS changed their gait phases by developing a unique pattern and created a more cautious and safe gait model to provide balance and stability. Our study revealed a statistically significant relationship between kinesiophobia and disease activity, functional status, quality of life, cadence, maximum plantar pressure, swing phase, and foot angle. The detailed data we obtained in our study will shed light on gait analysis and research on kinesiophobia in patients with AS. Kinesiophobia should be evaluated in routine gait rehabilitation protocols applied to individuals with AS, and treatment protocols for kinesiophobia should be added if necessary.
{"title":"Does Kinesiophobia Affect Spatiotemporal Parameters in Patients with Ankylosing Spondylitis?","authors":"Gulnihal Deniz, Furkan Bilek, S. B. Yentur, G. Akgol","doi":"10.1055/a-2035-9233","DOIUrl":"https://doi.org/10.1055/a-2035-9233","url":null,"abstract":"Abstract Aim We aimed to examine the effect of kinesiophobia on functional capacity, disease activity, quality of life and spatiotemporal parameters of patients with AS by comparing AS patients with healthy controls. Material and method Our study included 46 patients with ankylosing spondylitis (AS) and 45 healthy controls (HC). Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Quality of Life Scale (ASQoL), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Tampa Kinesiophobia Scale (TKS) scores, Timed Up and Go (TUG) test, maximum plantar pressure and spatiotemporal parameters (total weight transfer, step cycle duration, double-support phase, swing phase, step length, foot angle and cadence) were evaluated. Results Ninety-one individuals (46 AS, 45 HC) (age/sex/BMI) were included in our study. Statistically significant differences were seen between AS and HC groups in TUG, cadence, TKS, maximum pressure, step cycle duration, swing phase, step length, double-support phase, and foot angle measurements (p<0.05). Significant positive correlations existed between TKS and BASMI, BASDAI, BASFI, ASoQ, TUG and foot angle (p<0.05) in AS. Substantial negative correlations were found between TKS and maximum pressure, cadence and swing phase values (p<0.05) in AS. Conclusion Our study is the first in the literature to measure spatiotemporal parameters between patients with AS and HC and evaluate their relationship with kinesiophobia, which was done to the best of our knowledge. We found that patients with AS changed their gait phases by developing a unique pattern and created a more cautious and safe gait model to provide balance and stability. Our study revealed a statistically significant relationship between kinesiophobia and disease activity, functional status, quality of life, cadence, maximum plantar pressure, swing phase, and foot angle. The detailed data we obtained in our study will shed light on gait analysis and research on kinesiophobia in patients with AS. Kinesiophobia should be evaluated in routine gait rehabilitation protocols applied to individuals with AS, and treatment protocols for kinesiophobia should be added if necessary.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47882817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Systemischen Lupus erythematodes (SLE) wird durch Gene der Immunresponse-Signalwege und dem Major Histocompatibility Complex Klasse I und II beeinflusst. Iberdomid ist ein hochaffiner Cereblon-Ligand, der den proteasomalen Abbau der Transkriptionsfaktoren Ikaros (IKZF1) und Aiolos (IKZF3) fördert. P. E. Lipsky und Kollegen untersuchten nun die Pharmakodynamik und Pharmakokinetik von oral verabreichtem Iberdomid bei Patienten mit SLE.
{"title":"Systemischer Lupus erythematodes: Biologische Wirkung von\u0000 Iberdomid","authors":"","doi":"10.1055/a-1950-2783","DOIUrl":"https://doi.org/10.1055/a-1950-2783","url":null,"abstract":"\u0000 Systemischen Lupus erythematodes (SLE) wird durch Gene der\u0000 Immunresponse-Signalwege und dem Major Histocompatibility Complex Klasse I und\u0000 II beeinflusst. Iberdomid ist ein hochaffiner Cereblon-Ligand, der den\u0000 proteasomalen Abbau der Transkriptionsfaktoren Ikaros (IKZF1) und Aiolos (IKZF3)\u0000 fördert. P. E. Lipsky und Kollegen untersuchten nun die Pharmakodynamik\u0000 und Pharmakokinetik von oral verabreichtem Iberdomid bei Patienten mit SLE.\u0000","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48368412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Die aktuell gültigen Leitlinien zur Therapie der Lupusnephritis empfehlen zur Remissionsinduktion initial Prednisondosen zwischen 0,3 und 1,0mg/kg pro Tag. Angesichts der damit verbundenen Nebenwirkungen ging ein kanadisches Forscherteam der Frage nach, ob niedrigere Dosen zu ähnlich guten Ergebnissen führen.
{"title":"Lupusnephritis: Hohe versus mittlere Prednison-Initialdosis","authors":"","doi":"10.1055/a-1952-2640","DOIUrl":"https://doi.org/10.1055/a-1952-2640","url":null,"abstract":"\u0000 Die aktuell gültigen Leitlinien zur Therapie der Lupusnephritis empfehlen zur Remissionsinduktion initial Prednisondosen zwischen 0,3 und 1,0mg/kg pro Tag. Angesichts der damit verbundenen Nebenwirkungen ging ein kanadisches Forscherteam der Frage nach, ob niedrigere Dosen zu ähnlich guten Ergebnissen führen.\u0000","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46093300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：